                               SEQUENCE LISTING

<110> BIOMARIN TECHNOLOGIES B.V.
 
<120> OLIGONUCLEOTIDE

<130> 0105 26 WO

<140>
<141>

<150> 63/085,668
<151> 2020-09-30

<160> 22490 

<170> PatentIn version 3.5

<210> 1
<211> 3685
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="dystrophin"

<400> 1
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 


Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     


Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         


Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             


Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 


Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 


Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     


Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         


Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             


Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 


Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 


Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     


Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         


Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             


Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 


Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 


Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     


Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         


Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             


Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             


Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             


His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             


Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             


Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             


Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             


Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             


Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             


Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             


Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             


Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             


Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             


Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             


Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             


Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             


Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             


Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             


Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             


Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             


Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             


Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             


Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             


Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             


Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             


Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             


Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             


Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             


Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             


Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             


Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             


Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Gln Arg  Leu Gln Glu 
    1460                 1465                 1470             


Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             


Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             


His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             


Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             


Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             


Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             


Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             


Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             


Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             


Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             


Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             


Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             


Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             


Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             


Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             


Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             


Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             


Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             


Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             


Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             


Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             


Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             


Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             


Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             


Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             


Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             


Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             


Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             


Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             


Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             


Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             


Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             


Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             


Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             


Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             


Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             


Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             


Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             


Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             


Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             


Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             


Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             


Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             


Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             


Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             


Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             


Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             


Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             


Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             


Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             


Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             


Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             


Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             


Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             


Gln Glu  Gly Pro Phe Asp Val  Gln Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             


Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             


Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             


Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             


Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             


Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             


Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             


Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             


Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             


Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             


Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             


Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             


Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             


Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             


Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             


Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             


Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             


Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             


Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             


Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             


Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             


His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             


Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             


Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             


Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             


Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             


Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             


Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             


Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             


Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             


Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             


Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             


Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             


Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             


Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             


Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             


Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             


Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             


Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             


Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             


Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             


His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             


Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             


Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             


Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             


Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             


Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             


Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             


Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             


Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             


Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             


His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             


Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             


His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             


Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             


Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             


Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             


Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             


Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             


Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             


Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             


Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             


Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             


Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             


Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             


Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             


Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             


Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210> 2
<211> 233
<212> RNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Exon 51"

<400> 2
cuccuacuca gacuguuacu cuggugacac aaccuguggu uacuaaggaa acugccaucu       60

ccaaacuaga aaugccaucu uccuugaugu uggagguacc ugcucuggca gauuucaacc      120

gggcuuggac agaacuuacc gacuggcuuu cucugcuuga ucaaguuaua aaaucacaga      180

gggugauggu gggugaccuu gaggauauca acgagaugau caucaagcag aag             233


<210> 3
<211> 11
<212> RNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Exon Splicing Enhancer 1"

<400> 3
ggacagaacu u                                                            11


<210> 4
<211> 11
<212> RNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Exon Splicing Enhancer 1 (reverse complement)"

<400> 4
aaguucuguc c                                                            11


<210> 5
<211> 6
<212> RNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Exon Splicing Enhancer 2"

<400> 5
aucuuc                                                                   6


<210> 6
<211> 6
<212> RNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Exon Splicing Enhancer 2 (reverse complement)"

<400> 6
gaagau                                                                   6


<210> 7
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Drisapersen/Suvodirsen"

<400> 7
ucaaggaaga uggcauuucu                                                   20


<210> 8
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Eteplirsen"

<400> 8
ctccaacatc aaggaagatg gcatttctag                                        30


<210> 9
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 9
ucaaggaaga uggcauuucu                                                   20


<210> 10
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 10
ucaaggaaga uggcauuucu ag                                                22


<210> 11
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 11
gguaaguucu guccaagc                                                     18


<210> 12
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 12
guaaguucug uccaagcc                                                     18


<210> 13
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 13
agucgguaag uucugucc                                                     18


<210> 14
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 14
cuguccaagc ccgguuga                                                     18


<210> 15
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 15
uaaguucugu ccaag                                                        15


<210> 16
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 16
uucuguccaa gcccgguuga                                                   20


<210> 17
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 17
uucuguccaa gcccgguug                                                    19


<210> 18
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 18
uucuguccaa gcccgguu                                                     18


<210> 19
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 19
uucuguccaa gcccggu                                                      17


<210> 20
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 20
uucuguccaa gcccgg                                                       16


<210> 21
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 21
uucuguccaa gcccg                                                        15


<210> 22
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 22
uucuguccaa gccc                                                         14


<210> 23
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 23
uucuguccaa gcc                                                          13


<210> 24
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 24
uucuguccaa gc                                                           12


<210> 25
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 25
uucuguccaa g                                                            11


<210> 26
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 26
uucuguccaa                                                              10


<210> 27
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 27
uucugucca                                                                9


<210> 28
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 28
uucugucc                                                                 8


<210> 29
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 29
ucuguccaag cccgguuga                                                    19


<210> 30
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 30
ucuguccaag cccgguug                                                     18


<210> 31
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 31
ucuguccaag cccgguu                                                      17


<210> 32
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 32
ucuguccaag cccggu                                                       16


<210> 33
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 33
ucuguccaag cccgg                                                        15


<210> 34
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 34
ucuguccaag cccg                                                         14


<210> 35
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 35
ucuguccaag ccc                                                          13


<210> 36
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 36
ucuguccaag cc                                                           12


<210> 37
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 37
ucuguccaag c                                                            11


<210> 38
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 38
ucuguccaag                                                              10


<210> 39
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 39
ucuguccaa                                                                9


<210> 40
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 40
ucugucca                                                                 8


<210> 41
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 41
cuguccaagc ccgguug                                                      17


<210> 42
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 42
cuguccaagc ccgguu                                                       16


<210> 43
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 43
cuguccaagc ccggu                                                        15


<210> 44
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 44
cuguccaagc ccgg                                                         14


<210> 45
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 45
cuguccaagc ccg                                                          13


<210> 46
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 46
cuguccaagc cc                                                           12


<210> 47
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 47
cuguccaagc c                                                            11


<210> 48
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 48
cuguccaagc                                                              10


<210> 49
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 49
cuguccaag                                                                9


<210> 50
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 50
cuguccaa                                                                 8


<210> 51
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 51
guucugucca agcccgguug                                                   20


<210> 52
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 52
guucugucca agcccgguu                                                    19


<210> 53
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 53
guucugucca agcccggu                                                     18


<210> 54
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 54
guucugucca agcccgg                                                      17


<210> 55
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 55
guucugucca agcccg                                                       16


<210> 56
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 56
guucugucca agccc                                                        15


<210> 57
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 57
guucugucca agcc                                                         14


<210> 58
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 58
guucugucca agc                                                          13


<210> 59
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 59
guucugucca ag                                                           12


<210> 60
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 60
guucugucca a                                                            11


<210> 61
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 61
guucugucca                                                              10


<210> 62
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 62
guucugucc                                                                9


<210> 63
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 63
guucuguc                                                                 8


<210> 64
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 64
aguucugucc aagcccgguu                                                   20


<210> 65
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 65
aguucugucc aagcccggu                                                    19


<210> 66
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 66
aguucugucc aagcccgg                                                     18


<210> 67
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 67
aguucugucc aagcccg                                                      17


<210> 68
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 68
aguucugucc aagccc                                                       16


<210> 69
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 69
aguucugucc aagcc                                                        15


<210> 70
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 70
aguucugucc aagc                                                         14


<210> 71
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 71
aguucugucc aag                                                          13


<210> 72
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 72
aguucugucc aa                                                           12


<210> 73
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 73
aguucugucc a                                                            11


<210> 74
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 74
aguucugucc                                                              10


<210> 75
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 75
aguucuguc                                                                9


<210> 76
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 76
aguucugu                                                                 8


<210> 77
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 77
aaguucuguc caagcccggu                                                   20


<210> 78
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 78
aaguucuguc caagcccgg                                                    19


<210> 79
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 79
aaguucuguc caagcccg                                                     18


<210> 80
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 80
aaguucuguc caagccc                                                      17


<210> 81
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 81
aaguucuguc caagcc                                                       16


<210> 82
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 82
aaguucuguc caagc                                                        15


<210> 83
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 83
aaguucuguc caag                                                         14


<210> 84
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 84
aaguucuguc caa                                                          13


<210> 85
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 85
aaguucuguc ca                                                           12


<210> 86
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 86
aaguucuguc c                                                            11


<210> 87
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 87
aaguucuguc                                                              10


<210> 88
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 88
aaguucugu                                                                9


<210> 89
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 89
aaguucug                                                                 8


<210> 90
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 90
uaaguucugu ccaagcccgg                                                   20


<210> 91
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 91
uaaguucugu ccaagcccg                                                    19


<210> 92
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 92
uaaguucugu ccaagccc                                                     18


<210> 93
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 93
uaaguucugu ccaagcc                                                      17


<210> 94
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 94
uaaguucugu ccaagc                                                       16


<210> 95
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 95
uaaguucugu ccaa                                                         14


<210> 96
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 96
uaaguucugu cca                                                          13


<210> 97
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 97
uaaguucugu cc                                                           12


<210> 98
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 98
uaaguucugu c                                                            11


<210> 99
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 99
uaaguucugu                                                              10


<210> 100
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 100
uaaguucug                                                                9


<210> 101
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 101
uaaguucu                                                                 8


<210> 102
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 102
guaaguucug uccaagcccg                                                   20


<210> 103
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 103
guaaguucug uccaagccc                                                    19


<210> 104
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 104
guaaguucug uccaagc                                                      17


<210> 105
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 105
guaaguucug uccaag                                                       16


<210> 106
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 106
guaaguucug uccaa                                                        15


<210> 107
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 107
guaaguucug ucca                                                         14


<210> 108
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 108
guaaguucug ucc                                                          13


<210> 109
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 109
guaaguucug uc                                                           12


<210> 110
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 110
guaaguucug u                                                            11


<210> 111
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 111
guaaguucug                                                              10


<210> 112
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 112
guaaguucu                                                                9


<210> 113
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 113
guaaguuc                                                                 8


<210> 114
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 114
gguaaguucu guccaagccc                                                   20


<210> 115
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 115
gguaaguucu guccaagcc                                                    19


<210> 116
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 116
gguaaguucu guccaag                                                      17


<210> 117
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 117
gguaaguucu guccaa                                                       16


<210> 118
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 118
gguaaguucu gucca                                                        15


<210> 119
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 119
gguaaguucu gucc                                                         14


<210> 120
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 120
gguaaguucu guc                                                          13


<210> 121
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 121
gguaaguucu gu                                                           12


<210> 122
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 122
gguaaguucu g                                                            11


<210> 123
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 123
gguaaguucu                                                              10


<210> 124
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 124
gguaaguuc                                                                9


<210> 125
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 125
gguaaguu                                                                 8


<210> 126
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 126
cgguaaguuc uguccaagcc                                                   20


<210> 127
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 127
cgguaaguuc uguccaagc                                                    19


<210> 128
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 128
cgguaaguuc uguccaag                                                     18


<210> 129
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 129
cgguaaguuc uguccaa                                                      17


<210> 130
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 130
cgguaaguuc ugucca                                                       16


<210> 131
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 131
cgguaaguuc ugucc                                                        15


<210> 132
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 132
cgguaaguuc uguc                                                         14


<210> 133
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 133
cgguaaguuc ugu                                                          13


<210> 134
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 134
cgguaaguuc ug                                                           12


<210> 135
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 135
cgguaaguuc u                                                            11


<210> 136
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 136
cgguaaguuc                                                              10


<210> 137
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 137
cgguaaguu                                                                9


<210> 138
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 138
cgguaagu                                                                 8


<210> 139
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 139
ucgguaaguu cuguccaagc                                                   20


<210> 140
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 140
ucgguaaguu cuguccaag                                                    19


<210> 141
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 141
ucgguaaguu cuguccaa                                                     18


<210> 142
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 142
ucgguaaguu cugucca                                                      17


<210> 143
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 143
ucgguaaguu cugucc                                                       16


<210> 144
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 144
ucgguaaguu cuguc                                                        15


<210> 145
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 145
ucgguaaguu cugu                                                         14


<210> 146
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 146
ucgguaaguu cug                                                          13


<210> 147
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 147
ucgguaaguu cu                                                           12


<210> 148
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 148
ucgguaaguu c                                                            11


<210> 149
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 149
ucgguaaguu                                                              10


<210> 150
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 150
ucgguaagu                                                                9


<210> 151
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 151
gucgguaagu ucuguccaag                                                   20


<210> 152
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 152
gucgguaagu ucuguccaa                                                    19


<210> 153
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 153
gucgguaagu ucugucca                                                     18


<210> 154
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 154
gucgguaagu ucugucc                                                      17


<210> 155
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 155
gucgguaagu ucuguc                                                       16


<210> 156
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 156
gucgguaagu ucugu                                                        15


<210> 157
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 157
gucgguaagu ucug                                                         14


<210> 158
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 158
gucgguaagu ucu                                                          13


<210> 159
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 159
gucgguaagu uc                                                           12


<210> 160
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 160
gucgguaagu u                                                            11


<210> 161
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 161
gucgguaagu                                                              10


<210> 162
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 162
agucgguaag uucuguccaa                                                   20


<210> 163
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 163
agucgguaag uucugucca                                                    19


<210> 164
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 164
agucgguaag uucuguc                                                      17


<210> 165
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 165
agucgguaag uucugu                                                       16


<210> 166
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 166
agucgguaag uucug                                                        15


<210> 167
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 167
agucgguaag uucu                                                         14


<210> 168
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 168
agucgguaag uuc                                                          13


<210> 169
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 169
agucgguaag uu                                                           12


<210> 170
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 170
agucgguaag u                                                            11


<210> 171
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 171
cagucgguaa guucugucca                                                   20


<210> 172
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 172
cagucgguaa guucugucc                                                    19


<210> 173
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 173
cagucgguaa guucuguc                                                     18


<210> 174
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 174
cagucgguaa guucugu                                                      17


<210> 175
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 175
cagucgguaa guucug                                                       16


<210> 176
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 176
cagucgguaa guucu                                                        15


<210> 177
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 177
cagucgguaa guuc                                                         14


<210> 178
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 178
cagucgguaa guu                                                          13


<210> 179
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 179
cagucgguaa gu                                                           12


<210> 180
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 180
ccagucggua aguucugucc                                                   20


<210> 181
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 181
ccagucggua aguucuguc                                                    19


<210> 182
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 182
ccagucggua aguucugu                                                     18


<210> 183
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 183
ccagucggua aguucug                                                      17


<210> 184
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 184
ccagucggua aguucu                                                       16


<210> 185
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 185
ccagucggua aguuc                                                        15


<210> 186
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 186
ccagucggua aguu                                                         14


<210> 187
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 187
ccagucggua agu                                                          13


<210> 188
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 188
gccagucggu aaguucuguc                                                   20


<210> 189
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 189
gccagucggu aaguucugu                                                    19


<210> 190
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 190
gccagucggu aaguucug                                                     18


<210> 191
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 191
gccagucggu aaguucu                                                      17


<210> 192
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 192
gccagucggu aaguuc                                                       16


<210> 193
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 193
gccagucggu aaguu                                                        15


<210> 194
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 194
gccagucggu aagu                                                         14


<210> 195
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 195
ucaaggaaga uggcauuucu                                                   20


<210> 196
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 196
ucaaggaaga uggcauuucu ag                                                22


<210> 197
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 197
ucaaggaaga uggcau                                                       16


<210> 198
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 198
gaagauggca uuucu                                                        15


<210> 199
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 199
ucaaggaaga uggcauuucu a                                                 21


<210> 200
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 200
ucaaggaaga uggcauuuc                                                    19


<210> 201
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 201
ucaaggaaga uggcauuu                                                     18


<210> 202
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 202
ucaaggaaga uggcauu                                                      17


<210> 203
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 203
ucaaggaaga uggca                                                        15


<210> 204
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 204
ucaaggaaga uggc                                                         14


<210> 205
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 205
ucaaggaaga ugg                                                          13


<210> 206
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 206
ucaaggaaga ug                                                           12


<210> 207
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 207
ucaaggaaga u                                                            11


<210> 208
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 208
ucaaggaaga                                                              10


<210> 209
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 209
ucaaggaag                                                                9


<210> 210
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 210
caaggaagau ggcauuucua g                                                 21


<210> 211
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 211
caaggaagau ggcauuucua                                                   20


<210> 212
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 212
caaggaagau ggcauuucu                                                    19


<210> 213
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 213
caaggaagau ggcauuuc                                                     18


<210> 214
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 214
caaggaagau ggcauuu                                                      17


<210> 215
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 215
caaggaagau ggcauu                                                       16


<210> 216
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 216
caaggaagau ggcau                                                        15


<210> 217
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 217
caaggaagau ggca                                                         14


<210> 218
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 218
caaggaagau ggc                                                          13


<210> 219
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 219
caaggaagau gg                                                           12


<210> 220
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 220
caaggaagau g                                                            11


<210> 221
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 221
caaggaagau                                                              10


<210> 222
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"

<400> 222
caaggaaga                                                                9


<210> 223
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"

<400> 223
caaggaag                                                                 8


<210> 224
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 224
aaggaagaug gcauuucuag                                                   20


<210> 225
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 225
aaggaagaug gcauuucua                                                    19


<210> 226
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 226
aaggaagaug gcauuucu                                                     18


<210> 227
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 227
aaggaagaug gcauuuc                                                      17


<210> 228
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 228
aaggaagaug gcauuu                                                       16


<210> 229
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 229
aaggaagaug gcauu                                                        15


<210> 230
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 230
aaggaagaug gcau                                                         14


<210> 231
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 231
aaggaagaug gca                                                          13


<210> 232
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 232
aaggaagaug gc                                                           12


<210> 233
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 233
aaggaagaug g                                                            11


<210> 234
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 234
aaggaagaug                                                              10


<210> 235
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 235
aaggaagau                                                                9


<210> 236
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"

<400> 236
aaggaaga                                                                 8


<210> 237
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 237
aggaagaugg cauuucuag                                                    19


<210> 238
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 238
aggaagaugg cauuucua                                                     18


<210> 239
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 239
aggaagaugg cauuucu                                                      17


<210> 240
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 240
aggaagaugg cauuuc                                                       16


<210> 241
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 241
aggaagaugg cauuu                                                        15


<210> 242
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 242
aggaagaugg cauu                                                         14


<210> 243
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 243
aggaagaugg cau                                                          13


<210> 244
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 244
aggaagaugg ca                                                           12


<210> 245
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 245
aggaagaugg                                                              10


<210> 246
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 246
aggaagaug                                                                9


<210> 247
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 247
aggaagau                                                                 8


<210> 248
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 248
ggaagauggc auuucuag                                                     18


<210> 249
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 249
ggaagauggc auuucua                                                      17


<210> 250
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 250
ggaagauggc auuucu                                                       16


<210> 251
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 251
ggaagauggc auuuc                                                        15


<210> 252
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 252
ggaagauggc auuu                                                         14


<210> 253
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 253
ggaagauggc auu                                                          13


<210> 254
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 254
ggaagauggc au                                                           12


<210> 255
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 255
ggaagauggc a                                                            11


<210> 256
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 256
ggaagauggc                                                              10


<210> 257
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 257
ggaagaug                                                                 8


<210> 258
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 258
gaagauggca uuucuag                                                      17


<210> 259
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 259
gaagauggca uuucua                                                       16


<210> 260
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 260
gaagauggca uuuc                                                         14


<210> 261
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 261
gaagauggca uuu                                                          13


<210> 262
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 262
gaagauggca uu                                                           12


<210> 263
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 263
gaagauggca u                                                            11


<210> 264
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 264
gaagauggca                                                              10


<210> 265
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 265
gaagauggc                                                                9


<210> 266
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 266
gaagaugg                                                                 8


<210> 267
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 267
aagauggcau uucuag                                                       16


<210> 268
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 268
aagauggcau uucua                                                        15


<210> 269
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 269
aagauggcau uucu                                                         14


<210> 270
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 270
aagauggcau uuc                                                          13


<210> 271
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 271
aagauggcau uu                                                           12


<210> 272
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 272
aagauggcau u                                                            11


<210> 273
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 273
aagauggcau                                                              10


<210> 274
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 274
aagauggca                                                                9


<210> 275
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 275
aagauggc                                                                 8


<210> 276
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 276
agauggcauu ucuag                                                        15


<210> 277
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 277
agauggcauu ucua                                                         14


<210> 278
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 278
agauggcauu ucu                                                          13


<210> 279
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 279
agauggcauu uc                                                           12


<210> 280
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 280
agauggcauu u                                                            11


<210> 281
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 281
agauggcauu                                                              10


<210> 282
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 282
agauggcau                                                                9


<210> 283
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 283
agauggca                                                                 8


<210> 284
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 284
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 285
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 285
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 286
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 286
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 287
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 287
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 288
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 288
cuccaacauc aaggaagaug gcauuu                                            26


<210> 289
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 289
cuccaacauc aaggaagaug gcauu                                             25


<210> 290
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 290
cuccaacauc aaggaagaug gcau                                              24


<210> 291
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 291
cuccaacauc aaggaagaug gca                                               23


<210> 292
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 292
cuccaacauc aaggaagaug gc                                                22


<210> 293
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 293
cuccaacauc aaggaagaug g                                                 21


<210> 294
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 294
cuccaacauc aaggaagaug                                                   20


<210> 295
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 295
cuccaacauc aaggaagau                                                    19


<210> 296
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 296
cuccaacauc aaggaaga                                                     18


<210> 297
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 297
cuccaacauc aaggaag                                                      17


<210> 298
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 298
uccaacauca aggaagaugg cauuucuag                                         29


<210> 299
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 299
uccaacauca aggaagaugg cauuucua                                          28


<210> 300
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 300
uccaacauca aggaagaugg cauuucu                                           27


<210> 301
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 301
uccaacauca aggaagaugg cauuuc                                            26


<210> 302
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 302
uccaacauca aggaagaugg cauuu                                             25


<210> 303
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 303
uccaacauca aggaagaugg cauu                                              24


<210> 304
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 304
uccaacauca aggaagaugg cau                                               23


<210> 305
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 305
uccaacauca aggaagaugg ca                                                22


<210> 306
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 306
uccaacauca aggaagaugg c                                                 21


<210> 307
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 307
uccaacauca aggaagaugg                                                   20


<210> 308
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 308
uccaacauca aggaagaug                                                    19


<210> 309
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 309
uccaacauca aggaagau                                                     18


<210> 310
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 310
uccaacauca aggaaga                                                      17


<210> 311
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 311
uccaacauca aggaag                                                       16


<210> 312
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 312
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 313
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 313
ccaacaucaa ggaagauggc auuucua                                           27


<210> 314
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 314
ccaacaucaa ggaagauggc auuucu                                            26


<210> 315
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 315
ccaacaucaa ggaagauggc auuuc                                             25


<210> 316
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 316
ccaacaucaa ggaagauggc auuu                                              24


<210> 317
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 317
ccaacaucaa ggaagauggc auu                                               23


<210> 318
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 318
ccaacaucaa ggaagauggc au                                                22


<210> 319
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 319
ccaacaucaa ggaagauggc a                                                 21


<210> 320
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 320
ccaacaucaa ggaagauggc                                                   20


<210> 321
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 321
ccaacaucaa ggaagaugg                                                    19


<210> 322
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 322
ccaacaucaa ggaagaug                                                     18


<210> 323
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 323
ccaacaucaa ggaagau                                                      17


<210> 324
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 324
ccaacaucaa ggaaga                                                       16


<210> 325
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 325
ccaacaucaa ggaag                                                        15


<210> 326
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 326
caacaucaag gaagauggca uuucuag                                           27


<210> 327
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 327
caacaucaag gaagauggca uuucua                                            26


<210> 328
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 328
caacaucaag gaagauggca uuucu                                             25


<210> 329
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 329
caacaucaag gaagauggca uuuc                                              24


<210> 330
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 330
caacaucaag gaagauggca uuu                                               23


<210> 331
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 331
caacaucaag gaagauggca uu                                                22


<210> 332
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 332
caacaucaag gaagauggca u                                                 21


<210> 333
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 333
caacaucaag gaagauggca                                                   20


<210> 334
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 334
caacaucaag gaagauggc                                                    19


<210> 335
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 335
caacaucaag gaagaugg                                                     18


<210> 336
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 336
caacaucaag gaagaug                                                      17


<210> 337
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 337
caacaucaag gaagau                                                       16


<210> 338
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 338
caacaucaag gaaga                                                        15


<210> 339
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 339
caacaucaag gaag                                                         14


<210> 340
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 340
aacaucaagg aagauggcau uucuag                                            26


<210> 341
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 341
aacaucaagg aagauggcau uucua                                             25


<210> 342
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 342
aacaucaagg aagauggcau uucu                                              24


<210> 343
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 343
aacaucaagg aagauggcau uuc                                               23


<210> 344
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 344
aacaucaagg aagauggcau uu                                                22


<210> 345
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 345
aacaucaagg aagauggcau u                                                 21


<210> 346
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 346
aacaucaagg aagauggcau                                                   20


<210> 347
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 347
aacaucaagg aagauggca                                                    19


<210> 348
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 348
aacaucaagg aagauggc                                                     18


<210> 349
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 349
aacaucaagg aagaugg                                                      17


<210> 350
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 350
aacaucaagg aagaug                                                       16


<210> 351
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 351
aacaucaagg aagau                                                        15


<210> 352
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 352
aacaucaagg aaga                                                         14


<210> 353
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 353
aacaucaagg aag                                                          13


<210> 354
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 354
acaucaagga agauggcauu ucuag                                             25


<210> 355
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 355
acaucaagga agauggcauu ucua                                              24


<210> 356
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 356
acaucaagga agauggcauu ucu                                               23


<210> 357
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 357
acaucaagga agauggcauu uc                                                22


<210> 358
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 358
acaucaagga agauggcauu u                                                 21


<210> 359
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 359
acaucaagga agauggcauu                                                   20


<210> 360
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 360
acaucaagga agauggcau                                                    19


<210> 361
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 361
acaucaagga agauggca                                                     18


<210> 362
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 362
acaucaagga agauggc                                                      17


<210> 363
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 363
acaucaagga agaugg                                                       16


<210> 364
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 364
acaucaagga agaug                                                        15


<210> 365
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 365
acaucaagga agau                                                         14


<210> 366
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 366
acaucaagga aga                                                          13


<210> 367
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 367
acaucaagga ag                                                           12


<210> 368
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 368
caucaaggaa gauggcauuu cuag                                              24


<210> 369
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 369
caucaaggaa gauggcauuu cua                                               23


<210> 370
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 370
caucaaggaa gauggcauuu cu                                                22


<210> 371
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 371
caucaaggaa gauggcauuu c                                                 21


<210> 372
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 372
caucaaggaa gauggcauuu                                                   20


<210> 373
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 373
caucaaggaa gauggcauu                                                    19


<210> 374
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 374
caucaaggaa gauggcau                                                     18


<210> 375
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 375
caucaaggaa gauggca                                                      17


<210> 376
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 376
caucaaggaa gauggc                                                       16


<210> 377
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 377
caucaaggaa gaugg                                                        15


<210> 378
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 378
caucaaggaa gaug                                                         14


<210> 379
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 379
caucaaggaa gau                                                          13


<210> 380
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 380
caucaaggaa ga                                                           12


<210> 381
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 381
caucaaggaa g                                                            11


<210> 382
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 382
aucaaggaag auggcauuuc uag                                               23


<210> 383
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 383
aucaaggaag auggcauuuc ua                                                22


<210> 384
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 384
aucaaggaag auggcauuuc u                                                 21


<210> 385
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 385
aucaaggaag auggcauuuc                                                   20


<210> 386
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 386
aucaaggaag auggcauuu                                                    19


<210> 387
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 387
aucaaggaag auggcauu                                                     18


<210> 388
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 388
aucaaggaag auggcau                                                      17


<210> 389
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 389
aucaaggaag auggca                                                       16


<210> 390
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 390
aucaaggaag auggc                                                        15


<210> 391
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 391
aucaaggaag augg                                                         14


<210> 392
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 392
aucaaggaag aug                                                          13


<210> 393
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 393
aucaaggaag au                                                           12


<210> 394
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 394
aucaaggaag a                                                            11


<210> 395
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 395
aucaaggaag                                                              10


<210> 396
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 396
ccagagcagg uaccuccaac auc                                               23


<210> 397
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 397
ccagagcagg uaccucca                                                     18


<210> 398
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 398
ccucugugau uuuauaacuu gau                                               23


<210> 399
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 399
ucacccacca ucacccu                                                      17


<210> 400
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 400
ugauauccuc aaggucaccc                                                   20


<210> 401
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 401
cugcuugaug aucaucucgu ug                                                22


<210> 402
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 402
cugcuugaug aucaucuc                                                     18


<210> 403
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 403
guuuccuuag uaaccacag                                                    19


<210> 404
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<400> 404
guuuccuuag uaaccac                                                      17


<210> 405
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 405
ucaaggaaga uggcauuucu                                                   20


<210> 406
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 406
ucaaggaaga uggcauuucu ag                                                22


<210> 407
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 407
gguaaguucu guccaagc                                                     18


<210> 408
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 408
guaaguucug uccaagcc                                                     18


<210> 409
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 409
agucgguaag uucugucc                                                     18


<210> 410
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 410
cuguccaagc ccgguuga                                                     18


<210> 411
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 411
uaaguucugu ccaag                                                        15


<210> 412
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 412
uucuguccaa gcccgguuga                                                   20


<210> 413
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 413
uucuguccaa gcccgguug                                                    19


<210> 414
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 414
uucuguccaa gcccgguu                                                     18


<210> 415
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 415
uucuguccaa gcccggu                                                      17


<210> 416
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 416
uucuguccaa gcccgg                                                       16


<210> 417
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 417
uucuguccaa gcccg                                                        15


<210> 418
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 418
uucuguccaa gccc                                                         14


<210> 419
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 419
uucuguccaa gcc                                                          13


<210> 420
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 420
uucuguccaa gc                                                           12


<210> 421
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 421
uucuguccaa g                                                            11


<210> 422
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 422
uucuguccaa                                                              10


<210> 423
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 423
uucugucca                                                                9


<210> 424
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 424
uucugucc                                                                 8


<210> 425
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 425
ucuguccaag cccgguuga                                                    19


<210> 426
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 426
ucuguccaag cccgguug                                                     18


<210> 427
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 427
ucuguccaag cccgguu                                                      17


<210> 428
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 428
ucuguccaag cccggu                                                       16


<210> 429
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 429
ucuguccaag cccgg                                                        15


<210> 430
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 430
ucuguccaag cccg                                                         14


<210> 431
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 431
ucuguccaag ccc                                                          13


<210> 432
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 432
ucuguccaag cc                                                           12


<210> 433
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 433
ucuguccaag c                                                            11


<210> 434
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 434
ucuguccaag                                                              10


<210> 435
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 435
ucuguccaa                                                                9


<210> 436
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 436
ucugucca                                                                 8


<210> 437
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 437
cuguccaagc ccgguug                                                      17


<210> 438
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 438
cuguccaagc ccgguu                                                       16


<210> 439
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 439
cuguccaagc ccggu                                                        15


<210> 440
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 440
cuguccaagc ccgg                                                         14


<210> 441
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 441
cuguccaagc ccg                                                          13


<210> 442
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 442
cuguccaagc cc                                                           12


<210> 443
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 443
cuguccaagc c                                                            11


<210> 444
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 444
cuguccaagc                                                              10


<210> 445
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 445
cuguccaag                                                                9


<210> 446
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 446
cuguccaa                                                                 8


<210> 447
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 447
guucugucca agcccgguug                                                   20


<210> 448
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 448
guucugucca agcccgguu                                                    19


<210> 449
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 449
guucugucca agcccggu                                                     18


<210> 450
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 450
guucugucca agcccgg                                                      17


<210> 451
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 451
guucugucca agcccg                                                       16


<210> 452
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 452
guucugucca agccc                                                        15


<210> 453
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 453
guucugucca agcc                                                         14


<210> 454
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 454
guucugucca agc                                                          13


<210> 455
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 455
guucugucca ag                                                           12


<210> 456
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 456
guucugucca a                                                            11


<210> 457
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 457
guucugucca                                                              10


<210> 458
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 458
guucugucc                                                                9


<210> 459
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 459
guucuguc                                                                 8


<210> 460
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 460
aguucugucc aagcccgguu                                                   20


<210> 461
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 461
aguucugucc aagcccggu                                                    19


<210> 462
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 462
aguucugucc aagcccgg                                                     18


<210> 463
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 463
aguucugucc aagcccg                                                      17


<210> 464
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 464
aguucugucc aagccc                                                       16


<210> 465
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 465
aguucugucc aagcc                                                        15


<210> 466
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 466
aguucugucc aagc                                                         14


<210> 467
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 467
aguucugucc aag                                                          13


<210> 468
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 468
aguucugucc aa                                                           12


<210> 469
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 469
aguucugucc a                                                            11


<210> 470
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 470
aguucugucc                                                              10


<210> 471
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 471
aguucuguc                                                                9


<210> 472
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 472
aguucugu                                                                 8


<210> 473
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 473
aaguucuguc caagcccggu                                                   20


<210> 474
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 474
aaguucuguc caagcccgg                                                    19


<210> 475
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 475
aaguucuguc caagcccg                                                     18


<210> 476
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 476
aaguucuguc caagccc                                                      17


<210> 477
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 477
aaguucuguc caagcc                                                       16


<210> 478
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 478
aaguucuguc caagc                                                        15


<210> 479
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 479
aaguucuguc caag                                                         14


<210> 480
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 480
aaguucuguc caa                                                          13


<210> 481
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 481
aaguucuguc ca                                                           12


<210> 482
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 482
aaguucuguc c                                                            11


<210> 483
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 483
aaguucuguc                                                              10


<210> 484
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 484
aaguucugu                                                                9


<210> 485
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 485
aaguucug                                                                 8


<210> 486
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 486
uaaguucugu ccaagcccgg                                                   20


<210> 487
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 487
uaaguucugu ccaagcccg                                                    19


<210> 488
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 488
uaaguucugu ccaagccc                                                     18


<210> 489
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 489
uaaguucugu ccaagcc                                                      17


<210> 490
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 490
uaaguucugu ccaagc                                                       16


<210> 491
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 491
uaaguucugu ccaa                                                         14


<210> 492
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 492
uaaguucugu cca                                                          13


<210> 493
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 493
uaaguucugu cc                                                           12


<210> 494
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 494
uaaguucugu c                                                            11


<210> 495
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 495
uaaguucugu                                                              10


<210> 496
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 496
uaaguucug                                                                9


<210> 497
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 497
uaaguucu                                                                 8


<210> 498
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 498
guaaguucug uccaagcccg                                                   20


<210> 499
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 499
guaaguucug uccaagccc                                                    19


<210> 500
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 500
guaaguucug uccaagc                                                      17


<210> 501
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 501
guaaguucug uccaag                                                       16


<210> 502
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 502
guaaguucug uccaa                                                        15


<210> 503
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 503
guaaguucug ucca                                                         14


<210> 504
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 504
guaaguucug ucc                                                          13


<210> 505
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 505
guaaguucug uc                                                           12


<210> 506
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 506
guaaguucug u                                                            11


<210> 507
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 507
guaaguucug                                                              10


<210> 508
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 508
guaaguucu                                                                9


<210> 509
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 509
guaaguuc                                                                 8


<210> 510
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 510
gguaaguucu guccaagccc                                                   20


<210> 511
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 511
gguaaguucu guccaagcc                                                    19


<210> 512
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 512
gguaaguucu guccaag                                                      17


<210> 513
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 513
gguaaguucu guccaa                                                       16


<210> 514
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 514
gguaaguucu gucca                                                        15


<210> 515
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 515
gguaaguucu gucc                                                         14


<210> 516
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 516
gguaaguucu guc                                                          13


<210> 517
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 517
gguaaguucu gu                                                           12


<210> 518
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 518
gguaaguucu g                                                            11


<210> 519
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 519
gguaaguucu                                                              10


<210> 520
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 520
gguaaguuc                                                                9


<210> 521
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 521
gguaaguu                                                                 8


<210> 522
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 522
cgguaaguuc uguccaagcc                                                   20


<210> 523
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 523
cgguaaguuc uguccaagc                                                    19


<210> 524
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 524
cgguaaguuc uguccaag                                                     18


<210> 525
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 525
cgguaaguuc uguccaa                                                      17


<210> 526
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 526
cgguaaguuc ugucca                                                       16


<210> 527
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 527
cgguaaguuc ugucc                                                        15


<210> 528
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 528
cgguaaguuc uguc                                                         14


<210> 529
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 529
cgguaaguuc ugu                                                          13


<210> 530
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 530
cgguaaguuc ug                                                           12


<210> 531
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 531
cgguaaguuc u                                                            11


<210> 532
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 532
cgguaaguuc                                                              10


<210> 533
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 533
cgguaaguu                                                                9


<210> 534
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 534
cgguaagu                                                                 8


<210> 535
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 535
ucgguaaguu cuguccaagc                                                   20


<210> 536
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 536
ucgguaaguu cuguccaag                                                    19


<210> 537
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 537
ucgguaaguu cuguccaa                                                     18


<210> 538
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 538
ucgguaaguu cugucca                                                      17


<210> 539
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 539
ucgguaaguu cugucc                                                       16


<210> 540
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 540
ucgguaaguu cuguc                                                        15


<210> 541
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 541
ucgguaaguu cugu                                                         14


<210> 542
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 542
ucgguaaguu cug                                                          13


<210> 543
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 543
ucgguaaguu cu                                                           12


<210> 544
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 544
ucgguaaguu c                                                            11


<210> 545
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 545
ucgguaaguu                                                              10


<210> 546
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 546
ucgguaagu                                                                9


<210> 547
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 547
gucgguaagu ucuguccaag                                                   20


<210> 548
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 548
gucgguaagu ucuguccaa                                                    19


<210> 549
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 549
gucgguaagu ucugucca                                                     18


<210> 550
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 550
gucgguaagu ucugucc                                                      17


<210> 551
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 551
gucgguaagu ucuguc                                                       16


<210> 552
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 552
gucgguaagu ucugu                                                        15


<210> 553
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 553
gucgguaagu ucug                                                         14


<210> 554
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 554
gucgguaagu ucu                                                          13


<210> 555
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 555
gucgguaagu uc                                                           12


<210> 556
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 556
gucgguaagu u                                                            11


<210> 557
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 557
gucgguaagu                                                              10


<210> 558
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 558
agucgguaag uucuguccaa                                                   20


<210> 559
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 559
agucgguaag uucugucca                                                    19


<210> 560
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 560
agucgguaag uucuguc                                                      17


<210> 561
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 561
agucgguaag uucugu                                                       16


<210> 562
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 562
agucgguaag uucug                                                        15


<210> 563
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 563
agucgguaag uucu                                                         14


<210> 564
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 564
agucgguaag uuc                                                          13


<210> 565
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 565
agucgguaag uu                                                           12


<210> 566
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 566
agucgguaag u                                                            11


<210> 567
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 567
cagucgguaa guucugucca                                                   20


<210> 568
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 568
cagucgguaa guucugucc                                                    19


<210> 569
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 569
cagucgguaa guucuguc                                                     18


<210> 570
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 570
cagucgguaa guucugu                                                      17


<210> 571
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 571
cagucgguaa guucug                                                       16


<210> 572
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 572
cagucgguaa guucu                                                        15


<210> 573
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 573
cagucgguaa guuc                                                         14


<210> 574
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 574
cagucgguaa guu                                                          13


<210> 575
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 575
cagucgguaa gu                                                           12


<210> 576
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 576
ccagucggua aguucugucc                                                   20


<210> 577
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 577
ccagucggua aguucuguc                                                    19


<210> 578
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 578
ccagucggua aguucugu                                                     18


<210> 579
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 579
ccagucggua aguucug                                                      17


<210> 580
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 580
ccagucggua aguucu                                                       16


<210> 581
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 581
ccagucggua aguuc                                                        15


<210> 582
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 582
ccagucggua aguu                                                         14


<210> 583
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 583
ccagucggua agu                                                          13


<210> 584
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 584
gccagucggu aaguucuguc                                                   20


<210> 585
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 585
gccagucggu aaguucugu                                                    19


<210> 586
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 586
gccagucggu aaguucug                                                     18


<210> 587
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 587
gccagucggu aaguucu                                                      17


<210> 588
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 588
gccagucggu aaguuc                                                       16


<210> 589
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 589
gccagucggu aaguu                                                        15


<210> 590
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 590
gccagucggu aagu                                                         14


<210> 591
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 591
ucaaggaaga uggcauuucu                                                   20


<210> 592
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 592
ucaaggaaga uggcauuucu ag                                                22


<210> 593
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 593
ucaaggaaga uggcau                                                       16


<210> 594
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 594
gaagauggca uuucu                                                        15


<210> 595
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 595
ucaaggaaga uggcauuucu a                                                 21


<210> 596
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 596
ucaaggaaga uggcauuuc                                                    19


<210> 597
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 597
ucaaggaaga uggcauuu                                                     18


<210> 598
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 598
ucaaggaaga uggcauu                                                      17


<210> 599
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 599
ucaaggaaga uggca                                                        15


<210> 600
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 600
ucaaggaaga uggc                                                         14


<210> 601
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 601
ucaaggaaga ugg                                                          13


<210> 602
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 602
ucaaggaaga ug                                                           12


<210> 603
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 603
ucaaggaaga u                                                            11


<210> 604
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 604
ucaaggaaga                                                              10


<210> 605
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 605
ucaaggaag                                                                9


<210> 606
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 606
caaggaagau ggcauuucua g                                                 21


<210> 607
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 607
caaggaagau ggcauuucua                                                   20


<210> 608
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 608
caaggaagau ggcauuucu                                                    19


<210> 609
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 609
caaggaagau ggcauuuc                                                     18


<210> 610
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 610
caaggaagau ggcauuu                                                      17


<210> 611
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 611
caaggaagau ggcauu                                                       16


<210> 612
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 612
caaggaagau ggcau                                                        15


<210> 613
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 613
caaggaagau ggca                                                         14


<210> 614
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 614
caaggaagau ggc                                                          13


<210> 615
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 615
caaggaagau gg                                                           12


<210> 616
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 616
caaggaagau g                                                            11


<210> 617
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 617
caaggaagau                                                              10


<210> 618
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 618
caaggaaga                                                                9


<210> 619
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 619
caaggaag                                                                 8


<210> 620
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 620
aaggaagaug gcauuucuag                                                   20


<210> 621
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 621
aaggaagaug gcauuucua                                                    19


<210> 622
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 622
aaggaagaug gcauuucu                                                     18


<210> 623
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 623
aaggaagaug gcauuuc                                                      17


<210> 624
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 624
aaggaagaug gcauuu                                                       16


<210> 625
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 625
aaggaagaug gcauu                                                        15


<210> 626
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 626
aaggaagaug gcau                                                         14


<210> 627
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 627
aaggaagaug gca                                                          13


<210> 628
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 628
aaggaagaug gc                                                           12


<210> 629
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 629
aaggaagaug g                                                            11


<210> 630
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 630
aaggaagaug                                                              10


<210> 631
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 631
aaggaagau                                                                9


<210> 632
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 632
aaggaaga                                                                 8


<210> 633
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 633
aggaagaugg cauuucuag                                                    19


<210> 634
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 634
aggaagaugg cauuucua                                                     18


<210> 635
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 635
aggaagaugg cauuucu                                                      17


<210> 636
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 636
aggaagaugg cauuuc                                                       16


<210> 637
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 637
aggaagaugg cauuu                                                        15


<210> 638
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 638
aggaagaugg cauu                                                         14


<210> 639
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 639
aggaagaugg cau                                                          13


<210> 640
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 640
aggaagaugg ca                                                           12


<210> 641
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 641
aggaagaugg                                                              10


<210> 642
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 642
aggaagaug                                                                9


<210> 643
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 643
aggaagau                                                                 8


<210> 644
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 644
ggaagauggc auuucuag                                                     18


<210> 645
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 645
ggaagauggc auuucua                                                      17


<210> 646
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 646
ggaagauggc auuucu                                                       16


<210> 647
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 647
ggaagauggc auuuc                                                        15


<210> 648
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 648
ggaagauggc auuu                                                         14


<210> 649
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 649
ggaagauggc auu                                                          13


<210> 650
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 650
ggaagauggc au                                                           12


<210> 651
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 651
ggaagauggc a                                                            11


<210> 652
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 652
ggaagauggc                                                              10


<210> 653
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 653
ggaagaug                                                                 8


<210> 654
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 654
gaagauggca uuucuag                                                      17


<210> 655
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 655
gaagauggca uuucua                                                       16


<210> 656
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 656
gaagauggca uuuc                                                         14


<210> 657
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 657
gaagauggca uuu                                                          13


<210> 658
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 658
gaagauggca uu                                                           12


<210> 659
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 659
gaagauggca u                                                            11


<210> 660
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 660
gaagauggca                                                              10


<210> 661
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 661
gaagauggc                                                                9


<210> 662
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 662
gaagaugg                                                                 8


<210> 663
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 663
aagauggcau uucuag                                                       16


<210> 664
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 664
aagauggcau uucua                                                        15


<210> 665
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 665
aagauggcau uucu                                                         14


<210> 666
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 666
aagauggcau uuc                                                          13


<210> 667
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 667
aagauggcau uu                                                           12


<210> 668
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 668
aagauggcau u                                                            11


<210> 669
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 669
aagauggcau                                                              10


<210> 670
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 670
aagauggca                                                                9


<210> 671
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 671
aagauggc                                                                 8


<210> 672
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 672
agauggcauu ucuag                                                        15


<210> 673
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 673
agauggcauu ucua                                                         14


<210> 674
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 674
agauggcauu ucu                                                          13


<210> 675
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 675
agauggcauu uc                                                           12


<210> 676
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 676
agauggcauu u                                                            11


<210> 677
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 677
agauggcauu                                                              10


<210> 678
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 678
agauggcau                                                                9


<210> 679
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 679
agauggca                                                                 8


<210> 680
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 680
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 681
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 681
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 682
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 682
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 683
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 683
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 684
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 684
cuccaacauc aaggaagaug gcauuu                                            26


<210> 685
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 685
cuccaacauc aaggaagaug gcauu                                             25


<210> 686
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 686
cuccaacauc aaggaagaug gcau                                              24


<210> 687
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 687
cuccaacauc aaggaagaug gca                                               23


<210> 688
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 688
cuccaacauc aaggaagaug gc                                                22


<210> 689
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 689
cuccaacauc aaggaagaug g                                                 21


<210> 690
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 690
cuccaacauc aaggaagaug                                                   20


<210> 691
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 691
cuccaacauc aaggaagau                                                    19


<210> 692
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 692
cuccaacauc aaggaaga                                                     18


<210> 693
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 693
cuccaacauc aaggaag                                                      17


<210> 694
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 694
uccaacauca aggaagaugg cauuucuag                                         29


<210> 695
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 695
uccaacauca aggaagaugg cauuucua                                          28


<210> 696
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 696
uccaacauca aggaagaugg cauuucu                                           27


<210> 697
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 697
uccaacauca aggaagaugg cauuuc                                            26


<210> 698
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 698
uccaacauca aggaagaugg cauuu                                             25


<210> 699
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 699
uccaacauca aggaagaugg cauu                                              24


<210> 700
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 700
uccaacauca aggaagaugg cau                                               23


<210> 701
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 701
uccaacauca aggaagaugg ca                                                22


<210> 702
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 702
uccaacauca aggaagaugg c                                                 21


<210> 703
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 703
uccaacauca aggaagaugg                                                   20


<210> 704
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 704
uccaacauca aggaagaug                                                    19


<210> 705
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 705
uccaacauca aggaagau                                                     18


<210> 706
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 706
uccaacauca aggaaga                                                      17


<210> 707
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 707
uccaacauca aggaag                                                       16


<210> 708
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 708
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 709
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 709
ccaacaucaa ggaagauggc auuucua                                           27


<210> 710
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 710
ccaacaucaa ggaagauggc auuucu                                            26


<210> 711
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 711
ccaacaucaa ggaagauggc auuuc                                             25


<210> 712
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 712
ccaacaucaa ggaagauggc auuu                                              24


<210> 713
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 713
ccaacaucaa ggaagauggc auu                                               23


<210> 714
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 714
ccaacaucaa ggaagauggc au                                                22


<210> 715
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 715
ccaacaucaa ggaagauggc a                                                 21


<210> 716
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 716
ccaacaucaa ggaagauggc                                                   20


<210> 717
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 717
ccaacaucaa ggaagaugg                                                    19


<210> 718
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 718
ccaacaucaa ggaagaug                                                     18


<210> 719
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 719
ccaacaucaa ggaagau                                                      17


<210> 720
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 720
ccaacaucaa ggaaga                                                       16


<210> 721
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 721
ccaacaucaa ggaag                                                        15


<210> 722
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 722
caacaucaag gaagauggca uuucuag                                           27


<210> 723
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 723
caacaucaag gaagauggca uuucua                                            26


<210> 724
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 724
caacaucaag gaagauggca uuucu                                             25


<210> 725
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 725
caacaucaag gaagauggca uuuc                                              24


<210> 726
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 726
caacaucaag gaagauggca uuu                                               23


<210> 727
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 727
caacaucaag gaagauggca uu                                                22


<210> 728
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 728
caacaucaag gaagauggca u                                                 21


<210> 729
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 729
caacaucaag gaagauggca                                                   20


<210> 730
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 730
caacaucaag gaagauggc                                                    19


<210> 731
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 731
caacaucaag gaagaugg                                                     18


<210> 732
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 732
caacaucaag gaagaug                                                      17


<210> 733
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 733
caacaucaag gaagau                                                       16


<210> 734
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 734
caacaucaag gaaga                                                        15


<210> 735
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 735
caacaucaag gaag                                                         14


<210> 736
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 736
aacaucaagg aagauggcau uucuag                                            26


<210> 737
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 737
aacaucaagg aagauggcau uucua                                             25


<210> 738
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 738
aacaucaagg aagauggcau uucu                                              24


<210> 739
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 739
aacaucaagg aagauggcau uuc                                               23


<210> 740
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 740
aacaucaagg aagauggcau uu                                                22


<210> 741
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 741
aacaucaagg aagauggcau u                                                 21


<210> 742
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 742
aacaucaagg aagauggcau                                                   20


<210> 743
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 743
aacaucaagg aagauggca                                                    19


<210> 744
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 744
aacaucaagg aagauggc                                                     18


<210> 745
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 745
aacaucaagg aagaugg                                                      17


<210> 746
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 746
aacaucaagg aagaug                                                       16


<210> 747
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 747
aacaucaagg aagau                                                        15


<210> 748
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 748
aacaucaagg aaga                                                         14


<210> 749
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 749
aacaucaagg aag                                                          13


<210> 750
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 750
acaucaagga agauggcauu ucuag                                             25


<210> 751
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 751
acaucaagga agauggcauu ucua                                              24


<210> 752
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 752
acaucaagga agauggcauu ucu                                               23


<210> 753
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 753
acaucaagga agauggcauu uc                                                22


<210> 754
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 754
acaucaagga agauggcauu u                                                 21


<210> 755
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 755
acaucaagga agauggcauu                                                   20


<210> 756
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 756
acaucaagga agauggcau                                                    19


<210> 757
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 757
acaucaagga agauggca                                                     18


<210> 758
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 758
acaucaagga agauggc                                                      17


<210> 759
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 759
acaucaagga agaugg                                                       16


<210> 760
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 760
acaucaagga agaug                                                        15


<210> 761
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 761
acaucaagga agau                                                         14


<210> 762
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 762
acaucaagga aga                                                          13


<210> 763
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 763
acaucaagga ag                                                           12


<210> 764
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 764
caucaaggaa gauggcauuu cuag                                              24


<210> 765
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 765
caucaaggaa gauggcauuu cua                                               23


<210> 766
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 766
caucaaggaa gauggcauuu cu                                                22


<210> 767
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 767
caucaaggaa gauggcauuu c                                                 21


<210> 768
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 768
caucaaggaa gauggcauuu                                                   20


<210> 769
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 769
caucaaggaa gauggcauu                                                    19


<210> 770
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 770
caucaaggaa gauggcau                                                     18


<210> 771
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 771
caucaaggaa gauggca                                                      17


<210> 772
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 772
caucaaggaa gauggc                                                       16


<210> 773
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 773
caucaaggaa gaugg                                                        15


<210> 774
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 774
caucaaggaa gaug                                                         14


<210> 775
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 775
caucaaggaa gau                                                          13


<210> 776
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 776
caucaaggaa ga                                                           12


<210> 777
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 777
caucaaggaa g                                                            11


<210> 778
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 778
aucaaggaag auggcauuuc uag                                               23


<210> 779
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 779
aucaaggaag auggcauuuc ua                                                22


<210> 780
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 780
aucaaggaag auggcauuuc u                                                 21


<210> 781
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 781
aucaaggaag auggcauuuc                                                   20


<210> 782
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 782
aucaaggaag auggcauuu                                                    19


<210> 783
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 783
aucaaggaag auggcauu                                                     18


<210> 784
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 784
aucaaggaag auggcau                                                      17


<210> 785
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 785
aucaaggaag auggca                                                       16


<210> 786
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 786
aucaaggaag auggc                                                        15


<210> 787
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 787
aucaaggaag augg                                                         14


<210> 788
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 788
aucaaggaag aug                                                          13


<210> 789
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 789
aucaaggaag au                                                           12


<210> 790
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 790
aucaaggaag a                                                            11


<210> 791
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 791
aucaaggaag                                                              10


<210> 792
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 792
ccagagcagg uaccuccaac auc                                               23


<210> 793
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 793
ccagagcagg uaccucca                                                     18


<210> 794
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 794
ccucugugau uuuauaacuu gau                                               23


<210> 795
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 795
ucacccacca ucacccu                                                      17


<210> 796
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 796
ugauauccuc aaggucaccc                                                   20


<210> 797
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 797
cugcuugaug aucaucucgu ug                                                22


<210> 798
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 798
cugcuugaug aucaucuc                                                     18


<210> 799
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 799
guuuccuuag uaaccacag                                                    19


<210> 800
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 800
guuuccuuag uaaccac                                                      17


<210> 801
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 801
ucaaggaaga uggcauuucu                                                   20


<210> 802
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 802
ucaaggaaga uggcauuucu ag                                                22


<210> 803
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 803
gguaaguucu guccaagc                                                     18


<210> 804
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 804
guaaguucug uccaagcc                                                     18


<210> 805
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 805
agucgguaag uucugucc                                                     18


<210> 806
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 806
cuguccaagc ccgguuga                                                     18


<210> 807
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 807
uaaguucugu ccaag                                                        15


<210> 808
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 808
uucuguccaa gcccgguuga                                                   20


<210> 809
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 809
uucuguccaa gcccgguug                                                    19


<210> 810
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 810
uucuguccaa gcccgguu                                                     18


<210> 811
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 811
uucuguccaa gcccggu                                                      17


<210> 812
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 812
uucuguccaa gcccgg                                                       16


<210> 813
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 813
uucuguccaa gcccg                                                        15


<210> 814
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 814
uucuguccaa gccc                                                         14


<210> 815
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 815
uucuguccaa gcc                                                          13


<210> 816
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 816
uucuguccaa gc                                                           12


<210> 817
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 817
uucuguccaa g                                                            11


<210> 818
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 818
uucuguccaa                                                              10


<210> 819
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 819
uucugucca                                                                9


<210> 820
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 820
uucugucc                                                                 8


<210> 821
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 821
ucuguccaag cccgguuga                                                    19


<210> 822
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 822
ucuguccaag cccgguug                                                     18


<210> 823
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 823
ucuguccaag cccgguu                                                      17


<210> 824
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 824
ucuguccaag cccggu                                                       16


<210> 825
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 825
ucuguccaag cccgg                                                        15


<210> 826
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 826
ucuguccaag cccg                                                         14


<210> 827
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 827
ucuguccaag ccc                                                          13


<210> 828
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 828
ucuguccaag cc                                                           12


<210> 829
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 829
ucuguccaag c                                                            11


<210> 830
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 830
ucuguccaag                                                              10


<210> 831
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 831
ucuguccaa                                                                9


<210> 832
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 832
ucugucca                                                                 8


<210> 833
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 833
cuguccaagc ccgguug                                                      17


<210> 834
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 834
cuguccaagc ccgguu                                                       16


<210> 835
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 835
cuguccaagc ccggu                                                        15


<210> 836
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 836
cuguccaagc ccgg                                                         14


<210> 837
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 837
cuguccaagc ccg                                                          13


<210> 838
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 838
cuguccaagc cc                                                           12


<210> 839
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 839
cuguccaagc c                                                            11


<210> 840
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 840
cuguccaagc                                                              10


<210> 841
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 841
cuguccaag                                                                9


<210> 842
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 842
cuguccaa                                                                 8


<210> 843
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 843
guucugucca agcccgguug                                                   20


<210> 844
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 844
guucugucca agcccgguu                                                    19


<210> 845
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 845
guucugucca agcccggu                                                     18


<210> 846
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 846
guucugucca agcccgg                                                      17


<210> 847
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 847
guucugucca agcccg                                                       16


<210> 848
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 848
guucugucca agccc                                                        15


<210> 849
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 849
guucugucca agcc                                                         14


<210> 850
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 850
guucugucca agc                                                          13


<210> 851
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 851
guucugucca ag                                                           12


<210> 852
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 852
guucugucca a                                                            11


<210> 853
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 853
guucugucca                                                              10


<210> 854
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 854
guucugucc                                                                9


<210> 855
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 855
guucuguc                                                                 8


<210> 856
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 856
aguucugucc aagcccgguu                                                   20


<210> 857
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 857
aguucugucc aagcccggu                                                    19


<210> 858
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 858
aguucugucc aagcccgg                                                     18


<210> 859
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 859
aguucugucc aagcccg                                                      17


<210> 860
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 860
aguucugucc aagccc                                                       16


<210> 861
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 861
aguucugucc aagcc                                                        15


<210> 862
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 862
aguucugucc aagc                                                         14


<210> 863
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 863
aguucugucc aag                                                          13


<210> 864
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 864
aguucugucc aa                                                           12


<210> 865
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 865
aguucugucc a                                                            11


<210> 866
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 866
aguucugucc                                                              10


<210> 867
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 867
aguucuguc                                                                9


<210> 868
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 868
aguucugu                                                                 8


<210> 869
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 869
aaguucuguc caagcccggu                                                   20


<210> 870
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 870
aaguucuguc caagcccgg                                                    19


<210> 871
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 871
aaguucuguc caagcccg                                                     18


<210> 872
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 872
aaguucuguc caagccc                                                      17


<210> 873
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 873
aaguucuguc caagcc                                                       16


<210> 874
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 874
aaguucuguc caagc                                                        15


<210> 875
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 875
aaguucuguc caag                                                         14


<210> 876
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 876
aaguucuguc caa                                                          13


<210> 877
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 877
aaguucuguc ca                                                           12


<210> 878
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 878
aaguucuguc c                                                            11


<210> 879
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 879
aaguucuguc                                                              10


<210> 880
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 880
aaguucugu                                                                9


<210> 881
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 881
aaguucug                                                                 8


<210> 882
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 882
uaaguucugu ccaagcccgg                                                   20


<210> 883
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 883
uaaguucugu ccaagcccg                                                    19


<210> 884
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 884
uaaguucugu ccaagccc                                                     18


<210> 885
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 885
uaaguucugu ccaagcc                                                      17


<210> 886
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 886
uaaguucugu ccaagc                                                       16


<210> 887
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 887
uaaguucugu ccaa                                                         14


<210> 888
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 888
uaaguucugu cca                                                          13


<210> 889
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 889
uaaguucugu cc                                                           12


<210> 890
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 890
uaaguucugu c                                                            11


<210> 891
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 891
uaaguucugu                                                              10


<210> 892
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 892
uaaguucug                                                                9


<210> 893
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 893
uaaguucu                                                                 8


<210> 894
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 894
guaaguucug uccaagcccg                                                   20


<210> 895
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 895
guaaguucug uccaagccc                                                    19


<210> 896
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 896
guaaguucug uccaagc                                                      17


<210> 897
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 897
guaaguucug uccaag                                                       16


<210> 898
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 898
guaaguucug uccaa                                                        15


<210> 899
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 899
guaaguucug ucca                                                         14


<210> 900
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 900
guaaguucug ucc                                                          13


<210> 901
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 901
guaaguucug uc                                                           12


<210> 902
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 902
guaaguucug u                                                            11


<210> 903
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 903
guaaguucug                                                              10


<210> 904
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 904
guaaguucu                                                                9


<210> 905
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 905
guaaguuc                                                                 8


<210> 906
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 906
gguaaguucu guccaagccc                                                   20


<210> 907
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 907
gguaaguucu guccaagcc                                                    19


<210> 908
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 908
gguaaguucu guccaag                                                      17


<210> 909
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 909
gguaaguucu guccaa                                                       16


<210> 910
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 910
gguaaguucu gucca                                                        15


<210> 911
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 911
gguaaguucu gucc                                                         14


<210> 912
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 912
gguaaguucu guc                                                          13


<210> 913
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 913
gguaaguucu gu                                                           12


<210> 914
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 914
gguaaguucu g                                                            11


<210> 915
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 915
gguaaguucu                                                              10


<210> 916
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 916
gguaaguuc                                                                9


<210> 917
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 917
gguaaguu                                                                 8


<210> 918
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 918
cgguaaguuc uguccaagcc                                                   20


<210> 919
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 919
cgguaaguuc uguccaagc                                                    19


<210> 920
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 920
cgguaaguuc uguccaag                                                     18


<210> 921
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 921
cgguaaguuc uguccaa                                                      17


<210> 922
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 922
cgguaaguuc ugucca                                                       16


<210> 923
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 923
cgguaaguuc ugucc                                                        15


<210> 924
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 924
cgguaaguuc uguc                                                         14


<210> 925
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 925
cgguaaguuc ugu                                                          13


<210> 926
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 926
cgguaaguuc ug                                                           12


<210> 927
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 927
cgguaaguuc u                                                            11


<210> 928
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 928
cgguaaguuc                                                              10


<210> 929
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 929
cgguaaguu                                                                9


<210> 930
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 930
cgguaagu                                                                 8


<210> 931
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 931
ucgguaaguu cuguccaagc                                                   20


<210> 932
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 932
ucgguaaguu cuguccaag                                                    19


<210> 933
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 933
ucgguaaguu cuguccaa                                                     18


<210> 934
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 934
ucgguaaguu cugucca                                                      17


<210> 935
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 935
ucgguaaguu cugucc                                                       16


<210> 936
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 936
ucgguaaguu cuguc                                                        15


<210> 937
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 937
ucgguaaguu cugu                                                         14


<210> 938
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 938
ucgguaaguu cug                                                          13


<210> 939
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 939
ucgguaaguu cu                                                           12


<210> 940
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 940
ucgguaaguu c                                                            11


<210> 941
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 941
ucgguaaguu                                                              10


<210> 942
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 942
ucgguaagu                                                                9


<210> 943
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 943
gucgguaagu ucuguccaag                                                   20


<210> 944
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 944
gucgguaagu ucuguccaa                                                    19


<210> 945
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 945
gucgguaagu ucugucca                                                     18


<210> 946
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 946
gucgguaagu ucugucc                                                      17


<210> 947
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 947
gucgguaagu ucuguc                                                       16


<210> 948
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 948
gucgguaagu ucugu                                                        15


<210> 949
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 949
gucgguaagu ucug                                                         14


<210> 950
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 950
gucgguaagu ucu                                                          13


<210> 951
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 951
gucgguaagu uc                                                           12


<210> 952
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 952
gucgguaagu u                                                            11


<210> 953
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 953
gucgguaagu                                                              10


<210> 954
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 954
agucgguaag uucuguccaa                                                   20


<210> 955
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 955
agucgguaag uucugucca                                                    19


<210> 956
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 956
agucgguaag uucuguc                                                      17


<210> 957
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 957
agucgguaag uucugu                                                       16


<210> 958
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 958
agucgguaag uucug                                                        15


<210> 959
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 959
agucgguaag uucu                                                         14


<210> 960
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 960
agucgguaag uuc                                                          13


<210> 961
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 961
agucgguaag uu                                                           12


<210> 962
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 962
agucgguaag u                                                            11


<210> 963
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 963
cagucgguaa guucugucca                                                   20


<210> 964
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 964
cagucgguaa guucugucc                                                    19


<210> 965
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 965
cagucgguaa guucuguc                                                     18


<210> 966
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 966
cagucgguaa guucugu                                                      17


<210> 967
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 967
cagucgguaa guucug                                                       16


<210> 968
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 968
cagucgguaa guucu                                                        15


<210> 969
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 969
cagucgguaa guuc                                                         14


<210> 970
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 970
cagucgguaa guu                                                          13


<210> 971
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 971
cagucgguaa gu                                                           12


<210> 972
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 972
ccagucggua aguucugucc                                                   20


<210> 973
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 973
ccagucggua aguucuguc                                                    19


<210> 974
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 974
ccagucggua aguucugu                                                     18


<210> 975
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 975
ccagucggua aguucug                                                      17


<210> 976
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 976
ccagucggua aguucu                                                       16


<210> 977
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 977
ccagucggua aguuc                                                        15


<210> 978
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 978
ccagucggua aguu                                                         14


<210> 979
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 979
ccagucggua agu                                                          13


<210> 980
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 980
gccagucggu aaguucuguc                                                   20


<210> 981
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 981
gccagucggu aaguucugu                                                    19


<210> 982
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 982
gccagucggu aaguucug                                                     18


<210> 983
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 983
gccagucggu aaguucu                                                      17


<210> 984
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 984
gccagucggu aaguuc                                                       16


<210> 985
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 985
gccagucggu aaguu                                                        15


<210> 986
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 986
gccagucggu aagu                                                         14


<210> 987
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 987
ucaaggaaga uggcauuucu                                                   20


<210> 988
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 988
ucaaggaaga uggcauuucu ag                                                22


<210> 989
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 989
ucaaggaaga uggcau                                                       16


<210> 990
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 990
gaagauggca uuucu                                                        15


<210> 991
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 991
ucaaggaaga uggcauuucu a                                                 21


<210> 992
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 992
ucaaggaaga uggcauuuc                                                    19


<210> 993
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 993
ucaaggaaga uggcauuu                                                     18


<210> 994
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 994
ucaaggaaga uggcauu                                                      17


<210> 995
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 995
ucaaggaaga uggca                                                        15


<210> 996
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 996
ucaaggaaga uggc                                                         14


<210> 997
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 997
ucaaggaaga ugg                                                          13


<210> 998
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 998
ucaaggaaga ug                                                           12


<210> 999
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 999
ucaaggaaga u                                                            11


<210> 1000
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1000
ucaaggaaga                                                              10


<210> 1001
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1001
ucaaggaag                                                                9


<210> 1002
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1002
caaggaagau ggcauuucua g                                                 21


<210> 1003
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1003
caaggaagau ggcauuucua                                                   20


<210> 1004
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1004
caaggaagau ggcauuucu                                                    19


<210> 1005
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1005
caaggaagau ggcauuuc                                                     18


<210> 1006
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1006
caaggaagau ggcauuu                                                      17


<210> 1007
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1007
caaggaagau ggcauu                                                       16


<210> 1008
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1008
caaggaagau ggcau                                                        15


<210> 1009
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1009
caaggaagau ggca                                                         14


<210> 1010
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1010
caaggaagau ggc                                                          13


<210> 1011
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1011
caaggaagau gg                                                           12


<210> 1012
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1012
caaggaagau g                                                            11


<210> 1013
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1013
caaggaagau                                                              10


<210> 1014
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1014
caaggaaga                                                                9


<210> 1015
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1015
caaggaag                                                                 8


<210> 1016
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1016
aaggaagaug gcauuucuag                                                   20


<210> 1017
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1017
aaggaagaug gcauuucua                                                    19


<210> 1018
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1018
aaggaagaug gcauuucu                                                     18


<210> 1019
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1019
aaggaagaug gcauuuc                                                      17


<210> 1020
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1020
aaggaagaug gcauuu                                                       16


<210> 1021
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1021
aaggaagaug gcauu                                                        15


<210> 1022
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1022
aaggaagaug gcau                                                         14


<210> 1023
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1023
aaggaagaug gca                                                          13


<210> 1024
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1024
aaggaagaug gc                                                           12


<210> 1025
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1025
aaggaagaug g                                                            11


<210> 1026
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1026
aaggaagaug                                                              10


<210> 1027
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1027
aaggaagau                                                                9


<210> 1028
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1028
aaggaaga                                                                 8


<210> 1029
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1029
aggaagaugg cauuucuag                                                    19


<210> 1030
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1030
aggaagaugg cauuucua                                                     18


<210> 1031
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1031
aggaagaugg cauuucu                                                      17


<210> 1032
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1032
aggaagaugg cauuuc                                                       16


<210> 1033
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1033
aggaagaugg cauuu                                                        15


<210> 1034
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1034
aggaagaugg cauu                                                         14


<210> 1035
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1035
aggaagaugg cau                                                          13


<210> 1036
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1036
aggaagaugg ca                                                           12


<210> 1037
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1037
aggaagaugg                                                              10


<210> 1038
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1038
aggaagaug                                                                9


<210> 1039
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1039
aggaagau                                                                 8


<210> 1040
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1040
ggaagauggc auuucuag                                                     18


<210> 1041
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1041
ggaagauggc auuucua                                                      17


<210> 1042
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1042
ggaagauggc auuucu                                                       16


<210> 1043
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1043
ggaagauggc auuuc                                                        15


<210> 1044
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1044
ggaagauggc auuu                                                         14


<210> 1045
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1045
ggaagauggc auu                                                          13


<210> 1046
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1046
ggaagauggc au                                                           12


<210> 1047
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1047
ggaagauggc a                                                            11


<210> 1048
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1048
ggaagauggc                                                              10


<210> 1049
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1049
ggaagaug                                                                 8


<210> 1050
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1050
gaagauggca uuucuag                                                      17


<210> 1051
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1051
gaagauggca uuucua                                                       16


<210> 1052
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1052
gaagauggca uuuc                                                         14


<210> 1053
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1053
gaagauggca uuu                                                          13


<210> 1054
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1054
gaagauggca uu                                                           12


<210> 1055
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1055
gaagauggca u                                                            11


<210> 1056
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1056
gaagauggca                                                              10


<210> 1057
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1057
gaagauggc                                                                9


<210> 1058
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1058
gaagaugg                                                                 8


<210> 1059
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1059
aagauggcau uucuag                                                       16


<210> 1060
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1060
aagauggcau uucua                                                        15


<210> 1061
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1061
aagauggcau uucu                                                         14


<210> 1062
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1062
aagauggcau uuc                                                          13


<210> 1063
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1063
aagauggcau uu                                                           12


<210> 1064
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1064
aagauggcau u                                                            11


<210> 1065
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1065
aagauggcau                                                              10


<210> 1066
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1066
aagauggca                                                                9


<210> 1067
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1067
aagauggc                                                                 8


<210> 1068
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1068
agauggcauu ucuag                                                        15


<210> 1069
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1069
agauggcauu ucua                                                         14


<210> 1070
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1070
agauggcauu ucu                                                          13


<210> 1071
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1071
agauggcauu uc                                                           12


<210> 1072
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1072
agauggcauu u                                                            11


<210> 1073
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1073
agauggcauu                                                              10


<210> 1074
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1074
agauggcau                                                                9


<210> 1075
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1075
agauggca                                                                 8


<210> 1076
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1076
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 1077
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1077
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 1078
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1078
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 1079
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1079
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 1080
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1080
cuccaacauc aaggaagaug gcauuu                                            26


<210> 1081
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1081
cuccaacauc aaggaagaug gcauu                                             25


<210> 1082
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1082
cuccaacauc aaggaagaug gcau                                              24


<210> 1083
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1083
cuccaacauc aaggaagaug gca                                               23


<210> 1084
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1084
cuccaacauc aaggaagaug gc                                                22


<210> 1085
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1085
cuccaacauc aaggaagaug g                                                 21


<210> 1086
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1086
cuccaacauc aaggaagaug                                                   20


<210> 1087
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1087
cuccaacauc aaggaagau                                                    19


<210> 1088
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1088
cuccaacauc aaggaaga                                                     18


<210> 1089
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1089
cuccaacauc aaggaag                                                      17


<210> 1090
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1090
uccaacauca aggaagaugg cauuucuag                                         29


<210> 1091
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1091
uccaacauca aggaagaugg cauuucua                                          28


<210> 1092
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1092
uccaacauca aggaagaugg cauuucu                                           27


<210> 1093
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1093
uccaacauca aggaagaugg cauuuc                                            26


<210> 1094
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1094
uccaacauca aggaagaugg cauuu                                             25


<210> 1095
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1095
uccaacauca aggaagaugg cauu                                              24


<210> 1096
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1096
uccaacauca aggaagaugg cau                                               23


<210> 1097
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1097
uccaacauca aggaagaugg ca                                                22


<210> 1098
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1098
uccaacauca aggaagaugg c                                                 21


<210> 1099
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1099
uccaacauca aggaagaugg                                                   20


<210> 1100
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1100
uccaacauca aggaagaug                                                    19


<210> 1101
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1101
uccaacauca aggaagau                                                     18


<210> 1102
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1102
uccaacauca aggaaga                                                      17


<210> 1103
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1103
uccaacauca aggaag                                                       16


<210> 1104
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1104
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 1105
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1105
ccaacaucaa ggaagauggc auuucua                                           27


<210> 1106
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1106
ccaacaucaa ggaagauggc auuucu                                            26


<210> 1107
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1107
ccaacaucaa ggaagauggc auuuc                                             25


<210> 1108
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1108
ccaacaucaa ggaagauggc auuu                                              24


<210> 1109
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1109
ccaacaucaa ggaagauggc auu                                               23


<210> 1110
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1110
ccaacaucaa ggaagauggc au                                                22


<210> 1111
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1111
ccaacaucaa ggaagauggc a                                                 21


<210> 1112
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1112
ccaacaucaa ggaagauggc                                                   20


<210> 1113
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1113
ccaacaucaa ggaagaugg                                                    19


<210> 1114
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1114
ccaacaucaa ggaagaug                                                     18


<210> 1115
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1115
ccaacaucaa ggaagau                                                      17


<210> 1116
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1116
ccaacaucaa ggaaga                                                       16


<210> 1117
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1117
ccaacaucaa ggaag                                                        15


<210> 1118
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1118
caacaucaag gaagauggca uuucuag                                           27


<210> 1119
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1119
caacaucaag gaagauggca uuucua                                            26


<210> 1120
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1120
caacaucaag gaagauggca uuucu                                             25


<210> 1121
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1121
caacaucaag gaagauggca uuuc                                              24


<210> 1122
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1122
caacaucaag gaagauggca uuu                                               23


<210> 1123
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1123
caacaucaag gaagauggca uu                                                22


<210> 1124
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1124
caacaucaag gaagauggca u                                                 21


<210> 1125
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1125
caacaucaag gaagauggca                                                   20


<210> 1126
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1126
caacaucaag gaagauggc                                                    19


<210> 1127
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1127
caacaucaag gaagaugg                                                     18


<210> 1128
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1128
caacaucaag gaagaug                                                      17


<210> 1129
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1129
caacaucaag gaagau                                                       16


<210> 1130
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1130
caacaucaag gaaga                                                        15


<210> 1131
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1131
caacaucaag gaag                                                         14


<210> 1132
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1132
aacaucaagg aagauggcau uucuag                                            26


<210> 1133
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1133
aacaucaagg aagauggcau uucua                                             25


<210> 1134
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1134
aacaucaagg aagauggcau uucu                                              24


<210> 1135
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1135
aacaucaagg aagauggcau uuc                                               23


<210> 1136
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1136
aacaucaagg aagauggcau uu                                                22


<210> 1137
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1137
aacaucaagg aagauggcau u                                                 21


<210> 1138
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1138
aacaucaagg aagauggcau                                                   20


<210> 1139
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1139
aacaucaagg aagauggca                                                    19


<210> 1140
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1140
aacaucaagg aagauggc                                                     18


<210> 1141
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1141
aacaucaagg aagaugg                                                      17


<210> 1142
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1142
aacaucaagg aagaug                                                       16


<210> 1143
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1143
aacaucaagg aagau                                                        15


<210> 1144
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1144
aacaucaagg aaga                                                         14


<210> 1145
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1145
aacaucaagg aag                                                          13


<210> 1146
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1146
acaucaagga agauggcauu ucuag                                             25


<210> 1147
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1147
acaucaagga agauggcauu ucua                                              24


<210> 1148
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1148
acaucaagga agauggcauu ucu                                               23


<210> 1149
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1149
acaucaagga agauggcauu uc                                                22


<210> 1150
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1150
acaucaagga agauggcauu u                                                 21


<210> 1151
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1151
acaucaagga agauggcauu                                                   20


<210> 1152
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1152
acaucaagga agauggcau                                                    19


<210> 1153
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1153
acaucaagga agauggca                                                     18


<210> 1154
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1154
acaucaagga agauggc                                                      17


<210> 1155
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1155
acaucaagga agaugg                                                       16


<210> 1156
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1156
acaucaagga agaug                                                        15


<210> 1157
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1157
acaucaagga agau                                                         14


<210> 1158
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1158
acaucaagga aga                                                          13


<210> 1159
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1159
acaucaagga ag                                                           12


<210> 1160
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1160
caucaaggaa gauggcauuu cuag                                              24


<210> 1161
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1161
caucaaggaa gauggcauuu cua                                               23


<210> 1162
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1162
caucaaggaa gauggcauuu cu                                                22


<210> 1163
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1163
caucaaggaa gauggcauuu c                                                 21


<210> 1164
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1164
caucaaggaa gauggcauuu                                                   20


<210> 1165
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1165
caucaaggaa gauggcauu                                                    19


<210> 1166
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1166
caucaaggaa gauggcau                                                     18


<210> 1167
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1167
caucaaggaa gauggca                                                      17


<210> 1168
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1168
caucaaggaa gauggc                                                       16


<210> 1169
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1169
caucaaggaa gaugg                                                        15


<210> 1170
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1170
caucaaggaa gaug                                                         14


<210> 1171
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1171
caucaaggaa gau                                                          13


<210> 1172
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1172
caucaaggaa ga                                                           12


<210> 1173
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1173
caucaaggaa g                                                            11


<210> 1174
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1174
aucaaggaag auggcauuuc uag                                               23


<210> 1175
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1175
aucaaggaag auggcauuuc ua                                                22


<210> 1176
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1176
aucaaggaag auggcauuuc u                                                 21


<210> 1177
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1177
aucaaggaag auggcauuuc                                                   20


<210> 1178
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1178
aucaaggaag auggcauuu                                                    19


<210> 1179
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1179
aucaaggaag auggcauu                                                     18


<210> 1180
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1180
aucaaggaag auggcau                                                      17


<210> 1181
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1181
aucaaggaag auggca                                                       16


<210> 1182
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1182
aucaaggaag auggc                                                        15


<210> 1183
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1183
aucaaggaag augg                                                         14


<210> 1184
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1184
aucaaggaag aug                                                          13


<210> 1185
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1185
aucaaggaag au                                                           12


<210> 1186
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1186
aucaaggaag a                                                            11


<210> 1187
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1187
aucaaggaag                                                              10


<210> 1188
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1188
ccagagcagg uaccuccaac auc                                               23


<210> 1189
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1189
ccagagcagg uaccucca                                                     18


<210> 1190
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1190
ccucugugau uuuauaacuu gau                                               23


<210> 1191
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1191
ucacccacca ucacccu                                                      17


<210> 1192
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1192
ugauauccuc aaggucaccc                                                   20


<210> 1193
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1193
cugcuugaug aucaucucgu ug                                                22


<210> 1194
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1194
cugcuugaug aucaucuc                                                     18


<210> 1195
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1195
guuuccuuag uaaccacag                                                    19


<210> 1196
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1196
guuuccuuag uaaccac                                                      17


<210> 1197
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1197
ucaaggaaga uggcauuucu                                                   20


<210> 1198
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1198
ucaaggaaga uggcauuucu ag                                                22


<210> 1199
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1199
gguaaguucu guccaagc                                                     18


<210> 1200
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1200
guaaguucug uccaagcc                                                     18


<210> 1201
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1201
agucgguaag uucugucc                                                     18


<210> 1202
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1202
cuguccaagc ccgguuga                                                     18


<210> 1203
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1203
uaaguucugu ccaag                                                        15


<210> 1204
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1204
uucuguccaa gcccgguuga                                                   20


<210> 1205
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1205
uucuguccaa gcccgguug                                                    19


<210> 1206
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1206
uucuguccaa gcccgguu                                                     18


<210> 1207
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1207
uucuguccaa gcccggu                                                      17


<210> 1208
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1208
uucuguccaa gcccgg                                                       16


<210> 1209
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1209
uucuguccaa gcccg                                                        15


<210> 1210
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1210
uucuguccaa gccc                                                         14


<210> 1211
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1211
uucuguccaa gcc                                                          13


<210> 1212
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1212
uucuguccaa gc                                                           12


<210> 1213
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1213
uucuguccaa g                                                            11


<210> 1214
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1214
uucuguccaa                                                              10


<210> 1215
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1215
uucugucca                                                                9


<210> 1216
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1216
uucugucc                                                                 8


<210> 1217
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1217
ucuguccaag cccgguuga                                                    19


<210> 1218
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1218
ucuguccaag cccgguug                                                     18


<210> 1219
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1219
ucuguccaag cccgguu                                                      17


<210> 1220
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1220
ucuguccaag cccggu                                                       16


<210> 1221
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1221
ucuguccaag cccgg                                                        15


<210> 1222
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1222
ucuguccaag cccg                                                         14


<210> 1223
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1223
ucuguccaag ccc                                                          13


<210> 1224
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1224
ucuguccaag cc                                                           12


<210> 1225
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1225
ucuguccaag c                                                            11


<210> 1226
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1226
ucuguccaag                                                              10


<210> 1227
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1227
ucuguccaa                                                                9


<210> 1228
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1228
ucugucca                                                                 8


<210> 1229
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1229
cuguccaagc ccgguug                                                      17


<210> 1230
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1230
cuguccaagc ccgguu                                                       16


<210> 1231
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1231
cuguccaagc ccggu                                                        15


<210> 1232
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1232
cuguccaagc ccgg                                                         14


<210> 1233
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1233
cuguccaagc ccg                                                          13


<210> 1234
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1234
cuguccaagc cc                                                           12


<210> 1235
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1235
cuguccaagc c                                                            11


<210> 1236
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1236
cuguccaagc                                                              10


<210> 1237
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1237
cuguccaag                                                                9


<210> 1238
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1238
cuguccaa                                                                 8


<210> 1239
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1239
guucugucca agcccgguug                                                   20


<210> 1240
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1240
guucugucca agcccgguu                                                    19


<210> 1241
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1241
guucugucca agcccggu                                                     18


<210> 1242
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1242
guucugucca agcccgg                                                      17


<210> 1243
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1243
guucugucca agcccg                                                       16


<210> 1244
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1244
guucugucca agccc                                                        15


<210> 1245
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1245
guucugucca agcc                                                         14


<210> 1246
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1246
guucugucca agc                                                          13


<210> 1247
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1247
guucugucca ag                                                           12


<210> 1248
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1248
guucugucca a                                                            11


<210> 1249
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1249
guucugucca                                                              10


<210> 1250
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1250
guucugucc                                                                9


<210> 1251
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1251
guucuguc                                                                 8


<210> 1252
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1252
aguucugucc aagcccgguu                                                   20


<210> 1253
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1253
aguucugucc aagcccggu                                                    19


<210> 1254
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1254
aguucugucc aagcccgg                                                     18


<210> 1255
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1255
aguucugucc aagcccg                                                      17


<210> 1256
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1256
aguucugucc aagccc                                                       16


<210> 1257
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1257
aguucugucc aagcc                                                        15


<210> 1258
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1258
aguucugucc aagc                                                         14


<210> 1259
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1259
aguucugucc aag                                                          13


<210> 1260
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1260
aguucugucc aa                                                           12


<210> 1261
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1261
aguucugucc a                                                            11


<210> 1262
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1262
aguucugucc                                                              10


<210> 1263
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1263
aguucuguc                                                                9


<210> 1264
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1264
aguucugu                                                                 8


<210> 1265
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1265
aaguucuguc caagcccggu                                                   20


<210> 1266
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1266
aaguucuguc caagcccgg                                                    19


<210> 1267
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1267
aaguucuguc caagcccg                                                     18


<210> 1268
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1268
aaguucuguc caagccc                                                      17


<210> 1269
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1269
aaguucuguc caagcc                                                       16


<210> 1270
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1270
aaguucuguc caagc                                                        15


<210> 1271
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1271
aaguucuguc caag                                                         14


<210> 1272
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1272
aaguucuguc caa                                                          13


<210> 1273
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1273
aaguucuguc ca                                                           12


<210> 1274
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1274
aaguucuguc c                                                            11


<210> 1275
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1275
aaguucuguc                                                              10


<210> 1276
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1276
aaguucugu                                                                9


<210> 1277
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1277
aaguucug                                                                 8


<210> 1278
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1278
uaaguucugu ccaagcccgg                                                   20


<210> 1279
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1279
uaaguucugu ccaagcccg                                                    19


<210> 1280
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1280
uaaguucugu ccaagccc                                                     18


<210> 1281
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1281
uaaguucugu ccaagcc                                                      17


<210> 1282
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1282
uaaguucugu ccaagc                                                       16


<210> 1283
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1283
uaaguucugu ccaa                                                         14


<210> 1284
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1284
uaaguucugu cca                                                          13


<210> 1285
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1285
uaaguucugu cc                                                           12


<210> 1286
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1286
uaaguucugu c                                                            11


<210> 1287
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1287
uaaguucugu                                                              10


<210> 1288
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1288
uaaguucug                                                                9


<210> 1289
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1289
uaaguucu                                                                 8


<210> 1290
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1290
guaaguucug uccaagcccg                                                   20


<210> 1291
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1291
guaaguucug uccaagccc                                                    19


<210> 1292
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1292
guaaguucug uccaagc                                                      17


<210> 1293
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1293
guaaguucug uccaag                                                       16


<210> 1294
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1294
guaaguucug uccaa                                                        15


<210> 1295
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1295
guaaguucug ucca                                                         14


<210> 1296
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1296
guaaguucug ucc                                                          13


<210> 1297
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1297
guaaguucug uc                                                           12


<210> 1298
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1298
guaaguucug u                                                            11


<210> 1299
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1299
guaaguucug                                                              10


<210> 1300
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1300
guaaguucu                                                                9


<210> 1301
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1301
guaaguuc                                                                 8


<210> 1302
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1302
gguaaguucu guccaagccc                                                   20


<210> 1303
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1303
gguaaguucu guccaagcc                                                    19


<210> 1304
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1304
gguaaguucu guccaag                                                      17


<210> 1305
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1305
gguaaguucu guccaa                                                       16


<210> 1306
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1306
gguaaguucu gucca                                                        15


<210> 1307
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1307
gguaaguucu gucc                                                         14


<210> 1308
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1308
gguaaguucu guc                                                          13


<210> 1309
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1309
gguaaguucu gu                                                           12


<210> 1310
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1310
gguaaguucu g                                                            11


<210> 1311
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1311
gguaaguucu                                                              10


<210> 1312
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1312
gguaaguuc                                                                9


<210> 1313
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1313
gguaaguu                                                                 8


<210> 1314
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1314
cgguaaguuc uguccaagcc                                                   20


<210> 1315
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1315
cgguaaguuc uguccaagc                                                    19


<210> 1316
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1316
cgguaaguuc uguccaag                                                     18


<210> 1317
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1317
cgguaaguuc uguccaa                                                      17


<210> 1318
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1318
cgguaaguuc ugucca                                                       16


<210> 1319
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1319
cgguaaguuc ugucc                                                        15


<210> 1320
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1320
cgguaaguuc uguc                                                         14


<210> 1321
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1321
cgguaaguuc ugu                                                          13


<210> 1322
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1322
cgguaaguuc ug                                                           12


<210> 1323
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1323
cgguaaguuc u                                                            11


<210> 1324
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1324
cgguaaguuc                                                              10


<210> 1325
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1325
cgguaaguu                                                                9


<210> 1326
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1326
cgguaagu                                                                 8


<210> 1327
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1327
ucgguaaguu cuguccaagc                                                   20


<210> 1328
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1328
ucgguaaguu cuguccaag                                                    19


<210> 1329
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1329
ucgguaaguu cuguccaa                                                     18


<210> 1330
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1330
ucgguaaguu cugucca                                                      17


<210> 1331
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1331
ucgguaaguu cugucc                                                       16


<210> 1332
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1332
ucgguaaguu cuguc                                                        15


<210> 1333
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1333
ucgguaaguu cugu                                                         14


<210> 1334
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1334
ucgguaaguu cug                                                          13


<210> 1335
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1335
ucgguaaguu cu                                                           12


<210> 1336
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1336
ucgguaaguu c                                                            11


<210> 1337
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1337
ucgguaaguu                                                              10


<210> 1338
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1338
ucgguaagu                                                                9


<210> 1339
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1339
gucgguaagu ucuguccaag                                                   20


<210> 1340
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1340
gucgguaagu ucuguccaa                                                    19


<210> 1341
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1341
gucgguaagu ucugucca                                                     18


<210> 1342
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1342
gucgguaagu ucugucc                                                      17


<210> 1343
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1343
gucgguaagu ucuguc                                                       16


<210> 1344
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1344
gucgguaagu ucugu                                                        15


<210> 1345
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1345
gucgguaagu ucug                                                         14


<210> 1346
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1346
gucgguaagu ucu                                                          13


<210> 1347
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1347
gucgguaagu uc                                                           12


<210> 1348
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1348
gucgguaagu u                                                            11


<210> 1349
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1349
gucgguaagu                                                              10


<210> 1350
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1350
agucgguaag uucuguccaa                                                   20


<210> 1351
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1351
agucgguaag uucugucca                                                    19


<210> 1352
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1352
agucgguaag uucuguc                                                      17


<210> 1353
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1353
agucgguaag uucugu                                                       16


<210> 1354
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1354
agucgguaag uucug                                                        15


<210> 1355
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1355
agucgguaag uucu                                                         14


<210> 1356
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1356
agucgguaag uuc                                                          13


<210> 1357
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1357
agucgguaag uu                                                           12


<210> 1358
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1358
agucgguaag u                                                            11


<210> 1359
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1359
cagucgguaa guucugucca                                                   20


<210> 1360
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1360
cagucgguaa guucugucc                                                    19


<210> 1361
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1361
cagucgguaa guucuguc                                                     18


<210> 1362
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1362
cagucgguaa guucugu                                                      17


<210> 1363
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1363
cagucgguaa guucug                                                       16


<210> 1364
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1364
cagucgguaa guucu                                                        15


<210> 1365
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1365
cagucgguaa guuc                                                         14


<210> 1366
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1366
cagucgguaa guu                                                          13


<210> 1367
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1367
cagucgguaa gu                                                           12


<210> 1368
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1368
ccagucggua aguucugucc                                                   20


<210> 1369
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1369
ccagucggua aguucuguc                                                    19


<210> 1370
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1370
ccagucggua aguucugu                                                     18


<210> 1371
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1371
ccagucggua aguucug                                                      17


<210> 1372
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1372
ccagucggua aguucu                                                       16


<210> 1373
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1373
ccagucggua aguuc                                                        15


<210> 1374
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1374
ccagucggua aguu                                                         14


<210> 1375
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1375
ccagucggua agu                                                          13


<210> 1376
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1376
gccagucggu aaguucuguc                                                   20


<210> 1377
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1377
gccagucggu aaguucugu                                                    19


<210> 1378
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1378
gccagucggu aaguucug                                                     18


<210> 1379
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1379
gccagucggu aaguucu                                                      17


<210> 1380
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1380
gccagucggu aaguuc                                                       16


<210> 1381
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1381
gccagucggu aaguu                                                        15


<210> 1382
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1382
gccagucggu aagu                                                         14


<210> 1383
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1383
ucaaggaaga uggcauuucu                                                   20


<210> 1384
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1384
ucaaggaaga uggcauuucu ag                                                22


<210> 1385
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1385
ucaaggaaga uggcau                                                       16


<210> 1386
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1386
gaagauggca uuucu                                                        15


<210> 1387
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1387
ucaaggaaga uggcauuucu a                                                 21


<210> 1388
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1388
ucaaggaaga uggcauuuc                                                    19


<210> 1389
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1389
ucaaggaaga uggcauuu                                                     18


<210> 1390
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1390
ucaaggaaga uggcauu                                                      17


<210> 1391
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1391
ucaaggaaga uggca                                                        15


<210> 1392
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1392
ucaaggaaga uggc                                                         14


<210> 1393
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1393
ucaaggaaga ugg                                                          13


<210> 1394
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1394
ucaaggaaga ug                                                           12


<210> 1395
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1395
ucaaggaaga u                                                            11


<210> 1396
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1396
ucaaggaaga                                                              10


<210> 1397
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1397
ucaaggaag                                                                9


<210> 1398
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1398
caaggaagau ggcauuucua g                                                 21


<210> 1399
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1399
caaggaagau ggcauuucua                                                   20


<210> 1400
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1400
caaggaagau ggcauuucu                                                    19


<210> 1401
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1401
caaggaagau ggcauuuc                                                     18


<210> 1402
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1402
caaggaagau ggcauuu                                                      17


<210> 1403
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1403
caaggaagau ggcauu                                                       16


<210> 1404
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1404
caaggaagau ggcau                                                        15


<210> 1405
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1405
caaggaagau ggca                                                         14


<210> 1406
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1406
caaggaagau ggc                                                          13


<210> 1407
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1407
caaggaagau gg                                                           12


<210> 1408
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1408
caaggaagau g                                                            11


<210> 1409
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1409
caaggaagau                                                              10


<210> 1410
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1410
caaggaaga                                                                9


<210> 1411
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1411
caaggaag                                                                 8


<210> 1412
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1412
aaggaagaug gcauuucuag                                                   20


<210> 1413
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1413
aaggaagaug gcauuucua                                                    19


<210> 1414
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1414
aaggaagaug gcauuucu                                                     18


<210> 1415
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1415
aaggaagaug gcauuuc                                                      17


<210> 1416
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1416
aaggaagaug gcauuu                                                       16


<210> 1417
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1417
aaggaagaug gcauu                                                        15


<210> 1418
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1418
aaggaagaug gcau                                                         14


<210> 1419
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1419
aaggaagaug gca                                                          13


<210> 1420
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1420
aaggaagaug gc                                                           12


<210> 1421
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1421
aaggaagaug g                                                            11


<210> 1422
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1422
aaggaagaug                                                              10


<210> 1423
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1423
aaggaagau                                                                9


<210> 1424
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1424
aaggaaga                                                                 8


<210> 1425
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1425
aggaagaugg cauuucuag                                                    19


<210> 1426
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1426
aggaagaugg cauuucua                                                     18


<210> 1427
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1427
aggaagaugg cauuucu                                                      17


<210> 1428
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1428
aggaagaugg cauuuc                                                       16


<210> 1429
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1429
aggaagaugg cauuu                                                        15


<210> 1430
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1430
aggaagaugg cauu                                                         14


<210> 1431
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1431
aggaagaugg cau                                                          13


<210> 1432
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1432
aggaagaugg ca                                                           12


<210> 1433
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1433
aggaagaugg                                                              10


<210> 1434
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1434
aggaagaug                                                                9


<210> 1435
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1435
aggaagau                                                                 8


<210> 1436
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1436
ggaagauggc auuucuag                                                     18


<210> 1437
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1437
ggaagauggc auuucua                                                      17


<210> 1438
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1438
ggaagauggc auuucu                                                       16


<210> 1439
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1439
ggaagauggc auuuc                                                        15


<210> 1440
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1440
ggaagauggc auuu                                                         14


<210> 1441
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1441
ggaagauggc auu                                                          13


<210> 1442
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1442
ggaagauggc au                                                           12


<210> 1443
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1443
ggaagauggc a                                                            11


<210> 1444
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1444
ggaagauggc                                                              10


<210> 1445
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1445
ggaagaug                                                                 8


<210> 1446
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1446
gaagauggca uuucuag                                                      17


<210> 1447
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1447
gaagauggca uuucua                                                       16


<210> 1448
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1448
gaagauggca uuuc                                                         14


<210> 1449
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1449
gaagauggca uuu                                                          13


<210> 1450
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1450
gaagauggca uu                                                           12


<210> 1451
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1451
gaagauggca u                                                            11


<210> 1452
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1452
gaagauggca                                                              10


<210> 1453
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1453
gaagauggc                                                                9


<210> 1454
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1454
gaagaugg                                                                 8


<210> 1455
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1455
aagauggcau uucuag                                                       16


<210> 1456
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1456
aagauggcau uucua                                                        15


<210> 1457
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1457
aagauggcau uucu                                                         14


<210> 1458
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1458
aagauggcau uuc                                                          13


<210> 1459
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1459
aagauggcau uu                                                           12


<210> 1460
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1460
aagauggcau u                                                            11


<210> 1461
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1461
aagauggcau                                                              10


<210> 1462
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1462
aagauggca                                                                9


<210> 1463
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1463
aagauggc                                                                 8


<210> 1464
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1464
agauggcauu ucuag                                                        15


<210> 1465
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1465
agauggcauu ucua                                                         14


<210> 1466
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1466
agauggcauu ucu                                                          13


<210> 1467
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1467
agauggcauu uc                                                           12


<210> 1468
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1468
agauggcauu u                                                            11


<210> 1469
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1469
agauggcauu                                                              10


<210> 1470
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1470
agauggcau                                                                9


<210> 1471
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1471
agauggca                                                                 8


<210> 1472
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1472
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 1473
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1473
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 1474
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1474
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 1475
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1475
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 1476
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1476
cuccaacauc aaggaagaug gcauuu                                            26


<210> 1477
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1477
cuccaacauc aaggaagaug gcauu                                             25


<210> 1478
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1478
cuccaacauc aaggaagaug gcau                                              24


<210> 1479
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1479
cuccaacauc aaggaagaug gca                                               23


<210> 1480
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1480
cuccaacauc aaggaagaug gc                                                22


<210> 1481
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1481
cuccaacauc aaggaagaug g                                                 21


<210> 1482
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1482
cuccaacauc aaggaagaug                                                   20


<210> 1483
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1483
cuccaacauc aaggaagau                                                    19


<210> 1484
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1484
cuccaacauc aaggaaga                                                     18


<210> 1485
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1485
cuccaacauc aaggaag                                                      17


<210> 1486
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1486
uccaacauca aggaagaugg cauuucuag                                         29


<210> 1487
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1487
uccaacauca aggaagaugg cauuucua                                          28


<210> 1488
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1488
uccaacauca aggaagaugg cauuucu                                           27


<210> 1489
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1489
uccaacauca aggaagaugg cauuuc                                            26


<210> 1490
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1490
uccaacauca aggaagaugg cauuu                                             25


<210> 1491
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1491
uccaacauca aggaagaugg cauu                                              24


<210> 1492
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1492
uccaacauca aggaagaugg cau                                               23


<210> 1493
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1493
uccaacauca aggaagaugg ca                                                22


<210> 1494
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1494
uccaacauca aggaagaugg c                                                 21


<210> 1495
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1495
uccaacauca aggaagaugg                                                   20


<210> 1496
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1496
uccaacauca aggaagaug                                                    19


<210> 1497
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1497
uccaacauca aggaagau                                                     18


<210> 1498
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1498
uccaacauca aggaaga                                                      17


<210> 1499
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1499
uccaacauca aggaag                                                       16


<210> 1500
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1500
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 1501
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1501
ccaacaucaa ggaagauggc auuucua                                           27


<210> 1502
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1502
ccaacaucaa ggaagauggc auuucu                                            26


<210> 1503
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1503
ccaacaucaa ggaagauggc auuuc                                             25


<210> 1504
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1504
ccaacaucaa ggaagauggc auuu                                              24


<210> 1505
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1505
ccaacaucaa ggaagauggc auu                                               23


<210> 1506
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1506
ccaacaucaa ggaagauggc au                                                22


<210> 1507
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1507
ccaacaucaa ggaagauggc a                                                 21


<210> 1508
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1508
ccaacaucaa ggaagauggc                                                   20


<210> 1509
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1509
ccaacaucaa ggaagaugg                                                    19


<210> 1510
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1510
ccaacaucaa ggaagaug                                                     18


<210> 1511
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1511
ccaacaucaa ggaagau                                                      17


<210> 1512
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1512
ccaacaucaa ggaaga                                                       16


<210> 1513
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1513
ccaacaucaa ggaag                                                        15


<210> 1514
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1514
caacaucaag gaagauggca uuucuag                                           27


<210> 1515
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1515
caacaucaag gaagauggca uuucua                                            26


<210> 1516
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1516
caacaucaag gaagauggca uuucu                                             25


<210> 1517
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1517
caacaucaag gaagauggca uuuc                                              24


<210> 1518
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1518
caacaucaag gaagauggca uuu                                               23


<210> 1519
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1519
caacaucaag gaagauggca uu                                                22


<210> 1520
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1520
caacaucaag gaagauggca u                                                 21


<210> 1521
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1521
caacaucaag gaagauggca                                                   20


<210> 1522
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1522
caacaucaag gaagauggc                                                    19


<210> 1523
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1523
caacaucaag gaagaugg                                                     18


<210> 1524
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1524
caacaucaag gaagaug                                                      17


<210> 1525
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1525
caacaucaag gaagau                                                       16


<210> 1526
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1526
caacaucaag gaaga                                                        15


<210> 1527
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1527
caacaucaag gaag                                                         14


<210> 1528
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1528
aacaucaagg aagauggcau uucuag                                            26


<210> 1529
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1529
aacaucaagg aagauggcau uucua                                             25


<210> 1530
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1530
aacaucaagg aagauggcau uucu                                              24


<210> 1531
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1531
aacaucaagg aagauggcau uuc                                               23


<210> 1532
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1532
aacaucaagg aagauggcau uu                                                22


<210> 1533
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1533
aacaucaagg aagauggcau u                                                 21


<210> 1534
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1534
aacaucaagg aagauggcau                                                   20


<210> 1535
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1535
aacaucaagg aagauggca                                                    19


<210> 1536
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1536
aacaucaagg aagauggc                                                     18


<210> 1537
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1537
aacaucaagg aagaugg                                                      17


<210> 1538
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1538
aacaucaagg aagaug                                                       16


<210> 1539
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1539
aacaucaagg aagau                                                        15


<210> 1540
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1540
aacaucaagg aaga                                                         14


<210> 1541
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1541
aacaucaagg aag                                                          13


<210> 1542
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1542
acaucaagga agauggcauu ucuag                                             25


<210> 1543
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1543
acaucaagga agauggcauu ucua                                              24


<210> 1544
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1544
acaucaagga agauggcauu ucu                                               23


<210> 1545
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1545
acaucaagga agauggcauu uc                                                22


<210> 1546
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1546
acaucaagga agauggcauu u                                                 21


<210> 1547
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1547
acaucaagga agauggcauu                                                   20


<210> 1548
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1548
acaucaagga agauggcau                                                    19


<210> 1549
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1549
acaucaagga agauggca                                                     18


<210> 1550
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1550
acaucaagga agauggc                                                      17


<210> 1551
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1551
acaucaagga agaugg                                                       16


<210> 1552
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1552
acaucaagga agaug                                                        15


<210> 1553
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1553
acaucaagga agau                                                         14


<210> 1554
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1554
acaucaagga aga                                                          13


<210> 1555
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1555
acaucaagga ag                                                           12


<210> 1556
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1556
caucaaggaa gauggcauuu cuag                                              24


<210> 1557
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1557
caucaaggaa gauggcauuu cua                                               23


<210> 1558
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1558
caucaaggaa gauggcauuu cu                                                22


<210> 1559
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1559
caucaaggaa gauggcauuu c                                                 21


<210> 1560
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1560
caucaaggaa gauggcauuu                                                   20


<210> 1561
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1561
caucaaggaa gauggcauu                                                    19


<210> 1562
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1562
caucaaggaa gauggcau                                                     18


<210> 1563
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1563
caucaaggaa gauggca                                                      17


<210> 1564
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1564
caucaaggaa gauggc                                                       16


<210> 1565
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1565
caucaaggaa gaugg                                                        15


<210> 1566
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1566
caucaaggaa gaug                                                         14


<210> 1567
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1567
caucaaggaa gau                                                          13


<210> 1568
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1568
caucaaggaa ga                                                           12


<210> 1569
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1569
caucaaggaa g                                                            11


<210> 1570
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1570
aucaaggaag auggcauuuc uag                                               23


<210> 1571
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1571
aucaaggaag auggcauuuc ua                                                22


<210> 1572
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1572
aucaaggaag auggcauuuc u                                                 21


<210> 1573
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1573
aucaaggaag auggcauuuc                                                   20


<210> 1574
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1574
aucaaggaag auggcauuu                                                    19


<210> 1575
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1575
aucaaggaag auggcauu                                                     18


<210> 1576
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1576
aucaaggaag auggcau                                                      17


<210> 1577
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1577
aucaaggaag auggca                                                       16


<210> 1578
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1578
aucaaggaag auggc                                                        15


<210> 1579
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1579
aucaaggaag augg                                                         14


<210> 1580
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1580
aucaaggaag aug                                                          13


<210> 1581
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1581
aucaaggaag au                                                           12


<210> 1582
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1582
aucaaggaag a                                                            11


<210> 1583
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1583
aucaaggaag                                                              10


<210> 1584
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1584
ccagagcagg uaccuccaac auc                                               23


<210> 1585
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1585
ccagagcagg uaccucca                                                     18


<210> 1586
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1586
ccucugugau uuuauaacuu gau                                               23


<210> 1587
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1587
ucacccacca ucacccu                                                      17


<210> 1588
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1588
ugauauccuc aaggucaccc                                                   20


<210> 1589
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1589
cugcuugaug aucaucucgu ug                                                22


<210> 1590
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1590
cugcuugaug aucaucuc                                                     18


<210> 1591
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1591
guuuccuuag uaaccacag                                                    19


<210> 1592
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 1592
guuuccuuag uaaccac                                                      17


<210> 1593
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1593
ucaaggaaga uggcauuucu                                                   20


<210> 1594
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1594
ucaaggaaga uggcauuucu ag                                                22


<210> 1595
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1595
gguaaguucu guccaagc                                                     18


<210> 1596
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1596
guaaguucug uccaagcc                                                     18


<210> 1597
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1597
agucgguaag uucugucc                                                     18


<210> 1598
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1598
cuguccaagc ccgguuga                                                     18


<210> 1599
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1599
uaaguucugu ccaag                                                        15


<210> 1600
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1600
uucuguccaa gcccgguuga                                                   20


<210> 1601
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1601
uucuguccaa gcccgguug                                                    19


<210> 1602
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1602
uucuguccaa gcccgguu                                                     18


<210> 1603
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1603
uucuguccaa gcccggu                                                      17


<210> 1604
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1604
uucuguccaa gcccgg                                                       16


<210> 1605
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1605
uucuguccaa gcccg                                                        15


<210> 1606
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1606
uucuguccaa gccc                                                         14


<210> 1607
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1607
uucuguccaa gcc                                                          13


<210> 1608
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1608
uucuguccaa gc                                                           12


<210> 1609
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1609
uucuguccaa g                                                            11


<210> 1610
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1610
uucuguccaa                                                              10


<210> 1611
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1611
uucugucca                                                                9


<210> 1612
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1612
uucugucc                                                                 8


<210> 1613
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1613
ucuguccaag cccgguuga                                                    19


<210> 1614
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1614
ucuguccaag cccgguug                                                     18


<210> 1615
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1615
ucuguccaag cccgguu                                                      17


<210> 1616
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1616
ucuguccaag cccggu                                                       16


<210> 1617
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1617
ucuguccaag cccgg                                                        15


<210> 1618
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1618
ucuguccaag cccg                                                         14


<210> 1619
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1619
ucuguccaag ccc                                                          13


<210> 1620
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1620
ucuguccaag cc                                                           12


<210> 1621
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1621
ucuguccaag c                                                            11


<210> 1622
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1622
ucuguccaag                                                              10


<210> 1623
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1623
ucuguccaa                                                                9


<210> 1624
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1624
ucugucca                                                                 8


<210> 1625
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1625
cuguccaagc ccgguug                                                      17


<210> 1626
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1626
cuguccaagc ccgguu                                                       16


<210> 1627
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1627
cuguccaagc ccggu                                                        15


<210> 1628
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1628
cuguccaagc ccgg                                                         14


<210> 1629
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1629
cuguccaagc ccg                                                          13


<210> 1630
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1630
cuguccaagc cc                                                           12


<210> 1631
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1631
cuguccaagc c                                                            11


<210> 1632
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1632
cuguccaagc                                                              10


<210> 1633
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 1633
cuguccaag                                                                9


<210> 1634
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 1634
cuguccaa                                                                 8


<210> 1635
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1635
guucugucca agcccgguug                                                   20


<210> 1636
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1636
guucugucca agcccgguu                                                    19


<210> 1637
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1637
guucugucca agcccggu                                                     18


<210> 1638
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1638
guucugucca agcccgg                                                      17


<210> 1639
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1639
guucugucca agcccg                                                       16


<210> 1640
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1640
guucugucca agccc                                                        15


<210> 1641
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1641
guucugucca agcc                                                         14


<210> 1642
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1642
guucugucca agc                                                          13


<210> 1643
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1643
guucugucca ag                                                           12


<210> 1644
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1644
guucugucca a                                                            11


<210> 1645
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1645
guucugucca                                                              10


<210> 1646
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1646
guucugucc                                                                9


<210> 1647
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1647
guucuguc                                                                 8


<210> 1648
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1648
aguucugucc aagcccgguu                                                   20


<210> 1649
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1649
aguucugucc aagcccggu                                                    19


<210> 1650
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1650
aguucugucc aagcccgg                                                     18


<210> 1651
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1651
aguucugucc aagcccg                                                      17


<210> 1652
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1652
aguucugucc aagccc                                                       16


<210> 1653
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1653
aguucugucc aagcc                                                        15


<210> 1654
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1654
aguucugucc aagc                                                         14


<210> 1655
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1655
aguucugucc aag                                                          13


<210> 1656
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1656
aguucugucc aa                                                           12


<210> 1657
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1657
aguucugucc a                                                            11


<210> 1658
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1658
aguucugucc                                                              10


<210> 1659
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1659
aguucuguc                                                                9


<210> 1660
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 1660
aguucugu                                                                 8


<210> 1661
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1661
aaguucuguc caagcccggu                                                   20


<210> 1662
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1662
aaguucuguc caagcccgg                                                    19


<210> 1663
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1663
aaguucuguc caagcccg                                                     18


<210> 1664
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1664
aaguucuguc caagccc                                                      17


<210> 1665
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1665
aaguucuguc caagcc                                                       16


<210> 1666
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1666
aaguucuguc caagc                                                        15


<210> 1667
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1667
aaguucuguc caag                                                         14


<210> 1668
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1668
aaguucuguc caa                                                          13


<210> 1669
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1669
aaguucuguc ca                                                           12


<210> 1670
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1670
aaguucuguc c                                                            11


<210> 1671
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1671
aaguucuguc                                                              10


<210> 1672
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 1672
aaguucugu                                                                9


<210> 1673
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 1673
aaguucug                                                                 8


<210> 1674
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1674
uaaguucugu ccaagcccgg                                                   20


<210> 1675
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1675
uaaguucugu ccaagcccg                                                    19


<210> 1676
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1676
uaaguucugu ccaagccc                                                     18


<210> 1677
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1677
uaaguucugu ccaagcc                                                      17


<210> 1678
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1678
uaaguucugu ccaagc                                                       16


<210> 1679
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1679
uaaguucugu ccaa                                                         14


<210> 1680
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1680
uaaguucugu cca                                                          13


<210> 1681
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1681
uaaguucugu cc                                                           12


<210> 1682
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1682
uaaguucugu c                                                            11


<210> 1683
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1683
uaaguucugu                                                              10


<210> 1684
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1684
uaaguucug                                                                9


<210> 1685
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1685
uaaguucu                                                                 8


<210> 1686
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1686
guaaguucug uccaagcccg                                                   20


<210> 1687
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1687
guaaguucug uccaagccc                                                    19


<210> 1688
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1688
guaaguucug uccaagc                                                      17


<210> 1689
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1689
guaaguucug uccaag                                                       16


<210> 1690
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1690
guaaguucug uccaa                                                        15


<210> 1691
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1691
guaaguucug ucca                                                         14


<210> 1692
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1692
guaaguucug ucc                                                          13


<210> 1693
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1693
guaaguucug uc                                                           12


<210> 1694
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1694
guaaguucug u                                                            11


<210> 1695
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1695
guaaguucug                                                              10


<210> 1696
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1696
guaaguucu                                                                9


<210> 1697
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1697
guaaguuc                                                                 8


<210> 1698
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1698
gguaaguucu guccaagccc                                                   20


<210> 1699
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1699
gguaaguucu guccaagcc                                                    19


<210> 1700
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1700
gguaaguucu guccaag                                                      17


<210> 1701
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1701
gguaaguucu guccaa                                                       16


<210> 1702
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1702
gguaaguucu gucca                                                        15


<210> 1703
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1703
gguaaguucu gucc                                                         14


<210> 1704
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1704
gguaaguucu guc                                                          13


<210> 1705
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1705
gguaaguucu gu                                                           12


<210> 1706
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1706
gguaaguucu g                                                            11


<210> 1707
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1707
gguaaguucu                                                              10


<210> 1708
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1708
gguaaguuc                                                                9


<210> 1709
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"

<400> 1709
gguaaguu                                                                 8


<210> 1710
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1710
cgguaaguuc uguccaagcc                                                   20


<210> 1711
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1711
cgguaaguuc uguccaagc                                                    19


<210> 1712
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1712
cgguaaguuc uguccaag                                                     18


<210> 1713
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1713
cgguaaguuc uguccaa                                                      17


<210> 1714
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1714
cgguaaguuc ugucca                                                       16


<210> 1715
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1715
cgguaaguuc ugucc                                                        15


<210> 1716
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1716
cgguaaguuc uguc                                                         14


<210> 1717
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1717
cgguaaguuc ugu                                                          13


<210> 1718
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1718
cgguaaguuc ug                                                           12


<210> 1719
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1719
cgguaaguuc u                                                            11


<210> 1720
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1720
cgguaaguuc                                                              10


<210> 1721
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 1721
cgguaaguu                                                                9


<210> 1722
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 1722
cgguaagu                                                                 8


<210> 1723
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1723
ucgguaaguu cuguccaagc                                                   20


<210> 1724
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1724
ucgguaaguu cuguccaag                                                    19


<210> 1725
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1725
ucgguaaguu cuguccaa                                                     18


<210> 1726
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1726
ucgguaaguu cugucca                                                      17


<210> 1727
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1727
ucgguaaguu cugucc                                                       16


<210> 1728
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1728
ucgguaaguu cuguc                                                        15


<210> 1729
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1729
ucgguaaguu cugu                                                         14


<210> 1730
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1730
ucgguaaguu cug                                                          13


<210> 1731
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1731
ucgguaaguu cu                                                           12


<210> 1732
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1732
ucgguaaguu c                                                            11


<210> 1733
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 1733
ucgguaaguu                                                              10


<210> 1734
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 1734
ucgguaagu                                                                9


<210> 1735
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1735
gucgguaagu ucuguccaag                                                   20


<210> 1736
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1736
gucgguaagu ucuguccaa                                                    19


<210> 1737
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1737
gucgguaagu ucugucca                                                     18


<210> 1738
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1738
gucgguaagu ucugucc                                                      17


<210> 1739
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1739
gucgguaagu ucuguc                                                       16


<210> 1740
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1740
gucgguaagu ucugu                                                        15


<210> 1741
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1741
gucgguaagu ucug                                                         14


<210> 1742
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1742
gucgguaagu ucu                                                          13


<210> 1743
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1743
gucgguaagu uc                                                           12


<210> 1744
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 1744
gucgguaagu u                                                            11


<210> 1745
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 1745
gucgguaagu                                                              10


<210> 1746
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1746
agucgguaag uucuguccaa                                                   20


<210> 1747
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1747
agucgguaag uucugucca                                                    19


<210> 1748
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1748
agucgguaag uucuguc                                                      17


<210> 1749
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1749
agucgguaag uucugu                                                       16


<210> 1750
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1750
agucgguaag uucug                                                        15


<210> 1751
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1751
agucgguaag uucu                                                         14


<210> 1752
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1752
agucgguaag uuc                                                          13


<210> 1753
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 1753
agucgguaag uu                                                           12


<210> 1754
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 1754
agucgguaag u                                                            11


<210> 1755
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1755
cagucgguaa guucugucca                                                   20


<210> 1756
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1756
cagucgguaa guucugucc                                                    19


<210> 1757
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1757
cagucgguaa guucuguc                                                     18


<210> 1758
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1758
cagucgguaa guucugu                                                      17


<210> 1759
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1759
cagucgguaa guucug                                                       16


<210> 1760
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1760
cagucgguaa guucu                                                        15


<210> 1761
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1761
cagucgguaa guuc                                                         14


<210> 1762
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 1762
cagucgguaa guu                                                          13


<210> 1763
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 1763
cagucgguaa gu                                                           12


<210> 1764
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1764
ccagucggua aguucugucc                                                   20


<210> 1765
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1765
ccagucggua aguucuguc                                                    19


<210> 1766
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1766
ccagucggua aguucugu                                                     18


<210> 1767
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1767
ccagucggua aguucug                                                      17


<210> 1768
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1768
ccagucggua aguucu                                                       16


<210> 1769
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1769
ccagucggua aguuc                                                        15


<210> 1770
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 1770
ccagucggua aguu                                                         14


<210> 1771
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 1771
ccagucggua agu                                                          13


<210> 1772
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1772
gccagucggu aaguucuguc                                                   20


<210> 1773
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1773
gccagucggu aaguucugu                                                    19


<210> 1774
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1774
gccagucggu aaguucug                                                     18


<210> 1775
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1775
gccagucggu aaguucu                                                      17


<210> 1776
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1776
gccagucggu aaguuc                                                       16


<210> 1777
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1777
gccagucggu aaguu                                                        15


<210> 1778
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1778
gccagucggu aagu                                                         14


<210> 1779
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1779
ucaaggaaga uggcauuucu                                                   20


<210> 1780
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1780
ucaaggaaga uggcauuucu ag                                                22


<210> 1781
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1781
ucaaggaaga uggcau                                                       16


<210> 1782
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1782
gaagauggca uuucu                                                        15


<210> 1783
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1783
ucaaggaaga uggcauuucu a                                                 21


<210> 1784
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1784
ucaaggaaga uggcauuuc                                                    19


<210> 1785
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1785
ucaaggaaga uggcauuu                                                     18


<210> 1786
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1786
ucaaggaaga uggcauu                                                      17


<210> 1787
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1787
ucaaggaaga uggca                                                        15


<210> 1788
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1788
ucaaggaaga uggc                                                         14


<210> 1789
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 1789
ucaaggaaga ugg                                                          13


<210> 1790
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 1790
ucaaggaaga ug                                                           12


<210> 1791
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 1791
ucaaggaaga u                                                            11


<210> 1792
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 1792
ucaaggaaga                                                              10


<210> 1793
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 1793
ucaaggaag                                                                9


<210> 1794
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1794
caaggaagau ggcauuucua g                                                 21


<210> 1795
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1795
caaggaagau ggcauuucua                                                   20


<210> 1796
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1796
caaggaagau ggcauuucu                                                    19


<210> 1797
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1797
caaggaagau ggcauuuc                                                     18


<210> 1798
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1798
caaggaagau ggcauuu                                                      17


<210> 1799
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1799
caaggaagau ggcauu                                                       16


<210> 1800
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1800
caaggaagau ggcau                                                        15


<210> 1801
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1801
caaggaagau ggca                                                         14


<210> 1802
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1802
caaggaagau ggc                                                          13


<210> 1803
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 1803
caaggaagau gg                                                           12


<210> 1804
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 1804
caaggaagau g                                                            11


<210> 1805
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 1805
caaggaagau                                                              10


<210> 1806
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 1806
caaggaaga                                                                9


<210> 1807
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 1807
caaggaag                                                                 8


<210> 1808
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1808
aaggaagaug gcauuucuag                                                   20


<210> 1809
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1809
aaggaagaug gcauuucua                                                    19


<210> 1810
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1810
aaggaagaug gcauuucu                                                     18


<210> 1811
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1811
aaggaagaug gcauuuc                                                      17


<210> 1812
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1812
aaggaagaug gcauuu                                                       16


<210> 1813
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1813
aaggaagaug gcauu                                                        15


<210> 1814
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1814
aaggaagaug gcau                                                         14


<210> 1815
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1815
aaggaagaug gca                                                          13


<210> 1816
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1816
aaggaagaug gc                                                           12


<210> 1817
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"

<400> 1817
aaggaagaug g                                                            11


<210> 1818
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"

<400> 1818
aaggaagaug                                                              10


<210> 1819
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"

<400> 1819
aaggaagau                                                                9


<210> 1820
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"

<400> 1820
aaggaaga                                                                 8


<210> 1821
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1821
aggaagaugg cauuucuag                                                    19


<210> 1822
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1822
aggaagaugg cauuucua                                                     18


<210> 1823
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1823
aggaagaugg cauuucu                                                      17


<210> 1824
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1824
aggaagaugg cauuuc                                                       16


<210> 1825
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1825
aggaagaugg cauuu                                                        15


<210> 1826
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1826
aggaagaugg cauu                                                         14


<210> 1827
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1827
aggaagaugg cau                                                          13


<210> 1828
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 1828
aggaagaugg ca                                                           12


<210> 1829
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"

<400> 1829
aggaagaugg                                                              10


<210> 1830
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"

<400> 1830
aggaagaug                                                                9


<210> 1831
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"

<400> 1831
aggaagau                                                                 8


<210> 1832
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1832
ggaagauggc auuucuag                                                     18


<210> 1833
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1833
ggaagauggc auuucua                                                      17


<210> 1834
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1834
ggaagauggc auuucu                                                       16


<210> 1835
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1835
ggaagauggc auuuc                                                        15


<210> 1836
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1836
ggaagauggc auuu                                                         14


<210> 1837
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1837
ggaagauggc auu                                                          13


<210> 1838
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1838
ggaagauggc au                                                           12


<210> 1839
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1839
ggaagauggc a                                                            11


<210> 1840
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1840
ggaagauggc                                                              10


<210> 1841
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"

<400> 1841
ggaagaug                                                                 8


<210> 1842
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1842
gaagauggca uuucuag                                                      17


<210> 1843
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1843
gaagauggca uuucua                                                       16


<210> 1844
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1844
gaagauggca uuuc                                                         14


<210> 1845
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1845
gaagauggca uuu                                                          13


<210> 1846
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1846
gaagauggca uu                                                           12


<210> 1847
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1847
gaagauggca u                                                            11


<210> 1848
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1848
gaagauggca                                                              10


<210> 1849
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1849
gaagauggc                                                                9


<210> 1850
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"

<400> 1850
gaagaugg                                                                 8


<210> 1851
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1851
aagauggcau uucuag                                                       16


<210> 1852
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1852
aagauggcau uucua                                                        15


<210> 1853
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1853
aagauggcau uucu                                                         14


<210> 1854
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 1854
aagauggcau uuc                                                          13


<210> 1855
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1855
aagauggcau uu                                                           12


<210> 1856
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1856
aagauggcau u                                                            11


<210> 1857
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1857
aagauggcau                                                              10


<210> 1858
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1858
aagauggca                                                                9


<210> 1859
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1859
aagauggc                                                                 8


<210> 1860
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1860
agauggcauu ucuag                                                        15


<210> 1861
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1861
agauggcauu ucua                                                         14


<210> 1862
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1862
agauggcauu ucu                                                          13


<210> 1863
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1863
agauggcauu uc                                                           12


<210> 1864
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1864
agauggcauu u                                                            11


<210> 1865
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1865
agauggcauu                                                              10


<210> 1866
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1866
agauggcau                                                                9


<210> 1867
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1867
agauggca                                                                 8


<210> 1868
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 1868
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 1869
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 1869
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 1870
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 1870
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 1871
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 1871
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 1872
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 1872
cuccaacauc aaggaagaug gcauuu                                            26


<210> 1873
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 1873
cuccaacauc aaggaagaug gcauu                                             25


<210> 1874
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 1874
cuccaacauc aaggaagaug gcau                                              24


<210> 1875
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 1875
cuccaacauc aaggaagaug gca                                               23


<210> 1876
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 1876
cuccaacauc aaggaagaug gc                                                22


<210> 1877
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1877
cuccaacauc aaggaagaug g                                                 21


<210> 1878
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1878
cuccaacauc aaggaagaug                                                   20


<210> 1879
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1879
cuccaacauc aaggaagau                                                    19


<210> 1880
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1880
cuccaacauc aaggaaga                                                     18


<210> 1881
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 1881
cuccaacauc aaggaag                                                      17


<210> 1882
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 1882
uccaacauca aggaagaugg cauuucuag                                         29


<210> 1883
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 1883
uccaacauca aggaagaugg cauuucua                                          28


<210> 1884
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 1884
uccaacauca aggaagaugg cauuucu                                           27


<210> 1885
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 1885
uccaacauca aggaagaugg cauuuc                                            26


<210> 1886
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 1886
uccaacauca aggaagaugg cauuu                                             25


<210> 1887
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 1887
uccaacauca aggaagaugg cauu                                              24


<210> 1888
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 1888
uccaacauca aggaagaugg cau                                               23


<210> 1889
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 1889
uccaacauca aggaagaugg ca                                                22


<210> 1890
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 1890
uccaacauca aggaagaugg c                                                 21


<210> 1891
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1891
uccaacauca aggaagaugg                                                   20


<210> 1892
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1892
uccaacauca aggaagaug                                                    19


<210> 1893
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1893
uccaacauca aggaagau                                                     18


<210> 1894
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1894
uccaacauca aggaaga                                                      17


<210> 1895
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 1895
uccaacauca aggaag                                                       16


<210> 1896
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 1896
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 1897
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 1897
ccaacaucaa ggaagauggc auuucua                                           27


<210> 1898
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 1898
ccaacaucaa ggaagauggc auuucu                                            26


<210> 1899
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 1899
ccaacaucaa ggaagauggc auuuc                                             25


<210> 1900
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1900
ccaacaucaa ggaagauggc auuu                                              24


<210> 1901
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1901
ccaacaucaa ggaagauggc auu                                               23


<210> 1902
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1902
ccaacaucaa ggaagauggc au                                                22


<210> 1903
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1903
ccaacaucaa ggaagauggc a                                                 21


<210> 1904
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1904
ccaacaucaa ggaagauggc                                                   20


<210> 1905
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1905
ccaacaucaa ggaagaugg                                                    19


<210> 1906
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1906
ccaacaucaa ggaagaug                                                     18


<210> 1907
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1907
ccaacaucaa ggaagau                                                      17


<210> 1908
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1908
ccaacaucaa ggaaga                                                       16


<210> 1909
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 1909
ccaacaucaa ggaag                                                        15


<210> 1910
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 1910
caacaucaag gaagauggca uuucuag                                           27


<210> 1911
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 1911
caacaucaag gaagauggca uuucua                                            26


<210> 1912
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 1912
caacaucaag gaagauggca uuucu                                             25


<210> 1913
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 1913
caacaucaag gaagauggca uuuc                                              24


<210> 1914
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1914
caacaucaag gaagauggca uuu                                               23


<210> 1915
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1915
caacaucaag gaagauggca uu                                                22


<210> 1916
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1916
caacaucaag gaagauggca u                                                 21


<210> 1917
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1917
caacaucaag gaagauggca                                                   20


<210> 1918
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1918
caacaucaag gaagauggc                                                    19


<210> 1919
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1919
caacaucaag gaagaugg                                                     18


<210> 1920
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1920
caacaucaag gaagaug                                                      17


<210> 1921
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1921
caacaucaag gaagau                                                       16


<210> 1922
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1922
caacaucaag gaaga                                                        15


<210> 1923
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 1923
caacaucaag gaag                                                         14


<210> 1924
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 1924
aacaucaagg aagauggcau uucuag                                            26


<210> 1925
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 1925
aacaucaagg aagauggcau uucua                                             25


<210> 1926
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 1926
aacaucaagg aagauggcau uucu                                              24


<210> 1927
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 1927
aacaucaagg aagauggcau uuc                                               23


<210> 1928
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1928
aacaucaagg aagauggcau uu                                                22


<210> 1929
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1929
aacaucaagg aagauggcau u                                                 21


<210> 1930
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1930
aacaucaagg aagauggcau                                                   20


<210> 1931
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1931
aacaucaagg aagauggca                                                    19


<210> 1932
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1932
aacaucaagg aagauggc                                                     18


<210> 1933
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 1933
aacaucaagg aagaugg                                                      17


<210> 1934
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 1934
aacaucaagg aagaug                                                       16


<210> 1935
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 1935
aacaucaagg aagau                                                        15


<210> 1936
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 1936
aacaucaagg aaga                                                         14


<210> 1937
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 1937
aacaucaagg aag                                                          13


<210> 1938
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 1938
acaucaagga agauggcauu ucuag                                             25


<210> 1939
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 1939
acaucaagga agauggcauu ucua                                              24


<210> 1940
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 1940
acaucaagga agauggcauu ucu                                               23


<210> 1941
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 1941
acaucaagga agauggcauu uc                                                22


<210> 1942
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1942
acaucaagga agauggcauu u                                                 21


<210> 1943
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1943
acaucaagga agauggcauu                                                   20


<210> 1944
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1944
acaucaagga agauggcau                                                    19


<210> 1945
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1945
acaucaagga agauggca                                                     18


<210> 1946
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1946
acaucaagga agauggc                                                      17


<210> 1947
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 1947
acaucaagga agaugg                                                       16


<210> 1948
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 1948
acaucaagga agaug                                                        15


<210> 1949
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 1949
acaucaagga agau                                                         14


<210> 1950
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 1950
acaucaagga aga                                                          13


<210> 1951
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 1951
acaucaagga ag                                                           12


<210> 1952
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 1952
caucaaggaa gauggcauuu cuag                                              24


<210> 1953
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 1953
caucaaggaa gauggcauuu cua                                               23


<210> 1954
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 1954
caucaaggaa gauggcauuu cu                                                22


<210> 1955
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 1955
caucaaggaa gauggcauuu c                                                 21


<210> 1956
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1956
caucaaggaa gauggcauuu                                                   20


<210> 1957
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1957
caucaaggaa gauggcauu                                                    19


<210> 1958
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1958
caucaaggaa gauggcau                                                     18


<210> 1959
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1959
caucaaggaa gauggca                                                      17


<210> 1960
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1960
caucaaggaa gauggc                                                       16


<210> 1961
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 1961
caucaaggaa gaugg                                                        15


<210> 1962
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 1962
caucaaggaa gaug                                                         14


<210> 1963
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 1963
caucaaggaa gau                                                          13


<210> 1964
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 1964
caucaaggaa ga                                                           12


<210> 1965
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 1965
caucaaggaa g                                                            11


<210> 1966
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1966
aucaaggaag auggcauuuc uag                                               23


<210> 1967
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1967
aucaaggaag auggcauuuc ua                                                22


<210> 1968
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1968
aucaaggaag auggcauuuc u                                                 21


<210> 1969
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1969
aucaaggaag auggcauuuc                                                   20


<210> 1970
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1970
aucaaggaag auggcauuu                                                    19


<210> 1971
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1971
aucaaggaag auggcauu                                                     18


<210> 1972
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1972
aucaaggaag auggcau                                                      17


<210> 1973
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1973
aucaaggaag auggca                                                       16


<210> 1974
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 1974
aucaaggaag auggc                                                        15


<210> 1975
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 1975
aucaaggaag augg                                                         14


<210> 1976
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 1976
aucaaggaag aug                                                          13


<210> 1977
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 1977
aucaaggaag au                                                           12


<210> 1978
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 1978
aucaaggaag a                                                            11


<210> 1979
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 1979
aucaaggaag                                                              10


<210> 1980
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 1980
ccagagcagg uaccuccaac auc                                               23


<210> 1981
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1981
ccagagcagg uaccucca                                                     18


<210> 1982
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1982
ccucugugau uuuauaacuu gau                                               23


<210> 1983
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 1983
ucacccacca ucacccu                                                      17


<210> 1984
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 1984
ugauauccuc aaggucaccc                                                   20


<210> 1985
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1985
cugcuugaug aucaucucgu ug                                                22


<210> 1986
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1986
cugcuugaug aucaucuc                                                     18


<210> 1987
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1987
guuuccuuag uaaccacag                                                    19


<210> 1988
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 1988
guuuccuuag uaaccac                                                      17


<210> 1989
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1989
ucaaggaaga uggcauuucu                                                   20


<210> 1990
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 1990
ucaaggaaga uggcauuucu ag                                                22


<210> 1991
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1991
gguaaguucu guccaagc                                                     18


<210> 1992
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1992
guaaguucug uccaagcc                                                     18


<210> 1993
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 1993
agucgguaag uucugucc                                                     18


<210> 1994
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1994
cuguccaagc ccgguuga                                                     18


<210> 1995
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 1995
uaaguucugu ccaag                                                        15


<210> 1996
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1996
uucuguccaa gcccgguuga                                                   20


<210> 1997
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1997
uucuguccaa gcccgguug                                                    19


<210> 1998
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1998
uucuguccaa gcccgguu                                                     18


<210> 1999
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 1999
uucuguccaa gcccggu                                                      17


<210> 2000
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2000
uucuguccaa gcccgg                                                       16


<210> 2001
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2001
uucuguccaa gcccg                                                        15


<210> 2002
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2002
uucuguccaa gccc                                                         14


<210> 2003
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2003
uucuguccaa gcc                                                          13


<210> 2004
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2004
uucuguccaa gc                                                           12


<210> 2005
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2005
uucuguccaa g                                                            11


<210> 2006
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2006
uucuguccaa                                                              10


<210> 2007
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2007
uucugucca                                                                9


<210> 2008
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2008
uucugucc                                                                 8


<210> 2009
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2009
ucuguccaag cccgguuga                                                    19


<210> 2010
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2010
ucuguccaag cccgguug                                                     18


<210> 2011
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2011
ucuguccaag cccgguu                                                      17


<210> 2012
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2012
ucuguccaag cccggu                                                       16


<210> 2013
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2013
ucuguccaag cccgg                                                        15


<210> 2014
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2014
ucuguccaag cccg                                                         14


<210> 2015
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2015
ucuguccaag ccc                                                          13


<210> 2016
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2016
ucuguccaag cc                                                           12


<210> 2017
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2017
ucuguccaag c                                                            11


<210> 2018
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2018
ucuguccaag                                                              10


<210> 2019
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2019
ucuguccaa                                                                9


<210> 2020
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2020
ucugucca                                                                 8


<210> 2021
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2021
cuguccaagc ccgguug                                                      17


<210> 2022
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2022
cuguccaagc ccgguu                                                       16


<210> 2023
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2023
cuguccaagc ccggu                                                        15


<210> 2024
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2024
cuguccaagc ccgg                                                         14


<210> 2025
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2025
cuguccaagc ccg                                                          13


<210> 2026
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2026
cuguccaagc cc                                                           12


<210> 2027
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2027
cuguccaagc c                                                            11


<210> 2028
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2028
cuguccaagc                                                              10


<210> 2029
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 2029
cuguccaag                                                                9


<210> 2030
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 2030
cuguccaa                                                                 8


<210> 2031
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2031
guucugucca agcccgguug                                                   20


<210> 2032
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2032
guucugucca agcccgguu                                                    19


<210> 2033
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2033
guucugucca agcccggu                                                     18


<210> 2034
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2034
guucugucca agcccgg                                                      17


<210> 2035
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2035
guucugucca agcccg                                                       16


<210> 2036
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2036
guucugucca agccc                                                        15


<210> 2037
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2037
guucugucca agcc                                                         14


<210> 2038
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2038
guucugucca agc                                                          13


<210> 2039
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2039
guucugucca ag                                                           12


<210> 2040
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2040
guucugucca a                                                            11


<210> 2041
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2041
guucugucca                                                              10


<210> 2042
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2042
guucugucc                                                                9


<210> 2043
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2043
guucuguc                                                                 8


<210> 2044
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2044
aguucugucc aagcccgguu                                                   20


<210> 2045
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2045
aguucugucc aagcccggu                                                    19


<210> 2046
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2046
aguucugucc aagcccgg                                                     18


<210> 2047
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2047
aguucugucc aagcccg                                                      17


<210> 2048
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2048
aguucugucc aagccc                                                       16


<210> 2049
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2049
aguucugucc aagcc                                                        15


<210> 2050
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2050
aguucugucc aagc                                                         14


<210> 2051
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2051
aguucugucc aag                                                          13


<210> 2052
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2052
aguucugucc aa                                                           12


<210> 2053
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2053
aguucugucc a                                                            11


<210> 2054
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2054
aguucugucc                                                              10


<210> 2055
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2055
aguucuguc                                                                9


<210> 2056
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 2056
aguucugu                                                                 8


<210> 2057
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2057
aaguucuguc caagcccggu                                                   20


<210> 2058
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2058
aaguucuguc caagcccgg                                                    19


<210> 2059
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2059
aaguucuguc caagcccg                                                     18


<210> 2060
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2060
aaguucuguc caagccc                                                      17


<210> 2061
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2061
aaguucuguc caagcc                                                       16


<210> 2062
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2062
aaguucuguc caagc                                                        15


<210> 2063
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2063
aaguucuguc caag                                                         14


<210> 2064
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2064
aaguucuguc caa                                                          13


<210> 2065
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2065
aaguucuguc ca                                                           12


<210> 2066
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2066
aaguucuguc c                                                            11


<210> 2067
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2067
aaguucuguc                                                              10


<210> 2068
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 2068
aaguucugu                                                                9


<210> 2069
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 2069
aaguucug                                                                 8


<210> 2070
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2070
uaaguucugu ccaagcccgg                                                   20


<210> 2071
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2071
uaaguucugu ccaagcccg                                                    19


<210> 2072
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2072
uaaguucugu ccaagccc                                                     18


<210> 2073
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2073
uaaguucugu ccaagcc                                                      17


<210> 2074
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2074
uaaguucugu ccaagc                                                       16


<210> 2075
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2075
uaaguucugu ccaa                                                         14


<210> 2076
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2076
uaaguucugu cca                                                          13


<210> 2077
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2077
uaaguucugu cc                                                           12


<210> 2078
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2078
uaaguucugu c                                                            11


<210> 2079
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2079
uaaguucugu                                                              10


<210> 2080
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2080
uaaguucug                                                                9


<210> 2081
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2081
uaaguucu                                                                 8


<210> 2082
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2082
guaaguucug uccaagcccg                                                   20


<210> 2083
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2083
guaaguucug uccaagccc                                                    19


<210> 2084
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2084
guaaguucug uccaagc                                                      17


<210> 2085
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2085
guaaguucug uccaag                                                       16


<210> 2086
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2086
guaaguucug uccaa                                                        15


<210> 2087
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2087
guaaguucug ucca                                                         14


<210> 2088
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2088
guaaguucug ucc                                                          13


<210> 2089
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2089
guaaguucug uc                                                           12


<210> 2090
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2090
guaaguucug u                                                            11


<210> 2091
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2091
guaaguucug                                                              10


<210> 2092
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2092
guaaguucu                                                                9


<210> 2093
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2093
guaaguuc                                                                 8


<210> 2094
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2094
gguaaguucu guccaagccc                                                   20


<210> 2095
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2095
gguaaguucu guccaagcc                                                    19


<210> 2096
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2096
gguaaguucu guccaag                                                      17


<210> 2097
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2097
gguaaguucu guccaa                                                       16


<210> 2098
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2098
gguaaguucu gucca                                                        15


<210> 2099
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2099
gguaaguucu gucc                                                         14


<210> 2100
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2100
gguaaguucu guc                                                          13


<210> 2101
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2101
gguaaguucu gu                                                           12


<210> 2102
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2102
gguaaguucu g                                                            11


<210> 2103
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2103
gguaaguucu                                                              10


<210> 2104
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2104
gguaaguuc                                                                9


<210> 2105
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 2105
gguaaguu                                                                 8


<210> 2106
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2106
cgguaaguuc uguccaagcc                                                   20


<210> 2107
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2107
cgguaaguuc uguccaagc                                                    19


<210> 2108
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2108
cgguaaguuc uguccaag                                                     18


<210> 2109
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2109
cgguaaguuc uguccaa                                                      17


<210> 2110
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2110
cgguaaguuc ugucca                                                       16


<210> 2111
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2111
cgguaaguuc ugucc                                                        15


<210> 2112
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2112
cgguaaguuc uguc                                                         14


<210> 2113
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2113
cgguaaguuc ugu                                                          13


<210> 2114
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2114
cgguaaguuc ug                                                           12


<210> 2115
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2115
cgguaaguuc u                                                            11


<210> 2116
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2116
cgguaaguuc                                                              10


<210> 2117
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 2117
cgguaaguu                                                                9


<210> 2118
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 2118
cgguaagu                                                                 8


<210> 2119
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2119
ucgguaaguu cuguccaagc                                                   20


<210> 2120
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2120
ucgguaaguu cuguccaag                                                    19


<210> 2121
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2121
ucgguaaguu cuguccaa                                                     18


<210> 2122
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2122
ucgguaaguu cugucca                                                      17


<210> 2123
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2123
ucgguaaguu cugucc                                                       16


<210> 2124
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2124
ucgguaaguu cuguc                                                        15


<210> 2125
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2125
ucgguaaguu cugu                                                         14


<210> 2126
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2126
ucgguaaguu cug                                                          13


<210> 2127
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2127
ucgguaaguu cu                                                           12


<210> 2128
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2128
ucgguaaguu c                                                            11


<210> 2129
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 2129
ucgguaaguu                                                              10


<210> 2130
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 2130
ucgguaagu                                                                9


<210> 2131
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2131
gucgguaagu ucuguccaag                                                   20


<210> 2132
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2132
gucgguaagu ucuguccaa                                                    19


<210> 2133
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2133
gucgguaagu ucugucca                                                     18


<210> 2134
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2134
gucgguaagu ucugucc                                                      17


<210> 2135
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2135
gucgguaagu ucuguc                                                       16


<210> 2136
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2136
gucgguaagu ucugu                                                        15


<210> 2137
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2137
gucgguaagu ucug                                                         14


<210> 2138
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2138
gucgguaagu ucu                                                          13


<210> 2139
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2139
gucgguaagu uc                                                           12


<210> 2140
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 2140
gucgguaagu u                                                            11


<210> 2141
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 2141
gucgguaagu                                                              10


<210> 2142
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2142
agucgguaag uucuguccaa                                                   20


<210> 2143
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2143
agucgguaag uucugucca                                                    19


<210> 2144
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2144
agucgguaag uucuguc                                                      17


<210> 2145
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2145
agucgguaag uucugu                                                       16


<210> 2146
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2146
agucgguaag uucug                                                        15


<210> 2147
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2147
agucgguaag uucu                                                         14


<210> 2148
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2148
agucgguaag uuc                                                          13


<210> 2149
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 2149
agucgguaag uu                                                           12


<210> 2150
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 2150
agucgguaag u                                                            11


<210> 2151
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2151
cagucgguaa guucugucca                                                   20


<210> 2152
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2152
cagucgguaa guucugucc                                                    19


<210> 2153
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2153
cagucgguaa guucuguc                                                     18


<210> 2154
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2154
cagucgguaa guucugu                                                      17


<210> 2155
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2155
cagucgguaa guucug                                                       16


<210> 2156
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2156
cagucgguaa guucu                                                        15


<210> 2157
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2157
cagucgguaa guuc                                                         14


<210> 2158
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 2158
cagucgguaa guu                                                          13


<210> 2159
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 2159
cagucgguaa gu                                                           12


<210> 2160
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2160
ccagucggua aguucugucc                                                   20


<210> 2161
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2161
ccagucggua aguucuguc                                                    19


<210> 2162
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2162
ccagucggua aguucugu                                                     18


<210> 2163
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2163
ccagucggua aguucug                                                      17


<210> 2164
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2164
ccagucggua aguucu                                                       16


<210> 2165
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2165
ccagucggua aguuc                                                        15


<210> 2166
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 2166
ccagucggua aguu                                                         14


<210> 2167
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 2167
ccagucggua agu                                                          13


<210> 2168
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2168
gccagucggu aaguucuguc                                                   20


<210> 2169
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2169
gccagucggu aaguucugu                                                    19


<210> 2170
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2170
gccagucggu aaguucug                                                     18


<210> 2171
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2171
gccagucggu aaguucu                                                      17


<210> 2172
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2172
gccagucggu aaguuc                                                       16


<210> 2173
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2173
gccagucggu aaguu                                                        15


<210> 2174
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2174
gccagucggu aagu                                                         14


<210> 2175
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2175
ucaaggaaga uggcauuucu                                                   20


<210> 2176
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2176
ucaaggaaga uggcauuucu ag                                                22


<210> 2177
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2177
ucaaggaaga uggcau                                                       16


<210> 2178
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2178
gaagauggca uuucu                                                        15


<210> 2179
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2179
ucaaggaaga uggcauuucu a                                                 21


<210> 2180
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2180
ucaaggaaga uggcauuuc                                                    19


<210> 2181
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2181
ucaaggaaga uggcauuu                                                     18


<210> 2182
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2182
ucaaggaaga uggcauu                                                      17


<210> 2183
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2183
ucaaggaaga uggca                                                        15


<210> 2184
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2184
ucaaggaaga uggc                                                         14


<210> 2185
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 2185
ucaaggaaga ugg                                                          13


<210> 2186
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 2186
ucaaggaaga ug                                                           12


<210> 2187
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 2187
ucaaggaaga u                                                            11


<210> 2188
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 2188
ucaaggaaga                                                              10


<210> 2189
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 2189
ucaaggaag                                                                9


<210> 2190
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2190
caaggaagau ggcauuucua g                                                 21


<210> 2191
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2191
caaggaagau ggcauuucua                                                   20


<210> 2192
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2192
caaggaagau ggcauuucu                                                    19


<210> 2193
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2193
caaggaagau ggcauuuc                                                     18


<210> 2194
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2194
caaggaagau ggcauuu                                                      17


<210> 2195
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2195
caaggaagau ggcauu                                                       16


<210> 2196
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2196
caaggaagau ggcau                                                        15


<210> 2197
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2197
caaggaagau ggca                                                         14


<210> 2198
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2198
caaggaagau ggc                                                          13


<210> 2199
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 2199
caaggaagau gg                                                           12


<210> 2200
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 2200
caaggaagau g                                                            11


<210> 2201
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 2201
caaggaagau                                                              10


<210> 2202
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 2202
caaggaaga                                                                9


<210> 2203
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<400> 2203
caaggaag                                                                 8


<210> 2204
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2204
aaggaagaug gcauuucuag                                                   20


<210> 2205
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2205
aaggaagaug gcauuucua                                                    19


<210> 2206
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2206
aaggaagaug gcauuucu                                                     18


<210> 2207
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2207
aaggaagaug gcauuuc                                                      17


<210> 2208
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2208
aaggaagaug gcauuu                                                       16


<210> 2209
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2209
aaggaagaug gcauu                                                        15


<210> 2210
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2210
aaggaagaug gcau                                                         14


<210> 2211
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2211
aaggaagaug gca                                                          13


<210> 2212
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2212
aaggaagaug gc                                                           12


<210> 2213
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 2213
aaggaagaug g                                                            11


<210> 2214
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 2214
aaggaagaug                                                              10


<210> 2215
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 2215
aaggaagau                                                                9


<210> 2216
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 2216
aaggaaga                                                                 8


<210> 2217
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2217
aggaagaugg cauuucuag                                                    19


<210> 2218
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2218
aggaagaugg cauuucua                                                     18


<210> 2219
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2219
aggaagaugg cauuucu                                                      17


<210> 2220
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2220
aggaagaugg cauuuc                                                       16


<210> 2221
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2221
aggaagaugg cauuu                                                        15


<210> 2222
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2222
aggaagaugg cauu                                                         14


<210> 2223
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2223
aggaagaugg cau                                                          13


<210> 2224
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 2224
aggaagaugg ca                                                           12


<210> 2225
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 2225
aggaagaugg                                                              10


<210> 2226
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 2226
aggaagaug                                                                9


<210> 2227
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 2227
aggaagau                                                                 8


<210> 2228
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2228
ggaagauggc auuucuag                                                     18


<210> 2229
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2229
ggaagauggc auuucua                                                      17


<210> 2230
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2230
ggaagauggc auuucu                                                       16


<210> 2231
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2231
ggaagauggc auuuc                                                        15


<210> 2232
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2232
ggaagauggc auuu                                                         14


<210> 2233
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2233
ggaagauggc auu                                                          13


<210> 2234
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2234
ggaagauggc au                                                           12


<210> 2235
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2235
ggaagauggc a                                                            11


<210> 2236
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2236
ggaagauggc                                                              10


<210> 2237
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 2237
ggaagaug                                                                 8


<210> 2238
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2238
gaagauggca uuucuag                                                      17


<210> 2239
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2239
gaagauggca uuucua                                                       16


<210> 2240
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 2240
gaagauggca uuuc                                                         14


<210> 2241
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2241
gaagauggca uuu                                                          13


<210> 2242
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2242
gaagauggca uu                                                           12


<210> 2243
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2243
gaagauggca u                                                            11


<210> 2244
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2244
gaagauggca                                                              10


<210> 2245
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2245
gaagauggc                                                                9


<210> 2246
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<400> 2246
gaagaugg                                                                 8


<210> 2247
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2247
aagauggcau uucuag                                                       16


<210> 2248
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2248
aagauggcau uucua                                                        15


<210> 2249
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2249
aagauggcau uucu                                                         14


<210> 2250
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 2250
aagauggcau uuc                                                          13


<210> 2251
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2251
aagauggcau uu                                                           12


<210> 2252
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2252
aagauggcau u                                                            11


<210> 2253
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2253
aagauggcau                                                              10


<210> 2254
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2254
aagauggca                                                                9


<210> 2255
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2255
aagauggc                                                                 8


<210> 2256
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2256
agauggcauu ucuag                                                        15


<210> 2257
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2257
agauggcauu ucua                                                         14


<210> 2258
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2258
agauggcauu ucu                                                          13


<210> 2259
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 2259
agauggcauu uc                                                           12


<210> 2260
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2260
agauggcauu u                                                            11


<210> 2261
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2261
agauggcauu                                                              10


<210> 2262
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2262
agauggcau                                                                9


<210> 2263
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2263
agauggca                                                                 8


<210> 2264
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 2264
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 2265
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 2265
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 2266
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 2266
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 2267
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 2267
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 2268
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 2268
cuccaacauc aaggaagaug gcauuu                                            26


<210> 2269
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 2269
cuccaacauc aaggaagaug gcauu                                             25


<210> 2270
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 2270
cuccaacauc aaggaagaug gcau                                              24


<210> 2271
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 2271
cuccaacauc aaggaagaug gca                                               23


<210> 2272
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 2272
cuccaacauc aaggaagaug gc                                                22


<210> 2273
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2273
cuccaacauc aaggaagaug g                                                 21


<210> 2274
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2274
cuccaacauc aaggaagaug                                                   20


<210> 2275
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2275
cuccaacauc aaggaagau                                                    19


<210> 2276
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2276
cuccaacauc aaggaaga                                                     18


<210> 2277
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 2277
cuccaacauc aaggaag                                                      17


<210> 2278
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 2278
uccaacauca aggaagaugg cauuucuag                                         29


<210> 2279
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 2279
uccaacauca aggaagaugg cauuucua                                          28


<210> 2280
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 2280
uccaacauca aggaagaugg cauuucu                                           27


<210> 2281
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 2281
uccaacauca aggaagaugg cauuuc                                            26


<210> 2282
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 2282
uccaacauca aggaagaugg cauuu                                             25


<210> 2283
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 2283
uccaacauca aggaagaugg cauu                                              24


<210> 2284
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 2284
uccaacauca aggaagaugg cau                                               23


<210> 2285
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 2285
uccaacauca aggaagaugg ca                                                22


<210> 2286
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 2286
uccaacauca aggaagaugg c                                                 21


<210> 2287
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2287
uccaacauca aggaagaugg                                                   20


<210> 2288
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2288
uccaacauca aggaagaug                                                    19


<210> 2289
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2289
uccaacauca aggaagau                                                     18


<210> 2290
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2290
uccaacauca aggaaga                                                      17


<210> 2291
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 2291
uccaacauca aggaag                                                       16


<210> 2292
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 2292
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 2293
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 2293
ccaacaucaa ggaagauggc auuucua                                           27


<210> 2294
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 2294
ccaacaucaa ggaagauggc auuucu                                            26


<210> 2295
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 2295
ccaacaucaa ggaagauggc auuuc                                             25


<210> 2296
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2296
ccaacaucaa ggaagauggc auuu                                              24


<210> 2297
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2297
ccaacaucaa ggaagauggc auu                                               23


<210> 2298
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2298
ccaacaucaa ggaagauggc au                                                22


<210> 2299
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2299
ccaacaucaa ggaagauggc a                                                 21


<210> 2300
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2300
ccaacaucaa ggaagauggc                                                   20


<210> 2301
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2301
ccaacaucaa ggaagaugg                                                    19


<210> 2302
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2302
ccaacaucaa ggaagaug                                                     18


<210> 2303
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2303
ccaacaucaa ggaagau                                                      17


<210> 2304
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2304
ccaacaucaa ggaaga                                                       16


<210> 2305
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 2305
ccaacaucaa ggaag                                                        15


<210> 2306
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 2306
caacaucaag gaagauggca uuucuag                                           27


<210> 2307
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 2307
caacaucaag gaagauggca uuucua                                            26


<210> 2308
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 2308
caacaucaag gaagauggca uuucu                                             25


<210> 2309
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 2309
caacaucaag gaagauggca uuuc                                              24


<210> 2310
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2310
caacaucaag gaagauggca uuu                                               23


<210> 2311
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2311
caacaucaag gaagauggca uu                                                22


<210> 2312
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2312
caacaucaag gaagauggca u                                                 21


<210> 2313
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2313
caacaucaag gaagauggca                                                   20


<210> 2314
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 2314
caacaucaag gaagauggc                                                    19


<210> 2315
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2315
caacaucaag gaagaugg                                                     18


<210> 2316
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2316
caacaucaag gaagaug                                                      17


<210> 2317
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2317
caacaucaag gaagau                                                       16


<210> 2318
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2318
caacaucaag gaaga                                                        15


<210> 2319
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 2319
caacaucaag gaag                                                         14


<210> 2320
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 2320
aacaucaagg aagauggcau uucuag                                            26


<210> 2321
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 2321
aacaucaagg aagauggcau uucua                                             25


<210> 2322
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 2322
aacaucaagg aagauggcau uucu                                              24


<210> 2323
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 2323
aacaucaagg aagauggcau uuc                                               23


<210> 2324
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2324
aacaucaagg aagauggcau uu                                                22


<210> 2325
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2325
aacaucaagg aagauggcau u                                                 21


<210> 2326
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2326
aacaucaagg aagauggcau                                                   20


<210> 2327
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2327
aacaucaagg aagauggca                                                    19


<210> 2328
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2328
aacaucaagg aagauggc                                                     18


<210> 2329
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 2329
aacaucaagg aagaugg                                                      17


<210> 2330
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 2330
aacaucaagg aagaug                                                       16


<210> 2331
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 2331
aacaucaagg aagau                                                        15


<210> 2332
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 2332
aacaucaagg aaga                                                         14


<210> 2333
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 2333
aacaucaagg aag                                                          13


<210> 2334
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 2334
acaucaagga agauggcauu ucuag                                             25


<210> 2335
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 2335
acaucaagga agauggcauu ucua                                              24


<210> 2336
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 2336
acaucaagga agauggcauu ucu                                               23


<210> 2337
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 2337
acaucaagga agauggcauu uc                                                22


<210> 2338
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2338
acaucaagga agauggcauu u                                                 21


<210> 2339
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2339
acaucaagga agauggcauu                                                   20


<210> 2340
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2340
acaucaagga agauggcau                                                    19


<210> 2341
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2341
acaucaagga agauggca                                                     18


<210> 2342
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2342
acaucaagga agauggc                                                      17


<210> 2343
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 2343
acaucaagga agaugg                                                       16


<210> 2344
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 2344
acaucaagga agaug                                                        15


<210> 2345
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 2345
acaucaagga agau                                                         14


<210> 2346
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 2346
acaucaagga aga                                                          13


<210> 2347
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 2347
acaucaagga ag                                                           12


<210> 2348
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 2348
caucaaggaa gauggcauuu cuag                                              24


<210> 2349
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 2349
caucaaggaa gauggcauuu cua                                               23


<210> 2350
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 2350
caucaaggaa gauggcauuu cu                                                22


<210> 2351
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 2351
caucaaggaa gauggcauuu c                                                 21


<210> 2352
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2352
caucaaggaa gauggcauuu                                                   20


<210> 2353
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2353
caucaaggaa gauggcauu                                                    19


<210> 2354
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2354
caucaaggaa gauggcau                                                     18


<210> 2355
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2355
caucaaggaa gauggca                                                      17


<210> 2356
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2356
caucaaggaa gauggc                                                       16


<210> 2357
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 2357
caucaaggaa gaugg                                                        15


<210> 2358
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 2358
caucaaggaa gaug                                                         14


<210> 2359
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 2359
caucaaggaa gau                                                          13


<210> 2360
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 2360
caucaaggaa ga                                                           12


<210> 2361
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 2361
caucaaggaa g                                                            11


<210> 2362
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2362
aucaaggaag auggcauuuc uag                                               23


<210> 2363
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2363
aucaaggaag auggcauuuc ua                                                22


<210> 2364
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2364
aucaaggaag auggcauuuc u                                                 21


<210> 2365
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2365
aucaaggaag auggcauuuc                                                   20


<210> 2366
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2366
aucaaggaag auggcauuu                                                    19


<210> 2367
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2367
aucaaggaag auggcauu                                                     18


<210> 2368
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2368
aucaaggaag auggcau                                                      17


<210> 2369
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2369
aucaaggaag auggca                                                       16


<210> 2370
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 2370
aucaaggaag auggc                                                        15


<210> 2371
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 2371
aucaaggaag augg                                                         14


<210> 2372
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 2372
aucaaggaag aug                                                          13


<210> 2373
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 2373
aucaaggaag au                                                           12


<210> 2374
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 2374
aucaaggaag a                                                            11


<210> 2375
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 2375
aucaaggaag                                                              10


<210> 2376
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 2376
ccagagcagg uaccuccaac auc                                               23


<210> 2377
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2377
ccagagcagg uaccucca                                                     18


<210> 2378
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2378
ccucugugau uuuauaacuu gau                                               23


<210> 2379
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 2379
ucacccacca ucacccu                                                      17


<210> 2380
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 2380
ugauauccuc aaggucaccc                                                   20


<210> 2381
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2381
cugcuugaug aucaucucgu ug                                                22


<210> 2382
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 2382
cugcuugaug aucaucuc                                                     18


<210> 2383
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2383
guuuccuuag uaaccacag                                                    19


<210> 2384
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 2384
guuuccuuag uaaccac                                                      17


<210> 2385
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2385
ucaaggaaga uggcauuucu                                                   20


<210> 2386
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2386
ucaaggaaga uggcauuucu ag                                                22


<210> 2387
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2387
gguaaguucu guccaagc                                                     18


<210> 2388
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2388
guaaguucug uccaagcc                                                     18


<210> 2389
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2389
agucgguaag uucugucc                                                     18


<210> 2390
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2390
cuguccaagc ccgguuga                                                     18


<210> 2391
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2391
uaaguucugu ccaag                                                        15


<210> 2392
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2392
uucuguccaa gcccgguuga                                                   20


<210> 2393
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2393
uucuguccaa gcccgguug                                                    19


<210> 2394
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2394
uucuguccaa gcccgguu                                                     18


<210> 2395
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2395
uucuguccaa gcccggu                                                      17


<210> 2396
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2396
uucuguccaa gcccgg                                                       16


<210> 2397
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2397
uucuguccaa gcccg                                                        15


<210> 2398
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2398
uucuguccaa gccc                                                         14


<210> 2399
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2399
uucuguccaa gcc                                                          13


<210> 2400
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2400
uucuguccaa gc                                                           12


<210> 2401
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2401
uucuguccaa g                                                            11


<210> 2402
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2402
uucuguccaa                                                              10


<210> 2403
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2403
uucugucca                                                                9


<210> 2404
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2404
uucugucc                                                                 8


<210> 2405
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2405
ucuguccaag cccgguuga                                                    19


<210> 2406
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2406
ucuguccaag cccgguug                                                     18


<210> 2407
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2407
ucuguccaag cccgguu                                                      17


<210> 2408
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2408
ucuguccaag cccggu                                                       16


<210> 2409
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2409
ucuguccaag cccgg                                                        15


<210> 2410
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2410
ucuguccaag cccg                                                         14


<210> 2411
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2411
ucuguccaag ccc                                                          13


<210> 2412
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2412
ucuguccaag cc                                                           12


<210> 2413
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2413
ucuguccaag c                                                            11


<210> 2414
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2414
ucuguccaag                                                              10


<210> 2415
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2415
ucuguccaa                                                                9


<210> 2416
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2416
ucugucca                                                                 8


<210> 2417
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2417
cuguccaagc ccgguug                                                      17


<210> 2418
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2418
cuguccaagc ccgguu                                                       16


<210> 2419
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2419
cuguccaagc ccggu                                                        15


<210> 2420
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2420
cuguccaagc ccgg                                                         14


<210> 2421
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2421
cuguccaagc ccg                                                          13


<210> 2422
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2422
cuguccaagc cc                                                           12


<210> 2423
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2423
cuguccaagc c                                                            11


<210> 2424
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2424
cuguccaagc                                                              10


<210> 2425
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2425
cuguccaag                                                                9


<210> 2426
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2426
cuguccaa                                                                 8


<210> 2427
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2427
guucugucca agcccgguug                                                   20


<210> 2428
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2428
guucugucca agcccgguu                                                    19


<210> 2429
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2429
guucugucca agcccggu                                                     18


<210> 2430
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2430
guucugucca agcccgg                                                      17


<210> 2431
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2431
guucugucca agcccg                                                       16


<210> 2432
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2432
guucugucca agccc                                                        15


<210> 2433
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2433
guucugucca agcc                                                         14


<210> 2434
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2434
guucugucca agc                                                          13


<210> 2435
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2435
guucugucca ag                                                           12


<210> 2436
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2436
guucugucca a                                                            11


<210> 2437
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2437
guucugucca                                                              10


<210> 2438
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2438
guucugucc                                                                9


<210> 2439
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2439
guucuguc                                                                 8


<210> 2440
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2440
aguucugucc aagcccgguu                                                   20


<210> 2441
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2441
aguucugucc aagcccggu                                                    19


<210> 2442
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2442
aguucugucc aagcccgg                                                     18


<210> 2443
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2443
aguucugucc aagcccg                                                      17


<210> 2444
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2444
aguucugucc aagccc                                                       16


<210> 2445
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2445
aguucugucc aagcc                                                        15


<210> 2446
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2446
aguucugucc aagc                                                         14


<210> 2447
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2447
aguucugucc aag                                                          13


<210> 2448
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2448
aguucugucc aa                                                           12


<210> 2449
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2449
aguucugucc a                                                            11


<210> 2450
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2450
aguucugucc                                                              10


<210> 2451
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2451
aguucuguc                                                                9


<210> 2452
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2452
aguucugu                                                                 8


<210> 2453
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2453
aaguucuguc caagcccggu                                                   20


<210> 2454
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2454
aaguucuguc caagcccgg                                                    19


<210> 2455
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2455
aaguucuguc caagcccg                                                     18


<210> 2456
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2456
aaguucuguc caagccc                                                      17


<210> 2457
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2457
aaguucuguc caagcc                                                       16


<210> 2458
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2458
aaguucuguc caagc                                                        15


<210> 2459
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2459
aaguucuguc caag                                                         14


<210> 2460
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2460
aaguucuguc caa                                                          13


<210> 2461
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2461
aaguucuguc ca                                                           12


<210> 2462
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2462
aaguucuguc c                                                            11


<210> 2463
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2463
aaguucuguc                                                              10


<210> 2464
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2464
aaguucugu                                                                9


<210> 2465
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2465
aaguucug                                                                 8


<210> 2466
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2466
uaaguucugu ccaagcccgg                                                   20


<210> 2467
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2467
uaaguucugu ccaagcccg                                                    19


<210> 2468
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2468
uaaguucugu ccaagccc                                                     18


<210> 2469
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2469
uaaguucugu ccaagcc                                                      17


<210> 2470
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2470
uaaguucugu ccaagc                                                       16


<210> 2471
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2471
uaaguucugu ccaa                                                         14


<210> 2472
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2472
uaaguucugu cca                                                          13


<210> 2473
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2473
uaaguucugu cc                                                           12


<210> 2474
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2474
uaaguucugu c                                                            11


<210> 2475
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2475
uaaguucugu                                                              10


<210> 2476
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2476
uaaguucug                                                                9


<210> 2477
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2477
uaaguucu                                                                 8


<210> 2478
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2478
guaaguucug uccaagcccg                                                   20


<210> 2479
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2479
guaaguucug uccaagccc                                                    19


<210> 2480
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2480
guaaguucug uccaagc                                                      17


<210> 2481
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2481
guaaguucug uccaag                                                       16


<210> 2482
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2482
guaaguucug uccaa                                                        15


<210> 2483
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2483
guaaguucug ucca                                                         14


<210> 2484
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2484
guaaguucug ucc                                                          13


<210> 2485
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2485
guaaguucug uc                                                           12


<210> 2486
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2486
guaaguucug u                                                            11


<210> 2487
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2487
guaaguucug                                                              10


<210> 2488
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2488
guaaguucu                                                                9


<210> 2489
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2489
guaaguuc                                                                 8


<210> 2490
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2490
gguaaguucu guccaagccc                                                   20


<210> 2491
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2491
gguaaguucu guccaagcc                                                    19


<210> 2492
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2492
gguaaguucu guccaag                                                      17


<210> 2493
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2493
gguaaguucu guccaa                                                       16


<210> 2494
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2494
gguaaguucu gucca                                                        15


<210> 2495
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2495
gguaaguucu gucc                                                         14


<210> 2496
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2496
gguaaguucu guc                                                          13


<210> 2497
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2497
gguaaguucu gu                                                           12


<210> 2498
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2498
gguaaguucu g                                                            11


<210> 2499
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2499
gguaaguucu                                                              10


<210> 2500
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2500
gguaaguuc                                                                9


<210> 2501
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2501
gguaaguu                                                                 8


<210> 2502
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2502
cgguaaguuc uguccaagcc                                                   20


<210> 2503
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2503
cgguaaguuc uguccaagc                                                    19


<210> 2504
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2504
cgguaaguuc uguccaag                                                     18


<210> 2505
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2505
cgguaaguuc uguccaa                                                      17


<210> 2506
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2506
cgguaaguuc ugucca                                                       16


<210> 2507
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2507
cgguaaguuc ugucc                                                        15


<210> 2508
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2508
cgguaaguuc uguc                                                         14


<210> 2509
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2509
cgguaaguuc ugu                                                          13


<210> 2510
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2510
cgguaaguuc ug                                                           12


<210> 2511
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2511
cgguaaguuc u                                                            11


<210> 2512
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2512
cgguaaguuc                                                              10


<210> 2513
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2513
cgguaaguu                                                                9


<210> 2514
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2514
cgguaagu                                                                 8


<210> 2515
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2515
ucgguaaguu cuguccaagc                                                   20


<210> 2516
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2516
ucgguaaguu cuguccaag                                                    19


<210> 2517
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2517
ucgguaaguu cuguccaa                                                     18


<210> 2518
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2518
ucgguaaguu cugucca                                                      17


<210> 2519
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2519
ucgguaaguu cugucc                                                       16


<210> 2520
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2520
ucgguaaguu cuguc                                                        15


<210> 2521
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2521
ucgguaaguu cugu                                                         14


<210> 2522
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2522
ucgguaaguu cug                                                          13


<210> 2523
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2523
ucgguaaguu cu                                                           12


<210> 2524
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2524
ucgguaaguu c                                                            11


<210> 2525
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2525
ucgguaaguu                                                              10


<210> 2526
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2526
ucgguaagu                                                                9


<210> 2527
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2527
gucgguaagu ucuguccaag                                                   20


<210> 2528
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2528
gucgguaagu ucuguccaa                                                    19


<210> 2529
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2529
gucgguaagu ucugucca                                                     18


<210> 2530
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2530
gucgguaagu ucugucc                                                      17


<210> 2531
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2531
gucgguaagu ucuguc                                                       16


<210> 2532
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2532
gucgguaagu ucugu                                                        15


<210> 2533
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2533
gucgguaagu ucug                                                         14


<210> 2534
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2534
gucgguaagu ucu                                                          13


<210> 2535
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2535
gucgguaagu uc                                                           12


<210> 2536
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2536
gucgguaagu u                                                            11


<210> 2537
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2537
gucgguaagu                                                              10


<210> 2538
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2538
agucgguaag uucuguccaa                                                   20


<210> 2539
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2539
agucgguaag uucugucca                                                    19


<210> 2540
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2540
agucgguaag uucuguc                                                      17


<210> 2541
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2541
agucgguaag uucugu                                                       16


<210> 2542
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2542
agucgguaag uucug                                                        15


<210> 2543
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2543
agucgguaag uucu                                                         14


<210> 2544
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2544
agucgguaag uuc                                                          13


<210> 2545
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2545
agucgguaag uu                                                           12


<210> 2546
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2546
agucgguaag u                                                            11


<210> 2547
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2547
cagucgguaa guucugucca                                                   20


<210> 2548
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2548
cagucgguaa guucugucc                                                    19


<210> 2549
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2549
cagucgguaa guucuguc                                                     18


<210> 2550
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2550
cagucgguaa guucugu                                                      17


<210> 2551
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2551
cagucgguaa guucug                                                       16


<210> 2552
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2552
cagucgguaa guucu                                                        15


<210> 2553
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2553
cagucgguaa guuc                                                         14


<210> 2554
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2554
cagucgguaa guu                                                          13


<210> 2555
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2555
cagucgguaa gu                                                           12


<210> 2556
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2556
ccagucggua aguucugucc                                                   20


<210> 2557
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2557
ccagucggua aguucuguc                                                    19


<210> 2558
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2558
ccagucggua aguucugu                                                     18


<210> 2559
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2559
ccagucggua aguucug                                                      17


<210> 2560
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2560
ccagucggua aguucu                                                       16


<210> 2561
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2561
ccagucggua aguuc                                                        15


<210> 2562
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2562
ccagucggua aguu                                                         14


<210> 2563
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2563
ccagucggua agu                                                          13


<210> 2564
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2564
gccagucggu aaguucuguc                                                   20


<210> 2565
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2565
gccagucggu aaguucugu                                                    19


<210> 2566
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2566
gccagucggu aaguucug                                                     18


<210> 2567
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2567
gccagucggu aaguucu                                                      17


<210> 2568
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2568
gccagucggu aaguuc                                                       16


<210> 2569
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2569
gccagucggu aaguu                                                        15


<210> 2570
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2570
gccagucggu aagu                                                         14


<210> 2571
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2571
ucaaggaaga uggcauuucu                                                   20


<210> 2572
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2572
ucaaggaaga uggcauuucu ag                                                22


<210> 2573
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2573
ucaaggaaga uggcau                                                       16


<210> 2574
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2574
gaagauggca uuucu                                                        15


<210> 2575
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2575
ucaaggaaga uggcauuucu a                                                 21


<210> 2576
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2576
ucaaggaaga uggcauuuc                                                    19


<210> 2577
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2577
ucaaggaaga uggcauuu                                                     18


<210> 2578
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2578
ucaaggaaga uggcauu                                                      17


<210> 2579
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2579
ucaaggaaga uggca                                                        15


<210> 2580
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2580
ucaaggaaga uggc                                                         14


<210> 2581
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2581
ucaaggaaga ugg                                                          13


<210> 2582
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2582
ucaaggaaga ug                                                           12


<210> 2583
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2583
ucaaggaaga u                                                            11


<210> 2584
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2584
ucaaggaaga                                                              10


<210> 2585
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2585
ucaaggaag                                                                9


<210> 2586
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2586
caaggaagau ggcauuucua g                                                 21


<210> 2587
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2587
caaggaagau ggcauuucua                                                   20


<210> 2588
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2588
caaggaagau ggcauuucu                                                    19


<210> 2589
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2589
caaggaagau ggcauuuc                                                     18


<210> 2590
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2590
caaggaagau ggcauuu                                                      17


<210> 2591
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2591
caaggaagau ggcauu                                                       16


<210> 2592
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2592
caaggaagau ggcau                                                        15


<210> 2593
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2593
caaggaagau ggca                                                         14


<210> 2594
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2594
caaggaagau ggc                                                          13


<210> 2595
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2595
caaggaagau gg                                                           12


<210> 2596
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2596
caaggaagau g                                                            11


<210> 2597
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2597
caaggaagau                                                              10


<210> 2598
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2598
caaggaaga                                                                9


<210> 2599
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2599
caaggaag                                                                 8


<210> 2600
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2600
aaggaagaug gcauuucuag                                                   20


<210> 2601
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2601
aaggaagaug gcauuucua                                                    19


<210> 2602
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2602
aaggaagaug gcauuucu                                                     18


<210> 2603
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2603
aaggaagaug gcauuuc                                                      17


<210> 2604
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2604
aaggaagaug gcauuu                                                       16


<210> 2605
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2605
aaggaagaug gcauu                                                        15


<210> 2606
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2606
aaggaagaug gcau                                                         14


<210> 2607
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2607
aaggaagaug gca                                                          13


<210> 2608
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2608
aaggaagaug gc                                                           12


<210> 2609
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2609
aaggaagaug g                                                            11


<210> 2610
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2610
aaggaagaug                                                              10


<210> 2611
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2611
aaggaagau                                                                9


<210> 2612
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2612
aaggaaga                                                                 8


<210> 2613
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2613
aggaagaugg cauuucuag                                                    19


<210> 2614
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2614
aggaagaugg cauuucua                                                     18


<210> 2615
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2615
aggaagaugg cauuucu                                                      17


<210> 2616
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2616
aggaagaugg cauuuc                                                       16


<210> 2617
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2617
aggaagaugg cauuu                                                        15


<210> 2618
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2618
aggaagaugg cauu                                                         14


<210> 2619
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2619
aggaagaugg cau                                                          13


<210> 2620
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2620
aggaagaugg ca                                                           12


<210> 2621
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2621
aggaagaugg                                                              10


<210> 2622
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2622
aggaagaug                                                                9


<210> 2623
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2623
aggaagau                                                                 8


<210> 2624
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2624
ggaagauggc auuucuag                                                     18


<210> 2625
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2625
ggaagauggc auuucua                                                      17


<210> 2626
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2626
ggaagauggc auuucu                                                       16


<210> 2627
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2627
ggaagauggc auuuc                                                        15


<210> 2628
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2628
ggaagauggc auuu                                                         14


<210> 2629
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2629
ggaagauggc auu                                                          13


<210> 2630
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2630
ggaagauggc au                                                           12


<210> 2631
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2631
ggaagauggc a                                                            11


<210> 2632
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2632
ggaagauggc                                                              10


<210> 2633
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2633
ggaagaug                                                                 8


<210> 2634
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2634
gaagauggca uuucuag                                                      17


<210> 2635
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2635
gaagauggca uuucua                                                       16


<210> 2636
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2636
gaagauggca uuuc                                                         14


<210> 2637
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2637
gaagauggca uuu                                                          13


<210> 2638
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2638
gaagauggca uu                                                           12


<210> 2639
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2639
gaagauggca u                                                            11


<210> 2640
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2640
gaagauggca                                                              10


<210> 2641
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2641
gaagauggc                                                                9


<210> 2642
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2642
gaagaugg                                                                 8


<210> 2643
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2643
aagauggcau uucuag                                                       16


<210> 2644
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2644
aagauggcau uucua                                                        15


<210> 2645
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2645
aagauggcau uucu                                                         14


<210> 2646
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2646
aagauggcau uuc                                                          13


<210> 2647
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2647
aagauggcau uu                                                           12


<210> 2648
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2648
aagauggcau u                                                            11


<210> 2649
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2649
aagauggcau                                                              10


<210> 2650
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2650
aagauggca                                                                9


<210> 2651
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2651
aagauggc                                                                 8


<210> 2652
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2652
agauggcauu ucuag                                                        15


<210> 2653
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2653
agauggcauu ucua                                                         14


<210> 2654
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2654
agauggcauu ucu                                                          13


<210> 2655
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2655
agauggcauu uc                                                           12


<210> 2656
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2656
agauggcauu u                                                            11


<210> 2657
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2657
agauggcauu                                                              10


<210> 2658
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2658
agauggcau                                                                9


<210> 2659
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2659
agauggca                                                                 8


<210> 2660
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2660
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 2661
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2661
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 2662
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2662
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 2663
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2663
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 2664
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2664
cuccaacauc aaggaagaug gcauuu                                            26


<210> 2665
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2665
cuccaacauc aaggaagaug gcauu                                             25


<210> 2666
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2666
cuccaacauc aaggaagaug gcau                                              24


<210> 2667
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2667
cuccaacauc aaggaagaug gca                                               23


<210> 2668
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2668
cuccaacauc aaggaagaug gc                                                22


<210> 2669
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2669
cuccaacauc aaggaagaug g                                                 21


<210> 2670
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2670
cuccaacauc aaggaagaug                                                   20


<210> 2671
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2671
cuccaacauc aaggaagau                                                    19


<210> 2672
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2672
cuccaacauc aaggaaga                                                     18


<210> 2673
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2673
cuccaacauc aaggaag                                                      17


<210> 2674
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2674
uccaacauca aggaagaugg cauuucuag                                         29


<210> 2675
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2675
uccaacauca aggaagaugg cauuucua                                          28


<210> 2676
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2676
uccaacauca aggaagaugg cauuucu                                           27


<210> 2677
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2677
uccaacauca aggaagaugg cauuuc                                            26


<210> 2678
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2678
uccaacauca aggaagaugg cauuu                                             25


<210> 2679
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2679
uccaacauca aggaagaugg cauu                                              24


<210> 2680
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2680
uccaacauca aggaagaugg cau                                               23


<210> 2681
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2681
uccaacauca aggaagaugg ca                                                22


<210> 2682
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2682
uccaacauca aggaagaugg c                                                 21


<210> 2683
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2683
uccaacauca aggaagaugg                                                   20


<210> 2684
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2684
uccaacauca aggaagaug                                                    19


<210> 2685
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2685
uccaacauca aggaagau                                                     18


<210> 2686
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2686
uccaacauca aggaaga                                                      17


<210> 2687
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2687
uccaacauca aggaag                                                       16


<210> 2688
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2688
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 2689
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2689
ccaacaucaa ggaagauggc auuucua                                           27


<210> 2690
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2690
ccaacaucaa ggaagauggc auuucu                                            26


<210> 2691
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2691
ccaacaucaa ggaagauggc auuuc                                             25


<210> 2692
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2692
ccaacaucaa ggaagauggc auuu                                              24


<210> 2693
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2693
ccaacaucaa ggaagauggc auu                                               23


<210> 2694
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2694
ccaacaucaa ggaagauggc au                                                22


<210> 2695
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2695
ccaacaucaa ggaagauggc a                                                 21


<210> 2696
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2696
ccaacaucaa ggaagauggc                                                   20


<210> 2697
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2697
ccaacaucaa ggaagaugg                                                    19


<210> 2698
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2698
ccaacaucaa ggaagaug                                                     18


<210> 2699
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2699
ccaacaucaa ggaagau                                                      17


<210> 2700
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2700
ccaacaucaa ggaaga                                                       16


<210> 2701
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2701
ccaacaucaa ggaag                                                        15


<210> 2702
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2702
caacaucaag gaagauggca uuucuag                                           27


<210> 2703
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2703
caacaucaag gaagauggca uuucua                                            26


<210> 2704
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2704
caacaucaag gaagauggca uuucu                                             25


<210> 2705
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2705
caacaucaag gaagauggca uuuc                                              24


<210> 2706
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2706
caacaucaag gaagauggca uuu                                               23


<210> 2707
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2707
caacaucaag gaagauggca uu                                                22


<210> 2708
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2708
caacaucaag gaagauggca u                                                 21


<210> 2709
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2709
caacaucaag gaagauggca                                                   20


<210> 2710
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2710
caacaucaag gaagauggc                                                    19


<210> 2711
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2711
caacaucaag gaagaugg                                                     18


<210> 2712
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2712
caacaucaag gaagaug                                                      17


<210> 2713
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2713
caacaucaag gaagau                                                       16


<210> 2714
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2714
caacaucaag gaaga                                                        15


<210> 2715
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2715
caacaucaag gaag                                                         14


<210> 2716
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2716
aacaucaagg aagauggcau uucuag                                            26


<210> 2717
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2717
aacaucaagg aagauggcau uucua                                             25


<210> 2718
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2718
aacaucaagg aagauggcau uucu                                              24


<210> 2719
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2719
aacaucaagg aagauggcau uuc                                               23


<210> 2720
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2720
aacaucaagg aagauggcau uu                                                22


<210> 2721
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2721
aacaucaagg aagauggcau u                                                 21


<210> 2722
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2722
aacaucaagg aagauggcau                                                   20


<210> 2723
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2723
aacaucaagg aagauggca                                                    19


<210> 2724
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2724
aacaucaagg aagauggc                                                     18


<210> 2725
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2725
aacaucaagg aagaugg                                                      17


<210> 2726
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2726
aacaucaagg aagaug                                                       16


<210> 2727
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2727
aacaucaagg aagau                                                        15


<210> 2728
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2728
aacaucaagg aaga                                                         14


<210> 2729
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2729
aacaucaagg aag                                                          13


<210> 2730
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2730
acaucaagga agauggcauu ucuag                                             25


<210> 2731
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2731
acaucaagga agauggcauu ucua                                              24


<210> 2732
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2732
acaucaagga agauggcauu ucu                                               23


<210> 2733
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2733
acaucaagga agauggcauu uc                                                22


<210> 2734
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2734
acaucaagga agauggcauu u                                                 21


<210> 2735
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2735
acaucaagga agauggcauu                                                   20


<210> 2736
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2736
acaucaagga agauggcau                                                    19


<210> 2737
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2737
acaucaagga agauggca                                                     18


<210> 2738
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2738
acaucaagga agauggc                                                      17


<210> 2739
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2739
acaucaagga agaugg                                                       16


<210> 2740
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2740
acaucaagga agaug                                                        15


<210> 2741
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2741
acaucaagga agau                                                         14


<210> 2742
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2742
acaucaagga aga                                                          13


<210> 2743
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2743
acaucaagga ag                                                           12


<210> 2744
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2744
caucaaggaa gauggcauuu cuag                                              24


<210> 2745
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2745
caucaaggaa gauggcauuu cua                                               23


<210> 2746
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2746
caucaaggaa gauggcauuu cu                                                22


<210> 2747
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2747
caucaaggaa gauggcauuu c                                                 21


<210> 2748
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2748
caucaaggaa gauggcauuu                                                   20


<210> 2749
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2749
caucaaggaa gauggcauu                                                    19


<210> 2750
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2750
caucaaggaa gauggcau                                                     18


<210> 2751
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2751
caucaaggaa gauggca                                                      17


<210> 2752
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2752
caucaaggaa gauggc                                                       16


<210> 2753
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2753
caucaaggaa gaugg                                                        15


<210> 2754
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2754
caucaaggaa gaug                                                         14


<210> 2755
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2755
caucaaggaa gau                                                          13


<210> 2756
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2756
caucaaggaa ga                                                           12


<210> 2757
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2757
caucaaggaa g                                                            11


<210> 2758
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2758
aucaaggaag auggcauuuc uag                                               23


<210> 2759
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2759
aucaaggaag auggcauuuc ua                                                22


<210> 2760
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2760
aucaaggaag auggcauuuc u                                                 21


<210> 2761
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2761
aucaaggaag auggcauuuc                                                   20


<210> 2762
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2762
aucaaggaag auggcauuu                                                    19


<210> 2763
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2763
aucaaggaag auggcauu                                                     18


<210> 2764
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2764
aucaaggaag auggcau                                                      17


<210> 2765
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2765
aucaaggaag auggca                                                       16


<210> 2766
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2766
aucaaggaag auggc                                                        15


<210> 2767
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2767
aucaaggaag augg                                                         14


<210> 2768
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2768
aucaaggaag aug                                                          13


<210> 2769
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2769
aucaaggaag au                                                           12


<210> 2770
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2770
aucaaggaag a                                                            11


<210> 2771
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2771
aucaaggaag                                                              10


<210> 2772
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2772
ccagagcagg uaccuccaac auc                                               23


<210> 2773
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2773
ccagagcagg uaccucca                                                     18


<210> 2774
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2774
ccucugugau uuuauaacuu gau                                               23


<210> 2775
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2775
ucacccacca ucacccu                                                      17


<210> 2776
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2776
ugauauccuc aaggucaccc                                                   20


<210> 2777
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2777
cugcuugaug aucaucucgu ug                                                22


<210> 2778
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2778
cugcuugaug aucaucuc                                                     18


<210> 2779
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2779
guuuccuuag uaaccacag                                                    19


<210> 2780
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2780
guuuccuuag uaaccac                                                      17


<210> 2781
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2781
ucaaggaaga uggcauuucu                                                   20


<210> 2782
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2782
ucaaggaaga uggcauuucu ag                                                22


<210> 2783
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2783
gguaaguucu guccaagc                                                     18


<210> 2784
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2784
guaaguucug uccaagcc                                                     18


<210> 2785
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2785
agucgguaag uucugucc                                                     18


<210> 2786
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2786
cuguccaagc ccgguuga                                                     18


<210> 2787
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2787
uaaguucugu ccaag                                                        15


<210> 2788
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2788
uucuguccaa gcccgguuga                                                   20


<210> 2789
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2789
uucuguccaa gcccgguug                                                    19


<210> 2790
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2790
uucuguccaa gcccgguu                                                     18


<210> 2791
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2791
uucuguccaa gcccggu                                                      17


<210> 2792
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2792
uucuguccaa gcccgg                                                       16


<210> 2793
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2793
uucuguccaa gcccg                                                        15


<210> 2794
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2794
uucuguccaa gccc                                                         14


<210> 2795
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2795
uucuguccaa gcc                                                          13


<210> 2796
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2796
uucuguccaa gc                                                           12


<210> 2797
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2797
uucuguccaa g                                                            11


<210> 2798
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2798
uucuguccaa                                                              10


<210> 2799
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2799
uucugucca                                                                9


<210> 2800
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2800
uucugucc                                                                 8


<210> 2801
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2801
ucuguccaag cccgguuga                                                    19


<210> 2802
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2802
ucuguccaag cccgguug                                                     18


<210> 2803
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2803
ucuguccaag cccgguu                                                      17


<210> 2804
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2804
ucuguccaag cccggu                                                       16


<210> 2805
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2805
ucuguccaag cccgg                                                        15


<210> 2806
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2806
ucuguccaag cccg                                                         14


<210> 2807
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2807
ucuguccaag ccc                                                          13


<210> 2808
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2808
ucuguccaag cc                                                           12


<210> 2809
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2809
ucuguccaag c                                                            11


<210> 2810
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2810
ucuguccaag                                                              10


<210> 2811
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2811
ucuguccaa                                                                9


<210> 2812
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2812
ucugucca                                                                 8


<210> 2813
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2813
cuguccaagc ccgguug                                                      17


<210> 2814
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2814
cuguccaagc ccgguu                                                       16


<210> 2815
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2815
cuguccaagc ccggu                                                        15


<210> 2816
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2816
cuguccaagc ccgg                                                         14


<210> 2817
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2817
cuguccaagc ccg                                                          13


<210> 2818
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2818
cuguccaagc cc                                                           12


<210> 2819
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2819
cuguccaagc c                                                            11


<210> 2820
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2820
cuguccaagc                                                              10


<210> 2821
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2821
cuguccaag                                                                9


<210> 2822
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2822
cuguccaa                                                                 8


<210> 2823
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2823
guucugucca agcccgguug                                                   20


<210> 2824
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2824
guucugucca agcccgguu                                                    19


<210> 2825
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2825
guucugucca agcccggu                                                     18


<210> 2826
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2826
guucugucca agcccgg                                                      17


<210> 2827
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2827
guucugucca agcccg                                                       16


<210> 2828
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2828
guucugucca agccc                                                        15


<210> 2829
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2829
guucugucca agcc                                                         14


<210> 2830
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2830
guucugucca agc                                                          13


<210> 2831
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2831
guucugucca ag                                                           12


<210> 2832
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2832
guucugucca a                                                            11


<210> 2833
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2833
guucugucca                                                              10


<210> 2834
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2834
guucugucc                                                                9


<210> 2835
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2835
guucuguc                                                                 8


<210> 2836
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2836
aguucugucc aagcccgguu                                                   20


<210> 2837
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2837
aguucugucc aagcccggu                                                    19


<210> 2838
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2838
aguucugucc aagcccgg                                                     18


<210> 2839
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2839
aguucugucc aagcccg                                                      17


<210> 2840
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2840
aguucugucc aagccc                                                       16


<210> 2841
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2841
aguucugucc aagcc                                                        15


<210> 2842
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2842
aguucugucc aagc                                                         14


<210> 2843
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2843
aguucugucc aag                                                          13


<210> 2844
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2844
aguucugucc aa                                                           12


<210> 2845
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2845
aguucugucc a                                                            11


<210> 2846
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2846
aguucugucc                                                              10


<210> 2847
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2847
aguucuguc                                                                9


<210> 2848
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2848
aguucugu                                                                 8


<210> 2849
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2849
aaguucuguc caagcccggu                                                   20


<210> 2850
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2850
aaguucuguc caagcccgg                                                    19


<210> 2851
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2851
aaguucuguc caagcccg                                                     18


<210> 2852
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2852
aaguucuguc caagccc                                                      17


<210> 2853
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2853
aaguucuguc caagcc                                                       16


<210> 2854
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2854
aaguucuguc caagc                                                        15


<210> 2855
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2855
aaguucuguc caag                                                         14


<210> 2856
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2856
aaguucuguc caa                                                          13


<210> 2857
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2857
aaguucuguc ca                                                           12


<210> 2858
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2858
aaguucuguc c                                                            11


<210> 2859
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2859
aaguucuguc                                                              10


<210> 2860
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2860
aaguucugu                                                                9


<210> 2861
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2861
aaguucug                                                                 8


<210> 2862
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2862
uaaguucugu ccaagcccgg                                                   20


<210> 2863
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2863
uaaguucugu ccaagcccg                                                    19


<210> 2864
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2864
uaaguucugu ccaagccc                                                     18


<210> 2865
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2865
uaaguucugu ccaagcc                                                      17


<210> 2866
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2866
uaaguucugu ccaagc                                                       16


<210> 2867
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2867
uaaguucugu ccaa                                                         14


<210> 2868
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2868
uaaguucugu cca                                                          13


<210> 2869
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2869
uaaguucugu cc                                                           12


<210> 2870
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2870
uaaguucugu c                                                            11


<210> 2871
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2871
uaaguucugu                                                              10


<210> 2872
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2872
uaaguucug                                                                9


<210> 2873
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2873
uaaguucu                                                                 8


<210> 2874
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2874
guaaguucug uccaagcccg                                                   20


<210> 2875
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2875
guaaguucug uccaagccc                                                    19


<210> 2876
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2876
guaaguucug uccaagc                                                      17


<210> 2877
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2877
guaaguucug uccaag                                                       16


<210> 2878
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2878
guaaguucug uccaa                                                        15


<210> 2879
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2879
guaaguucug ucca                                                         14


<210> 2880
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2880
guaaguucug ucc                                                          13


<210> 2881
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2881
guaaguucug uc                                                           12


<210> 2882
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2882
guaaguucug u                                                            11


<210> 2883
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2883
guaaguucug                                                              10


<210> 2884
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2884
guaaguucu                                                                9


<210> 2885
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2885
guaaguuc                                                                 8


<210> 2886
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2886
gguaaguucu guccaagccc                                                   20


<210> 2887
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2887
gguaaguucu guccaagcc                                                    19


<210> 2888
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2888
gguaaguucu guccaag                                                      17


<210> 2889
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2889
gguaaguucu guccaa                                                       16


<210> 2890
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2890
gguaaguucu gucca                                                        15


<210> 2891
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2891
gguaaguucu gucc                                                         14


<210> 2892
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2892
gguaaguucu guc                                                          13


<210> 2893
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2893
gguaaguucu gu                                                           12


<210> 2894
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2894
gguaaguucu g                                                            11


<210> 2895
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2895
gguaaguucu                                                              10


<210> 2896
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2896
gguaaguuc                                                                9


<210> 2897
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"

<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2897
gguaaguu                                                                 8


<210> 2898
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2898
cgguaaguuc uguccaagcc                                                   20


<210> 2899
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2899
cgguaaguuc uguccaagc                                                    19


<210> 2900
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2900
cgguaaguuc uguccaag                                                     18


<210> 2901
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2901
cgguaaguuc uguccaa                                                      17


<210> 2902
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2902
cgguaaguuc ugucca                                                       16


<210> 2903
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2903
cgguaaguuc ugucc                                                        15


<210> 2904
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2904
cgguaaguuc uguc                                                         14


<210> 2905
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2905
cgguaaguuc ugu                                                          13


<210> 2906
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2906
cgguaaguuc ug                                                           12


<210> 2907
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2907
cgguaaguuc u                                                            11


<210> 2908
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2908
cgguaaguuc                                                              10


<210> 2909
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2909
cgguaaguu                                                                9


<210> 2910
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2910
cgguaagu                                                                 8


<210> 2911
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2911
ucgguaaguu cuguccaagc                                                   20


<210> 2912
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2912
ucgguaaguu cuguccaag                                                    19


<210> 2913
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2913
ucgguaaguu cuguccaa                                                     18


<210> 2914
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2914
ucgguaaguu cugucca                                                      17


<210> 2915
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2915
ucgguaaguu cugucc                                                       16


<210> 2916
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2916
ucgguaaguu cuguc                                                        15


<210> 2917
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2917
ucgguaaguu cugu                                                         14


<210> 2918
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2918
ucgguaaguu cug                                                          13


<210> 2919
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2919
ucgguaaguu cu                                                           12


<210> 2920
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2920
ucgguaaguu c                                                            11


<210> 2921
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2921
ucgguaaguu                                                              10


<210> 2922
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2922
ucgguaagu                                                                9


<210> 2923
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2923
gucgguaagu ucuguccaag                                                   20


<210> 2924
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2924
gucgguaagu ucuguccaa                                                    19


<210> 2925
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2925
gucgguaagu ucugucca                                                     18


<210> 2926
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2926
gucgguaagu ucugucc                                                      17


<210> 2927
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2927
gucgguaagu ucuguc                                                       16


<210> 2928
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2928
gucgguaagu ucugu                                                        15


<210> 2929
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2929
gucgguaagu ucug                                                         14


<210> 2930
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2930
gucgguaagu ucu                                                          13


<210> 2931
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2931
gucgguaagu uc                                                           12


<210> 2932
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2932
gucgguaagu u                                                            11


<210> 2933
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2933
gucgguaagu                                                              10


<210> 2934
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2934
agucgguaag uucuguccaa                                                   20


<210> 2935
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2935
agucgguaag uucugucca                                                    19


<210> 2936
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2936
agucgguaag uucuguc                                                      17


<210> 2937
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2937
agucgguaag uucugu                                                       16


<210> 2938
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2938
agucgguaag uucug                                                        15


<210> 2939
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2939
agucgguaag uucu                                                         14


<210> 2940
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2940
agucgguaag uuc                                                          13


<210> 2941
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2941
agucgguaag uu                                                           12


<210> 2942
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2942
agucgguaag u                                                            11


<210> 2943
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2943
cagucgguaa guucugucca                                                   20


<210> 2944
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2944
cagucgguaa guucugucc                                                    19


<210> 2945
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2945
cagucgguaa guucuguc                                                     18


<210> 2946
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2946
cagucgguaa guucugu                                                      17


<210> 2947
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2947
cagucgguaa guucug                                                       16


<210> 2948
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2948
cagucgguaa guucu                                                        15


<210> 2949
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2949
cagucgguaa guuc                                                         14


<210> 2950
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2950
cagucgguaa guu                                                          13


<210> 2951
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2951
cagucgguaa gu                                                           12


<210> 2952
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2952
ccagucggua aguucugucc                                                   20


<210> 2953
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2953
ccagucggua aguucuguc                                                    19


<210> 2954
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2954
ccagucggua aguucugu                                                     18


<210> 2955
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2955
ccagucggua aguucug                                                      17


<210> 2956
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2956
ccagucggua aguucu                                                       16


<210> 2957
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2957
ccagucggua aguuc                                                        15


<210> 2958
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2958
ccagucggua aguu                                                         14


<210> 2959
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2959
ccagucggua agu                                                          13


<210> 2960
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2960
gccagucggu aaguucuguc                                                   20


<210> 2961
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2961
gccagucggu aaguucugu                                                    19


<210> 2962
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2962
gccagucggu aaguucug                                                     18


<210> 2963
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2963
gccagucggu aaguucu                                                      17


<210> 2964
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2964
gccagucggu aaguuc                                                       16


<210> 2965
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2965
gccagucggu aaguu                                                        15


<210> 2966
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2966
gccagucggu aagu                                                         14


<210> 2967
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2967
ucaaggaaga uggcauuucu                                                   20


<210> 2968
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2968
ucaaggaaga uggcauuucu ag                                                22


<210> 2969
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2969
ucaaggaaga uggcau                                                       16


<210> 2970
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2970
gaagauggca uuucu                                                        15


<210> 2971
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2971
ucaaggaaga uggcauuucu a                                                 21


<210> 2972
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2972
ucaaggaaga uggcauuuc                                                    19


<210> 2973
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2973
ucaaggaaga uggcauuu                                                     18


<210> 2974
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2974
ucaaggaaga uggcauu                                                      17


<210> 2975
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2975
ucaaggaaga uggca                                                        15


<210> 2976
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2976
ucaaggaaga uggc                                                         14


<210> 2977
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2977
ucaaggaaga ugg                                                          13


<210> 2978
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2978
ucaaggaaga ug                                                           12


<210> 2979
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2979
ucaaggaaga u                                                            11


<210> 2980
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2980
ucaaggaaga                                                              10


<210> 2981
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2981
ucaaggaag                                                                9


<210> 2982
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2982
caaggaagau ggcauuucua g                                                 21


<210> 2983
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2983
caaggaagau ggcauuucua                                                   20


<210> 2984
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2984
caaggaagau ggcauuucu                                                    19


<210> 2985
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2985
caaggaagau ggcauuuc                                                     18


<210> 2986
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2986
caaggaagau ggcauuu                                                      17


<210> 2987
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2987
caaggaagau ggcauu                                                       16


<210> 2988
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2988
caaggaagau ggcau                                                        15


<210> 2989
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2989
caaggaagau ggca                                                         14


<210> 2990
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2990
caaggaagau ggc                                                          13


<210> 2991
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2991
caaggaagau gg                                                           12


<210> 2992
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2992
caaggaagau g                                                            11


<210> 2993
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2993
caaggaagau                                                              10


<210> 2994
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2994
caaggaaga                                                                9


<210> 2995
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2995
caaggaag                                                                 8


<210> 2996
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2996
aaggaagaug gcauuucuag                                                   20


<210> 2997
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2997
aaggaagaug gcauuucua                                                    19


<210> 2998
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2998
aaggaagaug gcauuucu                                                     18


<210> 2999
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 2999
aaggaagaug gcauuuc                                                      17


<210> 3000
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3000
aaggaagaug gcauuu                                                       16


<210> 3001
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3001
aaggaagaug gcauu                                                        15


<210> 3002
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3002
aaggaagaug gcau                                                         14


<210> 3003
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3003
aaggaagaug gca                                                          13


<210> 3004
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3004
aaggaagaug gc                                                           12


<210> 3005
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3005
aaggaagaug g                                                            11


<210> 3006
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3006
aaggaagaug                                                              10


<210> 3007
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3007
aaggaagau                                                                9


<210> 3008
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3008
aaggaaga                                                                 8


<210> 3009
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3009
aggaagaugg cauuucuag                                                    19


<210> 3010
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3010
aggaagaugg cauuucua                                                     18


<210> 3011
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3011
aggaagaugg cauuucu                                                      17


<210> 3012
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3012
aggaagaugg cauuuc                                                       16


<210> 3013
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3013
aggaagaugg cauuu                                                        15


<210> 3014
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3014
aggaagaugg cauu                                                         14


<210> 3015
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3015
aggaagaugg cau                                                          13


<210> 3016
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3016
aggaagaugg ca                                                           12


<210> 3017
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3017
aggaagaugg                                                              10


<210> 3018
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3018
aggaagaug                                                                9


<210> 3019
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3019
aggaagau                                                                 8


<210> 3020
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3020
ggaagauggc auuucuag                                                     18


<210> 3021
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3021
ggaagauggc auuucua                                                      17


<210> 3022
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3022
ggaagauggc auuucu                                                       16


<210> 3023
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3023
ggaagauggc auuuc                                                        15


<210> 3024
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3024
ggaagauggc auuu                                                         14


<210> 3025
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3025
ggaagauggc auu                                                          13


<210> 3026
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3026
ggaagauggc au                                                           12


<210> 3027
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3027
ggaagauggc a                                                            11


<210> 3028
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3028
ggaagauggc                                                              10


<210> 3029
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3029
ggaagaug                                                                 8


<210> 3030
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3030
gaagauggca uuucuag                                                      17


<210> 3031
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3031
gaagauggca uuucua                                                       16


<210> 3032
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3032
gaagauggca uuuc                                                         14


<210> 3033
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3033
gaagauggca uuu                                                          13


<210> 3034
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3034
gaagauggca uu                                                           12


<210> 3035
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3035
gaagauggca u                                                            11


<210> 3036
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3036
gaagauggca                                                              10


<210> 3037
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3037
gaagauggc                                                                9


<210> 3038
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3038
gaagaugg                                                                 8


<210> 3039
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3039
aagauggcau uucuag                                                       16


<210> 3040
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3040
aagauggcau uucua                                                        15


<210> 3041
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3041
aagauggcau uucu                                                         14


<210> 3042
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3042
aagauggcau uuc                                                          13


<210> 3043
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3043
aagauggcau uu                                                           12


<210> 3044
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3044
aagauggcau u                                                            11


<210> 3045
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3045
aagauggcau                                                              10


<210> 3046
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3046
aagauggca                                                                9


<210> 3047
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3047
aagauggc                                                                 8


<210> 3048
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3048
agauggcauu ucuag                                                        15


<210> 3049
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3049
agauggcauu ucua                                                         14


<210> 3050
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3050
agauggcauu ucu                                                          13


<210> 3051
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3051
agauggcauu uc                                                           12


<210> 3052
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3052
agauggcauu u                                                            11


<210> 3053
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3053
agauggcauu                                                              10


<210> 3054
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3054
agauggcau                                                                9


<210> 3055
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3055
agauggca                                                                 8


<210> 3056
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3056
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 3057
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3057
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 3058
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3058
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 3059
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3059
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 3060
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3060
cuccaacauc aaggaagaug gcauuu                                            26


<210> 3061
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3061
cuccaacauc aaggaagaug gcauu                                             25


<210> 3062
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3062
cuccaacauc aaggaagaug gcau                                              24


<210> 3063
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3063
cuccaacauc aaggaagaug gca                                               23


<210> 3064
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3064
cuccaacauc aaggaagaug gc                                                22


<210> 3065
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3065
cuccaacauc aaggaagaug g                                                 21


<210> 3066
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3066
cuccaacauc aaggaagaug                                                   20


<210> 3067
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3067
cuccaacauc aaggaagau                                                    19


<210> 3068
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3068
cuccaacauc aaggaaga                                                     18


<210> 3069
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3069
cuccaacauc aaggaag                                                      17


<210> 3070
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3070
uccaacauca aggaagaugg cauuucuag                                         29


<210> 3071
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3071
uccaacauca aggaagaugg cauuucua                                          28


<210> 3072
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3072
uccaacauca aggaagaugg cauuucu                                           27


<210> 3073
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3073
uccaacauca aggaagaugg cauuuc                                            26


<210> 3074
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3074
uccaacauca aggaagaugg cauuu                                             25


<210> 3075
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3075
uccaacauca aggaagaugg cauu                                              24


<210> 3076
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3076
uccaacauca aggaagaugg cau                                               23


<210> 3077
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3077
uccaacauca aggaagaugg ca                                                22


<210> 3078
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3078
uccaacauca aggaagaugg c                                                 21


<210> 3079
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3079
uccaacauca aggaagaugg                                                   20


<210> 3080
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3080
uccaacauca aggaagaug                                                    19


<210> 3081
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3081
uccaacauca aggaagau                                                     18


<210> 3082
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3082
uccaacauca aggaaga                                                      17


<210> 3083
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3083
uccaacauca aggaag                                                       16


<210> 3084
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3084
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 3085
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3085
ccaacaucaa ggaagauggc auuucua                                           27


<210> 3086
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3086
ccaacaucaa ggaagauggc auuucu                                            26


<210> 3087
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3087
ccaacaucaa ggaagauggc auuuc                                             25


<210> 3088
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3088
ccaacaucaa ggaagauggc auuu                                              24


<210> 3089
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3089
ccaacaucaa ggaagauggc auu                                               23


<210> 3090
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3090
ccaacaucaa ggaagauggc au                                                22


<210> 3091
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3091
ccaacaucaa ggaagauggc a                                                 21


<210> 3092
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3092
ccaacaucaa ggaagauggc                                                   20


<210> 3093
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3093
ccaacaucaa ggaagaugg                                                    19


<210> 3094
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3094
ccaacaucaa ggaagaug                                                     18


<210> 3095
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3095
ccaacaucaa ggaagau                                                      17


<210> 3096
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3096
ccaacaucaa ggaaga                                                       16


<210> 3097
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3097
ccaacaucaa ggaag                                                        15


<210> 3098
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3098
caacaucaag gaagauggca uuucuag                                           27


<210> 3099
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3099
caacaucaag gaagauggca uuucua                                            26


<210> 3100
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3100
caacaucaag gaagauggca uuucu                                             25


<210> 3101
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3101
caacaucaag gaagauggca uuuc                                              24


<210> 3102
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3102
caacaucaag gaagauggca uuu                                               23


<210> 3103
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3103
caacaucaag gaagauggca uu                                                22


<210> 3104
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3104
caacaucaag gaagauggca u                                                 21


<210> 3105
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3105
caacaucaag gaagauggca                                                   20


<210> 3106
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3106
caacaucaag gaagauggc                                                    19


<210> 3107
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3107
caacaucaag gaagaugg                                                     18


<210> 3108
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3108
caacaucaag gaagaug                                                      17


<210> 3109
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3109
caacaucaag gaagau                                                       16


<210> 3110
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3110
caacaucaag gaaga                                                        15


<210> 3111
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3111
caacaucaag gaag                                                         14


<210> 3112
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3112
aacaucaagg aagauggcau uucuag                                            26


<210> 3113
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3113
aacaucaagg aagauggcau uucua                                             25


<210> 3114
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3114
aacaucaagg aagauggcau uucu                                              24


<210> 3115
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3115
aacaucaagg aagauggcau uuc                                               23


<210> 3116
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3116
aacaucaagg aagauggcau uu                                                22


<210> 3117
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3117
aacaucaagg aagauggcau u                                                 21


<210> 3118
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3118
aacaucaagg aagauggcau                                                   20


<210> 3119
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3119
aacaucaagg aagauggca                                                    19


<210> 3120
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3120
aacaucaagg aagauggc                                                     18


<210> 3121
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3121
aacaucaagg aagaugg                                                      17


<210> 3122
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3122
aacaucaagg aagaug                                                       16


<210> 3123
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3123
aacaucaagg aagau                                                        15


<210> 3124
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3124
aacaucaagg aaga                                                         14


<210> 3125
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3125
aacaucaagg aag                                                          13


<210> 3126
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3126
acaucaagga agauggcauu ucuag                                             25


<210> 3127
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3127
acaucaagga agauggcauu ucua                                              24


<210> 3128
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3128
acaucaagga agauggcauu ucu                                               23


<210> 3129
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3129
acaucaagga agauggcauu uc                                                22


<210> 3130
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3130
acaucaagga agauggcauu u                                                 21


<210> 3131
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3131
acaucaagga agauggcauu                                                   20


<210> 3132
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3132
acaucaagga agauggcau                                                    19


<210> 3133
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3133
acaucaagga agauggca                                                     18


<210> 3134
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3134
acaucaagga agauggc                                                      17


<210> 3135
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3135
acaucaagga agaugg                                                       16


<210> 3136
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3136
acaucaagga agaug                                                        15


<210> 3137
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3137
acaucaagga agau                                                         14


<210> 3138
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3138
acaucaagga aga                                                          13


<210> 3139
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3139
acaucaagga ag                                                           12


<210> 3140
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3140
caucaaggaa gauggcauuu cuag                                              24


<210> 3141
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3141
caucaaggaa gauggcauuu cua                                               23


<210> 3142
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3142
caucaaggaa gauggcauuu cu                                                22


<210> 3143
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3143
caucaaggaa gauggcauuu c                                                 21


<210> 3144
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3144
caucaaggaa gauggcauuu                                                   20


<210> 3145
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3145
caucaaggaa gauggcauu                                                    19


<210> 3146
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3146
caucaaggaa gauggcau                                                     18


<210> 3147
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3147
caucaaggaa gauggca                                                      17


<210> 3148
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3148
caucaaggaa gauggc                                                       16


<210> 3149
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3149
caucaaggaa gaugg                                                        15


<210> 3150
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3150
caucaaggaa gaug                                                         14


<210> 3151
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3151
caucaaggaa gau                                                          13


<210> 3152
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3152
caucaaggaa ga                                                           12


<210> 3153
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3153
caucaaggaa g                                                            11


<210> 3154
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3154
aucaaggaag auggcauuuc uag                                               23


<210> 3155
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3155
aucaaggaag auggcauuuc ua                                                22


<210> 3156
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3156
aucaaggaag auggcauuuc u                                                 21


<210> 3157
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3157
aucaaggaag auggcauuuc                                                   20


<210> 3158
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3158
aucaaggaag auggcauuu                                                    19


<210> 3159
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3159
aucaaggaag auggcauu                                                     18


<210> 3160
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3160
aucaaggaag auggcau                                                      17


<210> 3161
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3161
aucaaggaag auggca                                                       16


<210> 3162
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3162
aucaaggaag auggc                                                        15


<210> 3163
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3163
aucaaggaag augg                                                         14


<210> 3164
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3164
aucaaggaag aug                                                          13


<210> 3165
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3165
aucaaggaag au                                                           12


<210> 3166
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3166
aucaaggaag a                                                            11


<210> 3167
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3167
aucaaggaag                                                              10


<210> 3168
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3168
ccagagcagg uaccuccaac auc                                               23


<210> 3169
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3169
ccagagcagg uaccucca                                                     18


<210> 3170
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3170
ccucugugau uuuauaacuu gau                                               23


<210> 3171
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3171
ucacccacca ucacccu                                                      17


<210> 3172
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3172
ugauauccuc aaggucaccc                                                   20


<210> 3173
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3173
cugcuugaug aucaucucgu ug                                                22


<210> 3174
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3174
cugcuugaug aucaucuc                                                     18


<210> 3175
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3175
guuuccuuag uaaccacag                                                    19


<210> 3176
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3176
guuuccuuag uaaccac                                                      17


<210> 3177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3177
tcaaggaaga uggcauuucu                                                   20


<210> 3178
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3178
tcaaggaaga uggcauuucu ag                                                22


<210> 3179
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3179
gguaaguucu guccaagc                                                     18


<210> 3180
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3180
guaaguucug uccaagcc                                                     18


<210> 3181
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3181
agucgguaag uucugucc                                                     18


<210> 3182
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3182
cuguccaagc ccgguuga                                                     18


<210> 3183
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3183
taaguucugu ccaag                                                        15


<210> 3184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3184
tucuguccaa gcccgguuga                                                   20


<210> 3185
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3185
tucuguccaa gcccgguug                                                    19


<210> 3186
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3186
tucuguccaa gcccgguu                                                     18


<210> 3187
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3187
tucuguccaa gcccggu                                                      17


<210> 3188
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3188
tucuguccaa gcccgg                                                       16


<210> 3189
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3189
tucuguccaa gcccg                                                        15


<210> 3190
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3190
tucuguccaa gccc                                                         14


<210> 3191
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3191
tucuguccaa gcc                                                          13


<210> 3192
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3192
tucuguccaa gc                                                           12


<210> 3193
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3193
tucuguccaa g                                                            11


<210> 3194
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3194
tucuguccaa                                                              10


<210> 3195
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3195
tucugucca                                                                9


<210> 3196
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3196
tucugucc                                                                 8


<210> 3197
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3197
tcuguccaag cccgguuga                                                    19


<210> 3198
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3198
tcuguccaag cccgguug                                                     18


<210> 3199
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3199
tcuguccaag cccgguu                                                      17


<210> 3200
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3200
tcuguccaag cccggu                                                       16


<210> 3201
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3201
tcuguccaag cccgg                                                        15


<210> 3202
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3202
tcuguccaag cccg                                                         14


<210> 3203
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3203
tcuguccaag ccc                                                          13


<210> 3204
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3204
tcuguccaag cc                                                           12


<210> 3205
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3205
tcuguccaag c                                                            11


<210> 3206
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3206
tcuguccaag                                                              10


<210> 3207
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3207
tcuguccaa                                                                9


<210> 3208
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3208
tcugucca                                                                 8


<210> 3209
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3209
cuguccaagc ccgguug                                                      17


<210> 3210
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3210
cuguccaagc ccgguu                                                       16


<210> 3211
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3211
cuguccaagc ccggu                                                        15


<210> 3212
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3212
cuguccaagc ccgg                                                         14


<210> 3213
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3213
cuguccaagc ccg                                                          13


<210> 3214
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3214
cuguccaagc cc                                                           12


<210> 3215
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3215
cuguccaagc c                                                            11


<210> 3216
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3216
cuguccaagc                                                              10


<210> 3217
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3217
cuguccaag                                                                9


<210> 3218
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3218
cuguccaa                                                                 8


<210> 3219
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3219
guucugucca agcccgguug                                                   20


<210> 3220
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3220
guucugucca agcccgguu                                                    19


<210> 3221
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3221
guucugucca agcccggu                                                     18


<210> 3222
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3222
guucugucca agcccgg                                                      17


<210> 3223
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3223
guucugucca agcccg                                                       16


<210> 3224
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3224
guucugucca agccc                                                        15


<210> 3225
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3225
guucugucca agcc                                                         14


<210> 3226
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3226
guucugucca agc                                                          13


<210> 3227
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3227
guucugucca ag                                                           12


<210> 3228
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3228
guucugucca a                                                            11


<210> 3229
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3229
guucugucca                                                              10


<210> 3230
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3230
guucugucc                                                                9


<210> 3231
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3231
guucuguc                                                                 8


<210> 3232
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3232
aguucugucc aagcccgguu                                                   20


<210> 3233
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3233
aguucugucc aagcccggu                                                    19


<210> 3234
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3234
aguucugucc aagcccgg                                                     18


<210> 3235
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3235
aguucugucc aagcccg                                                      17


<210> 3236
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3236
aguucugucc aagccc                                                       16


<210> 3237
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3237
aguucugucc aagcc                                                        15


<210> 3238
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3238
aguucugucc aagc                                                         14


<210> 3239
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3239
aguucugucc aag                                                          13


<210> 3240
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3240
aguucugucc aa                                                           12


<210> 3241
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3241
aguucugucc a                                                            11


<210> 3242
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3242
aguucugucc                                                              10


<210> 3243
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3243
aguucuguc                                                                9


<210> 3244
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3244
aguucugu                                                                 8


<210> 3245
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3245
aaguucuguc caagcccggu                                                   20


<210> 3246
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3246
aaguucuguc caagcccgg                                                    19


<210> 3247
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3247
aaguucuguc caagcccg                                                     18


<210> 3248
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3248
aaguucuguc caagccc                                                      17


<210> 3249
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3249
aaguucuguc caagcc                                                       16


<210> 3250
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3250
aaguucuguc caagc                                                        15


<210> 3251
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3251
aaguucuguc caag                                                         14


<210> 3252
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3252
aaguucuguc caa                                                          13


<210> 3253
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3253
aaguucuguc ca                                                           12


<210> 3254
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3254
aaguucuguc c                                                            11


<210> 3255
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3255
aaguucuguc                                                              10


<210> 3256
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3256
aaguucugu                                                                9


<210> 3257
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3257
aaguucug                                                                 8


<210> 3258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3258
taaguucugu ccaagcccgg                                                   20


<210> 3259
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3259
taaguucugu ccaagcccg                                                    19


<210> 3260
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3260
taaguucugu ccaagccc                                                     18


<210> 3261
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3261
taaguucugu ccaagcc                                                      17


<210> 3262
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3262
taaguucugu ccaagc                                                       16


<210> 3263
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3263
taaguucugu ccaa                                                         14


<210> 3264
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3264
taaguucugu cca                                                          13


<210> 3265
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3265
taaguucugu cc                                                           12


<210> 3266
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3266
taaguucugu c                                                            11


<210> 3267
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3267
taaguucugu                                                              10


<210> 3268
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3268
taaguucug                                                                9


<210> 3269
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3269
taaguucu                                                                 8


<210> 3270
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3270
guaaguucug uccaagcccg                                                   20


<210> 3271
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3271
guaaguucug uccaagccc                                                    19


<210> 3272
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3272
guaaguucug uccaagc                                                      17


<210> 3273
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3273
guaaguucug uccaag                                                       16


<210> 3274
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3274
guaaguucug uccaa                                                        15


<210> 3275
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3275
guaaguucug ucca                                                         14


<210> 3276
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3276
guaaguucug ucc                                                          13


<210> 3277
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3277
guaaguucug uc                                                           12


<210> 3278
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3278
guaaguucug u                                                            11


<210> 3279
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3279
guaaguucug                                                              10


<210> 3280
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3280
guaaguucu                                                                9


<210> 3281
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3281
guaaguuc                                                                 8


<210> 3282
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3282
gguaaguucu guccaagccc                                                   20


<210> 3283
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3283
gguaaguucu guccaagcc                                                    19


<210> 3284
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3284
gguaaguucu guccaag                                                      17


<210> 3285
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3285
gguaaguucu guccaa                                                       16


<210> 3286
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3286
gguaaguucu gucca                                                        15


<210> 3287
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3287
gguaaguucu gucc                                                         14


<210> 3288
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3288
gguaaguucu guc                                                          13


<210> 3289
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3289
gguaaguucu gu                                                           12


<210> 3290
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3290
gguaaguucu g                                                            11


<210> 3291
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3291
gguaaguucu                                                              10


<210> 3292
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3292
gguaaguuc                                                                9


<210> 3293
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3293
gguaaguu                                                                 8


<210> 3294
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3294
cgguaaguuc uguccaagcc                                                   20


<210> 3295
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3295
cgguaaguuc uguccaagc                                                    19


<210> 3296
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3296
cgguaaguuc uguccaag                                                     18


<210> 3297
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3297
cgguaaguuc uguccaa                                                      17


<210> 3298
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3298
cgguaaguuc ugucca                                                       16


<210> 3299
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3299
cgguaaguuc ugucc                                                        15


<210> 3300
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3300
cgguaaguuc uguc                                                         14


<210> 3301
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3301
cgguaaguuc ugu                                                          13


<210> 3302
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3302
cgguaaguuc ug                                                           12


<210> 3303
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3303
cgguaaguuc u                                                            11


<210> 3304
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3304
cgguaaguuc                                                              10


<210> 3305
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3305
cgguaaguu                                                                9


<210> 3306
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3306
cgguaagu                                                                 8


<210> 3307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3307
tcgguaaguu cuguccaagc                                                   20


<210> 3308
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3308
tcgguaaguu cuguccaag                                                    19


<210> 3309
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3309
tcgguaaguu cuguccaa                                                     18


<210> 3310
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3310
tcgguaaguu cugucca                                                      17


<210> 3311
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3311
tcgguaaguu cugucc                                                       16


<210> 3312
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3312
tcgguaaguu cuguc                                                        15


<210> 3313
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3313
tcgguaaguu cugu                                                         14


<210> 3314
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3314
tcgguaaguu cug                                                          13


<210> 3315
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3315
tcgguaaguu cu                                                           12


<210> 3316
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3316
tcgguaaguu c                                                            11


<210> 3317
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3317
tcgguaaguu                                                              10


<210> 3318
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3318
tcgguaagu                                                                9


<210> 3319
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3319
gucgguaagu ucuguccaag                                                   20


<210> 3320
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3320
gucgguaagu ucuguccaa                                                    19


<210> 3321
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3321
gucgguaagu ucugucca                                                     18


<210> 3322
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3322
gucgguaagu ucugucc                                                      17


<210> 3323
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3323
gucgguaagu ucuguc                                                       16


<210> 3324
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3324
gucgguaagu ucugu                                                        15


<210> 3325
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3325
gucgguaagu ucug                                                         14


<210> 3326
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3326
gucgguaagu ucu                                                          13


<210> 3327
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3327
gucgguaagu uc                                                           12


<210> 3328
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3328
gucgguaagu u                                                            11


<210> 3329
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3329
gucgguaagu                                                              10


<210> 3330
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3330
agucgguaag uucuguccaa                                                   20


<210> 3331
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3331
agucgguaag uucugucca                                                    19


<210> 3332
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3332
agucgguaag uucuguc                                                      17


<210> 3333
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3333
agucgguaag uucugu                                                       16


<210> 3334
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3334
agucgguaag uucug                                                        15


<210> 3335
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3335
agucgguaag uucu                                                         14


<210> 3336
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3336
agucgguaag uuc                                                          13


<210> 3337
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3337
agucgguaag uu                                                           12


<210> 3338
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3338
agucgguaag u                                                            11


<210> 3339
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3339
cagucgguaa guucugucca                                                   20


<210> 3340
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3340
cagucgguaa guucugucc                                                    19


<210> 3341
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3341
cagucgguaa guucuguc                                                     18


<210> 3342
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3342
cagucgguaa guucugu                                                      17


<210> 3343
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3343
cagucgguaa guucug                                                       16


<210> 3344
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3344
cagucgguaa guucu                                                        15


<210> 3345
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3345
cagucgguaa guuc                                                         14


<210> 3346
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3346
cagucgguaa guu                                                          13


<210> 3347
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3347
cagucgguaa gu                                                           12


<210> 3348
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3348
ccagucggua aguucugucc                                                   20


<210> 3349
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3349
ccagucggua aguucuguc                                                    19


<210> 3350
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3350
ccagucggua aguucugu                                                     18


<210> 3351
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3351
ccagucggua aguucug                                                      17


<210> 3352
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3352
ccagucggua aguucu                                                       16


<210> 3353
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3353
ccagucggua aguuc                                                        15


<210> 3354
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3354
ccagucggua aguu                                                         14


<210> 3355
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3355
ccagucggua agu                                                          13


<210> 3356
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3356
gccagucggu aaguucuguc                                                   20


<210> 3357
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3357
gccagucggu aaguucugu                                                    19


<210> 3358
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3358
gccagucggu aaguucug                                                     18


<210> 3359
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3359
gccagucggu aaguucu                                                      17


<210> 3360
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3360
gccagucggu aaguuc                                                       16


<210> 3361
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3361
gccagucggu aaguu                                                        15


<210> 3362
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3362
gccagucggu aagu                                                         14


<210> 3363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3363
tcaaggaaga uggcauuucu                                                   20


<210> 3364
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3364
tcaaggaaga uggcauuucu ag                                                22


<210> 3365
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3365
tcaaggaaga uggcau                                                       16


<210> 3366
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3366
gaagauggca uuucu                                                        15


<210> 3367
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3367
tcaaggaaga uggcauuucu a                                                 21


<210> 3368
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3368
tcaaggaaga uggcauuuc                                                    19


<210> 3369
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3369
tcaaggaaga uggcauuu                                                     18


<210> 3370
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3370
tcaaggaaga uggcauu                                                      17


<210> 3371
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3371
tcaaggaaga uggca                                                        15


<210> 3372
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3372
tcaaggaaga uggc                                                         14


<210> 3373
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3373
tcaaggaaga ugg                                                          13


<210> 3374
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3374
tcaaggaaga ug                                                           12


<210> 3375
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3375
tcaaggaaga u                                                            11


<210> 3376
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3376
tcaaggaaga                                                              10


<210> 3377
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3377
tcaaggaag                                                                9


<210> 3378
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3378
caaggaagau ggcauuucua g                                                 21


<210> 3379
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3379
caaggaagau ggcauuucua                                                   20


<210> 3380
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3380
caaggaagau ggcauuucu                                                    19


<210> 3381
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3381
caaggaagau ggcauuuc                                                     18


<210> 3382
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3382
caaggaagau ggcauuu                                                      17


<210> 3383
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3383
caaggaagau ggcauu                                                       16


<210> 3384
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3384
caaggaagau ggcau                                                        15


<210> 3385
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3385
caaggaagau ggca                                                         14


<210> 3386
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3386
caaggaagau ggc                                                          13


<210> 3387
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3387
caaggaagau gg                                                           12


<210> 3388
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3388
caaggaagau g                                                            11


<210> 3389
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3389
caaggaagau                                                              10


<210> 3390
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3390
caaggaaga                                                                9


<210> 3391
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3391
caaggaag                                                                 8


<210> 3392
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3392
aaggaagaug gcauuucuag                                                   20


<210> 3393
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3393
aaggaagaug gcauuucua                                                    19


<210> 3394
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3394
aaggaagaug gcauuucu                                                     18


<210> 3395
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3395
aaggaagaug gcauuuc                                                      17


<210> 3396
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3396
aaggaagaug gcauuu                                                       16


<210> 3397
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3397
aaggaagaug gcauu                                                        15


<210> 3398
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3398
aaggaagaug gcau                                                         14


<210> 3399
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3399
aaggaagaug gca                                                          13


<210> 3400
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3400
aaggaagaug gc                                                           12


<210> 3401
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3401
aaggaagaug g                                                            11


<210> 3402
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3402
aaggaagaug                                                              10


<210> 3403
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3403
aaggaagau                                                                9


<210> 3404
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3404
aaggaaga                                                                 8


<210> 3405
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3405
aggaagaugg cauuucuag                                                    19


<210> 3406
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3406
aggaagaugg cauuucua                                                     18


<210> 3407
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3407
aggaagaugg cauuucu                                                      17


<210> 3408
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3408
aggaagaugg cauuuc                                                       16


<210> 3409
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3409
aggaagaugg cauuu                                                        15


<210> 3410
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3410
aggaagaugg cauu                                                         14


<210> 3411
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3411
aggaagaugg cau                                                          13


<210> 3412
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3412
aggaagaugg ca                                                           12


<210> 3413
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3413
aggaagaugg                                                              10


<210> 3414
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3414
aggaagaug                                                                9


<210> 3415
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3415
aggaagau                                                                 8


<210> 3416
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3416
ggaagauggc auuucuag                                                     18


<210> 3417
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3417
ggaagauggc auuucua                                                      17


<210> 3418
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3418
ggaagauggc auuucu                                                       16


<210> 3419
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3419
ggaagauggc auuuc                                                        15


<210> 3420
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3420
ggaagauggc auuu                                                         14


<210> 3421
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3421
ggaagauggc auu                                                          13


<210> 3422
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3422
ggaagauggc au                                                           12


<210> 3423
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3423
ggaagauggc a                                                            11


<210> 3424
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3424
ggaagauggc                                                              10


<210> 3425
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3425
ggaagaug                                                                 8


<210> 3426
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3426
gaagauggca uuucuag                                                      17


<210> 3427
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3427
gaagauggca uuucua                                                       16


<210> 3428
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3428
gaagauggca uuuc                                                         14


<210> 3429
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3429
gaagauggca uuu                                                          13


<210> 3430
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3430
gaagauggca uu                                                           12


<210> 3431
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3431
gaagauggca u                                                            11


<210> 3432
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3432
gaagauggca                                                              10


<210> 3433
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3433
gaagauggc                                                                9


<210> 3434
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3434
gaagaugg                                                                 8


<210> 3435
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3435
aagauggcau uucuag                                                       16


<210> 3436
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3436
aagauggcau uucua                                                        15


<210> 3437
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3437
aagauggcau uucu                                                         14


<210> 3438
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3438
aagauggcau uuc                                                          13


<210> 3439
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3439
aagauggcau uu                                                           12


<210> 3440
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3440
aagauggcau u                                                            11


<210> 3441
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3441
aagauggcau                                                              10


<210> 3442
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3442
aagauggca                                                                9


<210> 3443
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3443
aagauggc                                                                 8


<210> 3444
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3444
agauggcauu ucuag                                                        15


<210> 3445
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3445
agauggcauu ucua                                                         14


<210> 3446
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3446
agauggcauu ucu                                                          13


<210> 3447
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3447
agauggcauu uc                                                           12


<210> 3448
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3448
agauggcauu u                                                            11


<210> 3449
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3449
agauggcauu                                                              10


<210> 3450
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3450
agauggcau                                                                9


<210> 3451
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3451
agauggca                                                                 8


<210> 3452
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3452
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 3453
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3453
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 3454
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3454
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 3455
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3455
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 3456
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3456
cuccaacauc aaggaagaug gcauuu                                            26


<210> 3457
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3457
cuccaacauc aaggaagaug gcauu                                             25


<210> 3458
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3458
cuccaacauc aaggaagaug gcau                                              24


<210> 3459
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3459
cuccaacauc aaggaagaug gca                                               23


<210> 3460
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3460
cuccaacauc aaggaagaug gc                                                22


<210> 3461
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3461
cuccaacauc aaggaagaug g                                                 21


<210> 3462
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3462
cuccaacauc aaggaagaug                                                   20


<210> 3463
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3463
cuccaacauc aaggaagau                                                    19


<210> 3464
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3464
cuccaacauc aaggaaga                                                     18


<210> 3465
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3465
cuccaacauc aaggaag                                                      17


<210> 3466
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3466
tccaacauca aggaagaugg cauuucuag                                         29


<210> 3467
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3467
tccaacauca aggaagaugg cauuucua                                          28


<210> 3468
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3468
tccaacauca aggaagaugg cauuucu                                           27


<210> 3469
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3469
tccaacauca aggaagaugg cauuuc                                            26


<210> 3470
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3470
tccaacauca aggaagaugg cauuu                                             25


<210> 3471
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3471
tccaacauca aggaagaugg cauu                                              24


<210> 3472
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3472
tccaacauca aggaagaugg cau                                               23


<210> 3473
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3473
tccaacauca aggaagaugg ca                                                22


<210> 3474
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3474
tccaacauca aggaagaugg c                                                 21


<210> 3475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3475
tccaacauca aggaagaugg                                                   20


<210> 3476
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3476
tccaacauca aggaagaug                                                    19


<210> 3477
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3477
tccaacauca aggaagau                                                     18


<210> 3478
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3478
tccaacauca aggaaga                                                      17


<210> 3479
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3479
tccaacauca aggaag                                                       16


<210> 3480
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3480
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 3481
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3481
ccaacaucaa ggaagauggc auuucua                                           27


<210> 3482
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3482
ccaacaucaa ggaagauggc auuucu                                            26


<210> 3483
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3483
ccaacaucaa ggaagauggc auuuc                                             25


<210> 3484
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3484
ccaacaucaa ggaagauggc auuu                                              24


<210> 3485
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3485
ccaacaucaa ggaagauggc auu                                               23


<210> 3486
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3486
ccaacaucaa ggaagauggc au                                                22


<210> 3487
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3487
ccaacaucaa ggaagauggc a                                                 21


<210> 3488
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3488
ccaacaucaa ggaagauggc                                                   20


<210> 3489
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3489
ccaacaucaa ggaagaugg                                                    19


<210> 3490
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3490
ccaacaucaa ggaagaug                                                     18


<210> 3491
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3491
ccaacaucaa ggaagau                                                      17


<210> 3492
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3492
ccaacaucaa ggaaga                                                       16


<210> 3493
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3493
ccaacaucaa ggaag                                                        15


<210> 3494
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3494
caacaucaag gaagauggca uuucuag                                           27


<210> 3495
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3495
caacaucaag gaagauggca uuucua                                            26


<210> 3496
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3496
caacaucaag gaagauggca uuucu                                             25


<210> 3497
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3497
caacaucaag gaagauggca uuuc                                              24


<210> 3498
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3498
caacaucaag gaagauggca uuu                                               23


<210> 3499
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3499
caacaucaag gaagauggca uu                                                22


<210> 3500
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3500
caacaucaag gaagauggca u                                                 21


<210> 3501
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3501
caacaucaag gaagauggca                                                   20


<210> 3502
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3502
caacaucaag gaagauggc                                                    19


<210> 3503
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3503
caacaucaag gaagaugg                                                     18


<210> 3504
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3504
caacaucaag gaagaug                                                      17


<210> 3505
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3505
caacaucaag gaagau                                                       16


<210> 3506
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3506
caacaucaag gaaga                                                        15


<210> 3507
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3507
caacaucaag gaag                                                         14


<210> 3508
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3508
aacaucaagg aagauggcau uucuag                                            26


<210> 3509
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3509
aacaucaagg aagauggcau uucua                                             25


<210> 3510
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3510
aacaucaagg aagauggcau uucu                                              24


<210> 3511
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3511
aacaucaagg aagauggcau uuc                                               23


<210> 3512
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3512
aacaucaagg aagauggcau uu                                                22


<210> 3513
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3513
aacaucaagg aagauggcau u                                                 21


<210> 3514
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3514
aacaucaagg aagauggcau                                                   20


<210> 3515
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3515
aacaucaagg aagauggca                                                    19


<210> 3516
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3516
aacaucaagg aagauggc                                                     18


<210> 3517
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3517
aacaucaagg aagaugg                                                      17


<210> 3518
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3518
aacaucaagg aagaug                                                       16


<210> 3519
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3519
aacaucaagg aagau                                                        15


<210> 3520
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3520
aacaucaagg aaga                                                         14


<210> 3521
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3521
aacaucaagg aag                                                          13


<210> 3522
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3522
acaucaagga agauggcauu ucuag                                             25


<210> 3523
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3523
acaucaagga agauggcauu ucua                                              24


<210> 3524
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3524
acaucaagga agauggcauu ucu                                               23


<210> 3525
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3525
acaucaagga agauggcauu uc                                                22


<210> 3526
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3526
acaucaagga agauggcauu u                                                 21


<210> 3527
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3527
acaucaagga agauggcauu                                                   20


<210> 3528
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3528
acaucaagga agauggcau                                                    19


<210> 3529
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3529
acaucaagga agauggca                                                     18


<210> 3530
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3530
acaucaagga agauggc                                                      17


<210> 3531
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3531
acaucaagga agaugg                                                       16


<210> 3532
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3532
acaucaagga agaug                                                        15


<210> 3533
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3533
acaucaagga agau                                                         14


<210> 3534
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3534
acaucaagga aga                                                          13


<210> 3535
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3535
acaucaagga ag                                                           12


<210> 3536
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3536
caucaaggaa gauggcauuu cuag                                              24


<210> 3537
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3537
caucaaggaa gauggcauuu cua                                               23


<210> 3538
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3538
caucaaggaa gauggcauuu cu                                                22


<210> 3539
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3539
caucaaggaa gauggcauuu c                                                 21


<210> 3540
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3540
caucaaggaa gauggcauuu                                                   20


<210> 3541
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3541
caucaaggaa gauggcauu                                                    19


<210> 3542
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3542
caucaaggaa gauggcau                                                     18


<210> 3543
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3543
caucaaggaa gauggca                                                      17


<210> 3544
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3544
caucaaggaa gauggc                                                       16


<210> 3545
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3545
caucaaggaa gaugg                                                        15


<210> 3546
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3546
caucaaggaa gaug                                                         14


<210> 3547
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3547
caucaaggaa gau                                                          13


<210> 3548
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3548
caucaaggaa ga                                                           12


<210> 3549
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3549
caucaaggaa g                                                            11


<210> 3550
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3550
aucaaggaag auggcauuuc uag                                               23


<210> 3551
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3551
aucaaggaag auggcauuuc ua                                                22


<210> 3552
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3552
aucaaggaag auggcauuuc u                                                 21


<210> 3553
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3553
aucaaggaag auggcauuuc                                                   20


<210> 3554
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3554
aucaaggaag auggcauuu                                                    19


<210> 3555
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3555
aucaaggaag auggcauu                                                     18


<210> 3556
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3556
aucaaggaag auggcau                                                      17


<210> 3557
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3557
aucaaggaag auggca                                                       16


<210> 3558
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3558
aucaaggaag auggc                                                        15


<210> 3559
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3559
aucaaggaag augg                                                         14


<210> 3560
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3560
aucaaggaag aug                                                          13


<210> 3561
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3561
aucaaggaag au                                                           12


<210> 3562
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3562
aucaaggaag a                                                            11


<210> 3563
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3563
aucaaggaag                                                              10


<210> 3564
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3564
ccagagcagg uaccuccaac auc                                               23


<210> 3565
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3565
ccagagcagg uaccucca                                                     18


<210> 3566
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3566
ccucugugau uuuauaacuu gau                                               23


<210> 3567
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3567
tcacccacca ucacccu                                                      17


<210> 3568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3568
tgauauccuc aaggucaccc                                                   20


<210> 3569
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3569
cugcuugaug aucaucucgu ug                                                22


<210> 3570
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3570
cugcuugaug aucaucuc                                                     18


<210> 3571
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3571
guuuccuuag uaaccacag                                                    19


<210> 3572
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3572
guuuccuuag uaaccac                                                      17


<210> 3573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3573
tcaaggaaga uggcauuucu                                                   20


<210> 3574
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3574
tcaaggaaga uggcauuucu ag                                                22


<210> 3575
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3575
gguaaguucu guccaagc                                                     18


<210> 3576
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3576
guaaguucug uccaagcc                                                     18


<210> 3577
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3577
agucgguaag uucugucc                                                     18


<210> 3578
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3578
cuguccaagc ccgguuga                                                     18


<210> 3579
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3579
taaguucugu ccaag                                                        15


<210> 3580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3580
tucuguccaa gcccgguuga                                                   20


<210> 3581
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3581
tucuguccaa gcccgguug                                                    19


<210> 3582
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3582
tucuguccaa gcccgguu                                                     18


<210> 3583
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3583
tucuguccaa gcccggu                                                      17


<210> 3584
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3584
tucuguccaa gcccgg                                                       16


<210> 3585
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3585
tucuguccaa gcccg                                                        15


<210> 3586
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3586
tucuguccaa gccc                                                         14


<210> 3587
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3587
tucuguccaa gcc                                                          13


<210> 3588
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3588
tucuguccaa gc                                                           12


<210> 3589
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3589
tucuguccaa g                                                            11


<210> 3590
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3590
tucuguccaa                                                              10


<210> 3591
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3591
tucugucca                                                                9


<210> 3592
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3592
tucugucc                                                                 8


<210> 3593
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3593
tcuguccaag cccgguuga                                                    19


<210> 3594
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3594
tcuguccaag cccgguug                                                     18


<210> 3595
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3595
tcuguccaag cccgguu                                                      17


<210> 3596
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3596
tcuguccaag cccggu                                                       16


<210> 3597
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3597
tcuguccaag cccgg                                                        15


<210> 3598
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3598
tcuguccaag cccg                                                         14


<210> 3599
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3599
tcuguccaag ccc                                                          13


<210> 3600
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3600
tcuguccaag cc                                                           12


<210> 3601
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3601
tcuguccaag c                                                            11


<210> 3602
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3602
tcuguccaag                                                              10


<210> 3603
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3603
tcuguccaa                                                                9


<210> 3604
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3604
tcugucca                                                                 8


<210> 3605
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3605
cuguccaagc ccgguug                                                      17


<210> 3606
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3606
cuguccaagc ccgguu                                                       16


<210> 3607
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3607
cuguccaagc ccggu                                                        15


<210> 3608
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3608
cuguccaagc ccgg                                                         14


<210> 3609
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3609
cuguccaagc ccg                                                          13


<210> 3610
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3610
cuguccaagc cc                                                           12


<210> 3611
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3611
cuguccaagc c                                                            11


<210> 3612
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3612
cuguccaagc                                                              10


<210> 3613
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3613
cuguccaag                                                                9


<210> 3614
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3614
cuguccaa                                                                 8


<210> 3615
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3615
guucugucca agcccgguug                                                   20


<210> 3616
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3616
guucugucca agcccgguu                                                    19


<210> 3617
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3617
guucugucca agcccggu                                                     18


<210> 3618
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3618
guucugucca agcccgg                                                      17


<210> 3619
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3619
guucugucca agcccg                                                       16


<210> 3620
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3620
guucugucca agccc                                                        15


<210> 3621
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3621
guucugucca agcc                                                         14


<210> 3622
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3622
guucugucca agc                                                          13


<210> 3623
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3623
guucugucca ag                                                           12


<210> 3624
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3624
guucugucca a                                                            11


<210> 3625
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3625
guucugucca                                                              10


<210> 3626
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3626
guucugucc                                                                9


<210> 3627
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3627
guucuguc                                                                 8


<210> 3628
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3628
aguucugucc aagcccgguu                                                   20


<210> 3629
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3629
aguucugucc aagcccggu                                                    19


<210> 3630
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3630
aguucugucc aagcccgg                                                     18


<210> 3631
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3631
aguucugucc aagcccg                                                      17


<210> 3632
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3632
aguucugucc aagccc                                                       16


<210> 3633
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3633
aguucugucc aagcc                                                        15


<210> 3634
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3634
aguucugucc aagc                                                         14


<210> 3635
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3635
aguucugucc aag                                                          13


<210> 3636
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3636
aguucugucc aa                                                           12


<210> 3637
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3637
aguucugucc a                                                            11


<210> 3638
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3638
aguucugucc                                                              10


<210> 3639
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3639
aguucuguc                                                                9


<210> 3640
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3640
aguucugu                                                                 8


<210> 3641
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3641
aaguucuguc caagcccggu                                                   20


<210> 3642
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3642
aaguucuguc caagcccgg                                                    19


<210> 3643
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3643
aaguucuguc caagcccg                                                     18


<210> 3644
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3644
aaguucuguc caagccc                                                      17


<210> 3645
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3645
aaguucuguc caagcc                                                       16


<210> 3646
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3646
aaguucuguc caagc                                                        15


<210> 3647
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3647
aaguucuguc caag                                                         14


<210> 3648
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3648
aaguucuguc caa                                                          13


<210> 3649
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3649
aaguucuguc ca                                                           12


<210> 3650
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3650
aaguucuguc c                                                            11


<210> 3651
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3651
aaguucuguc                                                              10


<210> 3652
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3652
aaguucugu                                                                9


<210> 3653
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3653
aaguucug                                                                 8


<210> 3654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3654
taaguucugu ccaagcccgg                                                   20


<210> 3655
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3655
taaguucugu ccaagcccg                                                    19


<210> 3656
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3656
taaguucugu ccaagccc                                                     18


<210> 3657
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3657
taaguucugu ccaagcc                                                      17


<210> 3658
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3658
taaguucugu ccaagc                                                       16


<210> 3659
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3659
taaguucugu ccaa                                                         14


<210> 3660
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3660
taaguucugu cca                                                          13


<210> 3661
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3661
taaguucugu cc                                                           12


<210> 3662
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3662
taaguucugu c                                                            11


<210> 3663
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3663
taaguucugu                                                              10


<210> 3664
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3664
taaguucug                                                                9


<210> 3665
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3665
taaguucu                                                                 8


<210> 3666
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3666
guaaguucug uccaagcccg                                                   20


<210> 3667
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3667
guaaguucug uccaagccc                                                    19


<210> 3668
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3668
guaaguucug uccaagc                                                      17


<210> 3669
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3669
guaaguucug uccaag                                                       16


<210> 3670
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3670
guaaguucug uccaa                                                        15


<210> 3671
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3671
guaaguucug ucca                                                         14


<210> 3672
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3672
guaaguucug ucc                                                          13


<210> 3673
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3673
guaaguucug uc                                                           12


<210> 3674
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3674
guaaguucug u                                                            11


<210> 3675
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3675
guaaguucug                                                              10


<210> 3676
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3676
guaaguucu                                                                9


<210> 3677
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3677
guaaguuc                                                                 8


<210> 3678
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3678
gguaaguucu guccaagccc                                                   20


<210> 3679
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3679
gguaaguucu guccaagcc                                                    19


<210> 3680
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3680
gguaaguucu guccaag                                                      17


<210> 3681
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3681
gguaaguucu guccaa                                                       16


<210> 3682
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3682
gguaaguucu gucca                                                        15


<210> 3683
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3683
gguaaguucu gucc                                                         14


<210> 3684
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3684
gguaaguucu guc                                                          13


<210> 3685
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3685
gguaaguucu gu                                                           12


<210> 3686
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3686
gguaaguucu g                                                            11


<210> 3687
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3687
gguaaguucu                                                              10


<210> 3688
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3688
gguaaguuc                                                                9


<210> 3689
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3689
gguaaguu                                                                 8


<210> 3690
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3690
cgguaaguuc uguccaagcc                                                   20


<210> 3691
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3691
cgguaaguuc uguccaagc                                                    19


<210> 3692
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3692
cgguaaguuc uguccaag                                                     18


<210> 3693
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3693
cgguaaguuc uguccaa                                                      17


<210> 3694
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3694
cgguaaguuc ugucca                                                       16


<210> 3695
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3695
cgguaaguuc ugucc                                                        15


<210> 3696
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3696
cgguaaguuc uguc                                                         14


<210> 3697
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3697
cgguaaguuc ugu                                                          13


<210> 3698
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3698
cgguaaguuc ug                                                           12


<210> 3699
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3699
cgguaaguuc u                                                            11


<210> 3700
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3700
cgguaaguuc                                                              10


<210> 3701
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3701
cgguaaguu                                                                9


<210> 3702
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3702
cgguaagu                                                                 8


<210> 3703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3703
tcgguaaguu cuguccaagc                                                   20


<210> 3704
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3704
tcgguaaguu cuguccaag                                                    19


<210> 3705
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3705
tcgguaaguu cuguccaa                                                     18


<210> 3706
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3706
tcgguaaguu cugucca                                                      17


<210> 3707
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3707
tcgguaaguu cugucc                                                       16


<210> 3708
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3708
tcgguaaguu cuguc                                                        15


<210> 3709
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3709
tcgguaaguu cugu                                                         14


<210> 3710
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3710
tcgguaaguu cug                                                          13


<210> 3711
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3711
tcgguaaguu cu                                                           12


<210> 3712
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3712
tcgguaaguu c                                                            11


<210> 3713
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3713
tcgguaaguu                                                              10


<210> 3714
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3714
tcgguaagu                                                                9


<210> 3715
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3715
gucgguaagu ucuguccaag                                                   20


<210> 3716
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3716
gucgguaagu ucuguccaa                                                    19


<210> 3717
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3717
gucgguaagu ucugucca                                                     18


<210> 3718
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3718
gucgguaagu ucugucc                                                      17


<210> 3719
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3719
gucgguaagu ucuguc                                                       16


<210> 3720
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3720
gucgguaagu ucugu                                                        15


<210> 3721
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3721
gucgguaagu ucug                                                         14


<210> 3722
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3722
gucgguaagu ucu                                                          13


<210> 3723
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3723
gucgguaagu uc                                                           12


<210> 3724
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3724
gucgguaagu u                                                            11


<210> 3725
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3725
gucgguaagu                                                              10


<210> 3726
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3726
agucgguaag uucuguccaa                                                   20


<210> 3727
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3727
agucgguaag uucugucca                                                    19


<210> 3728
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3728
agucgguaag uucuguc                                                      17


<210> 3729
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3729
agucgguaag uucugu                                                       16


<210> 3730
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3730
agucgguaag uucug                                                        15


<210> 3731
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3731
agucgguaag uucu                                                         14


<210> 3732
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3732
agucgguaag uuc                                                          13


<210> 3733
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3733
agucgguaag uu                                                           12


<210> 3734
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3734
agucgguaag u                                                            11


<210> 3735
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3735
cagucgguaa guucugucca                                                   20


<210> 3736
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3736
cagucgguaa guucugucc                                                    19


<210> 3737
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3737
cagucgguaa guucuguc                                                     18


<210> 3738
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3738
cagucgguaa guucugu                                                      17


<210> 3739
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3739
cagucgguaa guucug                                                       16


<210> 3740
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3740
cagucgguaa guucu                                                        15


<210> 3741
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3741
cagucgguaa guuc                                                         14


<210> 3742
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3742
cagucgguaa guu                                                          13


<210> 3743
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3743
cagucgguaa gu                                                           12


<210> 3744
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3744
ccagucggua aguucugucc                                                   20


<210> 3745
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3745
ccagucggua aguucuguc                                                    19


<210> 3746
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3746
ccagucggua aguucugu                                                     18


<210> 3747
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3747
ccagucggua aguucug                                                      17


<210> 3748
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3748
ccagucggua aguucu                                                       16


<210> 3749
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3749
ccagucggua aguuc                                                        15


<210> 3750
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3750
ccagucggua aguu                                                         14


<210> 3751
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3751
ccagucggua agu                                                          13


<210> 3752
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3752
gccagucggu aaguucuguc                                                   20


<210> 3753
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3753
gccagucggu aaguucugu                                                    19


<210> 3754
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3754
gccagucggu aaguucug                                                     18


<210> 3755
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3755
gccagucggu aaguucu                                                      17


<210> 3756
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3756
gccagucggu aaguuc                                                       16


<210> 3757
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3757
gccagucggu aaguu                                                        15


<210> 3758
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3758
gccagucggu aagu                                                         14


<210> 3759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3759
tcaaggaaga uggcauuucu                                                   20


<210> 3760
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3760
tcaaggaaga uggcauuucu ag                                                22


<210> 3761
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3761
tcaaggaaga uggcau                                                       16


<210> 3762
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3762
gaagauggca uuucu                                                        15


<210> 3763
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3763
tcaaggaaga uggcauuucu a                                                 21


<210> 3764
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3764
tcaaggaaga uggcauuuc                                                    19


<210> 3765
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3765
tcaaggaaga uggcauuu                                                     18


<210> 3766
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3766
tcaaggaaga uggcauu                                                      17


<210> 3767
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3767
tcaaggaaga uggca                                                        15


<210> 3768
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3768
tcaaggaaga uggc                                                         14


<210> 3769
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3769
tcaaggaaga ugg                                                          13


<210> 3770
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3770
tcaaggaaga ug                                                           12


<210> 3771
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3771
tcaaggaaga u                                                            11


<210> 3772
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3772
tcaaggaaga                                                              10


<210> 3773
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3773
tcaaggaag                                                                9


<210> 3774
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3774
caaggaagau ggcauuucua g                                                 21


<210> 3775
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3775
caaggaagau ggcauuucua                                                   20


<210> 3776
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3776
caaggaagau ggcauuucu                                                    19


<210> 3777
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3777
caaggaagau ggcauuuc                                                     18


<210> 3778
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3778
caaggaagau ggcauuu                                                      17


<210> 3779
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3779
caaggaagau ggcauu                                                       16


<210> 3780
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3780
caaggaagau ggcau                                                        15


<210> 3781
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3781
caaggaagau ggca                                                         14


<210> 3782
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3782
caaggaagau ggc                                                          13


<210> 3783
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3783
caaggaagau gg                                                           12


<210> 3784
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3784
caaggaagau g                                                            11


<210> 3785
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3785
caaggaagau                                                              10


<210> 3786
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3786
caaggaaga                                                                9


<210> 3787
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3787
caaggaag                                                                 8


<210> 3788
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3788
aaggaagaug gcauuucuag                                                   20


<210> 3789
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3789
aaggaagaug gcauuucua                                                    19


<210> 3790
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3790
aaggaagaug gcauuucu                                                     18


<210> 3791
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3791
aaggaagaug gcauuuc                                                      17


<210> 3792
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3792
aaggaagaug gcauuu                                                       16


<210> 3793
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3793
aaggaagaug gcauu                                                        15


<210> 3794
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3794
aaggaagaug gcau                                                         14


<210> 3795
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3795
aaggaagaug gca                                                          13


<210> 3796
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3796
aaggaagaug gc                                                           12


<210> 3797
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3797
aaggaagaug g                                                            11


<210> 3798
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3798
aaggaagaug                                                              10


<210> 3799
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3799
aaggaagau                                                                9


<210> 3800
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3800
aaggaaga                                                                 8


<210> 3801
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3801
aggaagaugg cauuucuag                                                    19


<210> 3802
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3802
aggaagaugg cauuucua                                                     18


<210> 3803
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3803
aggaagaugg cauuucu                                                      17


<210> 3804
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3804
aggaagaugg cauuuc                                                       16


<210> 3805
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3805
aggaagaugg cauuu                                                        15


<210> 3806
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3806
aggaagaugg cauu                                                         14


<210> 3807
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3807
aggaagaugg cau                                                          13


<210> 3808
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3808
aggaagaugg ca                                                           12


<210> 3809
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3809
aggaagaugg                                                              10


<210> 3810
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3810
aggaagaug                                                                9


<210> 3811
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3811
aggaagau                                                                 8


<210> 3812
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3812
ggaagauggc auuucuag                                                     18


<210> 3813
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3813
ggaagauggc auuucua                                                      17


<210> 3814
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3814
ggaagauggc auuucu                                                       16


<210> 3815
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3815
ggaagauggc auuuc                                                        15


<210> 3816
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3816
ggaagauggc auuu                                                         14


<210> 3817
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3817
ggaagauggc auu                                                          13


<210> 3818
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3818
ggaagauggc au                                                           12


<210> 3819
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3819
ggaagauggc a                                                            11


<210> 3820
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3820
ggaagauggc                                                              10


<210> 3821
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3821
ggaagaug                                                                 8


<210> 3822
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3822
gaagauggca uuucuag                                                      17


<210> 3823
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3823
gaagauggca uuucua                                                       16


<210> 3824
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3824
gaagauggca uuuc                                                         14


<210> 3825
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3825
gaagauggca uuu                                                          13


<210> 3826
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3826
gaagauggca uu                                                           12


<210> 3827
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3827
gaagauggca u                                                            11


<210> 3828
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3828
gaagauggca                                                              10


<210> 3829
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3829
gaagauggc                                                                9


<210> 3830
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3830
gaagaugg                                                                 8


<210> 3831
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3831
aagauggcau uucuag                                                       16


<210> 3832
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3832
aagauggcau uucua                                                        15


<210> 3833
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3833
aagauggcau uucu                                                         14


<210> 3834
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3834
aagauggcau uuc                                                          13


<210> 3835
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3835
aagauggcau uu                                                           12


<210> 3836
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3836
aagauggcau u                                                            11


<210> 3837
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3837
aagauggcau                                                              10


<210> 3838
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3838
aagauggca                                                                9


<210> 3839
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3839
aagauggc                                                                 8


<210> 3840
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3840
agauggcauu ucuag                                                        15


<210> 3841
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3841
agauggcauu ucua                                                         14


<210> 3842
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3842
agauggcauu ucu                                                          13


<210> 3843
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3843
agauggcauu uc                                                           12


<210> 3844
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3844
agauggcauu u                                                            11


<210> 3845
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3845
agauggcauu                                                              10


<210> 3846
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3846
agauggcau                                                                9


<210> 3847
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3847
agauggca                                                                 8


<210> 3848
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3848
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 3849
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3849
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 3850
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3850
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 3851
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3851
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 3852
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3852
cuccaacauc aaggaagaug gcauuu                                            26


<210> 3853
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3853
cuccaacauc aaggaagaug gcauu                                             25


<210> 3854
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3854
cuccaacauc aaggaagaug gcau                                              24


<210> 3855
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3855
cuccaacauc aaggaagaug gca                                               23


<210> 3856
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3856
cuccaacauc aaggaagaug gc                                                22


<210> 3857
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3857
cuccaacauc aaggaagaug g                                                 21


<210> 3858
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3858
cuccaacauc aaggaagaug                                                   20


<210> 3859
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3859
cuccaacauc aaggaagau                                                    19


<210> 3860
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3860
cuccaacauc aaggaaga                                                     18


<210> 3861
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3861
cuccaacauc aaggaag                                                      17


<210> 3862
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3862
tccaacauca aggaagaugg cauuucuag                                         29


<210> 3863
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3863
tccaacauca aggaagaugg cauuucua                                          28


<210> 3864
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3864
tccaacauca aggaagaugg cauuucu                                           27


<210> 3865
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3865
tccaacauca aggaagaugg cauuuc                                            26


<210> 3866
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3866
tccaacauca aggaagaugg cauuu                                             25


<210> 3867
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3867
tccaacauca aggaagaugg cauu                                              24


<210> 3868
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3868
tccaacauca aggaagaugg cau                                               23


<210> 3869
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3869
tccaacauca aggaagaugg ca                                                22


<210> 3870
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3870
tccaacauca aggaagaugg c                                                 21


<210> 3871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3871
tccaacauca aggaagaugg                                                   20


<210> 3872
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3872
tccaacauca aggaagaug                                                    19


<210> 3873
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3873
tccaacauca aggaagau                                                     18


<210> 3874
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3874
tccaacauca aggaaga                                                      17


<210> 3875
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3875
tccaacauca aggaag                                                       16


<210> 3876
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3876
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 3877
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3877
ccaacaucaa ggaagauggc auuucua                                           27


<210> 3878
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3878
ccaacaucaa ggaagauggc auuucu                                            26


<210> 3879
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3879
ccaacaucaa ggaagauggc auuuc                                             25


<210> 3880
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3880
ccaacaucaa ggaagauggc auuu                                              24


<210> 3881
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3881
ccaacaucaa ggaagauggc auu                                               23


<210> 3882
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3882
ccaacaucaa ggaagauggc au                                                22


<210> 3883
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3883
ccaacaucaa ggaagauggc a                                                 21


<210> 3884
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3884
ccaacaucaa ggaagauggc                                                   20


<210> 3885
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3885
ccaacaucaa ggaagaugg                                                    19


<210> 3886
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3886
ccaacaucaa ggaagaug                                                     18


<210> 3887
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3887
ccaacaucaa ggaagau                                                      17


<210> 3888
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3888
ccaacaucaa ggaaga                                                       16


<210> 3889
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3889
ccaacaucaa ggaag                                                        15


<210> 3890
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3890
caacaucaag gaagauggca uuucuag                                           27


<210> 3891
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3891
caacaucaag gaagauggca uuucua                                            26


<210> 3892
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3892
caacaucaag gaagauggca uuucu                                             25


<210> 3893
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3893
caacaucaag gaagauggca uuuc                                              24


<210> 3894
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3894
caacaucaag gaagauggca uuu                                               23


<210> 3895
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3895
caacaucaag gaagauggca uu                                                22


<210> 3896
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3896
caacaucaag gaagauggca u                                                 21


<210> 3897
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3897
caacaucaag gaagauggca                                                   20


<210> 3898
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3898
caacaucaag gaagauggc                                                    19


<210> 3899
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3899
caacaucaag gaagaugg                                                     18


<210> 3900
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3900
caacaucaag gaagaug                                                      17


<210> 3901
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3901
caacaucaag gaagau                                                       16


<210> 3902
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3902
caacaucaag gaaga                                                        15


<210> 3903
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3903
caacaucaag gaag                                                         14


<210> 3904
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3904
aacaucaagg aagauggcau uucuag                                            26


<210> 3905
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3905
aacaucaagg aagauggcau uucua                                             25


<210> 3906
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3906
aacaucaagg aagauggcau uucu                                              24


<210> 3907
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3907
aacaucaagg aagauggcau uuc                                               23


<210> 3908
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3908
aacaucaagg aagauggcau uu                                                22


<210> 3909
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3909
aacaucaagg aagauggcau u                                                 21


<210> 3910
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3910
aacaucaagg aagauggcau                                                   20


<210> 3911
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3911
aacaucaagg aagauggca                                                    19


<210> 3912
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3912
aacaucaagg aagauggc                                                     18


<210> 3913
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3913
aacaucaagg aagaugg                                                      17


<210> 3914
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3914
aacaucaagg aagaug                                                       16


<210> 3915
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3915
aacaucaagg aagau                                                        15


<210> 3916
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3916
aacaucaagg aaga                                                         14


<210> 3917
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3917
aacaucaagg aag                                                          13


<210> 3918
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3918
acaucaagga agauggcauu ucuag                                             25


<210> 3919
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3919
acaucaagga agauggcauu ucua                                              24


<210> 3920
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3920
acaucaagga agauggcauu ucu                                               23


<210> 3921
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3921
acaucaagga agauggcauu uc                                                22


<210> 3922
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3922
acaucaagga agauggcauu u                                                 21


<210> 3923
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3923
acaucaagga agauggcauu                                                   20


<210> 3924
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3924
acaucaagga agauggcau                                                    19


<210> 3925
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3925
acaucaagga agauggca                                                     18


<210> 3926
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3926
acaucaagga agauggc                                                      17


<210> 3927
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3927
acaucaagga agaugg                                                       16


<210> 3928
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3928
acaucaagga agaug                                                        15


<210> 3929
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3929
acaucaagga agau                                                         14


<210> 3930
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3930
acaucaagga aga                                                          13


<210> 3931
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3931
acaucaagga ag                                                           12


<210> 3932
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3932
caucaaggaa gauggcauuu cuag                                              24


<210> 3933
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3933
caucaaggaa gauggcauuu cua                                               23


<210> 3934
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3934
caucaaggaa gauggcauuu cu                                                22


<210> 3935
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3935
caucaaggaa gauggcauuu c                                                 21


<210> 3936
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3936
caucaaggaa gauggcauuu                                                   20


<210> 3937
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3937
caucaaggaa gauggcauu                                                    19


<210> 3938
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3938
caucaaggaa gauggcau                                                     18


<210> 3939
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3939
caucaaggaa gauggca                                                      17


<210> 3940
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3940
caucaaggaa gauggc                                                       16


<210> 3941
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3941
caucaaggaa gaugg                                                        15


<210> 3942
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3942
caucaaggaa gaug                                                         14


<210> 3943
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3943
caucaaggaa gau                                                          13


<210> 3944
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3944
caucaaggaa ga                                                           12


<210> 3945
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3945
caucaaggaa g                                                            11


<210> 3946
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3946
aucaaggaag auggcauuuc uag                                               23


<210> 3947
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3947
aucaaggaag auggcauuuc ua                                                22


<210> 3948
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3948
aucaaggaag auggcauuuc u                                                 21


<210> 3949
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3949
aucaaggaag auggcauuuc                                                   20


<210> 3950
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3950
aucaaggaag auggcauuu                                                    19


<210> 3951
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3951
aucaaggaag auggcauu                                                     18


<210> 3952
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3952
aucaaggaag auggcau                                                      17


<210> 3953
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3953
aucaaggaag auggca                                                       16


<210> 3954
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3954
aucaaggaag auggc                                                        15


<210> 3955
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3955
aucaaggaag augg                                                         14


<210> 3956
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3956
aucaaggaag aug                                                          13


<210> 3957
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3957
aucaaggaag au                                                           12


<210> 3958
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3958
aucaaggaag a                                                            11


<210> 3959
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3959
aucaaggaag                                                              10


<210> 3960
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3960
ccagagcagg uaccuccaac auc                                               23


<210> 3961
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3961
ccagagcagg uaccucca                                                     18


<210> 3962
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3962
ccucugugau uuuauaacuu gau                                               23


<210> 3963
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3963
tcacccacca ucacccu                                                      17


<210> 3964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3964
tgauauccuc aaggucaccc                                                   20


<210> 3965
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3965
cugcuugaug aucaucucgu ug                                                22


<210> 3966
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3966
cugcuugaug aucaucuc                                                     18


<210> 3967
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3967
guuuccuuag uaaccacag                                                    19


<210> 3968
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 3968
guuuccuuag uaaccac                                                      17


<210> 3969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3969
tcaaggaaga uggcauuucu                                                   20


<210> 3970
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3970
tcaaggaaga uggcauuucu ag                                                22


<210> 3971
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3971
gguaaguucu guccaagc                                                     18


<210> 3972
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3972
guaaguucug uccaagcc                                                     18


<210> 3973
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3973
agucgguaag uucugucc                                                     18


<210> 3974
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3974
cuguccaagc ccgguuga                                                     18


<210> 3975
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3975
taaguucugu ccaag                                                        15


<210> 3976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3976
tucuguccaa gcccgguuga                                                   20


<210> 3977
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3977
tucuguccaa gcccgguug                                                    19


<210> 3978
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3978
tucuguccaa gcccgguu                                                     18


<210> 3979
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3979
tucuguccaa gcccggu                                                      17


<210> 3980
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3980
tucuguccaa gcccgg                                                       16


<210> 3981
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3981
tucuguccaa gcccg                                                        15


<210> 3982
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3982
tucuguccaa gccc                                                         14


<210> 3983
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3983
tucuguccaa gcc                                                          13


<210> 3984
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3984
tucuguccaa gc                                                           12


<210> 3985
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3985
tucuguccaa g                                                            11


<210> 3986
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3986
tucuguccaa                                                              10


<210> 3987
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3987
tucugucca                                                                9


<210> 3988
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3988
tucugucc                                                                 8


<210> 3989
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3989
tcuguccaag cccgguuga                                                    19


<210> 3990
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3990
tcuguccaag cccgguug                                                     18


<210> 3991
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3991
tcuguccaag cccgguu                                                      17


<210> 3992
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3992
tcuguccaag cccggu                                                       16


<210> 3993
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3993
tcuguccaag cccgg                                                        15


<210> 3994
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3994
tcuguccaag cccg                                                         14


<210> 3995
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3995
tcuguccaag ccc                                                          13


<210> 3996
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3996
tcuguccaag cc                                                           12


<210> 3997
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3997
tcuguccaag c                                                            11


<210> 3998
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3998
tcuguccaag                                                              10


<210> 3999
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 3999
tcuguccaa                                                                9


<210> 4000
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4000
tcugucca                                                                 8


<210> 4001
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4001
cuguccaagc ccgguug                                                      17


<210> 4002
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4002
cuguccaagc ccgguu                                                       16


<210> 4003
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4003
cuguccaagc ccggu                                                        15


<210> 4004
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4004
cuguccaagc ccgg                                                         14


<210> 4005
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4005
cuguccaagc ccg                                                          13


<210> 4006
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4006
cuguccaagc cc                                                           12


<210> 4007
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4007
cuguccaagc c                                                            11


<210> 4008
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4008
cuguccaagc                                                              10


<210> 4009
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4009
cuguccaag                                                                9


<210> 4010
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4010
cuguccaa                                                                 8


<210> 4011
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4011
guucugucca agcccgguug                                                   20


<210> 4012
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4012
guucugucca agcccgguu                                                    19


<210> 4013
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4013
guucugucca agcccggu                                                     18


<210> 4014
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4014
guucugucca agcccgg                                                      17


<210> 4015
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4015
guucugucca agcccg                                                       16


<210> 4016
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4016
guucugucca agccc                                                        15


<210> 4017
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4017
guucugucca agcc                                                         14


<210> 4018
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4018
guucugucca agc                                                          13


<210> 4019
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4019
guucugucca ag                                                           12


<210> 4020
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4020
guucugucca a                                                            11


<210> 4021
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4021
guucugucca                                                              10


<210> 4022
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4022
guucugucc                                                                9


<210> 4023
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4023
guucuguc                                                                 8


<210> 4024
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4024
aguucugucc aagcccgguu                                                   20


<210> 4025
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4025
aguucugucc aagcccggu                                                    19


<210> 4026
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4026
aguucugucc aagcccgg                                                     18


<210> 4027
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4027
aguucugucc aagcccg                                                      17


<210> 4028
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4028
aguucugucc aagccc                                                       16


<210> 4029
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4029
aguucugucc aagcc                                                        15


<210> 4030
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4030
aguucugucc aagc                                                         14


<210> 4031
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4031
aguucugucc aag                                                          13


<210> 4032
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4032
aguucugucc aa                                                           12


<210> 4033
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4033
aguucugucc a                                                            11


<210> 4034
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4034
aguucugucc                                                              10


<210> 4035
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4035
aguucuguc                                                                9


<210> 4036
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4036
aguucugu                                                                 8


<210> 4037
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4037
aaguucuguc caagcccggu                                                   20


<210> 4038
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4038
aaguucuguc caagcccgg                                                    19


<210> 4039
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4039
aaguucuguc caagcccg                                                     18


<210> 4040
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4040
aaguucuguc caagccc                                                      17


<210> 4041
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4041
aaguucuguc caagcc                                                       16


<210> 4042
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4042
aaguucuguc caagc                                                        15


<210> 4043
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4043
aaguucuguc caag                                                         14


<210> 4044
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4044
aaguucuguc caa                                                          13


<210> 4045
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4045
aaguucuguc ca                                                           12


<210> 4046
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4046
aaguucuguc c                                                            11


<210> 4047
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4047
aaguucuguc                                                              10


<210> 4048
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4048
aaguucugu                                                                9


<210> 4049
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4049
aaguucug                                                                 8


<210> 4050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4050
taaguucugu ccaagcccgg                                                   20


<210> 4051
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4051
taaguucugu ccaagcccg                                                    19


<210> 4052
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4052
taaguucugu ccaagccc                                                     18


<210> 4053
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4053
taaguucugu ccaagcc                                                      17


<210> 4054
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4054
taaguucugu ccaagc                                                       16


<210> 4055
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4055
taaguucugu ccaa                                                         14


<210> 4056
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4056
taaguucugu cca                                                          13


<210> 4057
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4057
taaguucugu cc                                                           12


<210> 4058
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4058
taaguucugu c                                                            11


<210> 4059
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4059
taaguucugu                                                              10


<210> 4060
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4060
taaguucug                                                                9


<210> 4061
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4061
taaguucu                                                                 8


<210> 4062
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4062
guaaguucug uccaagcccg                                                   20


<210> 4063
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4063
guaaguucug uccaagccc                                                    19


<210> 4064
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4064
guaaguucug uccaagc                                                      17


<210> 4065
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4065
guaaguucug uccaag                                                       16


<210> 4066
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4066
guaaguucug uccaa                                                        15


<210> 4067
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4067
guaaguucug ucca                                                         14


<210> 4068
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4068
guaaguucug ucc                                                          13


<210> 4069
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4069
guaaguucug uc                                                           12


<210> 4070
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4070
guaaguucug u                                                            11


<210> 4071
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4071
guaaguucug                                                              10


<210> 4072
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4072
guaaguucu                                                                9


<210> 4073
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4073
guaaguuc                                                                 8


<210> 4074
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4074
gguaaguucu guccaagccc                                                   20


<210> 4075
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4075
gguaaguucu guccaagcc                                                    19


<210> 4076
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4076
gguaaguucu guccaag                                                      17


<210> 4077
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4077
gguaaguucu guccaa                                                       16


<210> 4078
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4078
gguaaguucu gucca                                                        15


<210> 4079
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4079
gguaaguucu gucc                                                         14


<210> 4080
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4080
gguaaguucu guc                                                          13


<210> 4081
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4081
gguaaguucu gu                                                           12


<210> 4082
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4082
gguaaguucu g                                                            11


<210> 4083
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4083
gguaaguucu                                                              10


<210> 4084
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4084
gguaaguuc                                                                9


<210> 4085
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4085
gguaaguu                                                                 8


<210> 4086
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4086
cgguaaguuc uguccaagcc                                                   20


<210> 4087
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4087
cgguaaguuc uguccaagc                                                    19


<210> 4088
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4088
cgguaaguuc uguccaag                                                     18


<210> 4089
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4089
cgguaaguuc uguccaa                                                      17


<210> 4090
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4090
cgguaaguuc ugucca                                                       16


<210> 4091
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4091
cgguaaguuc ugucc                                                        15


<210> 4092
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4092
cgguaaguuc uguc                                                         14


<210> 4093
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4093
cgguaaguuc ugu                                                          13


<210> 4094
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4094
cgguaaguuc ug                                                           12


<210> 4095
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4095
cgguaaguuc u                                                            11


<210> 4096
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4096
cgguaaguuc                                                              10


<210> 4097
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4097
cgguaaguu                                                                9


<210> 4098
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4098
cgguaagu                                                                 8


<210> 4099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4099
tcgguaaguu cuguccaagc                                                   20


<210> 4100
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4100
tcgguaaguu cuguccaag                                                    19


<210> 4101
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4101
tcgguaaguu cuguccaa                                                     18


<210> 4102
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4102
tcgguaaguu cugucca                                                      17


<210> 4103
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4103
tcgguaaguu cugucc                                                       16


<210> 4104
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4104
tcgguaaguu cuguc                                                        15


<210> 4105
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4105
tcgguaaguu cugu                                                         14


<210> 4106
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4106
tcgguaaguu cug                                                          13


<210> 4107
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4107
tcgguaaguu cu                                                           12


<210> 4108
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4108
tcgguaaguu c                                                            11


<210> 4109
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4109
tcgguaaguu                                                              10


<210> 4110
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4110
tcgguaagu                                                                9


<210> 4111
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4111
gucgguaagu ucuguccaag                                                   20


<210> 4112
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4112
gucgguaagu ucuguccaa                                                    19


<210> 4113
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4113
gucgguaagu ucugucca                                                     18


<210> 4114
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4114
gucgguaagu ucugucc                                                      17


<210> 4115
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4115
gucgguaagu ucuguc                                                       16


<210> 4116
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4116
gucgguaagu ucugu                                                        15


<210> 4117
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4117
gucgguaagu ucug                                                         14


<210> 4118
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4118
gucgguaagu ucu                                                          13


<210> 4119
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4119
gucgguaagu uc                                                           12


<210> 4120
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4120
gucgguaagu u                                                            11


<210> 4121
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4121
gucgguaagu                                                              10


<210> 4122
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4122
agucgguaag uucuguccaa                                                   20


<210> 4123
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4123
agucgguaag uucugucca                                                    19


<210> 4124
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4124
agucgguaag uucuguc                                                      17


<210> 4125
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4125
agucgguaag uucugu                                                       16


<210> 4126
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4126
agucgguaag uucug                                                        15


<210> 4127
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4127
agucgguaag uucu                                                         14


<210> 4128
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4128
agucgguaag uuc                                                          13


<210> 4129
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4129
agucgguaag uu                                                           12


<210> 4130
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4130
agucgguaag u                                                            11


<210> 4131
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4131
cagucgguaa guucugucca                                                   20


<210> 4132
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4132
cagucgguaa guucugucc                                                    19


<210> 4133
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4133
cagucgguaa guucuguc                                                     18


<210> 4134
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4134
cagucgguaa guucugu                                                      17


<210> 4135
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4135
cagucgguaa guucug                                                       16


<210> 4136
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4136
cagucgguaa guucu                                                        15


<210> 4137
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4137
cagucgguaa guuc                                                         14


<210> 4138
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4138
cagucgguaa guu                                                          13


<210> 4139
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4139
cagucgguaa gu                                                           12


<210> 4140
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4140
ccagucggua aguucugucc                                                   20


<210> 4141
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4141
ccagucggua aguucuguc                                                    19


<210> 4142
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4142
ccagucggua aguucugu                                                     18


<210> 4143
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4143
ccagucggua aguucug                                                      17


<210> 4144
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4144
ccagucggua aguucu                                                       16


<210> 4145
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4145
ccagucggua aguuc                                                        15


<210> 4146
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4146
ccagucggua aguu                                                         14


<210> 4147
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4147
ccagucggua agu                                                          13


<210> 4148
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4148
gccagucggu aaguucuguc                                                   20


<210> 4149
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4149
gccagucggu aaguucugu                                                    19


<210> 4150
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4150
gccagucggu aaguucug                                                     18


<210> 4151
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4151
gccagucggu aaguucu                                                      17


<210> 4152
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4152
gccagucggu aaguuc                                                       16


<210> 4153
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4153
gccagucggu aaguu                                                        15


<210> 4154
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4154
gccagucggu aagu                                                         14


<210> 4155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4155
tcaaggaaga uggcauuucu                                                   20


<210> 4156
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4156
tcaaggaaga uggcauuucu ag                                                22


<210> 4157
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4157
tcaaggaaga uggcau                                                       16


<210> 4158
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4158
gaagauggca uuucu                                                        15


<210> 4159
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4159
tcaaggaaga uggcauuucu a                                                 21


<210> 4160
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4160
tcaaggaaga uggcauuuc                                                    19


<210> 4161
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4161
tcaaggaaga uggcauuu                                                     18


<210> 4162
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4162
tcaaggaaga uggcauu                                                      17


<210> 4163
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4163
tcaaggaaga uggca                                                        15


<210> 4164
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4164
tcaaggaaga uggc                                                         14


<210> 4165
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4165
tcaaggaaga ugg                                                          13


<210> 4166
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4166
tcaaggaaga ug                                                           12


<210> 4167
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4167
tcaaggaaga u                                                            11


<210> 4168
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4168
tcaaggaaga                                                              10


<210> 4169
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4169
tcaaggaag                                                                9


<210> 4170
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4170
caaggaagau ggcauuucua g                                                 21


<210> 4171
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4171
caaggaagau ggcauuucua                                                   20


<210> 4172
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4172
caaggaagau ggcauuucu                                                    19


<210> 4173
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4173
caaggaagau ggcauuuc                                                     18


<210> 4174
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4174
caaggaagau ggcauuu                                                      17


<210> 4175
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4175
caaggaagau ggcauu                                                       16


<210> 4176
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4176
caaggaagau ggcau                                                        15


<210> 4177
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4177
caaggaagau ggca                                                         14


<210> 4178
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4178
caaggaagau ggc                                                          13


<210> 4179
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4179
caaggaagau gg                                                           12


<210> 4180
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4180
caaggaagau g                                                            11


<210> 4181
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4181
caaggaagau                                                              10


<210> 4182
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4182
caaggaaga                                                                9


<210> 4183
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4183
caaggaag                                                                 8


<210> 4184
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4184
aaggaagaug gcauuucuag                                                   20


<210> 4185
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4185
aaggaagaug gcauuucua                                                    19


<210> 4186
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4186
aaggaagaug gcauuucu                                                     18


<210> 4187
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4187
aaggaagaug gcauuuc                                                      17


<210> 4188
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4188
aaggaagaug gcauuu                                                       16


<210> 4189
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4189
aaggaagaug gcauu                                                        15


<210> 4190
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4190
aaggaagaug gcau                                                         14


<210> 4191
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4191
aaggaagaug gca                                                          13


<210> 4192
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4192
aaggaagaug gc                                                           12


<210> 4193
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4193
aaggaagaug g                                                            11


<210> 4194
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4194
aaggaagaug                                                              10


<210> 4195
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4195
aaggaagau                                                                9


<210> 4196
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4196
aaggaaga                                                                 8


<210> 4197
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4197
aggaagaugg cauuucuag                                                    19


<210> 4198
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4198
aggaagaugg cauuucua                                                     18


<210> 4199
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4199
aggaagaugg cauuucu                                                      17


<210> 4200
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4200
aggaagaugg cauuuc                                                       16


<210> 4201
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4201
aggaagaugg cauuu                                                        15


<210> 4202
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4202
aggaagaugg cauu                                                         14


<210> 4203
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4203
aggaagaugg cau                                                          13


<210> 4204
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4204
aggaagaugg ca                                                           12


<210> 4205
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4205
aggaagaugg                                                              10


<210> 4206
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4206
aggaagaug                                                                9


<210> 4207
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4207
aggaagau                                                                 8


<210> 4208
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4208
ggaagauggc auuucuag                                                     18


<210> 4209
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4209
ggaagauggc auuucua                                                      17


<210> 4210
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4210
ggaagauggc auuucu                                                       16


<210> 4211
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4211
ggaagauggc auuuc                                                        15


<210> 4212
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4212
ggaagauggc auuu                                                         14


<210> 4213
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4213
ggaagauggc auu                                                          13


<210> 4214
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4214
ggaagauggc au                                                           12


<210> 4215
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4215
ggaagauggc a                                                            11


<210> 4216
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4216
ggaagauggc                                                              10


<210> 4217
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4217
ggaagaug                                                                 8


<210> 4218
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4218
gaagauggca uuucuag                                                      17


<210> 4219
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4219
gaagauggca uuucua                                                       16


<210> 4220
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4220
gaagauggca uuuc                                                         14


<210> 4221
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4221
gaagauggca uuu                                                          13


<210> 4222
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4222
gaagauggca uu                                                           12


<210> 4223
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4223
gaagauggca u                                                            11


<210> 4224
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4224
gaagauggca                                                              10


<210> 4225
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4225
gaagauggc                                                                9


<210> 4226
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4226
gaagaugg                                                                 8


<210> 4227
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4227
aagauggcau uucuag                                                       16


<210> 4228
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4228
aagauggcau uucua                                                        15


<210> 4229
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4229
aagauggcau uucu                                                         14


<210> 4230
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4230
aagauggcau uuc                                                          13


<210> 4231
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4231
aagauggcau uu                                                           12


<210> 4232
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4232
aagauggcau u                                                            11


<210> 4233
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4233
aagauggcau                                                              10


<210> 4234
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4234
aagauggca                                                                9


<210> 4235
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4235
aagauggc                                                                 8


<210> 4236
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4236
agauggcauu ucuag                                                        15


<210> 4237
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4237
agauggcauu ucua                                                         14


<210> 4238
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4238
agauggcauu ucu                                                          13


<210> 4239
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4239
agauggcauu uc                                                           12


<210> 4240
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4240
agauggcauu u                                                            11


<210> 4241
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4241
agauggcauu                                                              10


<210> 4242
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4242
agauggcau                                                                9


<210> 4243
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4243
agauggca                                                                 8


<210> 4244
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4244
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 4245
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4245
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 4246
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4246
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 4247
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4247
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 4248
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4248
cuccaacauc aaggaagaug gcauuu                                            26


<210> 4249
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4249
cuccaacauc aaggaagaug gcauu                                             25


<210> 4250
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4250
cuccaacauc aaggaagaug gcau                                              24


<210> 4251
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4251
cuccaacauc aaggaagaug gca                                               23


<210> 4252
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4252
cuccaacauc aaggaagaug gc                                                22


<210> 4253
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4253
cuccaacauc aaggaagaug g                                                 21


<210> 4254
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4254
cuccaacauc aaggaagaug                                                   20


<210> 4255
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4255
cuccaacauc aaggaagau                                                    19


<210> 4256
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4256
cuccaacauc aaggaaga                                                     18


<210> 4257
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4257
cuccaacauc aaggaag                                                      17


<210> 4258
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4258
tccaacauca aggaagaugg cauuucuag                                         29


<210> 4259
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4259
tccaacauca aggaagaugg cauuucua                                          28


<210> 4260
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4260
tccaacauca aggaagaugg cauuucu                                           27


<210> 4261
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4261
tccaacauca aggaagaugg cauuuc                                            26


<210> 4262
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4262
tccaacauca aggaagaugg cauuu                                             25


<210> 4263
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4263
tccaacauca aggaagaugg cauu                                              24


<210> 4264
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4264
tccaacauca aggaagaugg cau                                               23


<210> 4265
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4265
tccaacauca aggaagaugg ca                                                22


<210> 4266
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4266
tccaacauca aggaagaugg c                                                 21


<210> 4267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4267
tccaacauca aggaagaugg                                                   20


<210> 4268
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4268
tccaacauca aggaagaug                                                    19


<210> 4269
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4269
tccaacauca aggaagau                                                     18


<210> 4270
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4270
tccaacauca aggaaga                                                      17


<210> 4271
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4271
tccaacauca aggaag                                                       16


<210> 4272
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4272
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 4273
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4273
ccaacaucaa ggaagauggc auuucua                                           27


<210> 4274
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4274
ccaacaucaa ggaagauggc auuucu                                            26


<210> 4275
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4275
ccaacaucaa ggaagauggc auuuc                                             25


<210> 4276
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4276
ccaacaucaa ggaagauggc auuu                                              24


<210> 4277
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4277
ccaacaucaa ggaagauggc auu                                               23


<210> 4278
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4278
ccaacaucaa ggaagauggc au                                                22


<210> 4279
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4279
ccaacaucaa ggaagauggc a                                                 21


<210> 4280
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4280
ccaacaucaa ggaagauggc                                                   20


<210> 4281
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4281
ccaacaucaa ggaagaugg                                                    19


<210> 4282
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4282
ccaacaucaa ggaagaug                                                     18


<210> 4283
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4283
ccaacaucaa ggaagau                                                      17


<210> 4284
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4284
ccaacaucaa ggaaga                                                       16


<210> 4285
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4285
ccaacaucaa ggaag                                                        15


<210> 4286
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4286
caacaucaag gaagauggca uuucuag                                           27


<210> 4287
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4287
caacaucaag gaagauggca uuucua                                            26


<210> 4288
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4288
caacaucaag gaagauggca uuucu                                             25


<210> 4289
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4289
caacaucaag gaagauggca uuuc                                              24


<210> 4290
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4290
caacaucaag gaagauggca uuu                                               23


<210> 4291
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4291
caacaucaag gaagauggca uu                                                22


<210> 4292
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4292
caacaucaag gaagauggca u                                                 21


<210> 4293
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4293
caacaucaag gaagauggca                                                   20


<210> 4294
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4294
caacaucaag gaagauggc                                                    19


<210> 4295
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4295
caacaucaag gaagaugg                                                     18


<210> 4296
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4296
caacaucaag gaagaug                                                      17


<210> 4297
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4297
caacaucaag gaagau                                                       16


<210> 4298
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4298
caacaucaag gaaga                                                        15


<210> 4299
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4299
caacaucaag gaag                                                         14


<210> 4300
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4300
aacaucaagg aagauggcau uucuag                                            26


<210> 4301
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4301
aacaucaagg aagauggcau uucua                                             25


<210> 4302
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4302
aacaucaagg aagauggcau uucu                                              24


<210> 4303
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4303
aacaucaagg aagauggcau uuc                                               23


<210> 4304
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4304
aacaucaagg aagauggcau uu                                                22


<210> 4305
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4305
aacaucaagg aagauggcau u                                                 21


<210> 4306
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4306
aacaucaagg aagauggcau                                                   20


<210> 4307
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4307
aacaucaagg aagauggca                                                    19


<210> 4308
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4308
aacaucaagg aagauggc                                                     18


<210> 4309
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4309
aacaucaagg aagaugg                                                      17


<210> 4310
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4310
aacaucaagg aagaug                                                       16


<210> 4311
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4311
aacaucaagg aagau                                                        15


<210> 4312
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4312
aacaucaagg aaga                                                         14


<210> 4313
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4313
aacaucaagg aag                                                          13


<210> 4314
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4314
acaucaagga agauggcauu ucuag                                             25


<210> 4315
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4315
acaucaagga agauggcauu ucua                                              24


<210> 4316
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4316
acaucaagga agauggcauu ucu                                               23


<210> 4317
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4317
acaucaagga agauggcauu uc                                                22


<210> 4318
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4318
acaucaagga agauggcauu u                                                 21


<210> 4319
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4319
acaucaagga agauggcauu                                                   20


<210> 4320
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4320
acaucaagga agauggcau                                                    19


<210> 4321
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4321
acaucaagga agauggca                                                     18


<210> 4322
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4322
acaucaagga agauggc                                                      17


<210> 4323
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4323
acaucaagga agaugg                                                       16


<210> 4324
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4324
acaucaagga agaug                                                        15


<210> 4325
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4325
acaucaagga agau                                                         14


<210> 4326
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4326
acaucaagga aga                                                          13


<210> 4327
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4327
acaucaagga ag                                                           12


<210> 4328
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4328
caucaaggaa gauggcauuu cuag                                              24


<210> 4329
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4329
caucaaggaa gauggcauuu cua                                               23


<210> 4330
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4330
caucaaggaa gauggcauuu cu                                                22


<210> 4331
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4331
caucaaggaa gauggcauuu c                                                 21


<210> 4332
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4332
caucaaggaa gauggcauuu                                                   20


<210> 4333
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4333
caucaaggaa gauggcauu                                                    19


<210> 4334
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4334
caucaaggaa gauggcau                                                     18


<210> 4335
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4335
caucaaggaa gauggca                                                      17


<210> 4336
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4336
caucaaggaa gauggc                                                       16


<210> 4337
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4337
caucaaggaa gaugg                                                        15


<210> 4338
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4338
caucaaggaa gaug                                                         14


<210> 4339
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4339
caucaaggaa gau                                                          13


<210> 4340
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4340
caucaaggaa ga                                                           12


<210> 4341
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4341
caucaaggaa g                                                            11


<210> 4342
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4342
aucaaggaag auggcauuuc uag                                               23


<210> 4343
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4343
aucaaggaag auggcauuuc ua                                                22


<210> 4344
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4344
aucaaggaag auggcauuuc u                                                 21


<210> 4345
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4345
aucaaggaag auggcauuuc                                                   20


<210> 4346
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4346
aucaaggaag auggcauuu                                                    19


<210> 4347
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4347
aucaaggaag auggcauu                                                     18


<210> 4348
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4348
aucaaggaag auggcau                                                      17


<210> 4349
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4349
aucaaggaag auggca                                                       16


<210> 4350
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4350
aucaaggaag auggc                                                        15


<210> 4351
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4351
aucaaggaag augg                                                         14


<210> 4352
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4352
aucaaggaag aug                                                          13


<210> 4353
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4353
aucaaggaag au                                                           12


<210> 4354
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4354
aucaaggaag a                                                            11


<210> 4355
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4355
aucaaggaag                                                              10


<210> 4356
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4356
ccagagcagg uaccuccaac auc                                               23


<210> 4357
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4357
ccagagcagg uaccucca                                                     18


<210> 4358
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4358
ccucugugau uuuauaacuu gau                                               23


<210> 4359
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4359
tcacccacca ucacccu                                                      17


<210> 4360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4360
tgauauccuc aaggucaccc                                                   20


<210> 4361
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4361
cugcuugaug aucaucucgu ug                                                22


<210> 4362
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4362
cugcuugaug aucaucuc                                                     18


<210> 4363
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4363
guuuccuuag uaaccacag                                                    19


<210> 4364
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4364
guuuccuuag uaaccac                                                      17


<210> 4365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4365
tcaaggaaga uggcauuucu                                                   20


<210> 4366
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4366
tcaaggaaga uggcauuucu ag                                                22


<210> 4367
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4367
gguaaguucu guccaagc                                                     18


<210> 4368
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4368
guaaguucug uccaagcc                                                     18


<210> 4369
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4369
agucgguaag uucugucc                                                     18


<210> 4370
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4370
cuguccaagc ccgguuga                                                     18


<210> 4371
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4371
taaguucugu ccaag                                                        15


<210> 4372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4372
tucuguccaa gcccgguuga                                                   20


<210> 4373
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4373
tucuguccaa gcccgguug                                                    19


<210> 4374
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4374
tucuguccaa gcccgguu                                                     18


<210> 4375
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4375
tucuguccaa gcccggu                                                      17


<210> 4376
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4376
tucuguccaa gcccgg                                                       16


<210> 4377
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4377
tucuguccaa gcccg                                                        15


<210> 4378
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4378
tucuguccaa gccc                                                         14


<210> 4379
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4379
tucuguccaa gcc                                                          13


<210> 4380
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4380
tucuguccaa gc                                                           12


<210> 4381
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4381
tucuguccaa g                                                            11


<210> 4382
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4382
tucuguccaa                                                              10


<210> 4383
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4383
tucugucca                                                                9


<210> 4384
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4384
tucugucc                                                                 8


<210> 4385
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4385
tcuguccaag cccgguuga                                                    19


<210> 4386
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4386
tcuguccaag cccgguug                                                     18


<210> 4387
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4387
tcuguccaag cccgguu                                                      17


<210> 4388
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4388
tcuguccaag cccggu                                                       16


<210> 4389
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4389
tcuguccaag cccgg                                                        15


<210> 4390
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4390
tcuguccaag cccg                                                         14


<210> 4391
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4391
tcuguccaag ccc                                                          13


<210> 4392
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4392
tcuguccaag cc                                                           12


<210> 4393
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4393
tcuguccaag c                                                            11


<210> 4394
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4394
tcuguccaag                                                              10


<210> 4395
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4395
tcuguccaa                                                                9


<210> 4396
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4396
tcugucca                                                                 8


<210> 4397
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4397
cuguccaagc ccgguug                                                      17


<210> 4398
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4398
cuguccaagc ccgguu                                                       16


<210> 4399
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4399
cuguccaagc ccggu                                                        15


<210> 4400
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4400
cuguccaagc ccgg                                                         14


<210> 4401
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4401
cuguccaagc ccg                                                          13


<210> 4402
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4402
cuguccaagc cc                                                           12


<210> 4403
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4403
cuguccaagc c                                                            11


<210> 4404
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4404
cuguccaagc                                                              10


<210> 4405
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4405
cuguccaag                                                                9


<210> 4406
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4406
cuguccaa                                                                 8


<210> 4407
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4407
guucugucca agcccgguug                                                   20


<210> 4408
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4408
guucugucca agcccgguu                                                    19


<210> 4409
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4409
guucugucca agcccggu                                                     18


<210> 4410
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4410
guucugucca agcccgg                                                      17


<210> 4411
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4411
guucugucca agcccg                                                       16


<210> 4412
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4412
guucugucca agccc                                                        15


<210> 4413
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4413
guucugucca agcc                                                         14


<210> 4414
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4414
guucugucca agc                                                          13


<210> 4415
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4415
guucugucca ag                                                           12


<210> 4416
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4416
guucugucca a                                                            11


<210> 4417
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4417
guucugucca                                                              10


<210> 4418
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4418
guucugucc                                                                9


<210> 4419
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4419
guucuguc                                                                 8


<210> 4420
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4420
aguucugucc aagcccgguu                                                   20


<210> 4421
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4421
aguucugucc aagcccggu                                                    19


<210> 4422
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4422
aguucugucc aagcccgg                                                     18


<210> 4423
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4423
aguucugucc aagcccg                                                      17


<210> 4424
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4424
aguucugucc aagccc                                                       16


<210> 4425
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4425
aguucugucc aagcc                                                        15


<210> 4426
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4426
aguucugucc aagc                                                         14


<210> 4427
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4427
aguucugucc aag                                                          13


<210> 4428
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4428
aguucugucc aa                                                           12


<210> 4429
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4429
aguucugucc a                                                            11


<210> 4430
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4430
aguucugucc                                                              10


<210> 4431
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4431
aguucuguc                                                                9


<210> 4432
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4432
aguucugu                                                                 8


<210> 4433
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4433
aaguucuguc caagcccggu                                                   20


<210> 4434
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4434
aaguucuguc caagcccgg                                                    19


<210> 4435
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4435
aaguucuguc caagcccg                                                     18


<210> 4436
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4436
aaguucuguc caagccc                                                      17


<210> 4437
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4437
aaguucuguc caagcc                                                       16


<210> 4438
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4438
aaguucuguc caagc                                                        15


<210> 4439
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4439
aaguucuguc caag                                                         14


<210> 4440
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4440
aaguucuguc caa                                                          13


<210> 4441
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4441
aaguucuguc ca                                                           12


<210> 4442
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4442
aaguucuguc c                                                            11


<210> 4443
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4443
aaguucuguc                                                              10


<210> 4444
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4444
aaguucugu                                                                9


<210> 4445
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4445
aaguucug                                                                 8


<210> 4446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4446
taaguucugu ccaagcccgg                                                   20


<210> 4447
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4447
taaguucugu ccaagcccg                                                    19


<210> 4448
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4448
taaguucugu ccaagccc                                                     18


<210> 4449
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4449
taaguucugu ccaagcc                                                      17


<210> 4450
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4450
taaguucugu ccaagc                                                       16


<210> 4451
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4451
taaguucugu ccaa                                                         14


<210> 4452
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4452
taaguucugu cca                                                          13


<210> 4453
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4453
taaguucugu cc                                                           12


<210> 4454
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4454
taaguucugu c                                                            11


<210> 4455
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4455
taaguucugu                                                              10


<210> 4456
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4456
taaguucug                                                                9


<210> 4457
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4457
taaguucu                                                                 8


<210> 4458
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4458
guaaguucug uccaagcccg                                                   20


<210> 4459
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4459
guaaguucug uccaagccc                                                    19


<210> 4460
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4460
guaaguucug uccaagc                                                      17


<210> 4461
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4461
guaaguucug uccaag                                                       16


<210> 4462
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4462
guaaguucug uccaa                                                        15


<210> 4463
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4463
guaaguucug ucca                                                         14


<210> 4464
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4464
guaaguucug ucc                                                          13


<210> 4465
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4465
guaaguucug uc                                                           12


<210> 4466
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4466
guaaguucug u                                                            11


<210> 4467
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4467
guaaguucug                                                              10


<210> 4468
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4468
guaaguucu                                                                9


<210> 4469
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4469
guaaguuc                                                                 8


<210> 4470
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4470
gguaaguucu guccaagccc                                                   20


<210> 4471
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4471
gguaaguucu guccaagcc                                                    19


<210> 4472
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4472
gguaaguucu guccaag                                                      17


<210> 4473
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4473
gguaaguucu guccaa                                                       16


<210> 4474
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4474
gguaaguucu gucca                                                        15


<210> 4475
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4475
gguaaguucu gucc                                                         14


<210> 4476
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4476
gguaaguucu guc                                                          13


<210> 4477
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4477
gguaaguucu gu                                                           12


<210> 4478
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4478
gguaaguucu g                                                            11


<210> 4479
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4479
gguaaguucu                                                              10


<210> 4480
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4480
gguaaguuc                                                                9


<210> 4481
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4481
gguaaguu                                                                 8


<210> 4482
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4482
cgguaaguuc uguccaagcc                                                   20


<210> 4483
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4483
cgguaaguuc uguccaagc                                                    19


<210> 4484
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4484
cgguaaguuc uguccaag                                                     18


<210> 4485
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4485
cgguaaguuc uguccaa                                                      17


<210> 4486
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4486
cgguaaguuc ugucca                                                       16


<210> 4487
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4487
cgguaaguuc ugucc                                                        15


<210> 4488
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4488
cgguaaguuc uguc                                                         14


<210> 4489
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4489
cgguaaguuc ugu                                                          13


<210> 4490
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4490
cgguaaguuc ug                                                           12


<210> 4491
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4491
cgguaaguuc u                                                            11


<210> 4492
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4492
cgguaaguuc                                                              10


<210> 4493
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4493
cgguaaguu                                                                9


<210> 4494
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4494
cgguaagu                                                                 8


<210> 4495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4495
tcgguaaguu cuguccaagc                                                   20


<210> 4496
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4496
tcgguaaguu cuguccaag                                                    19


<210> 4497
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4497
tcgguaaguu cuguccaa                                                     18


<210> 4498
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4498
tcgguaaguu cugucca                                                      17


<210> 4499
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4499
tcgguaaguu cugucc                                                       16


<210> 4500
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4500
tcgguaaguu cuguc                                                        15


<210> 4501
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4501
tcgguaaguu cugu                                                         14


<210> 4502
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4502
tcgguaaguu cug                                                          13


<210> 4503
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4503
tcgguaaguu cu                                                           12


<210> 4504
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4504
tcgguaaguu c                                                            11


<210> 4505
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4505
tcgguaaguu                                                              10


<210> 4506
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4506
tcgguaagu                                                                9


<210> 4507
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4507
gucgguaagu ucuguccaag                                                   20


<210> 4508
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4508
gucgguaagu ucuguccaa                                                    19


<210> 4509
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4509
gucgguaagu ucugucca                                                     18


<210> 4510
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4510
gucgguaagu ucugucc                                                      17


<210> 4511
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4511
gucgguaagu ucuguc                                                       16


<210> 4512
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4512
gucgguaagu ucugu                                                        15


<210> 4513
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4513
gucgguaagu ucug                                                         14


<210> 4514
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4514
gucgguaagu ucu                                                          13


<210> 4515
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4515
gucgguaagu uc                                                           12


<210> 4516
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4516
gucgguaagu u                                                            11


<210> 4517
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4517
gucgguaagu                                                              10


<210> 4518
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4518
agucgguaag uucuguccaa                                                   20


<210> 4519
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4519
agucgguaag uucugucca                                                    19


<210> 4520
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4520
agucgguaag uucuguc                                                      17


<210> 4521
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4521
agucgguaag uucugu                                                       16


<210> 4522
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4522
agucgguaag uucug                                                        15


<210> 4523
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4523
agucgguaag uucu                                                         14


<210> 4524
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4524
agucgguaag uuc                                                          13


<210> 4525
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4525
agucgguaag uu                                                           12


<210> 4526
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4526
agucgguaag u                                                            11


<210> 4527
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4527
cagucgguaa guucugucca                                                   20


<210> 4528
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4528
cagucgguaa guucugucc                                                    19


<210> 4529
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4529
cagucgguaa guucuguc                                                     18


<210> 4530
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4530
cagucgguaa guucugu                                                      17


<210> 4531
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4531
cagucgguaa guucug                                                       16


<210> 4532
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4532
cagucgguaa guucu                                                        15


<210> 4533
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4533
cagucgguaa guuc                                                         14


<210> 4534
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4534
cagucgguaa guu                                                          13


<210> 4535
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4535
cagucgguaa gu                                                           12


<210> 4536
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4536
ccagucggua aguucugucc                                                   20


<210> 4537
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4537
ccagucggua aguucuguc                                                    19


<210> 4538
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4538
ccagucggua aguucugu                                                     18


<210> 4539
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4539
ccagucggua aguucug                                                      17


<210> 4540
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4540
ccagucggua aguucu                                                       16


<210> 4541
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4541
ccagucggua aguuc                                                        15


<210> 4542
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4542
ccagucggua aguu                                                         14


<210> 4543
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4543
ccagucggua agu                                                          13


<210> 4544
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4544
gccagucggu aaguucuguc                                                   20


<210> 4545
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4545
gccagucggu aaguucugu                                                    19


<210> 4546
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4546
gccagucggu aaguucug                                                     18


<210> 4547
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4547
gccagucggu aaguucu                                                      17


<210> 4548
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4548
gccagucggu aaguuc                                                       16


<210> 4549
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4549
gccagucggu aaguu                                                        15


<210> 4550
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4550
gccagucggu aagu                                                         14


<210> 4551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4551
tcaaggaaga uggcauuucu                                                   20


<210> 4552
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4552
tcaaggaaga uggcauuucu ag                                                22


<210> 4553
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4553
tcaaggaaga uggcau                                                       16


<210> 4554
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4554
gaagauggca uuucu                                                        15


<210> 4555
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4555
tcaaggaaga uggcauuucu a                                                 21


<210> 4556
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4556
tcaaggaaga uggcauuuc                                                    19


<210> 4557
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4557
tcaaggaaga uggcauuu                                                     18


<210> 4558
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4558
tcaaggaaga uggcauu                                                      17


<210> 4559
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4559
tcaaggaaga uggca                                                        15


<210> 4560
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4560
tcaaggaaga uggc                                                         14


<210> 4561
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4561
tcaaggaaga ugg                                                          13


<210> 4562
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4562
tcaaggaaga ug                                                           12


<210> 4563
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4563
tcaaggaaga u                                                            11


<210> 4564
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4564
tcaaggaaga                                                              10


<210> 4565
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4565
tcaaggaag                                                                9


<210> 4566
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4566
caaggaagau ggcauuucua g                                                 21


<210> 4567
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4567
caaggaagau ggcauuucua                                                   20


<210> 4568
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4568
caaggaagau ggcauuucu                                                    19


<210> 4569
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4569
caaggaagau ggcauuuc                                                     18


<210> 4570
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4570
caaggaagau ggcauuu                                                      17


<210> 4571
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4571
caaggaagau ggcauu                                                       16


<210> 4572
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4572
caaggaagau ggcau                                                        15


<210> 4573
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4573
caaggaagau ggca                                                         14


<210> 4574
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4574
caaggaagau ggc                                                          13


<210> 4575
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4575
caaggaagau gg                                                           12


<210> 4576
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4576
caaggaagau g                                                            11


<210> 4577
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4577
caaggaagau                                                              10


<210> 4578
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4578
caaggaaga                                                                9


<210> 4579
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4579
caaggaag                                                                 8


<210> 4580
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4580
aaggaagaug gcauuucuag                                                   20


<210> 4581
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4581
aaggaagaug gcauuucua                                                    19


<210> 4582
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4582
aaggaagaug gcauuucu                                                     18


<210> 4583
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4583
aaggaagaug gcauuuc                                                      17


<210> 4584
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4584
aaggaagaug gcauuu                                                       16


<210> 4585
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4585
aaggaagaug gcauu                                                        15


<210> 4586
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4586
aaggaagaug gcau                                                         14


<210> 4587
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4587
aaggaagaug gca                                                          13


<210> 4588
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4588
aaggaagaug gc                                                           12


<210> 4589
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4589
aaggaagaug g                                                            11


<210> 4590
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4590
aaggaagaug                                                              10


<210> 4591
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4591
aaggaagau                                                                9


<210> 4592
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4592
aaggaaga                                                                 8


<210> 4593
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4593
aggaagaugg cauuucuag                                                    19


<210> 4594
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4594
aggaagaugg cauuucua                                                     18


<210> 4595
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4595
aggaagaugg cauuucu                                                      17


<210> 4596
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4596
aggaagaugg cauuuc                                                       16


<210> 4597
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4597
aggaagaugg cauuu                                                        15


<210> 4598
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4598
aggaagaugg cauu                                                         14


<210> 4599
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4599
aggaagaugg cau                                                          13


<210> 4600
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4600
aggaagaugg ca                                                           12


<210> 4601
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4601
aggaagaugg                                                              10


<210> 4602
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4602
aggaagaug                                                                9


<210> 4603
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4603
aggaagau                                                                 8


<210> 4604
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4604
ggaagauggc auuucuag                                                     18


<210> 4605
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4605
ggaagauggc auuucua                                                      17


<210> 4606
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4606
ggaagauggc auuucu                                                       16


<210> 4607
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4607
ggaagauggc auuuc                                                        15


<210> 4608
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4608
ggaagauggc auuu                                                         14


<210> 4609
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4609
ggaagauggc auu                                                          13


<210> 4610
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4610
ggaagauggc au                                                           12


<210> 4611
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4611
ggaagauggc a                                                            11


<210> 4612
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4612
ggaagauggc                                                              10


<210> 4613
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4613
ggaagaug                                                                 8


<210> 4614
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4614
gaagauggca uuucuag                                                      17


<210> 4615
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4615
gaagauggca uuucua                                                       16


<210> 4616
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4616
gaagauggca uuuc                                                         14


<210> 4617
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4617
gaagauggca uuu                                                          13


<210> 4618
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4618
gaagauggca uu                                                           12


<210> 4619
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4619
gaagauggca u                                                            11


<210> 4620
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4620
gaagauggca                                                              10


<210> 4621
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4621
gaagauggc                                                                9


<210> 4622
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4622
gaagaugg                                                                 8


<210> 4623
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4623
aagauggcau uucuag                                                       16


<210> 4624
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4624
aagauggcau uucua                                                        15


<210> 4625
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4625
aagauggcau uucu                                                         14


<210> 4626
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4626
aagauggcau uuc                                                          13


<210> 4627
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4627
aagauggcau uu                                                           12


<210> 4628
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4628
aagauggcau u                                                            11


<210> 4629
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4629
aagauggcau                                                              10


<210> 4630
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4630
aagauggca                                                                9


<210> 4631
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4631
aagauggc                                                                 8


<210> 4632
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4632
agauggcauu ucuag                                                        15


<210> 4633
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4633
agauggcauu ucua                                                         14


<210> 4634
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4634
agauggcauu ucu                                                          13


<210> 4635
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4635
agauggcauu uc                                                           12


<210> 4636
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4636
agauggcauu u                                                            11


<210> 4637
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4637
agauggcauu                                                              10


<210> 4638
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4638
agauggcau                                                                9


<210> 4639
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4639
agauggca                                                                 8


<210> 4640
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4640
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 4641
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4641
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 4642
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4642
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 4643
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4643
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 4644
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4644
cuccaacauc aaggaagaug gcauuu                                            26


<210> 4645
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4645
cuccaacauc aaggaagaug gcauu                                             25


<210> 4646
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4646
cuccaacauc aaggaagaug gcau                                              24


<210> 4647
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4647
cuccaacauc aaggaagaug gca                                               23


<210> 4648
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4648
cuccaacauc aaggaagaug gc                                                22


<210> 4649
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4649
cuccaacauc aaggaagaug g                                                 21


<210> 4650
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4650
cuccaacauc aaggaagaug                                                   20


<210> 4651
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4651
cuccaacauc aaggaagau                                                    19


<210> 4652
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4652
cuccaacauc aaggaaga                                                     18


<210> 4653
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4653
cuccaacauc aaggaag                                                      17


<210> 4654
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4654
tccaacauca aggaagaugg cauuucuag                                         29


<210> 4655
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4655
tccaacauca aggaagaugg cauuucua                                          28


<210> 4656
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4656
tccaacauca aggaagaugg cauuucu                                           27


<210> 4657
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4657
tccaacauca aggaagaugg cauuuc                                            26


<210> 4658
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4658
tccaacauca aggaagaugg cauuu                                             25


<210> 4659
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4659
tccaacauca aggaagaugg cauu                                              24


<210> 4660
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4660
tccaacauca aggaagaugg cau                                               23


<210> 4661
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4661
tccaacauca aggaagaugg ca                                                22


<210> 4662
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4662
tccaacauca aggaagaugg c                                                 21


<210> 4663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4663
tccaacauca aggaagaugg                                                   20


<210> 4664
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4664
tccaacauca aggaagaug                                                    19


<210> 4665
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4665
tccaacauca aggaagau                                                     18


<210> 4666
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4666
tccaacauca aggaaga                                                      17


<210> 4667
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4667
tccaacauca aggaag                                                       16


<210> 4668
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4668
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 4669
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4669
ccaacaucaa ggaagauggc auuucua                                           27


<210> 4670
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4670
ccaacaucaa ggaagauggc auuucu                                            26


<210> 4671
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4671
ccaacaucaa ggaagauggc auuuc                                             25


<210> 4672
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4672
ccaacaucaa ggaagauggc auuu                                              24


<210> 4673
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4673
ccaacaucaa ggaagauggc auu                                               23


<210> 4674
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4674
ccaacaucaa ggaagauggc au                                                22


<210> 4675
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4675
ccaacaucaa ggaagauggc a                                                 21


<210> 4676
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4676
ccaacaucaa ggaagauggc                                                   20


<210> 4677
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4677
ccaacaucaa ggaagaugg                                                    19


<210> 4678
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4678
ccaacaucaa ggaagaug                                                     18


<210> 4679
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4679
ccaacaucaa ggaagau                                                      17


<210> 4680
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4680
ccaacaucaa ggaaga                                                       16


<210> 4681
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4681
ccaacaucaa ggaag                                                        15


<210> 4682
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4682
caacaucaag gaagauggca uuucuag                                           27


<210> 4683
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4683
caacaucaag gaagauggca uuucua                                            26


<210> 4684
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4684
caacaucaag gaagauggca uuucu                                             25


<210> 4685
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4685
caacaucaag gaagauggca uuuc                                              24


<210> 4686
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4686
caacaucaag gaagauggca uuu                                               23


<210> 4687
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4687
caacaucaag gaagauggca uu                                                22


<210> 4688
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4688
caacaucaag gaagauggca u                                                 21


<210> 4689
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4689
caacaucaag gaagauggca                                                   20


<210> 4690
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4690
caacaucaag gaagauggc                                                    19


<210> 4691
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4691
caacaucaag gaagaugg                                                     18


<210> 4692
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4692
caacaucaag gaagaug                                                      17


<210> 4693
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4693
caacaucaag gaagau                                                       16


<210> 4694
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4694
caacaucaag gaaga                                                        15


<210> 4695
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4695
caacaucaag gaag                                                         14


<210> 4696
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4696
aacaucaagg aagauggcau uucuag                                            26


<210> 4697
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4697
aacaucaagg aagauggcau uucua                                             25


<210> 4698
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4698
aacaucaagg aagauggcau uucu                                              24


<210> 4699
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4699
aacaucaagg aagauggcau uuc                                               23


<210> 4700
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4700
aacaucaagg aagauggcau uu                                                22


<210> 4701
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4701
aacaucaagg aagauggcau u                                                 21


<210> 4702
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4702
aacaucaagg aagauggcau                                                   20


<210> 4703
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4703
aacaucaagg aagauggca                                                    19


<210> 4704
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4704
aacaucaagg aagauggc                                                     18


<210> 4705
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4705
aacaucaagg aagaugg                                                      17


<210> 4706
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4706
aacaucaagg aagaug                                                       16


<210> 4707
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4707
aacaucaagg aagau                                                        15


<210> 4708
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4708
aacaucaagg aaga                                                         14


<210> 4709
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4709
aacaucaagg aag                                                          13


<210> 4710
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4710
acaucaagga agauggcauu ucuag                                             25


<210> 4711
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4711
acaucaagga agauggcauu ucua                                              24


<210> 4712
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4712
acaucaagga agauggcauu ucu                                               23


<210> 4713
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4713
acaucaagga agauggcauu uc                                                22


<210> 4714
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4714
acaucaagga agauggcauu u                                                 21


<210> 4715
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4715
acaucaagga agauggcauu                                                   20


<210> 4716
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4716
acaucaagga agauggcau                                                    19


<210> 4717
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4717
acaucaagga agauggca                                                     18


<210> 4718
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4718
acaucaagga agauggc                                                      17


<210> 4719
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4719
acaucaagga agaugg                                                       16


<210> 4720
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4720
acaucaagga agaug                                                        15


<210> 4721
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4721
acaucaagga agau                                                         14


<210> 4722
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4722
acaucaagga aga                                                          13


<210> 4723
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4723
acaucaagga ag                                                           12


<210> 4724
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4724
caucaaggaa gauggcauuu cuag                                              24


<210> 4725
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4725
caucaaggaa gauggcauuu cua                                               23


<210> 4726
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4726
caucaaggaa gauggcauuu cu                                                22


<210> 4727
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4727
caucaaggaa gauggcauuu c                                                 21


<210> 4728
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4728
caucaaggaa gauggcauuu                                                   20


<210> 4729
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4729
caucaaggaa gauggcauu                                                    19


<210> 4730
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4730
caucaaggaa gauggcau                                                     18


<210> 4731
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4731
caucaaggaa gauggca                                                      17


<210> 4732
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4732
caucaaggaa gauggc                                                       16


<210> 4733
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4733
caucaaggaa gaugg                                                        15


<210> 4734
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4734
caucaaggaa gaug                                                         14


<210> 4735
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4735
caucaaggaa gau                                                          13


<210> 4736
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4736
caucaaggaa ga                                                           12


<210> 4737
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4737
caucaaggaa g                                                            11


<210> 4738
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4738
aucaaggaag auggcauuuc uag                                               23


<210> 4739
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4739
aucaaggaag auggcauuuc ua                                                22


<210> 4740
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4740
aucaaggaag auggcauuuc u                                                 21


<210> 4741
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4741
aucaaggaag auggcauuuc                                                   20


<210> 4742
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4742
aucaaggaag auggcauuu                                                    19


<210> 4743
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4743
aucaaggaag auggcauu                                                     18


<210> 4744
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4744
aucaaggaag auggcau                                                      17


<210> 4745
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4745
aucaaggaag auggca                                                       16


<210> 4746
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4746
aucaaggaag auggc                                                        15


<210> 4747
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4747
aucaaggaag augg                                                         14


<210> 4748
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4748
aucaaggaag aug                                                          13


<210> 4749
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4749
aucaaggaag au                                                           12


<210> 4750
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4750
aucaaggaag a                                                            11


<210> 4751
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4751
aucaaggaag                                                              10


<210> 4752
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4752
ccagagcagg uaccuccaac auc                                               23


<210> 4753
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4753
ccagagcagg uaccucca                                                     18


<210> 4754
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4754
ccucugugau uuuauaacuu gau                                               23


<210> 4755
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4755
tcacccacca ucacccu                                                      17


<210> 4756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4756
tgauauccuc aaggucaccc                                                   20


<210> 4757
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4757
cugcuugaug aucaucucgu ug                                                22


<210> 4758
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4758
cugcuugaug aucaucuc                                                     18


<210> 4759
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4759
guuuccuuag uaaccacag                                                    19


<210> 4760
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 4760
guuuccuuag uaaccac                                                      17


<210> 4761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4761
ucaaggaaga uggcauuuct                                                   20


<210> 4762
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 4762
ucaaggaaga uggcauuucu ag                                                22


<210> 4763
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4763
gguaaguucu guccaagc                                                     18


<210> 4764
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4764
guaaguucug uccaagcc                                                     18


<210> 4765
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4765
agucgguaag uucugucc                                                     18


<210> 4766
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4766
cuguccaagc ccgguuga                                                     18


<210> 4767
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4767
uaaguucugu ccaag                                                        15


<210> 4768
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4768
uucuguccaa gcccgguuga                                                   20


<210> 4769
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4769
uucuguccaa gcccgguug                                                    19


<210> 4770
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4770
uucuguccaa gcccggut                                                     18


<210> 4771
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4771
uucuguccaa gcccggt                                                      17


<210> 4772
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4772
uucuguccaa gcccgg                                                       16


<210> 4773
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4773
uucuguccaa gcccg                                                        15


<210> 4774
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4774
uucuguccaa gccc                                                         14


<210> 4775
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4775
uucuguccaa gcc                                                          13


<210> 4776
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4776
uucuguccaa gc                                                           12


<210> 4777
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4777
uucuguccaa g                                                            11


<210> 4778
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4778
uucuguccaa                                                              10


<210> 4779
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4779
uucugucca                                                                9


<210> 4780
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4780
uucugucc                                                                 8


<210> 4781
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4781
ucuguccaag cccgguuga                                                    19


<210> 4782
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4782
ucuguccaag cccgguug                                                     18


<210> 4783
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4783
ucuguccaag cccggut                                                      17


<210> 4784
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4784
ucuguccaag cccggt                                                       16


<210> 4785
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4785
ucuguccaag cccgg                                                        15


<210> 4786
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4786
ucuguccaag cccg                                                         14


<210> 4787
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4787
ucuguccaag ccc                                                          13


<210> 4788
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4788
ucuguccaag cc                                                           12


<210> 4789
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4789
ucuguccaag c                                                            11


<210> 4790
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4790
ucuguccaag                                                              10


<210> 4791
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4791
ucuguccaa                                                                9


<210> 4792
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4792
ucugucca                                                                 8


<210> 4793
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4793
cuguccaagc ccgguug                                                      17


<210> 4794
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4794
cuguccaagc ccggut                                                       16


<210> 4795
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4795
cuguccaagc ccggt                                                        15


<210> 4796
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4796
cuguccaagc ccgg                                                         14


<210> 4797
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4797
cuguccaagc ccg                                                          13


<210> 4798
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4798
cuguccaagc cc                                                           12


<210> 4799
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4799
cuguccaagc c                                                            11


<210> 4800
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4800
cuguccaagc                                                              10


<210> 4801
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4801
cuguccaag                                                                9


<210> 4802
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4802
cuguccaa                                                                 8


<210> 4803
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4803
guucugucca agcccgguug                                                   20


<210> 4804
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4804
guucugucca agcccggut                                                    19


<210> 4805
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4805
guucugucca agcccggt                                                     18


<210> 4806
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4806
guucugucca agcccgg                                                      17


<210> 4807
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4807
guucugucca agcccg                                                       16


<210> 4808
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4808
guucugucca agccc                                                        15


<210> 4809
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4809
guucugucca agcc                                                         14


<210> 4810
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4810
guucugucca agc                                                          13


<210> 4811
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4811
guucugucca ag                                                           12


<210> 4812
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4812
guucugucca a                                                            11


<210> 4813
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4813
guucugucca                                                              10


<210> 4814
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4814
guucugucc                                                                9


<210> 4815
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4815
guucuguc                                                                 8


<210> 4816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4816
aguucugucc aagcccggut                                                   20


<210> 4817
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4817
aguucugucc aagcccggt                                                    19


<210> 4818
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4818
aguucugucc aagcccgg                                                     18


<210> 4819
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4819
aguucugucc aagcccg                                                      17


<210> 4820
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4820
aguucugucc aagccc                                                       16


<210> 4821
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4821
aguucugucc aagcc                                                        15


<210> 4822
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4822
aguucugucc aagc                                                         14


<210> 4823
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4823
aguucugucc aag                                                          13


<210> 4824
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4824
aguucugucc aa                                                           12


<210> 4825
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4825
aguucugucc a                                                            11


<210> 4826
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4826
aguucugucc                                                              10


<210> 4827
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4827
aguucuguc                                                                9


<210> 4828
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4828
aguucugt                                                                 8


<210> 4829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4829
aaguucuguc caagcccggt                                                   20


<210> 4830
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4830
aaguucuguc caagcccgg                                                    19


<210> 4831
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4831
aaguucuguc caagcccg                                                     18


<210> 4832
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4832
aaguucuguc caagccc                                                      17


<210> 4833
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4833
aaguucuguc caagcc                                                       16


<210> 4834
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4834
aaguucuguc caagc                                                        15


<210> 4835
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4835
aaguucuguc caag                                                         14


<210> 4836
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4836
aaguucuguc caa                                                          13


<210> 4837
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4837
aaguucuguc ca                                                           12


<210> 4838
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4838
aaguucuguc c                                                            11


<210> 4839
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4839
aaguucuguc                                                              10


<210> 4840
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4840
aaguucugt                                                                9


<210> 4841
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4841
aaguucug                                                                 8


<210> 4842
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4842
uaaguucugu ccaagcccgg                                                   20


<210> 4843
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4843
uaaguucugu ccaagcccg                                                    19


<210> 4844
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4844
uaaguucugu ccaagccc                                                     18


<210> 4845
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4845
uaaguucugu ccaagcc                                                      17


<210> 4846
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4846
uaaguucugu ccaagc                                                       16


<210> 4847
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4847
uaaguucugu ccaa                                                         14


<210> 4848
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4848
uaaguucugu cca                                                          13


<210> 4849
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4849
uaaguucugu cc                                                           12


<210> 4850
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4850
uaaguucugu c                                                            11


<210> 4851
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4851
uaaguucugt                                                              10


<210> 4852
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4852
uaaguucug                                                                9


<210> 4853
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4853
uaaguuct                                                                 8


<210> 4854
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4854
guaaguucug uccaagcccg                                                   20


<210> 4855
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4855
guaaguucug uccaagccc                                                    19


<210> 4856
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4856
guaaguucug uccaagc                                                      17


<210> 4857
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4857
guaaguucug uccaag                                                       16


<210> 4858
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4858
guaaguucug uccaa                                                        15


<210> 4859
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4859
guaaguucug ucca                                                         14


<210> 4860
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4860
guaaguucug ucc                                                          13


<210> 4861
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4861
guaaguucug uc                                                           12


<210> 4862
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4862
guaaguucug t                                                            11


<210> 4863
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4863
guaaguucug                                                              10


<210> 4864
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4864
guaaguuct                                                                9


<210> 4865
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4865
guaaguuc                                                                 8


<210> 4866
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4866
gguaaguucu guccaagccc                                                   20


<210> 4867
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4867
gguaaguucu guccaagcc                                                    19


<210> 4868
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4868
gguaaguucu guccaag                                                      17


<210> 4869
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4869
gguaaguucu guccaa                                                       16


<210> 4870
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4870
gguaaguucu gucca                                                        15


<210> 4871
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4871
gguaaguucu gucc                                                         14


<210> 4872
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4872
gguaaguucu guc                                                          13


<210> 4873
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4873
gguaaguucu gt                                                           12


<210> 4874
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4874
gguaaguucu g                                                            11


<210> 4875
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4875
gguaaguuct                                                              10


<210> 4876
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4876
gguaaguuc                                                                9


<210> 4877
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4877
gguaagut                                                                 8


<210> 4878
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4878
cgguaaguuc uguccaagcc                                                   20


<210> 4879
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4879
cgguaaguuc uguccaagc                                                    19


<210> 4880
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4880
cgguaaguuc uguccaag                                                     18


<210> 4881
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4881
cgguaaguuc uguccaa                                                      17


<210> 4882
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4882
cgguaaguuc ugucca                                                       16


<210> 4883
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4883
cgguaaguuc ugucc                                                        15


<210> 4884
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4884
cgguaaguuc uguc                                                         14


<210> 4885
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4885
cgguaaguuc ugt                                                          13


<210> 4886
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4886
cgguaaguuc ug                                                           12


<210> 4887
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4887
cgguaaguuc t                                                            11


<210> 4888
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4888
cgguaaguuc                                                              10


<210> 4889
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4889
cgguaagut                                                                9


<210> 4890
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4890
cgguaagt                                                                 8


<210> 4891
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4891
ucgguaaguu cuguccaagc                                                   20


<210> 4892
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4892
ucgguaaguu cuguccaag                                                    19


<210> 4893
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4893
ucgguaaguu cuguccaa                                                     18


<210> 4894
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4894
ucgguaaguu cugucca                                                      17


<210> 4895
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4895
ucgguaaguu cugucc                                                       16


<210> 4896
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4896
ucgguaaguu cuguc                                                        15


<210> 4897
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4897
ucgguaaguu cugt                                                         14


<210> 4898
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4898
ucgguaaguu cug                                                          13


<210> 4899
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4899
ucgguaaguu ct                                                           12


<210> 4900
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4900
ucgguaaguu c                                                            11


<210> 4901
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4901
ucgguaagut                                                              10


<210> 4902
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4902
ucgguaagt                                                                9


<210> 4903
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4903
gucgguaagu ucuguccaag                                                   20


<210> 4904
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4904
gucgguaagu ucuguccaa                                                    19


<210> 4905
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4905
gucgguaagu ucugucca                                                     18


<210> 4906
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4906
gucgguaagu ucugucc                                                      17


<210> 4907
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4907
gucgguaagu ucuguc                                                       16


<210> 4908
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4908
gucgguaagu ucugt                                                        15


<210> 4909
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4909
gucgguaagu ucug                                                         14


<210> 4910
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4910
gucgguaagu uct                                                          13


<210> 4911
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4911
gucgguaagu uc                                                           12


<210> 4912
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4912
gucgguaagu t                                                            11


<210> 4913
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4913
gucgguaagt                                                              10


<210> 4914
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4914
agucgguaag uucuguccaa                                                   20


<210> 4915
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4915
agucgguaag uucugucca                                                    19


<210> 4916
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4916
agucgguaag uucuguc                                                      17


<210> 4917
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4917
agucgguaag uucugt                                                       16


<210> 4918
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4918
agucgguaag uucug                                                        15


<210> 4919
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4919
agucgguaag uuct                                                         14


<210> 4920
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4920
agucgguaag uuc                                                          13


<210> 4921
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4921
agucgguaag ut                                                           12


<210> 4922
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4922
agucgguaag t                                                            11


<210> 4923
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4923
cagucgguaa guucugucca                                                   20


<210> 4924
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4924
cagucgguaa guucugucc                                                    19


<210> 4925
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4925
cagucgguaa guucuguc                                                     18


<210> 4926
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4926
cagucgguaa guucugt                                                      17


<210> 4927
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4927
cagucgguaa guucug                                                       16


<210> 4928
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4928
cagucgguaa guuct                                                        15


<210> 4929
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4929
cagucgguaa guuc                                                         14


<210> 4930
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4930
cagucgguaa gut                                                          13


<210> 4931
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4931
cagucgguaa gt                                                           12


<210> 4932
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4932
ccagucggua aguucugucc                                                   20


<210> 4933
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4933
ccagucggua aguucuguc                                                    19


<210> 4934
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4934
ccagucggua aguucugt                                                     18


<210> 4935
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4935
ccagucggua aguucug                                                      17


<210> 4936
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4936
ccagucggua aguuct                                                       16


<210> 4937
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4937
ccagucggua aguuc                                                        15


<210> 4938
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4938
ccagucggua agut                                                         14


<210> 4939
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4939
ccagucggua agt                                                          13


<210> 4940
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4940
gccagucggu aaguucuguc                                                   20


<210> 4941
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4941
gccagucggu aaguucugt                                                    19


<210> 4942
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4942
gccagucggu aaguucug                                                     18


<210> 4943
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4943
gccagucggu aaguuct                                                      17


<210> 4944
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4944
gccagucggu aaguuc                                                       16


<210> 4945
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4945
gccagucggu aagut                                                        15


<210> 4946
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4946
gccagucggu aagt                                                         14


<210> 4947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4947
ucaaggaaga uggcauuuct                                                   20


<210> 4948
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 4948
ucaaggaaga uggcauuucu ag                                                22


<210> 4949
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4949
ucaaggaaga uggcat                                                       16


<210> 4950
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4950
gaagauggca uuuct                                                        15


<210> 4951
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 4951
ucaaggaaga uggcauuucu a                                                 21


<210> 4952
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4952
ucaaggaaga uggcauuuc                                                    19


<210> 4953
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4953
ucaaggaaga uggcauut                                                     18


<210> 4954
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4954
ucaaggaaga uggcaut                                                      17


<210> 4955
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4955
ucaaggaaga uggca                                                        15


<210> 4956
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4956
ucaaggaaga uggc                                                         14


<210> 4957
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4957
ucaaggaaga ugg                                                          13


<210> 4958
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4958
ucaaggaaga ug                                                           12


<210> 4959
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4959
ucaaggaaga t                                                            11


<210> 4960
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4960
ucaaggaaga                                                              10


<210> 4961
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4961
ucaaggaag                                                                9


<210> 4962
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 4962
caaggaagau ggcauuucua g                                                 21


<210> 4963
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4963
caaggaagau ggcauuucua                                                   20


<210> 4964
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4964
caaggaagau ggcauuuct                                                    19


<210> 4965
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4965
caaggaagau ggcauuuc                                                     18


<210> 4966
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4966
caaggaagau ggcauut                                                      17


<210> 4967
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4967
caaggaagau ggcaut                                                       16


<210> 4968
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4968
caaggaagau ggcat                                                        15


<210> 4969
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4969
caaggaagau ggca                                                         14


<210> 4970
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4970
caaggaagau ggc                                                          13


<210> 4971
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4971
caaggaagau gg                                                           12


<210> 4972
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4972
caaggaagau g                                                            11


<210> 4973
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4973
caaggaagat                                                              10


<210> 4974
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4974
caaggaaga                                                                9


<210> 4975
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4975
caaggaag                                                                 8


<210> 4976
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 4976
aaggaagaug gcauuucuag                                                   20


<210> 4977
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4977
aaggaagaug gcauuucua                                                    19


<210> 4978
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4978
aaggaagaug gcauuuct                                                     18


<210> 4979
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4979
aaggaagaug gcauuuc                                                      17


<210> 4980
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4980
aaggaagaug gcauut                                                       16


<210> 4981
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4981
aaggaagaug gcaut                                                        15


<210> 4982
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4982
aaggaagaug gcat                                                         14


<210> 4983
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4983
aaggaagaug gca                                                          13


<210> 4984
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4984
aaggaagaug gc                                                           12


<210> 4985
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 4985
aaggaagaug g                                                            11


<210> 4986
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4986
aaggaagaug                                                              10


<210> 4987
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4987
aaggaagat                                                                9


<210> 4988
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4988
aaggaaga                                                                 8


<210> 4989
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 4989
aggaagaugg cauuucuag                                                    19


<210> 4990
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 4990
aggaagaugg cauuucua                                                     18


<210> 4991
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 4991
aggaagaugg cauuuct                                                      17


<210> 4992
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 4992
aggaagaugg cauuuc                                                       16


<210> 4993
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 4993
aggaagaugg cauut                                                        15


<210> 4994
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 4994
aggaagaugg caut                                                         14


<210> 4995
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 4995
aggaagaugg cat                                                          13


<210> 4996
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 4996
aggaagaugg ca                                                           12


<210> 4997
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 4997
aggaagaugg                                                              10


<210> 4998
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 4998
aggaagaug                                                                9


<210> 4999
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 4999
aggaagat                                                                 8


<210> 5000
<211> 18
<212> RNA
<213> Artificial Sequence

<220>	
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5000
ggaagauggc auuucuag                                                     18


<210> 5001
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5001
ggaagauggc auuucua                                                      17


<210> 5002
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5002
ggaagauggc auuuct                                                       16


<210> 5003
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5003
ggaagauggc auuuc                                                        15


<210> 5004
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5004
ggaagauggc auut                                                         14


<210> 5005
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5005
ggaagauggc aut                                                          13


<210> 5006
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5006
ggaagauggc at                                                           12


<210> 5007
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5007
ggaagauggc a                                                            11


<210> 5008
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5008
ggaagauggc                                                              10


<210> 5009
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5009
ggaagaug                                                                 8


<210> 5010
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5010
gaagauggca uuucuag                                                      17


<210> 5011
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5011
gaagauggca uuucua                                                       16


<210> 5012
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5012
gaagauggca uuuc                                                         14


<210> 5013
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5013
gaagauggca uut                                                          13


<210> 5014
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5014
gaagauggca ut                                                           12


<210> 5015
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5015
gaagauggca t                                                            11


<210> 5016
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5016
gaagauggca                                                              10


<210> 5017
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5017
gaagauggc                                                                9


<210> 5018
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5018
gaagaugg                                                                 8


<210> 5019
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5019
aagauggcau uucuag                                                       16


<210> 5020
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5020
aagauggcau uucua                                                        15


<210> 5021
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5021
aagauggcau uuct                                                         14


<210> 5022
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5022
aagauggcau uuc                                                          13


<210> 5023
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5023
aagauggcau ut                                                           12


<210> 5024
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5024
aagauggcau t                                                            11


<210> 5025
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5025
aagauggcat                                                              10


<210> 5026
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5026
aagauggca                                                                9


<210> 5027
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5027
aagauggc                                                                 8


<210> 5028
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5028
agauggcauu ucuag                                                        15


<210> 5029
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5029
agauggcauu ucua                                                         14


<210> 5030
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5030
agauggcauu uct                                                          13


<210> 5031
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5031
agauggcauu uc                                                           12


<210> 5032
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5032
agauggcauu t                                                            11


<210> 5033
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5033
agauggcaut                                                              10


<210> 5034
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5034
agauggcat                                                                9


<210> 5035
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5035
agauggca                                                                 8


<210> 5036
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 5036
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 5037
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 5037
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 5038
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 5038
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 5039
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 5039
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 5040
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 5040
cuccaacauc aaggaagaug gcauut                                            26


<210> 5041
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5041
cuccaacauc aaggaagaug gcaut                                             25


<210> 5042
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5042
cuccaacauc aaggaagaug gcat                                              24


<210> 5043
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5043
cuccaacauc aaggaagaug gca                                               23


<210> 5044
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5044
cuccaacauc aaggaagaug gc                                                22


<210> 5045
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5045
cuccaacauc aaggaagaug g                                                 21


<210> 5046
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5046
cuccaacauc aaggaagaug                                                   20


<210> 5047
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5047
cuccaacauc aaggaagat                                                    19


<210> 5048
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5048
cuccaacauc aaggaaga                                                     18


<210> 5049
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5049
cuccaacauc aaggaag                                                      17


<210> 5050
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 5050
uccaacauca aggaagaugg cauuucuag                                         29


<210> 5051
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 5051
uccaacauca aggaagaugg cauuucua                                          28


<210> 5052
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 5052
uccaacauca aggaagaugg cauuuct                                           27


<210> 5053
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 5053
uccaacauca aggaagaugg cauuuc                                            26


<210> 5054
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5054
uccaacauca aggaagaugg cauut                                             25


<210> 5055
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5055
uccaacauca aggaagaugg caut                                              24


<210> 5056
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5056
uccaacauca aggaagaugg cat                                               23


<210> 5057
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5057
uccaacauca aggaagaugg ca                                                22


<210> 5058
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5058
uccaacauca aggaagaugg c                                                 21


<210> 5059
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5059
uccaacauca aggaagaugg                                                   20


<210> 5060
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5060
uccaacauca aggaagaug                                                    19


<210> 5061
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5061
uccaacauca aggaagat                                                     18


<210> 5062
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5062
uccaacauca aggaaga                                                      17


<210> 5063
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5063
uccaacauca aggaag                                                       16


<210> 5064
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 5064
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 5065
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 5065
ccaacaucaa ggaagauggc auuucua                                           27


<210> 5066
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 5066
ccaacaucaa ggaagauggc auuuct                                            26


<210> 5067
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5067
ccaacaucaa ggaagauggc auuuc                                             25


<210> 5068
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5068
ccaacaucaa ggaagauggc auut                                              24


<210> 5069
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5069
ccaacaucaa ggaagauggc aut                                               23


<210> 5070
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5070
ccaacaucaa ggaagauggc at                                                22


<210> 5071
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5071
ccaacaucaa ggaagauggc a                                                 21


<210> 5072
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5072
ccaacaucaa ggaagauggc                                                   20


<210> 5073
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5073
ccaacaucaa ggaagaugg                                                    19


<210> 5074
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5074
ccaacaucaa ggaagaug                                                     18


<210> 5075
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5075
ccaacaucaa ggaagat                                                      17


<210> 5076
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5076
ccaacaucaa ggaaga                                                       16


<210> 5077
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5077
ccaacaucaa ggaag                                                        15


<210> 5078
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 5078
caacaucaag gaagauggca uuucuag                                           27


<210> 5079
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 5079
caacaucaag gaagauggca uuucua                                            26


<210> 5080
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5080
caacaucaag gaagauggca uuuct                                             25


<210> 5081
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5081
caacaucaag gaagauggca uuuc                                              24


<210> 5082
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5082
caacaucaag gaagauggca uut                                               23


<210> 5083
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5083
caacaucaag gaagauggca ut                                                22


<210> 5084
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5084
caacaucaag gaagauggca t                                                 21


<210> 5085
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5085
caacaucaag gaagauggca                                                   20


<210> 5086
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5086
caacaucaag gaagauggc                                                    19


<210> 5087
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5087
caacaucaag gaagaugg                                                     18


<210> 5088
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5088
caacaucaag gaagaug                                                      17


<210> 5089
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5089
caacaucaag gaagat                                                       16


<210> 5090
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5090
caacaucaag gaaga                                                        15


<210> 5091
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5091
caacaucaag gaag                                                         14


<210> 5092
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 5092
aacaucaagg aagauggcau uucuag                                            26


<210> 5093
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5093
aacaucaagg aagauggcau uucua                                             25


<210> 5094
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5094
aacaucaagg aagauggcau uuct                                              24


<210> 5095
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5095
aacaucaagg aagauggcau uuc                                               23


<210> 5096
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5096
aacaucaagg aagauggcau ut                                                22


<210> 5097
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5097
aacaucaagg aagauggcau t                                                 21


<210> 5098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5098
aacaucaagg aagauggcat                                                   20


<210> 5099
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5099
aacaucaagg aagauggca                                                    19


<210> 5100
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5100
aacaucaagg aagauggc                                                     18


<210> 5101
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5101
aacaucaagg aagaugg                                                      17


<210> 5102
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5102
aacaucaagg aagaug                                                       16


<210> 5103
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5103
aacaucaagg aagat                                                        15


<210> 5104
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5104
aacaucaagg aaga                                                         14


<210> 5105
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5105
aacaucaagg aag                                                          13


<210> 5106
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5106
acaucaagga agauggcauu ucuag                                             25


<210> 5107
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5107
acaucaagga agauggcauu ucua                                              24


<210> 5108
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5108
acaucaagga agauggcauu uct                                               23


<210> 5109
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5109
acaucaagga agauggcauu uc                                                22


<210> 5110
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5110
acaucaagga agauggcauu t                                                 21


<210> 5111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5111
acaucaagga agauggcaut                                                   20


<210> 5112
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5112
acaucaagga agauggcat                                                    19


<210> 5113
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5113
acaucaagga agauggca                                                     18


<210> 5114
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5114
acaucaagga agauggc                                                      17


<210> 5115
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5115
acaucaagga agaugg                                                       16


<210> 5116
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5116
acaucaagga agaug                                                        15


<210> 5117
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5117
acaucaagga agat                                                         14


<210> 5118
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5118
acaucaagga aga                                                          13


<210> 5119
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5119
acaucaagga ag                                                           12


<210> 5120
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5120
caucaaggaa gauggcauuu cuag                                              24


<210> 5121
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5121
caucaaggaa gauggcauuu cua                                               23


<210> 5122
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5122
caucaaggaa gauggcauuu ct                                                22


<210> 5123
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5123
caucaaggaa gauggcauuu c                                                 21


<210> 5124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5124
caucaaggaa gauggcauut                                                   20


<210> 5125
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5125
caucaaggaa gauggcaut                                                    19


<210> 5126
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5126
caucaaggaa gauggcat                                                     18


<210> 5127
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5127
caucaaggaa gauggca                                                      17


<210> 5128
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5128
caucaaggaa gauggc                                                       16


<210> 5129
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5129
caucaaggaa gaugg                                                        15


<210> 5130
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5130
caucaaggaa gaug                                                         14


<210> 5131
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5131
caucaaggaa gat                                                          13


<210> 5132
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5132
caucaaggaa ga                                                           12


<210> 5133
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5133
caucaaggaa g                                                            11


<210> 5134
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5134
aucaaggaag auggcauuuc uag                                               23


<210> 5135
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5135
aucaaggaag auggcauuuc ua                                                22


<210> 5136
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5136
aucaaggaag auggcauuuc t                                                 21


<210> 5137
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5137
aucaaggaag auggcauuuc                                                   20


<210> 5138
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5138
aucaaggaag auggcauut                                                    19


<210> 5139
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5139
aucaaggaag auggcaut                                                     18


<210> 5140
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5140
aucaaggaag auggcat                                                      17


<210> 5141
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5141
aucaaggaag auggca                                                       16


<210> 5142
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5142
aucaaggaag auggc                                                        15


<210> 5143
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5143
aucaaggaag augg                                                         14


<210> 5144
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5144
aucaaggaag aug                                                          13


<210> 5145
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5145
aucaaggaag at                                                           12


<210> 5146
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5146
aucaaggaag a                                                            11


<210> 5147
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5147
aucaaggaag                                                              10


<210> 5148
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5148
ccagagcagg uaccuccaac auc                                               23


<210> 5149
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5149
ccagagcagg uaccucca                                                     18


<210> 5150
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5150
ccucugugau uuuauaacuu gat                                               23


<210> 5151
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5151
ucacccacca ucaccct                                                      17


<210> 5152
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5152
ugauauccuc aaggucaccc                                                   20


<210> 5153
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5153
cugcuugaug aucaucucgu ug                                                22


<210> 5154
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5154
cugcuugaug aucaucuc                                                     18


<210> 5155
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5155
guuuccuuag uaaccacag                                                    19


<210> 5156
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5156
guuuccuuag uaaccac                                                      17


<210> 5157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5157
ucaaggaaga uggcauuuct                                                   20


<210> 5158
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5158
ucaaggaaga uggcauuucu ag                                                22


<210> 5159
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5159
gguaaguucu guccaagc                                                     18


<210> 5160
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5160
guaaguucug uccaagcc                                                     18


<210> 5161
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5161
agucgguaag uucugucc                                                     18


<210> 5162
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5162
cuguccaagc ccgguuga                                                     18


<210> 5163
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5163
uaaguucugu ccaag                                                        15


<210> 5164
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5164
uucuguccaa gcccgguuga                                                   20


<210> 5165
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5165
uucuguccaa gcccgguug                                                    19


<210> 5166
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5166
uucuguccaa gcccggut                                                     18


<210> 5167
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5167
uucuguccaa gcccggt                                                      17


<210> 5168
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5168
uucuguccaa gcccgg                                                       16


<210> 5169
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5169
uucuguccaa gcccg                                                        15


<210> 5170
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5170
uucuguccaa gccc                                                         14


<210> 5171
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5171
uucuguccaa gcc                                                          13


<210> 5172
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5172
uucuguccaa gc                                                           12


<210> 5173
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5173
uucuguccaa g                                                            11


<210> 5174
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5174
uucuguccaa                                                              10


<210> 5175
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5175
uucugucca                                                                9


<210> 5176
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5176
uucugucc                                                                 8


<210> 5177
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5177
ucuguccaag cccgguuga                                                    19


<210> 5178
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5178
ucuguccaag cccgguug                                                     18


<210> 5179
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5179
ucuguccaag cccggut                                                      17


<210> 5180
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5180
ucuguccaag cccggt                                                       16


<210> 5181
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5181
ucuguccaag cccgg                                                        15


<210> 5182
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5182
ucuguccaag cccg                                                         14


<210> 5183
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5183
ucuguccaag ccc                                                          13


<210> 5184
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5184
ucuguccaag cc                                                           12


<210> 5185
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5185
ucuguccaag c                                                            11


<210> 5186
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5186
ucuguccaag                                                              10


<210> 5187
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5187
ucuguccaa                                                                9


<210> 5188
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5188
ucugucca                                                                 8


<210> 5189
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5189
cuguccaagc ccgguug                                                      17


<210> 5190
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5190
cuguccaagc ccggut                                                       16


<210> 5191
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5191
cuguccaagc ccggt                                                        15


<210> 5192
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5192
cuguccaagc ccgg                                                         14


<210> 5193
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5193
cuguccaagc ccg                                                          13


<210> 5194
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5194
cuguccaagc cc                                                           12


<210> 5195
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5195
cuguccaagc c                                                            11


<210> 5196
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5196
cuguccaagc                                                              10


<210> 5197
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5197
cuguccaag                                                                9


<210> 5198
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5198
cuguccaa                                                                 8


<210> 5199
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5199
guucugucca agcccgguug                                                   20


<210> 5200
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5200
guucugucca agcccggut                                                    19


<210> 5201
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5201
guucugucca agcccggt                                                     18


<210> 5202
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5202
guucugucca agcccgg                                                      17


<210> 5203
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5203
guucugucca agcccg                                                       16


<210> 5204
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5204
guucugucca agccc                                                        15


<210> 5205
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5205
guucugucca agcc                                                         14


<210> 5206
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5206
guucugucca agc                                                          13


<210> 5207
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5207
guucugucca ag                                                           12


<210> 5208
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5208
guucugucca a                                                            11


<210> 5209
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5209
guucugucca                                                              10


<210> 5210
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5210
guucugucc                                                                9


<210> 5211
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5211
guucuguc                                                                 8


<210> 5212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5212
aguucugucc aagcccggut                                                   20


<210> 5213
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5213
aguucugucc aagcccggt                                                    19


<210> 5214
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5214
aguucugucc aagcccgg                                                     18


<210> 5215
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5215
aguucugucc aagcccg                                                      17


<210> 5216
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5216
aguucugucc aagccc                                                       16


<210> 5217
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5217
aguucugucc aagcc                                                        15


<210> 5218
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5218
aguucugucc aagc                                                         14


<210> 5219
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5219
aguucugucc aag                                                          13


<210> 5220
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5220
aguucugucc aa                                                           12


<210> 5221
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5221
aguucugucc a                                                            11


<210> 5222
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5222
aguucugucc                                                              10


<210> 5223
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5223
aguucuguc                                                                9


<210> 5224
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5224
aguucugt                                                                 8


<210> 5225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5225
aaguucuguc caagcccggt                                                   20


<210> 5226
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5226
aaguucuguc caagcccgg                                                    19


<210> 5227
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5227
aaguucuguc caagcccg                                                     18


<210> 5228
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5228
aaguucuguc caagccc                                                      17


<210> 5229
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5229
aaguucuguc caagcc                                                       16


<210> 5230
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5230
aaguucuguc caagc                                                        15


<210> 5231
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5231
aaguucuguc caag                                                         14


<210> 5232
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5232
aaguucuguc caa                                                          13


<210> 5233
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5233
aaguucuguc ca                                                           12


<210> 5234
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5234
aaguucuguc c                                                            11


<210> 5235
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5235
aaguucuguc                                                              10


<210> 5236
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5236
aaguucugt                                                                9


<210> 5237
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5237
aaguucug                                                                 8


<210> 5238
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5238
uaaguucugu ccaagcccgg                                                   20


<210> 5239
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5239
uaaguucugu ccaagcccg                                                    19


<210> 5240
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5240
uaaguucugu ccaagccc                                                     18


<210> 5241
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5241
uaaguucugu ccaagcc                                                      17


<210> 5242
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5242
uaaguucugu ccaagc                                                       16


<210> 5243
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5243
uaaguucugu ccaa                                                         14


<210> 5244
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5244
uaaguucugu cca                                                          13


<210> 5245
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5245
uaaguucugu cc                                                           12


<210> 5246
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5246
uaaguucugu c                                                            11


<210> 5247
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5247
uaaguucugt                                                              10


<210> 5248
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5248
uaaguucug                                                                9


<210> 5249
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5249
uaaguuct                                                                 8


<210> 5250
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5250
guaaguucug uccaagcccg                                                   20


<210> 5251
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5251
guaaguucug uccaagccc                                                    19


<210> 5252
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5252
guaaguucug uccaagc                                                      17


<210> 5253
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5253
guaaguucug uccaag                                                       16


<210> 5254
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5254
guaaguucug uccaa                                                        15


<210> 5255
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5255
guaaguucug ucca                                                         14


<210> 5256
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5256
guaaguucug ucc                                                          13


<210> 5257
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5257
guaaguucug uc                                                           12


<210> 5258
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5258
guaaguucug t                                                            11


<210> 5259
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5259
guaaguucug                                                              10


<210> 5260
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5260
guaaguuct                                                                9


<210> 5261
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5261
guaaguuc                                                                 8


<210> 5262
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5262
gguaaguucu guccaagccc                                                   20


<210> 5263
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5263
gguaaguucu guccaagcc                                                    19


<210> 5264
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5264
gguaaguucu guccaag                                                      17


<210> 5265
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5265
gguaaguucu guccaa                                                       16


<210> 5266
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5266
gguaaguucu gucca                                                        15


<210> 5267
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5267
gguaaguucu gucc                                                         14


<210> 5268
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5268
gguaaguucu guc                                                          13


<210> 5269
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5269
gguaaguucu gt                                                           12


<210> 5270
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5270
gguaaguucu g                                                            11


<210> 5271
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5271
gguaaguuct                                                              10


<210> 5272
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5272
gguaaguuc                                                                9


<210> 5273
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5273
gguaagut                                                                 8


<210> 5274
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5274
cgguaaguuc uguccaagcc                                                   20


<210> 5275
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5275
cgguaaguuc uguccaagc                                                    19


<210> 5276
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5276
cgguaaguuc uguccaag                                                     18


<210> 5277
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5277
cgguaaguuc uguccaa                                                      17


<210> 5278
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5278
cgguaaguuc ugucca                                                       16


<210> 5279
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5279
cgguaaguuc ugucc                                                        15


<210> 5280
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5280
cgguaaguuc uguc                                                         14


<210> 5281
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5281
cgguaaguuc ugt                                                          13


<210> 5282
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5282
cgguaaguuc ug                                                           12


<210> 5283
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5283
cgguaaguuc t                                                            11


<210> 5284
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5284
cgguaaguuc                                                              10


<210> 5285
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5285
cgguaagut                                                                9


<210> 5286
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5286
cgguaagt                                                                 8


<210> 5287
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5287
ucgguaaguu cuguccaagc                                                   20


<210> 5288
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5288
ucgguaaguu cuguccaag                                                    19


<210> 5289
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5289
ucgguaaguu cuguccaa                                                     18


<210> 5290
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5290
ucgguaaguu cugucca                                                      17


<210> 5291
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5291
ucgguaaguu cugucc                                                       16


<210> 5292
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5292
ucgguaaguu cuguc                                                        15


<210> 5293
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5293
ucgguaaguu cugt                                                         14


<210> 5294
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5294
ucgguaaguu cug                                                          13


<210> 5295
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5295
ucgguaaguu ct                                                           12


<210> 5296
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5296
ucgguaaguu c                                                            11


<210> 5297
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5297
ucgguaagut                                                              10


<210> 5298
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5298
ucgguaagt                                                                9


<210> 5299
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5299
gucgguaagu ucuguccaag                                                   20


<210> 5300
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5300
gucgguaagu ucuguccaa                                                    19


<210> 5301
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5301
gucgguaagu ucugucca                                                     18


<210> 5302
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5302
gucgguaagu ucugucc                                                      17


<210> 5303
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5303
gucgguaagu ucuguc                                                       16


<210> 5304
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5304
gucgguaagu ucugt                                                        15


<210> 5305
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5305
gucgguaagu ucug                                                         14


<210> 5306
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5306
gucgguaagu uct                                                          13


<210> 5307
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5307
gucgguaagu uc                                                           12


<210> 5308
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5308
gucgguaagu t                                                            11


<210> 5309
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5309
gucgguaagt                                                              10


<210> 5310
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5310
agucgguaag uucuguccaa                                                   20


<210> 5311
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5311
agucgguaag uucugucca                                                    19


<210> 5312
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5312
agucgguaag uucuguc                                                      17


<210> 5313
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5313
agucgguaag uucugt                                                       16


<210> 5314
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5314
agucgguaag uucug                                                        15


<210> 5315
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5315
agucgguaag uuct                                                         14


<210> 5316
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5316
agucgguaag uuc                                                          13


<210> 5317
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5317
agucgguaag ut                                                           12


<210> 5318
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5318
agucgguaag t                                                            11


<210> 5319
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5319
cagucgguaa guucugucca                                                   20


<210> 5320
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5320
cagucgguaa guucugucc                                                    19


<210> 5321
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5321
cagucgguaa guucuguc                                                     18


<210> 5322
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5322
cagucgguaa guucugt                                                      17


<210> 5323
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5323
cagucgguaa guucug                                                       16


<210> 5324
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5324
cagucgguaa guuct                                                        15


<210> 5325
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5325
cagucgguaa guuc                                                         14


<210> 5326
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5326
cagucgguaa gut                                                          13


<210> 5327
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5327
cagucgguaa gt                                                           12


<210> 5328
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5328
ccagucggua aguucugucc                                                   20


<210> 5329
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5329
ccagucggua aguucuguc                                                    19


<210> 5330
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5330
ccagucggua aguucugt                                                     18


<210> 5331
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5331
ccagucggua aguucug                                                      17


<210> 5332
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5332
ccagucggua aguuct                                                       16


<210> 5333
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5333
ccagucggua aguuc                                                        15


<210> 5334
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5334
ccagucggua agut                                                         14


<210> 5335
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5335
ccagucggua agt                                                          13


<210> 5336
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5336
gccagucggu aaguucuguc                                                   20


<210> 5337
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5337
gccagucggu aaguucugt                                                    19


<210> 5338
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5338
gccagucggu aaguucug                                                     18


<210> 5339
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5339
gccagucggu aaguuct                                                      17


<210> 5340
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5340
gccagucggu aaguuc                                                       16


<210> 5341
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5341
gccagucggu aagut                                                        15


<210> 5342
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5342
gccagucggu aagt                                                         14


<210> 5343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5343
ucaaggaaga uggcauuuct                                                   20


<210> 5344
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5344
ucaaggaaga uggcauuucu ag                                                22


<210> 5345
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5345
ucaaggaaga uggcat                                                       16


<210> 5346
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5346
gaagauggca uuuct                                                        15


<210> 5347
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5347
ucaaggaaga uggcauuucu a                                                 21


<210> 5348
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5348
ucaaggaaga uggcauuuc                                                    19


<210> 5349
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5349
ucaaggaaga uggcauut                                                     18


<210> 5350
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5350
ucaaggaaga uggcaut                                                      17


<210> 5351
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5351
ucaaggaaga uggca                                                        15


<210> 5352
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5352
ucaaggaaga uggc                                                         14


<210> 5353
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5353
ucaaggaaga ugg                                                          13


<210> 5354
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5354
ucaaggaaga ug                                                           12


<210> 5355
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5355
ucaaggaaga t                                                            11


<210> 5356
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5356
ucaaggaaga                                                              10


<210> 5357
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5357
ucaaggaag                                                                9


<210> 5358
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5358
caaggaagau ggcauuucua g                                                 21


<210> 5359
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5359
caaggaagau ggcauuucua                                                   20


<210> 5360
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5360
caaggaagau ggcauuuct                                                    19


<210> 5361
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5361
caaggaagau ggcauuuc                                                     18


<210> 5362
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5362
caaggaagau ggcauut                                                      17


<210> 5363
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5363
caaggaagau ggcaut                                                       16


<210> 5364
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5364
caaggaagau ggcat                                                        15


<210> 5365
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5365
caaggaagau ggca                                                         14


<210> 5366
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5366
caaggaagau ggc                                                          13


<210> 5367
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5367
caaggaagau gg                                                           12


<210> 5368
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5368
caaggaagau g                                                            11


<210> 5369
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5369
caaggaagat                                                              10


<210> 5370
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5370
caaggaaga                                                                9


<210> 5371
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5371
caaggaag                                                                 8


<210> 5372
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5372
aaggaagaug gcauuucuag                                                   20


<210> 5373
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5373
aaggaagaug gcauuucua                                                    19


<210> 5374
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5374
aaggaagaug gcauuuct                                                     18


<210> 5375
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5375
aaggaagaug gcauuuc                                                      17


<210> 5376
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5376
aaggaagaug gcauut                                                       16


<210> 5377
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5377
aaggaagaug gcaut                                                        15


<210> 5378
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5378
aaggaagaug gcat                                                         14


<210> 5379
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5379
aaggaagaug gca                                                          13


<210> 5380
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5380
aaggaagaug gc                                                           12


<210> 5381
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5381
aaggaagaug g                                                            11


<210> 5382
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5382
aaggaagaug                                                              10


<210> 5383
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5383
aaggaagat                                                                9


<210> 5384
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5384
aaggaaga                                                                 8


<210> 5385
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5385
aggaagaugg cauuucuag                                                    19


<210> 5386
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5386
aggaagaugg cauuucua                                                     18


<210> 5387
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5387
aggaagaugg cauuuct                                                      17


<210> 5388
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5388
aggaagaugg cauuuc                                                       16


<210> 5389
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5389
aggaagaugg cauut                                                        15


<210> 5390
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5390
aggaagaugg caut                                                         14


<210> 5391
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5391
aggaagaugg cat                                                          13


<210> 5392
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5392
aggaagaugg ca                                                           12


<210> 5393
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5393
aggaagaugg                                                              10


<210> 5394
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5394
aggaagaug                                                                9


<210> 5395
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5395
aggaagat                                                                 8


<210> 5396
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5396
ggaagauggc auuucuag                                                     18


<210> 5397
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5397
ggaagauggc auuucua                                                      17


<210> 5398
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5398
ggaagauggc auuuct                                                       16


<210> 5399
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5399
ggaagauggc auuuc                                                        15


<210> 5400
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5400
ggaagauggc auut                                                         14


<210> 5401
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5401
ggaagauggc aut                                                          13


<210> 5402
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5402
ggaagauggc at                                                           12


<210> 5403
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5403
ggaagauggc a                                                            11


<210> 5404
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5404
ggaagauggc                                                              10


<210> 5405
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5405
ggaagaug                                                                 8


<210> 5406
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5406
gaagauggca uuucuag                                                      17


<210> 5407
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5407
gaagauggca uuucua                                                       16


<210> 5408
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5408
gaagauggca uuuc                                                         14


<210> 5409
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5409
gaagauggca uut                                                          13


<210> 5410
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5410
gaagauggca ut                                                           12


<210> 5411
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5411
gaagauggca t                                                            11


<210> 5412
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5412
gaagauggca                                                              10


<210> 5413
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5413
gaagauggc                                                                9


<210> 5414
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5414
gaagaugg                                                                 8


<210> 5415
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5415
aagauggcau uucuag                                                       16


<210> 5416
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5416
aagauggcau uucua                                                        15


<210> 5417
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5417
aagauggcau uuct                                                         14


<210> 5418
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5418
aagauggcau uuc                                                          13


<210> 5419
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5419
aagauggcau ut                                                           12


<210> 5420
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5420
aagauggcau t                                                            11


<210> 5421
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5421
aagauggcat                                                              10


<210> 5422
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5422
aagauggca                                                                9


<210> 5423
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5423
aagauggc                                                                 8


<210> 5424
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5424
agauggcauu ucuag                                                        15


<210> 5425
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5425
agauggcauu ucua                                                         14


<210> 5426
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5426
agauggcauu uct                                                          13


<210> 5427
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5427
agauggcauu uc                                                           12


<210> 5428
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5428
agauggcauu t                                                            11


<210> 5429
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5429
agauggcaut                                                              10


<210> 5430
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 5430
agauggcat                                                                9


<210> 5431
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 5431
agauggca                                                                 8


<210> 5432
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 5432
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 5433
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 5433
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 5434
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 5434
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 5435
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 5435
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 5436
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 5436
cuccaacauc aaggaagaug gcauut                                            26


<210> 5437
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5437
cuccaacauc aaggaagaug gcaut                                             25


<210> 5438
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5438
cuccaacauc aaggaagaug gcat                                              24


<210> 5439
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5439
cuccaacauc aaggaagaug gca                                               23


<210> 5440
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5440
cuccaacauc aaggaagaug gc                                                22


<210> 5441
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5441
cuccaacauc aaggaagaug g                                                 21


<210> 5442
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5442
cuccaacauc aaggaagaug                                                   20


<210> 5443
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5443
cuccaacauc aaggaagat                                                    19


<210> 5444
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5444
cuccaacauc aaggaaga                                                     18


<210> 5445
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5445
cuccaacauc aaggaag                                                      17


<210> 5446
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 5446
uccaacauca aggaagaugg cauuucuag                                         29


<210> 5447
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 5447
uccaacauca aggaagaugg cauuucua                                          28


<210> 5448
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 5448
uccaacauca aggaagaugg cauuuct                                           27


<210> 5449
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 5449
uccaacauca aggaagaugg cauuuc                                            26


<210> 5450
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5450
uccaacauca aggaagaugg cauut                                             25


<210> 5451
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5451
uccaacauca aggaagaugg caut                                              24


<210> 5452
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5452
uccaacauca aggaagaugg cat                                               23


<210> 5453
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5453
uccaacauca aggaagaugg ca                                                22


<210> 5454
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5454
uccaacauca aggaagaugg c                                                 21


<210> 5455
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5455
uccaacauca aggaagaugg                                                   20


<210> 5456
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5456
uccaacauca aggaagaug                                                    19


<210> 5457
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5457
uccaacauca aggaagat                                                     18


<210> 5458
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5458
uccaacauca aggaaga                                                      17


<210> 5459
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5459
uccaacauca aggaag                                                       16


<210> 5460
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 5460
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 5461
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 5461
ccaacaucaa ggaagauggc auuucua                                           27


<210> 5462
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 5462
ccaacaucaa ggaagauggc auuuct                                            26


<210> 5463
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5463
ccaacaucaa ggaagauggc auuuc                                             25


<210> 5464
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5464
ccaacaucaa ggaagauggc auut                                              24


<210> 5465
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5465
ccaacaucaa ggaagauggc aut                                               23


<210> 5466
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5466
ccaacaucaa ggaagauggc at                                                22


<210> 5467
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5467
ccaacaucaa ggaagauggc a                                                 21


<210> 5468
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5468
ccaacaucaa ggaagauggc                                                   20


<210> 5469
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5469
ccaacaucaa ggaagaugg                                                    19


<210> 5470
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5470
ccaacaucaa ggaagaug                                                     18


<210> 5471
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5471
ccaacaucaa ggaagat                                                      17


<210> 5472
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5472
ccaacaucaa ggaaga                                                       16


<210> 5473
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5473
ccaacaucaa ggaag                                                        15


<210> 5474
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 5474
caacaucaag gaagauggca uuucuag                                           27


<210> 5475
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 5475
caacaucaag gaagauggca uuucua                                            26


<210> 5476
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5476
caacaucaag gaagauggca uuuct                                             25


<210> 5477
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5477
caacaucaag gaagauggca uuuc                                              24


<210> 5478
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5478
caacaucaag gaagauggca uut                                               23


<210> 5479
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5479
caacaucaag gaagauggca ut                                                22


<210> 5480
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5480
caacaucaag gaagauggca t                                                 21


<210> 5481
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5481
caacaucaag gaagauggca                                                   20


<210> 5482
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5482
caacaucaag gaagauggc                                                    19


<210> 5483
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5483
caacaucaag gaagaugg                                                     18


<210> 5484
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5484
caacaucaag gaagaug                                                      17


<210> 5485
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5485
caacaucaag gaagat                                                       16


<210> 5486
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5486
caacaucaag gaaga                                                        15


<210> 5487
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5487
caacaucaag gaag                                                         14


<210> 5488
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 5488
aacaucaagg aagauggcau uucuag                                            26


<210> 5489
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5489
aacaucaagg aagauggcau uucua                                             25


<210> 5490
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5490
aacaucaagg aagauggcau uuct                                              24


<210> 5491
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5491
aacaucaagg aagauggcau uuc                                               23


<210> 5492
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5492
aacaucaagg aagauggcau ut                                                22


<210> 5493
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5493
aacaucaagg aagauggcau t                                                 21


<210> 5494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5494
aacaucaagg aagauggcat                                                   20


<210> 5495
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5495
aacaucaagg aagauggca                                                    19


<210> 5496
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5496
aacaucaagg aagauggc                                                     18


<210> 5497
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5497
aacaucaagg aagaugg                                                      17


<210> 5498
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5498
aacaucaagg aagaug                                                       16


<210> 5499
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5499
aacaucaagg aagat                                                        15


<210> 5500
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5500
aacaucaagg aaga                                                         14


<210> 5501
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5501
aacaucaagg aag                                                          13


<210> 5502
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 5502
acaucaagga agauggcauu ucuag                                             25


<210> 5503
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5503
acaucaagga agauggcauu ucua                                              24


<210> 5504
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5504
acaucaagga agauggcauu uct                                               23


<210> 5505
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5505
acaucaagga agauggcauu uc                                                22


<210> 5506
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5506
acaucaagga agauggcauu t                                                 21


<210> 5507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5507
acaucaagga agauggcaut                                                   20


<210> 5508
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5508
acaucaagga agauggcat                                                    19


<210> 5509
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5509
acaucaagga agauggca                                                     18


<210> 5510
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5510
acaucaagga agauggc                                                      17


<210> 5511
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5511
acaucaagga agaugg                                                       16


<210> 5512
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5512
acaucaagga agaug                                                        15


<210> 5513
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5513
acaucaagga agat                                                         14


<210> 5514
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5514
acaucaagga aga                                                          13


<210> 5515
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5515
acaucaagga ag                                                           12


<210> 5516
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 5516
caucaaggaa gauggcauuu cuag                                              24


<210> 5517
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5517
caucaaggaa gauggcauuu cua                                               23


<210> 5518
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5518
caucaaggaa gauggcauuu ct                                                22


<210> 5519
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5519
caucaaggaa gauggcauuu c                                                 21


<210> 5520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5520
caucaaggaa gauggcauut                                                   20


<210> 5521
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5521
caucaaggaa gauggcaut                                                    19


<210> 5522
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5522
caucaaggaa gauggcat                                                     18


<210> 5523
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5523
caucaaggaa gauggca                                                      17


<210> 5524
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5524
caucaaggaa gauggc                                                       16


<210> 5525
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5525
caucaaggaa gaugg                                                        15


<210> 5526
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5526
caucaaggaa gaug                                                         14


<210> 5527
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5527
caucaaggaa gat                                                          13


<210> 5528
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5528
caucaaggaa ga                                                           12


<210> 5529
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5529
caucaaggaa g                                                            11


<210> 5530
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5530
aucaaggaag auggcauuuc uag                                               23


<210> 5531
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5531
aucaaggaag auggcauuuc ua                                                22


<210> 5532
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 5532
aucaaggaag auggcauuuc t                                                 21


<210> 5533
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5533
aucaaggaag auggcauuuc                                                   20


<210> 5534
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5534
aucaaggaag auggcauut                                                    19


<210> 5535
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5535
aucaaggaag auggcaut                                                     18


<210> 5536
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5536
aucaaggaag auggcat                                                      17


<210> 5537
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 5537
aucaaggaag auggca                                                       16


<210> 5538
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 5538
aucaaggaag auggc                                                        15


<210> 5539
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 5539
aucaaggaag augg                                                         14


<210> 5540
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 5540
aucaaggaag aug                                                          13


<210> 5541
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 5541
aucaaggaag at                                                           12


<210> 5542
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 5542
aucaaggaag a                                                            11


<210> 5543
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 5543
aucaaggaag                                                              10


<210> 5544
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5544
ccagagcagg uaccuccaac auc                                               23


<210> 5545
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5545
ccagagcagg uaccucca                                                     18


<210> 5546
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 5546
ccucugugau uuuauaacuu gat                                               23


<210> 5547
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5547
ucacccacca ucaccct                                                      17


<210> 5548
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 5548
ugauauccuc aaggucaccc                                                   20


<210> 5549
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 5549
cugcuugaug aucaucucgu ug                                                22


<210> 5550
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 5550
cugcuugaug aucaucuc                                                     18


<210> 5551
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 5551
guuuccuuag uaaccacag                                                    19


<210> 5552
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 5552
guuuccuuag uaaccac                                                      17


<210> 5553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5553
ucaaggaaga uggcauuuct                                                   20


<210> 5554
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5554
ucaaggaaga uggcauuucu ag                                                22


<210> 5555
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5555
gguaaguucu guccaagc                                                     18


<210> 5556
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5556
guaaguucug uccaagcc                                                     18


<210> 5557
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5557
agucgguaag uucugucc                                                     18


<210> 5558
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5558
cuguccaagc ccgguuga                                                     18


<210> 5559
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5559
uaaguucugu ccaag                                                        15


<210> 5560
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5560
uucuguccaa gcccgguuga                                                   20


<210> 5561
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5561
uucuguccaa gcccgguug                                                    19


<210> 5562
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5562
uucuguccaa gcccggut                                                     18


<210> 5563
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5563
uucuguccaa gcccggt                                                      17


<210> 5564
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5564
uucuguccaa gcccgg                                                       16


<210> 5565
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5565
uucuguccaa gcccg                                                        15


<210> 5566
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5566
uucuguccaa gccc                                                         14


<210> 5567
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5567
uucuguccaa gcc                                                          13


<210> 5568
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5568
uucuguccaa gc                                                           12


<210> 5569
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5569
uucuguccaa g                                                            11


<210> 5570
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5570
uucuguccaa                                                              10


<210> 5571
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5571
uucugucca                                                                9


<210> 5572
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5572
uucugucc                                                                 8


<210> 5573
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5573
ucuguccaag cccgguuga                                                    19


<210> 5574
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5574
ucuguccaag cccgguug                                                     18


<210> 5575
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5575
ucuguccaag cccggut                                                      17


<210> 5576
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5576
ucuguccaag cccggt                                                       16


<210> 5577
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5577
ucuguccaag cccgg                                                        15


<210> 5578
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5578
ucuguccaag cccg                                                         14


<210> 5579
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5579
ucuguccaag ccc                                                          13


<210> 5580
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5580
ucuguccaag cc                                                           12


<210> 5581
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5581
ucuguccaag c                                                            11


<210> 5582
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5582
ucuguccaag                                                              10


<210> 5583
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5583
ucuguccaa                                                                9


<210> 5584
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5584
ucugucca                                                                 8


<210> 5585
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5585
cuguccaagc ccgguug                                                      17


<210> 5586
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5586
cuguccaagc ccggut                                                       16


<210> 5587
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5587
cuguccaagc ccggt                                                        15


<210> 5588
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5588
cuguccaagc ccgg                                                         14


<210> 5589
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5589
cuguccaagc ccg                                                          13


<210> 5590
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5590
cuguccaagc cc                                                           12


<210> 5591
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5591
cuguccaagc c                                                            11


<210> 5592
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5592
cuguccaagc                                                              10


<210> 5593
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5593
cuguccaag                                                                9


<210> 5594
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5594
cuguccaa                                                                 8


<210> 5595
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5595
guucugucca agcccgguug                                                   20


<210> 5596
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5596
guucugucca agcccggut                                                    19


<210> 5597
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5597
guucugucca agcccggt                                                     18


<210> 5598
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5598
guucugucca agcccgg                                                      17


<210> 5599
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5599
guucugucca agcccg                                                       16


<210> 5600
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5600
guucugucca agccc                                                        15


<210> 5601
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5601
guucugucca agcc                                                         14


<210> 5602
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5602
guucugucca agc                                                          13


<210> 5603
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5603
guucugucca ag                                                           12


<210> 5604
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5604
guucugucca a                                                            11


<210> 5605
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5605
guucugucca                                                              10


<210> 5606
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5606
guucugucc                                                                9


<210> 5607
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5607
guucuguc                                                                 8


<210> 5608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5608
aguucugucc aagcccggut                                                   20


<210> 5609
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5609
aguucugucc aagcccggt                                                    19


<210> 5610
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5610
aguucugucc aagcccgg                                                     18


<210> 5611
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5611
aguucugucc aagcccg                                                      17


<210> 5612
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5612
aguucugucc aagccc                                                       16


<210> 5613
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5613
aguucugucc aagcc                                                        15


<210> 5614
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5614
aguucugucc aagc                                                         14


<210> 5615
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5615
aguucugucc aag                                                          13


<210> 5616
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5616
aguucugucc aa                                                           12


<210> 5617
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5617
aguucugucc a                                                            11


<210> 5618
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5618
aguucugucc                                                              10


<210> 5619
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5619
aguucuguc                                                                9


<210> 5620
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5620
aguucugt                                                                 8


<210> 5621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5621
aaguucuguc caagcccggt                                                   20


<210> 5622
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5622
aaguucuguc caagcccgg                                                    19


<210> 5623
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5623
aaguucuguc caagcccg                                                     18


<210> 5624
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5624
aaguucuguc caagccc                                                      17


<210> 5625
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5625
aaguucuguc caagcc                                                       16


<210> 5626
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5626
aaguucuguc caagc                                                        15


<210> 5627
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5627
aaguucuguc caag                                                         14


<210> 5628
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5628
aaguucuguc caa                                                          13


<210> 5629
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5629
aaguucuguc ca                                                           12


<210> 5630
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5630
aaguucuguc c                                                            11


<210> 5631
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5631
aaguucuguc                                                              10


<210> 5632
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5632
aaguucugt                                                                9


<210> 5633
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5633
aaguucug                                                                 8


<210> 5634
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5634
uaaguucugu ccaagcccgg                                                   20


<210> 5635
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5635
uaaguucugu ccaagcccg                                                    19


<210> 5636
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5636
uaaguucugu ccaagccc                                                     18


<210> 5637
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5637
uaaguucugu ccaagcc                                                      17


<210> 5638
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5638
uaaguucugu ccaagc                                                       16


<210> 5639
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5639
uaaguucugu ccaa                                                         14


<210> 5640
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5640
uaaguucugu cca                                                          13


<210> 5641
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5641
uaaguucugu cc                                                           12


<210> 5642
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5642
uaaguucugu c                                                            11


<210> 5643
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5643
uaaguucugt                                                              10


<210> 5644
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5644
uaaguucug                                                                9


<210> 5645
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5645
uaaguuct                                                                 8


<210> 5646
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5646
guaaguucug uccaagcccg                                                   20


<210> 5647
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5647
guaaguucug uccaagccc                                                    19


<210> 5648
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5648
guaaguucug uccaagc                                                      17


<210> 5649
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5649
guaaguucug uccaag                                                       16


<210> 5650
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5650
guaaguucug uccaa                                                        15


<210> 5651
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5651
guaaguucug ucca                                                         14


<210> 5652
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5652
guaaguucug ucc                                                          13


<210> 5653
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5653
guaaguucug uc                                                           12


<210> 5654
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5654
guaaguucug t                                                            11


<210> 5655
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5655
guaaguucug                                                              10


<210> 5656
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5656
guaaguuct                                                                9


<210> 5657
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5657
guaaguuc                                                                 8


<210> 5658
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5658
gguaaguucu guccaagccc                                                   20


<210> 5659
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5659
gguaaguucu guccaagcc                                                    19


<210> 5660
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5660
gguaaguucu guccaag                                                      17


<210> 5661
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5661
gguaaguucu guccaa                                                       16


<210> 5662
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5662
gguaaguucu gucca                                                        15


<210> 5663
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5663
gguaaguucu gucc                                                         14


<210> 5664
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5664
gguaaguucu guc                                                          13


<210> 5665
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5665
gguaaguucu gt                                                           12


<210> 5666
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5666
gguaaguucu g                                                            11


<210> 5667
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5667
gguaaguuct                                                              10


<210> 5668
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5668
gguaaguuc                                                                9


<210> 5669
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5669
gguaagut                                                                 8


<210> 5670
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5670
cgguaaguuc uguccaagcc                                                   20


<210> 5671
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5671
cgguaaguuc uguccaagc                                                    19


<210> 5672
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5672
cgguaaguuc uguccaag                                                     18


<210> 5673
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5673
cgguaaguuc uguccaa                                                      17


<210> 5674
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5674
cgguaaguuc ugucca                                                       16


<210> 5675
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5675
cgguaaguuc ugucc                                                        15


<210> 5676
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5676
cgguaaguuc uguc                                                         14


<210> 5677
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5677
cgguaaguuc ugt                                                          13


<210> 5678
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5678
cgguaaguuc ug                                                           12


<210> 5679
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5679
cgguaaguuc t                                                            11


<210> 5680
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5680
cgguaaguuc                                                              10


<210> 5681
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5681
cgguaagut                                                                9


<210> 5682
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5682
cgguaagt                                                                 8


<210> 5683
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5683
ucgguaaguu cuguccaagc                                                   20


<210> 5684
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5684
ucgguaaguu cuguccaag                                                    19


<210> 5685
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5685
ucgguaaguu cuguccaa                                                     18


<210> 5686
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5686
ucgguaaguu cugucca                                                      17


<210> 5687
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5687
ucgguaaguu cugucc                                                       16


<210> 5688
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5688
ucgguaaguu cuguc                                                        15


<210> 5689
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5689
ucgguaaguu cugt                                                         14


<210> 5690
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5690
ucgguaaguu cug                                                          13


<210> 5691
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5691
ucgguaaguu ct                                                           12


<210> 5692
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5692
ucgguaaguu c                                                            11


<210> 5693
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5693
ucgguaagut                                                              10


<210> 5694
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5694
ucgguaagt                                                                9


<210> 5695
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5695
gucgguaagu ucuguccaag                                                   20


<210> 5696
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5696
gucgguaagu ucuguccaa                                                    19


<210> 5697
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5697
gucgguaagu ucugucca                                                     18


<210> 5698
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5698
gucgguaagu ucugucc                                                      17


<210> 5699
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5699
gucgguaagu ucuguc                                                       16


<210> 5700
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5700
gucgguaagu ucugt                                                        15


<210> 5701
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5701
gucgguaagu ucug                                                         14


<210> 5702
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5702
gucgguaagu uct                                                          13


<210> 5703
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5703
gucgguaagu uc                                                           12


<210> 5704
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5704
gucgguaagu t                                                            11


<210> 5705
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5705
gucgguaagt                                                              10


<210> 5706
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5706
agucgguaag uucuguccaa                                                   20


<210> 5707
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5707
agucgguaag uucugucca                                                    19


<210> 5708
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5708
agucgguaag uucuguc                                                      17


<210> 5709
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5709
agucgguaag uucugt                                                       16


<210> 5710
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5710
agucgguaag uucug                                                        15


<210> 5711
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5711
agucgguaag uuct                                                         14


<210> 5712
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5712
agucgguaag uuc                                                          13


<210> 5713
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5713
agucgguaag ut                                                           12


<210> 5714
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5714
agucgguaag t                                                            11


<210> 5715
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5715
cagucgguaa guucugucca                                                   20


<210> 5716
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5716
cagucgguaa guucugucc                                                    19


<210> 5717
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5717
cagucgguaa guucuguc                                                     18


<210> 5718
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5718
cagucgguaa guucugt                                                      17


<210> 5719
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5719
cagucgguaa guucug                                                       16


<210> 5720
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5720
cagucgguaa guuct                                                        15


<210> 5721
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5721
cagucgguaa guuc                                                         14


<210> 5722
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5722
cagucgguaa gut                                                          13


<210> 5723
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5723
cagucgguaa gt                                                           12


<210> 5724
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5724
ccagucggua aguucugucc                                                   20


<210> 5725
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5725
ccagucggua aguucuguc                                                    19


<210> 5726
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5726
ccagucggua aguucugt                                                     18


<210> 5727
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5727
ccagucggua aguucug                                                      17


<210> 5728
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5728
ccagucggua aguuct                                                       16


<210> 5729
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5729
ccagucggua aguuc                                                        15


<210> 5730
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5730
ccagucggua agut                                                         14


<210> 5731
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5731
ccagucggua agt                                                          13


<210> 5732
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5732
gccagucggu aaguucuguc                                                   20


<210> 5733
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5733
gccagucggu aaguucugt                                                    19


<210> 5734
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5734
gccagucggu aaguucug                                                     18


<210> 5735
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5735
gccagucggu aaguuct                                                      17


<210> 5736
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5736
gccagucggu aaguuc                                                       16


<210> 5737
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5737
gccagucggu aagut                                                        15


<210> 5738
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5738
gccagucggu aagt                                                         14


<210> 5739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5739
ucaaggaaga uggcauuuct                                                   20


<210> 5740
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5740
ucaaggaaga uggcauuucu ag                                                22


<210> 5741
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5741
ucaaggaaga uggcat                                                       16


<210> 5742
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5742
gaagauggca uuuct                                                        15


<210> 5743
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5743
ucaaggaaga uggcauuucu a                                                 21


<210> 5744
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5744
ucaaggaaga uggcauuuc                                                    19


<210> 5745
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5745
ucaaggaaga uggcauut                                                     18


<210> 5746
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5746
ucaaggaaga uggcaut                                                      17


<210> 5747
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5747
ucaaggaaga uggca                                                        15


<210> 5748
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5748
ucaaggaaga uggc                                                         14


<210> 5749
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5749
ucaaggaaga ugg                                                          13


<210> 5750
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5750
ucaaggaaga ug                                                           12


<210> 5751
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5751
ucaaggaaga t                                                            11


<210> 5752
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5752
ucaaggaaga                                                              10


<210> 5753
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5753
ucaaggaag                                                                9


<210> 5754
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5754
caaggaagau ggcauuucua g                                                 21


<210> 5755
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5755
caaggaagau ggcauuucua                                                   20


<210> 5756
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5756
caaggaagau ggcauuuct                                                    19


<210> 5757
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5757
caaggaagau ggcauuuc                                                     18


<210> 5758
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5758
caaggaagau ggcauut                                                      17


<210> 5759
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5759
caaggaagau ggcaut                                                       16


<210> 5760
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5760
caaggaagau ggcat                                                        15


<210> 5761
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5761
caaggaagau ggca                                                         14


<210> 5762
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5762
caaggaagau ggc                                                          13


<210> 5763
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5763
caaggaagau gg                                                           12


<210> 5764
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5764
caaggaagau g                                                            11


<210> 5765
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5765
caaggaagat                                                              10


<210> 5766
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5766
caaggaaga                                                                9


<210> 5767
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5767
caaggaag                                                                 8


<210> 5768
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5768
aaggaagaug gcauuucuag                                                   20


<210> 5769
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5769
aaggaagaug gcauuucua                                                    19


<210> 5770
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5770
aaggaagaug gcauuuct                                                     18


<210> 5771
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5771
aaggaagaug gcauuuc                                                      17


<210> 5772
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5772
aaggaagaug gcauut                                                       16


<210> 5773
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5773
aaggaagaug gcaut                                                        15


<210> 5774
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5774
aaggaagaug gcat                                                         14


<210> 5775
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5775
aaggaagaug gca                                                          13


<210> 5776
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5776
aaggaagaug gc                                                           12


<210> 5777
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5777
aaggaagaug g                                                            11


<210> 5778
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5778
aaggaagaug                                                              10


<210> 5779
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5779
aaggaagat                                                                9


<210> 5780
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5780
aaggaaga                                                                 8


<210> 5781
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5781
aggaagaugg cauuucuag                                                    19


<210> 5782
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5782
aggaagaugg cauuucua                                                     18


<210> 5783
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5783
aggaagaugg cauuuct                                                      17


<210> 5784
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5784
aggaagaugg cauuuc                                                       16


<210> 5785
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5785
aggaagaugg cauut                                                        15


<210> 5786
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5786
aggaagaugg caut                                                         14


<210> 5787
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5787
aggaagaugg cat                                                          13


<210> 5788
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5788
aggaagaugg ca                                                           12


<210> 5789
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5789
aggaagaugg                                                              10


<210> 5790
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5790
aggaagaug                                                                9


<210> 5791
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5791
aggaagat                                                                 8


<210> 5792
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5792
ggaagauggc auuucuag                                                     18


<210> 5793
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5793
ggaagauggc auuucua                                                      17


<210> 5794
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5794
ggaagauggc auuuct                                                       16


<210> 5795
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5795
ggaagauggc auuuc                                                        15


<210> 5796
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5796
ggaagauggc auut                                                         14


<210> 5797
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5797
ggaagauggc aut                                                          13


<210> 5798
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5798
ggaagauggc at                                                           12


<210> 5799
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5799
ggaagauggc a                                                            11


<210> 5800
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5800
ggaagauggc                                                              10


<210> 5801
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5801
ggaagaug                                                                 8


<210> 5802
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5802
gaagauggca uuucuag                                                      17


<210> 5803
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5803
gaagauggca uuucua                                                       16


<210> 5804
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5804
gaagauggca uuuc                                                         14


<210> 5805
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5805
gaagauggca uut                                                          13


<210> 5806
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5806
gaagauggca ut                                                           12


<210> 5807
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5807
gaagauggca t                                                            11


<210> 5808
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5808
gaagauggca                                                              10


<210> 5809
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5809
gaagauggc                                                                9


<210> 5810
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5810
gaagaugg                                                                 8


<210> 5811
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5811
aagauggcau uucuag                                                       16


<210> 5812
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5812
aagauggcau uucua                                                        15


<210> 5813
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5813
aagauggcau uuct                                                         14


<210> 5814
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5814
aagauggcau uuc                                                          13


<210> 5815
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5815
aagauggcau ut                                                           12


<210> 5816
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5816
aagauggcau t                                                            11


<210> 5817
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5817
aagauggcat                                                              10


<210> 5818
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5818
aagauggca                                                                9


<210> 5819
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5819
aagauggc                                                                 8


<210> 5820
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5820
agauggcauu ucuag                                                        15


<210> 5821
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5821
agauggcauu ucua                                                         14


<210> 5822
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5822
agauggcauu uct                                                          13


<210> 5823
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5823
agauggcauu uc                                                           12


<210> 5824
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5824
agauggcauu t                                                            11


<210> 5825
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5825
agauggcaut                                                              10


<210> 5826
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5826
agauggcat                                                                9


<210> 5827
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5827
agauggca                                                                 8


<210> 5828
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5828
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 5829
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5829
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 5830
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5830
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 5831
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5831
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 5832
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5832
cuccaacauc aaggaagaug gcauut                                            26


<210> 5833
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5833
cuccaacauc aaggaagaug gcaut                                             25


<210> 5834
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5834
cuccaacauc aaggaagaug gcat                                              24


<210> 5835
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5835
cuccaacauc aaggaagaug gca                                               23


<210> 5836
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5836
cuccaacauc aaggaagaug gc                                                22


<210> 5837
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5837
cuccaacauc aaggaagaug g                                                 21


<210> 5838
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5838
cuccaacauc aaggaagaug                                                   20


<210> 5839
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5839
cuccaacauc aaggaagat                                                    19


<210> 5840
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5840
cuccaacauc aaggaaga                                                     18


<210> 5841
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5841
cuccaacauc aaggaag                                                      17


<210> 5842
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5842
uccaacauca aggaagaugg cauuucuag                                         29


<210> 5843
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5843
uccaacauca aggaagaugg cauuucua                                          28


<210> 5844
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5844
uccaacauca aggaagaugg cauuuct                                           27


<210> 5845
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5845
uccaacauca aggaagaugg cauuuc                                            26


<210> 5846
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5846
uccaacauca aggaagaugg cauut                                             25


<210> 5847
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5847
uccaacauca aggaagaugg caut                                              24


<210> 5848
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5848
uccaacauca aggaagaugg cat                                               23


<210> 5849
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5849
uccaacauca aggaagaugg ca                                                22


<210> 5850
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5850
uccaacauca aggaagaugg c                                                 21


<210> 5851
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5851
uccaacauca aggaagaugg                                                   20


<210> 5852
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5852
uccaacauca aggaagaug                                                    19


<210> 5853
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5853
uccaacauca aggaagat                                                     18


<210> 5854
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5854
uccaacauca aggaaga                                                      17


<210> 5855
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5855
uccaacauca aggaag                                                       16


<210> 5856
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5856
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 5857
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5857
ccaacaucaa ggaagauggc auuucua                                           27


<210> 5858
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5858
ccaacaucaa ggaagauggc auuuct                                            26


<210> 5859
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5859
ccaacaucaa ggaagauggc auuuc                                             25


<210> 5860
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5860
ccaacaucaa ggaagauggc auut                                              24


<210> 5861
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5861
ccaacaucaa ggaagauggc aut                                               23


<210> 5862
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5862
ccaacaucaa ggaagauggc at                                                22


<210> 5863
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5863
ccaacaucaa ggaagauggc a                                                 21


<210> 5864
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5864
ccaacaucaa ggaagauggc                                                   20


<210> 5865
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5865
ccaacaucaa ggaagaugg                                                    19


<210> 5866
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5866
ccaacaucaa ggaagaug                                                     18


<210> 5867
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5867
ccaacaucaa ggaagat                                                      17


<210> 5868
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5868
ccaacaucaa ggaaga                                                       16


<210> 5869
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5869
ccaacaucaa ggaag                                                        15


<210> 5870
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5870
caacaucaag gaagauggca uuucuag                                           27


<210> 5871
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5871
caacaucaag gaagauggca uuucua                                            26


<210> 5872
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5872
caacaucaag gaagauggca uuuct                                             25


<210> 5873
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5873
caacaucaag gaagauggca uuuc                                              24


<210> 5874
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5874
caacaucaag gaagauggca uut                                               23


<210> 5875
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5875
caacaucaag gaagauggca ut                                                22


<210> 5876
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5876
caacaucaag gaagauggca t                                                 21


<210> 5877
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5877
caacaucaag gaagauggca                                                   20


<210> 5878
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5878
caacaucaag gaagauggc                                                    19


<210> 5879
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5879
caacaucaag gaagaugg                                                     18


<210> 5880
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5880
caacaucaag gaagaug                                                      17


<210> 5881
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5881
caacaucaag gaagat                                                       16


<210> 5882
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5882
caacaucaag gaaga                                                        15


<210> 5883
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5883
caacaucaag gaag                                                         14


<210> 5884
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5884
aacaucaagg aagauggcau uucuag                                            26


<210> 5885
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5885
aacaucaagg aagauggcau uucua                                             25


<210> 5886
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5886
aacaucaagg aagauggcau uuct                                              24


<210> 5887
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5887
aacaucaagg aagauggcau uuc                                               23


<210> 5888
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5888
aacaucaagg aagauggcau ut                                                22


<210> 5889
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5889
aacaucaagg aagauggcau t                                                 21


<210> 5890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5890
aacaucaagg aagauggcat                                                   20


<210> 5891
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5891
aacaucaagg aagauggca                                                    19


<210> 5892
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5892
aacaucaagg aagauggc                                                     18


<210> 5893
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5893
aacaucaagg aagaugg                                                      17


<210> 5894
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5894
aacaucaagg aagaug                                                       16


<210> 5895
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5895
aacaucaagg aagat                                                        15


<210> 5896
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5896
aacaucaagg aaga                                                         14


<210> 5897
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5897
aacaucaagg aag                                                          13


<210> 5898
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5898
acaucaagga agauggcauu ucuag                                             25


<210> 5899
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5899
acaucaagga agauggcauu ucua                                              24


<210> 5900
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5900
acaucaagga agauggcauu uct                                               23


<210> 5901
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5901
acaucaagga agauggcauu uc                                                22


<210> 5902
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5902
acaucaagga agauggcauu t                                                 21


<210> 5903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5903
acaucaagga agauggcaut                                                   20


<210> 5904
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5904
acaucaagga agauggcat                                                    19


<210> 5905
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5905
acaucaagga agauggca                                                     18


<210> 5906
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5906
acaucaagga agauggc                                                      17


<210> 5907
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5907
acaucaagga agaugg                                                       16


<210> 5908
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5908
acaucaagga agaug                                                        15


<210> 5909
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5909
acaucaagga agat                                                         14


<210> 5910
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5910
acaucaagga aga                                                          13


<210> 5911
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5911
acaucaagga ag                                                           12


<210> 5912
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5912
caucaaggaa gauggcauuu cuag                                              24


<210> 5913
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5913
caucaaggaa gauggcauuu cua                                               23


<210> 5914
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5914
caucaaggaa gauggcauuu ct                                                22


<210> 5915
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5915
caucaaggaa gauggcauuu c                                                 21


<210> 5916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5916
caucaaggaa gauggcauut                                                   20


<210> 5917
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5917
caucaaggaa gauggcaut                                                    19


<210> 5918
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5918
caucaaggaa gauggcat                                                     18


<210> 5919
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5919
caucaaggaa gauggca                                                      17


<210> 5920
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5920
caucaaggaa gauggc                                                       16


<210> 5921
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5921
caucaaggaa gaugg                                                        15


<210> 5922
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5922
caucaaggaa gaug                                                         14


<210> 5923
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5923
caucaaggaa gat                                                          13


<210> 5924
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5924
caucaaggaa ga                                                           12


<210> 5925
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5925
caucaaggaa g                                                            11


<210> 5926
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5926
aucaaggaag auggcauuuc uag                                               23


<210> 5927
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5927
aucaaggaag auggcauuuc ua                                                22


<210> 5928
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5928
aucaaggaag auggcauuuc t                                                 21


<210> 5929
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5929
aucaaggaag auggcauuuc                                                   20


<210> 5930
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5930
aucaaggaag auggcauut                                                    19


<210> 5931
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5931
aucaaggaag auggcaut                                                     18


<210> 5932
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5932
aucaaggaag auggcat                                                      17


<210> 5933
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5933
aucaaggaag auggca                                                       16


<210> 5934
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5934
aucaaggaag auggc                                                        15


<210> 5935
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5935
aucaaggaag augg                                                         14


<210> 5936
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5936
aucaaggaag aug                                                          13


<210> 5937
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5937
aucaaggaag at                                                           12


<210> 5938
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5938
aucaaggaag a                                                            11


<210> 5939
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5939
aucaaggaag                                                              10


<210> 5940
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5940
ccagagcagg uaccuccaac auc                                               23


<210> 5941
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5941
ccagagcagg uaccucca                                                     18


<210> 5942
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5942
ccucugugau uuuauaacuu gat                                               23


<210> 5943
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5943
ucacccacca ucaccct                                                      17


<210> 5944
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5944
ugauauccuc aaggucaccc                                                   20


<210> 5945
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5945
cugcuugaug aucaucucgu ug                                                22


<210> 5946
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5946
cugcuugaug aucaucuc                                                     18


<210> 5947
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5947
guuuccuuag uaaccacag                                                    19


<210> 5948
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5948
guuuccuuag uaaccac                                                      17


<210> 5949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5949
ucaaggaaga uggcauuuct                                                   20


<210> 5950
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5950
ucaaggaaga uggcauuucu ag                                                22


<210> 5951
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5951
gguaaguucu guccaagc                                                     18


<210> 5952
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5952
guaaguucug uccaagcc                                                     18


<210> 5953
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5953
agucgguaag uucugucc                                                     18


<210> 5954
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5954
cuguccaagc ccgguuga                                                     18


<210> 5955
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5955
uaaguucugu ccaag                                                        15


<210> 5956
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5956
uucuguccaa gcccgguuga                                                   20


<210> 5957
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5957
uucuguccaa gcccgguug                                                    19


<210> 5958
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5958
uucuguccaa gcccggut                                                     18


<210> 5959
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5959
uucuguccaa gcccggt                                                      17


<210> 5960
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5960
uucuguccaa gcccgg                                                       16


<210> 5961
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5961
uucuguccaa gcccg                                                        15


<210> 5962
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5962
uucuguccaa gccc                                                         14


<210> 5963
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5963
uucuguccaa gcc                                                          13


<210> 5964
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5964
uucuguccaa gc                                                           12


<210> 5965
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5965
uucuguccaa g                                                            11


<210> 5966
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5966
uucuguccaa                                                              10


<210> 5967
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5967
uucugucca                                                                9


<210> 5968
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5968
uucugucc                                                                 8


<210> 5969
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5969
ucuguccaag cccgguuga                                                    19


<210> 5970
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5970
ucuguccaag cccgguug                                                     18


<210> 5971
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5971
ucuguccaag cccggut                                                      17


<210> 5972
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5972
ucuguccaag cccggt                                                       16


<210> 5973
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5973
ucuguccaag cccgg                                                        15


<210> 5974
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5974
ucuguccaag cccg                                                         14


<210> 5975
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5975
ucuguccaag ccc                                                          13


<210> 5976
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5976
ucuguccaag cc                                                           12


<210> 5977
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5977
ucuguccaag c                                                            11


<210> 5978
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5978
ucuguccaag                                                              10


<210> 5979
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5979
ucuguccaa                                                                9


<210> 5980
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5980
ucugucca                                                                 8


<210> 5981
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5981
cuguccaagc ccgguug                                                      17


<210> 5982
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5982
cuguccaagc ccggut                                                       16


<210> 5983
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5983
cuguccaagc ccggt                                                        15


<210> 5984
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5984
cuguccaagc ccgg                                                         14


<210> 5985
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5985
cuguccaagc ccg                                                          13


<210> 5986
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5986
cuguccaagc cc                                                           12


<210> 5987
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5987
cuguccaagc c                                                            11


<210> 5988
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5988
cuguccaagc                                                              10


<210> 5989
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5989
cuguccaag                                                                9


<210> 5990
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5990
cuguccaa                                                                 8


<210> 5991
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5991
guucugucca agcccgguug                                                   20


<210> 5992
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5992
guucugucca agcccggut                                                    19


<210> 5993
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5993
guucugucca agcccggt                                                     18


<210> 5994
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5994
guucugucca agcccgg                                                      17


<210> 5995
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5995
guucugucca agcccg                                                       16


<210> 5996
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5996
guucugucca agccc                                                        15


<210> 5997
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5997
guucugucca agcc                                                         14


<210> 5998
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5998
guucugucca agc                                                          13


<210> 5999
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 5999
guucugucca ag                                                           12


<210> 6000
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6000
guucugucca a                                                            11


<210> 6001
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6001
guucugucca                                                              10


<210> 6002
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6002
guucugucc                                                                9


<210> 6003
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6003
guucuguc                                                                 8


<210> 6004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6004
aguucugucc aagcccggut                                                   20


<210> 6005
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6005
aguucugucc aagcccggt                                                    19


<210> 6006
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6006
aguucugucc aagcccgg                                                     18


<210> 6007
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6007
aguucugucc aagcccg                                                      17


<210> 6008
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6008
aguucugucc aagccc                                                       16


<210> 6009
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6009
aguucugucc aagcc                                                        15


<210> 6010
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6010
aguucugucc aagc                                                         14


<210> 6011
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6011
aguucugucc aag                                                          13


<210> 6012
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6012
aguucugucc aa                                                           12


<210> 6013
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6013
aguucugucc a                                                            11


<210> 6014
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6014
aguucugucc                                                              10


<210> 6015
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6015
aguucuguc                                                                9


<210> 6016
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6016
aguucugt                                                                 8


<210> 6017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6017
aaguucuguc caagcccggt                                                   20


<210> 6018
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6018
aaguucuguc caagcccgg                                                    19


<210> 6019
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6019
aaguucuguc caagcccg                                                     18


<210> 6020
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6020
aaguucuguc caagccc                                                      17


<210> 6021
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6021
aaguucuguc caagcc                                                       16


<210> 6022
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6022
aaguucuguc caagc                                                        15


<210> 6023
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6023
aaguucuguc caag                                                         14


<210> 6024
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6024
aaguucuguc caa                                                          13


<210> 6025
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6025
aaguucuguc ca                                                           12


<210> 6026
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6026
aaguucuguc c                                                            11


<210> 6027
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6027
aaguucuguc                                                              10


<210> 6028
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6028
aaguucugt                                                                9


<210> 6029
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6029
aaguucug                                                                 8


<210> 6030
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6030
uaaguucugu ccaagcccgg                                                   20


<210> 6031
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6031
uaaguucugu ccaagcccg                                                    19


<210> 6032
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6032
uaaguucugu ccaagccc                                                     18


<210> 6033
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6033
uaaguucugu ccaagcc                                                      17


<210> 6034
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6034
uaaguucugu ccaagc                                                       16


<210> 6035
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6035
uaaguucugu ccaa                                                         14


<210> 6036
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6036
uaaguucugu cca                                                          13


<210> 6037
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6037
uaaguucugu cc                                                           12


<210> 6038
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6038
uaaguucugu c                                                            11


<210> 6039
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6039
uaaguucugt                                                              10


<210> 6040
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6040
uaaguucug                                                                9


<210> 6041
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6041
uaaguuct                                                                 8


<210> 6042
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6042
guaaguucug uccaagcccg                                                   20


<210> 6043
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6043
guaaguucug uccaagccc                                                    19


<210> 6044
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6044
guaaguucug uccaagc                                                      17


<210> 6045
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6045
guaaguucug uccaag                                                       16


<210> 6046
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6046
guaaguucug uccaa                                                        15


<210> 6047
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6047
guaaguucug ucca                                                         14


<210> 6048
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6048
guaaguucug ucc                                                          13


<210> 6049
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6049
guaaguucug uc                                                           12


<210> 6050
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6050
guaaguucug t                                                            11


<210> 6051
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6051
guaaguucug                                                              10


<210> 6052
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6052
guaaguuct                                                                9


<210> 6053
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6053
guaaguuc                                                                 8


<210> 6054
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6054
gguaaguucu guccaagccc                                                   20


<210> 6055
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6055
gguaaguucu guccaagcc                                                    19


<210> 6056
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6056
gguaaguucu guccaag                                                      17


<210> 6057
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6057
gguaaguucu guccaa                                                       16


<210> 6058
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6058
gguaaguucu gucca                                                        15


<210> 6059
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6059
gguaaguucu gucc                                                         14


<210> 6060
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6060
gguaaguucu guc                                                          13


<210> 6061
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6061
gguaaguucu gt                                                           12


<210> 6062
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6062
gguaaguucu g                                                            11


<210> 6063
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6063
gguaaguuct                                                              10


<210> 6064
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6064
gguaaguuc                                                                9


<210> 6065
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6065
gguaagut                                                                 8


<210> 6066
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6066
cgguaaguuc uguccaagcc                                                   20


<210> 6067
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6067
cgguaaguuc uguccaagc                                                    19


<210> 6068
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6068
cgguaaguuc uguccaag                                                     18


<210> 6069
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6069
cgguaaguuc uguccaa                                                      17


<210> 6070
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6070
cgguaaguuc ugucca                                                       16


<210> 6071
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6071
cgguaaguuc ugucc                                                        15


<210> 6072
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6072
cgguaaguuc uguc                                                         14


<210> 6073
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6073
cgguaaguuc ugt                                                          13


<210> 6074
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6074
cgguaaguuc ug                                                           12


<210> 6075
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6075
cgguaaguuc t                                                            11


<210> 6076
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6076
cgguaaguuc                                                              10


<210> 6077
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6077
cgguaagut                                                                9


<210> 6078
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6078
cgguaagt                                                                 8


<210> 6079
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6079
ucgguaaguu cuguccaagc                                                   20


<210> 6080
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6080
ucgguaaguu cuguccaag                                                    19


<210> 6081
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6081
ucgguaaguu cuguccaa                                                     18


<210> 6082
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6082
ucgguaaguu cugucca                                                      17


<210> 6083
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6083
ucgguaaguu cugucc                                                       16


<210> 6084
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6084
ucgguaaguu cuguc                                                        15


<210> 6085
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6085
ucgguaaguu cugt                                                         14


<210> 6086
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6086
ucgguaaguu cug                                                          13


<210> 6087
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6087
ucgguaaguu ct                                                           12


<210> 6088
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6088
ucgguaaguu c                                                            11


<210> 6089
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6089
ucgguaagut                                                              10


<210> 6090
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6090
ucgguaagt                                                                9


<210> 6091
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6091
gucgguaagu ucuguccaag                                                   20


<210> 6092
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6092
gucgguaagu ucuguccaa                                                    19


<210> 6093
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6093
gucgguaagu ucugucca                                                     18


<210> 6094
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6094
gucgguaagu ucugucc                                                      17


<210> 6095
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6095
gucgguaagu ucuguc                                                       16


<210> 6096
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6096
gucgguaagu ucugt                                                        15


<210> 6097
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6097
gucgguaagu ucug                                                         14


<210> 6098
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6098
gucgguaagu uct                                                          13


<210> 6099
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6099
gucgguaagu uc                                                           12


<210> 6100
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6100
gucgguaagu t                                                            11


<210> 6101
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6101
gucgguaagt                                                              10


<210> 6102
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6102
agucgguaag uucuguccaa                                                   20


<210> 6103
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6103
agucgguaag uucugucca                                                    19


<210> 6104
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6104
agucgguaag uucuguc                                                      17


<210> 6105
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6105
agucgguaag uucugt                                                       16


<210> 6106
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6106
agucgguaag uucug                                                        15


<210> 6107
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6107
agucgguaag uuct                                                         14


<210> 6108
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6108
agucgguaag uuc                                                          13


<210> 6109
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6109
agucgguaag ut                                                           12


<210> 6110
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6110
agucgguaag t                                                            11


<210> 6111
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6111
cagucgguaa guucugucca                                                   20


<210> 6112
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6112
cagucgguaa guucugucc                                                    19


<210> 6113
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6113
cagucgguaa guucuguc                                                     18


<210> 6114
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6114
cagucgguaa guucugt                                                      17


<210> 6115
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6115
cagucgguaa guucug                                                       16


<210> 6116
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6116
cagucgguaa guuct                                                        15


<210> 6117
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6117
cagucgguaa guuc                                                         14


<210> 6118
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6118
cagucgguaa gut                                                          13


<210> 6119
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6119
cagucgguaa gt                                                           12


<210> 6120
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6120
ccagucggua aguucugucc                                                   20


<210> 6121
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6121
ccagucggua aguucuguc                                                    19


<210> 6122
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6122
ccagucggua aguucugt                                                     18


<210> 6123
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6123
ccagucggua aguucug                                                      17


<210> 6124
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6124
ccagucggua aguuct                                                       16


<210> 6125
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6125
ccagucggua aguuc                                                        15


<210> 6126
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6126
ccagucggua agut                                                         14


<210> 6127
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6127
ccagucggua agt                                                          13


<210> 6128
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6128
gccagucggu aaguucuguc                                                   20


<210> 6129
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6129
gccagucggu aaguucugt                                                    19


<210> 6130
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6130
gccagucggu aaguucug                                                     18


<210> 6131
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6131
gccagucggu aaguuct                                                      17


<210> 6132
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6132
gccagucggu aaguuc                                                       16


<210> 6133
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6133
gccagucggu aagut                                                        15


<210> 6134
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6134
gccagucggu aagt                                                         14


<210> 6135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6135
ucaaggaaga uggcauuuct                                                   20


<210> 6136
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6136
ucaaggaaga uggcauuucu ag                                                22


<210> 6137
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6137
ucaaggaaga uggcat                                                       16


<210> 6138
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6138
gaagauggca uuuct                                                        15


<210> 6139
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6139
ucaaggaaga uggcauuucu a                                                 21


<210> 6140
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6140
ucaaggaaga uggcauuuc                                                    19


<210> 6141
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6141
ucaaggaaga uggcauut                                                     18


<210> 6142
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6142
ucaaggaaga uggcaut                                                      17


<210> 6143
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6143
ucaaggaaga uggca                                                        15


<210> 6144
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6144
ucaaggaaga uggc                                                         14


<210> 6145
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6145
ucaaggaaga ugg                                                          13


<210> 6146
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6146
ucaaggaaga ug                                                           12


<210> 6147
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6147
ucaaggaaga t                                                            11


<210> 6148
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6148
ucaaggaaga                                                              10


<210> 6149
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6149
ucaaggaag                                                                9


<210> 6150
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6150
caaggaagau ggcauuucua g                                                 21


<210> 6151
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6151
caaggaagau ggcauuucua                                                   20


<210> 6152
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6152
caaggaagau ggcauuuct                                                    19


<210> 6153
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6153
caaggaagau ggcauuuc                                                     18


<210> 6154
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6154
caaggaagau ggcauut                                                      17


<210> 6155
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6155
caaggaagau ggcaut                                                       16


<210> 6156
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6156
caaggaagau ggcat                                                        15


<210> 6157
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6157
caaggaagau ggca                                                         14


<210> 6158
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6158
caaggaagau ggc                                                          13


<210> 6159
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6159
caaggaagau gg                                                           12


<210> 6160
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6160
caaggaagau g                                                            11


<210> 6161
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6161
caaggaagat                                                              10


<210> 6162
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6162
caaggaaga                                                                9


<210> 6163
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6163
caaggaag                                                                 8


<210> 6164
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6164
aaggaagaug gcauuucuag                                                   20


<210> 6165
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6165
aaggaagaug gcauuucua                                                    19


<210> 6166
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6166
aaggaagaug gcauuuct                                                     18


<210> 6167
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6167
aaggaagaug gcauuuc                                                      17


<210> 6168
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6168
aaggaagaug gcauut                                                       16


<210> 6169
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6169
aaggaagaug gcaut                                                        15


<210> 6170
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6170
aaggaagaug gcat                                                         14


<210> 6171
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6171
aaggaagaug gca                                                          13


<210> 6172
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6172
aaggaagaug gc                                                           12


<210> 6173
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6173
aaggaagaug g                                                            11


<210> 6174
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6174
aaggaagaug                                                              10


<210> 6175
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6175
aaggaagat                                                                9


<210> 6176
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6176
aaggaaga                                                                 8


<210> 6177
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6177
aggaagaugg cauuucuag                                                    19


<210> 6178
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6178
aggaagaugg cauuucua                                                     18


<210> 6179
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6179
aggaagaugg cauuuct                                                      17


<210> 6180
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6180
aggaagaugg cauuuc                                                       16


<210> 6181
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6181
aggaagaugg cauut                                                        15


<210> 6182
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6182
aggaagaugg caut                                                         14


<210> 6183
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6183
aggaagaugg cat                                                          13


<210> 6184
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6184
aggaagaugg ca                                                           12


<210> 6185
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6185
aggaagaugg                                                              10


<210> 6186
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6186
aggaagaug                                                                9


<210> 6187
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6187
aggaagat                                                                 8


<210> 6188
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6188
ggaagauggc auuucuag                                                     18


<210> 6189
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6189
ggaagauggc auuucua                                                      17


<210> 6190
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6190
ggaagauggc auuuct                                                       16


<210> 6191
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6191
ggaagauggc auuuc                                                        15


<210> 6192
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6192
ggaagauggc auut                                                         14


<210> 6193
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6193
ggaagauggc aut                                                          13


<210> 6194
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6194
ggaagauggc at                                                           12


<210> 6195
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6195
ggaagauggc a                                                            11


<210> 6196
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6196
ggaagauggc                                                              10


<210> 6197
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6197
ggaagaug                                                                 8


<210> 6198
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6198
gaagauggca uuucuag                                                      17


<210> 6199
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6199
gaagauggca uuucua                                                       16


<210> 6200
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6200
gaagauggca uuuc                                                         14


<210> 6201
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6201
gaagauggca uut                                                          13


<210> 6202
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6202
gaagauggca ut                                                           12


<210> 6203
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6203
gaagauggca t                                                            11


<210> 6204
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6204
gaagauggca                                                              10


<210> 6205
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6205
gaagauggc                                                                9


<210> 6206
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6206
gaagaugg                                                                 8


<210> 6207
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6207
aagauggcau uucuag                                                       16


<210> 6208
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6208
aagauggcau uucua                                                        15


<210> 6209
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6209
aagauggcau uuct                                                         14


<210> 6210
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6210
aagauggcau uuc                                                          13


<210> 6211
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6211
aagauggcau ut                                                           12


<210> 6212
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6212
aagauggcau t                                                            11


<210> 6213
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6213
aagauggcat                                                              10


<210> 6214
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6214
aagauggca                                                                9


<210> 6215
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6215
aagauggc                                                                 8


<210> 6216
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6216
agauggcauu ucuag                                                        15


<210> 6217
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6217
agauggcauu ucua                                                         14


<210> 6218
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6218
agauggcauu uct                                                          13


<210> 6219
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6219
agauggcauu uc                                                           12


<210> 6220
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6220
agauggcauu t                                                            11


<210> 6221
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6221
agauggcaut                                                              10


<210> 6222
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6222
agauggcat                                                                9


<210> 6223
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6223
agauggca                                                                 8


<210> 6224
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6224
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 6225
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6225
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 6226
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6226
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 6227
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6227
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 6228
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6228
cuccaacauc aaggaagaug gcauut                                            26


<210> 6229
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6229
cuccaacauc aaggaagaug gcaut                                             25


<210> 6230
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6230
cuccaacauc aaggaagaug gcat                                              24


<210> 6231
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6231
cuccaacauc aaggaagaug gca                                               23


<210> 6232
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6232
cuccaacauc aaggaagaug gc                                                22


<210> 6233
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6233
cuccaacauc aaggaagaug g                                                 21


<210> 6234
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6234
cuccaacauc aaggaagaug                                                   20


<210> 6235
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6235
cuccaacauc aaggaagat                                                    19


<210> 6236
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6236
cuccaacauc aaggaaga                                                     18


<210> 6237
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6237
cuccaacauc aaggaag                                                      17


<210> 6238
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6238
uccaacauca aggaagaugg cauuucuag                                         29


<210> 6239
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6239
uccaacauca aggaagaugg cauuucua                                          28


<210> 6240
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6240
uccaacauca aggaagaugg cauuuct                                           27


<210> 6241
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6241
uccaacauca aggaagaugg cauuuc                                            26


<210> 6242
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6242
uccaacauca aggaagaugg cauut                                             25


<210> 6243
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6243
uccaacauca aggaagaugg caut                                              24


<210> 6244
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6244
uccaacauca aggaagaugg cat                                               23


<210> 6245
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6245
uccaacauca aggaagaugg ca                                                22


<210> 6246
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6246
uccaacauca aggaagaugg c                                                 21


<210> 6247
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6247
uccaacauca aggaagaugg                                                   20


<210> 6248
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6248
uccaacauca aggaagaug                                                    19


<210> 6249
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6249
uccaacauca aggaagat                                                     18


<210> 6250
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6250
uccaacauca aggaaga                                                      17


<210> 6251
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6251
uccaacauca aggaag                                                       16


<210> 6252
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6252
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 6253
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6253
ccaacaucaa ggaagauggc auuucua                                           27


<210> 6254
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6254
ccaacaucaa ggaagauggc auuuct                                            26


<210> 6255
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6255
ccaacaucaa ggaagauggc auuuc                                             25


<210> 6256
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6256
ccaacaucaa ggaagauggc auut                                              24


<210> 6257
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6257
ccaacaucaa ggaagauggc aut                                               23


<210> 6258
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6258
ccaacaucaa ggaagauggc at                                                22


<210> 6259
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6259
ccaacaucaa ggaagauggc a                                                 21


<210> 6260
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6260
ccaacaucaa ggaagauggc                                                   20


<210> 6261
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6261
ccaacaucaa ggaagaugg                                                    19


<210> 6262
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6262
ccaacaucaa ggaagaug                                                     18


<210> 6263
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6263
ccaacaucaa ggaagat                                                      17


<210> 6264
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6264
ccaacaucaa ggaaga                                                       16


<210> 6265
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6265
ccaacaucaa ggaag                                                        15


<210> 6266
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6266
caacaucaag gaagauggca uuucuag                                           27


<210> 6267
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6267
caacaucaag gaagauggca uuucua                                            26


<210> 6268
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6268
caacaucaag gaagauggca uuuct                                             25


<210> 6269
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6269
caacaucaag gaagauggca uuuc                                              24


<210> 6270
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6270
caacaucaag gaagauggca uut                                               23


<210> 6271
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6271
caacaucaag gaagauggca ut                                                22


<210> 6272
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6272
caacaucaag gaagauggca t                                                 21


<210> 6273
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6273
caacaucaag gaagauggca                                                   20


<210> 6274
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6274
caacaucaag gaagauggc                                                    19


<210> 6275
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6275
caacaucaag gaagaugg                                                     18


<210> 6276
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6276
caacaucaag gaagaug                                                      17


<210> 6277
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6277
caacaucaag gaagat                                                       16


<210> 6278
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6278
caacaucaag gaaga                                                        15


<210> 6279
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6279
caacaucaag gaag                                                         14


<210> 6280
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6280
aacaucaagg aagauggcau uucuag                                            26


<210> 6281
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6281
aacaucaagg aagauggcau uucua                                             25


<210> 6282
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6282
aacaucaagg aagauggcau uuct                                              24


<210> 6283
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6283
aacaucaagg aagauggcau uuc                                               23


<210> 6284
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6284
aacaucaagg aagauggcau ut                                                22


<210> 6285
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6285
aacaucaagg aagauggcau t                                                 21


<210> 6286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6286
aacaucaagg aagauggcat                                                   20


<210> 6287
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6287
aacaucaagg aagauggca                                                    19


<210> 6288
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6288
aacaucaagg aagauggc                                                     18


<210> 6289
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6289
aacaucaagg aagaugg                                                      17


<210> 6290
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6290
aacaucaagg aagaug                                                       16


<210> 6291
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6291
aacaucaagg aagat                                                        15


<210> 6292
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6292
aacaucaagg aaga                                                         14


<210> 6293
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6293
aacaucaagg aag                                                          13


<210> 6294
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6294
acaucaagga agauggcauu ucuag                                             25


<210> 6295
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6295
acaucaagga agauggcauu ucua                                              24


<210> 6296
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6296
acaucaagga agauggcauu uct                                               23


<210> 6297
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6297
acaucaagga agauggcauu uc                                                22


<210> 6298
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6298
acaucaagga agauggcauu t                                                 21


<210> 6299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6299
acaucaagga agauggcaut                                                   20


<210> 6300
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6300
acaucaagga agauggcat                                                    19


<210> 6301
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6301
acaucaagga agauggca                                                     18


<210> 6302
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6302
acaucaagga agauggc                                                      17


<210> 6303
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6303
acaucaagga agaugg                                                       16


<210> 6304
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6304
acaucaagga agaug                                                        15


<210> 6305
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6305
acaucaagga agat                                                         14


<210> 6306
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6306
acaucaagga aga                                                          13


<210> 6307
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6307
acaucaagga ag                                                           12


<210> 6308
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6308
caucaaggaa gauggcauuu cuag                                              24


<210> 6309
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6309
caucaaggaa gauggcauuu cua                                               23


<210> 6310
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6310
caucaaggaa gauggcauuu ct                                                22


<210> 6311
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6311
caucaaggaa gauggcauuu c                                                 21


<210> 6312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6312
caucaaggaa gauggcauut                                                   20


<210> 6313
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6313
caucaaggaa gauggcaut                                                    19


<210> 6314
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6314
caucaaggaa gauggcat                                                     18


<210> 6315
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6315
caucaaggaa gauggca                                                      17


<210> 6316
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6316
caucaaggaa gauggc                                                       16


<210> 6317
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6317
caucaaggaa gaugg                                                        15


<210> 6318
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6318
caucaaggaa gaug                                                         14


<210> 6319
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6319
caucaaggaa gat                                                          13


<210> 6320
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6320
caucaaggaa ga                                                           12


<210> 6321
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6321
caucaaggaa g                                                            11


<210> 6322
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6322
aucaaggaag auggcauuuc uag                                               23


<210> 6323
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6323
aucaaggaag auggcauuuc ua                                                22


<210> 6324
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6324
aucaaggaag auggcauuuc t                                                 21


<210> 6325
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6325
aucaaggaag auggcauuuc                                                   20


<210> 6326
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6326
aucaaggaag auggcauut                                                    19


<210> 6327
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6327
aucaaggaag auggcaut                                                     18


<210> 6328
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6328
aucaaggaag auggcat                                                      17


<210> 6329
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6329
aucaaggaag auggca                                                       16


<210> 6330
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6330
aucaaggaag auggc                                                        15


<210> 6331
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6331
aucaaggaag augg                                                         14


<210> 6332
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6332
aucaaggaag aug                                                          13


<210> 6333
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6333
aucaaggaag at                                                           12


<210> 6334
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6334
aucaaggaag a                                                            11


<210> 6335
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6335
aucaaggaag                                                              10


<210> 6336
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6336
ccagagcagg uaccuccaac auc                                               23


<210> 6337
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6337
ccagagcagg uaccucca                                                     18


<210> 6338
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6338
ccucugugau uuuauaacuu gat                                               23


<210> 6339
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6339
ucacccacca ucaccct                                                      17


<210> 6340
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6340
ugauauccuc aaggucaccc                                                   20


<210> 6341
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6341
cugcuugaug aucaucucgu ug                                                22


<210> 6342
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6342
cugcuugaug aucaucuc                                                     18


<210> 6343
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6343
guuuccuuag uaaccacag                                                    19


<210> 6344
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 6344
guuuccuuag uaaccac                                                      17


<210> 6345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6345
tcaaggaaga uggcauuuct                                                   20


<210> 6346
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6346
tcaaggaaga uggcauuucu ag                                                22


<210> 6347
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6347
gguaaguucu guccaagc                                                     18


<210> 6348
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6348
guaaguucug uccaagcc                                                     18


<210> 6349
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6349
agucgguaag uucugucc                                                     18


<210> 6350
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6350
cuguccaagc ccgguuga                                                     18


<210> 6351
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6351
taaguucugu ccaag                                                        15


<210> 6352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6352
tucuguccaa gcccgguuga                                                   20


<210> 6353
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6353
tucuguccaa gcccgguug                                                    19


<210> 6354
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6354
tucuguccaa gcccggut                                                     18


<210> 6355
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6355
tucuguccaa gcccggt                                                      17


<210> 6356
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6356
tucuguccaa gcccgg                                                       16


<210> 6357
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6357
tucuguccaa gcccg                                                        15


<210> 6358
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6358
tucuguccaa gccc                                                         14


<210> 6359
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6359
tucuguccaa gcc                                                          13


<210> 6360
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6360
tucuguccaa gc                                                           12


<210> 6361
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6361
tucuguccaa g                                                            11


<210> 6362
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6362
tucuguccaa                                                              10


<210> 6363
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6363
tucugucca                                                                9


<210> 6364
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6364
tucugucc                                                                 8


<210> 6365
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6365
tcuguccaag cccgguuga                                                    19


<210> 6366
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6366
tcuguccaag cccgguug                                                     18


<210> 6367
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6367
tcuguccaag cccggut                                                      17


<210> 6368
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6368
tcuguccaag cccggt                                                       16


<210> 6369
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6369
tcuguccaag cccgg                                                        15


<210> 6370
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6370
tcuguccaag cccg                                                         14


<210> 6371
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6371
tcuguccaag ccc                                                          13


<210> 6372
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6372
tcuguccaag cc                                                           12


<210> 6373
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6373
tcuguccaag c                                                            11


<210> 6374
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6374
tcuguccaag                                                              10


<210> 6375
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6375
tcuguccaa                                                                9


<210> 6376
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6376
tcugucca                                                                 8


<210> 6377
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6377
cuguccaagc ccgguug                                                      17


<210> 6378
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6378
cuguccaagc ccggut                                                       16


<210> 6379
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6379
cuguccaagc ccggt                                                        15


<210> 6380
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6380
cuguccaagc ccgg                                                         14


<210> 6381
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6381
cuguccaagc ccg                                                          13


<210> 6382
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6382
cuguccaagc cc                                                           12


<210> 6383
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6383
cuguccaagc c                                                            11


<210> 6384
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6384
cuguccaagc                                                              10


<210> 6385
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6385
cuguccaag                                                                9


<210> 6386
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6386
cuguccaa                                                                 8


<210> 6387
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6387
guucugucca agcccgguug                                                   20


<210> 6388
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6388
guucugucca agcccggut                                                    19


<210> 6389
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6389
guucugucca agcccggt                                                     18


<210> 6390
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6390
guucugucca agcccgg                                                      17


<210> 6391
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6391
guucugucca agcccg                                                       16


<210> 6392
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6392
guucugucca agccc                                                        15


<210> 6393
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6393
guucugucca agcc                                                         14


<210> 6394
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6394
guucugucca agc                                                          13


<210> 6395
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6395
guucugucca ag                                                           12


<210> 6396
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6396
guucugucca a                                                            11


<210> 6397
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6397
guucugucca                                                              10


<210> 6398
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6398
guucugucc                                                                9


<210> 6399
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6399
guucuguc                                                                 8


<210> 6400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6400
aguucugucc aagcccggut                                                   20


<210> 6401
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6401
aguucugucc aagcccggt                                                    19


<210> 6402
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6402
aguucugucc aagcccgg                                                     18


<210> 6403
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6403
aguucugucc aagcccg                                                      17


<210> 6404
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6404
aguucugucc aagccc                                                       16


<210> 6405
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6405
aguucugucc aagcc                                                        15


<210> 6406
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6406
aguucugucc aagc                                                         14


<210> 6407
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6407
aguucugucc aag                                                          13


<210> 6408
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6408
aguucugucc aa                                                           12


<210> 6409
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6409
aguucugucc a                                                            11


<210> 6410
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6410
aguucugucc                                                              10


<210> 6411
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6411
aguucuguc                                                                9


<210> 6412
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6412
aguucugt                                                                 8


<210> 6413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6413
aaguucuguc caagcccggt                                                   20


<210> 6414
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6414
aaguucuguc caagcccgg                                                    19


<210> 6415
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6415
aaguucuguc caagcccg                                                     18


<210> 6416
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6416
aaguucuguc caagccc                                                      17


<210> 6417
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6417
aaguucuguc caagcc                                                       16


<210> 6418
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6418
aaguucuguc caagc                                                        15


<210> 6419
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6419
aaguucuguc caag                                                         14


<210> 6420
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6420
aaguucuguc caa                                                          13


<210> 6421
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6421
aaguucuguc ca                                                           12


<210> 6422
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6422
aaguucuguc c                                                            11


<210> 6423
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6423
aaguucuguc                                                              10


<210> 6424
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6424
aaguucugt                                                                9


<210> 6425
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6425
aaguucug                                                                 8


<210> 6426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6426
taaguucugu ccaagcccgg                                                   20


<210> 6427
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6427
taaguucugu ccaagcccg                                                    19


<210> 6428
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6428
taaguucugu ccaagccc                                                     18


<210> 6429
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6429
taaguucugu ccaagcc                                                      17


<210> 6430
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6430
taaguucugu ccaagc                                                       16


<210> 6431
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6431
taaguucugu ccaa                                                         14


<210> 6432
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6432
taaguucugu cca                                                          13


<210> 6433
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6433
taaguucugu cc                                                           12


<210> 6434
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6434
taaguucugu c                                                            11


<210> 6435
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6435
taaguucugt                                                              10


<210> 6436
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6436
taaguucug                                                                9


<210> 6437
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6437
taaguuct                                                                 8


<210> 6438
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6438
guaaguucug uccaagcccg                                                   20


<210> 6439
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6439
guaaguucug uccaagccc                                                    19


<210> 6440
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6440
guaaguucug uccaagc                                                      17


<210> 6441
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6441
guaaguucug uccaag                                                       16


<210> 6442
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6442
guaaguucug uccaa                                                        15


<210> 6443
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6443
guaaguucug ucca                                                         14


<210> 6444
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6444
guaaguucug ucc                                                          13


<210> 6445
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6445
guaaguucug uc                                                           12


<210> 6446
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6446
guaaguucug t                                                            11


<210> 6447
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6447
guaaguucug                                                              10


<210> 6448
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6448
guaaguuct                                                                9


<210> 6449
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6449
guaaguuc                                                                 8


<210> 6450
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6450
gguaaguucu guccaagccc                                                   20


<210> 6451
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6451
gguaaguucu guccaagcc                                                    19


<210> 6452
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6452
gguaaguucu guccaag                                                      17


<210> 6453
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6453
gguaaguucu guccaa                                                       16


<210> 6454
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6454
gguaaguucu gucca                                                        15


<210> 6455
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6455
gguaaguucu gucc                                                         14


<210> 6456
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6456
gguaaguucu guc                                                          13


<210> 6457
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6457
gguaaguucu gt                                                           12


<210> 6458
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6458
gguaaguucu g                                                            11


<210> 6459
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6459
gguaaguuct                                                              10


<210> 6460
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6460
gguaaguuc                                                                9


<210> 6461
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6461
gguaagut                                                                 8


<210> 6462
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6462
cgguaaguuc uguccaagcc                                                   20


<210> 6463
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6463
cgguaaguuc uguccaagc                                                    19


<210> 6464
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6464
cgguaaguuc uguccaag                                                     18


<210> 6465
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6465
cgguaaguuc uguccaa                                                      17


<210> 6466
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6466
cgguaaguuc ugucca                                                       16


<210> 6467
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6467
cgguaaguuc ugucc                                                        15


<210> 6468
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6468
cgguaaguuc uguc                                                         14


<210> 6469
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6469
cgguaaguuc ugt                                                          13


<210> 6470
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6470
cgguaaguuc ug                                                           12


<210> 6471
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6471
cgguaaguuc t                                                            11


<210> 6472
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6472
cgguaaguuc                                                              10


<210> 6473
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6473
cgguaagut                                                                9


<210> 6474
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6474
cgguaagt                                                                 8


<210> 6475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6475
tcgguaaguu cuguccaagc                                                   20


<210> 6476
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6476
tcgguaaguu cuguccaag                                                    19


<210> 6477
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6477
tcgguaaguu cuguccaa                                                     18


<210> 6478
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6478
tcgguaaguu cugucca                                                      17


<210> 6479
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6479
tcgguaaguu cugucc                                                       16


<210> 6480
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6480
tcgguaaguu cuguc                                                        15


<210> 6481
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6481
tcgguaaguu cugt                                                         14


<210> 6482
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6482
tcgguaaguu cug                                                          13


<210> 6483
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6483
tcgguaaguu ct                                                           12


<210> 6484
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6484
tcgguaaguu c                                                            11


<210> 6485
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6485
tcgguaagut                                                              10


<210> 6486
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6486
tcgguaagt                                                                9


<210> 6487
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6487
gucgguaagu ucuguccaag                                                   20


<210> 6488
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6488
gucgguaagu ucuguccaa                                                    19


<210> 6489
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6489
gucgguaagu ucugucca                                                     18


<210> 6490
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6490
gucgguaagu ucugucc                                                      17


<210> 6491
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6491
gucgguaagu ucuguc                                                       16


<210> 6492
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6492
gucgguaagu ucugt                                                        15


<210> 6493
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6493
gucgguaagu ucug                                                         14


<210> 6494
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6494
gucgguaagu uct                                                          13


<210> 6495
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6495
gucgguaagu uc                                                           12


<210> 6496
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6496
gucgguaagu t                                                            11


<210> 6497
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6497
gucgguaagt                                                              10


<210> 6498
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6498
agucgguaag uucuguccaa                                                   20


<210> 6499
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6499
agucgguaag uucugucca                                                    19


<210> 6500
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6500
agucgguaag uucuguc                                                      17


<210> 6501
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6501
agucgguaag uucugt                                                       16


<210> 6502
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6502
agucgguaag uucug                                                        15


<210> 6503
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6503
agucgguaag uuct                                                         14


<210> 6504
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6504
agucgguaag uuc                                                          13


<210> 6505
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6505
agucgguaag ut                                                           12


<210> 6506
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6506
agucgguaag t                                                            11


<210> 6507
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6507
cagucgguaa guucugucca                                                   20


<210> 6508
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6508
cagucgguaa guucugucc                                                    19


<210> 6509
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6509
cagucgguaa guucuguc                                                     18


<210> 6510
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6510
cagucgguaa guucugt                                                      17


<210> 6511
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6511
cagucgguaa guucug                                                       16


<210> 6512
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6512
cagucgguaa guuct                                                        15


<210> 6513
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6513
cagucgguaa guuc                                                         14


<210> 6514
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6514
cagucgguaa gut                                                          13


<210> 6515
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6515
cagucgguaa gt                                                           12


<210> 6516
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6516
ccagucggua aguucugucc                                                   20


<210> 6517
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6517
ccagucggua aguucuguc                                                    19


<210> 6518
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6518
ccagucggua aguucugt                                                     18


<210> 6519
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6519
ccagucggua aguucug                                                      17


<210> 6520
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6520
ccagucggua aguuct                                                       16


<210> 6521
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6521
ccagucggua aguuc                                                        15


<210> 6522
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6522
ccagucggua agut                                                         14


<210> 6523
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6523
ccagucggua agt                                                          13


<210> 6524
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6524
gccagucggu aaguucuguc                                                   20


<210> 6525
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6525
gccagucggu aaguucugt                                                    19


<210> 6526
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6526
gccagucggu aaguucug                                                     18


<210> 6527
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6527
gccagucggu aaguuct                                                      17


<210> 6528
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6528
gccagucggu aaguuc                                                       16


<210> 6529
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6529
gccagucggu aagut                                                        15


<210> 6530
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6530
gccagucggu aagt                                                         14


<210> 6531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6531
tcaaggaaga uggcauuuct                                                   20


<210> 6532
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6532
tcaaggaaga uggcauuucu ag                                                22


<210> 6533
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6533
tcaaggaaga uggcat                                                       16


<210> 6534
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6534
gaagauggca uuuct                                                        15


<210> 6535
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6535
tcaaggaaga uggcauuucu a                                                 21


<210> 6536
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6536
tcaaggaaga uggcauuuc                                                    19


<210> 6537
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6537
tcaaggaaga uggcauut                                                     18


<210> 6538
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6538
tcaaggaaga uggcaut                                                      17


<210> 6539
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6539
tcaaggaaga uggca                                                        15


<210> 6540
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6540
tcaaggaaga uggc                                                         14


<210> 6541
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6541
tcaaggaaga ugg                                                          13


<210> 6542
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6542
tcaaggaaga ug                                                           12


<210> 6543
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6543
tcaaggaaga t                                                            11


<210> 6544
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6544
tcaaggaaga                                                              10


<210> 6545
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6545
tcaaggaag                                                                9


<210> 6546
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6546
caaggaagau ggcauuucua g                                                 21


<210> 6547
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6547
caaggaagau ggcauuucua                                                   20


<210> 6548
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6548
caaggaagau ggcauuuct                                                    19


<210> 6549
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6549
caaggaagau ggcauuuc                                                     18


<210> 6550
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6550
caaggaagau ggcauut                                                      17


<210> 6551
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6551
caaggaagau ggcaut                                                       16


<210> 6552
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6552
caaggaagau ggcat                                                        15


<210> 6553
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6553
caaggaagau ggca                                                         14


<210> 6554
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6554
caaggaagau ggc                                                          13


<210> 6555
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6555
caaggaagau gg                                                           12


<210> 6556
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6556
caaggaagau g                                                            11


<210> 6557
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6557
caaggaagat                                                              10


<210> 6558
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6558
caaggaaga                                                                9


<210> 6559
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6559
caaggaag                                                                 8


<210> 6560
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6560
aaggaagaug gcauuucuag                                                   20


<210> 6561
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6561
aaggaagaug gcauuucua                                                    19


<210> 6562
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6562
aaggaagaug gcauuuct                                                     18


<210> 6563
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6563
aaggaagaug gcauuuc                                                      17


<210> 6564
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6564
aaggaagaug gcauut                                                       16


<210> 6565
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6565
aaggaagaug gcaut                                                        15


<210> 6566
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6566
aaggaagaug gcat                                                         14


<210> 6567
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6567
aaggaagaug gca                                                          13


<210> 6568
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6568
aaggaagaug gc                                                           12


<210> 6569
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6569
aaggaagaug g                                                            11


<210> 6570
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6570
aaggaagaug                                                              10


<210> 6571
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6571
aaggaagat                                                                9


<210> 6572
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6572
aaggaaga                                                                 8


<210> 6573
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6573
aggaagaugg cauuucuag                                                    19


<210> 6574
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6574
aggaagaugg cauuucua                                                     18


<210> 6575
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6575
aggaagaugg cauuuct                                                      17


<210> 6576
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6576
aggaagaugg cauuuc                                                       16


<210> 6577
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6577
aggaagaugg cauut                                                        15


<210> 6578
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6578
aggaagaugg caut                                                         14


<210> 6579
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6579
aggaagaugg cat                                                          13


<210> 6580
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6580
aggaagaugg ca                                                           12


<210> 6581
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6581
aggaagaugg                                                              10


<210> 6582
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6582
aggaagaug                                                                9


<210> 6583
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6583
aggaagat                                                                 8


<210> 6584
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6584
ggaagauggc auuucuag                                                     18


<210> 6585
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6585
ggaagauggc auuucua                                                      17


<210> 6586
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6586
ggaagauggc auuuct                                                       16


<210> 6587
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6587
ggaagauggc auuuc                                                        15


<210> 6588
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6588
ggaagauggc auut                                                         14


<210> 6589
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6589
ggaagauggc aut                                                          13


<210> 6590
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6590
ggaagauggc at                                                           12


<210> 6591
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6591
ggaagauggc a                                                            11


<210> 6592
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6592
ggaagauggc                                                              10


<210> 6593
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6593
ggaagaug                                                                 8


<210> 6594
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6594
gaagauggca uuucuag                                                      17


<210> 6595
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6595
gaagauggca uuucua                                                       16


<210> 6596
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6596
gaagauggca uuuc                                                         14


<210> 6597
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6597
gaagauggca uut                                                          13


<210> 6598
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6598
gaagauggca ut                                                           12


<210> 6599
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6599
gaagauggca t                                                            11


<210> 6600
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6600
gaagauggca                                                              10


<210> 6601
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6601
gaagauggc                                                                9


<210> 6602
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6602
gaagaugg                                                                 8


<210> 6603
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6603
aagauggcau uucuag                                                       16


<210> 6604
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6604
aagauggcau uucua                                                        15


<210> 6605
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6605
aagauggcau uuct                                                         14


<210> 6606
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6606
aagauggcau uuc                                                          13


<210> 6607
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6607
aagauggcau ut                                                           12


<210> 6608
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6608
aagauggcau t                                                            11


<210> 6609
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6609
aagauggcat                                                              10


<210> 6610
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6610
aagauggca                                                                9


<210> 6611
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6611
aagauggc                                                                 8


<210> 6612
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6612
agauggcauu ucuag                                                        15


<210> 6613
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6613
agauggcauu ucua                                                         14


<210> 6614
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6614
agauggcauu uct                                                          13


<210> 6615
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6615
agauggcauu uc                                                           12


<210> 6616
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6616
agauggcauu t                                                            11


<210> 6617
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6617
agauggcaut                                                              10


<210> 6618
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6618
agauggcat                                                                9


<210> 6619
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6619
agauggca                                                                 8


<210> 6620
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 6620
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 6621
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 6621
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 6622
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 6622
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 6623
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 6623
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 6624
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 6624
cuccaacauc aaggaagaug gcauut                                            26


<210> 6625
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 6625
cuccaacauc aaggaagaug gcaut                                             25


<210> 6626
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 6626
cuccaacauc aaggaagaug gcat                                              24


<210> 6627
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 6627
cuccaacauc aaggaagaug gca                                               23


<210> 6628
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6628
cuccaacauc aaggaagaug gc                                                22


<210> 6629
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6629
cuccaacauc aaggaagaug g                                                 21


<210> 6630
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6630
cuccaacauc aaggaagaug                                                   20


<210> 6631
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6631
cuccaacauc aaggaagat                                                    19


<210> 6632
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6632
cuccaacauc aaggaaga                                                     18


<210> 6633
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6633
cuccaacauc aaggaag                                                      17


<210> 6634
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 6634
tccaacauca aggaagaugg cauuucuag                                         29


<210> 6635
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 6635
tccaacauca aggaagaugg cauuucua                                          28


<210> 6636
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 6636
tccaacauca aggaagaugg cauuuct                                           27


<210> 6637
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 6637
tccaacauca aggaagaugg cauuuc                                            26


<210> 6638
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 6638
tccaacauca aggaagaugg cauut                                             25


<210> 6639
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 6639
tccaacauca aggaagaugg caut                                              24


<210> 6640
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 6640
tccaacauca aggaagaugg cat                                               23


<210> 6641
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6641
tccaacauca aggaagaugg ca                                                22


<210> 6642
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6642
tccaacauca aggaagaugg c                                                 21


<210> 6643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6643
tccaacauca aggaagaugg                                                   20


<210> 6644
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6644
tccaacauca aggaagaug                                                    19


<210> 6645
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6645
tccaacauca aggaagat                                                     18


<210> 6646
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6646
tccaacauca aggaaga                                                      17


<210> 6647
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6647
tccaacauca aggaag                                                       16


<210> 6648
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 6648
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 6649
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 6649
ccaacaucaa ggaagauggc auuucua                                           27


<210> 6650
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 6650
ccaacaucaa ggaagauggc auuuct                                            26


<210> 6651
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 6651
ccaacaucaa ggaagauggc auuuc                                             25


<210> 6652
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 6652
ccaacaucaa ggaagauggc auut                                              24


<210> 6653
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 6653
ccaacaucaa ggaagauggc aut                                               23


<210> 6654
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6654
ccaacaucaa ggaagauggc at                                                22


<210> 6655
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6655
ccaacaucaa ggaagauggc a                                                 21


<210> 6656
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6656
ccaacaucaa ggaagauggc                                                   20


<210> 6657
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6657
ccaacaucaa ggaagaugg                                                    19


<210> 6658
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6658
ccaacaucaa ggaagaug                                                     18


<210> 6659
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6659
ccaacaucaa ggaagat                                                      17


<210> 6660
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6660
ccaacaucaa ggaaga                                                       16


<210> 6661
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6661
ccaacaucaa ggaag                                                        15


<210> 6662
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 6662
caacaucaag gaagauggca uuucuag                                           27


<210> 6663
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 6663
caacaucaag gaagauggca uuucua                                            26


<210> 6664
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 6664
caacaucaag gaagauggca uuuct                                             25


<210> 6665
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 6665
caacaucaag gaagauggca uuuc                                              24


<210> 6666
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 6666
caacaucaag gaagauggca uut                                               23


<210> 6667
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6667
caacaucaag gaagauggca ut                                                22


<210> 6668
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6668
caacaucaag gaagauggca t                                                 21


<210> 6669
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6669
caacaucaag gaagauggca                                                   20


<210> 6670
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6670
caacaucaag gaagauggc                                                    19


<210> 6671
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6671
caacaucaag gaagaugg                                                     18


<210> 6672
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6672
caacaucaag gaagaug                                                      17


<210> 6673
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6673
caacaucaag gaagat                                                       16


<210> 6674
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6674
caacaucaag gaaga                                                        15


<210> 6675
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6675
caacaucaag gaag                                                         14


<210> 6676
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 6676
aacaucaagg aagauggcau uucuag                                            26


<210> 6677
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 6677
aacaucaagg aagauggcau uucua                                             25


<210> 6678
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 6678
aacaucaagg aagauggcau uuct                                              24


<210> 6679
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 6679
aacaucaagg aagauggcau uuc                                               23


<210> 6680
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6680
aacaucaagg aagauggcau ut                                                22


<210> 6681
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6681
aacaucaagg aagauggcau t                                                 21


<210> 6682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6682
aacaucaagg aagauggcat                                                   20


<210> 6683
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6683
aacaucaagg aagauggca                                                    19


<210> 6684
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6684
aacaucaagg aagauggc                                                     18


<210> 6685
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6685
aacaucaagg aagaugg                                                      17


<210> 6686
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6686
aacaucaagg aagaug                                                       16


<210> 6687
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6687
aacaucaagg aagat                                                        15


<210> 6688
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6688
aacaucaagg aaga                                                         14


<210> 6689
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6689
aacaucaagg aag                                                          13


<210> 6690
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 6690
acaucaagga agauggcauu ucuag                                             25


<210> 6691
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 6691
acaucaagga agauggcauu ucua                                              24


<210> 6692
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 6692
acaucaagga agauggcauu uct                                               23


<210> 6693
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6693
acaucaagga agauggcauu uc                                                22


<210> 6694
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6694
acaucaagga agauggcauu t                                                 21


<210> 6695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6695
acaucaagga agauggcaut                                                   20


<210> 6696
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6696
acaucaagga agauggcat                                                    19


<210> 6697
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6697
acaucaagga agauggca                                                     18


<210> 6698
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6698
acaucaagga agauggc                                                      17


<210> 6699
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6699
acaucaagga agaugg                                                       16


<210> 6700
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6700
acaucaagga agaug                                                        15


<210> 6701
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6701
acaucaagga agat                                                         14


<210> 6702
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6702
acaucaagga aga                                                          13


<210> 6703
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6703
acaucaagga ag                                                           12


<210> 6704
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 6704
caucaaggaa gauggcauuu cuag                                              24


<210> 6705
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 6705
caucaaggaa gauggcauuu cua                                               23


<210> 6706
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6706
caucaaggaa gauggcauuu ct                                                22


<210> 6707
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6707
caucaaggaa gauggcauuu c                                                 21


<210> 6708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6708
caucaaggaa gauggcauut                                                   20


<210> 6709
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6709
caucaaggaa gauggcaut                                                    19


<210> 6710
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6710
caucaaggaa gauggcat                                                     18


<210> 6711
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6711
caucaaggaa gauggca                                                      17


<210> 6712
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6712
caucaaggaa gauggc                                                       16


<210> 6713
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6713
caucaaggaa gaugg                                                        15


<210> 6714
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6714
caucaaggaa gaug                                                         14


<210> 6715
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6715
caucaaggaa gat                                                          13


<210> 6716
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6716
caucaaggaa ga                                                           12


<210> 6717
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6717
caucaaggaa g                                                            11


<210> 6718
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 6718
aucaaggaag auggcauuuc uag                                               23


<210> 6719
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6719
aucaaggaag auggcauuuc ua                                                22


<210> 6720
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6720
aucaaggaag auggcauuuc t                                                 21


<210> 6721
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6721
aucaaggaag auggcauuuc                                                   20


<210> 6722
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6722
aucaaggaag auggcauut                                                    19


<210> 6723
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6723
aucaaggaag auggcaut                                                     18


<210> 6724
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6724
aucaaggaag auggcat                                                      17


<210> 6725
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6725
aucaaggaag auggca                                                       16


<210> 6726
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6726
aucaaggaag auggc                                                        15


<210> 6727
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6727
aucaaggaag augg                                                         14


<210> 6728
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6728
aucaaggaag aug                                                          13


<210> 6729
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6729
aucaaggaag at                                                           12


<210> 6730
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6730
aucaaggaag a                                                            11


<210> 6731
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6731
aucaaggaag                                                              10


<210> 6732
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 6732
ccagagcagg uaccuccaac auc                                               23


<210> 6733
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6733
ccagagcagg uaccucca                                                     18


<210> 6734
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 6734
ccucugugau uuuauaacuu gat                                               23


<210> 6735
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6735
tcacccacca ucaccct                                                      17


<210> 6736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6736
tgauauccuc aaggucaccc                                                   20


<210> 6737
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6737
cugcuugaug aucaucucgu ug                                                22


<210> 6738
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6738
cugcuugaug aucaucuc                                                     18


<210> 6739
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6739
guuuccuuag uaaccacag                                                    19


<210> 6740
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6740
guuuccuuag uaaccac                                                      17


<210> 6741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6741
tcaaggaaga uggcauuuct                                                   20


<210> 6742
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6742
tcaaggaaga uggcauuucu ag                                                22


<210> 6743
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6743
gguaaguucu guccaagc                                                     18


<210> 6744
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6744
guaaguucug uccaagcc                                                     18


<210> 6745
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6745
agucgguaag uucugucc                                                     18


<210> 6746
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6746
cuguccaagc ccgguuga                                                     18


<210> 6747
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6747
taaguucugu ccaag                                                        15


<210> 6748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6748
tucuguccaa gcccgguuga                                                   20


<210> 6749
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6749
tucuguccaa gcccgguug                                                    19


<210> 6750
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6750
tucuguccaa gcccggut                                                     18


<210> 6751
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6751
tucuguccaa gcccggt                                                      17


<210> 6752
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6752
tucuguccaa gcccgg                                                       16


<210> 6753
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6753
tucuguccaa gcccg                                                        15


<210> 6754
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6754
tucuguccaa gccc                                                         14


<210> 6755
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6755
tucuguccaa gcc                                                          13


<210> 6756
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6756
tucuguccaa gc                                                           12


<210> 6757
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6757
tucuguccaa g                                                            11


<210> 6758
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6758
tucuguccaa                                                              10


<210> 6759
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6759
tucugucca                                                                9


<210> 6760
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6760
tucugucc                                                                 8


<210> 6761
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6761
tcuguccaag cccgguuga                                                    19


<210> 6762
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6762
tcuguccaag cccgguug                                                     18


<210> 6763
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6763
tcuguccaag cccggut                                                      17


<210> 6764
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6764
tcuguccaag cccggt                                                       16


<210> 6765
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6765
tcuguccaag cccgg                                                        15


<210> 6766
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6766
tcuguccaag cccg                                                         14


<210> 6767
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6767
tcuguccaag ccc                                                          13


<210> 6768
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6768
tcuguccaag cc                                                           12


<210> 6769
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6769
tcuguccaag c                                                            11


<210> 6770
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6770
tcuguccaag                                                              10


<210> 6771
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6771
tcuguccaa                                                                9


<210> 6772
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6772
tcugucca                                                                 8


<210> 6773
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6773
cuguccaagc ccgguug                                                      17


<210> 6774
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6774
cuguccaagc ccggut                                                       16


<210> 6775
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6775
cuguccaagc ccggt                                                        15


<210> 6776
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6776
cuguccaagc ccgg                                                         14


<210> 6777
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6777
cuguccaagc ccg                                                          13


<210> 6778
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6778
cuguccaagc cc                                                           12


<210> 6779
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6779
cuguccaagc c                                                            11


<210> 6780
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6780
cuguccaagc                                                              10


<210> 6781
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6781
cuguccaag                                                                9


<210> 6782
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6782
cuguccaa                                                                 8


<210> 6783
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6783
guucugucca agcccgguug                                                   20


<210> 6784
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6784
guucugucca agcccggut                                                    19


<210> 6785
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6785
guucugucca agcccggt                                                     18


<210> 6786
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6786
guucugucca agcccgg                                                      17


<210> 6787
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6787
guucugucca agcccg                                                       16


<210> 6788
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6788
guucugucca agccc                                                        15


<210> 6789
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6789
guucugucca agcc                                                         14


<210> 6790
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6790
guucugucca agc                                                          13


<210> 6791
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6791
guucugucca ag                                                           12


<210> 6792
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6792
guucugucca a                                                            11


<210> 6793
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6793
guucugucca                                                              10


<210> 6794
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6794
guucugucc                                                                9


<210> 6795
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6795
guucuguc                                                                 8


<210> 6796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6796
aguucugucc aagcccggut                                                   20


<210> 6797
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6797
aguucugucc aagcccggt                                                    19


<210> 6798
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6798
aguucugucc aagcccgg                                                     18


<210> 6799
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6799
aguucugucc aagcccg                                                      17


<210> 6800
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6800
aguucugucc aagccc                                                       16


<210> 6801
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6801
aguucugucc aagcc                                                        15


<210> 6802
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6802
aguucugucc aagc                                                         14


<210> 6803
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6803
aguucugucc aag                                                          13


<210> 6804
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6804
aguucugucc aa                                                           12


<210> 6805
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6805
aguucugucc a                                                            11


<210> 6806
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6806
aguucugucc                                                              10


<210> 6807
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6807
aguucuguc                                                                9


<210> 6808
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6808
aguucugt                                                                 8


<210> 6809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6809
aaguucuguc caagcccggt                                                   20


<210> 6810
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6810
aaguucuguc caagcccgg                                                    19


<210> 6811
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6811
aaguucuguc caagcccg                                                     18


<210> 6812
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6812
aaguucuguc caagccc                                                      17


<210> 6813
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6813
aaguucuguc caagcc                                                       16


<210> 6814
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6814
aaguucuguc caagc                                                        15


<210> 6815
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6815
aaguucuguc caag                                                         14


<210> 6816
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6816
aaguucuguc caa                                                          13


<210> 6817
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6817
aaguucuguc ca                                                           12


<210> 6818
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6818
aaguucuguc c                                                            11


<210> 6819
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6819
aaguucuguc                                                              10


<210> 6820
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6820
aaguucugt                                                                9


<210> 6821
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6821
aaguucug                                                                 8


<210> 6822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6822
taaguucugu ccaagcccgg                                                   20


<210> 6823
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6823
taaguucugu ccaagcccg                                                    19


<210> 6824
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6824
taaguucugu ccaagccc                                                     18


<210> 6825
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6825
taaguucugu ccaagcc                                                      17


<210> 6826
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6826
taaguucugu ccaagc                                                       16


<210> 6827
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6827
taaguucugu ccaa                                                         14


<210> 6828
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6828
taaguucugu cca                                                          13


<210> 6829
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6829
taaguucugu cc                                                           12


<210> 6830
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6830
taaguucugu c                                                            11


<210> 6831
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6831
taaguucugt                                                              10


<210> 6832
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6832
taaguucug                                                                9


<210> 6833
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6833
taaguuct                                                                 8


<210> 6834
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6834
guaaguucug uccaagcccg                                                   20


<210> 6835
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6835
guaaguucug uccaagccc                                                    19


<210> 6836
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6836
guaaguucug uccaagc                                                      17


<210> 6837
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6837
guaaguucug uccaag                                                       16


<210> 6838
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6838
guaaguucug uccaa                                                        15


<210> 6839
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6839
guaaguucug ucca                                                         14


<210> 6840
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6840
guaaguucug ucc                                                          13


<210> 6841
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6841
guaaguucug uc                                                           12


<210> 6842
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6842
guaaguucug t                                                            11


<210> 6843
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6843
guaaguucug                                                              10


<210> 6844
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6844
guaaguuct                                                                9


<210> 6845
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6845
guaaguuc                                                                 8


<210> 6846
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6846
gguaaguucu guccaagccc                                                   20


<210> 6847
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6847
gguaaguucu guccaagcc                                                    19


<210> 6848
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6848
gguaaguucu guccaag                                                      17


<210> 6849
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6849
gguaaguucu guccaa                                                       16


<210> 6850
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6850
gguaaguucu gucca                                                        15


<210> 6851
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6851
gguaaguucu gucc                                                         14


<210> 6852
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6852
gguaaguucu guc                                                          13


<210> 6853
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6853
gguaaguucu gt                                                           12


<210> 6854
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6854
gguaaguucu g                                                            11


<210> 6855
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6855
gguaaguuct                                                              10


<210> 6856
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6856
gguaaguuc                                                                9


<210> 6857
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6857
gguaagut                                                                 8


<210> 6858
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6858
cgguaaguuc uguccaagcc                                                   20


<210> 6859
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6859
cgguaaguuc uguccaagc                                                    19


<210> 6860
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6860
cgguaaguuc uguccaag                                                     18


<210> 6861
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6861
cgguaaguuc uguccaa                                                      17


<210> 6862
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6862
cgguaaguuc ugucca                                                       16


<210> 6863
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6863
cgguaaguuc ugucc                                                        15


<210> 6864
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6864
cgguaaguuc uguc                                                         14


<210> 6865
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6865
cgguaaguuc ugt                                                          13


<210> 6866
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6866
cgguaaguuc ug                                                           12


<210> 6867
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6867
cgguaaguuc t                                                            11


<210> 6868
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6868
cgguaaguuc                                                              10


<210> 6869
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6869
cgguaagut                                                                9


<210> 6870
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6870
cgguaagt                                                                 8


<210> 6871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6871
tcgguaaguu cuguccaagc                                                   20


<210> 6872
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6872
tcgguaaguu cuguccaag                                                    19


<210> 6873
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6873
tcgguaaguu cuguccaa                                                     18


<210> 6874
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6874
tcgguaaguu cugucca                                                      17


<210> 6875
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6875
tcgguaaguu cugucc                                                       16


<210> 6876
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6876
tcgguaaguu cuguc                                                        15


<210> 6877
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6877
tcgguaaguu cugt                                                         14


<210> 6878
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6878
tcgguaaguu cug                                                          13


<210> 6879
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6879
tcgguaaguu ct                                                           12


<210> 6880
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6880
tcgguaaguu c                                                            11


<210> 6881
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6881
tcgguaagut                                                              10


<210> 6882
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6882
tcgguaagt                                                                9


<210> 6883
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6883
gucgguaagu ucuguccaag                                                   20


<210> 6884
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6884
gucgguaagu ucuguccaa                                                    19


<210> 6885
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6885
gucgguaagu ucugucca                                                     18


<210> 6886
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6886
gucgguaagu ucugucc                                                      17


<210> 6887
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6887
gucgguaagu ucuguc                                                       16


<210> 6888
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6888
gucgguaagu ucugt                                                        15


<210> 6889
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6889
gucgguaagu ucug                                                         14


<210> 6890
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6890
gucgguaagu uct                                                          13


<210> 6891
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6891
gucgguaagu uc                                                           12


<210> 6892
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6892
gucgguaagu t                                                            11


<210> 6893
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6893
gucgguaagt                                                              10


<210> 6894
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6894
agucgguaag uucuguccaa                                                   20


<210> 6895
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6895
agucgguaag uucugucca                                                    19


<210> 6896
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6896
agucgguaag uucuguc                                                      17


<210> 6897
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6897
agucgguaag uucugt                                                       16


<210> 6898
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6898
agucgguaag uucug                                                        15


<210> 6899
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6899
agucgguaag uuct                                                         14


<210> 6900
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6900
agucgguaag uuc                                                          13


<210> 6901
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6901
agucgguaag ut                                                           12


<210> 6902
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6902
agucgguaag t                                                            11


<210> 6903
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6903
cagucgguaa guucugucca                                                   20


<210> 6904
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6904
cagucgguaa guucugucc                                                    19


<210> 6905
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6905
cagucgguaa guucuguc                                                     18


<210> 6906
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6906
cagucgguaa guucugt                                                      17


<210> 6907
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6907
cagucgguaa guucug                                                       16


<210> 6908
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6908
cagucgguaa guuct                                                        15


<210> 6909
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6909
cagucgguaa guuc                                                         14


<210> 6910
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6910
cagucgguaa gut                                                          13


<210> 6911
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6911
cagucgguaa gt                                                           12


<210> 6912
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6912
ccagucggua aguucugucc                                                   20


<210> 6913
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6913
ccagucggua aguucuguc                                                    19


<210> 6914
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6914
ccagucggua aguucugt                                                     18


<210> 6915
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6915
ccagucggua aguucug                                                      17


<210> 6916
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6916
ccagucggua aguuct                                                       16


<210> 6917
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6917
ccagucggua aguuc                                                        15


<210> 6918
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6918
ccagucggua agut                                                         14


<210> 6919
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6919
ccagucggua agt                                                          13


<210> 6920
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6920
gccagucggu aaguucuguc                                                   20


<210> 6921
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6921
gccagucggu aaguucugt                                                    19


<210> 6922
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6922
gccagucggu aaguucug                                                     18


<210> 6923
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6923
gccagucggu aaguuct                                                      17


<210> 6924
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6924
gccagucggu aaguuc                                                       16


<210> 6925
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6925
gccagucggu aagut                                                        15


<210> 6926
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6926
gccagucggu aagt                                                         14


<210> 6927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6927
tcaaggaaga uggcauuuct                                                   20


<210> 6928
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 6928
tcaaggaaga uggcauuucu ag                                                22


<210> 6929
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6929
tcaaggaaga uggcat                                                       16


<210> 6930
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6930
gaagauggca uuuct                                                        15


<210> 6931
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6931
tcaaggaaga uggcauuucu a                                                 21


<210> 6932
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6932
tcaaggaaga uggcauuuc                                                    19


<210> 6933
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6933
tcaaggaaga uggcauut                                                     18


<210> 6934
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6934
tcaaggaaga uggcaut                                                      17


<210> 6935
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6935
tcaaggaaga uggca                                                        15


<210> 6936
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6936
tcaaggaaga uggc                                                         14


<210> 6937
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6937
tcaaggaaga ugg                                                          13


<210> 6938
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6938
tcaaggaaga ug                                                           12


<210> 6939
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6939
tcaaggaaga t                                                            11


<210> 6940
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6940
tcaaggaaga                                                              10


<210> 6941
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6941
tcaaggaag                                                                9


<210> 6942
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 6942
caaggaagau ggcauuucua g                                                 21


<210> 6943
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6943
caaggaagau ggcauuucua                                                   20


<210> 6944
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6944
caaggaagau ggcauuuct                                                    19


<210> 6945
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6945
caaggaagau ggcauuuc                                                     18


<210> 6946
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6946
caaggaagau ggcauut                                                      17


<210> 6947
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6947
caaggaagau ggcaut                                                       16


<210> 6948
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6948
caaggaagau ggcat                                                        15


<210> 6949
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6949
caaggaagau ggca                                                         14


<210> 6950
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6950
caaggaagau ggc                                                          13


<210> 6951
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6951
caaggaagau gg                                                           12


<210> 6952
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6952
caaggaagau g                                                            11


<210> 6953
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6953
caaggaagat                                                              10


<210> 6954
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6954
caaggaaga                                                                9


<210> 6955
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6955
caaggaag                                                                 8


<210> 6956
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 6956
aaggaagaug gcauuucuag                                                   20


<210> 6957
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6957
aaggaagaug gcauuucua                                                    19


<210> 6958
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6958
aaggaagaug gcauuuct                                                     18


<210> 6959
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6959
aaggaagaug gcauuuc                                                      17


<210> 6960
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6960
aaggaagaug gcauut                                                       16


<210> 6961
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6961
aaggaagaug gcaut                                                        15


<210> 6962
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6962
aaggaagaug gcat                                                         14


<210> 6963
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6963
aaggaagaug gca                                                          13


<210> 6964
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6964
aaggaagaug gc                                                           12


<210> 6965
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6965
aaggaagaug g                                                            11


<210> 6966
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6966
aaggaagaug                                                              10


<210> 6967
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6967
aaggaagat                                                                9


<210> 6968
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6968
aaggaaga                                                                 8


<210> 6969
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 6969
aggaagaugg cauuucuag                                                    19


<210> 6970
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6970
aggaagaugg cauuucua                                                     18


<210> 6971
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6971
aggaagaugg cauuuct                                                      17


<210> 6972
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6972
aggaagaugg cauuuc                                                       16


<210> 6973
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6973
aggaagaugg cauut                                                        15


<210> 6974
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6974
aggaagaugg caut                                                         14


<210> 6975
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6975
aggaagaugg cat                                                          13


<210> 6976
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6976
aggaagaugg ca                                                           12


<210> 6977
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6977
aggaagaugg                                                              10


<210> 6978
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6978
aggaagaug                                                                9


<210> 6979
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6979
aggaagat                                                                 8


<210> 6980
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 6980
ggaagauggc auuucuag                                                     18


<210> 6981
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6981
ggaagauggc auuucua                                                      17


<210> 6982
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6982
ggaagauggc auuuct                                                       16


<210> 6983
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 6983
ggaagauggc auuuc                                                        15


<210> 6984
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6984
ggaagauggc auut                                                         14


<210> 6985
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6985
ggaagauggc aut                                                          13


<210> 6986
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6986
ggaagauggc at                                                           12


<210> 6987
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6987
ggaagauggc a                                                            11


<210> 6988
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6988
ggaagauggc                                                              10


<210> 6989
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6989
ggaagaug                                                                 8


<210> 6990
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 6990
gaagauggca uuucuag                                                      17


<210> 6991
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6991
gaagauggca uuucua                                                       16


<210> 6992
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 6992
gaagauggca uuuc                                                         14


<210> 6993
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 6993
gaagauggca uut                                                          13


<210> 6994
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 6994
gaagauggca ut                                                           12


<210> 6995
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 6995
gaagauggca t                                                            11


<210> 6996
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 6996
gaagauggca                                                              10


<210> 6997
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 6997
gaagauggc                                                                9


<210> 6998
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 6998
gaagaugg                                                                 8


<210> 6999
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 6999
aagauggcau uucuag                                                       16


<210> 7000
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 7000
aagauggcau uucua                                                        15


<210> 7001
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 7001
aagauggcau uuct                                                         14


<210> 7002
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 7002
aagauggcau uuc                                                          13


<210> 7003
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 7003
aagauggcau ut                                                           12


<210> 7004
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 7004
aagauggcau t                                                            11


<210> 7005
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 7005
aagauggcat                                                              10


<210> 7006
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 7006
aagauggca                                                                9


<210> 7007
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 7007
aagauggc                                                                 8


<210> 7008
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 7008
agauggcauu ucuag                                                        15


<210> 7009
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 7009
agauggcauu ucua                                                         14


<210> 7010
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 7010
agauggcauu uct                                                          13


<210> 7011
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 7011
agauggcauu uc                                                           12


<210> 7012
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 7012
agauggcauu t                                                            11


<210> 7013
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 7013
agauggcaut                                                              10


<210> 7014
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 7014
agauggcat                                                                9


<210> 7015
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 7015
agauggca                                                                 8


<210> 7016
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 7016
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 7017
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 7017
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 7018
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 7018
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 7019
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 7019
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 7020
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 7020
cuccaacauc aaggaagaug gcauut                                            26


<210> 7021
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 7021
cuccaacauc aaggaagaug gcaut                                             25


<210> 7022
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 7022
cuccaacauc aaggaagaug gcat                                              24


<210> 7023
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 7023
cuccaacauc aaggaagaug gca                                               23


<210> 7024
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 7024
cuccaacauc aaggaagaug gc                                                22


<210> 7025
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 7025
cuccaacauc aaggaagaug g                                                 21


<210> 7026
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 7026
cuccaacauc aaggaagaug                                                   20


<210> 7027
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 7027
cuccaacauc aaggaagat                                                    19


<210> 7028
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 7028
cuccaacauc aaggaaga                                                     18


<210> 7029
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 7029
cuccaacauc aaggaag                                                      17


<210> 7030
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 7030
tccaacauca aggaagaugg cauuucuag                                         29


<210> 7031
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 7031
tccaacauca aggaagaugg cauuucua                                          28


<210> 7032
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 7032
tccaacauca aggaagaugg cauuuct                                           27


<210> 7033
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 7033
tccaacauca aggaagaugg cauuuc                                            26


<210> 7034
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 7034
tccaacauca aggaagaugg cauut                                             25


<210> 7035
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 7035
tccaacauca aggaagaugg caut                                              24


<210> 7036
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 7036
tccaacauca aggaagaugg cat                                               23


<210> 7037
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 7037
tccaacauca aggaagaugg ca                                                22


<210> 7038
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 7038
tccaacauca aggaagaugg c                                                 21


<210> 7039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 7039
tccaacauca aggaagaugg                                                   20


<210> 7040
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 7040
tccaacauca aggaagaug                                                    19


<210> 7041
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 7041
tccaacauca aggaagat                                                     18


<210> 7042
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 7042
tccaacauca aggaaga                                                      17


<210> 7043
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 7043
tccaacauca aggaag                                                       16


<210> 7044
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 7044
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 7045
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 7045
ccaacaucaa ggaagauggc auuucua                                           27


<210> 7046
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 7046
ccaacaucaa ggaagauggc auuuct                                            26


<210> 7047
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 7047
ccaacaucaa ggaagauggc auuuc                                             25


<210> 7048
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 7048
ccaacaucaa ggaagauggc auut                                              24


<210> 7049
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 7049
ccaacaucaa ggaagauggc aut                                               23


<210> 7050
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 7050
ccaacaucaa ggaagauggc at                                                22


<210> 7051
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 7051
ccaacaucaa ggaagauggc a                                                 21


<210> 7052
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 7052
ccaacaucaa ggaagauggc                                                   20


<210> 7053
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 7053
ccaacaucaa ggaagaugg                                                    19


<210> 7054
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 7054
ccaacaucaa ggaagaug                                                     18


<210> 7055
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 7055
ccaacaucaa ggaagat                                                      17


<210> 7056
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 7056
ccaacaucaa ggaaga                                                       16


<210> 7057
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 7057
ccaacaucaa ggaag                                                        15


<210> 7058
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 7058
caacaucaag gaagauggca uuucuag                                           27


<210> 7059
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 7059
caacaucaag gaagauggca uuucua                                            26


<210> 7060
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 7060
caacaucaag gaagauggca uuuct                                             25


<210> 7061
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 7061
caacaucaag gaagauggca uuuc                                              24


<210> 7062
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 7062
caacaucaag gaagauggca uut                                               23


<210> 7063
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 7063
caacaucaag gaagauggca ut                                                22


<210> 7064
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 7064
caacaucaag gaagauggca t                                                 21


<210> 7065
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 7065
caacaucaag gaagauggca                                                   20


<210> 7066
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 7066
caacaucaag gaagauggc                                                    19


<210> 7067
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 7067
caacaucaag gaagaugg                                                     18


<210> 7068
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 7068
caacaucaag gaagaug                                                      17


<210> 7069
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 7069
caacaucaag gaagat                                                       16


<210> 7070
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 7070
caacaucaag gaaga                                                        15


<210> 7071
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 7071
caacaucaag gaag                                                         14


<210> 7072
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 7072
aacaucaagg aagauggcau uucuag                                            26


<210> 7073
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 7073
aacaucaagg aagauggcau uucua                                             25


<210> 7074
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 7074
aacaucaagg aagauggcau uuct                                              24


<210> 7075
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 7075
aacaucaagg aagauggcau uuc                                               23


<210> 7076
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 7076
aacaucaagg aagauggcau ut                                                22


<210> 7077
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 7077
aacaucaagg aagauggcau t                                                 21


<210> 7078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 7078
aacaucaagg aagauggcat                                                   20


<210> 7079
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 7079
aacaucaagg aagauggca                                                    19


<210> 7080
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 7080
aacaucaagg aagauggc                                                     18


<210> 7081
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 7081
aacaucaagg aagaugg                                                      17


<210> 7082
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 7082
aacaucaagg aagaug                                                       16


<210> 7083
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 7083
aacaucaagg aagat                                                        15


<210> 7084
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 7084
aacaucaagg aaga                                                         14


<210> 7085
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 7085
aacaucaagg aag                                                          13


<210> 7086
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 7086
acaucaagga agauggcauu ucuag                                             25


<210> 7087
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 7087
acaucaagga agauggcauu ucua                                              24


<210> 7088
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 7088
acaucaagga agauggcauu uct                                               23


<210> 7089
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 7089
acaucaagga agauggcauu uc                                                22


<210> 7090
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 7090
acaucaagga agauggcauu t                                                 21


<210> 7091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 7091
acaucaagga agauggcaut                                                   20


<210> 7092
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 7092
acaucaagga agauggcat                                                    19


<210> 7093
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 7093
acaucaagga agauggca                                                     18


<210> 7094
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 7094
acaucaagga agauggc                                                      17


<210> 7095
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 7095
acaucaagga agaugg                                                       16


<210> 7096
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 7096
acaucaagga agaug                                                        15


<210> 7097
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 7097
acaucaagga agat                                                         14


<210> 7098
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 7098
acaucaagga aga                                                          13


<210> 7099
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 7099
acaucaagga ag                                                           12


<210> 7100
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 7100
caucaaggaa gauggcauuu cuag                                              24


<210> 7101
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 7101
caucaaggaa gauggcauuu cua                                               23


<210> 7102
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 7102
caucaaggaa gauggcauuu ct                                                22


<210> 7103
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 7103
caucaaggaa gauggcauuu c                                                 21


<210> 7104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 7104
caucaaggaa gauggcauut                                                   20


<210> 7105
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 7105
caucaaggaa gauggcaut                                                    19


<210> 7106
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 7106
caucaaggaa gauggcat                                                     18


<210> 7107
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 7107
caucaaggaa gauggca                                                      17


<210> 7108
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 7108
caucaaggaa gauggc                                                       16


<210> 7109
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 7109
caucaaggaa gaugg                                                        15


<210> 7110
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 7110
caucaaggaa gaug                                                         14


<210> 7111
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 7111
caucaaggaa gat                                                          13


<210> 7112
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 7112
caucaaggaa ga                                                           12


<210> 7113
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 7113
caucaaggaa g                                                            11


<210> 7114
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 7114
aucaaggaag auggcauuuc uag                                               23


<210> 7115
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 7115
aucaaggaag auggcauuuc ua                                                22


<210> 7116
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 7116
aucaaggaag auggcauuuc t                                                 21


<210> 7117
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 7117
aucaaggaag auggcauuuc                                                   20


<210> 7118
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 7118
aucaaggaag auggcauut                                                    19


<210> 7119
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 7119
aucaaggaag auggcaut                                                     18


<210> 7120
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 7120
aucaaggaag auggcat                                                      17


<210> 7121
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 7121
aucaaggaag auggca                                                       16


<210> 7122
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 7122
aucaaggaag auggc                                                        15


<210> 7123
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 7123
aucaaggaag augg                                                         14


<210> 7124
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 7124
aucaaggaag aug                                                          13


<210> 7125
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 7125
aucaaggaag at                                                           12


<210> 7126
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 7126
aucaaggaag a                                                            11


<210> 7127
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 7127
aucaaggaag                                                              10


<210> 7128
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 7128
ccagagcagg uaccuccaac auc                                               23


<210> 7129
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 7129
ccagagcagg uaccucca                                                     18


<210> 7130
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 7130
ccucugugau uuuauaacuu gat                                               23


<210> 7131
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 7131
tcacccacca ucaccct                                                      17


<210> 7132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 7132
tgauauccuc aaggucaccc                                                   20


<210> 7133
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 7133
cugcuugaug aucaucucgu ug                                                22


<210> 7134
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 7134
cugcuugaug aucaucuc                                                     18


<210> 7135
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 7135
guuuccuuag uaaccacag                                                    19


<210> 7136
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 7136
guuuccuuag uaaccac                                                      17


<210> 7137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7137
tcaaggaaga uggcauuuct                                                   20


<210> 7138
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7138
tcaaggaaga uggcauuucu ag                                                22


<210> 7139
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7139
gguaaguucu guccaagc                                                     18


<210> 7140
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7140
guaaguucug uccaagcc                                                     18


<210> 7141
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7141
agucgguaag uucugucc                                                     18


<210> 7142
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7142
cuguccaagc ccgguuga                                                     18


<210> 7143
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7143
taaguucugu ccaag                                                        15


<210> 7144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7144
tucuguccaa gcccgguuga                                                   20


<210> 7145
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7145
tucuguccaa gcccgguug                                                    19


<210> 7146
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7146
tucuguccaa gcccggut                                                     18


<210> 7147
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7147
tucuguccaa gcccggt                                                      17


<210> 7148
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7148
tucuguccaa gcccgg                                                       16


<210> 7149
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7149
tucuguccaa gcccg                                                        15


<210> 7150
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7150
tucuguccaa gccc                                                         14


<210> 7151
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7151
tucuguccaa gcc                                                          13


<210> 7152
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7152
tucuguccaa gc                                                           12


<210> 7153
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7153
tucuguccaa g                                                            11


<210> 7154
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7154
tucuguccaa                                                              10


<210> 7155
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7155
tucugucca                                                                9


<210> 7156
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7156
tucugucc                                                                 8


<210> 7157
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7157
tcuguccaag cccgguuga                                                    19


<210> 7158
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7158
tcuguccaag cccgguug                                                     18


<210> 7159
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7159
tcuguccaag cccggut                                                      17


<210> 7160
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7160
tcuguccaag cccggt                                                       16


<210> 7161
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7161
tcuguccaag cccgg                                                        15


<210> 7162
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7162
tcuguccaag cccg                                                         14


<210> 7163
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7163
tcuguccaag ccc                                                          13


<210> 7164
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7164
tcuguccaag cc                                                           12


<210> 7165
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7165
tcuguccaag c                                                            11


<210> 7166
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7166
tcuguccaag                                                              10


<210> 7167
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7167
tcuguccaa                                                                9


<210> 7168
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7168
tcugucca                                                                 8


<210> 7169
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7169
cuguccaagc ccgguug                                                      17


<210> 7170
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7170
cuguccaagc ccggut                                                       16


<210> 7171
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7171
cuguccaagc ccggt                                                        15


<210> 7172
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7172
cuguccaagc ccgg                                                         14


<210> 7173
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7173
cuguccaagc ccg                                                          13


<210> 7174
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7174
cuguccaagc cc                                                           12


<210> 7175
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7175
cuguccaagc c                                                            11


<210> 7176
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7176
cuguccaagc                                                              10


<210> 7177
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7177
cuguccaag                                                                9


<210> 7178
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7178
cuguccaa                                                                 8


<210> 7179
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7179
guucugucca agcccgguug                                                   20


<210> 7180
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7180
guucugucca agcccggut                                                    19


<210> 7181
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7181
guucugucca agcccggt                                                     18


<210> 7182
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7182
guucugucca agcccgg                                                      17


<210> 7183
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7183
guucugucca agcccg                                                       16


<210> 7184
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7184
guucugucca agccc                                                        15


<210> 7185
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7185
guucugucca agcc                                                         14


<210> 7186
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7186
guucugucca agc                                                          13


<210> 7187
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7187
guucugucca ag                                                           12


<210> 7188
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7188
guucugucca a                                                            11


<210> 7189
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7189
guucugucca                                                              10


<210> 7190
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7190
guucugucc                                                                9


<210> 7191
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7191
guucuguc                                                                 8


<210> 7192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7192
aguucugucc aagcccggut                                                   20


<210> 7193
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7193
aguucugucc aagcccggt                                                    19


<210> 7194
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7194
aguucugucc aagcccgg                                                     18


<210> 7195
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7195
aguucugucc aagcccg                                                      17


<210> 7196
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7196
aguucugucc aagccc                                                       16


<210> 7197
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7197
aguucugucc aagcc                                                        15


<210> 7198
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7198
aguucugucc aagc                                                         14


<210> 7199
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7199
aguucugucc aag                                                          13


<210> 7200
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7200
aguucugucc aa                                                           12


<210> 7201
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7201
aguucugucc a                                                            11


<210> 7202
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7202
aguucugucc                                                              10


<210> 7203
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7203
aguucuguc                                                                9


<210> 7204
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7204
aguucugt                                                                 8


<210> 7205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7205
aaguucuguc caagcccggt                                                   20


<210> 7206
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7206
aaguucuguc caagcccgg                                                    19


<210> 7207
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7207
aaguucuguc caagcccg                                                     18


<210> 7208
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7208
aaguucuguc caagccc                                                      17


<210> 7209
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7209
aaguucuguc caagcc                                                       16


<210> 7210
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7210
aaguucuguc caagc                                                        15


<210> 7211
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7211
aaguucuguc caag                                                         14


<210> 7212
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7212
aaguucuguc caa                                                          13


<210> 7213
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7213
aaguucuguc ca                                                           12


<210> 7214
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7214
aaguucuguc c                                                            11


<210> 7215
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7215
aaguucuguc                                                              10


<210> 7216
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7216
aaguucugt                                                                9


<210> 7217
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7217
aaguucug                                                                 8


<210> 7218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7218
taaguucugu ccaagcccgg                                                   20


<210> 7219
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7219
taaguucugu ccaagcccg                                                    19


<210> 7220
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7220
taaguucugu ccaagccc                                                     18


<210> 7221
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7221
taaguucugu ccaagcc                                                      17


<210> 7222
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7222
taaguucugu ccaagc                                                       16


<210> 7223
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7223
taaguucugu ccaa                                                         14


<210> 7224
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7224
taaguucugu cca                                                          13


<210> 7225
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7225
taaguucugu cc                                                           12


<210> 7226
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7226
taaguucugu c                                                            11


<210> 7227
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7227
taaguucugt                                                              10


<210> 7228
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7228
taaguucug                                                                9


<210> 7229
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7229
taaguuct                                                                 8


<210> 7230
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7230
guaaguucug uccaagcccg                                                   20


<210> 7231
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7231
guaaguucug uccaagccc                                                    19


<210> 7232
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7232
guaaguucug uccaagc                                                      17


<210> 7233
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7233
guaaguucug uccaag                                                       16


<210> 7234
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7234
guaaguucug uccaa                                                        15


<210> 7235
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7235
guaaguucug ucca                                                         14


<210> 7236
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7236
guaaguucug ucc                                                          13


<210> 7237
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7237
guaaguucug uc                                                           12


<210> 7238
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7238
guaaguucug t                                                            11


<210> 7239
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7239
guaaguucug                                                              10


<210> 7240
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7240
guaaguuct                                                                9


<210> 7241
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7241
guaaguuc                                                                 8


<210> 7242
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7242
gguaaguucu guccaagccc                                                   20


<210> 7243
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7243
gguaaguucu guccaagcc                                                    19


<210> 7244
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7244
gguaaguucu guccaag                                                      17


<210> 7245
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7245
gguaaguucu guccaa                                                       16


<210> 7246
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7246
gguaaguucu gucca                                                        15


<210> 7247
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7247
gguaaguucu gucc                                                         14


<210> 7248
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7248
gguaaguucu guc                                                          13


<210> 7249
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7249
gguaaguucu gt                                                           12


<210> 7250
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7250
gguaaguucu g                                                            11


<210> 7251
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7251
gguaaguuct                                                              10


<210> 7252
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7252
gguaaguuc                                                                9


<210> 7253
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7253
gguaagut                                                                 8


<210> 7254
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7254
cgguaaguuc uguccaagcc                                                   20


<210> 7255
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7255
cgguaaguuc uguccaagc                                                    19


<210> 7256
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7256
cgguaaguuc uguccaag                                                     18


<210> 7257
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7257
cgguaaguuc uguccaa                                                      17


<210> 7258
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7258
cgguaaguuc ugucca                                                       16


<210> 7259
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7259
cgguaaguuc ugucc                                                        15


<210> 7260
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7260
cgguaaguuc uguc                                                         14


<210> 7261
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7261
cgguaaguuc ugt                                                          13


<210> 7262
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7262
cgguaaguuc ug                                                           12


<210> 7263
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7263
cgguaaguuc t                                                            11


<210> 7264
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7264
cgguaaguuc                                                              10


<210> 7265
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7265
cgguaagut                                                                9


<210> 7266
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7266
cgguaagt                                                                 8


<210> 7267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7267
tcgguaaguu cuguccaagc                                                   20


<210> 7268
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7268
tcgguaaguu cuguccaag                                                    19


<210> 7269
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7269
tcgguaaguu cuguccaa                                                     18


<210> 7270
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7270
tcgguaaguu cugucca                                                      17


<210> 7271
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7271
tcgguaaguu cugucc                                                       16


<210> 7272
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7272
tcgguaaguu cuguc                                                        15


<210> 7273
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7273
tcgguaaguu cugt                                                         14


<210> 7274
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7274
tcgguaaguu cug                                                          13


<210> 7275
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7275
tcgguaaguu ct                                                           12


<210> 7276
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7276
tcgguaaguu c                                                            11


<210> 7277
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7277
tcgguaagut                                                              10


<210> 7278
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7278
tcgguaagt                                                                9


<210> 7279
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7279
gucgguaagu ucuguccaag                                                   20


<210> 7280
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7280
gucgguaagu ucuguccaa                                                    19


<210> 7281
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7281
gucgguaagu ucugucca                                                     18


<210> 7282
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7282
gucgguaagu ucugucc                                                      17


<210> 7283
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7283
gucgguaagu ucuguc                                                       16


<210> 7284
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7284
gucgguaagu ucugt                                                        15


<210> 7285
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7285
gucgguaagu ucug                                                         14


<210> 7286
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7286
gucgguaagu uct                                                          13


<210> 7287
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7287
gucgguaagu uc                                                           12


<210> 7288
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7288
gucgguaagu t                                                            11


<210> 7289
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7289
gucgguaagt                                                              10


<210> 7290
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7290
agucgguaag uucuguccaa                                                   20


<210> 7291
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7291
agucgguaag uucugucca                                                    19


<210> 7292
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7292
agucgguaag uucuguc                                                      17


<210> 7293
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7293
agucgguaag uucugt                                                       16


<210> 7294
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7294
agucgguaag uucug                                                        15


<210> 7295
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7295
agucgguaag uuct                                                         14


<210> 7296
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7296
agucgguaag uuc                                                          13


<210> 7297
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7297
agucgguaag ut                                                           12


<210> 7298
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7298
agucgguaag t                                                            11


<210> 7299
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7299
cagucgguaa guucugucca                                                   20


<210> 7300
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7300
cagucgguaa guucugucc                                                    19


<210> 7301
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7301
cagucgguaa guucuguc                                                     18


<210> 7302
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7302
cagucgguaa guucugt                                                      17


<210> 7303
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7303
cagucgguaa guucug                                                       16


<210> 7304
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7304
cagucgguaa guuct                                                        15


<210> 7305
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7305
cagucgguaa guuc                                                         14


<210> 7306
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7306
cagucgguaa gut                                                          13


<210> 7307
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7307
cagucgguaa gt                                                           12


<210> 7308
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7308
ccagucggua aguucugucc                                                   20


<210> 7309
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7309
ccagucggua aguucuguc                                                    19


<210> 7310
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7310
ccagucggua aguucugt                                                     18


<210> 7311
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7311
ccagucggua aguucug                                                      17


<210> 7312
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7312
ccagucggua aguuct                                                       16


<210> 7313
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7313
ccagucggua aguuc                                                        15


<210> 7314
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7314
ccagucggua agut                                                         14


<210> 7315
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7315
ccagucggua agt                                                          13


<210> 7316
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7316
gccagucggu aaguucuguc                                                   20


<210> 7317
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7317
gccagucggu aaguucugt                                                    19


<210> 7318
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7318
gccagucggu aaguucug                                                     18


<210> 7319
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7319
gccagucggu aaguuct                                                      17


<210> 7320
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7320
gccagucggu aaguuc                                                       16


<210> 7321
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7321
gccagucggu aagut                                                        15


<210> 7322
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7322
gccagucggu aagt                                                         14


<210> 7323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7323
tcaaggaaga uggcauuuct                                                   20


<210> 7324
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7324
tcaaggaaga uggcauuucu ag                                                22


<210> 7325
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7325
tcaaggaaga uggcat                                                       16


<210> 7326
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7326
gaagauggca uuuct                                                        15


<210> 7327
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7327
tcaaggaaga uggcauuucu a                                                 21


<210> 7328
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7328
tcaaggaaga uggcauuuc                                                    19


<210> 7329
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7329
tcaaggaaga uggcauut                                                     18


<210> 7330
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7330
tcaaggaaga uggcaut                                                      17


<210> 7331
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7331
tcaaggaaga uggca                                                        15


<210> 7332
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7332
tcaaggaaga uggc                                                         14


<210> 7333
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7333
tcaaggaaga ugg                                                          13


<210> 7334
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7334
tcaaggaaga ug                                                           12


<210> 7335
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7335
tcaaggaaga t                                                            11


<210> 7336
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7336
tcaaggaaga                                                              10


<210> 7337
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7337
tcaaggaag                                                                9


<210> 7338
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7338
caaggaagau ggcauuucua g                                                 21


<210> 7339
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7339
caaggaagau ggcauuucua                                                   20


<210> 7340
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7340
caaggaagau ggcauuuct                                                    19


<210> 7341
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7341
caaggaagau ggcauuuc                                                     18


<210> 7342
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7342
caaggaagau ggcauut                                                      17


<210> 7343
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7343
caaggaagau ggcaut                                                       16


<210> 7344
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7344
caaggaagau ggcat                                                        15


<210> 7345
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7345
caaggaagau ggca                                                         14


<210> 7346
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7346
caaggaagau ggc                                                          13


<210> 7347
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7347
caaggaagau gg                                                           12


<210> 7348
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7348
caaggaagau g                                                            11


<210> 7349
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7349
caaggaagat                                                              10


<210> 7350
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7350
caaggaaga                                                                9


<210> 7351
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7351
caaggaag                                                                 8


<210> 7352
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7352
aaggaagaug gcauuucuag                                                   20


<210> 7353
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7353
aaggaagaug gcauuucua                                                    19


<210> 7354
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7354
aaggaagaug gcauuuct                                                     18


<210> 7355
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7355
aaggaagaug gcauuuc                                                      17


<210> 7356
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7356
aaggaagaug gcauut                                                       16


<210> 7357
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7357
aaggaagaug gcaut                                                        15


<210> 7358
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7358
aaggaagaug gcat                                                         14


<210> 7359
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7359
aaggaagaug gca                                                          13


<210> 7360
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7360
aaggaagaug gc                                                           12


<210> 7361
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7361
aaggaagaug g                                                            11


<210> 7362
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7362
aaggaagaug                                                              10


<210> 7363
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7363
aaggaagat                                                                9


<210> 7364
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7364
aaggaaga                                                                 8


<210> 7365
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7365
aggaagaugg cauuucuag                                                    19


<210> 7366
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7366
aggaagaugg cauuucua                                                     18


<210> 7367
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7367
aggaagaugg cauuuct                                                      17


<210> 7368
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7368
aggaagaugg cauuuc                                                       16


<210> 7369
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7369
aggaagaugg cauut                                                        15


<210> 7370
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7370
aggaagaugg caut                                                         14


<210> 7371
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7371
aggaagaugg cat                                                          13


<210> 7372
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7372
aggaagaugg ca                                                           12


<210> 7373
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7373
aggaagaugg                                                              10


<210> 7374
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7374
aggaagaug                                                                9


<210> 7375
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7375
aggaagat                                                                 8


<210> 7376
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7376
ggaagauggc auuucuag                                                     18


<210> 7377
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7377
ggaagauggc auuucua                                                      17


<210> 7378
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7378
ggaagauggc auuuct                                                       16


<210> 7379
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7379
ggaagauggc auuuc                                                        15


<210> 7380
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7380
ggaagauggc auut                                                         14


<210> 7381
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7381
ggaagauggc aut                                                          13


<210> 7382
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7382
ggaagauggc at                                                           12


<210> 7383
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7383
ggaagauggc a                                                            11


<210> 7384
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7384
ggaagauggc                                                              10


<210> 7385
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7385
ggaagaug                                                                 8


<210> 7386
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7386
gaagauggca uuucuag                                                      17


<210> 7387
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7387
gaagauggca uuucua                                                       16


<210> 7388
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7388
gaagauggca uuuc                                                         14


<210> 7389
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7389
gaagauggca uut                                                          13


<210> 7390
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7390
gaagauggca ut                                                           12


<210> 7391
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7391
gaagauggca t                                                            11


<210> 7392
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7392
gaagauggca                                                              10


<210> 7393
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7393
gaagauggc                                                                9


<210> 7394
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7394
gaagaugg                                                                 8


<210> 7395
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7395
aagauggcau uucuag                                                       16


<210> 7396
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7396
aagauggcau uucua                                                        15


<210> 7397
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7397
aagauggcau uuct                                                         14


<210> 7398
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7398
aagauggcau uuc                                                          13


<210> 7399
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7399
aagauggcau ut                                                           12


<210> 7400
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7400
aagauggcau t                                                            11


<210> 7401
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7401
aagauggcat                                                              10


<210> 7402
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7402
aagauggca                                                                9


<210> 7403
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7403
aagauggc                                                                 8


<210> 7404
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7404
agauggcauu ucuag                                                        15


<210> 7405
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7405
agauggcauu ucua                                                         14


<210> 7406
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7406
agauggcauu uct                                                          13


<210> 7407
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7407
agauggcauu uc                                                           12


<210> 7408
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7408
agauggcauu t                                                            11


<210> 7409
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7409
agauggcaut                                                              10


<210> 7410
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7410
agauggcat                                                                9


<210> 7411
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7411
agauggca                                                                 8


<210> 7412
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7412
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 7413
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7413
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 7414
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7414
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 7415
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7415
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 7416
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7416
cuccaacauc aaggaagaug gcauut                                            26


<210> 7417
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7417
cuccaacauc aaggaagaug gcaut                                             25


<210> 7418
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7418
cuccaacauc aaggaagaug gcat                                              24


<210> 7419
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7419
cuccaacauc aaggaagaug gca                                               23


<210> 7420
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7420
cuccaacauc aaggaagaug gc                                                22


<210> 7421
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7421
cuccaacauc aaggaagaug g                                                 21


<210> 7422
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7422
cuccaacauc aaggaagaug                                                   20


<210> 7423
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7423
cuccaacauc aaggaagat                                                    19


<210> 7424
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7424
cuccaacauc aaggaaga                                                     18


<210> 7425
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7425
cuccaacauc aaggaag                                                      17


<210> 7426
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7426
tccaacauca aggaagaugg cauuucuag                                         29


<210> 7427
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7427
tccaacauca aggaagaugg cauuucua                                          28


<210> 7428
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7428
tccaacauca aggaagaugg cauuuct                                           27


<210> 7429
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7429
tccaacauca aggaagaugg cauuuc                                            26


<210> 7430
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7430
tccaacauca aggaagaugg cauut                                             25


<210> 7431
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7431
tccaacauca aggaagaugg caut                                              24


<210> 7432
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7432
tccaacauca aggaagaugg cat                                               23


<210> 7433
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7433
tccaacauca aggaagaugg ca                                                22


<210> 7434
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7434
tccaacauca aggaagaugg c                                                 21


<210> 7435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7435
tccaacauca aggaagaugg                                                   20


<210> 7436
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7436
tccaacauca aggaagaug                                                    19


<210> 7437
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7437
tccaacauca aggaagat                                                     18


<210> 7438
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7438
tccaacauca aggaaga                                                      17


<210> 7439
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7439
tccaacauca aggaag                                                       16


<210> 7440
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7440
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 7441
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7441
ccaacaucaa ggaagauggc auuucua                                           27


<210> 7442
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7442
ccaacaucaa ggaagauggc auuuct                                            26


<210> 7443
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7443
ccaacaucaa ggaagauggc auuuc                                             25


<210> 7444
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7444
ccaacaucaa ggaagauggc auut                                              24


<210> 7445
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7445
ccaacaucaa ggaagauggc aut                                               23


<210> 7446
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7446
ccaacaucaa ggaagauggc at                                                22


<210> 7447
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7447
ccaacaucaa ggaagauggc a                                                 21


<210> 7448
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7448
ccaacaucaa ggaagauggc                                                   20


<210> 7449
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7449
ccaacaucaa ggaagaugg                                                    19


<210> 7450
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7450
ccaacaucaa ggaagaug                                                     18


<210> 7451
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7451
ccaacaucaa ggaagat                                                      17


<210> 7452
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7452
ccaacaucaa ggaaga                                                       16


<210> 7453
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7453
ccaacaucaa ggaag                                                        15


<210> 7454
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7454
caacaucaag gaagauggca uuucuag                                           27


<210> 7455
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7455
caacaucaag gaagauggca uuucua                                            26


<210> 7456
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7456
caacaucaag gaagauggca uuuct                                             25


<210> 7457
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7457
caacaucaag gaagauggca uuuc                                              24


<210> 7458
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7458
caacaucaag gaagauggca uut                                               23


<210> 7459
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7459
caacaucaag gaagauggca ut                                                22


<210> 7460
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7460
caacaucaag gaagauggca t                                                 21


<210> 7461
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7461
caacaucaag gaagauggca                                                   20


<210> 7462
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7462
caacaucaag gaagauggc                                                    19


<210> 7463
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7463
caacaucaag gaagaugg                                                     18


<210> 7464
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7464
caacaucaag gaagaug                                                      17


<210> 7465
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7465
caacaucaag gaagat                                                       16


<210> 7466
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7466
caacaucaag gaaga                                                        15


<210> 7467
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7467
caacaucaag gaag                                                         14


<210> 7468
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7468
aacaucaagg aagauggcau uucuag                                            26


<210> 7469
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7469
aacaucaagg aagauggcau uucua                                             25


<210> 7470
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7470
aacaucaagg aagauggcau uuct                                              24


<210> 7471
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7471
aacaucaagg aagauggcau uuc                                               23


<210> 7472
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7472
aacaucaagg aagauggcau ut                                                22


<210> 7473
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7473
aacaucaagg aagauggcau t                                                 21


<210> 7474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7474
aacaucaagg aagauggcat                                                   20


<210> 7475
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7475
aacaucaagg aagauggca                                                    19


<210> 7476
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7476
aacaucaagg aagauggc                                                     18


<210> 7477
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7477
aacaucaagg aagaugg                                                      17


<210> 7478
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7478
aacaucaagg aagaug                                                       16


<210> 7479
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7479
aacaucaagg aagat                                                        15


<210> 7480
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7480
aacaucaagg aaga                                                         14


<210> 7481
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7481
aacaucaagg aag                                                          13


<210> 7482
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7482
acaucaagga agauggcauu ucuag                                             25


<210> 7483
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7483
acaucaagga agauggcauu ucua                                              24


<210> 7484
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7484
acaucaagga agauggcauu uct                                               23


<210> 7485
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7485
acaucaagga agauggcauu uc                                                22


<210> 7486
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7486
acaucaagga agauggcauu t                                                 21


<210> 7487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7487
acaucaagga agauggcaut                                                   20


<210> 7488
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7488
acaucaagga agauggcat                                                    19


<210> 7489
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7489
acaucaagga agauggca                                                     18


<210> 7490
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7490
acaucaagga agauggc                                                      17


<210> 7491
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7491
acaucaagga agaugg                                                       16


<210> 7492
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7492
acaucaagga agaug                                                        15


<210> 7493
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7493
acaucaagga agat                                                         14


<210> 7494
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7494
acaucaagga aga                                                          13


<210> 7495
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7495
acaucaagga ag                                                           12


<210> 7496
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7496
caucaaggaa gauggcauuu cuag                                              24


<210> 7497
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7497
caucaaggaa gauggcauuu cua                                               23


<210> 7498
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7498
caucaaggaa gauggcauuu ct                                                22


<210> 7499
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7499
caucaaggaa gauggcauuu c                                                 21


<210> 7500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7500
caucaaggaa gauggcauut                                                   20


<210> 7501
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7501
caucaaggaa gauggcaut                                                    19


<210> 7502
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7502
caucaaggaa gauggcat                                                     18


<210> 7503
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7503
caucaaggaa gauggca                                                      17


<210> 7504
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7504
caucaaggaa gauggc                                                       16


<210> 7505
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7505
caucaaggaa gaugg                                                        15


<210> 7506
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7506
caucaaggaa gaug                                                         14


<210> 7507
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7507
caucaaggaa gat                                                          13


<210> 7508
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7508
caucaaggaa ga                                                           12


<210> 7509
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7509
caucaaggaa g                                                            11


<210> 7510
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7510
aucaaggaag auggcauuuc uag                                               23


<210> 7511
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7511
aucaaggaag auggcauuuc ua                                                22


<210> 7512
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7512
aucaaggaag auggcauuuc t                                                 21


<210> 7513
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7513
aucaaggaag auggcauuuc                                                   20


<210> 7514
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7514
aucaaggaag auggcauut                                                    19


<210> 7515
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7515
aucaaggaag auggcaut                                                     18


<210> 7516
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7516
aucaaggaag auggcat                                                      17


<210> 7517
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7517
aucaaggaag auggca                                                       16


<210> 7518
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7518
aucaaggaag auggc                                                        15


<210> 7519
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7519
aucaaggaag augg                                                         14


<210> 7520
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7520
aucaaggaag aug                                                          13


<210> 7521
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7521
aucaaggaag at                                                           12


<210> 7522
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7522
aucaaggaag a                                                            11


<210> 7523
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7523
aucaaggaag                                                              10


<210> 7524
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7524
ccagagcagg uaccuccaac auc                                               23


<210> 7525
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7525
ccagagcagg uaccucca                                                     18


<210> 7526
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7526
ccucugugau uuuauaacuu gat                                               23


<210> 7527
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7527
tcacccacca ucaccct                                                      17


<210> 7528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7528
tgauauccuc aaggucaccc                                                   20


<210> 7529
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7529
cugcuugaug aucaucucgu ug                                                22


<210> 7530
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7530
cugcuugaug aucaucuc                                                     18


<210> 7531
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7531
guuuccuuag uaaccacag                                                    19


<210> 7532
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7532
guuuccuuag uaaccac                                                      17


<210> 7533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7533
tcaaggaaga uggcauuuct                                                   20


<210> 7534
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7534
tcaaggaaga uggcauuucu ag                                                22


<210> 7535
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7535
gguaaguucu guccaagc                                                     18


<210> 7536
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7536
guaaguucug uccaagcc                                                     18


<210> 7537
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7537
agucgguaag uucugucc                                                     18


<210> 7538
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7538
cuguccaagc ccgguuga                                                     18


<210> 7539
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7539
taaguucugu ccaag                                                        15


<210> 7540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7540
tucuguccaa gcccgguuga                                                   20


<210> 7541
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7541
tucuguccaa gcccgguug                                                    19


<210> 7542
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7542
tucuguccaa gcccggut                                                     18


<210> 7543
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7543
tucuguccaa gcccggt                                                      17


<210> 7544
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7544
tucuguccaa gcccgg                                                       16


<210> 7545
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7545
tucuguccaa gcccg                                                        15


<210> 7546
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7546
tucuguccaa gccc                                                         14


<210> 7547
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7547
tucuguccaa gcc                                                          13


<210> 7548
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7548
tucuguccaa gc                                                           12


<210> 7549
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7549
tucuguccaa g                                                            11


<210> 7550
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7550
tucuguccaa                                                              10


<210> 7551
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7551
tucugucca                                                                9


<210> 7552
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7552
tucugucc                                                                 8


<210> 7553
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7553
tcuguccaag cccgguuga                                                    19


<210> 7554
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7554
tcuguccaag cccgguug                                                     18


<210> 7555
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7555
tcuguccaag cccggut                                                      17


<210> 7556
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7556
tcuguccaag cccggt                                                       16


<210> 7557
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7557
tcuguccaag cccgg                                                        15


<210> 7558
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7558
tcuguccaag cccg                                                         14


<210> 7559
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7559
tcuguccaag ccc                                                          13


<210> 7560
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7560
tcuguccaag cc                                                           12


<210> 7561
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7561
tcuguccaag c                                                            11


<210> 7562
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7562
tcuguccaag                                                              10


<210> 7563
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7563
tcuguccaa                                                                9


<210> 7564
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7564
tcugucca                                                                 8


<210> 7565
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7565
cuguccaagc ccgguug                                                      17


<210> 7566
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7566
cuguccaagc ccggut                                                       16


<210> 7567
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7567
cuguccaagc ccggt                                                        15


<210> 7568
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7568
cuguccaagc ccgg                                                         14


<210> 7569
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7569
cuguccaagc ccg                                                          13


<210> 7570
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7570
cuguccaagc cc                                                           12


<210> 7571
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7571
cuguccaagc c                                                            11


<210> 7572
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7572
cuguccaagc                                                              10


<210> 7573
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7573
cuguccaag                                                                9


<210> 7574
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7574
cuguccaa                                                                 8


<210> 7575
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7575
guucugucca agcccgguug                                                   20


<210> 7576
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7576
guucugucca agcccggut                                                    19


<210> 7577
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7577
guucugucca agcccggt                                                     18


<210> 7578
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7578
guucugucca agcccgg                                                      17


<210> 7579
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7579
guucugucca agcccg                                                       16


<210> 7580
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7580
guucugucca agccc                                                        15


<210> 7581
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7581
guucugucca agcc                                                         14


<210> 7582
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7582
guucugucca agc                                                          13


<210> 7583
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7583
guucugucca ag                                                           12


<210> 7584
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7584
guucugucca a                                                            11


<210> 7585
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7585
guucugucca                                                              10


<210> 7586
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7586
guucugucc                                                                9


<210> 7587
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7587
guucuguc                                                                 8


<210> 7588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7588
aguucugucc aagcccggut                                                   20


<210> 7589
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7589
aguucugucc aagcccggt                                                    19


<210> 7590
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7590
aguucugucc aagcccgg                                                     18


<210> 7591
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7591
aguucugucc aagcccg                                                      17


<210> 7592
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7592
aguucugucc aagccc                                                       16


<210> 7593
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7593
aguucugucc aagcc                                                        15


<210> 7594
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7594
aguucugucc aagc                                                         14


<210> 7595
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7595
aguucugucc aag                                                          13


<210> 7596
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7596
aguucugucc aa                                                           12


<210> 7597
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7597
aguucugucc a                                                            11


<210> 7598
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7598
aguucugucc                                                              10


<210> 7599
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7599
aguucuguc                                                                9


<210> 7600
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7600
aguucugt                                                                 8


<210> 7601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7601
aaguucuguc caagcccggt                                                   20


<210> 7602
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7602
aaguucuguc caagcccgg                                                    19


<210> 7603
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7603
aaguucuguc caagcccg                                                     18


<210> 7604
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7604
aaguucuguc caagccc                                                      17


<210> 7605
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7605
aaguucuguc caagcc                                                       16


<210> 7606
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7606
aaguucuguc caagc                                                        15


<210> 7607
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7607
aaguucuguc caag                                                         14


<210> 7608
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7608
aaguucuguc caa                                                          13


<210> 7609
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7609
aaguucuguc ca                                                           12


<210> 7610
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7610
aaguucuguc c                                                            11


<210> 7611
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7611
aaguucuguc                                                              10


<210> 7612
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7612
aaguucugt                                                                9


<210> 7613
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7613
aaguucug                                                                 8


<210> 7614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7614
taaguucugu ccaagcccgg                                                   20


<210> 7615
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7615
taaguucugu ccaagcccg                                                    19


<210> 7616
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7616
taaguucugu ccaagccc                                                     18


<210> 7617
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7617
taaguucugu ccaagcc                                                      17


<210> 7618
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7618
taaguucugu ccaagc                                                       16


<210> 7619
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7619
taaguucugu ccaa                                                         14


<210> 7620
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7620
taaguucugu cca                                                          13


<210> 7621
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7621
taaguucugu cc                                                           12


<210> 7622
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7622
taaguucugu c                                                            11


<210> 7623
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7623
taaguucugt                                                              10


<210> 7624
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7624
taaguucug                                                                9


<210> 7625
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7625
taaguuct                                                                 8


<210> 7626
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7626
guaaguucug uccaagcccg                                                   20


<210> 7627
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7627
guaaguucug uccaagccc                                                    19


<210> 7628
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7628
guaaguucug uccaagc                                                      17


<210> 7629
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7629
guaaguucug uccaag                                                       16


<210> 7630
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7630
guaaguucug uccaa                                                        15


<210> 7631
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7631
guaaguucug ucca                                                         14


<210> 7632
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7632
guaaguucug ucc                                                          13


<210> 7633
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7633
guaaguucug uc                                                           12


<210> 7634
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7634
guaaguucug t                                                            11


<210> 7635
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7635
guaaguucug                                                              10


<210> 7636
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7636
guaaguuct                                                                9


<210> 7637
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7637
guaaguuc                                                                 8


<210> 7638
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7638
gguaaguucu guccaagccc                                                   20


<210> 7639
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7639
gguaaguucu guccaagcc                                                    19


<210> 7640
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7640
gguaaguucu guccaag                                                      17


<210> 7641
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7641
gguaaguucu guccaa                                                       16


<210> 7642
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7642
gguaaguucu gucca                                                        15


<210> 7643
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7643
gguaaguucu gucc                                                         14


<210> 7644
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7644
gguaaguucu guc                                                          13


<210> 7645
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7645
gguaaguucu gt                                                           12


<210> 7646
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7646
gguaaguucu g                                                            11


<210> 7647
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7647
gguaaguuct                                                              10


<210> 7648
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7648
gguaaguuc                                                                9


<210> 7649
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7649
gguaagut                                                                 8


<210> 7650
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7650
cgguaaguuc uguccaagcc                                                   20


<210> 7651
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7651
cgguaaguuc uguccaagc                                                    19


<210> 7652
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7652
cgguaaguuc uguccaag                                                     18


<210> 7653
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7653
cgguaaguuc uguccaa                                                      17


<210> 7654
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7654
cgguaaguuc ugucca                                                       16


<210> 7655
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7655
cgguaaguuc ugucc                                                        15


<210> 7656
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7656
cgguaaguuc uguc                                                         14


<210> 7657
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7657
cgguaaguuc ugt                                                          13


<210> 7658
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7658
cgguaaguuc ug                                                           12


<210> 7659
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7659
cgguaaguuc t                                                            11


<210> 7660
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7660
cgguaaguuc                                                              10


<210> 7661
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7661
cgguaagut                                                                9


<210> 7662
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7662
cgguaagt                                                                 8


<210> 7663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7663
tcgguaaguu cuguccaagc                                                   20


<210> 7664
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7664
tcgguaaguu cuguccaag                                                    19


<210> 7665
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7665
tcgguaaguu cuguccaa                                                     18


<210> 7666
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7666
tcgguaaguu cugucca                                                      17


<210> 7667
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7667
tcgguaaguu cugucc                                                       16


<210> 7668
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7668
tcgguaaguu cuguc                                                        15


<210> 7669
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7669
tcgguaaguu cugt                                                         14


<210> 7670
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7670
tcgguaaguu cug                                                          13


<210> 7671
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7671
tcgguaaguu ct                                                           12


<210> 7672
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7672
tcgguaaguu c                                                            11


<210> 7673
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7673
tcgguaagut                                                              10


<210> 7674
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7674
tcgguaagt                                                                9


<210> 7675
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7675
gucgguaagu ucuguccaag                                                   20


<210> 7676
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7676
gucgguaagu ucuguccaa                                                    19


<210> 7677
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7677
gucgguaagu ucugucca                                                     18


<210> 7678
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7678
gucgguaagu ucugucc                                                      17


<210> 7679
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7679
gucgguaagu ucuguc                                                       16


<210> 7680
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7680
gucgguaagu ucugt                                                        15


<210> 7681
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7681
gucgguaagu ucug                                                         14


<210> 7682
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7682
gucgguaagu uct                                                          13


<210> 7683
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7683
gucgguaagu uc                                                           12


<210> 7684
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7684
gucgguaagu t                                                            11


<210> 7685
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7685
gucgguaagt                                                              10


<210> 7686
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7686
agucgguaag uucuguccaa                                                   20


<210> 7687
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7687
agucgguaag uucugucca                                                    19


<210> 7688
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7688
agucgguaag uucuguc                                                      17


<210> 7689
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7689
agucgguaag uucugt                                                       16


<210> 7690
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7690
agucgguaag uucug                                                        15


<210> 7691
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7691
agucgguaag uuct                                                         14


<210> 7692
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7692
agucgguaag uuc                                                          13


<210> 7693
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7693
agucgguaag ut                                                           12


<210> 7694
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7694
agucgguaag t                                                            11


<210> 7695
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7695
cagucgguaa guucugucca                                                   20


<210> 7696
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7696
cagucgguaa guucugucc                                                    19


<210> 7697
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7697
cagucgguaa guucuguc                                                     18


<210> 7698
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7698
cagucgguaa guucugt                                                      17


<210> 7699
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7699
cagucgguaa guucug                                                       16


<210> 7700
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7700
cagucgguaa guuct                                                        15


<210> 7701
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7701
cagucgguaa guuc                                                         14


<210> 7702
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7702
cagucgguaa gut                                                          13


<210> 7703
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7703
cagucgguaa gt                                                           12


<210> 7704
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7704
ccagucggua aguucugucc                                                   20


<210> 7705
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7705
ccagucggua aguucuguc                                                    19


<210> 7706
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7706
ccagucggua aguucugt                                                     18


<210> 7707
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7707
ccagucggua aguucug                                                      17


<210> 7708
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7708
ccagucggua aguuct                                                       16


<210> 7709
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7709
ccagucggua aguuc                                                        15


<210> 7710
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7710
ccagucggua agut                                                         14


<210> 7711
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7711
ccagucggua agt                                                          13


<210> 7712
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7712
gccagucggu aaguucuguc                                                   20


<210> 7713
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7713
gccagucggu aaguucugt                                                    19


<210> 7714
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7714
gccagucggu aaguucug                                                     18


<210> 7715
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7715
gccagucggu aaguuct                                                      17


<210> 7716
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7716
gccagucggu aaguuc                                                       16


<210> 7717
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7717
gccagucggu aagut                                                        15


<210> 7718
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7718
gccagucggu aagt                                                         14


<210> 7719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7719
tcaaggaaga uggcauuuct                                                   20


<210> 7720
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7720
tcaaggaaga uggcauuucu ag                                                22


<210> 7721
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7721
tcaaggaaga uggcat                                                       16


<210> 7722
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7722
gaagauggca uuuct                                                        15


<210> 7723
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7723
tcaaggaaga uggcauuucu a                                                 21


<210> 7724
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7724
tcaaggaaga uggcauuuc                                                    19


<210> 7725
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7725
tcaaggaaga uggcauut                                                     18


<210> 7726
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7726
tcaaggaaga uggcaut                                                      17


<210> 7727
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7727
tcaaggaaga uggca                                                        15


<210> 7728
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7728
tcaaggaaga uggc                                                         14


<210> 7729
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7729
tcaaggaaga ugg                                                          13


<210> 7730
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7730
tcaaggaaga ug                                                           12


<210> 7731
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7731
tcaaggaaga t                                                            11


<210> 7732
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7732
tcaaggaaga                                                              10


<210> 7733
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7733
tcaaggaag                                                                9


<210> 7734
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7734
caaggaagau ggcauuucua g                                                 21


<210> 7735
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7735
caaggaagau ggcauuucua                                                   20


<210> 7736
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7736
caaggaagau ggcauuuct                                                    19


<210> 7737
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7737
caaggaagau ggcauuuc                                                     18


<210> 7738
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7738
caaggaagau ggcauut                                                      17


<210> 7739
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7739
caaggaagau ggcaut                                                       16


<210> 7740
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7740
caaggaagau ggcat                                                        15


<210> 7741
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7741
caaggaagau ggca                                                         14


<210> 7742
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7742
caaggaagau ggc                                                          13


<210> 7743
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7743
caaggaagau gg                                                           12


<210> 7744
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7744
caaggaagau g                                                            11


<210> 7745
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7745
caaggaagat                                                              10


<210> 7746
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7746
caaggaaga                                                                9


<210> 7747
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7747
caaggaag                                                                 8


<210> 7748
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7748
aaggaagaug gcauuucuag                                                   20


<210> 7749
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7749
aaggaagaug gcauuucua                                                    19


<210> 7750
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7750
aaggaagaug gcauuuct                                                     18


<210> 7751
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7751
aaggaagaug gcauuuc                                                      17


<210> 7752
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7752
aaggaagaug gcauut                                                       16


<210> 7753
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7753
aaggaagaug gcaut                                                        15


<210> 7754
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7754
aaggaagaug gcat                                                         14


<210> 7755
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7755
aaggaagaug gca                                                          13


<210> 7756
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7756
aaggaagaug gc                                                           12


<210> 7757
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7757
aaggaagaug g                                                            11


<210> 7758
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7758
aaggaagaug                                                              10


<210> 7759
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7759
aaggaagat                                                                9


<210> 7760
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7760
aaggaaga                                                                 8


<210> 7761
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7761
aggaagaugg cauuucuag                                                    19


<210> 7762
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7762
aggaagaugg cauuucua                                                     18


<210> 7763
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7763
aggaagaugg cauuuct                                                      17


<210> 7764
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7764
aggaagaugg cauuuc                                                       16


<210> 7765
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7765
aggaagaugg cauut                                                        15


<210> 7766
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7766
aggaagaugg caut                                                         14


<210> 7767
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7767
aggaagaugg cat                                                          13


<210> 7768
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7768
aggaagaugg ca                                                           12


<210> 7769
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7769
aggaagaugg                                                              10


<210> 7770
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7770
aggaagaug                                                                9


<210> 7771
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7771
aggaagat                                                                 8


<210> 7772
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7772
ggaagauggc auuucuag                                                     18


<210> 7773
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7773
ggaagauggc auuucua                                                      17


<210> 7774
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7774
ggaagauggc auuuct                                                       16


<210> 7775
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7775
ggaagauggc auuuc                                                        15


<210> 7776
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7776
ggaagauggc auut                                                         14


<210> 7777
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7777
ggaagauggc aut                                                          13


<210> 7778
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7778
ggaagauggc at                                                           12


<210> 7779
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7779
ggaagauggc a                                                            11


<210> 7780
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7780
ggaagauggc                                                              10


<210> 7781
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7781
ggaagaug                                                                 8


<210> 7782
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7782
gaagauggca uuucuag                                                      17


<210> 7783
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7783
gaagauggca uuucua                                                       16


<210> 7784
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7784
gaagauggca uuuc                                                         14


<210> 7785
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7785
gaagauggca uut                                                          13


<210> 7786
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7786
gaagauggca ut                                                           12


<210> 7787
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7787
gaagauggca t                                                            11


<210> 7788
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7788
gaagauggca                                                              10


<210> 7789
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7789
gaagauggc                                                                9


<210> 7790
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7790
gaagaugg                                                                 8


<210> 7791
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7791
aagauggcau uucuag                                                       16


<210> 7792
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7792
aagauggcau uucua                                                        15


<210> 7793
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7793
aagauggcau uuct                                                         14


<210> 7794
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7794
aagauggcau uuc                                                          13


<210> 7795
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7795
aagauggcau ut                                                           12


<210> 7796
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7796
aagauggcau t                                                            11


<210> 7797
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7797
aagauggcat                                                              10


<210> 7798
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7798
aagauggca                                                                9


<210> 7799
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7799
aagauggc                                                                 8


<210> 7800
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7800
agauggcauu ucuag                                                        15


<210> 7801
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7801
agauggcauu ucua                                                         14


<210> 7802
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7802
agauggcauu uct                                                          13


<210> 7803
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7803
agauggcauu uc                                                           12


<210> 7804
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7804
agauggcauu t                                                            11


<210> 7805
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7805
agauggcaut                                                              10


<210> 7806
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7806
agauggcat                                                                9


<210> 7807
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7807
agauggca                                                                 8


<210> 7808
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7808
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 7809
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7809
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 7810
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7810
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 7811
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7811
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 7812
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7812
cuccaacauc aaggaagaug gcauut                                            26


<210> 7813
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7813
cuccaacauc aaggaagaug gcaut                                             25


<210> 7814
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7814
cuccaacauc aaggaagaug gcat                                              24


<210> 7815
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7815
cuccaacauc aaggaagaug gca                                               23


<210> 7816
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7816
cuccaacauc aaggaagaug gc                                                22


<210> 7817
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7817
cuccaacauc aaggaagaug g                                                 21


<210> 7818
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7818
cuccaacauc aaggaagaug                                                   20


<210> 7819
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7819
cuccaacauc aaggaagat                                                    19


<210> 7820
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7820
cuccaacauc aaggaaga                                                     18


<210> 7821
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7821
cuccaacauc aaggaag                                                      17


<210> 7822
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7822
tccaacauca aggaagaugg cauuucuag                                         29


<210> 7823
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7823
tccaacauca aggaagaugg cauuucua                                          28


<210> 7824
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7824
tccaacauca aggaagaugg cauuuct                                           27


<210> 7825
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7825
tccaacauca aggaagaugg cauuuc                                            26


<210> 7826
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7826
tccaacauca aggaagaugg cauut                                             25


<210> 7827
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7827
tccaacauca aggaagaugg caut                                              24


<210> 7828
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7828
tccaacauca aggaagaugg cat                                               23


<210> 7829
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7829
tccaacauca aggaagaugg ca                                                22


<210> 7830
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7830
tccaacauca aggaagaugg c                                                 21


<210> 7831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7831
tccaacauca aggaagaugg                                                   20


<210> 7832
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7832
tccaacauca aggaagaug                                                    19


<210> 7833
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7833
tccaacauca aggaagat                                                     18


<210> 7834
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7834
tccaacauca aggaaga                                                      17


<210> 7835
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7835
tccaacauca aggaag                                                       16


<210> 7836
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7836
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 7837
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7837
ccaacaucaa ggaagauggc auuucua                                           27


<210> 7838
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7838
ccaacaucaa ggaagauggc auuuct                                            26


<210> 7839
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7839
ccaacaucaa ggaagauggc auuuc                                             25


<210> 7840
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7840
ccaacaucaa ggaagauggc auut                                              24


<210> 7841
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7841
ccaacaucaa ggaagauggc aut                                               23


<210> 7842
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7842
ccaacaucaa ggaagauggc at                                                22


<210> 7843
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7843
ccaacaucaa ggaagauggc a                                                 21


<210> 7844
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7844
ccaacaucaa ggaagauggc                                                   20


<210> 7845
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7845
ccaacaucaa ggaagaugg                                                    19


<210> 7846
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7846
ccaacaucaa ggaagaug                                                     18


<210> 7847
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7847
ccaacaucaa ggaagat                                                      17


<210> 7848
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7848
ccaacaucaa ggaaga                                                       16


<210> 7849
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7849
ccaacaucaa ggaag                                                        15


<210> 7850
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7850
caacaucaag gaagauggca uuucuag                                           27


<210> 7851
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7851
caacaucaag gaagauggca uuucua                                            26


<210> 7852
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7852
caacaucaag gaagauggca uuuct                                             25


<210> 7853
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7853
caacaucaag gaagauggca uuuc                                              24


<210> 7854
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7854
caacaucaag gaagauggca uut                                               23


<210> 7855
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7855
caacaucaag gaagauggca ut                                                22


<210> 7856
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7856
caacaucaag gaagauggca t                                                 21


<210> 7857
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7857
caacaucaag gaagauggca                                                   20


<210> 7858
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7858
caacaucaag gaagauggc                                                    19


<210> 7859
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7859
caacaucaag gaagaugg                                                     18


<210> 7860
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7860
caacaucaag gaagaug                                                      17


<210> 7861
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7861
caacaucaag gaagat                                                       16


<210> 7862
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7862
caacaucaag gaaga                                                        15


<210> 7863
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7863
caacaucaag gaag                                                         14


<210> 7864
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7864
aacaucaagg aagauggcau uucuag                                            26


<210> 7865
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7865
aacaucaagg aagauggcau uucua                                             25


<210> 7866
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7866
aacaucaagg aagauggcau uuct                                              24


<210> 7867
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7867
aacaucaagg aagauggcau uuc                                               23


<210> 7868
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7868
aacaucaagg aagauggcau ut                                                22


<210> 7869
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7869
aacaucaagg aagauggcau t                                                 21


<210> 7870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7870
aacaucaagg aagauggcat                                                   20


<210> 7871
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7871
aacaucaagg aagauggca                                                    19


<210> 7872
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7872
aacaucaagg aagauggc                                                     18


<210> 7873
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7873
aacaucaagg aagaugg                                                      17


<210> 7874
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7874
aacaucaagg aagaug                                                       16


<210> 7875
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7875
aacaucaagg aagat                                                        15


<210> 7876
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7876
aacaucaagg aaga                                                         14


<210> 7877
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7877
aacaucaagg aag                                                          13


<210> 7878
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7878
acaucaagga agauggcauu ucuag                                             25


<210> 7879
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7879
acaucaagga agauggcauu ucua                                              24


<210> 7880
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7880
acaucaagga agauggcauu uct                                               23


<210> 7881
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7881
acaucaagga agauggcauu uc                                                22


<210> 7882
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7882
acaucaagga agauggcauu t                                                 21


<210> 7883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7883
acaucaagga agauggcaut                                                   20


<210> 7884
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7884
acaucaagga agauggcat                                                    19


<210> 7885
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7885
acaucaagga agauggca                                                     18


<210> 7886
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7886
acaucaagga agauggc                                                      17


<210> 7887
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7887
acaucaagga agaugg                                                       16


<210> 7888
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7888
acaucaagga agaug                                                        15


<210> 7889
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7889
acaucaagga agat                                                         14


<210> 7890
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7890
acaucaagga aga                                                          13


<210> 7891
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7891
acaucaagga ag                                                           12


<210> 7892
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7892
caucaaggaa gauggcauuu cuag                                              24


<210> 7893
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7893
caucaaggaa gauggcauuu cua                                               23


<210> 7894
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7894
caucaaggaa gauggcauuu ct                                                22


<210> 7895
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7895
caucaaggaa gauggcauuu c                                                 21


<210> 7896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7896
caucaaggaa gauggcauut                                                   20


<210> 7897
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7897
caucaaggaa gauggcaut                                                    19


<210> 7898
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7898
caucaaggaa gauggcat                                                     18


<210> 7899
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7899
caucaaggaa gauggca                                                      17


<210> 7900
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7900
caucaaggaa gauggc                                                       16


<210> 7901
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7901
caucaaggaa gaugg                                                        15


<210> 7902
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7902
caucaaggaa gaug                                                         14


<210> 7903
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7903
caucaaggaa gat                                                          13


<210> 7904
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7904
caucaaggaa ga                                                           12


<210> 7905
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7905
caucaaggaa g                                                            11


<210> 7906
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7906
aucaaggaag auggcauuuc uag                                               23


<210> 7907
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7907
aucaaggaag auggcauuuc ua                                                22


<210> 7908
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7908
aucaaggaag auggcauuuc t                                                 21


<210> 7909
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7909
aucaaggaag auggcauuuc                                                   20


<210> 7910
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7910
aucaaggaag auggcauut                                                    19


<210> 7911
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7911
aucaaggaag auggcaut                                                     18


<210> 7912
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7912
aucaaggaag auggcat                                                      17


<210> 7913
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7913
aucaaggaag auggca                                                       16


<210> 7914
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7914
aucaaggaag auggc                                                        15


<210> 7915
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7915
aucaaggaag augg                                                         14


<210> 7916
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7916
aucaaggaag aug                                                          13


<210> 7917
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7917
aucaaggaag at                                                           12


<210> 7918
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7918
aucaaggaag a                                                            11


<210> 7919
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7919
aucaaggaag                                                              10


<210> 7920
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7920
ccagagcagg uaccuccaac auc                                               23


<210> 7921
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7921
ccagagcagg uaccucca                                                     18


<210> 7922
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7922
ccucugugau uuuauaacuu gat                                               23


<210> 7923
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7923
tcacccacca ucaccct                                                      17


<210> 7924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7924
tgauauccuc aaggucaccc                                                   20


<210> 7925
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7925
cugcuugaug aucaucucgu ug                                                22


<210> 7926
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7926
cugcuugaug aucaucuc                                                     18


<210> 7927
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7927
guuuccuuag uaaccacag                                                    19


<210> 7928
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 7928
guuuccuuag uaaccac                                                      17


<210> 7929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7929
tcaaggaaga uggcauuucu                                                   20


<210> 7930
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7930
tcaaggaaga uggcauuucu ag                                                22


<210> 7931
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7931
gguaaguucu guccaagc                                                     18


<210> 7932
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7932
gtaaguucug uccaagcc                                                     18


<210> 7933
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7933
agucgguaag uucugucc                                                     18


<210> 7934
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7934
ctguccaagc ccgguuga                                                     18


<210> 7935
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7935
taaguucugu ccaag                                                        15


<210> 7936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7936
ttcuguccaa gcccgguuga                                                   20


<210> 7937
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7937
ttcuguccaa gcccgguug                                                    19


<210> 7938
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7938
ttcuguccaa gcccgguu                                                     18


<210> 7939
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7939
ttcuguccaa gcccggu                                                      17


<210> 7940
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7940
ttcuguccaa gcccgg                                                       16


<210> 7941
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7941
ttcuguccaa gcccg                                                        15


<210> 7942
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7942
ttcuguccaa gccc                                                         14


<210> 7943
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7943
ttcuguccaa gcc                                                          13


<210> 7944
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7944
ttcuguccaa gc                                                           12


<210> 7945
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7945
ttcuguccaa g                                                            11


<210> 7946
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7946
ttcuguccaa                                                              10


<210> 7947
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7947
ttcugucca                                                                9


<210> 7948
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7948
ttcugucc                                                                 8


<210> 7949
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7949
tcuguccaag cccgguuga                                                    19


<210> 7950
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7950
tcuguccaag cccgguug                                                     18


<210> 7951
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7951
tcuguccaag cccgguu                                                      17


<210> 7952
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7952
tcuguccaag cccggu                                                       16


<210> 7953
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7953
tcuguccaag cccgg                                                        15


<210> 7954
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7954
tcuguccaag cccg                                                         14


<210> 7955
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7955
tcuguccaag ccc                                                          13


<210> 7956
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7956
tcuguccaag cc                                                           12


<210> 7957
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7957
tcuguccaag c                                                            11


<210> 7958
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7958
tcuguccaag                                                              10


<210> 7959
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7959
tcuguccaa                                                                9


<210> 7960
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7960
tcugucca                                                                 8


<210> 7961
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7961
ctguccaagc ccgguug                                                      17


<210> 7962
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7962
ctguccaagc ccgguu                                                       16


<210> 7963
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7963
ctguccaagc ccggu                                                        15


<210> 7964
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7964
ctguccaagc ccgg                                                         14


<210> 7965
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7965
ctguccaagc ccg                                                          13


<210> 7966
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7966
ctguccaagc cc                                                           12


<210> 7967
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7967
ctguccaagc c                                                            11


<210> 7968
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7968
ctguccaagc                                                              10


<210> 7969
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7969
ctguccaag                                                                9


<210> 7970
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7970
ctguccaa                                                                 8


<210> 7971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7971
gtucugucca agcccgguug                                                   20


<210> 7972
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7972
gtucugucca agcccgguu                                                    19


<210> 7973
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7973
gtucugucca agcccggu                                                     18


<210> 7974
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7974
gtucugucca agcccgg                                                      17


<210> 7975
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7975
gtucugucca agcccg                                                       16


<210> 7976
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7976
gtucugucca agccc                                                        15


<210> 7977
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7977
gtucugucca agcc                                                         14


<210> 7978
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7978
gtucugucca agc                                                          13


<210> 7979
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7979
gtucugucca ag                                                           12


<210> 7980
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7980
gtucugucca a                                                            11


<210> 7981
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7981
gtucugucca                                                              10


<210> 7982
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7982
gtucugucc                                                                9


<210> 7983
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7983
gtucuguc                                                                 8


<210> 7984
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7984
aguucugucc aagcccgguu                                                   20


<210> 7985
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7985
aguucugucc aagcccggu                                                    19


<210> 7986
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7986
aguucugucc aagcccgg                                                     18


<210> 7987
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7987
aguucugucc aagcccg                                                      17


<210> 7988
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7988
aguucugucc aagccc                                                       16


<210> 7989
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7989
aguucugucc aagcc                                                        15


<210> 7990
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7990
aguucugucc aagc                                                         14


<210> 7991
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7991
aguucugucc aag                                                          13


<210> 7992
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7992
aguucugucc aa                                                           12


<210> 7993
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7993
aguucugucc a                                                            11


<210> 7994
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7994
aguucugucc                                                              10


<210> 7995
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7995
aguucuguc                                                                9


<210> 7996
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7996
aguucugu                                                                 8


<210> 7997
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7997
aaguucuguc caagcccggu                                                   20


<210> 7998
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7998
aaguucuguc caagcccgg                                                    19


<210> 7999
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 7999
aaguucuguc caagcccg                                                     18


<210> 8000
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8000
aaguucuguc caagccc                                                      17


<210> 8001
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8001
aaguucuguc caagcc                                                       16


<210> 8002
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8002
aaguucuguc caagc                                                        15


<210> 8003
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8003
aaguucuguc caag                                                         14


<210> 8004
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8004
aaguucuguc caa                                                          13


<210> 8005
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8005
aaguucuguc ca                                                           12


<210> 8006
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8006
aaguucuguc c                                                            11


<210> 8007
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8007
aaguucuguc                                                              10


<210> 8008
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8008
aaguucugu                                                                9


<210> 8009
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8009
aaguucug                                                                 8


<210> 8010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8010
taaguucugu ccaagcccgg                                                   20


<210> 8011
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8011
taaguucugu ccaagcccg                                                    19


<210> 8012
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8012
taaguucugu ccaagccc                                                     18


<210> 8013
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8013
taaguucugu ccaagcc                                                      17


<210> 8014
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8014
taaguucugu ccaagc                                                       16


<210> 8015
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8015
taaguucugu ccaa                                                         14


<210> 8016
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8016
taaguucugu cca                                                          13


<210> 8017
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8017
taaguucugu cc                                                           12


<210> 8018
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8018
taaguucugu c                                                            11


<210> 8019
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8019
taaguucugu                                                              10


<210> 8020
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8020
taaguucug                                                                9


<210> 8021
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8021
taaguucu                                                                 8


<210> 8022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8022
gtaaguucug uccaagcccg                                                   20


<210> 8023
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8023
gtaaguucug uccaagccc                                                    19


<210> 8024
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8024
gtaaguucug uccaagc                                                      17


<210> 8025
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8025
gtaaguucug uccaag                                                       16


<210> 8026
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8026
gtaaguucug uccaa                                                        15


<210> 8027
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8027
gtaaguucug ucca                                                         14


<210> 8028
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8028
gtaaguucug ucc                                                          13


<210> 8029
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8029
gtaaguucug uc                                                           12


<210> 8030
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8030
gtaaguucug u                                                            11


<210> 8031
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8031
gtaaguucug                                                              10


<210> 8032
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8032
gtaaguucu                                                                9


<210> 8033
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8033
gtaaguuc                                                                 8


<210> 8034
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8034
gguaaguucu guccaagccc                                                   20


<210> 8035
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8035
gguaaguucu guccaagcc                                                    19


<210> 8036
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8036
gguaaguucu guccaag                                                      17


<210> 8037
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8037
gguaaguucu guccaa                                                       16


<210> 8038
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8038
gguaaguucu gucca                                                        15


<210> 8039
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8039
gguaaguucu gucc                                                         14


<210> 8040
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8040
gguaaguucu guc                                                          13


<210> 8041
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8041
gguaaguucu gu                                                           12


<210> 8042
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8042
gguaaguucu g                                                            11


<210> 8043
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8043
gguaaguucu                                                              10


<210> 8044
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8044
gguaaguuc                                                                9


<210> 8045
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8045
gguaaguu                                                                 8


<210> 8046
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8046
cgguaaguuc uguccaagcc                                                   20


<210> 8047
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8047
cgguaaguuc uguccaagc                                                    19


<210> 8048
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8048
cgguaaguuc uguccaag                                                     18


<210> 8049
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8049
cgguaaguuc uguccaa                                                      17


<210> 8050
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8050
cgguaaguuc ugucca                                                       16


<210> 8051
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8051
cgguaaguuc ugucc                                                        15


<210> 8052
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8052
cgguaaguuc uguc                                                         14


<210> 8053
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8053
cgguaaguuc ugu                                                          13


<210> 8054
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8054
cgguaaguuc ug                                                           12


<210> 8055
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8055
cgguaaguuc u                                                            11


<210> 8056
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8056
cgguaaguuc                                                              10


<210> 8057
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8057
cgguaaguu                                                                9


<210> 8058
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8058
cgguaagu                                                                 8


<210> 8059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8059
tcgguaaguu cuguccaagc                                                   20


<210> 8060
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8060
tcgguaaguu cuguccaag                                                    19


<210> 8061
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8061
tcgguaaguu cuguccaa                                                     18


<210> 8062
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8062
tcgguaaguu cugucca                                                      17


<210> 8063
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8063
tcgguaaguu cugucc                                                       16


<210> 8064
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8064
tcgguaaguu cuguc                                                        15


<210> 8065
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8065
tcgguaaguu cugu                                                         14


<210> 8066
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8066
tcgguaaguu cug                                                          13


<210> 8067
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8067
tcgguaaguu cu                                                           12


<210> 8068
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8068
tcgguaaguu c                                                            11


<210> 8069
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8069
tcgguaaguu                                                              10


<210> 8070
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8070
tcgguaagu                                                                9


<210> 8071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8071
gtcgguaagu ucuguccaag                                                   20


<210> 8072
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8072
gtcgguaagu ucuguccaa                                                    19


<210> 8073
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8073
gtcgguaagu ucugucca                                                     18


<210> 8074
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8074
gtcgguaagu ucugucc                                                      17


<210> 8075
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8075
gtcgguaagu ucuguc                                                       16


<210> 8076
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8076
gtcgguaagu ucugu                                                        15


<210> 8077
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8077
gtcgguaagu ucug                                                         14


<210> 8078
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8078
gtcgguaagu ucu                                                          13


<210> 8079
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8079
gtcgguaagu uc                                                           12


<210> 8080
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8080
gtcgguaagu u                                                            11


<210> 8081
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8081
gtcgguaagu                                                              10


<210> 8082
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8082
agucgguaag uucuguccaa                                                   20


<210> 8083
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8083
agucgguaag uucugucca                                                    19


<210> 8084
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8084
agucgguaag uucuguc                                                      17


<210> 8085
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8085
agucgguaag uucugu                                                       16


<210> 8086
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8086
agucgguaag uucug                                                        15


<210> 8087
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8087
agucgguaag uucu                                                         14


<210> 8088
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8088
agucgguaag uuc                                                          13


<210> 8089
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8089
agucgguaag uu                                                           12


<210> 8090
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8090
agucgguaag u                                                            11


<210> 8091
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8091
cagucgguaa guucugucca                                                   20


<210> 8092
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8092
cagucgguaa guucugucc                                                    19


<210> 8093
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8093
cagucgguaa guucuguc                                                     18


<210> 8094
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8094
cagucgguaa guucugu                                                      17


<210> 8095
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8095
cagucgguaa guucug                                                       16


<210> 8096
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8096
cagucgguaa guucu                                                        15


<210> 8097
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8097
cagucgguaa guuc                                                         14


<210> 8098
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8098
cagucgguaa guu                                                          13


<210> 8099
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8099
cagucgguaa gu                                                           12


<210> 8100
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8100
ccagucggua aguucugucc                                                   20


<210> 8101
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8101
ccagucggua aguucuguc                                                    19


<210> 8102
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8102
ccagucggua aguucugu                                                     18


<210> 8103
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8103
ccagucggua aguucug                                                      17


<210> 8104
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8104
ccagucggua aguucu                                                       16


<210> 8105
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8105
ccagucggua aguuc                                                        15


<210> 8106
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8106
ccagucggua aguu                                                         14


<210> 8107
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8107
ccagucggua agu                                                          13


<210> 8108
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8108
gccagucggu aaguucuguc                                                   20


<210> 8109
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8109
gccagucggu aaguucugu                                                    19


<210> 8110
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8110
gccagucggu aaguucug                                                     18


<210> 8111
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8111
gccagucggu aaguucu                                                      17


<210> 8112
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8112
gccagucggu aaguuc                                                       16


<210> 8113
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8113
gccagucggu aaguu                                                        15


<210> 8114
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8114
gccagucggu aagu                                                         14


<210> 8115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8115
tcaaggaaga uggcauuucu                                                   20


<210> 8116
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8116
tcaaggaaga uggcauuucu ag                                                22


<210> 8117
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8117
tcaaggaaga uggcau                                                       16


<210> 8118
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8118
gaagauggca uuucu                                                        15


<210> 8119
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8119
tcaaggaaga uggcauuucu a                                                 21


<210> 8120
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8120
tcaaggaaga uggcauuuc                                                    19


<210> 8121
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8121
tcaaggaaga uggcauuu                                                     18


<210> 8122
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8122
tcaaggaaga uggcauu                                                      17


<210> 8123
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8123
tcaaggaaga uggca                                                        15


<210> 8124
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8124
tcaaggaaga uggc                                                         14


<210> 8125
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8125
tcaaggaaga ugg                                                          13


<210> 8126
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8126
tcaaggaaga ug                                                           12


<210> 8127
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8127
tcaaggaaga u                                                            11


<210> 8128
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8128
tcaaggaaga                                                              10


<210> 8129
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8129
tcaaggaag                                                                9


<210> 8130
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8130
caaggaagau ggcauuucua g                                                 21


<210> 8131
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8131
caaggaagau ggcauuucua                                                   20


<210> 8132
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8132
caaggaagau ggcauuucu                                                    19


<210> 8133
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8133
caaggaagau ggcauuuc                                                     18


<210> 8134
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8134
caaggaagau ggcauuu                                                      17


<210> 8135
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8135
caaggaagau ggcauu                                                       16


<210> 8136
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8136
caaggaagau ggcau                                                        15


<210> 8137
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8137
caaggaagau ggca                                                         14


<210> 8138
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8138
caaggaagau ggc                                                          13


<210> 8139
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8139
caaggaagau gg                                                           12


<210> 8140
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8140
caaggaagau g                                                            11


<210> 8141
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8141
caaggaagau                                                              10


<210> 8142
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8142
caaggaaga                                                                9


<210> 8143
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8143
caaggaag                                                                 8


<210> 8144
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8144
aaggaagaug gcauuucuag                                                   20


<210> 8145
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8145
aaggaagaug gcauuucua                                                    19


<210> 8146
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8146
aaggaagaug gcauuucu                                                     18


<210> 8147
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8147
aaggaagaug gcauuuc                                                      17


<210> 8148
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8148
aaggaagaug gcauuu                                                       16


<210> 8149
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8149
aaggaagaug gcauu                                                        15


<210> 8150
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8150
aaggaagaug gcau                                                         14


<210> 8151
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8151
aaggaagaug gca                                                          13


<210> 8152
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8152
aaggaagaug gc                                                           12


<210> 8153
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8153
aaggaagaug g                                                            11


<210> 8154
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8154
aaggaagaug                                                              10


<210> 8155
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8155
aaggaagau                                                                9


<210> 8156
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8156
aaggaaga                                                                 8


<210> 8157
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8157
aggaagaugg cauuucuag                                                    19


<210> 8158
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8158
aggaagaugg cauuucua                                                     18


<210> 8159
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8159
aggaagaugg cauuucu                                                      17


<210> 8160
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8160
aggaagaugg cauuuc                                                       16


<210> 8161
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8161
aggaagaugg cauuu                                                        15


<210> 8162
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8162
aggaagaugg cauu                                                         14


<210> 8163
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8163
aggaagaugg cau                                                          13


<210> 8164
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8164
aggaagaugg ca                                                           12


<210> 8165
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8165
aggaagaugg                                                              10


<210> 8166
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8166
aggaagaug                                                                9


<210> 8167
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8167
aggaagau                                                                 8


<210> 8168
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8168
ggaagauggc auuucuag                                                     18


<210> 8169
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8169
ggaagauggc auuucua                                                      17


<210> 8170
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8170
ggaagauggc auuucu                                                       16


<210> 8171
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8171
ggaagauggc auuuc                                                        15


<210> 8172
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8172
ggaagauggc auuu                                                         14


<210> 8173
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8173
ggaagauggc auu                                                          13


<210> 8174
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8174
ggaagauggc au                                                           12


<210> 8175
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8175
ggaagauggc a                                                            11


<210> 8176
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8176
ggaagauggc                                                              10


<210> 8177
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8177
ggaagaug                                                                 8


<210> 8178
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8178
gaagauggca uuucuag                                                      17


<210> 8179
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8179
gaagauggca uuucua                                                       16


<210> 8180
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8180
gaagauggca uuuc                                                         14


<210> 8181
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8181
gaagauggca uuu                                                          13


<210> 8182
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8182
gaagauggca uu                                                           12


<210> 8183
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8183
gaagauggca u                                                            11


<210> 8184
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8184
gaagauggca                                                              10


<210> 8185
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8185
gaagauggc                                                                9


<210> 8186
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8186
gaagaugg                                                                 8


<210> 8187
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8187
aagauggcau uucuag                                                       16


<210> 8188
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8188
aagauggcau uucua                                                        15


<210> 8189
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8189
aagauggcau uucu                                                         14


<210> 8190
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8190
aagauggcau uuc                                                          13


<210> 8191
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8191
aagauggcau uu                                                           12


<210> 8192
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8192
aagauggcau u                                                            11


<210> 8193
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8193
aagauggcau                                                              10


<210> 8194
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8194
aagauggca                                                                9


<210> 8195
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8195
aagauggc                                                                 8


<210> 8196
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8196
agauggcauu ucuag                                                        15


<210> 8197
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8197
agauggcauu ucua                                                         14


<210> 8198
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8198
agauggcauu ucu                                                          13


<210> 8199
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8199
agauggcauu uc                                                           12


<210> 8200
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8200
agauggcauu u                                                            11


<210> 8201
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8201
agauggcauu                                                              10


<210> 8202
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8202
agauggcau                                                                9


<210> 8203
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8203
agauggca                                                                 8


<210> 8204
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8204
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 8205
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8205
ctccaacauc aaggaagaug gcauuucua                                         29


<210> 8206
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8206
ctccaacauc aaggaagaug gcauuucu                                          28


<210> 8207
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8207
ctccaacauc aaggaagaug gcauuuc                                           27


<210> 8208
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8208
ctccaacauc aaggaagaug gcauuu                                            26


<210> 8209
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8209
ctccaacauc aaggaagaug gcauu                                             25


<210> 8210
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8210
ctccaacauc aaggaagaug gcau                                              24


<210> 8211
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8211
ctccaacauc aaggaagaug gca                                               23


<210> 8212
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8212
ctccaacauc aaggaagaug gc                                                22


<210> 8213
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8213
ctccaacauc aaggaagaug g                                                 21


<210> 8214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8214
ctccaacauc aaggaagaug                                                   20


<210> 8215
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8215
ctccaacauc aaggaagau                                                    19


<210> 8216
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8216
ctccaacauc aaggaaga                                                     18


<210> 8217
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8217
ctccaacauc aaggaag                                                      17


<210> 8218
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8218
tccaacauca aggaagaugg cauuucuag                                         29


<210> 8219
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8219
tccaacauca aggaagaugg cauuucua                                          28


<210> 8220
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8220
tccaacauca aggaagaugg cauuucu                                           27


<210> 8221
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8221
tccaacauca aggaagaugg cauuuc                                            26


<210> 8222
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8222
tccaacauca aggaagaugg cauuu                                             25


<210> 8223
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8223
tccaacauca aggaagaugg cauu                                              24


<210> 8224
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8224
tccaacauca aggaagaugg cau                                               23


<210> 8225
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8225
tccaacauca aggaagaugg ca                                                22


<210> 8226
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8226
tccaacauca aggaagaugg c                                                 21


<210> 8227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8227
tccaacauca aggaagaugg                                                   20


<210> 8228
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8228
tccaacauca aggaagaug                                                    19


<210> 8229
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8229
tccaacauca aggaagau                                                     18


<210> 8230
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8230
tccaacauca aggaaga                                                      17


<210> 8231
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8231
tccaacauca aggaag                                                       16


<210> 8232
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8232
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 8233
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8233
ccaacaucaa ggaagauggc auuucua                                           27


<210> 8234
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8234
ccaacaucaa ggaagauggc auuucu                                            26


<210> 8235
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8235
ccaacaucaa ggaagauggc auuuc                                             25


<210> 8236
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8236
ccaacaucaa ggaagauggc auuu                                              24


<210> 8237
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8237
ccaacaucaa ggaagauggc auu                                               23


<210> 8238
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8238
ccaacaucaa ggaagauggc au                                                22


<210> 8239
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8239
ccaacaucaa ggaagauggc a                                                 21


<210> 8240
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8240
ccaacaucaa ggaagauggc                                                   20


<210> 8241
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8241
ccaacaucaa ggaagaugg                                                    19


<210> 8242
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8242
ccaacaucaa ggaagaug                                                     18


<210> 8243
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8243
ccaacaucaa ggaagau                                                      17


<210> 8244
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8244
ccaacaucaa ggaaga                                                       16


<210> 8245
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8245
ccaacaucaa ggaag                                                        15


<210> 8246
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8246
caacaucaag gaagauggca uuucuag                                           27


<210> 8247
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8247
caacaucaag gaagauggca uuucua                                            26


<210> 8248
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8248
caacaucaag gaagauggca uuucu                                             25


<210> 8249
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8249
caacaucaag gaagauggca uuuc                                              24


<210> 8250
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8250
caacaucaag gaagauggca uuu                                               23


<210> 8251
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8251
caacaucaag gaagauggca uu                                                22


<210> 8252
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8252
caacaucaag gaagauggca u                                                 21


<210> 8253
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8253
caacaucaag gaagauggca                                                   20


<210> 8254
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8254
caacaucaag gaagauggc                                                    19


<210> 8255
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8255
caacaucaag gaagaugg                                                     18


<210> 8256
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8256
caacaucaag gaagaug                                                      17


<210> 8257
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8257
caacaucaag gaagau                                                       16


<210> 8258
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8258
caacaucaag gaaga                                                        15


<210> 8259
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8259
caacaucaag gaag                                                         14


<210> 8260
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8260
aacaucaagg aagauggcau uucuag                                            26


<210> 8261
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8261
aacaucaagg aagauggcau uucua                                             25


<210> 8262
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8262
aacaucaagg aagauggcau uucu                                              24


<210> 8263
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8263
aacaucaagg aagauggcau uuc                                               23


<210> 8264
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8264
aacaucaagg aagauggcau uu                                                22


<210> 8265
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8265
aacaucaagg aagauggcau u                                                 21


<210> 8266
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8266
aacaucaagg aagauggcau                                                   20


<210> 8267
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8267
aacaucaagg aagauggca                                                    19


<210> 8268
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8268
aacaucaagg aagauggc                                                     18


<210> 8269
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8269
aacaucaagg aagaugg                                                      17


<210> 8270
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8270
aacaucaagg aagaug                                                       16


<210> 8271
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8271
aacaucaagg aagau                                                        15


<210> 8272
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8272
aacaucaagg aaga                                                         14


<210> 8273
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8273
aacaucaagg aag                                                          13


<210> 8274
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8274
acaucaagga agauggcauu ucuag                                             25


<210> 8275
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8275
acaucaagga agauggcauu ucua                                              24


<210> 8276
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8276
acaucaagga agauggcauu ucu                                               23


<210> 8277
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8277
acaucaagga agauggcauu uc                                                22


<210> 8278
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8278
acaucaagga agauggcauu u                                                 21


<210> 8279
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8279
acaucaagga agauggcauu                                                   20


<210> 8280
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8280
acaucaagga agauggcau                                                    19


<210> 8281
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8281
acaucaagga agauggca                                                     18


<210> 8282
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8282
acaucaagga agauggc                                                      17


<210> 8283
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8283
acaucaagga agaugg                                                       16


<210> 8284
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8284
acaucaagga agaug                                                        15


<210> 8285
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8285
acaucaagga agau                                                         14


<210> 8286
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8286
acaucaagga aga                                                          13


<210> 8287
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8287
acaucaagga ag                                                           12


<210> 8288
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8288
caucaaggaa gauggcauuu cuag                                              24


<210> 8289
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8289
caucaaggaa gauggcauuu cua                                               23


<210> 8290
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8290
caucaaggaa gauggcauuu cu                                                22


<210> 8291
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8291
caucaaggaa gauggcauuu c                                                 21


<210> 8292
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8292
caucaaggaa gauggcauuu                                                   20


<210> 8293
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8293
caucaaggaa gauggcauu                                                    19


<210> 8294
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8294
caucaaggaa gauggcau                                                     18


<210> 8295
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8295
caucaaggaa gauggca                                                      17


<210> 8296
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8296
caucaaggaa gauggc                                                       16


<210> 8297
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8297
caucaaggaa gaugg                                                        15


<210> 8298
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8298
caucaaggaa gaug                                                         14


<210> 8299
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8299
caucaaggaa gau                                                          13


<210> 8300
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8300
caucaaggaa ga                                                           12


<210> 8301
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8301
caucaaggaa g                                                            11


<210> 8302
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8302
atcaaggaag auggcauuuc uag                                               23


<210> 8303
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8303
atcaaggaag auggcauuuc ua                                                22


<210> 8304
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8304
atcaaggaag auggcauuuc u                                                 21


<210> 8305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8305
atcaaggaag auggcauuuc                                                   20


<210> 8306
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8306
atcaaggaag auggcauuu                                                    19


<210> 8307
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8307
atcaaggaag auggcauu                                                     18


<210> 8308
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8308
atcaaggaag auggcau                                                      17


<210> 8309
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8309
atcaaggaag auggca                                                       16


<210> 8310
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8310
atcaaggaag auggc                                                        15


<210> 8311
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8311
atcaaggaag augg                                                         14


<210> 8312
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8312
atcaaggaag aug                                                          13


<210> 8313
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8313
atcaaggaag au                                                           12


<210> 8314
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8314
atcaaggaag a                                                            11


<210> 8315
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8315
atcaaggaag                                                              10


<210> 8316
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8316
ccagagcagg uaccuccaac auc                                               23


<210> 8317
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8317
ccagagcagg uaccucca                                                     18


<210> 8318
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8318
ccucugugau uuuauaacuu gau                                               23


<210> 8319
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8319
tcacccacca ucacccu                                                      17


<210> 8320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8320
tgauauccuc aaggucaccc                                                   20


<210> 8321
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8321
ctgcuugaug aucaucucgu ug                                                22


<210> 8322
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8322
ctgcuugaug aucaucuc                                                     18


<210> 8323
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8323
gtuuccuuag uaaccacag                                                    19


<210> 8324
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8324
gtuuccuuag uaaccac                                                      17


<210> 8325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8325
tcaaggaaga uggcauuucu                                                   20


<210> 8326
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8326
tcaaggaaga uggcauuucu ag                                                22


<210> 8327
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8327
gguaaguucu guccaagc                                                     18


<210> 8328
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8328
gtaaguucug uccaagcc                                                     18


<210> 8329
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8329
agucgguaag uucugucc                                                     18


<210> 8330
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8330
ctguccaagc ccgguuga                                                     18


<210> 8331
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8331
taaguucugu ccaag                                                        15


<210> 8332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8332
ttcuguccaa gcccgguuga                                                   20


<210> 8333
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8333
ttcuguccaa gcccgguug                                                    19


<210> 8334
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8334
ttcuguccaa gcccgguu                                                     18


<210> 8335
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8335
ttcuguccaa gcccggu                                                      17


<210> 8336
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8336
ttcuguccaa gcccgg                                                       16


<210> 8337
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8337
ttcuguccaa gcccg                                                        15


<210> 8338
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8338
ttcuguccaa gccc                                                         14


<210> 8339
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8339
ttcuguccaa gcc                                                          13


<210> 8340
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8340
ttcuguccaa gc                                                           12


<210> 8341
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8341
ttcuguccaa g                                                            11


<210> 8342
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8342
ttcuguccaa                                                              10


<210> 8343
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8343
ttcugucca                                                                9


<210> 8344
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8344
ttcugucc                                                                 8


<210> 8345
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8345
tcuguccaag cccgguuga                                                    19


<210> 8346
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8346
tcuguccaag cccgguug                                                     18


<210> 8347
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8347
tcuguccaag cccgguu                                                      17


<210> 8348
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8348
tcuguccaag cccggu                                                       16


<210> 8349
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8349
tcuguccaag cccgg                                                        15


<210> 8350
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8350
tcuguccaag cccg                                                         14


<210> 8351
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8351
tcuguccaag ccc                                                          13


<210> 8352
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8352
tcuguccaag cc                                                           12


<210> 8353
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8353
tcuguccaag c                                                            11


<210> 8354
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8354
tcuguccaag                                                              10


<210> 8355
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8355
tcuguccaa                                                                9


<210> 8356
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8356
tcugucca                                                                 8


<210> 8357
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8357
ctguccaagc ccgguug                                                      17


<210> 8358
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8358
ctguccaagc ccgguu                                                       16


<210> 8359
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8359
ctguccaagc ccggu                                                        15


<210> 8360
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8360
ctguccaagc ccgg                                                         14


<210> 8361
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8361
ctguccaagc ccg                                                          13


<210> 8362
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8362
ctguccaagc cc                                                           12


<210> 8363
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8363
ctguccaagc c                                                            11


<210> 8364
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8364
ctguccaagc                                                              10


<210> 8365
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8365
ctguccaag                                                                9


<210> 8366
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8366
ctguccaa                                                                 8


<210> 8367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8367
gtucugucca agcccgguug                                                   20


<210> 8368
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8368
gtucugucca agcccgguu                                                    19


<210> 8369
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8369
gtucugucca agcccggu                                                     18


<210> 8370
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8370
gtucugucca agcccgg                                                      17


<210> 8371
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8371
gtucugucca agcccg                                                       16


<210> 8372
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8372
gtucugucca agccc                                                        15


<210> 8373
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8373
gtucugucca agcc                                                         14


<210> 8374
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8374
gtucugucca agc                                                          13


<210> 8375
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8375
gtucugucca ag                                                           12


<210> 8376
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8376
gtucugucca a                                                            11


<210> 8377
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8377
gtucugucca                                                              10


<210> 8378
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8378
gtucugucc                                                                9


<210> 8379
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8379
gtucuguc                                                                 8


<210> 8380
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8380
aguucugucc aagcccgguu                                                   20


<210> 8381
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8381
aguucugucc aagcccggu                                                    19


<210> 8382
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8382
aguucugucc aagcccgg                                                     18


<210> 8383
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8383
aguucugucc aagcccg                                                      17


<210> 8384
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8384
aguucugucc aagccc                                                       16


<210> 8385
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8385
aguucugucc aagcc                                                        15


<210> 8386
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8386
aguucugucc aagc                                                         14


<210> 8387
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8387
aguucugucc aag                                                          13


<210> 8388
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8388
aguucugucc aa                                                           12


<210> 8389
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8389
aguucugucc a                                                            11


<210> 8390
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8390
aguucugucc                                                              10


<210> 8391
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8391
aguucuguc                                                                9


<210> 8392
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8392
aguucugu                                                                 8


<210> 8393
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8393
aaguucuguc caagcccggu                                                   20


<210> 8394
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8394
aaguucuguc caagcccgg                                                    19


<210> 8395
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8395
aaguucuguc caagcccg                                                     18


<210> 8396
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8396
aaguucuguc caagccc                                                      17


<210> 8397
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8397
aaguucuguc caagcc                                                       16


<210> 8398
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8398
aaguucuguc caagc                                                        15


<210> 8399
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8399
aaguucuguc caag                                                         14


<210> 8400
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8400
aaguucuguc caa                                                          13


<210> 8401
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8401
aaguucuguc ca                                                           12


<210> 8402
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8402
aaguucuguc c                                                            11


<210> 8403
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8403
aaguucuguc                                                              10


<210> 8404
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8404
aaguucugu                                                                9


<210> 8405
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8405
aaguucug                                                                 8


<210> 8406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8406
taaguucugu ccaagcccgg                                                   20


<210> 8407
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8407
taaguucugu ccaagcccg                                                    19


<210> 8408
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8408
taaguucugu ccaagccc                                                     18


<210> 8409
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8409
taaguucugu ccaagcc                                                      17


<210> 8410
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8410
taaguucugu ccaagc                                                       16


<210> 8411
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8411
taaguucugu ccaa                                                         14


<210> 8412
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8412
taaguucugu cca                                                          13


<210> 8413
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8413
taaguucugu cc                                                           12


<210> 8414
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8414
taaguucugu c                                                            11


<210> 8415
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8415
taaguucugu                                                              10


<210> 8416
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8416
taaguucug                                                                9


<210> 8417
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8417
taaguucu                                                                 8


<210> 8418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8418
gtaaguucug uccaagcccg                                                   20


<210> 8419
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8419
gtaaguucug uccaagccc                                                    19


<210> 8420
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8420
gtaaguucug uccaagc                                                      17


<210> 8421
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8421
gtaaguucug uccaag                                                       16


<210> 8422
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8422
gtaaguucug uccaa                                                        15


<210> 8423
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8423
gtaaguucug ucca                                                         14


<210> 8424
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8424
gtaaguucug ucc                                                          13


<210> 8425
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8425
gtaaguucug uc                                                           12


<210> 8426
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8426
gtaaguucug u                                                            11


<210> 8427
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8427
gtaaguucug                                                              10


<210> 8428
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8428
gtaaguucu                                                                9


<210> 8429
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8429
gtaaguuc                                                                 8


<210> 8430
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8430
gguaaguucu guccaagccc                                                   20


<210> 8431
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8431
gguaaguucu guccaagcc                                                    19


<210> 8432
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8432
gguaaguucu guccaag                                                      17


<210> 8433
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8433
gguaaguucu guccaa                                                       16


<210> 8434
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8434
gguaaguucu gucca                                                        15


<210> 8435
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8435
gguaaguucu gucc                                                         14


<210> 8436
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8436
gguaaguucu guc                                                          13


<210> 8437
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8437
gguaaguucu gu                                                           12


<210> 8438
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8438
gguaaguucu g                                                            11


<210> 8439
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8439
gguaaguucu                                                              10


<210> 8440
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8440
gguaaguuc                                                                9


<210> 8441
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8441
gguaaguu                                                                 8


<210> 8442
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8442
cgguaaguuc uguccaagcc                                                   20


<210> 8443
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8443
cgguaaguuc uguccaagc                                                    19


<210> 8444
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8444
cgguaaguuc uguccaag                                                     18


<210> 8445
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8445
cgguaaguuc uguccaa                                                      17


<210> 8446
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8446
cgguaaguuc ugucca                                                       16


<210> 8447
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8447
cgguaaguuc ugucc                                                        15


<210> 8448
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8448
cgguaaguuc uguc                                                         14


<210> 8449
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8449
cgguaaguuc ugu                                                          13


<210> 8450
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8450
cgguaaguuc ug                                                           12


<210> 8451
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8451
cgguaaguuc u                                                            11


<210> 8452
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8452
cgguaaguuc                                                              10


<210> 8453
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8453
cgguaaguu                                                                9


<210> 8454
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8454
cgguaagu                                                                 8


<210> 8455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8455
tcgguaaguu cuguccaagc                                                   20


<210> 8456
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8456
tcgguaaguu cuguccaag                                                    19


<210> 8457
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8457
tcgguaaguu cuguccaa                                                     18


<210> 8458
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8458
tcgguaaguu cugucca                                                      17


<210> 8459
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8459
tcgguaaguu cugucc                                                       16


<210> 8460
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8460
tcgguaaguu cuguc                                                        15


<210> 8461
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8461
tcgguaaguu cugu                                                         14


<210> 8462
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8462
tcgguaaguu cug                                                          13


<210> 8463
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8463
tcgguaaguu cu                                                           12


<210> 8464
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8464
tcgguaaguu c                                                            11


<210> 8465
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8465
tcgguaaguu                                                              10


<210> 8466
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8466
tcgguaagu                                                                9


<210> 8467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8467
gtcgguaagu ucuguccaag                                                   20


<210> 8468
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8468
gtcgguaagu ucuguccaa                                                    19


<210> 8469
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8469
gtcgguaagu ucugucca                                                     18


<210> 8470
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8470
gtcgguaagu ucugucc                                                      17


<210> 8471
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8471
gtcgguaagu ucuguc                                                       16


<210> 8472
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8472
gtcgguaagu ucugu                                                        15


<210> 8473
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8473
gtcgguaagu ucug                                                         14


<210> 8474
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8474
gtcgguaagu ucu                                                          13


<210> 8475
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8475
gtcgguaagu uc                                                           12


<210> 8476
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8476
gtcgguaagu u                                                            11


<210> 8477
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8477
gtcgguaagu                                                              10


<210> 8478
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8478
agucgguaag uucuguccaa                                                   20


<210> 8479
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8479
agucgguaag uucugucca                                                    19


<210> 8480
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8480
agucgguaag uucuguc                                                      17


<210> 8481
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8481
agucgguaag uucugu                                                       16


<210> 8482
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8482
agucgguaag uucug                                                        15


<210> 8483
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8483
agucgguaag uucu                                                         14


<210> 8484
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8484
agucgguaag uuc                                                          13


<210> 8485
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8485
agucgguaag uu                                                           12


<210> 8486
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8486
agucgguaag u                                                            11


<210> 8487
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8487
cagucgguaa guucugucca                                                   20


<210> 8488
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8488
cagucgguaa guucugucc                                                    19


<210> 8489
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8489
cagucgguaa guucuguc                                                     18


<210> 8490
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8490
cagucgguaa guucugu                                                      17


<210> 8491
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8491
cagucgguaa guucug                                                       16


<210> 8492
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8492
cagucgguaa guucu                                                        15


<210> 8493
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8493
cagucgguaa guuc                                                         14


<210> 8494
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8494
cagucgguaa guu                                                          13


<210> 8495
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8495
cagucgguaa gu                                                           12


<210> 8496
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8496
ccagucggua aguucugucc                                                   20


<210> 8497
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8497
ccagucggua aguucuguc                                                    19


<210> 8498
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8498
ccagucggua aguucugu                                                     18


<210> 8499
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8499
ccagucggua aguucug                                                      17


<210> 8500
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8500
ccagucggua aguucu                                                       16


<210> 8501
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8501
ccagucggua aguuc                                                        15


<210> 8502
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8502
ccagucggua aguu                                                         14


<210> 8503
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8503
ccagucggua agu                                                          13


<210> 8504
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8504
gccagucggu aaguucuguc                                                   20


<210> 8505
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8505
gccagucggu aaguucugu                                                    19


<210> 8506
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8506
gccagucggu aaguucug                                                     18


<210> 8507
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8507
gccagucggu aaguucu                                                      17


<210> 8508
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8508
gccagucggu aaguuc                                                       16


<210> 8509
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8509
gccagucggu aaguu                                                        15


<210> 8510
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8510
gccagucggu aagu                                                         14


<210> 8511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8511
tcaaggaaga uggcauuucu                                                   20


<210> 8512
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8512
tcaaggaaga uggcauuucu ag                                                22


<210> 8513
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8513
tcaaggaaga uggcau                                                       16


<210> 8514
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8514
gaagauggca uuucu                                                        15


<210> 8515
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8515
tcaaggaaga uggcauuucu a                                                 21


<210> 8516
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8516
tcaaggaaga uggcauuuc                                                    19


<210> 8517
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8517
tcaaggaaga uggcauuu                                                     18


<210> 8518
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8518
tcaaggaaga uggcauu                                                      17


<210> 8519
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8519
tcaaggaaga uggca                                                        15


<210> 8520
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8520
tcaaggaaga uggc                                                         14


<210> 8521
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8521
tcaaggaaga ugg                                                          13


<210> 8522
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8522
tcaaggaaga ug                                                           12


<210> 8523
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8523
tcaaggaaga u                                                            11


<210> 8524
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8524
tcaaggaaga                                                              10


<210> 8525
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8525
tcaaggaag                                                                9


<210> 8526
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8526
caaggaagau ggcauuucua g                                                 21


<210> 8527
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8527
caaggaagau ggcauuucua                                                   20


<210> 8528
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8528
caaggaagau ggcauuucu                                                    19


<210> 8529
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8529
caaggaagau ggcauuuc                                                     18


<210> 8530
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8530
caaggaagau ggcauuu                                                      17


<210> 8531
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8531
caaggaagau ggcauu                                                       16


<210> 8532
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8532
caaggaagau ggcau                                                        15


<210> 8533
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8533
caaggaagau ggca                                                         14


<210> 8534
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8534
caaggaagau ggc                                                          13


<210> 8535
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8535
caaggaagau gg                                                           12


<210> 8536
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8536
caaggaagau g                                                            11


<210> 8537
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8537
caaggaagau                                                              10


<210> 8538
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8538
caaggaaga                                                                9


<210> 8539
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8539
caaggaag                                                                 8


<210> 8540
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8540
aaggaagaug gcauuucuag                                                   20


<210> 8541
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8541
aaggaagaug gcauuucua                                                    19


<210> 8542
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8542
aaggaagaug gcauuucu                                                     18


<210> 8543
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8543
aaggaagaug gcauuuc                                                      17


<210> 8544
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8544
aaggaagaug gcauuu                                                       16


<210> 8545
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8545
aaggaagaug gcauu                                                        15


<210> 8546
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8546
aaggaagaug gcau                                                         14


<210> 8547
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8547
aaggaagaug gca                                                          13


<210> 8548
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8548
aaggaagaug gc                                                           12


<210> 8549
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8549
aaggaagaug g                                                            11


<210> 8550
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8550
aaggaagaug                                                              10


<210> 8551
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8551
aaggaagau                                                                9


<210> 8552
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8552
aaggaaga                                                                 8


<210> 8553
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8553
aggaagaugg cauuucuag                                                    19


<210> 8554
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8554
aggaagaugg cauuucua                                                     18


<210> 8555
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8555
aggaagaugg cauuucu                                                      17


<210> 8556
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8556
aggaagaugg cauuuc                                                       16


<210> 8557
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8557
aggaagaugg cauuu                                                        15


<210> 8558
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8558
aggaagaugg cauu                                                         14


<210> 8559
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8559
aggaagaugg cau                                                          13


<210> 8560
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8560
aggaagaugg ca                                                           12


<210> 8561
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8561
aggaagaugg                                                              10


<210> 8562
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8562
aggaagaug                                                                9


<210> 8563
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8563
aggaagau                                                                 8


<210> 8564
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8564
ggaagauggc auuucuag                                                     18


<210> 8565
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8565
ggaagauggc auuucua                                                      17


<210> 8566
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8566
ggaagauggc auuucu                                                       16


<210> 8567
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8567
ggaagauggc auuuc                                                        15


<210> 8568
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8568
ggaagauggc auuu                                                         14


<210> 8569
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8569
ggaagauggc auu                                                          13


<210> 8570
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8570
ggaagauggc au                                                           12


<210> 8571
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8571
ggaagauggc a                                                            11


<210> 8572
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8572
ggaagauggc                                                              10


<210> 8573
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8573
ggaagaug                                                                 8


<210> 8574
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8574
gaagauggca uuucuag                                                      17


<210> 8575
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8575
gaagauggca uuucua                                                       16


<210> 8576
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8576
gaagauggca uuuc                                                         14


<210> 8577
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8577
gaagauggca uuu                                                          13


<210> 8578
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8578
gaagauggca uu                                                           12


<210> 8579
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8579
gaagauggca u                                                            11


<210> 8580
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8580
gaagauggca                                                              10


<210> 8581
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8581
gaagauggc                                                                9


<210> 8582
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8582
gaagaugg                                                                 8


<210> 8583
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8583
aagauggcau uucuag                                                       16


<210> 8584
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8584
aagauggcau uucua                                                        15


<210> 8585
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8585
aagauggcau uucu                                                         14


<210> 8586
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8586
aagauggcau uuc                                                          13


<210> 8587
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8587
aagauggcau uu                                                           12


<210> 8588
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8588
aagauggcau u                                                            11


<210> 8589
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8589
aagauggcau                                                              10


<210> 8590
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8590
aagauggca                                                                9


<210> 8591
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8591
aagauggc                                                                 8


<210> 8592
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8592
agauggcauu ucuag                                                        15


<210> 8593
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8593
agauggcauu ucua                                                         14


<210> 8594
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8594
agauggcauu ucu                                                          13


<210> 8595
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8595
agauggcauu uc                                                           12


<210> 8596
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8596
agauggcauu u                                                            11


<210> 8597
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8597
agauggcauu                                                              10


<210> 8598
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8598
agauggcau                                                                9


<210> 8599
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8599
agauggca                                                                 8


<210> 8600
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8600
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 8601
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8601
ctccaacauc aaggaagaug gcauuucua                                         29


<210> 8602
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8602
ctccaacauc aaggaagaug gcauuucu                                          28


<210> 8603
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8603
ctccaacauc aaggaagaug gcauuuc                                           27


<210> 8604
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8604
ctccaacauc aaggaagaug gcauuu                                            26


<210> 8605
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8605
ctccaacauc aaggaagaug gcauu                                             25


<210> 8606
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8606
ctccaacauc aaggaagaug gcau                                              24


<210> 8607
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8607
ctccaacauc aaggaagaug gca                                               23


<210> 8608
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8608
ctccaacauc aaggaagaug gc                                                22


<210> 8609
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8609
ctccaacauc aaggaagaug g                                                 21


<210> 8610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8610
ctccaacauc aaggaagaug                                                   20


<210> 8611
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8611
ctccaacauc aaggaagau                                                    19


<210> 8612
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8612
ctccaacauc aaggaaga                                                     18


<210> 8613
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8613
ctccaacauc aaggaag                                                      17


<210> 8614
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8614
tccaacauca aggaagaugg cauuucuag                                         29


<210> 8615
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8615
tccaacauca aggaagaugg cauuucua                                          28


<210> 8616
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8616
tccaacauca aggaagaugg cauuucu                                           27


<210> 8617
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8617
tccaacauca aggaagaugg cauuuc                                            26


<210> 8618
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8618
tccaacauca aggaagaugg cauuu                                             25


<210> 8619
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8619
tccaacauca aggaagaugg cauu                                              24


<210> 8620
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8620
tccaacauca aggaagaugg cau                                               23


<210> 8621
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8621
tccaacauca aggaagaugg ca                                                22


<210> 8622
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8622
tccaacauca aggaagaugg c                                                 21


<210> 8623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8623
tccaacauca aggaagaugg                                                   20


<210> 8624
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8624
tccaacauca aggaagaug                                                    19


<210> 8625
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8625
tccaacauca aggaagau                                                     18


<210> 8626
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8626
tccaacauca aggaaga                                                      17


<210> 8627
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8627
tccaacauca aggaag                                                       16


<210> 8628
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8628
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 8629
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8629
ccaacaucaa ggaagauggc auuucua                                           27


<210> 8630
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8630
ccaacaucaa ggaagauggc auuucu                                            26


<210> 8631
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8631
ccaacaucaa ggaagauggc auuuc                                             25


<210> 8632
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8632
ccaacaucaa ggaagauggc auuu                                              24


<210> 8633
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8633
ccaacaucaa ggaagauggc auu                                               23


<210> 8634
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8634
ccaacaucaa ggaagauggc au                                                22


<210> 8635
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8635
ccaacaucaa ggaagauggc a                                                 21


<210> 8636
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8636
ccaacaucaa ggaagauggc                                                   20


<210> 8637
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8637
ccaacaucaa ggaagaugg                                                    19


<210> 8638
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8638
ccaacaucaa ggaagaug                                                     18


<210> 8639
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8639
ccaacaucaa ggaagau                                                      17


<210> 8640
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8640
ccaacaucaa ggaaga                                                       16


<210> 8641
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8641
ccaacaucaa ggaag                                                        15


<210> 8642
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8642
caacaucaag gaagauggca uuucuag                                           27


<210> 8643
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8643
caacaucaag gaagauggca uuucua                                            26


<210> 8644
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8644
caacaucaag gaagauggca uuucu                                             25


<210> 8645
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8645
caacaucaag gaagauggca uuuc                                              24


<210> 8646
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8646
caacaucaag gaagauggca uuu                                               23


<210> 8647
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8647
caacaucaag gaagauggca uu                                                22


<210> 8648
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8648
caacaucaag gaagauggca u                                                 21


<210> 8649
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8649
caacaucaag gaagauggca                                                   20


<210> 8650
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8650
caacaucaag gaagauggc                                                    19


<210> 8651
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8651
caacaucaag gaagaugg                                                     18


<210> 8652
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8652
caacaucaag gaagaug                                                      17


<210> 8653
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8653
caacaucaag gaagau                                                       16


<210> 8654
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8654
caacaucaag gaaga                                                        15


<210> 8655
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8655
caacaucaag gaag                                                         14


<210> 8656
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8656
aacaucaagg aagauggcau uucuag                                            26


<210> 8657
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8657
aacaucaagg aagauggcau uucua                                             25


<210> 8658
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8658
aacaucaagg aagauggcau uucu                                              24


<210> 8659
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8659
aacaucaagg aagauggcau uuc                                               23


<210> 8660
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8660
aacaucaagg aagauggcau uu                                                22


<210> 8661
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8661
aacaucaagg aagauggcau u                                                 21


<210> 8662
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8662
aacaucaagg aagauggcau                                                   20


<210> 8663
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8663
aacaucaagg aagauggca                                                    19


<210> 8664
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8664
aacaucaagg aagauggc                                                     18


<210> 8665
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8665
aacaucaagg aagaugg                                                      17


<210> 8666
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8666
aacaucaagg aagaug                                                       16


<210> 8667
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8667
aacaucaagg aagau                                                        15


<210> 8668
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8668
aacaucaagg aaga                                                         14


<210> 8669
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8669
aacaucaagg aag                                                          13


<210> 8670
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8670
acaucaagga agauggcauu ucuag                                             25


<210> 8671
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8671
acaucaagga agauggcauu ucua                                              24


<210> 8672
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8672
acaucaagga agauggcauu ucu                                               23


<210> 8673
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8673
acaucaagga agauggcauu uc                                                22


<210> 8674
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8674
acaucaagga agauggcauu u                                                 21


<210> 8675
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8675
acaucaagga agauggcauu                                                   20


<210> 8676
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8676
acaucaagga agauggcau                                                    19


<210> 8677
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8677
acaucaagga agauggca                                                     18


<210> 8678
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8678
acaucaagga agauggc                                                      17


<210> 8679
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8679
acaucaagga agaugg                                                       16


<210> 8680
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8680
acaucaagga agaug                                                        15


<210> 8681
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8681
acaucaagga agau                                                         14


<210> 8682
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8682
acaucaagga aga                                                          13


<210> 8683
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8683
acaucaagga ag                                                           12


<210> 8684
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8684
caucaaggaa gauggcauuu cuag                                              24


<210> 8685
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8685
caucaaggaa gauggcauuu cua                                               23


<210> 8686
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8686
caucaaggaa gauggcauuu cu                                                22


<210> 8687
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8687
caucaaggaa gauggcauuu c                                                 21


<210> 8688
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8688
caucaaggaa gauggcauuu                                                   20


<210> 8689
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8689
caucaaggaa gauggcauu                                                    19


<210> 8690
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8690
caucaaggaa gauggcau                                                     18


<210> 8691
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8691
caucaaggaa gauggca                                                      17


<210> 8692
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8692
caucaaggaa gauggc                                                       16


<210> 8693
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8693
caucaaggaa gaugg                                                        15


<210> 8694
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8694
caucaaggaa gaug                                                         14


<210> 8695
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8695
caucaaggaa gau                                                          13


<210> 8696
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8696
caucaaggaa ga                                                           12


<210> 8697
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8697
caucaaggaa g                                                            11


<210> 8698
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8698
atcaaggaag auggcauuuc uag                                               23


<210> 8699
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8699
atcaaggaag auggcauuuc ua                                                22


<210> 8700
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8700
atcaaggaag auggcauuuc u                                                 21


<210> 8701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8701
atcaaggaag auggcauuuc                                                   20


<210> 8702
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8702
atcaaggaag auggcauuu                                                    19


<210> 8703
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8703
atcaaggaag auggcauu                                                     18


<210> 8704
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8704
atcaaggaag auggcau                                                      17


<210> 8705
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8705
atcaaggaag auggca                                                       16


<210> 8706
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8706
atcaaggaag auggc                                                        15


<210> 8707
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8707
atcaaggaag augg                                                         14


<210> 8708
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8708
atcaaggaag aug                                                          13


<210> 8709
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8709
atcaaggaag au                                                           12


<210> 8710
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8710
atcaaggaag a                                                            11


<210> 8711
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8711
atcaaggaag                                                              10


<210> 8712
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8712
ccagagcagg uaccuccaac auc                                               23


<210> 8713
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8713
ccagagcagg uaccucca                                                     18


<210> 8714
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8714
ccucugugau uuuauaacuu gau                                               23


<210> 8715
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8715
tcacccacca ucacccu                                                      17


<210> 8716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8716
tgauauccuc aaggucaccc                                                   20


<210> 8717
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8717
ctgcuugaug aucaucucgu ug                                                22


<210> 8718
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8718
ctgcuugaug aucaucuc                                                     18


<210> 8719
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8719
gtuuccuuag uaaccacag                                                    19


<210> 8720
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 8720
gtuuccuuag uaaccac                                                      17


<210> 8721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8721
tcaaggaaga uggcauuucu                                                   20


<210> 8722
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8722
tcaaggaaga uggcauuucu ag                                                22


<210> 8723
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8723
gguaaguucu guccaagc                                                     18


<210> 8724
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8724
gtaaguucug uccaagcc                                                     18


<210> 8725
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8725
agucgguaag uucugucc                                                     18


<210> 8726
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8726
ctguccaagc ccgguuga                                                     18


<210> 8727
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8727
taaguucugu ccaag                                                        15


<210> 8728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8728
ttcuguccaa gcccgguuga                                                   20


<210> 8729
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8729
ttcuguccaa gcccgguug                                                    19


<210> 8730
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8730
ttcuguccaa gcccgguu                                                     18


<210> 8731
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8731
ttcuguccaa gcccggu                                                      17


<210> 8732
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8732
ttcuguccaa gcccgg                                                       16


<210> 8733
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8733
ttcuguccaa gcccg                                                        15


<210> 8734
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8734
ttcuguccaa gccc                                                         14


<210> 8735
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8735
ttcuguccaa gcc                                                          13


<210> 8736
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8736
ttcuguccaa gc                                                           12


<210> 8737
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8737
ttcuguccaa g                                                            11


<210> 8738
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8738
ttcuguccaa                                                              10


<210> 8739
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8739
ttcugucca                                                                9


<210> 8740
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8740
ttcugucc                                                                 8


<210> 8741
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8741
tcuguccaag cccgguuga                                                    19


<210> 8742
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8742
tcuguccaag cccgguug                                                     18


<210> 8743
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8743
tcuguccaag cccgguu                                                      17


<210> 8744
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8744
tcuguccaag cccggu                                                       16


<210> 8745
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8745
tcuguccaag cccgg                                                        15


<210> 8746
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8746
tcuguccaag cccg                                                         14


<210> 8747
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8747
tcuguccaag ccc                                                          13


<210> 8748
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8748
tcuguccaag cc                                                           12


<210> 8749
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8749
tcuguccaag c                                                            11


<210> 8750
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8750
tcuguccaag                                                              10


<210> 8751
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8751
tcuguccaa                                                                9


<210> 8752
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8752
tcugucca                                                                 8


<210> 8753
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8753
ctguccaagc ccgguug                                                      17


<210> 8754
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8754
ctguccaagc ccgguu                                                       16


<210> 8755
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8755
ctguccaagc ccggu                                                        15


<210> 8756
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8756
ctguccaagc ccgg                                                         14


<210> 8757
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8757
ctguccaagc ccg                                                          13


<210> 8758
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8758
ctguccaagc cc                                                           12


<210> 8759
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8759
ctguccaagc c                                                            11


<210> 8760
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8760
ctguccaagc                                                              10


<210> 8761
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8761
ctguccaag                                                                9


<210> 8762
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8762
ctguccaa                                                                 8


<210> 8763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8763
gtucugucca agcccgguug                                                   20


<210> 8764
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8764
gtucugucca agcccgguu                                                    19


<210> 8765
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8765
gtucugucca agcccggu                                                     18


<210> 8766
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8766
gtucugucca agcccgg                                                      17


<210> 8767
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8767
gtucugucca agcccg                                                       16


<210> 8768
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8768
gtucugucca agccc                                                        15


<210> 8769
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8769
gtucugucca agcc                                                         14


<210> 8770
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8770
gtucugucca agc                                                          13


<210> 8771
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8771
gtucugucca ag                                                           12


<210> 8772
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8772
gtucugucca a                                                            11


<210> 8773
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8773
gtucugucca                                                              10


<210> 8774
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8774
gtucugucc                                                                9


<210> 8775
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8775
gtucuguc                                                                 8


<210> 8776
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8776
aguucugucc aagcccgguu                                                   20


<210> 8777
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8777
aguucugucc aagcccggu                                                    19


<210> 8778
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8778
aguucugucc aagcccgg                                                     18


<210> 8779
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8779
aguucugucc aagcccg                                                      17


<210> 8780
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8780
aguucugucc aagccc                                                       16


<210> 8781
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8781
aguucugucc aagcc                                                        15


<210> 8782
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8782
aguucugucc aagc                                                         14


<210> 8783
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8783
aguucugucc aag                                                          13


<210> 8784
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8784
aguucugucc aa                                                           12


<210> 8785
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8785
aguucugucc a                                                            11


<210> 8786
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8786
aguucugucc                                                              10


<210> 8787
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8787
aguucuguc                                                                9


<210> 8788
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8788
aguucugu                                                                 8


<210> 8789
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8789
aaguucuguc caagcccggu                                                   20


<210> 8790
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8790
aaguucuguc caagcccgg                                                    19


<210> 8791
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8791
aaguucuguc caagcccg                                                     18


<210> 8792
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8792
aaguucuguc caagccc                                                      17


<210> 8793
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8793
aaguucuguc caagcc                                                       16


<210> 8794
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8794
aaguucuguc caagc                                                        15


<210> 8795
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8795
aaguucuguc caag                                                         14


<210> 8796
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8796
aaguucuguc caa                                                          13


<210> 8797
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8797
aaguucuguc ca                                                           12


<210> 8798
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8798
aaguucuguc c                                                            11


<210> 8799
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8799
aaguucuguc                                                              10


<210> 8800
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8800
aaguucugu                                                                9


<210> 8801
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8801
aaguucug                                                                 8


<210> 8802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8802
taaguucugu ccaagcccgg                                                   20


<210> 8803
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8803
taaguucugu ccaagcccg                                                    19


<210> 8804
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8804
taaguucugu ccaagccc                                                     18


<210> 8805
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8805
taaguucugu ccaagcc                                                      17


<210> 8806
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8806
taaguucugu ccaagc                                                       16


<210> 8807
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8807
taaguucugu ccaa                                                         14


<210> 8808
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8808
taaguucugu cca                                                          13


<210> 8809
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8809
taaguucugu cc                                                           12


<210> 8810
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8810
taaguucugu c                                                            11


<210> 8811
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8811
taaguucugu                                                              10


<210> 8812
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8812
taaguucug                                                                9


<210> 8813
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8813
taaguucu                                                                 8


<210> 8814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8814
gtaaguucug uccaagcccg                                                   20


<210> 8815
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8815
gtaaguucug uccaagccc                                                    19


<210> 8816
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8816
gtaaguucug uccaagc                                                      17


<210> 8817
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8817
gtaaguucug uccaag                                                       16


<210> 8818
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8818
gtaaguucug uccaa                                                        15


<210> 8819
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8819
gtaaguucug ucca                                                         14


<210> 8820
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8820
gtaaguucug ucc                                                          13


<210> 8821
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8821
gtaaguucug uc                                                           12


<210> 8822
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8822
gtaaguucug u                                                            11


<210> 8823
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8823
gtaaguucug                                                              10


<210> 8824
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8824
gtaaguucu                                                                9


<210> 8825
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8825
gtaaguuc                                                                 8


<210> 8826
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8826
gguaaguucu guccaagccc                                                   20


<210> 8827
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8827
gguaaguucu guccaagcc                                                    19


<210> 8828
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8828
gguaaguucu guccaag                                                      17


<210> 8829
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8829
gguaaguucu guccaa                                                       16


<210> 8830
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8830
gguaaguucu gucca                                                        15


<210> 8831
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8831
gguaaguucu gucc                                                         14


<210> 8832
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8832
gguaaguucu guc                                                          13


<210> 8833
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8833
gguaaguucu gu                                                           12


<210> 8834
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8834
gguaaguucu g                                                            11


<210> 8835
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8835
gguaaguucu                                                              10


<210> 8836
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8836
gguaaguuc                                                                9


<210> 8837
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8837
gguaaguu                                                                 8


<210> 8838
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8838
cgguaaguuc uguccaagcc                                                   20


<210> 8839
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8839
cgguaaguuc uguccaagc                                                    19


<210> 8840
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8840
cgguaaguuc uguccaag                                                     18


<210> 8841
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8841
cgguaaguuc uguccaa                                                      17


<210> 8842
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8842
cgguaaguuc ugucca                                                       16


<210> 8843
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8843
cgguaaguuc ugucc                                                        15


<210> 8844
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8844
cgguaaguuc uguc                                                         14


<210> 8845
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8845
cgguaaguuc ugu                                                          13


<210> 8846
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8846
cgguaaguuc ug                                                           12


<210> 8847
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8847
cgguaaguuc u                                                            11


<210> 8848
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8848
cgguaaguuc                                                              10


<210> 8849
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8849
cgguaaguu                                                                9


<210> 8850
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8850
cgguaagu                                                                 8


<210> 8851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8851
tcgguaaguu cuguccaagc                                                   20


<210> 8852
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8852
tcgguaaguu cuguccaag                                                    19


<210> 8853
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8853
tcgguaaguu cuguccaa                                                     18


<210> 8854
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8854
tcgguaaguu cugucca                                                      17


<210> 8855
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8855
tcgguaaguu cugucc                                                       16


<210> 8856
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8856
tcgguaaguu cuguc                                                        15


<210> 8857
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8857
tcgguaaguu cugu                                                         14


<210> 8858
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8858
tcgguaaguu cug                                                          13


<210> 8859
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8859
tcgguaaguu cu                                                           12


<210> 8860
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8860
tcgguaaguu c                                                            11


<210> 8861
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8861
tcgguaaguu                                                              10


<210> 8862
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8862
tcgguaagu                                                                9


<210> 8863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8863
gtcgguaagu ucuguccaag                                                   20


<210> 8864
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8864
gtcgguaagu ucuguccaa                                                    19


<210> 8865
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8865
gtcgguaagu ucugucca                                                     18


<210> 8866
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8866
gtcgguaagu ucugucc                                                      17


<210> 8867
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8867
gtcgguaagu ucuguc                                                       16


<210> 8868
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8868
gtcgguaagu ucugu                                                        15


<210> 8869
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8869
gtcgguaagu ucug                                                         14


<210> 8870
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8870
gtcgguaagu ucu                                                          13


<210> 8871
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8871
gtcgguaagu uc                                                           12


<210> 8872
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8872
gtcgguaagu u                                                            11


<210> 8873
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8873
gtcgguaagu                                                              10


<210> 8874
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8874
agucgguaag uucuguccaa                                                   20


<210> 8875
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8875
agucgguaag uucugucca                                                    19


<210> 8876
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8876
agucgguaag uucuguc                                                      17


<210> 8877
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8877
agucgguaag uucugu                                                       16


<210> 8878
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8878
agucgguaag uucug                                                        15


<210> 8879
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8879
agucgguaag uucu                                                         14


<210> 8880
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8880
agucgguaag uuc                                                          13


<210> 8881
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8881
agucgguaag uu                                                           12


<210> 8882
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8882
agucgguaag u                                                            11


<210> 8883
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8883
cagucgguaa guucugucca                                                   20


<210> 8884
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8884
cagucgguaa guucugucc                                                    19


<210> 8885
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8885
cagucgguaa guucuguc                                                     18


<210> 8886
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8886
cagucgguaa guucugu                                                      17


<210> 8887
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8887
cagucgguaa guucug                                                       16


<210> 8888
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8888
cagucgguaa guucu                                                        15


<210> 8889
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8889
cagucgguaa guuc                                                         14


<210> 8890
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8890
cagucgguaa guu                                                          13


<210> 8891
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8891
cagucgguaa gu                                                           12


<210> 8892
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8892
ccagucggua aguucugucc                                                   20


<210> 8893
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8893
ccagucggua aguucuguc                                                    19


<210> 8894
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8894
ccagucggua aguucugu                                                     18


<210> 8895
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8895
ccagucggua aguucug                                                      17


<210> 8896
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8896
ccagucggua aguucu                                                       16


<210> 8897
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8897
ccagucggua aguuc                                                        15


<210> 8898
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8898
ccagucggua aguu                                                         14


<210> 8899
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8899
ccagucggua agu                                                          13


<210> 8900
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8900
gccagucggu aaguucuguc                                                   20


<210> 8901
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8901
gccagucggu aaguucugu                                                    19


<210> 8902
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8902
gccagucggu aaguucug                                                     18


<210> 8903
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8903
gccagucggu aaguucu                                                      17


<210> 8904
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8904
gccagucggu aaguuc                                                       16


<210> 8905
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8905
gccagucggu aaguu                                                        15


<210> 8906
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8906
gccagucggu aagu                                                         14


<210> 8907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8907
tcaaggaaga uggcauuucu                                                   20


<210> 8908
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8908
tcaaggaaga uggcauuucu ag                                                22


<210> 8909
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8909
tcaaggaaga uggcau                                                       16


<210> 8910
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8910
gaagauggca uuucu                                                        15


<210> 8911
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8911
tcaaggaaga uggcauuucu a                                                 21


<210> 8912
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8912
tcaaggaaga uggcauuuc                                                    19


<210> 8913
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8913
tcaaggaaga uggcauuu                                                     18


<210> 8914
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8914
tcaaggaaga uggcauu                                                      17


<210> 8915
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8915
tcaaggaaga uggca                                                        15


<210> 8916
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8916
tcaaggaaga uggc                                                         14


<210> 8917
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8917
tcaaggaaga ugg                                                          13


<210> 8918
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8918
tcaaggaaga ug                                                           12


<210> 8919
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8919
tcaaggaaga u                                                            11


<210> 8920
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8920
tcaaggaaga                                                              10


<210> 8921
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8921
tcaaggaag                                                                9


<210> 8922
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8922
caaggaagau ggcauuucua g                                                 21


<210> 8923
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8923
caaggaagau ggcauuucua                                                   20


<210> 8924
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8924
caaggaagau ggcauuucu                                                    19


<210> 8925
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8925
caaggaagau ggcauuuc                                                     18


<210> 8926
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8926
caaggaagau ggcauuu                                                      17


<210> 8927
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8927
caaggaagau ggcauu                                                       16


<210> 8928
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8928
caaggaagau ggcau                                                        15


<210> 8929
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8929
caaggaagau ggca                                                         14


<210> 8930
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8930
caaggaagau ggc                                                          13


<210> 8931
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8931
caaggaagau gg                                                           12


<210> 8932
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8932
caaggaagau g                                                            11


<210> 8933
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8933
caaggaagau                                                              10


<210> 8934
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8934
caaggaaga                                                                9


<210> 8935
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8935
caaggaag                                                                 8


<210> 8936
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8936
aaggaagaug gcauuucuag                                                   20


<210> 8937
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8937
aaggaagaug gcauuucua                                                    19


<210> 8938
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8938
aaggaagaug gcauuucu                                                     18


<210> 8939
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8939
aaggaagaug gcauuuc                                                      17


<210> 8940
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8940
aaggaagaug gcauuu                                                       16


<210> 8941
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8941
aaggaagaug gcauu                                                        15


<210> 8942
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8942
aaggaagaug gcau                                                         14


<210> 8943
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8943
aaggaagaug gca                                                          13


<210> 8944
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8944
aaggaagaug gc                                                           12


<210> 8945
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8945
aaggaagaug g                                                            11


<210> 8946
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8946
aaggaagaug                                                              10


<210> 8947
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8947
aaggaagau                                                                9


<210> 8948
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8948
aaggaaga                                                                 8


<210> 8949
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8949
aggaagaugg cauuucuag                                                    19


<210> 8950
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8950
aggaagaugg cauuucua                                                     18


<210> 8951
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8951
aggaagaugg cauuucu                                                      17


<210> 8952
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8952
aggaagaugg cauuuc                                                       16


<210> 8953
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8953
aggaagaugg cauuu                                                        15


<210> 8954
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8954
aggaagaugg cauu                                                         14


<210> 8955
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8955
aggaagaugg cau                                                          13


<210> 8956
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8956
aggaagaugg ca                                                           12


<210> 8957
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8957
aggaagaugg                                                              10


<210> 8958
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8958
aggaagaug                                                                9


<210> 8959
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8959
aggaagau                                                                 8


<210> 8960
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8960
ggaagauggc auuucuag                                                     18


<210> 8961
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8961
ggaagauggc auuucua                                                      17


<210> 8962
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8962
ggaagauggc auuucu                                                       16


<210> 8963
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8963
ggaagauggc auuuc                                                        15


<210> 8964
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8964
ggaagauggc auuu                                                         14


<210> 8965
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8965
ggaagauggc auu                                                          13


<210> 8966
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8966
ggaagauggc au                                                           12


<210> 8967
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8967
ggaagauggc a                                                            11


<210> 8968
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8968
ggaagauggc                                                              10


<210> 8969
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8969
ggaagaug                                                                 8


<210> 8970
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8970
gaagauggca uuucuag                                                      17


<210> 8971
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8971
gaagauggca uuucua                                                       16


<210> 8972
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8972
gaagauggca uuuc                                                         14


<210> 8973
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8973
gaagauggca uuu                                                          13


<210> 8974
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8974
gaagauggca uu                                                           12


<210> 8975
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8975
gaagauggca u                                                            11


<210> 8976
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8976
gaagauggca                                                              10


<210> 8977
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8977
gaagauggc                                                                9


<210> 8978
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8978
gaagaugg                                                                 8


<210> 8979
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8979
aagauggcau uucuag                                                       16


<210> 8980
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8980
aagauggcau uucua                                                        15


<210> 8981
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8981
aagauggcau uucu                                                         14


<210> 8982
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8982
aagauggcau uuc                                                          13


<210> 8983
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8983
aagauggcau uu                                                           12


<210> 8984
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8984
aagauggcau u                                                            11


<210> 8985
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8985
aagauggcau                                                              10


<210> 8986
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8986
aagauggca                                                                9


<210> 8987
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8987
aagauggc                                                                 8


<210> 8988
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8988
agauggcauu ucuag                                                        15


<210> 8989
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8989
agauggcauu ucua                                                         14


<210> 8990
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8990
agauggcauu ucu                                                          13


<210> 8991
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8991
agauggcauu uc                                                           12


<210> 8992
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8992
agauggcauu u                                                            11


<210> 8993
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8993
agauggcauu                                                              10


<210> 8994
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8994
agauggcau                                                                9


<210> 8995
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8995
agauggca                                                                 8


<210> 8996
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8996
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 8997
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8997
ctccaacauc aaggaagaug gcauuucua                                         29


<210> 8998
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8998
ctccaacauc aaggaagaug gcauuucu                                          28


<210> 8999
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 8999
ctccaacauc aaggaagaug gcauuuc                                           27


<210> 9000
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9000
ctccaacauc aaggaagaug gcauuu                                            26


<210> 9001
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9001
ctccaacauc aaggaagaug gcauu                                             25


<210> 9002
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9002
ctccaacauc aaggaagaug gcau                                              24


<210> 9003
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9003
ctccaacauc aaggaagaug gca                                               23


<210> 9004
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9004
ctccaacauc aaggaagaug gc                                                22


<210> 9005
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9005
ctccaacauc aaggaagaug g                                                 21


<210> 9006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9006
ctccaacauc aaggaagaug                                                   20


<210> 9007
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9007
ctccaacauc aaggaagau                                                    19


<210> 9008
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9008
ctccaacauc aaggaaga                                                     18


<210> 9009
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9009
ctccaacauc aaggaag                                                      17


<210> 9010
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9010
tccaacauca aggaagaugg cauuucuag                                         29


<210> 9011
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9011
tccaacauca aggaagaugg cauuucua                                          28


<210> 9012
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9012
tccaacauca aggaagaugg cauuucu                                           27


<210> 9013
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9013
tccaacauca aggaagaugg cauuuc                                            26


<210> 9014
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9014
tccaacauca aggaagaugg cauuu                                             25


<210> 9015
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9015
tccaacauca aggaagaugg cauu                                              24


<210> 9016
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9016
tccaacauca aggaagaugg cau                                               23


<210> 9017
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9017
tccaacauca aggaagaugg ca                                                22


<210> 9018
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9018
tccaacauca aggaagaugg c                                                 21


<210> 9019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9019
tccaacauca aggaagaugg                                                   20


<210> 9020
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9020
tccaacauca aggaagaug                                                    19


<210> 9021
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9021
tccaacauca aggaagau                                                     18


<210> 9022
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9022
tccaacauca aggaaga                                                      17


<210> 9023
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9023
tccaacauca aggaag                                                       16


<210> 9024
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9024
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 9025
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9025
ccaacaucaa ggaagauggc auuucua                                           27


<210> 9026
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9026
ccaacaucaa ggaagauggc auuucu                                            26


<210> 9027
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9027
ccaacaucaa ggaagauggc auuuc                                             25


<210> 9028
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9028
ccaacaucaa ggaagauggc auuu                                              24


<210> 9029
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9029
ccaacaucaa ggaagauggc auu                                               23


<210> 9030
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9030
ccaacaucaa ggaagauggc au                                                22


<210> 9031
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9031
ccaacaucaa ggaagauggc a                                                 21


<210> 9032
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9032
ccaacaucaa ggaagauggc                                                   20


<210> 9033
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9033
ccaacaucaa ggaagaugg                                                    19


<210> 9034
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9034
ccaacaucaa ggaagaug                                                     18


<210> 9035
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9035
ccaacaucaa ggaagau                                                      17


<210> 9036
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9036
ccaacaucaa ggaaga                                                       16


<210> 9037
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9037
ccaacaucaa ggaag                                                        15


<210> 9038
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9038
caacaucaag gaagauggca uuucuag                                           27


<210> 9039
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9039
caacaucaag gaagauggca uuucua                                            26


<210> 9040
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9040
caacaucaag gaagauggca uuucu                                             25


<210> 9041
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9041
caacaucaag gaagauggca uuuc                                              24


<210> 9042
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9042
caacaucaag gaagauggca uuu                                               23


<210> 9043
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9043
caacaucaag gaagauggca uu                                                22


<210> 9044
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9044
caacaucaag gaagauggca u                                                 21


<210> 9045
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9045
caacaucaag gaagauggca                                                   20


<210> 9046
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9046
caacaucaag gaagauggc                                                    19


<210> 9047
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9047
caacaucaag gaagaugg                                                     18


<210> 9048
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9048
caacaucaag gaagaug                                                      17


<210> 9049
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9049
caacaucaag gaagau                                                       16


<210> 9050
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9050
caacaucaag gaaga                                                        15


<210> 9051
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9051
caacaucaag gaag                                                         14


<210> 9052
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9052
aacaucaagg aagauggcau uucuag                                            26


<210> 9053
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9053
aacaucaagg aagauggcau uucua                                             25


<210> 9054
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9054
aacaucaagg aagauggcau uucu                                              24


<210> 9055
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9055
aacaucaagg aagauggcau uuc                                               23


<210> 9056
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9056
aacaucaagg aagauggcau uu                                                22


<210> 9057
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9057
aacaucaagg aagauggcau u                                                 21


<210> 9058
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9058
aacaucaagg aagauggcau                                                   20


<210> 9059
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9059
aacaucaagg aagauggca                                                    19


<210> 9060
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9060
aacaucaagg aagauggc                                                     18


<210> 9061
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9061
aacaucaagg aagaugg                                                      17


<210> 9062
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9062
aacaucaagg aagaug                                                       16


<210> 9063
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9063
aacaucaagg aagau                                                        15


<210> 9064
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9064
aacaucaagg aaga                                                         14


<210> 9065
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9065
aacaucaagg aag                                                          13


<210> 9066
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9066
acaucaagga agauggcauu ucuag                                             25


<210> 9067
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9067
acaucaagga agauggcauu ucua                                              24


<210> 9068
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9068
acaucaagga agauggcauu ucu                                               23


<210> 9069
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9069
acaucaagga agauggcauu uc                                                22


<210> 9070
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9070
acaucaagga agauggcauu u                                                 21


<210> 9071
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9071
acaucaagga agauggcauu                                                   20


<210> 9072
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9072
acaucaagga agauggcau                                                    19


<210> 9073
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9073
acaucaagga agauggca                                                     18


<210> 9074
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9074
acaucaagga agauggc                                                      17


<210> 9075
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9075
acaucaagga agaugg                                                       16


<210> 9076
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9076
acaucaagga agaug                                                        15


<210> 9077
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9077
acaucaagga agau                                                         14


<210> 9078
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9078
acaucaagga aga                                                          13


<210> 9079
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9079
acaucaagga ag                                                           12


<210> 9080
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9080
caucaaggaa gauggcauuu cuag                                              24


<210> 9081
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9081
caucaaggaa gauggcauuu cua                                               23


<210> 9082
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9082
caucaaggaa gauggcauuu cu                                                22


<210> 9083
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9083
caucaaggaa gauggcauuu c                                                 21


<210> 9084
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9084
caucaaggaa gauggcauuu                                                   20


<210> 9085
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9085
caucaaggaa gauggcauu                                                    19


<210> 9086
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9086
caucaaggaa gauggcau                                                     18


<210> 9087
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9087
caucaaggaa gauggca                                                      17


<210> 9088
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9088
caucaaggaa gauggc                                                       16


<210> 9089
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9089
caucaaggaa gaugg                                                        15


<210> 9090
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9090
caucaaggaa gaug                                                         14


<210> 9091
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9091
caucaaggaa gau                                                          13


<210> 9092
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9092
caucaaggaa ga                                                           12


<210> 9093
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9093
caucaaggaa g                                                            11


<210> 9094
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9094
atcaaggaag auggcauuuc uag                                               23


<210> 9095
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9095
atcaaggaag auggcauuuc ua                                                22


<210> 9096
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9096
atcaaggaag auggcauuuc u                                                 21


<210> 9097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9097
atcaaggaag auggcauuuc                                                   20


<210> 9098
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9098
atcaaggaag auggcauuu                                                    19


<210> 9099
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9099
atcaaggaag auggcauu                                                     18


<210> 9100
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9100
atcaaggaag auggcau                                                      17


<210> 9101
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9101
atcaaggaag auggca                                                       16


<210> 9102
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9102
atcaaggaag auggc                                                        15


<210> 9103
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9103
atcaaggaag augg                                                         14


<210> 9104
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9104
atcaaggaag aug                                                          13


<210> 9105
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9105
atcaaggaag au                                                           12


<210> 9106
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9106
atcaaggaag a                                                            11


<210> 9107
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9107
atcaaggaag                                                              10


<210> 9108
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9108
ccagagcagg uaccuccaac auc                                               23


<210> 9109
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9109
ccagagcagg uaccucca                                                     18


<210> 9110
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9110
ccucugugau uuuauaacuu gau                                               23


<210> 9111
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9111
tcacccacca ucacccu                                                      17


<210> 9112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9112
tgauauccuc aaggucaccc                                                   20


<210> 9113
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9113
ctgcuugaug aucaucucgu ug                                                22


<210> 9114
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9114
ctgcuugaug aucaucuc                                                     18


<210> 9115
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9115
gtuuccuuag uaaccacag                                                    19


<210> 9116
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9116
gtuuccuuag uaaccac                                                      17


<210> 9117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9117
tcaaggaaga uggcauuucu                                                   20


<210> 9118
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9118
tcaaggaaga uggcauuucu ag                                                22


<210> 9119
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9119
gguaaguucu guccaagc                                                     18


<210> 9120
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9120
gtaaguucug uccaagcc                                                     18


<210> 9121
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9121
agucgguaag uucugucc                                                     18


<210> 9122
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9122
ctguccaagc ccgguuga                                                     18


<210> 9123
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9123
taaguucugu ccaag                                                        15


<210> 9124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9124
ttcuguccaa gcccgguuga                                                   20


<210> 9125
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9125
ttcuguccaa gcccgguug                                                    19


<210> 9126
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9126
ttcuguccaa gcccgguu                                                     18


<210> 9127
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9127
ttcuguccaa gcccggu                                                      17


<210> 9128
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9128
ttcuguccaa gcccgg                                                       16


<210> 9129
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9129
ttcuguccaa gcccg                                                        15


<210> 9130
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9130
ttcuguccaa gccc                                                         14


<210> 9131
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9131
ttcuguccaa gcc                                                          13


<210> 9132
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9132
ttcuguccaa gc                                                           12


<210> 9133
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9133
ttcuguccaa g                                                            11


<210> 9134
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9134
ttcuguccaa                                                              10


<210> 9135
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9135
ttcugucca                                                                9


<210> 9136
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9136
ttcugucc                                                                 8


<210> 9137
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9137
tcuguccaag cccgguuga                                                    19


<210> 9138
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9138
tcuguccaag cccgguug                                                     18


<210> 9139
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9139
tcuguccaag cccgguu                                                      17


<210> 9140
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9140
tcuguccaag cccggu                                                       16


<210> 9141
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9141
tcuguccaag cccgg                                                        15


<210> 9142
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9142
tcuguccaag cccg                                                         14


<210> 9143
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9143
tcuguccaag ccc                                                          13


<210> 9144
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9144
tcuguccaag cc                                                           12


<210> 9145
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9145
tcuguccaag c                                                            11


<210> 9146
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9146
tcuguccaag                                                              10


<210> 9147
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9147
tcuguccaa                                                                9


<210> 9148
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9148
tcugucca                                                                 8


<210> 9149
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9149
ctguccaagc ccgguug                                                      17


<210> 9150
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9150
ctguccaagc ccgguu                                                       16


<210> 9151
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9151
ctguccaagc ccggu                                                        15


<210> 9152
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9152
ctguccaagc ccgg                                                         14


<210> 9153
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9153
ctguccaagc ccg                                                          13


<210> 9154
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9154
ctguccaagc cc                                                           12


<210> 9155
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9155
ctguccaagc c                                                            11


<210> 9156
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9156
ctguccaagc                                                              10


<210> 9157
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9157
ctguccaag                                                                9


<210> 9158
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9158
ctguccaa                                                                 8


<210> 9159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9159
gtucugucca agcccgguug                                                   20


<210> 9160
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9160
gtucugucca agcccgguu                                                    19


<210> 9161
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9161
gtucugucca agcccggu                                                     18


<210> 9162
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9162
gtucugucca agcccgg                                                      17


<210> 9163
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9163
gtucugucca agcccg                                                       16


<210> 9164
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9164
gtucugucca agccc                                                        15


<210> 9165
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9165
gtucugucca agcc                                                         14


<210> 9166
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9166
gtucugucca agc                                                          13


<210> 9167
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9167
gtucugucca ag                                                           12


<210> 9168
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9168
gtucugucca a                                                            11


<210> 9169
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9169
gtucugucca                                                              10


<210> 9170
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9170
gtucugucc                                                                9


<210> 9171
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9171
gtucuguc                                                                 8


<210> 9172
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9172
aguucugucc aagcccgguu                                                   20


<210> 9173
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9173
aguucugucc aagcccggu                                                    19


<210> 9174
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9174
aguucugucc aagcccgg                                                     18


<210> 9175
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9175
aguucugucc aagcccg                                                      17


<210> 9176
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9176
aguucugucc aagccc                                                       16


<210> 9177
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9177
aguucugucc aagcc                                                        15


<210> 9178
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9178
aguucugucc aagc                                                         14


<210> 9179
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9179
aguucugucc aag                                                          13


<210> 9180
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9180
aguucugucc aa                                                           12


<210> 9181
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9181
aguucugucc a                                                            11


<210> 9182
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9182
aguucugucc                                                              10


<210> 9183
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9183
aguucuguc                                                                9


<210> 9184
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9184
aguucugu                                                                 8


<210> 9185
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9185
aaguucuguc caagcccggu                                                   20


<210> 9186
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9186
aaguucuguc caagcccgg                                                    19


<210> 9187
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9187
aaguucuguc caagcccg                                                     18


<210> 9188
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9188
aaguucuguc caagccc                                                      17


<210> 9189
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9189
aaguucuguc caagcc                                                       16


<210> 9190
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9190
aaguucuguc caagc                                                        15


<210> 9191
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9191
aaguucuguc caag                                                         14


<210> 9192
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9192
aaguucuguc caa                                                          13


<210> 9193
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9193
aaguucuguc ca                                                           12


<210> 9194
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9194
aaguucuguc c                                                            11


<210> 9195
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9195
aaguucuguc                                                              10


<210> 9196
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9196
aaguucugu                                                                9


<210> 9197
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9197
aaguucug                                                                 8


<210> 9198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9198
taaguucugu ccaagcccgg                                                   20


<210> 9199
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9199
taaguucugu ccaagcccg                                                    19


<210> 9200
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9200
taaguucugu ccaagccc                                                     18


<210> 9201
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9201
taaguucugu ccaagcc                                                      17


<210> 9202
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9202
taaguucugu ccaagc                                                       16


<210> 9203
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9203
taaguucugu ccaa                                                         14


<210> 9204
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9204
taaguucugu cca                                                          13


<210> 9205
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9205
taaguucugu cc                                                           12


<210> 9206
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9206
taaguucugu c                                                            11


<210> 9207
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9207
taaguucugu                                                              10


<210> 9208
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9208
taaguucug                                                                9


<210> 9209
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9209
taaguucu                                                                 8


<210> 9210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9210
gtaaguucug uccaagcccg                                                   20


<210> 9211
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9211
gtaaguucug uccaagccc                                                    19


<210> 9212
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9212
gtaaguucug uccaagc                                                      17


<210> 9213
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9213
gtaaguucug uccaag                                                       16


<210> 9214
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9214
gtaaguucug uccaa                                                        15


<210> 9215
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9215
gtaaguucug ucca                                                         14


<210> 9216
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9216
gtaaguucug ucc                                                          13


<210> 9217
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9217
gtaaguucug uc                                                           12


<210> 9218
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9218
gtaaguucug u                                                            11


<210> 9219
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9219
gtaaguucug                                                              10


<210> 9220
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9220
gtaaguucu                                                                9


<210> 9221
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9221
gtaaguuc                                                                 8


<210> 9222
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9222
gguaaguucu guccaagccc                                                   20


<210> 9223
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9223
gguaaguucu guccaagcc                                                    19


<210> 9224
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9224
gguaaguucu guccaag                                                      17


<210> 9225
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9225
gguaaguucu guccaa                                                       16


<210> 9226
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9226
gguaaguucu gucca                                                        15


<210> 9227
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9227
gguaaguucu gucc                                                         14


<210> 9228
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9228
gguaaguucu guc                                                          13


<210> 9229
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9229
gguaaguucu gu                                                           12


<210> 9230
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9230
gguaaguucu g                                                            11


<210> 9231
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9231
gguaaguucu                                                              10


<210> 9232
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9232
gguaaguuc                                                                9


<210> 9233
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9233
gguaaguu                                                                 8


<210> 9234
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9234
cgguaaguuc uguccaagcc                                                   20


<210> 9235
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9235
cgguaaguuc uguccaagc                                                    19


<210> 9236
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9236
cgguaaguuc uguccaag                                                     18


<210> 9237
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9237
cgguaaguuc uguccaa                                                      17


<210> 9238
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9238
cgguaaguuc ugucca                                                       16


<210> 9239
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9239
cgguaaguuc ugucc                                                        15


<210> 9240
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9240
cgguaaguuc uguc                                                         14


<210> 9241
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9241
cgguaaguuc ugu                                                          13


<210> 9242
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9242
cgguaaguuc ug                                                           12


<210> 9243
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9243
cgguaaguuc u                                                            11


<210> 9244
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9244
cgguaaguuc                                                              10


<210> 9245
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9245
cgguaaguu                                                                9


<210> 9246
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9246
cgguaagu                                                                 8


<210> 9247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9247
tcgguaaguu cuguccaagc                                                   20


<210> 9248
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9248
tcgguaaguu cuguccaag                                                    19


<210> 9249
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9249
tcgguaaguu cuguccaa                                                     18


<210> 9250
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9250
tcgguaaguu cugucca                                                      17


<210> 9251
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9251
tcgguaaguu cugucc                                                       16


<210> 9252
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9252
tcgguaaguu cuguc                                                        15


<210> 9253
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9253
tcgguaaguu cugu                                                         14


<210> 9254
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9254
tcgguaaguu cug                                                          13


<210> 9255
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9255
tcgguaaguu cu                                                           12


<210> 9256
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9256
tcgguaaguu c                                                            11


<210> 9257
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9257
tcgguaaguu                                                              10


<210> 9258
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9258
tcgguaagu                                                                9


<210> 9259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9259
gtcgguaagu ucuguccaag                                                   20


<210> 9260
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9260
gtcgguaagu ucuguccaa                                                    19


<210> 9261
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9261
gtcgguaagu ucugucca                                                     18


<210> 9262
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9262
gtcgguaagu ucugucc                                                      17


<210> 9263
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9263
gtcgguaagu ucuguc                                                       16


<210> 9264
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9264
gtcgguaagu ucugu                                                        15


<210> 9265
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9265
gtcgguaagu ucug                                                         14


<210> 9266
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9266
gtcgguaagu ucu                                                          13


<210> 9267
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9267
gtcgguaagu uc                                                           12


<210> 9268
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9268
gtcgguaagu u                                                            11


<210> 9269
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9269
gtcgguaagu                                                              10


<210> 9270
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9270
agucgguaag uucuguccaa                                                   20


<210> 9271
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9271
agucgguaag uucugucca                                                    19


<210> 9272
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9272
agucgguaag uucuguc                                                      17


<210> 9273
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9273
agucgguaag uucugu                                                       16


<210> 9274
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9274
agucgguaag uucug                                                        15


<210> 9275
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9275
agucgguaag uucu                                                         14


<210> 9276
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9276
agucgguaag uuc                                                          13


<210> 9277
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9277
agucgguaag uu                                                           12


<210> 9278
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9278
agucgguaag u                                                            11


<210> 9279
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9279
cagucgguaa guucugucca                                                   20


<210> 9280
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9280
cagucgguaa guucugucc                                                    19


<210> 9281
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9281
cagucgguaa guucuguc                                                     18


<210> 9282
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9282
cagucgguaa guucugu                                                      17


<210> 9283
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9283
cagucgguaa guucug                                                       16


<210> 9284
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9284
cagucgguaa guucu                                                        15


<210> 9285
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9285
cagucgguaa guuc                                                         14


<210> 9286
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9286
cagucgguaa guu                                                          13


<210> 9287
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9287
cagucgguaa gu                                                           12


<210> 9288
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9288
ccagucggua aguucugucc                                                   20


<210> 9289
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9289
ccagucggua aguucuguc                                                    19


<210> 9290
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9290
ccagucggua aguucugu                                                     18


<210> 9291
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9291
ccagucggua aguucug                                                      17


<210> 9292
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9292
ccagucggua aguucu                                                       16


<210> 9293
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9293
ccagucggua aguuc                                                        15


<210> 9294
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9294
ccagucggua aguu                                                         14


<210> 9295
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9295
ccagucggua agu                                                          13


<210> 9296
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9296
gccagucggu aaguucuguc                                                   20


<210> 9297
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9297
gccagucggu aaguucugu                                                    19


<210> 9298
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9298
gccagucggu aaguucug                                                     18


<210> 9299
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9299
gccagucggu aaguucu                                                      17


<210> 9300
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9300
gccagucggu aaguuc                                                       16


<210> 9301
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9301
gccagucggu aaguu                                                        15


<210> 9302
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9302
gccagucggu aagu                                                         14


<210> 9303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9303
tcaaggaaga uggcauuucu                                                   20


<210> 9304
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9304
tcaaggaaga uggcauuucu ag                                                22


<210> 9305
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9305
tcaaggaaga uggcau                                                       16


<210> 9306
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9306
gaagauggca uuucu                                                        15


<210> 9307
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9307
tcaaggaaga uggcauuucu a                                                 21


<210> 9308
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9308
tcaaggaaga uggcauuuc                                                    19


<210> 9309
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9309
tcaaggaaga uggcauuu                                                     18


<210> 9310
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9310
tcaaggaaga uggcauu                                                      17


<210> 9311
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9311
tcaaggaaga uggca                                                        15


<210> 9312
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9312
tcaaggaaga uggc                                                         14


<210> 9313
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9313
tcaaggaaga ugg                                                          13


<210> 9314
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9314
tcaaggaaga ug                                                           12


<210> 9315
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9315
tcaaggaaga u                                                            11


<210> 9316
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9316
tcaaggaaga                                                              10


<210> 9317
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9317
tcaaggaag                                                                9


<210> 9318
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9318
caaggaagau ggcauuucua g                                                 21


<210> 9319
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9319
caaggaagau ggcauuucua                                                   20


<210> 9320
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9320
caaggaagau ggcauuucu                                                    19


<210> 9321
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9321
caaggaagau ggcauuuc                                                     18


<210> 9322
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9322
caaggaagau ggcauuu                                                      17


<210> 9323
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9323
caaggaagau ggcauu                                                       16


<210> 9324
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9324
caaggaagau ggcau                                                        15


<210> 9325
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9325
caaggaagau ggca                                                         14


<210> 9326
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9326
caaggaagau ggc                                                          13


<210> 9327
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9327
caaggaagau gg                                                           12


<210> 9328
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9328
caaggaagau g                                                            11


<210> 9329
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9329
caaggaagau                                                              10


<210> 9330
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9330
caaggaaga                                                                9


<210> 9331
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9331
caaggaag                                                                 8


<210> 9332
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9332
aaggaagaug gcauuucuag                                                   20


<210> 9333
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9333
aaggaagaug gcauuucua                                                    19


<210> 9334
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9334
aaggaagaug gcauuucu                                                     18


<210> 9335
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9335
aaggaagaug gcauuuc                                                      17


<210> 9336
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9336
aaggaagaug gcauuu                                                       16


<210> 9337
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9337
aaggaagaug gcauu                                                        15


<210> 9338
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9338
aaggaagaug gcau                                                         14


<210> 9339
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9339
aaggaagaug gca                                                          13


<210> 9340
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9340
aaggaagaug gc                                                           12


<210> 9341
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9341
aaggaagaug g                                                            11


<210> 9342
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9342
aaggaagaug                                                              10


<210> 9343
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9343
aaggaagau                                                                9


<210> 9344
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9344
aaggaaga                                                                 8


<210> 9345
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9345
aggaagaugg cauuucuag                                                    19


<210> 9346
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9346
aggaagaugg cauuucua                                                     18


<210> 9347
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9347
aggaagaugg cauuucu                                                      17


<210> 9348
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9348
aggaagaugg cauuuc                                                       16


<210> 9349
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9349
aggaagaugg cauuu                                                        15


<210> 9350
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9350
aggaagaugg cauu                                                         14


<210> 9351
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9351
aggaagaugg cau                                                          13


<210> 9352
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9352
aggaagaugg ca                                                           12


<210> 9353
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9353
aggaagaugg                                                              10


<210> 9354
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9354
aggaagaug                                                                9


<210> 9355
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9355
aggaagau                                                                 8


<210> 9356
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9356
ggaagauggc auuucuag                                                     18


<210> 9357
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9357
ggaagauggc auuucua                                                      17


<210> 9358
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9358
ggaagauggc auuucu                                                       16


<210> 9359
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9359
ggaagauggc auuuc                                                        15


<210> 9360
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9360
ggaagauggc auuu                                                         14


<210> 9361
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9361
ggaagauggc auu                                                          13


<210> 9362
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9362
ggaagauggc au                                                           12


<210> 9363
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9363
ggaagauggc a                                                            11


<210> 9364
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9364
ggaagauggc                                                              10


<210> 9365
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9365
ggaagaug                                                                 8


<210> 9366
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9366
gaagauggca uuucuag                                                      17


<210> 9367
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9367
gaagauggca uuucua                                                       16


<210> 9368
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9368
gaagauggca uuuc                                                         14


<210> 9369
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9369
gaagauggca uuu                                                          13


<210> 9370
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9370
gaagauggca uu                                                           12


<210> 9371
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9371
gaagauggca u                                                            11


<210> 9372
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9372
gaagauggca                                                              10


<210> 9373
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9373
gaagauggc                                                                9


<210> 9374
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9374
gaagaugg                                                                 8


<210> 9375
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9375
aagauggcau uucuag                                                       16


<210> 9376
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9376
aagauggcau uucua                                                        15


<210> 9377
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9377
aagauggcau uucu                                                         14


<210> 9378
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9378
aagauggcau uuc                                                          13


<210> 9379
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9379
aagauggcau uu                                                           12


<210> 9380
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9380
aagauggcau u                                                            11


<210> 9381
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9381
aagauggcau                                                              10


<210> 9382
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9382
aagauggca                                                                9


<210> 9383
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9383
aagauggc                                                                 8


<210> 9384
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9384
agauggcauu ucuag                                                        15


<210> 9385
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9385
agauggcauu ucua                                                         14


<210> 9386
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9386
agauggcauu ucu                                                          13


<210> 9387
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9387
agauggcauu uc                                                           12


<210> 9388
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9388
agauggcauu u                                                            11


<210> 9389
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9389
agauggcauu                                                              10


<210> 9390
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9390
agauggcau                                                                9


<210> 9391
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9391
agauggca                                                                 8


<210> 9392
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9392
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 9393
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9393
ctccaacauc aaggaagaug gcauuucua                                         29


<210> 9394
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9394
ctccaacauc aaggaagaug gcauuucu                                          28


<210> 9395
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9395
ctccaacauc aaggaagaug gcauuuc                                           27


<210> 9396
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9396
ctccaacauc aaggaagaug gcauuu                                            26


<210> 9397
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9397
ctccaacauc aaggaagaug gcauu                                             25


<210> 9398
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9398
ctccaacauc aaggaagaug gcau                                              24


<210> 9399
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9399
ctccaacauc aaggaagaug gca                                               23


<210> 9400
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9400
ctccaacauc aaggaagaug gc                                                22


<210> 9401
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9401
ctccaacauc aaggaagaug g                                                 21


<210> 9402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9402
ctccaacauc aaggaagaug                                                   20


<210> 9403
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9403
ctccaacauc aaggaagau                                                    19


<210> 9404
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9404
ctccaacauc aaggaaga                                                     18


<210> 9405
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9405
ctccaacauc aaggaag                                                      17


<210> 9406
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9406
tccaacauca aggaagaugg cauuucuag                                         29


<210> 9407
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9407
tccaacauca aggaagaugg cauuucua                                          28


<210> 9408
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9408
tccaacauca aggaagaugg cauuucu                                           27


<210> 9409
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9409
tccaacauca aggaagaugg cauuuc                                            26


<210> 9410
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9410
tccaacauca aggaagaugg cauuu                                             25


<210> 9411
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9411
tccaacauca aggaagaugg cauu                                              24


<210> 9412
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9412
tccaacauca aggaagaugg cau                                               23


<210> 9413
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9413
tccaacauca aggaagaugg ca                                                22


<210> 9414
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9414
tccaacauca aggaagaugg c                                                 21


<210> 9415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9415
tccaacauca aggaagaugg                                                   20


<210> 9416
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9416
tccaacauca aggaagaug                                                    19


<210> 9417
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9417
tccaacauca aggaagau                                                     18


<210> 9418
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9418
tccaacauca aggaaga                                                      17


<210> 9419
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9419
tccaacauca aggaag                                                       16


<210> 9420
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9420
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 9421
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9421
ccaacaucaa ggaagauggc auuucua                                           27


<210> 9422
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9422
ccaacaucaa ggaagauggc auuucu                                            26


<210> 9423
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9423
ccaacaucaa ggaagauggc auuuc                                             25


<210> 9424
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9424
ccaacaucaa ggaagauggc auuu                                              24


<210> 9425
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9425
ccaacaucaa ggaagauggc auu                                               23


<210> 9426
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9426
ccaacaucaa ggaagauggc au                                                22


<210> 9427
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9427
ccaacaucaa ggaagauggc a                                                 21


<210> 9428
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9428
ccaacaucaa ggaagauggc                                                   20


<210> 9429
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9429
ccaacaucaa ggaagaugg                                                    19


<210> 9430
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9430
ccaacaucaa ggaagaug                                                     18


<210> 9431
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9431
ccaacaucaa ggaagau                                                      17


<210> 9432
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9432
ccaacaucaa ggaaga                                                       16


<210> 9433
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9433
ccaacaucaa ggaag                                                        15


<210> 9434
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9434
caacaucaag gaagauggca uuucuag                                           27


<210> 9435
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9435
caacaucaag gaagauggca uuucua                                            26


<210> 9436
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9436
caacaucaag gaagauggca uuucu                                             25


<210> 9437
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9437
caacaucaag gaagauggca uuuc                                              24


<210> 9438
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9438
caacaucaag gaagauggca uuu                                               23


<210> 9439
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9439
caacaucaag gaagauggca uu                                                22


<210> 9440
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9440
caacaucaag gaagauggca u                                                 21


<210> 9441
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9441
caacaucaag gaagauggca                                                   20


<210> 9442
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9442
caacaucaag gaagauggc                                                    19


<210> 9443
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9443
caacaucaag gaagaugg                                                     18


<210> 9444
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9444
caacaucaag gaagaug                                                      17


<210> 9445
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9445
caacaucaag gaagau                                                       16


<210> 9446
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9446
caacaucaag gaaga                                                        15


<210> 9447
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9447
caacaucaag gaag                                                         14


<210> 9448
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9448
aacaucaagg aagauggcau uucuag                                            26


<210> 9449
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9449
aacaucaagg aagauggcau uucua                                             25


<210> 9450
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9450
aacaucaagg aagauggcau uucu                                              24


<210> 9451
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9451
aacaucaagg aagauggcau uuc                                               23


<210> 9452
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9452
aacaucaagg aagauggcau uu                                                22


<210> 9453
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9453
aacaucaagg aagauggcau u                                                 21


<210> 9454
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9454
aacaucaagg aagauggcau                                                   20


<210> 9455
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9455
aacaucaagg aagauggca                                                    19


<210> 9456
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9456
aacaucaagg aagauggc                                                     18


<210> 9457
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9457
aacaucaagg aagaugg                                                      17


<210> 9458
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9458
aacaucaagg aagaug                                                       16


<210> 9459
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9459
aacaucaagg aagau                                                        15


<210> 9460
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9460
aacaucaagg aaga                                                         14


<210> 9461
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9461
aacaucaagg aag                                                          13


<210> 9462
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9462
acaucaagga agauggcauu ucuag                                             25


<210> 9463
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9463
acaucaagga agauggcauu ucua                                              24


<210> 9464
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9464
acaucaagga agauggcauu ucu                                               23


<210> 9465
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9465
acaucaagga agauggcauu uc                                                22


<210> 9466
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9466
acaucaagga agauggcauu u                                                 21


<210> 9467
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9467
acaucaagga agauggcauu                                                   20


<210> 9468
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9468
acaucaagga agauggcau                                                    19


<210> 9469
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9469
acaucaagga agauggca                                                     18


<210> 9470
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9470
acaucaagga agauggc                                                      17


<210> 9471
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9471
acaucaagga agaugg                                                       16


<210> 9472
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9472
acaucaagga agaug                                                        15


<210> 9473
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9473
acaucaagga agau                                                         14


<210> 9474
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9474
acaucaagga aga                                                          13


<210> 9475
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9475
acaucaagga ag                                                           12


<210> 9476
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9476
caucaaggaa gauggcauuu cuag                                              24


<210> 9477
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9477
caucaaggaa gauggcauuu cua                                               23


<210> 9478
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9478
caucaaggaa gauggcauuu cu                                                22


<210> 9479
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9479
caucaaggaa gauggcauuu c                                                 21


<210> 9480
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9480
caucaaggaa gauggcauuu                                                   20


<210> 9481
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9481
caucaaggaa gauggcauu                                                    19


<210> 9482
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9482
caucaaggaa gauggcau                                                     18


<210> 9483
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9483
caucaaggaa gauggca                                                      17


<210> 9484
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9484
caucaaggaa gauggc                                                       16


<210> 9485
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9485
caucaaggaa gaugg                                                        15


<210> 9486
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9486
caucaaggaa gaug                                                         14


<210> 9487
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9487
caucaaggaa gau                                                          13


<210> 9488
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9488
caucaaggaa ga                                                           12


<210> 9489
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9489
caucaaggaa g                                                            11


<210> 9490
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9490
atcaaggaag auggcauuuc uag                                               23


<210> 9491
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9491
atcaaggaag auggcauuuc ua                                                22


<210> 9492
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9492
atcaaggaag auggcauuuc u                                                 21


<210> 9493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9493
atcaaggaag auggcauuuc                                                   20


<210> 9494
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9494
atcaaggaag auggcauuu                                                    19


<210> 9495
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9495
atcaaggaag auggcauu                                                     18


<210> 9496
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9496
atcaaggaag auggcau                                                      17


<210> 9497
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9497
atcaaggaag auggca                                                       16


<210> 9498
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9498
atcaaggaag auggc                                                        15


<210> 9499
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9499
atcaaggaag augg                                                         14


<210> 9500
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9500
atcaaggaag aug                                                          13


<210> 9501
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9501
atcaaggaag au                                                           12


<210> 9502
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9502
atcaaggaag a                                                            11


<210> 9503
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9503
atcaaggaag                                                              10


<210> 9504
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9504
ccagagcagg uaccuccaac auc                                               23


<210> 9505
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9505
ccagagcagg uaccucca                                                     18


<210> 9506
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9506
ccucugugau uuuauaacuu gau                                               23


<210> 9507
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9507
tcacccacca ucacccu                                                      17


<210> 9508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9508
tgauauccuc aaggucaccc                                                   20


<210> 9509
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9509
ctgcuugaug aucaucucgu ug                                                22


<210> 9510
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9510
ctgcuugaug aucaucuc                                                     18


<210> 9511
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9511
gtuuccuuag uaaccacag                                                    19


<210> 9512
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 9512
gtuuccuuag uaaccac                                                      17


<210> 9513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9513
ucaaggaaga uggcauuuct                                                   20


<210> 9514
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9514
ucaaggaaga uggcauuucu ag                                                22


<210> 9515
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9515
gguaaguucu guccaagc                                                     18


<210> 9516
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9516
guaaguucug uccaagcc                                                     18


<210> 9517
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9517
agucgguaag uucugucc                                                     18


<210> 9518
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9518
cuguccaagc ccgguuga                                                     18


<210> 9519
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9519
uaaguucugu ccaag                                                        15


<210> 9520
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9520
uucuguccaa gcccgguuga                                                   20


<210> 9521
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9521
uucuguccaa gcccggutg                                                    19


<210> 9522
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9522
uucuguccaa gcccggtt                                                     18


<210> 9523
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9523
uucuguccaa gcccggt                                                      17


<210> 9524
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9524
uucuguccaa gcccgg                                                       16


<210> 9525
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9525
uucuguccaa gcccg                                                        15


<210> 9526
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9526
uucuguccaa gccc                                                         14


<210> 9527
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9527
uucuguccaa gcc                                                          13


<210> 9528
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9528
uucuguccaa gc                                                           12


<210> 9529
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9529
uucuguccaa g                                                            11


<210> 9530
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9530
uucuguccaa                                                              10


<210> 9531
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9531
uucugucca                                                                9


<210> 9532
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9532
uucugucc                                                                 8


<210> 9533
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9533
ucuguccaag cccgguuga                                                    19


<210> 9534
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9534
ucuguccaag cccggutg                                                     18


<210> 9535
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9535
ucuguccaag cccggtt                                                      17


<210> 9536
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9536
ucuguccaag cccggt                                                       16


<210> 9537
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9537
ucuguccaag cccgg                                                        15


<210> 9538
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9538
ucuguccaag cccg                                                         14


<210> 9539
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9539
ucuguccaag ccc                                                          13


<210> 9540
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9540
ucuguccaag cc                                                           12


<210> 9541
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9541
ucuguccaag c                                                            11


<210> 9542
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9542
ucuguccaag                                                              10


<210> 9543
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9543
ucuguccaa                                                                9


<210> 9544
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9544
ucugucca                                                                 8


<210> 9545
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9545
cuguccaagc ccggutg                                                      17


<210> 9546
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9546
cuguccaagc ccggtt                                                       16


<210> 9547
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9547
cuguccaagc ccggt                                                        15


<210> 9548
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9548
cuguccaagc ccgg                                                         14


<210> 9549
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9549
cuguccaagc ccg                                                          13


<210> 9550
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9550
cuguccaagc cc                                                           12


<210> 9551
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9551
cuguccaagc c                                                            11


<210> 9552
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9552
cuguccaagc                                                              10


<210> 9553
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9553
cuguccaag                                                                9


<210> 9554
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9554
cuguccaa                                                                 8


<210> 9555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9555
guucugucca agcccggutg                                                   20


<210> 9556
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9556
guucugucca agcccggtt                                                    19


<210> 9557
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9557
guucugucca agcccggt                                                     18


<210> 9558
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9558
guucugucca agcccgg                                                      17


<210> 9559
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9559
guucugucca agcccg                                                       16


<210> 9560
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9560
guucugucca agccc                                                        15


<210> 9561
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9561
guucugucca agcc                                                         14


<210> 9562
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9562
guucugucca agc                                                          13


<210> 9563
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9563
guucugucca ag                                                           12


<210> 9564
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9564
guucugucca a                                                            11


<210> 9565
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9565
guucugucca                                                              10


<210> 9566
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9566
guucugucc                                                                9


<210> 9567
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9567
guucugtc                                                                 8


<210> 9568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9568
aguucugucc aagcccggtt                                                   20


<210> 9569
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9569
aguucugucc aagcccggt                                                    19


<210> 9570
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9570
aguucugucc aagcccgg                                                     18


<210> 9571
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9571
aguucugucc aagcccg                                                      17


<210> 9572
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9572
aguucugucc aagccc                                                       16


<210> 9573
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9573
aguucugucc aagcc                                                        15


<210> 9574
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9574
aguucugucc aagc                                                         14


<210> 9575
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9575
aguucugucc aag                                                          13


<210> 9576
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9576
aguucugucc aa                                                           12


<210> 9577
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9577
aguucugucc a                                                            11


<210> 9578
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9578
aguucugucc                                                              10


<210> 9579
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9579
aguucugtc                                                                9


<210> 9580
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9580
aguucugt                                                                 8


<210> 9581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9581
aaguucuguc caagcccggt                                                   20


<210> 9582
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9582
aaguucuguc caagcccgg                                                    19


<210> 9583
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9583
aaguucuguc caagcccg                                                     18


<210> 9584
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9584
aaguucuguc caagccc                                                      17


<210> 9585
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9585
aaguucuguc caagcc                                                       16


<210> 9586
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9586
aaguucuguc caagc                                                        15


<210> 9587
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9587
aaguucuguc caag                                                         14


<210> 9588
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9588
aaguucuguc caa                                                          13


<210> 9589
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9589
aaguucuguc ca                                                           12


<210> 9590
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9590
aaguucuguc c                                                            11


<210> 9591
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9591
aaguucugtc                                                              10


<210> 9592
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9592
aaguucugt                                                                9


<210> 9593
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9593
aaguuctg                                                                 8


<210> 9594
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9594
uaaguucugu ccaagcccgg                                                   20


<210> 9595
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9595
uaaguucugu ccaagcccg                                                    19


<210> 9596
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9596
uaaguucugu ccaagccc                                                     18


<210> 9597
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9597
uaaguucugu ccaagcc                                                      17


<210> 9598
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9598
uaaguucugu ccaagc                                                       16


<210> 9599
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9599
uaaguucugu ccaa                                                         14


<210> 9600
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9600
uaaguucugu cca                                                          13


<210> 9601
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9601
uaaguucugu cc                                                           12


<210> 9602
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9602
uaaguucugt c                                                            11


<210> 9603
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9603
uaaguucugt                                                              10


<210> 9604
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9604
uaaguuctg                                                                9


<210> 9605
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9605
uaaguuct                                                                 8


<210> 9606
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9606
guaaguucug uccaagcccg                                                   20


<210> 9607
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9607
guaaguucug uccaagccc                                                    19


<210> 9608
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9608
guaaguucug uccaagc                                                      17


<210> 9609
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9609
guaaguucug uccaag                                                       16


<210> 9610
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9610
guaaguucug uccaa                                                        15


<210> 9611
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9611
guaaguucug ucca                                                         14


<210> 9612
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9612
guaaguucug ucc                                                          13


<210> 9613
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9613
guaaguucug tc                                                           12


<210> 9614
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9614
guaaguucug t                                                            11


<210> 9615
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9615
guaaguuctg                                                              10


<210> 9616
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9616
guaaguuct                                                                9


<210> 9617
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9617
guaagutc                                                                 8


<210> 9618
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9618
gguaaguucu guccaagccc                                                   20


<210> 9619
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9619
gguaaguucu guccaagcc                                                    19


<210> 9620
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9620
gguaaguucu guccaag                                                      17


<210> 9621
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9621
gguaaguucu guccaa                                                       16


<210> 9622
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9622
gguaaguucu gucca                                                        15


<210> 9623
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9623
gguaaguucu gucc                                                         14


<210> 9624
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9624
gguaaguucu gtc                                                          13


<210> 9625
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9625
gguaaguucu gt                                                           12


<210> 9626
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9626
gguaaguuct g                                                            11


<210> 9627
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9627
gguaaguuct                                                              10


<210> 9628
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9628
gguaagutc                                                                9


<210> 9629
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9629
gguaagtt                                                                 8


<210> 9630
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9630
cgguaaguuc uguccaagcc                                                   20


<210> 9631
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9631
cgguaaguuc uguccaagc                                                    19


<210> 9632
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9632
cgguaaguuc uguccaag                                                     18


<210> 9633
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9633
cgguaaguuc uguccaa                                                      17


<210> 9634
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9634
cgguaaguuc ugucca                                                       16


<210> 9635
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9635
cgguaaguuc ugucc                                                        15


<210> 9636
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9636
cgguaaguuc ugtc                                                         14


<210> 9637
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9637
cgguaaguuc ugt                                                          13


<210> 9638
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9638
cgguaaguuc tg                                                           12


<210> 9639
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9639
cgguaaguuc t                                                            11


<210> 9640
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9640
cgguaagutc                                                              10


<210> 9641
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9641
cgguaagtt                                                                9


<210> 9642
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9642
cgguaagt                                                                 8


<210> 9643
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9643
ucgguaaguu cuguccaagc                                                   20


<210> 9644
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9644
ucgguaaguu cuguccaag                                                    19


<210> 9645
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9645
ucgguaaguu cuguccaa                                                     18


<210> 9646
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9646
ucgguaaguu cugucca                                                      17


<210> 9647
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9647
ucgguaaguu cugucc                                                       16


<210> 9648
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9648
ucgguaaguu cugtc                                                        15


<210> 9649
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9649
ucgguaaguu cugt                                                         14


<210> 9650
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9650
ucgguaaguu ctg                                                          13


<210> 9651
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9651
ucgguaaguu ct                                                           12


<210> 9652
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9652
ucgguaagut c                                                            11


<210> 9653
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9653
ucgguaagtt                                                              10


<210> 9654
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9654
ucgguaagt                                                                9


<210> 9655
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9655
gucgguaagu ucuguccaag                                                   20


<210> 9656
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9656
gucgguaagu ucuguccaa                                                    19


<210> 9657
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9657
gucgguaagu ucugucca                                                     18


<210> 9658
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9658
gucgguaagu ucugucc                                                      17


<210> 9659
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9659
gucgguaagu ucugtc                                                       16


<210> 9660
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9660
gucgguaagu ucugt                                                        15


<210> 9661
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9661
gucgguaagu uctg                                                         14


<210> 9662
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9662
gucgguaagu uct                                                          13


<210> 9663
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9663
gucgguaagu tc                                                           12


<210> 9664
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9664
gucgguaagt t                                                            11


<210> 9665
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9665
gucgguaagt                                                              10


<210> 9666
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9666
agucgguaag uucuguccaa                                                   20


<210> 9667
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9667
agucgguaag uucugucca                                                    19


<210> 9668
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9668
agucgguaag uucugtc                                                      17


<210> 9669
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9669
agucgguaag uucugt                                                       16


<210> 9670
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9670
agucgguaag uuctg                                                        15


<210> 9671
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9671
agucgguaag uuct                                                         14


<210> 9672
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9672
agucgguaag utc                                                          13


<210> 9673
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9673
agucgguaag tt                                                           12


<210> 9674
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9674
agucgguaag t                                                            11


<210> 9675
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9675
cagucgguaa guucugucca                                                   20


<210> 9676
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9676
cagucgguaa guucugucc                                                    19


<210> 9677
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9677
cagucgguaa guucugtc                                                     18


<210> 9678
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9678
cagucgguaa guucugt                                                      17


<210> 9679
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9679
cagucgguaa guuctg                                                       16


<210> 9680
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9680
cagucgguaa guuct                                                        15


<210> 9681
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9681
cagucgguaa gutc                                                         14


<210> 9682
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9682
cagucgguaa gtt                                                          13


<210> 9683
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9683
cagucgguaa gt                                                           12


<210> 9684
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9684
ccagucggua aguucugucc                                                   20


<210> 9685
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9685
ccagucggua aguucugtc                                                    19


<210> 9686
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9686
ccagucggua aguucugt                                                     18


<210> 9687
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9687
ccagucggua aguuctg                                                      17


<210> 9688
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9688
ccagucggua aguuct                                                       16


<210> 9689
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9689
ccagucggua agutc                                                        15


<210> 9690
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9690
ccagucggua agtt                                                         14


<210> 9691
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9691
ccagucggua agt                                                          13


<210> 9692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9692
gccagucggu aaguucugtc                                                   20


<210> 9693
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9693
gccagucggu aaguucugt                                                    19


<210> 9694
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9694
gccagucggu aaguuctg                                                     18


<210> 9695
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9695
gccagucggu aaguuct                                                      17


<210> 9696
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9696
gccagucggu aagutc                                                       16


<210> 9697
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9697
gccagucggu aagtt                                                        15


<210> 9698
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9698
gccagucggu aagt                                                         14


<210> 9699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9699
ucaaggaaga uggcauuuct                                                   20


<210> 9700
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9700
ucaaggaaga uggcauuucu ag                                                22


<210> 9701
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9701
ucaaggaaga uggcat                                                       16


<210> 9702
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9702
gaagauggca uuuct                                                        15


<210> 9703
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 9703
ucaaggaaga uggcauuuct a                                                 21


<210> 9704
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9704
ucaaggaaga uggcauutc                                                    19


<210> 9705
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9705
ucaaggaaga uggcautt                                                     18


<210> 9706
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9706
ucaaggaaga uggcatt                                                      17


<210> 9707
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9707
ucaaggaaga uggca                                                        15


<210> 9708
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9708
ucaaggaaga uggc                                                         14


<210> 9709
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9709
ucaaggaaga ugg                                                          13


<210> 9710
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9710
ucaaggaaga tg                                                           12


<210> 9711
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9711
ucaaggaaga t                                                            11


<210> 9712
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9712
ucaaggaaga                                                              10


<210> 9713
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9713
ucaaggaag                                                                9


<210> 9714
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 9714
caaggaagau ggcauuucua g                                                 21


<210> 9715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9715
caaggaagau ggcauuucta                                                   20


<210> 9716
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9716
caaggaagau ggcauuuct                                                    19


<210> 9717
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9717
caaggaagau ggcauutc                                                     18


<210> 9718
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9718
caaggaagau ggcautt                                                      17


<210> 9719
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9719
caaggaagau ggcatt                                                       16


<210> 9720
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9720
caaggaagau ggcat                                                        15


<210> 9721
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9721
caaggaagau ggca                                                         14


<210> 9722
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9722
caaggaagau ggc                                                          13


<210> 9723
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9723
caaggaagau gg                                                           12


<210> 9724
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9724
caaggaagat g                                                            11


<210> 9725
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9725
caaggaagat                                                              10


<210> 9726
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9726
caaggaaga                                                                9


<210> 9727
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9727
caaggaag                                                                 8


<210> 9728
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9728
aaggaagaug gcauuucuag                                                   20


<210> 9729
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9729
aaggaagaug gcauuucta                                                    19


<210> 9730
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9730
aaggaagaug gcauuuct                                                     18


<210> 9731
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9731
aaggaagaug gcauutc                                                      17


<210> 9732
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9732
aaggaagaug gcautt                                                       16


<210> 9733
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9733
aaggaagaug gcatt                                                        15


<210> 9734
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9734
aaggaagaug gcat                                                         14


<210> 9735
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9735
aaggaagaug gca                                                          13


<210> 9736
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9736
aaggaagaug gc                                                           12


<210> 9737
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9737
aaggaagaug g                                                            11


<210> 9738
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9738
aaggaagatg                                                              10


<210> 9739
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9739
aaggaagat                                                                9


<210> 9740
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9740
aaggaaga                                                                 8


<210> 9741
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9741
aggaagaugg cauuucuag                                                    19


<210> 9742
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9742
aggaagaugg cauuucta                                                     18


<210> 9743
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9743
aggaagaugg cauuuct                                                      17


<210> 9744
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9744
aggaagaugg cauutc                                                       16


<210> 9745
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9745
aggaagaugg cautt                                                        15


<210> 9746
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9746
aggaagaugg catt                                                         14


<210> 9747
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9747
aggaagaugg cat                                                          13


<210> 9748
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9748
aggaagaugg ca                                                           12


<210> 9749
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9749
aggaagaugg                                                              10


<210> 9750
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9750
aggaagatg                                                                9


<210> 9751
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9751
aggaagat                                                                 8


<210> 9752
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9752
ggaagauggc auuucuag                                                     18


<210> 9753
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9753
ggaagauggc auuucta                                                      17


<210> 9754
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9754
ggaagauggc auuuct                                                       16


<210> 9755
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9755
ggaagauggc auutc                                                        15


<210> 9756
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9756
ggaagauggc autt                                                         14


<210> 9757
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9757
ggaagauggc att                                                          13


<210> 9758
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9758
ggaagauggc at                                                           12


<210> 9759
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9759
ggaagauggc a                                                            11


<210> 9760
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9760
ggaagauggc                                                              10


<210> 9761
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9761
ggaagatg                                                                 8


<210> 9762
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9762
gaagauggca uuucuag                                                      17


<210> 9763
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9763
gaagauggca uuucta                                                       16


<210> 9764
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9764
gaagauggca uutc                                                         14


<210> 9765
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9765
gaagauggca utt                                                          13


<210> 9766
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9766
gaagauggca tt                                                           12


<210> 9767
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9767
gaagauggca t                                                            11


<210> 9768
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9768
gaagauggca                                                              10


<210> 9769
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9769
gaagauggc                                                                9


<210> 9770
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9770
gaagaugg                                                                 8


<210> 9771
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9771
aagauggcau uucuag                                                       16


<210> 9772
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9772
aagauggcau uucta                                                        15


<210> 9773
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9773
aagauggcau uuct                                                         14


<210> 9774
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9774
aagauggcau utc                                                          13


<210> 9775
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9775
aagauggcau tt                                                           12


<210> 9776
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9776
aagauggcat t                                                            11


<210> 9777
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9777
aagauggcat                                                              10


<210> 9778
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9778
aagauggca                                                                9


<210> 9779
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9779
aagauggc                                                                 8


<210> 9780
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9780
agauggcauu ucuag                                                        15


<210> 9781
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9781
agauggcauu ucta                                                         14


<210> 9782
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9782
agauggcauu uct                                                          13


<210> 9783
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9783
agauggcauu tc                                                           12


<210> 9784
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9784
agauggcaut t                                                            11


<210> 9785
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9785
agauggcatt                                                              10


<210> 9786
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9786
agauggcat                                                                9


<210> 9787
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9787
agauggca                                                                 8


<210> 9788
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 9788
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 9789
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 9789
cuccaacauc aaggaagaug gcauuucta                                         29


<210> 9790
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 9790
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 9791
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 9791
cuccaacauc aaggaagaug gcauutc                                           27


<210> 9792
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 9792
cuccaacauc aaggaagaug gcautt                                            26


<210> 9793
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 9793
cuccaacauc aaggaagaug gcatt                                             25


<210> 9794
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 9794
cuccaacauc aaggaagaug gcat                                              24


<210> 9795
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 9795
cuccaacauc aaggaagaug gca                                               23


<210> 9796
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9796
cuccaacauc aaggaagaug gc                                                22


<210> 9797
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 9797
cuccaacauc aaggaagaug g                                                 21


<210> 9798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9798
cuccaacauc aaggaagatg                                                   20


<210> 9799
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9799
cuccaacauc aaggaagat                                                    19


<210> 9800
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9800
cuccaacauc aaggaaga                                                     18


<210> 9801
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9801
cuccaacauc aaggaag                                                      17


<210> 9802
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 9802
uccaacauca aggaagaugg cauuucuag                                         29


<210> 9803
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 9803
uccaacauca aggaagaugg cauuucta                                          28


<210> 9804
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 9804
uccaacauca aggaagaugg cauuuct                                           27


<210> 9805
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 9805
uccaacauca aggaagaugg cauutc                                            26


<210> 9806
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 9806
uccaacauca aggaagaugg cautt                                             25


<210> 9807
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 9807
uccaacauca aggaagaugg catt                                              24


<210> 9808
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 9808
uccaacauca aggaagaugg cat                                               23


<210> 9809
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9809
uccaacauca aggaagaugg ca                                                22


<210> 9810
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 9810
uccaacauca aggaagaugg c                                                 21


<210> 9811
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9811
uccaacauca aggaagaugg                                                   20


<210> 9812
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9812
uccaacauca aggaagatg                                                    19


<210> 9813
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9813
uccaacauca aggaagat                                                     18


<210> 9814
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9814
uccaacauca aggaaga                                                      17


<210> 9815
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9815
uccaacauca aggaag                                                       16


<210> 9816
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 9816
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 9817
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 9817
ccaacaucaa ggaagauggc auuucta                                           27


<210> 9818
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 9818
ccaacaucaa ggaagauggc auuuct                                            26


<210> 9819
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 9819
ccaacaucaa ggaagauggc auutc                                             25


<210> 9820
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 9820
ccaacaucaa ggaagauggc autt                                              24


<210> 9821
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 9821
ccaacaucaa ggaagauggc att                                               23


<210> 9822
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9822
ccaacaucaa ggaagauggc at                                                22


<210> 9823
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 9823
ccaacaucaa ggaagauggc a                                                 21


<210> 9824
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9824
ccaacaucaa ggaagauggc                                                   20


<210> 9825
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9825
ccaacaucaa ggaagaugg                                                    19


<210> 9826
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9826
ccaacaucaa ggaagatg                                                     18


<210> 9827
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9827
ccaacaucaa ggaagat                                                      17


<210> 9828
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9828
ccaacaucaa ggaaga                                                       16


<210> 9829
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9829
ccaacaucaa ggaag                                                        15


<210> 9830
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 9830
caacaucaag gaagauggca uuucuag                                           27


<210> 9831
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 9831
caacaucaag gaagauggca uuucta                                            26


<210> 9832
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 9832
caacaucaag gaagauggca uuuct                                             25


<210> 9833
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 9833
caacaucaag gaagauggca uutc                                              24


<210> 9834
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 9834
caacaucaag gaagauggca utt                                               23


<210> 9835
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9835
caacaucaag gaagauggca tt                                                22


<210> 9836
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 9836
caacaucaag gaagauggca t                                                 21


<210> 9837
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9837
caacaucaag gaagauggca                                                   20


<210> 9838
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9838
caacaucaag gaagauggc                                                    19


<210> 9839
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9839
caacaucaag gaagaugg                                                     18


<210> 9840
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9840
caacaucaag gaagatg                                                      17


<210> 9841
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9841
caacaucaag gaagat                                                       16


<210> 9842
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9842
caacaucaag gaaga                                                        15


<210> 9843
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9843
caacaucaag gaag                                                         14


<210> 9844
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 9844
aacaucaagg aagauggcau uucuag                                            26


<210> 9845
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 9845
aacaucaagg aagauggcau uucta                                             25


<210> 9846
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 9846
aacaucaagg aagauggcau uuct                                              24


<210> 9847
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 9847
aacaucaagg aagauggcau utc                                               23


<210> 9848
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9848
aacaucaagg aagauggcau tt                                                22


<210> 9849
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 9849
aacaucaagg aagauggcat t                                                 21


<210> 9850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9850
aacaucaagg aagauggcat                                                   20


<210> 9851
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9851
aacaucaagg aagauggca                                                    19


<210> 9852
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9852
aacaucaagg aagauggc                                                     18


<210> 9853
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9853
aacaucaagg aagaugg                                                      17


<210> 9854
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9854
aacaucaagg aagatg                                                       16


<210> 9855
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9855
aacaucaagg aagat                                                        15


<210> 9856
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9856
aacaucaagg aaga                                                         14


<210> 9857
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9857
aacaucaagg aag                                                          13


<210> 9858
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 9858
acaucaagga agauggcauu ucuag                                             25


<210> 9859
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 9859
acaucaagga agauggcauu ucta                                              24


<210> 9860
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 9860
acaucaagga agauggcauu uct                                               23


<210> 9861
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9861
acaucaagga agauggcauu tc                                                22


<210> 9862
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 9862
acaucaagga agauggcaut t                                                 21


<210> 9863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9863
acaucaagga agauggcatt                                                   20


<210> 9864
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9864
acaucaagga agauggcat                                                    19


<210> 9865
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9865
acaucaagga agauggca                                                     18


<210> 9866
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9866
acaucaagga agauggc                                                      17


<210> 9867
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9867
acaucaagga agaugg                                                       16


<210> 9868
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9868
acaucaagga agatg                                                        15


<210> 9869
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9869
acaucaagga agat                                                         14


<210> 9870
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9870
acaucaagga aga                                                          13


<210> 9871
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9871
acaucaagga ag                                                           12


<210> 9872
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 9872
caucaaggaa gauggcauuu cuag                                              24


<210> 9873
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 9873
caucaaggaa gauggcauuu cta                                               23


<210> 9874
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9874
caucaaggaa gauggcauuu ct                                                22


<210> 9875
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 9875
caucaaggaa gauggcauut c                                                 21


<210> 9876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9876
caucaaggaa gauggcautt                                                   20


<210> 9877
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9877
caucaaggaa gauggcatt                                                    19


<210> 9878
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9878
caucaaggaa gauggcat                                                     18


<210> 9879
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9879
caucaaggaa gauggca                                                      17


<210> 9880
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9880
caucaaggaa gauggc                                                       16


<210> 9881
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9881
caucaaggaa gaugg                                                        15


<210> 9882
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9882
caucaaggaa gatg                                                         14


<210> 9883
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9883
caucaaggaa gat                                                          13


<210> 9884
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9884
caucaaggaa ga                                                           12


<210> 9885
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9885
caucaaggaa g                                                            11


<210> 9886
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 9886
aucaaggaag auggcauuuc uag                                               23


<210> 9887
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9887
aucaaggaag auggcauuuc ta                                                22


<210> 9888
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 9888
aucaaggaag auggcauuuc t                                                 21


<210> 9889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9889
aucaaggaag auggcauutc                                                   20


<210> 9890
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9890
aucaaggaag auggcautt                                                    19


<210> 9891
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9891
aucaaggaag auggcatt                                                     18


<210> 9892
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9892
aucaaggaag auggcat                                                      17


<210> 9893
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9893
aucaaggaag auggca                                                       16


<210> 9894
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9894
aucaaggaag auggc                                                        15


<210> 9895
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9895
aucaaggaag augg                                                         14


<210> 9896
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9896
aucaaggaag atg                                                          13


<210> 9897
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9897
aucaaggaag at                                                           12


<210> 9898
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9898
aucaaggaag a                                                            11


<210> 9899
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9899
aucaaggaag                                                              10


<210> 9900
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 9900
ccagagcagg uaccuccaac atc                                               23


<210> 9901
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9901
ccagagcagg uaccucca                                                     18


<210> 9902
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 9902
ccucugugau uuuauaacuu gat                                               23


<210> 9903
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9903
ucacccacca ucaccct                                                      17


<210> 9904
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9904
ugauauccuc aaggucaccc                                                   20


<210> 9905
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9905
cugcuugaug aucaucucgu tg                                                22


<210> 9906
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9906
cugcuugaug aucauctc                                                     18


<210> 9907
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9907
guuuccuuag uaaccacag                                                    19


<210> 9908
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9908
guuuccuuag uaaccac                                                      17


<210> 9909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9909
ucaaggaaga uggcauuuct                                                   20


<210> 9910
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 9910
ucaaggaaga uggcauuucu ag                                                22


<210> 9911
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9911
gguaaguucu guccaagc                                                     18


<210> 9912
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9912
guaaguucug uccaagcc                                                     18


<210> 9913
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9913
agucgguaag uucugucc                                                     18


<210> 9914
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9914
cuguccaagc ccgguuga                                                     18


<210> 9915
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9915
uaaguucugu ccaag                                                        15


<210> 9916
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9916
uucuguccaa gcccgguuga                                                   20


<210> 9917
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9917
uucuguccaa gcccggutg                                                    19


<210> 9918
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9918
uucuguccaa gcccggtt                                                     18


<210> 9919
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9919
uucuguccaa gcccggt                                                      17


<210> 9920
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9920
uucuguccaa gcccgg                                                       16


<210> 9921
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9921
uucuguccaa gcccg                                                        15


<210> 9922
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9922
uucuguccaa gccc                                                         14


<210> 9923
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9923
uucuguccaa gcc                                                          13


<210> 9924
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9924
uucuguccaa gc                                                           12


<210> 9925
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9925
uucuguccaa g                                                            11


<210> 9926
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9926
uucuguccaa                                                              10


<210> 9927
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9927
uucugucca                                                                9


<210> 9928
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9928
uucugucc                                                                 8


<210> 9929
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9929
ucuguccaag cccgguuga                                                    19


<210> 9930
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9930
ucuguccaag cccggutg                                                     18


<210> 9931
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9931
ucuguccaag cccggtt                                                      17


<210> 9932
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9932
ucuguccaag cccggt                                                       16


<210> 9933
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9933
ucuguccaag cccgg                                                        15


<210> 9934
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9934
ucuguccaag cccg                                                         14


<210> 9935
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9935
ucuguccaag ccc                                                          13


<210> 9936
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9936
ucuguccaag cc                                                           12


<210> 9937
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9937
ucuguccaag c                                                            11


<210> 9938
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9938
ucuguccaag                                                              10


<210> 9939
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9939
ucuguccaa                                                                9


<210> 9940
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9940
ucugucca                                                                 8


<210> 9941
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9941
cuguccaagc ccggutg                                                      17


<210> 9942
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9942
cuguccaagc ccggtt                                                       16


<210> 9943
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9943
cuguccaagc ccggt                                                        15


<210> 9944
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9944
cuguccaagc ccgg                                                         14


<210> 9945
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9945
cuguccaagc ccg                                                          13


<210> 9946
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9946
cuguccaagc cc                                                           12


<210> 9947
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9947
cuguccaagc c                                                            11


<210> 9948
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9948
cuguccaagc                                                              10


<210> 9949
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9949
cuguccaag                                                                9


<210> 9950
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9950
cuguccaa                                                                 8


<210> 9951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9951
guucugucca agcccggutg                                                   20


<210> 9952
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9952
guucugucca agcccggtt                                                    19


<210> 9953
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9953
guucugucca agcccggt                                                     18


<210> 9954
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9954
guucugucca agcccgg                                                      17


<210> 9955
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9955
guucugucca agcccg                                                       16


<210> 9956
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9956
guucugucca agccc                                                        15


<210> 9957
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9957
guucugucca agcc                                                         14


<210> 9958
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9958
guucugucca agc                                                          13


<210> 9959
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9959
guucugucca ag                                                           12


<210> 9960
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9960
guucugucca a                                                            11


<210> 9961
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9961
guucugucca                                                              10


<210> 9962
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9962
guucugucc                                                                9


<210> 9963
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9963
guucugtc                                                                 8


<210> 9964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9964
aguucugucc aagcccggtt                                                   20


<210> 9965
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9965
aguucugucc aagcccggt                                                    19


<210> 9966
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9966
aguucugucc aagcccgg                                                     18


<210> 9967
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9967
aguucugucc aagcccg                                                      17


<210> 9968
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9968
aguucugucc aagccc                                                       16


<210> 9969
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9969
aguucugucc aagcc                                                        15


<210> 9970
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9970
aguucugucc aagc                                                         14


<210> 9971
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9971
aguucugucc aag                                                          13


<210> 9972
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9972
aguucugucc aa                                                           12


<210> 9973
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9973
aguucugucc a                                                            11


<210> 9974
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9974
aguucugucc                                                              10


<210> 9975
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9975
aguucugtc                                                                9


<210> 9976
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9976
aguucugt                                                                 8


<210> 9977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9977
aaguucuguc caagcccggt                                                   20


<210> 9978
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9978
aaguucuguc caagcccgg                                                    19


<210> 9979
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9979
aaguucuguc caagcccg                                                     18


<210> 9980
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9980
aaguucuguc caagccc                                                      17


<210> 9981
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9981
aaguucuguc caagcc                                                       16


<210> 9982
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 9982
aaguucuguc caagc                                                        15


<210> 9983
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9983
aaguucuguc caag                                                         14


<210> 9984
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9984
aaguucuguc caa                                                          13


<210> 9985
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9985
aaguucuguc ca                                                           12


<210> 9986
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9986
aaguucuguc c                                                            11


<210> 9987
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9987
aaguucugtc                                                              10


<210> 9988
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 9988
aaguucugt                                                                9


<210> 9989
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 9989
aaguuctg                                                                 8


<210> 9990
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 9990
uaaguucugu ccaagcccgg                                                   20


<210> 9991
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 9991
uaaguucugu ccaagcccg                                                    19


<210> 9992
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 9992
uaaguucugu ccaagccc                                                     18


<210> 9993
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 9993
uaaguucugu ccaagcc                                                      17


<210> 9994
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 9994
uaaguucugu ccaagc                                                       16


<210> 9995
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 9995
uaaguucugu ccaa                                                         14


<210> 9996
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 9996
uaaguucugu cca                                                          13


<210> 9997
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 9997
uaaguucugu cc                                                           12


<210> 9998
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 9998
uaaguucugt c                                                            11


<210> 9999
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 9999
uaaguucugt                                                              10


<210> 10000
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10000
uaaguuctg                                                                9


<210> 10001
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 10001
uaaguuct                                                                 8


<210> 10002
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10002
guaaguucug uccaagcccg                                                   20


<210> 10003
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10003
guaaguucug uccaagccc                                                    19


<210> 10004
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10004
guaaguucug uccaagc                                                      17


<210> 10005
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10005
guaaguucug uccaag                                                       16


<210> 10006
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10006
guaaguucug uccaa                                                        15


<210> 10007
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10007
guaaguucug ucca                                                         14


<210> 10008
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10008
guaaguucug ucc                                                          13


<210> 10009
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10009
guaaguucug tc                                                           12


<210> 10010
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10010
guaaguucug t                                                            11


<210> 10011
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10011
guaaguuctg                                                              10


<210> 10012
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10012
guaaguuct                                                                9


<210> 10013
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 10013
guaagutc                                                                 8


<210> 10014
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10014
gguaaguucu guccaagccc                                                   20


<210> 10015
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10015
gguaaguucu guccaagcc                                                    19


<210> 10016
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10016
gguaaguucu guccaag                                                      17


<210> 10017
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10017
gguaaguucu guccaa                                                       16


<210> 10018
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10018
gguaaguucu gucca                                                        15


<210> 10019
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10019
gguaaguucu gucc                                                         14


<210> 10020
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10020
gguaaguucu gtc                                                          13


<210> 10021
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10021
gguaaguucu gt                                                           12


<210> 10022
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10022
gguaaguuct g                                                            11


<210> 10023
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10023
gguaaguuct                                                              10


<210> 10024
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10024
gguaagutc                                                                9


<210> 10025
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 10025
gguaagtt                                                                 8


<210> 10026
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10026
cgguaaguuc uguccaagcc                                                   20


<210> 10027
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10027
cgguaaguuc uguccaagc                                                    19


<210> 10028
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10028
cgguaaguuc uguccaag                                                     18


<210> 10029
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10029
cgguaaguuc uguccaa                                                      17


<210> 10030
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10030
cgguaaguuc ugucca                                                       16


<210> 10031
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10031
cgguaaguuc ugucc                                                        15


<210> 10032
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10032
cgguaaguuc ugtc                                                         14


<210> 10033
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10033
cgguaaguuc ugt                                                          13


<210> 10034
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10034
cgguaaguuc tg                                                           12


<210> 10035
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10035
cgguaaguuc t                                                            11


<210> 10036
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10036
cgguaagutc                                                              10


<210> 10037
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10037
cgguaagtt                                                                9


<210> 10038
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 10038
cgguaagt                                                                 8


<210> 10039
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10039
ucgguaaguu cuguccaagc                                                   20


<210> 10040
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10040
ucgguaaguu cuguccaag                                                    19


<210> 10041
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10041
ucgguaaguu cuguccaa                                                     18


<210> 10042
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10042
ucgguaaguu cugucca                                                      17


<210> 10043
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10043
ucgguaaguu cugucc                                                       16


<210> 10044
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10044
ucgguaaguu cugtc                                                        15


<210> 10045
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10045
ucgguaaguu cugt                                                         14


<210> 10046
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10046
ucgguaaguu ctg                                                          13


<210> 10047
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10047
ucgguaaguu ct                                                           12


<210> 10048
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10048
ucgguaagut c                                                            11


<210> 10049
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10049
ucgguaagtt                                                              10


<210> 10050
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10050
ucgguaagt                                                                9


<210> 10051
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10051
gucgguaagu ucuguccaag                                                   20


<210> 10052
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10052
gucgguaagu ucuguccaa                                                    19


<210> 10053
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10053
gucgguaagu ucugucca                                                     18


<210> 10054
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10054
gucgguaagu ucugucc                                                      17


<210> 10055
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10055
gucgguaagu ucugtc                                                       16


<210> 10056
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10056
gucgguaagu ucugt                                                        15


<210> 10057
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10057
gucgguaagu uctg                                                         14


<210> 10058
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10058
gucgguaagu uct                                                          13


<210> 10059
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10059
gucgguaagu tc                                                           12


<210> 10060
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10060
gucgguaagt t                                                            11


<210> 10061
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10061
gucgguaagt                                                              10


<210> 10062
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10062
agucgguaag uucuguccaa                                                   20


<210> 10063
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10063
agucgguaag uucugucca                                                    19


<210> 10064
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10064
agucgguaag uucugtc                                                      17


<210> 10065
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10065
agucgguaag uucugt                                                       16


<210> 10066
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10066
agucgguaag uuctg                                                        15


<210> 10067
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10067
agucgguaag uuct                                                         14


<210> 10068
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10068
agucgguaag utc                                                          13


<210> 10069
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10069
agucgguaag tt                                                           12


<210> 10070
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10070
agucgguaag t                                                            11


<210> 10071
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10071
cagucgguaa guucugucca                                                   20


<210> 10072
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10072
cagucgguaa guucugucc                                                    19


<210> 10073
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10073
cagucgguaa guucugtc                                                     18


<210> 10074
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10074
cagucgguaa guucugt                                                      17


<210> 10075
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10075
cagucgguaa guuctg                                                       16


<210> 10076
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10076
cagucgguaa guuct                                                        15


<210> 10077
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10077
cagucgguaa gutc                                                         14


<210> 10078
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10078
cagucgguaa gtt                                                          13


<210> 10079
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10079
cagucgguaa gt                                                           12


<210> 10080
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10080
ccagucggua aguucugucc                                                   20


<210> 10081
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10081
ccagucggua aguucugtc                                                    19


<210> 10082
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10082
ccagucggua aguucugt                                                     18


<210> 10083
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10083
ccagucggua aguuctg                                                      17


<210> 10084
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10084
ccagucggua aguuct                                                       16


<210> 10085
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10085
ccagucggua agutc                                                        15


<210> 10086
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10086
ccagucggua agtt                                                         14


<210> 10087
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10087
ccagucggua agt                                                          13


<210> 10088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10088
gccagucggu aaguucugtc                                                   20


<210> 10089
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10089
gccagucggu aaguucugt                                                    19


<210> 10090
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10090
gccagucggu aaguuctg                                                     18


<210> 10091
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10091
gccagucggu aaguuct                                                      17


<210> 10092
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10092
gccagucggu aagutc                                                       16


<210> 10093
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10093
gccagucggu aagtt                                                        15


<210> 10094
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10094
gccagucggu aagt                                                         14


<210> 10095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10095
ucaaggaaga uggcauuuct                                                   20


<210> 10096
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 10096
ucaaggaaga uggcauuucu ag                                                22


<210> 10097
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10097
ucaaggaaga uggcat                                                       16


<210> 10098
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10098
gaagauggca uuuct                                                        15


<210> 10099
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 10099
ucaaggaaga uggcauuuct a                                                 21


<210> 10100
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10100
ucaaggaaga uggcauutc                                                    19


<210> 10101
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10101
ucaaggaaga uggcautt                                                     18


<210> 10102
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10102
ucaaggaaga uggcatt                                                      17


<210> 10103
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10103
ucaaggaaga uggca                                                        15


<210> 10104
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10104
ucaaggaaga uggc                                                         14


<210> 10105
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10105
ucaaggaaga ugg                                                          13


<210> 10106
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10106
ucaaggaaga tg                                                           12


<210> 10107
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10107
ucaaggaaga t                                                            11


<210> 10108
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10108
ucaaggaaga                                                              10


<210> 10109
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10109
ucaaggaag                                                                9


<210> 10110
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 10110
caaggaagau ggcauuucua g                                                 21


<210> 10111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10111
caaggaagau ggcauuucta                                                   20


<210> 10112
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10112
caaggaagau ggcauuuct                                                    19


<210> 10113
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10113
caaggaagau ggcauutc                                                     18


<210> 10114
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10114
caaggaagau ggcautt                                                      17


<210> 10115
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10115
caaggaagau ggcatt                                                       16


<210> 10116
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10116
caaggaagau ggcat                                                        15


<210> 10117
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10117
caaggaagau ggca                                                         14


<210> 10118
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10118
caaggaagau ggc                                                          13


<210> 10119
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10119
caaggaagau gg                                                           12


<210> 10120
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10120
caaggaagat g                                                            11


<210> 10121
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10121
caaggaagat                                                              10


<210> 10122
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10122
caaggaaga                                                                9


<210> 10123
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 10123
caaggaag                                                                 8


<210> 10124
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10124
aaggaagaug gcauuucuag                                                   20


<210> 10125
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10125
aaggaagaug gcauuucta                                                    19


<210> 10126
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10126
aaggaagaug gcauuuct                                                     18


<210> 10127
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10127
aaggaagaug gcauutc                                                      17


<210> 10128
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10128
aaggaagaug gcautt                                                       16


<210> 10129
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10129
aaggaagaug gcatt                                                        15


<210> 10130
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10130
aaggaagaug gcat                                                         14


<210> 10131
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10131
aaggaagaug gca                                                          13


<210> 10132
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10132
aaggaagaug gc                                                           12


<210> 10133
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10133
aaggaagaug g                                                            11


<210> 10134
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10134
aaggaagatg                                                              10


<210> 10135
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10135
aaggaagat                                                                9


<210> 10136
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 10136
aaggaaga                                                                 8


<210> 10137
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10137
aggaagaugg cauuucuag                                                    19


<210> 10138
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10138
aggaagaugg cauuucta                                                     18


<210> 10139
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10139
aggaagaugg cauuuct                                                      17


<210> 10140
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10140
aggaagaugg cauutc                                                       16


<210> 10141
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10141
aggaagaugg cautt                                                        15


<210> 10142
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10142
aggaagaugg catt                                                         14


<210> 10143
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10143
aggaagaugg cat                                                          13


<210> 10144
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10144
aggaagaugg ca                                                           12


<210> 10145
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10145
aggaagaugg                                                              10


<210> 10146
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10146
aggaagatg                                                                9


<210> 10147
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 10147
aggaagat                                                                 8


<210> 10148
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10148
ggaagauggc auuucuag                                                     18


<210> 10149
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10149
ggaagauggc auuucta                                                      17


<210> 10150
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10150
ggaagauggc auuuct                                                       16


<210> 10151
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10151
ggaagauggc auutc                                                        15


<210> 10152
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10152
ggaagauggc autt                                                         14


<210> 10153
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10153
ggaagauggc att                                                          13


<210> 10154
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10154
ggaagauggc at                                                           12


<210> 10155
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10155
ggaagauggc a                                                            11


<210> 10156
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10156
ggaagauggc                                                              10


<210> 10157
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 10157
ggaagatg                                                                 8


<210> 10158
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10158
gaagauggca uuucuag                                                      17


<210> 10159
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10159
gaagauggca uuucta                                                       16


<210> 10160
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10160
gaagauggca uutc                                                         14


<210> 10161
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10161
gaagauggca utt                                                          13


<210> 10162
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10162
gaagauggca tt                                                           12


<210> 10163
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10163
gaagauggca t                                                            11


<210> 10164
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10164
gaagauggca                                                              10


<210> 10165
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10165
gaagauggc                                                                9


<210> 10166
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 10166
gaagaugg                                                                 8


<210> 10167
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10167
aagauggcau uucuag                                                       16


<210> 10168
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10168
aagauggcau uucta                                                        15


<210> 10169
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10169
aagauggcau uuct                                                         14


<210> 10170
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10170
aagauggcau utc                                                          13


<210> 10171
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10171
aagauggcau tt                                                           12


<210> 10172
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10172
aagauggcat t                                                            11


<210> 10173
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10173
aagauggcat                                                              10


<210> 10174
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10174
aagauggca                                                                9


<210> 10175
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 10175
aagauggc                                                                 8


<210> 10176
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10176
agauggcauu ucuag                                                        15


<210> 10177
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10177
agauggcauu ucta                                                         14


<210> 10178
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10178
agauggcauu uct                                                          13


<210> 10179
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10179
agauggcauu tc                                                           12


<210> 10180
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10180
agauggcaut t                                                            11


<210> 10181
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10181
agauggcatt                                                              10


<210> 10182
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 10182
agauggcat                                                                9


<210> 10183
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 10183
agauggca                                                                 8


<210> 10184
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 10184
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 10185
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 10185
cuccaacauc aaggaagaug gcauuucta                                         29


<210> 10186
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 10186
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 10187
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 10187
cuccaacauc aaggaagaug gcauutc                                           27


<210> 10188
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 10188
cuccaacauc aaggaagaug gcautt                                            26


<210> 10189
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 10189
cuccaacauc aaggaagaug gcatt                                             25


<210> 10190
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 10190
cuccaacauc aaggaagaug gcat                                              24


<210> 10191
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 10191
cuccaacauc aaggaagaug gca                                               23


<210> 10192
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 10192
cuccaacauc aaggaagaug gc                                                22


<210> 10193
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 10193
cuccaacauc aaggaagaug g                                                 21


<210> 10194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10194
cuccaacauc aaggaagatg                                                   20


<210> 10195
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10195
cuccaacauc aaggaagat                                                    19


<210> 10196
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10196
cuccaacauc aaggaaga                                                     18


<210> 10197
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10197
cuccaacauc aaggaag                                                      17


<210> 10198
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 10198
uccaacauca aggaagaugg cauuucuag                                         29


<210> 10199
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 10199
uccaacauca aggaagaugg cauuucta                                          28


<210> 10200
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 10200
uccaacauca aggaagaugg cauuuct                                           27


<210> 10201
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 10201
uccaacauca aggaagaugg cauutc                                            26


<210> 10202
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 10202
uccaacauca aggaagaugg cautt                                             25


<210> 10203
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 10203
uccaacauca aggaagaugg catt                                              24


<210> 10204
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 10204
uccaacauca aggaagaugg cat                                               23


<210> 10205
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 10205
uccaacauca aggaagaugg ca                                                22


<210> 10206
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 10206
uccaacauca aggaagaugg c                                                 21


<210> 10207
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10207
uccaacauca aggaagaugg                                                   20


<210> 10208
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10208
uccaacauca aggaagatg                                                    19


<210> 10209
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10209
uccaacauca aggaagat                                                     18


<210> 10210
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10210
uccaacauca aggaaga                                                      17


<210> 10211
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10211
uccaacauca aggaag                                                       16


<210> 10212
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 10212
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 10213
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 10213
ccaacaucaa ggaagauggc auuucta                                           27


<210> 10214
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 10214
ccaacaucaa ggaagauggc auuuct                                            26


<210> 10215
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 10215
ccaacaucaa ggaagauggc auutc                                             25


<210> 10216
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 10216
ccaacaucaa ggaagauggc autt                                              24


<210> 10217
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 10217
ccaacaucaa ggaagauggc att                                               23


<210> 10218
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 10218
ccaacaucaa ggaagauggc at                                                22


<210> 10219
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 10219
ccaacaucaa ggaagauggc a                                                 21


<210> 10220
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10220
ccaacaucaa ggaagauggc                                                   20


<210> 10221
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10221
ccaacaucaa ggaagaugg                                                    19


<210> 10222
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10222
ccaacaucaa ggaagatg                                                     18


<210> 10223
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10223
ccaacaucaa ggaagat                                                      17


<210> 10224
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10224
ccaacaucaa ggaaga                                                       16


<210> 10225
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10225
ccaacaucaa ggaag                                                        15


<210> 10226
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 10226
caacaucaag gaagauggca uuucuag                                           27


<210> 10227
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 10227
caacaucaag gaagauggca uuucta                                            26


<210> 10228
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 10228
caacaucaag gaagauggca uuuct                                             25


<210> 10229
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 10229
caacaucaag gaagauggca uutc                                              24


<210> 10230
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 10230
caacaucaag gaagauggca utt                                               23


<210> 10231
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 10231
caacaucaag gaagauggca tt                                                22


<210> 10232
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 10232
caacaucaag gaagauggca t                                                 21


<210> 10233
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10233
caacaucaag gaagauggca                                                   20


<210> 10234
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10234
caacaucaag gaagauggc                                                    19


<210> 10235
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10235
caacaucaag gaagaugg                                                     18


<210> 10236
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10236
caacaucaag gaagatg                                                      17


<210> 10237
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10237
caacaucaag gaagat                                                       16


<210> 10238
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10238
caacaucaag gaaga                                                        15


<210> 10239
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10239
caacaucaag gaag                                                         14


<210> 10240
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 10240
aacaucaagg aagauggcau uucuag                                            26


<210> 10241
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 10241
aacaucaagg aagauggcau uucta                                             25


<210> 10242
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 10242
aacaucaagg aagauggcau uuct                                              24


<210> 10243
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 10243
aacaucaagg aagauggcau utc                                               23


<210> 10244
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 10244
aacaucaagg aagauggcau tt                                                22


<210> 10245
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 10245
aacaucaagg aagauggcat t                                                 21


<210> 10246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10246
aacaucaagg aagauggcat                                                   20


<210> 10247
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10247
aacaucaagg aagauggca                                                    19


<210> 10248
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10248
aacaucaagg aagauggc                                                     18


<210> 10249
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10249
aacaucaagg aagaugg                                                      17


<210> 10250
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10250
aacaucaagg aagatg                                                       16


<210> 10251
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10251
aacaucaagg aagat                                                        15


<210> 10252
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10252
aacaucaagg aaga                                                         14


<210> 10253
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10253
aacaucaagg aag                                                          13


<210> 10254
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 10254
acaucaagga agauggcauu ucuag                                             25


<210> 10255
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 10255
acaucaagga agauggcauu ucta                                              24


<210> 10256
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 10256
acaucaagga agauggcauu uct                                               23


<210> 10257
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 10257
acaucaagga agauggcauu tc                                                22


<210> 10258
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 10258
acaucaagga agauggcaut t                                                 21


<210> 10259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10259
acaucaagga agauggcatt                                                   20


<210> 10260
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10260
acaucaagga agauggcat                                                    19


<210> 10261
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10261
acaucaagga agauggca                                                     18


<210> 10262
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10262
acaucaagga agauggc                                                      17


<210> 10263
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10263
acaucaagga agaugg                                                       16


<210> 10264
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10264
acaucaagga agatg                                                        15


<210> 10265
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10265
acaucaagga agat                                                         14


<210> 10266
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10266
acaucaagga aga                                                          13


<210> 10267
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10267
acaucaagga ag                                                           12


<210> 10268
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 10268
caucaaggaa gauggcauuu cuag                                              24


<210> 10269
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 10269
caucaaggaa gauggcauuu cta                                               23


<210> 10270
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 10270
caucaaggaa gauggcauuu ct                                                22


<210> 10271
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 10271
caucaaggaa gauggcauut c                                                 21


<210> 10272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10272
caucaaggaa gauggcautt                                                   20


<210> 10273
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10273
caucaaggaa gauggcatt                                                    19


<210> 10274
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10274
caucaaggaa gauggcat                                                     18


<210> 10275
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10275
caucaaggaa gauggca                                                      17


<210> 10276
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10276
caucaaggaa gauggc                                                       16


<210> 10277
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10277
caucaaggaa gaugg                                                        15


<210> 10278
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10278
caucaaggaa gatg                                                         14


<210> 10279
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10279
caucaaggaa gat                                                          13


<210> 10280
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10280
caucaaggaa ga                                                           12


<210> 10281
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10281
caucaaggaa g                                                            11


<210> 10282
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 10282
aucaaggaag auggcauuuc uag                                               23


<210> 10283
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 10283
aucaaggaag auggcauuuc ta                                                22


<210> 10284
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 10284
aucaaggaag auggcauuuc t                                                 21


<210> 10285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10285
aucaaggaag auggcauutc                                                   20


<210> 10286
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10286
aucaaggaag auggcautt                                                    19


<210> 10287
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10287
aucaaggaag auggcatt                                                     18


<210> 10288
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10288
aucaaggaag auggcat                                                      17


<210> 10289
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 10289
aucaaggaag auggca                                                       16


<210> 10290
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 10290
aucaaggaag auggc                                                        15


<210> 10291
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 10291
aucaaggaag augg                                                         14


<210> 10292
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 10292
aucaaggaag atg                                                          13


<210> 10293
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 10293
aucaaggaag at                                                           12


<210> 10294
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 10294
aucaaggaag a                                                            11


<210> 10295
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 10295
aucaaggaag                                                              10


<210> 10296
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 10296
ccagagcagg uaccuccaac atc                                               23


<210> 10297
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10297
ccagagcagg uaccucca                                                     18


<210> 10298
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 10298
ccucugugau uuuauaacuu gat                                               23


<210> 10299
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10299
ucacccacca ucaccct                                                      17


<210> 10300
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 10300
ugauauccuc aaggucaccc                                                   20


<210> 10301
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 10301
cugcuugaug aucaucucgu tg                                                22


<210> 10302
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 10302
cugcuugaug aucauctc                                                     18


<210> 10303
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 10303
guuuccuuag uaaccacag                                                    19


<210> 10304
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 10304
guuuccuuag uaaccac                                                      17


<210> 10305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10305
ucaaggaaga uggcauuuct                                                   20


<210> 10306
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10306
ucaaggaaga uggcauuucu ag                                                22


<210> 10307
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10307
gguaaguucu guccaagc                                                     18


<210> 10308
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10308
guaaguucug uccaagcc                                                     18


<210> 10309
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10309
agucgguaag uucugucc                                                     18


<210> 10310
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10310
cuguccaagc ccgguuga                                                     18


<210> 10311
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10311
uaaguucugu ccaag                                                        15


<210> 10312
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10312
uucuguccaa gcccgguuga                                                   20


<210> 10313
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10313
uucuguccaa gcccggutg                                                    19


<210> 10314
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10314
uucuguccaa gcccggtt                                                     18


<210> 10315
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10315
uucuguccaa gcccggt                                                      17


<210> 10316
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10316
uucuguccaa gcccgg                                                       16


<210> 10317
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10317
uucuguccaa gcccg                                                        15


<210> 10318
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10318
uucuguccaa gccc                                                         14


<210> 10319
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10319
uucuguccaa gcc                                                          13


<210> 10320
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10320
uucuguccaa gc                                                           12


<210> 10321
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10321
uucuguccaa g                                                            11


<210> 10322
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10322
uucuguccaa                                                              10


<210> 10323
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10323
uucugucca                                                                9


<210> 10324
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10324
uucugucc                                                                 8


<210> 10325
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10325
ucuguccaag cccgguuga                                                    19


<210> 10326
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10326
ucuguccaag cccggutg                                                     18


<210> 10327
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10327
ucuguccaag cccggtt                                                      17


<210> 10328
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10328
ucuguccaag cccggt                                                       16


<210> 10329
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10329
ucuguccaag cccgg                                                        15


<210> 10330
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10330
ucuguccaag cccg                                                         14


<210> 10331
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10331
ucuguccaag ccc                                                          13


<210> 10332
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10332
ucuguccaag cc                                                           12


<210> 10333
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10333
ucuguccaag c                                                            11


<210> 10334
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10334
ucuguccaag                                                              10


<210> 10335
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10335
ucuguccaa                                                                9


<210> 10336
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10336
ucugucca                                                                 8


<210> 10337
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10337
cuguccaagc ccggutg                                                      17


<210> 10338
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10338
cuguccaagc ccggtt                                                       16


<210> 10339
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10339
cuguccaagc ccggt                                                        15


<210> 10340
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10340
cuguccaagc ccgg                                                         14


<210> 10341
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10341
cuguccaagc ccg                                                          13


<210> 10342
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10342
cuguccaagc cc                                                           12


<210> 10343
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10343
cuguccaagc c                                                            11


<210> 10344
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10344
cuguccaagc                                                              10


<210> 10345
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10345
cuguccaag                                                                9


<210> 10346
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10346
cuguccaa                                                                 8


<210> 10347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10347
guucugucca agcccggutg                                                   20


<210> 10348
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10348
guucugucca agcccggtt                                                    19


<210> 10349
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10349
guucugucca agcccggt                                                     18


<210> 10350
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10350
guucugucca agcccgg                                                      17


<210> 10351
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10351
guucugucca agcccg                                                       16


<210> 10352
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10352
guucugucca agccc                                                        15


<210> 10353
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10353
guucugucca agcc                                                         14


<210> 10354
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10354
guucugucca agc                                                          13


<210> 10355
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10355
guucugucca ag                                                           12


<210> 10356
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10356
guucugucca a                                                            11


<210> 10357
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10357
guucugucca                                                              10


<210> 10358
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10358
guucugucc                                                                9


<210> 10359
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10359
guucugtc                                                                 8


<210> 10360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10360
aguucugucc aagcccggtt                                                   20


<210> 10361
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10361
aguucugucc aagcccggt                                                    19


<210> 10362
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10362
aguucugucc aagcccgg                                                     18


<210> 10363
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10363
aguucugucc aagcccg                                                      17


<210> 10364
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10364
aguucugucc aagccc                                                       16


<210> 10365
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10365
aguucugucc aagcc                                                        15


<210> 10366
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10366
aguucugucc aagc                                                         14


<210> 10367
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10367
aguucugucc aag                                                          13


<210> 10368
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10368
aguucugucc aa                                                           12


<210> 10369
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10369
aguucugucc a                                                            11


<210> 10370
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10370
aguucugucc                                                              10


<210> 10371
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10371
aguucugtc                                                                9


<210> 10372
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10372
aguucugt                                                                 8


<210> 10373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10373
aaguucuguc caagcccggt                                                   20


<210> 10374
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10374
aaguucuguc caagcccgg                                                    19


<210> 10375
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10375
aaguucuguc caagcccg                                                     18


<210> 10376
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10376
aaguucuguc caagccc                                                      17


<210> 10377
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10377
aaguucuguc caagcc                                                       16


<210> 10378
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10378
aaguucuguc caagc                                                        15


<210> 10379
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10379
aaguucuguc caag                                                         14


<210> 10380
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10380
aaguucuguc caa                                                          13


<210> 10381
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10381
aaguucuguc ca                                                           12


<210> 10382
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10382
aaguucuguc c                                                            11


<210> 10383
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10383
aaguucugtc                                                              10


<210> 10384
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10384
aaguucugt                                                                9


<210> 10385
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10385
aaguuctg                                                                 8


<210> 10386
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10386
uaaguucugu ccaagcccgg                                                   20


<210> 10387
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10387
uaaguucugu ccaagcccg                                                    19


<210> 10388
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10388
uaaguucugu ccaagccc                                                     18


<210> 10389
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10389
uaaguucugu ccaagcc                                                      17


<210> 10390
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10390
uaaguucugu ccaagc                                                       16


<210> 10391
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10391
uaaguucugu ccaa                                                         14


<210> 10392
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10392
uaaguucugu cca                                                          13


<210> 10393
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10393
uaaguucugu cc                                                           12


<210> 10394
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10394
uaaguucugt c                                                            11


<210> 10395
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10395
uaaguucugt                                                              10


<210> 10396
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10396
uaaguuctg                                                                9


<210> 10397
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10397
uaaguuct                                                                 8


<210> 10398
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10398
guaaguucug uccaagcccg                                                   20


<210> 10399
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10399
guaaguucug uccaagccc                                                    19


<210> 10400
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10400
guaaguucug uccaagc                                                      17


<210> 10401
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10401
guaaguucug uccaag                                                       16


<210> 10402
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10402
guaaguucug uccaa                                                        15


<210> 10403
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10403
guaaguucug ucca                                                         14


<210> 10404
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10404
guaaguucug ucc                                                          13


<210> 10405
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10405
guaaguucug tc                                                           12


<210> 10406
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10406
guaaguucug t                                                            11


<210> 10407
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10407
guaaguuctg                                                              10


<210> 10408
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10408
guaaguuct                                                                9


<210> 10409
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10409
guaagutc                                                                 8


<210> 10410
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10410
gguaaguucu guccaagccc                                                   20


<210> 10411
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10411
gguaaguucu guccaagcc                                                    19


<210> 10412
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10412
gguaaguucu guccaag                                                      17


<210> 10413
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10413
gguaaguucu guccaa                                                       16


<210> 10414
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10414
gguaaguucu gucca                                                        15


<210> 10415
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10415
gguaaguucu gucc                                                         14


<210> 10416
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10416
gguaaguucu gtc                                                          13


<210> 10417
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10417
gguaaguucu gt                                                           12


<210> 10418
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10418
gguaaguuct g                                                            11


<210> 10419
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10419
gguaaguuct                                                              10


<210> 10420
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10420
gguaagutc                                                                9


<210> 10421
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10421
gguaagtt                                                                 8


<210> 10422
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10422
cgguaaguuc uguccaagcc                                                   20


<210> 10423
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10423
cgguaaguuc uguccaagc                                                    19


<210> 10424
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10424
cgguaaguuc uguccaag                                                     18


<210> 10425
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10425
cgguaaguuc uguccaa                                                      17


<210> 10426
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10426
cgguaaguuc ugucca                                                       16


<210> 10427
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10427
cgguaaguuc ugucc                                                        15


<210> 10428
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10428
cgguaaguuc ugtc                                                         14


<210> 10429
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10429
cgguaaguuc ugt                                                          13


<210> 10430
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10430
cgguaaguuc tg                                                           12


<210> 10431
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10431
cgguaaguuc t                                                            11


<210> 10432
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10432
cgguaagutc                                                              10


<210> 10433
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10433
cgguaagtt                                                                9


<210> 10434
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10434
cgguaagt                                                                 8


<210> 10435
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10435
ucgguaaguu cuguccaagc                                                   20


<210> 10436
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10436
ucgguaaguu cuguccaag                                                    19


<210> 10437
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10437
ucgguaaguu cuguccaa                                                     18


<210> 10438
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10438
ucgguaaguu cugucca                                                      17


<210> 10439
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10439
ucgguaaguu cugucc                                                       16


<210> 10440
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10440
ucgguaaguu cugtc                                                        15


<210> 10441
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10441
ucgguaaguu cugt                                                         14


<210> 10442
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10442
ucgguaaguu ctg                                                          13


<210> 10443
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10443
ucgguaaguu ct                                                           12


<210> 10444
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10444
ucgguaagut c                                                            11


<210> 10445
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10445
ucgguaagtt                                                              10


<210> 10446
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10446
ucgguaagt                                                                9


<210> 10447
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10447
gucgguaagu ucuguccaag                                                   20


<210> 10448
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10448
gucgguaagu ucuguccaa                                                    19


<210> 10449
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10449
gucgguaagu ucugucca                                                     18


<210> 10450
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10450
gucgguaagu ucugucc                                                      17


<210> 10451
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10451
gucgguaagu ucugtc                                                       16


<210> 10452
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10452
gucgguaagu ucugt                                                        15


<210> 10453
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10453
gucgguaagu uctg                                                         14


<210> 10454
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10454
gucgguaagu uct                                                          13


<210> 10455
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10455
gucgguaagu tc                                                           12


<210> 10456
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10456
gucgguaagt t                                                            11


<210> 10457
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10457
gucgguaagt                                                              10


<210> 10458
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10458
agucgguaag uucuguccaa                                                   20


<210> 10459
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10459
agucgguaag uucugucca                                                    19


<210> 10460
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10460
agucgguaag uucugtc                                                      17


<210> 10461
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10461
agucgguaag uucugt                                                       16


<210> 10462
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10462
agucgguaag uuctg                                                        15


<210> 10463
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10463
agucgguaag uuct                                                         14


<210> 10464
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10464
agucgguaag utc                                                          13


<210> 10465
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10465
agucgguaag tt                                                           12


<210> 10466
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10466
agucgguaag t                                                            11


<210> 10467
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10467
cagucgguaa guucugucca                                                   20


<210> 10468
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10468
cagucgguaa guucugucc                                                    19


<210> 10469
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10469
cagucgguaa guucugtc                                                     18


<210> 10470
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10470
cagucgguaa guucugt                                                      17


<210> 10471
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10471
cagucgguaa guuctg                                                       16


<210> 10472
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10472
cagucgguaa guuct                                                        15


<210> 10473
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10473
cagucgguaa gutc                                                         14


<210> 10474
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10474
cagucgguaa gtt                                                          13


<210> 10475
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10475
cagucgguaa gt                                                           12


<210> 10476
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10476
ccagucggua aguucugucc                                                   20


<210> 10477
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10477
ccagucggua aguucugtc                                                    19


<210> 10478
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10478
ccagucggua aguucugt                                                     18


<210> 10479
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10479
ccagucggua aguuctg                                                      17


<210> 10480
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10480
ccagucggua aguuct                                                       16


<210> 10481
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10481
ccagucggua agutc                                                        15


<210> 10482
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10482
ccagucggua agtt                                                         14


<210> 10483
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10483
ccagucggua agt                                                          13


<210> 10484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10484
gccagucggu aaguucugtc                                                   20


<210> 10485
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10485
gccagucggu aaguucugt                                                    19


<210> 10486
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10486
gccagucggu aaguuctg                                                     18


<210> 10487
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10487
gccagucggu aaguuct                                                      17


<210> 10488
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10488
gccagucggu aagutc                                                       16


<210> 10489
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10489
gccagucggu aagtt                                                        15


<210> 10490
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10490
gccagucggu aagt                                                         14


<210> 10491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10491
ucaaggaaga uggcauuuct                                                   20


<210> 10492
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10492
ucaaggaaga uggcauuucu ag                                                22


<210> 10493
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10493
ucaaggaaga uggcat                                                       16


<210> 10494
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10494
gaagauggca uuuct                                                        15


<210> 10495
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10495
ucaaggaaga uggcauuuct a                                                 21


<210> 10496
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10496
ucaaggaaga uggcauutc                                                    19


<210> 10497
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10497
ucaaggaaga uggcautt                                                     18


<210> 10498
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10498
ucaaggaaga uggcatt                                                      17


<210> 10499
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10499
ucaaggaaga uggca                                                        15


<210> 10500
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10500
ucaaggaaga uggc                                                         14


<210> 10501
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10501
ucaaggaaga ugg                                                          13


<210> 10502
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10502
ucaaggaaga tg                                                           12


<210> 10503
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10503
ucaaggaaga t                                                            11


<210> 10504
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10504
ucaaggaaga                                                              10


<210> 10505
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10505
ucaaggaag                                                                9


<210> 10506
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10506
caaggaagau ggcauuucua g                                                 21


<210> 10507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10507
caaggaagau ggcauuucta                                                   20


<210> 10508
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10508
caaggaagau ggcauuuct                                                    19


<210> 10509
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10509
caaggaagau ggcauutc                                                     18


<210> 10510
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10510
caaggaagau ggcautt                                                      17


<210> 10511
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10511
caaggaagau ggcatt                                                       16


<210> 10512
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10512
caaggaagau ggcat                                                        15


<210> 10513
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10513
caaggaagau ggca                                                         14


<210> 10514
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10514
caaggaagau ggc                                                          13


<210> 10515
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10515
caaggaagau gg                                                           12


<210> 10516
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10516
caaggaagat g                                                            11


<210> 10517
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10517
caaggaagat                                                              10


<210> 10518
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10518
caaggaaga                                                                9


<210> 10519
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10519
caaggaag                                                                 8


<210> 10520
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10520
aaggaagaug gcauuucuag                                                   20


<210> 10521
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10521
aaggaagaug gcauuucta                                                    19


<210> 10522
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10522
aaggaagaug gcauuuct                                                     18


<210> 10523
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10523
aaggaagaug gcauutc                                                      17


<210> 10524
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10524
aaggaagaug gcautt                                                       16


<210> 10525
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10525
aaggaagaug gcatt                                                        15


<210> 10526
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10526
aaggaagaug gcat                                                         14


<210> 10527
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10527
aaggaagaug gca                                                          13


<210> 10528
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10528
aaggaagaug gc                                                           12


<210> 10529
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10529
aaggaagaug g                                                            11


<210> 10530
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10530
aaggaagatg                                                              10


<210> 10531
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10531
aaggaagat                                                                9


<210> 10532
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10532
aaggaaga                                                                 8


<210> 10533
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10533
aggaagaugg cauuucuag                                                    19


<210> 10534
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10534
aggaagaugg cauuucta                                                     18


<210> 10535
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10535
aggaagaugg cauuuct                                                      17


<210> 10536
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10536
aggaagaugg cauutc                                                       16


<210> 10537
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10537
aggaagaugg cautt                                                        15


<210> 10538
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10538
aggaagaugg catt                                                         14


<210> 10539
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10539
aggaagaugg cat                                                          13


<210> 10540
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10540
aggaagaugg ca                                                           12


<210> 10541
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10541
aggaagaugg                                                              10


<210> 10542
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10542
aggaagatg                                                                9


<210> 10543
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10543
aggaagat                                                                 8


<210> 10544
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10544
ggaagauggc auuucuag                                                     18


<210> 10545
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10545
ggaagauggc auuucta                                                      17


<210> 10546
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10546
ggaagauggc auuuct                                                       16


<210> 10547
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10547
ggaagauggc auutc                                                        15


<210> 10548
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10548
ggaagauggc autt                                                         14


<210> 10549
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10549
ggaagauggc att                                                          13


<210> 10550
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10550
ggaagauggc at                                                           12


<210> 10551
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10551
ggaagauggc a                                                            11


<210> 10552
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10552
ggaagauggc                                                              10


<210> 10553
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10553
ggaagatg                                                                 8


<210> 10554
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10554
gaagauggca uuucuag                                                      17


<210> 10555
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10555
gaagauggca uuucta                                                       16


<210> 10556
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10556
gaagauggca uutc                                                         14


<210> 10557
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10557
gaagauggca utt                                                          13


<210> 10558
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10558
gaagauggca tt                                                           12


<210> 10559
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10559
gaagauggca t                                                            11


<210> 10560
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10560
gaagauggca                                                              10


<210> 10561
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10561
gaagauggc                                                                9


<210> 10562
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10562
gaagaugg                                                                 8


<210> 10563
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10563
aagauggcau uucuag                                                       16


<210> 10564
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10564
aagauggcau uucta                                                        15


<210> 10565
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10565
aagauggcau uuct                                                         14


<210> 10566
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10566
aagauggcau utc                                                          13


<210> 10567
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10567
aagauggcau tt                                                           12


<210> 10568
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10568
aagauggcat t                                                            11


<210> 10569
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10569
aagauggcat                                                              10


<210> 10570
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10570
aagauggca                                                                9


<210> 10571
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10571
aagauggc                                                                 8


<210> 10572
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10572
agauggcauu ucuag                                                        15


<210> 10573
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10573
agauggcauu ucta                                                         14


<210> 10574
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10574
agauggcauu uct                                                          13


<210> 10575
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10575
agauggcauu tc                                                           12


<210> 10576
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10576
agauggcaut t                                                            11


<210> 10577
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10577
agauggcatt                                                              10


<210> 10578
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10578
agauggcat                                                                9


<210> 10579
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10579
agauggca                                                                 8


<210> 10580
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10580
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 10581
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10581
cuccaacauc aaggaagaug gcauuucta                                         29


<210> 10582
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10582
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 10583
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10583
cuccaacauc aaggaagaug gcauutc                                           27


<210> 10584
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10584
cuccaacauc aaggaagaug gcautt                                            26


<210> 10585
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10585
cuccaacauc aaggaagaug gcatt                                             25


<210> 10586
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10586
cuccaacauc aaggaagaug gcat                                              24


<210> 10587
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10587
cuccaacauc aaggaagaug gca                                               23


<210> 10588
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10588
cuccaacauc aaggaagaug gc                                                22


<210> 10589
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10589
cuccaacauc aaggaagaug g                                                 21


<210> 10590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10590
cuccaacauc aaggaagatg                                                   20


<210> 10591
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10591
cuccaacauc aaggaagat                                                    19


<210> 10592
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10592
cuccaacauc aaggaaga                                                     18


<210> 10593
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10593
cuccaacauc aaggaag                                                      17


<210> 10594
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10594
uccaacauca aggaagaugg cauuucuag                                         29


<210> 10595
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10595
uccaacauca aggaagaugg cauuucta                                          28


<210> 10596
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10596
uccaacauca aggaagaugg cauuuct                                           27


<210> 10597
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10597
uccaacauca aggaagaugg cauutc                                            26


<210> 10598
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10598
uccaacauca aggaagaugg cautt                                             25


<210> 10599
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10599
uccaacauca aggaagaugg catt                                              24


<210> 10600
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10600
uccaacauca aggaagaugg cat                                               23


<210> 10601
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10601
uccaacauca aggaagaugg ca                                                22


<210> 10602
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10602
uccaacauca aggaagaugg c                                                 21


<210> 10603
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10603
uccaacauca aggaagaugg                                                   20


<210> 10604
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10604
uccaacauca aggaagatg                                                    19


<210> 10605
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10605
uccaacauca aggaagat                                                     18


<210> 10606
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10606
uccaacauca aggaaga                                                      17


<210> 10607
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10607
uccaacauca aggaag                                                       16


<210> 10608
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10608
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 10609
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10609
ccaacaucaa ggaagauggc auuucta                                           27


<210> 10610
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10610
ccaacaucaa ggaagauggc auuuct                                            26


<210> 10611
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10611
ccaacaucaa ggaagauggc auutc                                             25


<210> 10612
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10612
ccaacaucaa ggaagauggc autt                                              24


<210> 10613
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10613
ccaacaucaa ggaagauggc att                                               23


<210> 10614
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10614
ccaacaucaa ggaagauggc at                                                22


<210> 10615
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10615
ccaacaucaa ggaagauggc a                                                 21


<210> 10616
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10616
ccaacaucaa ggaagauggc                                                   20


<210> 10617
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10617
ccaacaucaa ggaagaugg                                                    19


<210> 10618
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10618
ccaacaucaa ggaagatg                                                     18


<210> 10619
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10619
ccaacaucaa ggaagat                                                      17


<210> 10620
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10620
ccaacaucaa ggaaga                                                       16


<210> 10621
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10621
ccaacaucaa ggaag                                                        15


<210> 10622
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10622
caacaucaag gaagauggca uuucuag                                           27


<210> 10623
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10623
caacaucaag gaagauggca uuucta                                            26


<210> 10624
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10624
caacaucaag gaagauggca uuuct                                             25


<210> 10625
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10625
caacaucaag gaagauggca uutc                                              24


<210> 10626
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10626
caacaucaag gaagauggca utt                                               23


<210> 10627
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10627
caacaucaag gaagauggca tt                                                22


<210> 10628
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10628
caacaucaag gaagauggca t                                                 21


<210> 10629
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10629
caacaucaag gaagauggca                                                   20


<210> 10630
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10630
caacaucaag gaagauggc                                                    19


<210> 10631
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10631
caacaucaag gaagaugg                                                     18


<210> 10632
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10632
caacaucaag gaagatg                                                      17


<210> 10633
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10633
caacaucaag gaagat                                                       16


<210> 10634
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10634
caacaucaag gaaga                                                        15


<210> 10635
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10635
caacaucaag gaag                                                         14


<210> 10636
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10636
aacaucaagg aagauggcau uucuag                                            26


<210> 10637
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10637
aacaucaagg aagauggcau uucta                                             25


<210> 10638
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10638
aacaucaagg aagauggcau uuct                                              24


<210> 10639
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10639
aacaucaagg aagauggcau utc                                               23


<210> 10640
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10640
aacaucaagg aagauggcau tt                                                22


<210> 10641
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10641
aacaucaagg aagauggcat t                                                 21


<210> 10642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10642
aacaucaagg aagauggcat                                                   20


<210> 10643
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10643
aacaucaagg aagauggca                                                    19


<210> 10644
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10644
aacaucaagg aagauggc                                                     18


<210> 10645
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10645
aacaucaagg aagaugg                                                      17


<210> 10646
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10646
aacaucaagg aagatg                                                       16


<210> 10647
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10647
aacaucaagg aagat                                                        15


<210> 10648
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10648
aacaucaagg aaga                                                         14


<210> 10649
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10649
aacaucaagg aag                                                          13


<210> 10650
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10650
acaucaagga agauggcauu ucuag                                             25


<210> 10651
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10651
acaucaagga agauggcauu ucta                                              24


<210> 10652
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10652
acaucaagga agauggcauu uct                                               23


<210> 10653
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10653
acaucaagga agauggcauu tc                                                22


<210> 10654
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10654
acaucaagga agauggcaut t                                                 21


<210> 10655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10655
acaucaagga agauggcatt                                                   20


<210> 10656
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10656
acaucaagga agauggcat                                                    19


<210> 10657
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10657
acaucaagga agauggca                                                     18


<210> 10658
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10658
acaucaagga agauggc                                                      17


<210> 10659
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10659
acaucaagga agaugg                                                       16


<210> 10660
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10660
acaucaagga agatg                                                        15


<210> 10661
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10661
acaucaagga agat                                                         14


<210> 10662
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10662
acaucaagga aga                                                          13


<210> 10663
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10663
acaucaagga ag                                                           12


<210> 10664
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10664
caucaaggaa gauggcauuu cuag                                              24


<210> 10665
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10665
caucaaggaa gauggcauuu cta                                               23


<210> 10666
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10666
caucaaggaa gauggcauuu ct                                                22


<210> 10667
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10667
caucaaggaa gauggcauut c                                                 21


<210> 10668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10668
caucaaggaa gauggcautt                                                   20


<210> 10669
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10669
caucaaggaa gauggcatt                                                    19


<210> 10670
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10670
caucaaggaa gauggcat                                                     18


<210> 10671
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10671
caucaaggaa gauggca                                                      17


<210> 10672
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10672
caucaaggaa gauggc                                                       16


<210> 10673
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10673
caucaaggaa gaugg                                                        15


<210> 10674
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10674
caucaaggaa gatg                                                         14


<210> 10675
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10675
caucaaggaa gat                                                          13


<210> 10676
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10676
caucaaggaa ga                                                           12


<210> 10677
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10677
caucaaggaa g                                                            11


<210> 10678
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10678
aucaaggaag auggcauuuc uag                                               23


<210> 10679
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10679
aucaaggaag auggcauuuc ta                                                22


<210> 10680
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10680
aucaaggaag auggcauuuc t                                                 21


<210> 10681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10681
aucaaggaag auggcauutc                                                   20


<210> 10682
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10682
aucaaggaag auggcautt                                                    19


<210> 10683
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10683
aucaaggaag auggcatt                                                     18


<210> 10684
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10684
aucaaggaag auggcat                                                      17


<210> 10685
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10685
aucaaggaag auggca                                                       16


<210> 10686
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10686
aucaaggaag auggc                                                        15


<210> 10687
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10687
aucaaggaag augg                                                         14


<210> 10688
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10688
aucaaggaag atg                                                          13


<210> 10689
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10689
aucaaggaag at                                                           12


<210> 10690
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10690
aucaaggaag a                                                            11


<210> 10691
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10691
aucaaggaag                                                              10


<210> 10692
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10692
ccagagcagg uaccuccaac atc                                               23


<210> 10693
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10693
ccagagcagg uaccucca                                                     18


<210> 10694
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10694
ccucugugau uuuauaacuu gat                                               23


<210> 10695
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10695
ucacccacca ucaccct                                                      17


<210> 10696
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10696
ugauauccuc aaggucaccc                                                   20


<210> 10697
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10697
cugcuugaug aucaucucgu tg                                                22


<210> 10698
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10698
cugcuugaug aucauctc                                                     18


<210> 10699
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10699
guuuccuuag uaaccacag                                                    19


<210> 10700
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10700
guuuccuuag uaaccac                                                      17


<210> 10701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10701
ucaaggaaga uggcauuuct                                                   20


<210> 10702
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10702
ucaaggaaga uggcauuucu ag                                                22


<210> 10703
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10703
gguaaguucu guccaagc                                                     18


<210> 10704
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10704
guaaguucug uccaagcc                                                     18


<210> 10705
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10705
agucgguaag uucugucc                                                     18


<210> 10706
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10706
cuguccaagc ccgguuga                                                     18


<210> 10707
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10707
uaaguucugu ccaag                                                        15


<210> 10708
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10708
uucuguccaa gcccgguuga                                                   20


<210> 10709
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10709
uucuguccaa gcccggutg                                                    19


<210> 10710
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10710
uucuguccaa gcccggtt                                                     18


<210> 10711
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10711
uucuguccaa gcccggt                                                      17


<210> 10712
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10712
uucuguccaa gcccgg                                                       16


<210> 10713
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10713
uucuguccaa gcccg                                                        15


<210> 10714
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10714
uucuguccaa gccc                                                         14


<210> 10715
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10715
uucuguccaa gcc                                                          13


<210> 10716
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10716
uucuguccaa gc                                                           12


<210> 10717
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10717
uucuguccaa g                                                            11


<210> 10718
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10718
uucuguccaa                                                              10


<210> 10719
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10719
uucugucca                                                                9


<210> 10720
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10720
uucugucc                                                                 8


<210> 10721
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10721
ucuguccaag cccgguuga                                                    19


<210> 10722
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10722
ucuguccaag cccggutg                                                     18


<210> 10723
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10723
ucuguccaag cccggtt                                                      17


<210> 10724
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10724
ucuguccaag cccggt                                                       16


<210> 10725
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10725
ucuguccaag cccgg                                                        15


<210> 10726
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10726
ucuguccaag cccg                                                         14


<210> 10727
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10727
ucuguccaag ccc                                                          13


<210> 10728
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10728
ucuguccaag cc                                                           12


<210> 10729
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10729
ucuguccaag c                                                            11


<210> 10730
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10730
ucuguccaag                                                              10


<210> 10731
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10731
ucuguccaa                                                                9


<210> 10732
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10732
ucugucca                                                                 8


<210> 10733
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10733
cuguccaagc ccggutg                                                      17


<210> 10734
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10734
cuguccaagc ccggtt                                                       16


<210> 10735
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10735
cuguccaagc ccggt                                                        15


<210> 10736
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10736
cuguccaagc ccgg                                                         14


<210> 10737
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10737
cuguccaagc ccg                                                          13


<210> 10738
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10738
cuguccaagc cc                                                           12


<210> 10739
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10739
cuguccaagc c                                                            11


<210> 10740
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10740
cuguccaagc                                                              10


<210> 10741
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10741
cuguccaag                                                                9


<210> 10742
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10742
cuguccaa                                                                 8


<210> 10743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10743
guucugucca agcccggutg                                                   20


<210> 10744
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10744
guucugucca agcccggtt                                                    19


<210> 10745
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10745
guucugucca agcccggt                                                     18


<210> 10746
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10746
guucugucca agcccgg                                                      17


<210> 10747
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10747
guucugucca agcccg                                                       16


<210> 10748
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10748
guucugucca agccc                                                        15


<210> 10749
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10749
guucugucca agcc                                                         14


<210> 10750
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10750
guucugucca agc                                                          13


<210> 10751
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10751
guucugucca ag                                                           12


<210> 10752
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10752
guucugucca a                                                            11


<210> 10753
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10753
guucugucca                                                              10


<210> 10754
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10754
guucugucc                                                                9


<210> 10755
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10755
guucugtc                                                                 8


<210> 10756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10756
aguucugucc aagcccggtt                                                   20


<210> 10757
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10757
aguucugucc aagcccggt                                                    19


<210> 10758
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10758
aguucugucc aagcccgg                                                     18


<210> 10759
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10759
aguucugucc aagcccg                                                      17


<210> 10760
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10760
aguucugucc aagccc                                                       16


<210> 10761
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10761
aguucugucc aagcc                                                        15


<210> 10762
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10762
aguucugucc aagc                                                         14


<210> 10763
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10763
aguucugucc aag                                                          13


<210> 10764
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10764
aguucugucc aa                                                           12


<210> 10765
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10765
aguucugucc a                                                            11


<210> 10766
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10766
aguucugucc                                                              10


<210> 10767
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10767
aguucugtc                                                                9


<210> 10768
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10768
aguucugt                                                                 8


<210> 10769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10769
aaguucuguc caagcccggt                                                   20


<210> 10770
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10770
aaguucuguc caagcccgg                                                    19


<210> 10771
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10771
aaguucuguc caagcccg                                                     18


<210> 10772
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10772
aaguucuguc caagccc                                                      17


<210> 10773
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10773
aaguucuguc caagcc                                                       16


<210> 10774
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10774
aaguucuguc caagc                                                        15


<210> 10775
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10775
aaguucuguc caag                                                         14


<210> 10776
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10776
aaguucuguc caa                                                          13


<210> 10777
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10777
aaguucuguc ca                                                           12


<210> 10778
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10778
aaguucuguc c                                                            11


<210> 10779
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10779
aaguucugtc                                                              10


<210> 10780
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10780
aaguucugt                                                                9


<210> 10781
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10781
aaguuctg                                                                 8


<210> 10782
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10782
uaaguucugu ccaagcccgg                                                   20


<210> 10783
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10783
uaaguucugu ccaagcccg                                                    19


<210> 10784
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10784
uaaguucugu ccaagccc                                                     18


<210> 10785
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10785
uaaguucugu ccaagcc                                                      17


<210> 10786
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10786
uaaguucugu ccaagc                                                       16


<210> 10787
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10787
uaaguucugu ccaa                                                         14


<210> 10788
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10788
uaaguucugu cca                                                          13


<210> 10789
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10789
uaaguucugu cc                                                           12


<210> 10790
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10790
uaaguucugt c                                                            11


<210> 10791
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10791
uaaguucugt                                                              10


<210> 10792
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10792
uaaguuctg                                                                9


<210> 10793
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10793
uaaguuct                                                                 8


<210> 10794
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10794
guaaguucug uccaagcccg                                                   20


<210> 10795
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10795
guaaguucug uccaagccc                                                    19


<210> 10796
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10796
guaaguucug uccaagc                                                      17


<210> 10797
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10797
guaaguucug uccaag                                                       16


<210> 10798
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10798
guaaguucug uccaa                                                        15


<210> 10799
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10799
guaaguucug ucca                                                         14


<210> 10800
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10800
guaaguucug ucc                                                          13


<210> 10801
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10801
guaaguucug tc                                                           12


<210> 10802
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10802
guaaguucug t                                                            11


<210> 10803
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10803
guaaguuctg                                                              10


<210> 10804
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10804
guaaguuct                                                                9


<210> 10805
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10805
guaagutc                                                                 8


<210> 10806
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10806
gguaaguucu guccaagccc                                                   20


<210> 10807
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10807
gguaaguucu guccaagcc                                                    19


<210> 10808
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10808
gguaaguucu guccaag                                                      17


<210> 10809
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10809
gguaaguucu guccaa                                                       16


<210> 10810
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10810
gguaaguucu gucca                                                        15


<210> 10811
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10811
gguaaguucu gucc                                                         14


<210> 10812
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10812
gguaaguucu gtc                                                          13


<210> 10813
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10813
gguaaguucu gt                                                           12


<210> 10814
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10814
gguaaguuct g                                                            11


<210> 10815
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10815
gguaaguuct                                                              10


<210> 10816
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10816
gguaagutc                                                                9


<210> 10817
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10817
gguaagtt                                                                 8


<210> 10818
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10818
cgguaaguuc uguccaagcc                                                   20


<210> 10819
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10819
cgguaaguuc uguccaagc                                                    19


<210> 10820
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10820
cgguaaguuc uguccaag                                                     18


<210> 10821
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10821
cgguaaguuc uguccaa                                                      17


<210> 10822
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10822
cgguaaguuc ugucca                                                       16


<210> 10823
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10823
cgguaaguuc ugucc                                                        15


<210> 10824
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10824
cgguaaguuc ugtc                                                         14


<210> 10825
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10825
cgguaaguuc ugt                                                          13


<210> 10826
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10826
cgguaaguuc tg                                                           12


<210> 10827
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10827
cgguaaguuc t                                                            11


<210> 10828
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10828
cgguaagutc                                                              10


<210> 10829
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10829
cgguaagtt                                                                9


<210> 10830
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10830
cgguaagt                                                                 8


<210> 10831
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10831
ucgguaaguu cuguccaagc                                                   20


<210> 10832
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10832
ucgguaaguu cuguccaag                                                    19


<210> 10833
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10833
ucgguaaguu cuguccaa                                                     18


<210> 10834
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10834
ucgguaaguu cugucca                                                      17


<210> 10835
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10835
ucgguaaguu cugucc                                                       16


<210> 10836
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10836
ucgguaaguu cugtc                                                        15


<210> 10837
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10837
ucgguaaguu cugt                                                         14


<210> 10838
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10838
ucgguaaguu ctg                                                          13


<210> 10839
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10839
ucgguaaguu ct                                                           12


<210> 10840
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10840
ucgguaagut c                                                            11


<210> 10841
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10841
ucgguaagtt                                                              10


<210> 10842
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10842
ucgguaagt                                                                9


<210> 10843
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10843
gucgguaagu ucuguccaag                                                   20


<210> 10844
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10844
gucgguaagu ucuguccaa                                                    19


<210> 10845
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10845
gucgguaagu ucugucca                                                     18


<210> 10846
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10846
gucgguaagu ucugucc                                                      17


<210> 10847
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10847
gucgguaagu ucugtc                                                       16


<210> 10848
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10848
gucgguaagu ucugt                                                        15


<210> 10849
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10849
gucgguaagu uctg                                                         14


<210> 10850
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10850
gucgguaagu uct                                                          13


<210> 10851
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10851
gucgguaagu tc                                                           12


<210> 10852
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10852
gucgguaagt t                                                            11


<210> 10853
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10853
gucgguaagt                                                              10


<210> 10854
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10854
agucgguaag uucuguccaa                                                   20


<210> 10855
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10855
agucgguaag uucugucca                                                    19


<210> 10856
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10856
agucgguaag uucugtc                                                      17


<210> 10857
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10857
agucgguaag uucugt                                                       16


<210> 10858
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10858
agucgguaag uuctg                                                        15


<210> 10859
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10859
agucgguaag uuct                                                         14


<210> 10860
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10860
agucgguaag utc                                                          13


<210> 10861
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10861
agucgguaag tt                                                           12


<210> 10862
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10862
agucgguaag t                                                            11


<210> 10863
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10863
cagucgguaa guucugucca                                                   20


<210> 10864
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10864
cagucgguaa guucugucc                                                    19


<210> 10865
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10865
cagucgguaa guucugtc                                                     18


<210> 10866
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10866
cagucgguaa guucugt                                                      17


<210> 10867
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10867
cagucgguaa guuctg                                                       16


<210> 10868
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10868
cagucgguaa guuct                                                        15


<210> 10869
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10869
cagucgguaa gutc                                                         14


<210> 10870
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10870
cagucgguaa gtt                                                          13


<210> 10871
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10871
cagucgguaa gt                                                           12


<210> 10872
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10872
ccagucggua aguucugucc                                                   20


<210> 10873
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10873
ccagucggua aguucugtc                                                    19


<210> 10874
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10874
ccagucggua aguucugt                                                     18


<210> 10875
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10875
ccagucggua aguuctg                                                      17


<210> 10876
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10876
ccagucggua aguuct                                                       16


<210> 10877
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10877
ccagucggua agutc                                                        15


<210> 10878
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10878
ccagucggua agtt                                                         14


<210> 10879
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10879
ccagucggua agt                                                          13


<210> 10880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10880
gccagucggu aaguucugtc                                                   20


<210> 10881
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10881
gccagucggu aaguucugt                                                    19


<210> 10882
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10882
gccagucggu aaguuctg                                                     18


<210> 10883
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10883
gccagucggu aaguuct                                                      17


<210> 10884
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10884
gccagucggu aagutc                                                       16


<210> 10885
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10885
gccagucggu aagtt                                                        15


<210> 10886
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10886
gccagucggu aagt                                                         14


<210> 10887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10887
ucaaggaaga uggcauuuct                                                   20


<210> 10888
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10888
ucaaggaaga uggcauuucu ag                                                22


<210> 10889
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10889
ucaaggaaga uggcat                                                       16


<210> 10890
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10890
gaagauggca uuuct                                                        15


<210> 10891
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10891
ucaaggaaga uggcauuuct a                                                 21


<210> 10892
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10892
ucaaggaaga uggcauutc                                                    19


<210> 10893
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10893
ucaaggaaga uggcautt                                                     18


<210> 10894
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10894
ucaaggaaga uggcatt                                                      17


<210> 10895
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10895
ucaaggaaga uggca                                                        15


<210> 10896
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10896
ucaaggaaga uggc                                                         14


<210> 10897
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10897
ucaaggaaga ugg                                                          13


<210> 10898
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10898
ucaaggaaga tg                                                           12


<210> 10899
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10899
ucaaggaaga t                                                            11


<210> 10900
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10900
ucaaggaaga                                                              10


<210> 10901
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10901
ucaaggaag                                                                9


<210> 10902
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10902
caaggaagau ggcauuucua g                                                 21


<210> 10903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10903
caaggaagau ggcauuucta                                                   20


<210> 10904
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10904
caaggaagau ggcauuuct                                                    19


<210> 10905
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10905
caaggaagau ggcauutc                                                     18


<210> 10906
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10906
caaggaagau ggcautt                                                      17


<210> 10907
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10907
caaggaagau ggcatt                                                       16


<210> 10908
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10908
caaggaagau ggcat                                                        15


<210> 10909
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10909
caaggaagau ggca                                                         14


<210> 10910
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10910
caaggaagau ggc                                                          13


<210> 10911
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10911
caaggaagau gg                                                           12


<210> 10912
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10912
caaggaagat g                                                            11


<210> 10913
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10913
caaggaagat                                                              10


<210> 10914
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10914
caaggaaga                                                                9


<210> 10915
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10915
caaggaag                                                                 8


<210> 10916
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10916
aaggaagaug gcauuucuag                                                   20


<210> 10917
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10917
aaggaagaug gcauuucta                                                    19


<210> 10918
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10918
aaggaagaug gcauuuct                                                     18


<210> 10919
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10919
aaggaagaug gcauutc                                                      17


<210> 10920
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10920
aaggaagaug gcautt                                                       16


<210> 10921
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10921
aaggaagaug gcatt                                                        15


<210> 10922
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10922
aaggaagaug gcat                                                         14


<210> 10923
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10923
aaggaagaug gca                                                          13


<210> 10924
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10924
aaggaagaug gc                                                           12


<210> 10925
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10925
aaggaagaug g                                                            11


<210> 10926
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10926
aaggaagatg                                                              10


<210> 10927
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10927
aaggaagat                                                                9


<210> 10928
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10928
aaggaaga                                                                 8


<210> 10929
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10929
aggaagaugg cauuucuag                                                    19


<210> 10930
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10930
aggaagaugg cauuucta                                                     18


<210> 10931
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10931
aggaagaugg cauuuct                                                      17


<210> 10932
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10932
aggaagaugg cauutc                                                       16


<210> 10933
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10933
aggaagaugg cautt                                                        15


<210> 10934
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10934
aggaagaugg catt                                                         14


<210> 10935
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10935
aggaagaugg cat                                                          13


<210> 10936
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10936
aggaagaugg ca                                                           12


<210> 10937
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10937
aggaagaugg                                                              10


<210> 10938
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10938
aggaagatg                                                                9


<210> 10939
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10939
aggaagat                                                                 8


<210> 10940
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10940
ggaagauggc auuucuag                                                     18


<210> 10941
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10941
ggaagauggc auuucta                                                      17


<210> 10942
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10942
ggaagauggc auuuct                                                       16


<210> 10943
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10943
ggaagauggc auutc                                                        15


<210> 10944
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10944
ggaagauggc autt                                                         14


<210> 10945
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10945
ggaagauggc att                                                          13


<210> 10946
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10946
ggaagauggc at                                                           12


<210> 10947
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10947
ggaagauggc a                                                            11


<210> 10948
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10948
ggaagauggc                                                              10


<210> 10949
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10949
ggaagatg                                                                 8


<210> 10950
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10950
gaagauggca uuucuag                                                      17


<210> 10951
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10951
gaagauggca uuucta                                                       16


<210> 10952
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10952
gaagauggca uutc                                                         14


<210> 10953
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10953
gaagauggca utt                                                          13


<210> 10954
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10954
gaagauggca tt                                                           12


<210> 10955
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10955
gaagauggca t                                                            11


<210> 10956
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10956
gaagauggca                                                              10


<210> 10957
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10957
gaagauggc                                                                9


<210> 10958
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10958
gaagaugg                                                                 8


<210> 10959
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10959
aagauggcau uucuag                                                       16


<210> 10960
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10960
aagauggcau uucta                                                        15


<210> 10961
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10961
aagauggcau uuct                                                         14


<210> 10962
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10962
aagauggcau utc                                                          13


<210> 10963
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10963
aagauggcau tt                                                           12


<210> 10964
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10964
aagauggcat t                                                            11


<210> 10965
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10965
aagauggcat                                                              10


<210> 10966
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10966
aagauggca                                                                9


<210> 10967
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10967
aagauggc                                                                 8


<210> 10968
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10968
agauggcauu ucuag                                                        15


<210> 10969
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10969
agauggcauu ucta                                                         14


<210> 10970
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10970
agauggcauu uct                                                          13


<210> 10971
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10971
agauggcauu tc                                                           12


<210> 10972
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10972
agauggcaut t                                                            11


<210> 10973
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10973
agauggcatt                                                              10


<210> 10974
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10974
agauggcat                                                                9


<210> 10975
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10975
agauggca                                                                 8


<210> 10976
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10976
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 10977
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10977
cuccaacauc aaggaagaug gcauuucta                                         29


<210> 10978
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10978
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 10979
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10979
cuccaacauc aaggaagaug gcauutc                                           27


<210> 10980
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10980
cuccaacauc aaggaagaug gcautt                                            26


<210> 10981
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10981
cuccaacauc aaggaagaug gcatt                                             25


<210> 10982
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10982
cuccaacauc aaggaagaug gcat                                              24


<210> 10983
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10983
cuccaacauc aaggaagaug gca                                               23


<210> 10984
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10984
cuccaacauc aaggaagaug gc                                                22


<210> 10985
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10985
cuccaacauc aaggaagaug g                                                 21


<210> 10986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10986
cuccaacauc aaggaagatg                                                   20


<210> 10987
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10987
cuccaacauc aaggaagat                                                    19


<210> 10988
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10988
cuccaacauc aaggaaga                                                     18


<210> 10989
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10989
cuccaacauc aaggaag                                                      17


<210> 10990
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10990
uccaacauca aggaagaugg cauuucuag                                         29


<210> 10991
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10991
uccaacauca aggaagaugg cauuucta                                          28


<210> 10992
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10992
uccaacauca aggaagaugg cauuuct                                           27


<210> 10993
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10993
uccaacauca aggaagaugg cauutc                                            26


<210> 10994
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10994
uccaacauca aggaagaugg cautt                                             25


<210> 10995
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10995
uccaacauca aggaagaugg catt                                              24


<210> 10996
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10996
uccaacauca aggaagaugg cat                                               23


<210> 10997
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10997
uccaacauca aggaagaugg ca                                                22


<210> 10998
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10998
uccaacauca aggaagaugg c                                                 21


<210> 10999
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 10999
uccaacauca aggaagaugg                                                   20


<210> 11000
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11000
uccaacauca aggaagatg                                                    19


<210> 11001
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11001
uccaacauca aggaagat                                                     18


<210> 11002
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11002
uccaacauca aggaaga                                                      17


<210> 11003
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11003
uccaacauca aggaag                                                       16


<210> 11004
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11004
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 11005
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11005
ccaacaucaa ggaagauggc auuucta                                           27


<210> 11006
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11006
ccaacaucaa ggaagauggc auuuct                                            26


<210> 11007
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11007
ccaacaucaa ggaagauggc auutc                                             25


<210> 11008
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11008
ccaacaucaa ggaagauggc autt                                              24


<210> 11009
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11009
ccaacaucaa ggaagauggc att                                               23


<210> 11010
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11010
ccaacaucaa ggaagauggc at                                                22


<210> 11011
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11011
ccaacaucaa ggaagauggc a                                                 21


<210> 11012
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11012
ccaacaucaa ggaagauggc                                                   20


<210> 11013
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11013
ccaacaucaa ggaagaugg                                                    19


<210> 11014
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11014
ccaacaucaa ggaagatg                                                     18


<210> 11015
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11015
ccaacaucaa ggaagat                                                      17


<210> 11016
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11016
ccaacaucaa ggaaga                                                       16


<210> 11017
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11017
ccaacaucaa ggaag                                                        15


<210> 11018
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11018
caacaucaag gaagauggca uuucuag                                           27


<210> 11019
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11019
caacaucaag gaagauggca uuucta                                            26


<210> 11020
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11020
caacaucaag gaagauggca uuuct                                             25


<210> 11021
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11021
caacaucaag gaagauggca uutc                                              24


<210> 11022
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11022
caacaucaag gaagauggca utt                                               23


<210> 11023
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11023
caacaucaag gaagauggca tt                                                22


<210> 11024
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11024
caacaucaag gaagauggca t                                                 21


<210> 11025
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11025
caacaucaag gaagauggca                                                   20


<210> 11026
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11026
caacaucaag gaagauggc                                                    19


<210> 11027
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11027
caacaucaag gaagaugg                                                     18


<210> 11028
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11028
caacaucaag gaagatg                                                      17


<210> 11029
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11029
caacaucaag gaagat                                                       16


<210> 11030
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11030
caacaucaag gaaga                                                        15


<210> 11031
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11031
caacaucaag gaag                                                         14


<210> 11032
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11032
aacaucaagg aagauggcau uucuag                                            26


<210> 11033
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11033
aacaucaagg aagauggcau uucta                                             25


<210> 11034
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11034
aacaucaagg aagauggcau uuct                                              24


<210> 11035
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11035
aacaucaagg aagauggcau utc                                               23


<210> 11036
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11036
aacaucaagg aagauggcau tt                                                22


<210> 11037
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11037
aacaucaagg aagauggcat t                                                 21


<210> 11038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11038
aacaucaagg aagauggcat                                                   20


<210> 11039
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11039
aacaucaagg aagauggca                                                    19


<210> 11040
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11040
aacaucaagg aagauggc                                                     18


<210> 11041
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11041
aacaucaagg aagaugg                                                      17


<210> 11042
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11042
aacaucaagg aagatg                                                       16


<210> 11043
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11043
aacaucaagg aagat                                                        15


<210> 11044
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11044
aacaucaagg aaga                                                         14


<210> 11045
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11045
aacaucaagg aag                                                          13


<210> 11046
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11046
acaucaagga agauggcauu ucuag                                             25


<210> 11047
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11047
acaucaagga agauggcauu ucta                                              24


<210> 11048
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11048
acaucaagga agauggcauu uct                                               23


<210> 11049
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11049
acaucaagga agauggcauu tc                                                22


<210> 11050
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11050
acaucaagga agauggcaut t                                                 21


<210> 11051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11051
acaucaagga agauggcatt                                                   20


<210> 11052
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11052
acaucaagga agauggcat                                                    19


<210> 11053
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11053
acaucaagga agauggca                                                     18


<210> 11054
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11054
acaucaagga agauggc                                                      17


<210> 11055
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11055
acaucaagga agaugg                                                       16


<210> 11056
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11056
acaucaagga agatg                                                        15


<210> 11057
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11057
acaucaagga agat                                                         14


<210> 11058
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11058
acaucaagga aga                                                          13


<210> 11059
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11059
acaucaagga ag                                                           12


<210> 11060
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11060
caucaaggaa gauggcauuu cuag                                              24


<210> 11061
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11061
caucaaggaa gauggcauuu cta                                               23


<210> 11062
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11062
caucaaggaa gauggcauuu ct                                                22


<210> 11063
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11063
caucaaggaa gauggcauut c                                                 21


<210> 11064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11064
caucaaggaa gauggcautt                                                   20


<210> 11065
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11065
caucaaggaa gauggcatt                                                    19


<210> 11066
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11066
caucaaggaa gauggcat                                                     18


<210> 11067
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11067
caucaaggaa gauggca                                                      17


<210> 11068
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11068
caucaaggaa gauggc                                                       16


<210> 11069
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11069
caucaaggaa gaugg                                                        15


<210> 11070
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11070
caucaaggaa gatg                                                         14


<210> 11071
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11071
caucaaggaa gat                                                          13


<210> 11072
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11072
caucaaggaa ga                                                           12


<210> 11073
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11073
caucaaggaa g                                                            11


<210> 11074
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11074
aucaaggaag auggcauuuc uag                                               23


<210> 11075
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11075
aucaaggaag auggcauuuc ta                                                22


<210> 11076
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11076
aucaaggaag auggcauuuc t                                                 21


<210> 11077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11077
aucaaggaag auggcauutc                                                   20


<210> 11078
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11078
aucaaggaag auggcautt                                                    19


<210> 11079
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11079
aucaaggaag auggcatt                                                     18


<210> 11080
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11080
aucaaggaag auggcat                                                      17


<210> 11081
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11081
aucaaggaag auggca                                                       16


<210> 11082
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11082
aucaaggaag auggc                                                        15


<210> 11083
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11083
aucaaggaag augg                                                         14


<210> 11084
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11084
aucaaggaag atg                                                          13


<210> 11085
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11085
aucaaggaag at                                                           12


<210> 11086
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11086
aucaaggaag a                                                            11


<210> 11087
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11087
aucaaggaag                                                              10


<210> 11088
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11088
ccagagcagg uaccuccaac atc                                               23


<210> 11089
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11089
ccagagcagg uaccucca                                                     18


<210> 11090
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11090
ccucugugau uuuauaacuu gat                                               23


<210> 11091
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11091
ucacccacca ucaccct                                                      17


<210> 11092
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11092
ugauauccuc aaggucaccc                                                   20


<210> 11093
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11093
cugcuugaug aucaucucgu tg                                                22


<210> 11094
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11094
cugcuugaug aucauctc                                                     18


<210> 11095
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11095
guuuccuuag uaaccacag                                                    19


<210> 11096
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11096
guuuccuuag uaaccac                                                      17


<210> 11097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11097
tcaaggaaga uggcauuuct                                                   20


<210> 11098
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11098
tcaaggaaga uggcauuucu ag                                                22


<210> 11099
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11099
gguaaguucu guccaagc                                                     18


<210> 11100
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11100
gtaaguucug uccaagcc                                                     18


<210> 11101
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11101
agucgguaag uucugucc                                                     18


<210> 11102
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11102
ctguccaagc ccgguuga                                                     18


<210> 11103
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11103
taaguucugu ccaag                                                        15


<210> 11104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11104
ttcuguccaa gcccgguuga                                                   20


<210> 11105
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11105
ttcuguccaa gcccggutg                                                    19


<210> 11106
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11106
ttcuguccaa gcccggtt                                                     18


<210> 11107
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11107
ttcuguccaa gcccggt                                                      17


<210> 11108
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11108
ttcuguccaa gcccgg                                                       16


<210> 11109
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11109
ttcuguccaa gcccg                                                        15


<210> 11110
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11110
ttcuguccaa gccc                                                         14


<210> 11111
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11111
ttcuguccaa gcc                                                          13


<210> 11112
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11112
ttcuguccaa gc                                                           12


<210> 11113
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11113
ttcuguccaa g                                                            11


<210> 11114
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11114
ttcuguccaa                                                              10


<210> 11115
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11115
ttcugucca                                                                9


<210> 11116
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11116
ttcugucc                                                                 8


<210> 11117
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11117
tcuguccaag cccgguuga                                                    19


<210> 11118
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11118
tcuguccaag cccggutg                                                     18


<210> 11119
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11119
tcuguccaag cccggtt                                                      17


<210> 11120
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11120
tcuguccaag cccggt                                                       16


<210> 11121
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11121
tcuguccaag cccgg                                                        15


<210> 11122
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11122
tcuguccaag cccg                                                         14


<210> 11123
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11123
tcuguccaag ccc                                                          13


<210> 11124
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11124
tcuguccaag cc                                                           12


<210> 11125
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11125
tcuguccaag c                                                            11


<210> 11126
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11126
tcuguccaag                                                              10


<210> 11127
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11127
tcuguccaa                                                                9


<210> 11128
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11128
tcugucca                                                                 8


<210> 11129
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11129
ctguccaagc ccggutg                                                      17


<210> 11130
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11130
ctguccaagc ccggtt                                                       16


<210> 11131
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11131
ctguccaagc ccggt                                                        15


<210> 11132
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11132
ctguccaagc ccgg                                                         14


<210> 11133
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11133
ctguccaagc ccg                                                          13


<210> 11134
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11134
ctguccaagc cc                                                           12


<210> 11135
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11135
ctguccaagc c                                                            11


<210> 11136
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11136
ctguccaagc                                                              10


<210> 11137
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11137
ctguccaag                                                                9


<210> 11138
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11138
ctguccaa                                                                 8


<210> 11139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11139
gtucugucca agcccggutg                                                   20


<210> 11140
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11140
gtucugucca agcccggtt                                                    19


<210> 11141
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11141
gtucugucca agcccggt                                                     18


<210> 11142
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11142
gtucugucca agcccgg                                                      17


<210> 11143
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11143
gtucugucca agcccg                                                       16


<210> 11144
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11144
gtucugucca agccc                                                        15


<210> 11145
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11145
gtucugucca agcc                                                         14


<210> 11146
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11146
gtucugucca agc                                                          13


<210> 11147
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11147
gtucugucca ag                                                           12


<210> 11148
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11148
gtucugucca a                                                            11


<210> 11149
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11149
gtucugucca                                                              10


<210> 11150
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11150
gtucugucc                                                                9


<210> 11151
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11151
gtucugtc                                                                 8


<210> 11152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11152
aguucugucc aagcccggtt                                                   20


<210> 11153
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11153
aguucugucc aagcccggt                                                    19


<210> 11154
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11154
aguucugucc aagcccgg                                                     18


<210> 11155
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11155
aguucugucc aagcccg                                                      17


<210> 11156
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11156
aguucugucc aagccc                                                       16


<210> 11157
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11157
aguucugucc aagcc                                                        15


<210> 11158
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11158
aguucugucc aagc                                                         14


<210> 11159
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11159
aguucugucc aag                                                          13


<210> 11160
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11160
aguucugucc aa                                                           12


<210> 11161
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11161
aguucugucc a                                                            11


<210> 11162
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11162
aguucugucc                                                              10


<210> 11163
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11163
aguucugtc                                                                9


<210> 11164
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11164
aguucugt                                                                 8


<210> 11165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11165
aaguucuguc caagcccggt                                                   20


<210> 11166
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11166
aaguucuguc caagcccgg                                                    19


<210> 11167
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11167
aaguucuguc caagcccg                                                     18


<210> 11168
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11168
aaguucuguc caagccc                                                      17


<210> 11169
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11169
aaguucuguc caagcc                                                       16


<210> 11170
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11170
aaguucuguc caagc                                                        15


<210> 11171
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11171
aaguucuguc caag                                                         14


<210> 11172
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11172
aaguucuguc caa                                                          13


<210> 11173
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11173
aaguucuguc ca                                                           12


<210> 11174
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11174
aaguucuguc c                                                            11


<210> 11175
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11175
aaguucugtc                                                              10


<210> 11176
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11176
aaguucugt                                                                9


<210> 11177
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11177
aaguuctg                                                                 8


<210> 11178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11178
taaguucugu ccaagcccgg                                                   20


<210> 11179
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11179
taaguucugu ccaagcccg                                                    19


<210> 11180
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11180
taaguucugu ccaagccc                                                     18


<210> 11181
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11181
taaguucugu ccaagcc                                                      17


<210> 11182
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11182
taaguucugu ccaagc                                                       16


<210> 11183
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11183
taaguucugu ccaa                                                         14


<210> 11184
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11184
taaguucugu cca                                                          13


<210> 11185
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11185
taaguucugu cc                                                           12


<210> 11186
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11186
taaguucugt c                                                            11


<210> 11187
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11187
taaguucugt                                                              10


<210> 11188
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11188
taaguuctg                                                                9


<210> 11189
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11189
taaguuct                                                                 8


<210> 11190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11190
gtaaguucug uccaagcccg                                                   20


<210> 11191
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11191
gtaaguucug uccaagccc                                                    19


<210> 11192
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11192
gtaaguucug uccaagc                                                      17


<210> 11193
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11193
gtaaguucug uccaag                                                       16


<210> 11194
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11194
gtaaguucug uccaa                                                        15


<210> 11195
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11195
gtaaguucug ucca                                                         14


<210> 11196
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11196
gtaaguucug ucc                                                          13


<210> 11197
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11197
gtaaguucug tc                                                           12


<210> 11198
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11198
gtaaguucug t                                                            11


<210> 11199
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11199
gtaaguuctg                                                              10


<210> 11200
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11200
gtaaguuct                                                                9


<210> 11201
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11201
gtaagutc                                                                 8


<210> 11202
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11202
gguaaguucu guccaagccc                                                   20


<210> 11203
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11203
gguaaguucu guccaagcc                                                    19


<210> 11204
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11204
gguaaguucu guccaag                                                      17


<210> 11205
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11205
gguaaguucu guccaa                                                       16


<210> 11206
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11206
gguaaguucu gucca                                                        15


<210> 11207
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11207
gguaaguucu gucc                                                         14


<210> 11208
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11208
gguaaguucu gtc                                                          13


<210> 11209
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11209
gguaaguucu gt                                                           12


<210> 11210
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11210
gguaaguuct g                                                            11


<210> 11211
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11211
gguaaguuct                                                              10


<210> 11212
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11212
gguaagutc                                                                9


<210> 11213
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11213
gguaagtt                                                                 8


<210> 11214
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11214
cgguaaguuc uguccaagcc                                                   20


<210> 11215
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11215
cgguaaguuc uguccaagc                                                    19


<210> 11216
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11216
cgguaaguuc uguccaag                                                     18


<210> 11217
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11217
cgguaaguuc uguccaa                                                      17


<210> 11218
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11218
cgguaaguuc ugucca                                                       16


<210> 11219
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11219
cgguaaguuc ugucc                                                        15


<210> 11220
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11220
cgguaaguuc ugtc                                                         14


<210> 11221
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11221
cgguaaguuc ugt                                                          13


<210> 11222
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11222
cgguaaguuc tg                                                           12


<210> 11223
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11223
cgguaaguuc t                                                            11


<210> 11224
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11224
cgguaagutc                                                              10


<210> 11225
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11225
cgguaagtt                                                                9


<210> 11226
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11226
cgguaagt                                                                 8


<210> 11227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11227
tcgguaaguu cuguccaagc                                                   20


<210> 11228
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11228
tcgguaaguu cuguccaag                                                    19


<210> 11229
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11229
tcgguaaguu cuguccaa                                                     18


<210> 11230
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11230
tcgguaaguu cugucca                                                      17


<210> 11231
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11231
tcgguaaguu cugucc                                                       16


<210> 11232
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11232
tcgguaaguu cugtc                                                        15


<210> 11233
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11233
tcgguaaguu cugt                                                         14


<210> 11234
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11234
tcgguaaguu ctg                                                          13


<210> 11235
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11235
tcgguaaguu ct                                                           12


<210> 11236
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11236
tcgguaagut c                                                            11


<210> 11237
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11237
tcgguaagtt                                                              10


<210> 11238
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11238
tcgguaagt                                                                9


<210> 11239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11239
gtcgguaagu ucuguccaag                                                   20


<210> 11240
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11240
gtcgguaagu ucuguccaa                                                    19


<210> 11241
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11241
gtcgguaagu ucugucca                                                     18


<210> 11242
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11242
gtcgguaagu ucugucc                                                      17


<210> 11243
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11243
gtcgguaagu ucugtc                                                       16


<210> 11244
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11244
gtcgguaagu ucugt                                                        15


<210> 11245
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11245
gtcgguaagu uctg                                                         14


<210> 11246
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11246
gtcgguaagu uct                                                          13


<210> 11247
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11247
gtcgguaagu tc                                                           12


<210> 11248
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11248
gtcgguaagt t                                                            11


<210> 11249
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11249
gtcgguaagt                                                              10


<210> 11250
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11250
agucgguaag uucuguccaa                                                   20


<210> 11251
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11251
agucgguaag uucugucca                                                    19


<210> 11252
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11252
agucgguaag uucugtc                                                      17


<210> 11253
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11253
agucgguaag uucugt                                                       16


<210> 11254
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11254
agucgguaag uuctg                                                        15


<210> 11255
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11255
agucgguaag uuct                                                         14


<210> 11256
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11256
agucgguaag utc                                                          13


<210> 11257
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11257
agucgguaag tt                                                           12


<210> 11258
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11258
agucgguaag t                                                            11


<210> 11259
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11259
cagucgguaa guucugucca                                                   20


<210> 11260
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11260
cagucgguaa guucugucc                                                    19


<210> 11261
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11261
cagucgguaa guucugtc                                                     18


<210> 11262
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11262
cagucgguaa guucugt                                                      17


<210> 11263
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11263
cagucgguaa guuctg                                                       16


<210> 11264
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11264
cagucgguaa guuct                                                        15


<210> 11265
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11265
cagucgguaa gutc                                                         14


<210> 11266
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11266
cagucgguaa gtt                                                          13


<210> 11267
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11267
cagucgguaa gt                                                           12


<210> 11268
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11268
ccagucggua aguucugucc                                                   20


<210> 11269
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11269
ccagucggua aguucugtc                                                    19


<210> 11270
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11270
ccagucggua aguucugt                                                     18


<210> 11271
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11271
ccagucggua aguuctg                                                      17


<210> 11272
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11272
ccagucggua aguuct                                                       16


<210> 11273
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11273
ccagucggua agutc                                                        15


<210> 11274
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11274
ccagucggua agtt                                                         14


<210> 11275
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11275
ccagucggua agt                                                          13


<210> 11276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11276
gccagucggu aaguucugtc                                                   20


<210> 11277
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11277
gccagucggu aaguucugt                                                    19


<210> 11278
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11278
gccagucggu aaguuctg                                                     18


<210> 11279
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11279
gccagucggu aaguuct                                                      17


<210> 11280
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11280
gccagucggu aagutc                                                       16


<210> 11281
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11281
gccagucggu aagtt                                                        15


<210> 11282
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11282
gccagucggu aagt                                                         14


<210> 11283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11283
tcaaggaaga uggcauuuct                                                   20


<210> 11284
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11284
tcaaggaaga uggcauuucu ag                                                22


<210> 11285
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11285
tcaaggaaga uggcat                                                       16


<210> 11286
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11286
gaagauggca uuuct                                                        15


<210> 11287
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11287
tcaaggaaga uggcauuuct a                                                 21


<210> 11288
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11288
tcaaggaaga uggcauutc                                                    19


<210> 11289
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11289
tcaaggaaga uggcautt                                                     18


<210> 11290
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11290
tcaaggaaga uggcatt                                                      17


<210> 11291
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11291
tcaaggaaga uggca                                                        15


<210> 11292
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11292
tcaaggaaga uggc                                                         14


<210> 11293
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11293
tcaaggaaga ugg                                                          13


<210> 11294
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11294
tcaaggaaga tg                                                           12


<210> 11295
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11295
tcaaggaaga t                                                            11


<210> 11296
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11296
tcaaggaaga                                                              10


<210> 11297
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11297
tcaaggaag                                                                9


<210> 11298
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11298
caaggaagau ggcauuucua g                                                 21


<210> 11299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11299
caaggaagau ggcauuucta                                                   20


<210> 11300
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11300
caaggaagau ggcauuuct                                                    19


<210> 11301
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11301
caaggaagau ggcauutc                                                     18


<210> 11302
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11302
caaggaagau ggcautt                                                      17


<210> 11303
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11303
caaggaagau ggcatt                                                       16


<210> 11304
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11304
caaggaagau ggcat                                                        15


<210> 11305
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11305
caaggaagau ggca                                                         14


<210> 11306
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11306
caaggaagau ggc                                                          13


<210> 11307
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11307
caaggaagau gg                                                           12


<210> 11308
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11308
caaggaagat g                                                            11


<210> 11309
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11309
caaggaagat                                                              10


<210> 11310
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11310
caaggaaga                                                                9


<210> 11311
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11311
caaggaag                                                                 8


<210> 11312
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11312
aaggaagaug gcauuucuag                                                   20


<210> 11313
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11313
aaggaagaug gcauuucta                                                    19


<210> 11314
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11314
aaggaagaug gcauuuct                                                     18


<210> 11315
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11315
aaggaagaug gcauutc                                                      17


<210> 11316
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11316
aaggaagaug gcautt                                                       16


<210> 11317
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11317
aaggaagaug gcatt                                                        15


<210> 11318
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11318
aaggaagaug gcat                                                         14


<210> 11319
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11319
aaggaagaug gca                                                          13


<210> 11320
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11320
aaggaagaug gc                                                           12


<210> 11321
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11321
aaggaagaug g                                                            11


<210> 11322
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11322
aaggaagatg                                                              10


<210> 11323
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11323
aaggaagat                                                                9


<210> 11324
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11324
aaggaaga                                                                 8


<210> 11325
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11325
aggaagaugg cauuucuag                                                    19


<210> 11326
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11326
aggaagaugg cauuucta                                                     18


<210> 11327
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11327
aggaagaugg cauuuct                                                      17


<210> 11328
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11328
aggaagaugg cauutc                                                       16


<210> 11329
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11329
aggaagaugg cautt                                                        15


<210> 11330
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11330
aggaagaugg catt                                                         14


<210> 11331
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11331
aggaagaugg cat                                                          13


<210> 11332
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11332
aggaagaugg ca                                                           12


<210> 11333
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11333
aggaagaugg                                                              10


<210> 11334
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11334
aggaagatg                                                                9


<210> 11335
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11335
aggaagat                                                                 8


<210> 11336
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11336
ggaagauggc auuucuag                                                     18


<210> 11337
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11337
ggaagauggc auuucta                                                      17


<210> 11338
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11338
ggaagauggc auuuct                                                       16


<210> 11339
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11339
ggaagauggc auutc                                                        15


<210> 11340
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11340
ggaagauggc autt                                                         14


<210> 11341
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11341
ggaagauggc att                                                          13


<210> 11342
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11342
ggaagauggc at                                                           12


<210> 11343
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11343
ggaagauggc a                                                            11


<210> 11344
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11344
ggaagauggc                                                              10


<210> 11345
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11345
ggaagatg                                                                 8


<210> 11346
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11346
gaagauggca uuucuag                                                      17


<210> 11347
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11347
gaagauggca uuucta                                                       16


<210> 11348
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11348
gaagauggca uutc                                                         14


<210> 11349
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11349
gaagauggca utt                                                          13


<210> 11350
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11350
gaagauggca tt                                                           12


<210> 11351
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11351
gaagauggca t                                                            11


<210> 11352
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11352
gaagauggca                                                              10


<210> 11353
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11353
gaagauggc                                                                9


<210> 11354
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11354
gaagaugg                                                                 8


<210> 11355
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11355
aagauggcau uucuag                                                       16


<210> 11356
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11356
aagauggcau uucta                                                        15


<210> 11357
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11357
aagauggcau uuct                                                         14


<210> 11358
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11358
aagauggcau utc                                                          13


<210> 11359
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11359
aagauggcau tt                                                           12


<210> 11360
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11360
aagauggcat t                                                            11


<210> 11361
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11361
aagauggcat                                                              10


<210> 11362
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11362
aagauggca                                                                9


<210> 11363
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11363
aagauggc                                                                 8


<210> 11364
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11364
agauggcauu ucuag                                                        15


<210> 11365
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11365
agauggcauu ucta                                                         14


<210> 11366
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11366
agauggcauu uct                                                          13


<210> 11367
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11367
agauggcauu tc                                                           12


<210> 11368
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11368
agauggcaut t                                                            11


<210> 11369
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11369
agauggcatt                                                              10


<210> 11370
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11370
agauggcat                                                                9


<210> 11371
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11371
agauggca                                                                 8


<210> 11372
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 11372
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 11373
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 11373
ctccaacauc aaggaagaug gcauuucta                                         29


<210> 11374
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 11374
ctccaacauc aaggaagaug gcauuuct                                          28


<210> 11375
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 11375
ctccaacauc aaggaagaug gcauutc                                           27


<210> 11376
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 11376
ctccaacauc aaggaagaug gcautt                                            26


<210> 11377
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11377
ctccaacauc aaggaagaug gcatt                                             25


<210> 11378
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11378
ctccaacauc aaggaagaug gcat                                              24


<210> 11379
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11379
ctccaacauc aaggaagaug gca                                               23


<210> 11380
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11380
ctccaacauc aaggaagaug gc                                                22


<210> 11381
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11381
ctccaacauc aaggaagaug g                                                 21


<210> 11382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11382
ctccaacauc aaggaagatg                                                   20


<210> 11383
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11383
ctccaacauc aaggaagat                                                    19


<210> 11384
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11384
ctccaacauc aaggaaga                                                     18


<210> 11385
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11385
ctccaacauc aaggaag                                                      17


<210> 11386
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 11386
tccaacauca aggaagaugg cauuucuag                                         29


<210> 11387
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 11387
tccaacauca aggaagaugg cauuucta                                          28


<210> 11388
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 11388
tccaacauca aggaagaugg cauuuct                                           27


<210> 11389
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 11389
tccaacauca aggaagaugg cauutc                                            26


<210> 11390
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11390
tccaacauca aggaagaugg cautt                                             25


<210> 11391
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11391
tccaacauca aggaagaugg catt                                              24


<210> 11392
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11392
tccaacauca aggaagaugg cat                                               23


<210> 11393
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11393
tccaacauca aggaagaugg ca                                                22


<210> 11394
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11394
tccaacauca aggaagaugg c                                                 21


<210> 11395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11395
tccaacauca aggaagaugg                                                   20


<210> 11396
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11396
tccaacauca aggaagatg                                                    19


<210> 11397
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11397
tccaacauca aggaagat                                                     18


<210> 11398
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11398
tccaacauca aggaaga                                                      17


<210> 11399
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11399
tccaacauca aggaag                                                       16


<210> 11400
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 11400
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 11401
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 11401
ccaacaucaa ggaagauggc auuucta                                           27


<210> 11402
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 11402
ccaacaucaa ggaagauggc auuuct                                            26


<210> 11403
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11403
ccaacaucaa ggaagauggc auutc                                             25


<210> 11404
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11404
ccaacaucaa ggaagauggc autt                                              24


<210> 11405
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11405
ccaacaucaa ggaagauggc att                                               23


<210> 11406
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11406
ccaacaucaa ggaagauggc at                                                22


<210> 11407
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11407
ccaacaucaa ggaagauggc a                                                 21


<210> 11408
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11408
ccaacaucaa ggaagauggc                                                   20


<210> 11409
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11409
ccaacaucaa ggaagaugg                                                    19


<210> 11410
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11410
ccaacaucaa ggaagatg                                                     18


<210> 11411
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11411
ccaacaucaa ggaagat                                                      17


<210> 11412
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11412
ccaacaucaa ggaaga                                                       16


<210> 11413
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11413
ccaacaucaa ggaag                                                        15


<210> 11414
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 11414
caacaucaag gaagauggca uuucuag                                           27


<210> 11415
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 11415
caacaucaag gaagauggca uuucta                                            26


<210> 11416
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11416
caacaucaag gaagauggca uuuct                                             25


<210> 11417
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11417
caacaucaag gaagauggca uutc                                              24


<210> 11418
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11418
caacaucaag gaagauggca utt                                               23


<210> 11419
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11419
caacaucaag gaagauggca tt                                                22


<210> 11420
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11420
caacaucaag gaagauggca t                                                 21


<210> 11421
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11421
caacaucaag gaagauggca                                                   20


<210> 11422
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11422
caacaucaag gaagauggc                                                    19


<210> 11423
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11423
caacaucaag gaagaugg                                                     18


<210> 11424
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11424
caacaucaag gaagatg                                                      17


<210> 11425
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11425
caacaucaag gaagat                                                       16


<210> 11426
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11426
caacaucaag gaaga                                                        15


<210> 11427
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11427
caacaucaag gaag                                                         14


<210> 11428
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 11428
aacaucaagg aagauggcau uucuag                                            26


<210> 11429
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11429
aacaucaagg aagauggcau uucta                                             25


<210> 11430
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11430
aacaucaagg aagauggcau uuct                                              24


<210> 11431
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11431
aacaucaagg aagauggcau utc                                               23


<210> 11432
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11432
aacaucaagg aagauggcau tt                                                22


<210> 11433
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11433
aacaucaagg aagauggcat t                                                 21


<210> 11434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11434
aacaucaagg aagauggcat                                                   20


<210> 11435
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11435
aacaucaagg aagauggca                                                    19


<210> 11436
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11436
aacaucaagg aagauggc                                                     18


<210> 11437
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11437
aacaucaagg aagaugg                                                      17


<210> 11438
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11438
aacaucaagg aagatg                                                       16


<210> 11439
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11439
aacaucaagg aagat                                                        15


<210> 11440
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11440
aacaucaagg aaga                                                         14


<210> 11441
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11441
aacaucaagg aag                                                          13


<210> 11442
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11442
acaucaagga agauggcauu ucuag                                             25


<210> 11443
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11443
acaucaagga agauggcauu ucta                                              24


<210> 11444
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11444
acaucaagga agauggcauu uct                                               23


<210> 11445
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11445
acaucaagga agauggcauu tc                                                22


<210> 11446
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11446
acaucaagga agauggcaut t                                                 21


<210> 11447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11447
acaucaagga agauggcatt                                                   20


<210> 11448
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11448
acaucaagga agauggcat                                                    19


<210> 11449
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11449
acaucaagga agauggca                                                     18


<210> 11450
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11450
acaucaagga agauggc                                                      17


<210> 11451
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11451
acaucaagga agaugg                                                       16


<210> 11452
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11452
acaucaagga agatg                                                        15


<210> 11453
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11453
acaucaagga agat                                                         14


<210> 11454
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11454
acaucaagga aga                                                          13


<210> 11455
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11455
acaucaagga ag                                                           12


<210> 11456
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11456
caucaaggaa gauggcauuu cuag                                              24


<210> 11457
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11457
caucaaggaa gauggcauuu cta                                               23


<210> 11458
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11458
caucaaggaa gauggcauuu ct                                                22


<210> 11459
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11459
caucaaggaa gauggcauut c                                                 21


<210> 11460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11460
caucaaggaa gauggcautt                                                   20


<210> 11461
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11461
caucaaggaa gauggcatt                                                    19


<210> 11462
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11462
caucaaggaa gauggcat                                                     18


<210> 11463
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11463
caucaaggaa gauggca                                                      17


<210> 11464
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11464
caucaaggaa gauggc                                                       16


<210> 11465
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11465
caucaaggaa gaugg                                                        15


<210> 11466
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11466
caucaaggaa gatg                                                         14


<210> 11467
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11467
caucaaggaa gat                                                          13


<210> 11468
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11468
caucaaggaa ga                                                           12


<210> 11469
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11469
caucaaggaa g                                                            11


<210> 11470
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11470
atcaaggaag auggcauuuc uag                                               23


<210> 11471
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11471
atcaaggaag auggcauuuc ta                                                22


<210> 11472
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11472
atcaaggaag auggcauuuc t                                                 21


<210> 11473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11473
atcaaggaag auggcauutc                                                   20


<210> 11474
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11474
atcaaggaag auggcautt                                                    19


<210> 11475
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11475
atcaaggaag auggcatt                                                     18


<210> 11476
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11476
atcaaggaag auggcat                                                      17


<210> 11477
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11477
atcaaggaag auggca                                                       16


<210> 11478
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11478
atcaaggaag auggc                                                        15


<210> 11479
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11479
atcaaggaag augg                                                         14


<210> 11480
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11480
atcaaggaag atg                                                          13


<210> 11481
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11481
atcaaggaag at                                                           12


<210> 11482
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11482
atcaaggaag a                                                            11


<210> 11483
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11483
atcaaggaag                                                              10


<210> 11484
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11484
ccagagcagg uaccuccaac atc                                               23


<210> 11485
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11485
ccagagcagg uaccucca                                                     18


<210> 11486
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11486
ccucugugau uuuauaacuu gat                                               23


<210> 11487
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11487
tcacccacca ucaccct                                                      17


<210> 11488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11488
tgauauccuc aaggucaccc                                                   20


<210> 11489
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11489
ctgcuugaug aucaucucgu tg                                                22


<210> 11490
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11490
ctgcuugaug aucauctc                                                     18


<210> 11491
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11491
gtuuccuuag uaaccacag                                                    19


<210> 11492
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11492
gtuuccuuag uaaccac                                                      17


<210> 11493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11493
tcaaggaaga uggcauuuct                                                   20


<210> 11494
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11494
tcaaggaaga uggcauuucu ag                                                22


<210> 11495
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11495
gguaaguucu guccaagc                                                     18


<210> 11496
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11496
gtaaguucug uccaagcc                                                     18


<210> 11497
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11497
agucgguaag uucugucc                                                     18


<210> 11498
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11498
ctguccaagc ccgguuga                                                     18


<210> 11499
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11499
taaguucugu ccaag                                                        15


<210> 11500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11500
ttcuguccaa gcccgguuga                                                   20


<210> 11501
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11501
ttcuguccaa gcccggutg                                                    19


<210> 11502
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11502
ttcuguccaa gcccggtt                                                     18


<210> 11503
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11503
ttcuguccaa gcccggt                                                      17


<210> 11504
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11504
ttcuguccaa gcccgg                                                       16


<210> 11505
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11505
ttcuguccaa gcccg                                                        15


<210> 11506
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11506
ttcuguccaa gccc                                                         14


<210> 11507
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11507
ttcuguccaa gcc                                                          13


<210> 11508
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11508
ttcuguccaa gc                                                           12


<210> 11509
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11509
ttcuguccaa g                                                            11


<210> 11510
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11510
ttcuguccaa                                                              10


<210> 11511
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11511
ttcugucca                                                                9


<210> 11512
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11512
ttcugucc                                                                 8


<210> 11513
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11513
tcuguccaag cccgguuga                                                    19


<210> 11514
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11514
tcuguccaag cccggutg                                                     18


<210> 11515
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11515
tcuguccaag cccggtt                                                      17


<210> 11516
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11516
tcuguccaag cccggt                                                       16


<210> 11517
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11517
tcuguccaag cccgg                                                        15


<210> 11518
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11518
tcuguccaag cccg                                                         14


<210> 11519
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11519
tcuguccaag ccc                                                          13


<210> 11520
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11520
tcuguccaag cc                                                           12


<210> 11521
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11521
tcuguccaag c                                                            11


<210> 11522
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11522
tcuguccaag                                                              10


<210> 11523
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11523
tcuguccaa                                                                9


<210> 11524
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11524
tcugucca                                                                 8


<210> 11525
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11525
ctguccaagc ccggutg                                                      17


<210> 11526
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11526
ctguccaagc ccggtt                                                       16


<210> 11527
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11527
ctguccaagc ccggt                                                        15


<210> 11528
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11528
ctguccaagc ccgg                                                         14


<210> 11529
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11529
ctguccaagc ccg                                                          13


<210> 11530
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11530
ctguccaagc cc                                                           12


<210> 11531
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11531
ctguccaagc c                                                            11


<210> 11532
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11532
ctguccaagc                                                              10


<210> 11533
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11533
ctguccaag                                                                9


<210> 11534
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11534
ctguccaa                                                                 8


<210> 11535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11535
gtucugucca agcccggutg                                                   20


<210> 11536
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11536
gtucugucca agcccggtt                                                    19


<210> 11537
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11537
gtucugucca agcccggt                                                     18


<210> 11538
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11538
gtucugucca agcccgg                                                      17


<210> 11539
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11539
gtucugucca agcccg                                                       16


<210> 11540
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11540
gtucugucca agccc                                                        15


<210> 11541
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11541
gtucugucca agcc                                                         14


<210> 11542
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11542
gtucugucca agc                                                          13


<210> 11543
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11543
gtucugucca ag                                                           12


<210> 11544
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11544
gtucugucca a                                                            11


<210> 11545
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11545
gtucugucca                                                              10


<210> 11546
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11546
gtucugucc                                                                9


<210> 11547
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11547
gtucugtc                                                                 8


<210> 11548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11548
aguucugucc aagcccggtt                                                   20


<210> 11549
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11549
aguucugucc aagcccggt                                                    19


<210> 11550
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11550
aguucugucc aagcccgg                                                     18


<210> 11551
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11551
aguucugucc aagcccg                                                      17


<210> 11552
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11552
aguucugucc aagccc                                                       16


<210> 11553
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11553
aguucugucc aagcc                                                        15


<210> 11554
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11554
aguucugucc aagc                                                         14


<210> 11555
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11555
aguucugucc aag                                                          13


<210> 11556
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11556
aguucugucc aa                                                           12


<210> 11557
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11557
aguucugucc a                                                            11


<210> 11558
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11558
aguucugucc                                                              10


<210> 11559
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11559
aguucugtc                                                                9


<210> 11560
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11560
aguucugt                                                                 8


<210> 11561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11561
aaguucuguc caagcccggt                                                   20


<210> 11562
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11562
aaguucuguc caagcccgg                                                    19


<210> 11563
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11563
aaguucuguc caagcccg                                                     18


<210> 11564
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11564
aaguucuguc caagccc                                                      17


<210> 11565
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11565
aaguucuguc caagcc                                                       16


<210> 11566
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11566
aaguucuguc caagc                                                        15


<210> 11567
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11567
aaguucuguc caag                                                         14


<210> 11568
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11568
aaguucuguc caa                                                          13


<210> 11569
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11569
aaguucuguc ca                                                           12


<210> 11570
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11570
aaguucuguc c                                                            11


<210> 11571
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11571
aaguucugtc                                                              10


<210> 11572
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11572
aaguucugt                                                                9


<210> 11573
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11573
aaguuctg                                                                 8


<210> 11574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11574
taaguucugu ccaagcccgg                                                   20


<210> 11575
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11575
taaguucugu ccaagcccg                                                    19


<210> 11576
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11576
taaguucugu ccaagccc                                                     18


<210> 11577
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11577
taaguucugu ccaagcc                                                      17


<210> 11578
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11578
taaguucugu ccaagc                                                       16


<210> 11579
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11579
taaguucugu ccaa                                                         14


<210> 11580
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11580
taaguucugu cca                                                          13


<210> 11581
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11581
taaguucugu cc                                                           12


<210> 11582
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11582
taaguucugt c                                                            11


<210> 11583
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11583
taaguucugt                                                              10


<210> 11584
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11584
taaguuctg                                                                9


<210> 11585
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11585
taaguuct                                                                 8


<210> 11586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11586
gtaaguucug uccaagcccg                                                   20


<210> 11587
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11587
gtaaguucug uccaagccc                                                    19


<210> 11588
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11588
gtaaguucug uccaagc                                                      17


<210> 11589
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11589
gtaaguucug uccaag                                                       16


<210> 11590
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11590
gtaaguucug uccaa                                                        15


<210> 11591
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11591
gtaaguucug ucca                                                         14


<210> 11592
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11592
gtaaguucug ucc                                                          13


<210> 11593
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11593
gtaaguucug tc                                                           12


<210> 11594
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11594
gtaaguucug t                                                            11


<210> 11595
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11595
gtaaguuctg                                                              10


<210> 11596
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11596
gtaaguuct                                                                9


<210> 11597
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11597
gtaagutc                                                                 8


<210> 11598
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11598
gguaaguucu guccaagccc                                                   20


<210> 11599
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11599
gguaaguucu guccaagcc                                                    19


<210> 11600
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11600
gguaaguucu guccaag                                                      17


<210> 11601
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11601
gguaaguucu guccaa                                                       16


<210> 11602
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11602
gguaaguucu gucca                                                        15


<210> 11603
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11603
gguaaguucu gucc                                                         14


<210> 11604
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11604
gguaaguucu gtc                                                          13


<210> 11605
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11605
gguaaguucu gt                                                           12


<210> 11606
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11606
gguaaguuct g                                                            11


<210> 11607
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11607
gguaaguuct                                                              10


<210> 11608
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11608
gguaagutc                                                                9


<210> 11609
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11609
gguaagtt                                                                 8


<210> 11610
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11610
cgguaaguuc uguccaagcc                                                   20


<210> 11611
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11611
cgguaaguuc uguccaagc                                                    19


<210> 11612
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11612
cgguaaguuc uguccaag                                                     18


<210> 11613
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11613
cgguaaguuc uguccaa                                                      17


<210> 11614
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11614
cgguaaguuc ugucca                                                       16


<210> 11615
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11615
cgguaaguuc ugucc                                                        15


<210> 11616
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11616
cgguaaguuc ugtc                                                         14


<210> 11617
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11617
cgguaaguuc ugt                                                          13


<210> 11618
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11618
cgguaaguuc tg                                                           12


<210> 11619
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11619
cgguaaguuc t                                                            11


<210> 11620
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11620
cgguaagutc                                                              10


<210> 11621
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11621
cgguaagtt                                                                9


<210> 11622
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11622
cgguaagt                                                                 8


<210> 11623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11623
tcgguaaguu cuguccaagc                                                   20


<210> 11624
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11624
tcgguaaguu cuguccaag                                                    19


<210> 11625
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11625
tcgguaaguu cuguccaa                                                     18


<210> 11626
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11626
tcgguaaguu cugucca                                                      17


<210> 11627
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11627
tcgguaaguu cugucc                                                       16


<210> 11628
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11628
tcgguaaguu cugtc                                                        15


<210> 11629
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11629
tcgguaaguu cugt                                                         14


<210> 11630
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11630
tcgguaaguu ctg                                                          13


<210> 11631
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11631
tcgguaaguu ct                                                           12


<210> 11632
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11632
tcgguaagut c                                                            11


<210> 11633
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11633
tcgguaagtt                                                              10


<210> 11634
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11634
tcgguaagt                                                                9


<210> 11635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11635
gtcgguaagu ucuguccaag                                                   20


<210> 11636
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11636
gtcgguaagu ucuguccaa                                                    19


<210> 11637
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11637
gtcgguaagu ucugucca                                                     18


<210> 11638
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11638
gtcgguaagu ucugucc                                                      17


<210> 11639
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11639
gtcgguaagu ucugtc                                                       16


<210> 11640
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11640
gtcgguaagu ucugt                                                        15


<210> 11641
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11641
gtcgguaagu uctg                                                         14


<210> 11642
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11642
gtcgguaagu uct                                                          13


<210> 11643
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11643
gtcgguaagu tc                                                           12


<210> 11644
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11644
gtcgguaagt t                                                            11


<210> 11645
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11645
gtcgguaagt                                                              10


<210> 11646
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11646
agucgguaag uucuguccaa                                                   20


<210> 11647
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11647
agucgguaag uucugucca                                                    19


<210> 11648
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11648
agucgguaag uucugtc                                                      17


<210> 11649
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11649
agucgguaag uucugt                                                       16


<210> 11650
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11650
agucgguaag uuctg                                                        15


<210> 11651
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11651
agucgguaag uuct                                                         14


<210> 11652
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11652
agucgguaag utc                                                          13


<210> 11653
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11653
agucgguaag tt                                                           12


<210> 11654
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11654
agucgguaag t                                                            11


<210> 11655
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11655
cagucgguaa guucugucca                                                   20


<210> 11656
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11656
cagucgguaa guucugucc                                                    19


<210> 11657
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11657
cagucgguaa guucugtc                                                     18


<210> 11658
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11658
cagucgguaa guucugt                                                      17


<210> 11659
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11659
cagucgguaa guuctg                                                       16


<210> 11660
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11660
cagucgguaa guuct                                                        15


<210> 11661
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11661
cagucgguaa gutc                                                         14


<210> 11662
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11662
cagucgguaa gtt                                                          13


<210> 11663
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11663
cagucgguaa gt                                                           12


<210> 11664
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11664
ccagucggua aguucugucc                                                   20


<210> 11665
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11665
ccagucggua aguucugtc                                                    19


<210> 11666
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11666
ccagucggua aguucugt                                                     18


<210> 11667
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11667
ccagucggua aguuctg                                                      17


<210> 11668
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11668
ccagucggua aguuct                                                       16


<210> 11669
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11669
ccagucggua agutc                                                        15


<210> 11670
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11670
ccagucggua agtt                                                         14


<210> 11671
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11671
ccagucggua agt                                                          13


<210> 11672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11672
gccagucggu aaguucugtc                                                   20


<210> 11673
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11673
gccagucggu aaguucugt                                                    19


<210> 11674
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11674
gccagucggu aaguuctg                                                     18


<210> 11675
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11675
gccagucggu aaguuct                                                      17


<210> 11676
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11676
gccagucggu aagutc                                                       16


<210> 11677
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11677
gccagucggu aagtt                                                        15


<210> 11678
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11678
gccagucggu aagt                                                         14


<210> 11679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11679
tcaaggaaga uggcauuuct                                                   20


<210> 11680
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11680
tcaaggaaga uggcauuucu ag                                                22


<210> 11681
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11681
tcaaggaaga uggcat                                                       16


<210> 11682
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11682
gaagauggca uuuct                                                        15


<210> 11683
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11683
tcaaggaaga uggcauuuct a                                                 21


<210> 11684
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11684
tcaaggaaga uggcauutc                                                    19


<210> 11685
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11685
tcaaggaaga uggcautt                                                     18


<210> 11686
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11686
tcaaggaaga uggcatt                                                      17


<210> 11687
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11687
tcaaggaaga uggca                                                        15


<210> 11688
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11688
tcaaggaaga uggc                                                         14


<210> 11689
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11689
tcaaggaaga ugg                                                          13


<210> 11690
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11690
tcaaggaaga tg                                                           12


<210> 11691
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11691
tcaaggaaga t                                                            11


<210> 11692
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11692
tcaaggaaga                                                              10


<210> 11693
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11693
tcaaggaag                                                                9


<210> 11694
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11694
caaggaagau ggcauuucua g                                                 21


<210> 11695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11695
caaggaagau ggcauuucta                                                   20


<210> 11696
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11696
caaggaagau ggcauuuct                                                    19


<210> 11697
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11697
caaggaagau ggcauutc                                                     18


<210> 11698
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11698
caaggaagau ggcautt                                                      17


<210> 11699
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11699
caaggaagau ggcatt                                                       16


<210> 11700
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11700
caaggaagau ggcat                                                        15


<210> 11701
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11701
caaggaagau ggca                                                         14


<210> 11702
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11702
caaggaagau ggc                                                          13


<210> 11703
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11703
caaggaagau gg                                                           12


<210> 11704
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11704
caaggaagat g                                                            11


<210> 11705
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11705
caaggaagat                                                              10


<210> 11706
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11706
caaggaaga                                                                9


<210> 11707
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11707
caaggaag                                                                 8


<210> 11708
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11708
aaggaagaug gcauuucuag                                                   20


<210> 11709
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11709
aaggaagaug gcauuucta                                                    19


<210> 11710
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11710
aaggaagaug gcauuuct                                                     18


<210> 11711
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11711
aaggaagaug gcauutc                                                      17


<210> 11712
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11712
aaggaagaug gcautt                                                       16


<210> 11713
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11713
aaggaagaug gcatt                                                        15


<210> 11714
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11714
aaggaagaug gcat                                                         14


<210> 11715
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11715
aaggaagaug gca                                                          13


<210> 11716
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11716
aaggaagaug gc                                                           12


<210> 11717
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11717
aaggaagaug g                                                            11


<210> 11718
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11718
aaggaagatg                                                              10


<210> 11719
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11719
aaggaagat                                                                9


<210> 11720
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11720
aaggaaga                                                                 8


<210> 11721
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11721
aggaagaugg cauuucuag                                                    19


<210> 11722
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11722
aggaagaugg cauuucta                                                     18


<210> 11723
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11723
aggaagaugg cauuuct                                                      17


<210> 11724
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11724
aggaagaugg cauutc                                                       16


<210> 11725
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11725
aggaagaugg cautt                                                        15


<210> 11726
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11726
aggaagaugg catt                                                         14


<210> 11727
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11727
aggaagaugg cat                                                          13


<210> 11728
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11728
aggaagaugg ca                                                           12


<210> 11729
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11729
aggaagaugg                                                              10


<210> 11730
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11730
aggaagatg                                                                9


<210> 11731
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11731
aggaagat                                                                 8


<210> 11732
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11732
ggaagauggc auuucuag                                                     18


<210> 11733
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11733
ggaagauggc auuucta                                                      17


<210> 11734
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11734
ggaagauggc auuuct                                                       16


<210> 11735
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11735
ggaagauggc auutc                                                        15


<210> 11736
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11736
ggaagauggc autt                                                         14


<210> 11737
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11737
ggaagauggc att                                                          13


<210> 11738
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11738
ggaagauggc at                                                           12


<210> 11739
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11739
ggaagauggc a                                                            11


<210> 11740
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11740
ggaagauggc                                                              10


<210> 11741
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11741
ggaagatg                                                                 8


<210> 11742
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11742
gaagauggca uuucuag                                                      17


<210> 11743
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11743
gaagauggca uuucta                                                       16


<210> 11744
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11744
gaagauggca uutc                                                         14


<210> 11745
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11745
gaagauggca utt                                                          13


<210> 11746
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11746
gaagauggca tt                                                           12


<210> 11747
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11747
gaagauggca t                                                            11


<210> 11748
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11748
gaagauggca                                                              10


<210> 11749
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11749
gaagauggc                                                                9


<210> 11750
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11750
gaagaugg                                                                 8


<210> 11751
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11751
aagauggcau uucuag                                                       16


<210> 11752
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11752
aagauggcau uucta                                                        15


<210> 11753
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11753
aagauggcau uuct                                                         14


<210> 11754
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11754
aagauggcau utc                                                          13


<210> 11755
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11755
aagauggcau tt                                                           12


<210> 11756
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11756
aagauggcat t                                                            11


<210> 11757
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11757
aagauggcat                                                              10


<210> 11758
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11758
aagauggca                                                                9


<210> 11759
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11759
aagauggc                                                                 8


<210> 11760
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11760
agauggcauu ucuag                                                        15


<210> 11761
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11761
agauggcauu ucta                                                         14


<210> 11762
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11762
agauggcauu uct                                                          13


<210> 11763
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11763
agauggcauu tc                                                           12


<210> 11764
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11764
agauggcaut t                                                            11


<210> 11765
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11765
agauggcatt                                                              10


<210> 11766
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 11766
agauggcat                                                                9


<210> 11767
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 11767
agauggca                                                                 8


<210> 11768
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 11768
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 11769
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 11769
ctccaacauc aaggaagaug gcauuucta                                         29


<210> 11770
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 11770
ctccaacauc aaggaagaug gcauuuct                                          28


<210> 11771
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 11771
ctccaacauc aaggaagaug gcauutc                                           27


<210> 11772
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 11772
ctccaacauc aaggaagaug gcautt                                            26


<210> 11773
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11773
ctccaacauc aaggaagaug gcatt                                             25


<210> 11774
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11774
ctccaacauc aaggaagaug gcat                                              24


<210> 11775
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11775
ctccaacauc aaggaagaug gca                                               23


<210> 11776
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11776
ctccaacauc aaggaagaug gc                                                22


<210> 11777
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11777
ctccaacauc aaggaagaug g                                                 21


<210> 11778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11778
ctccaacauc aaggaagatg                                                   20


<210> 11779
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11779
ctccaacauc aaggaagat                                                    19


<210> 11780
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11780
ctccaacauc aaggaaga                                                     18


<210> 11781
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11781
ctccaacauc aaggaag                                                      17


<210> 11782
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 11782
tccaacauca aggaagaugg cauuucuag                                         29


<210> 11783
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 11783
tccaacauca aggaagaugg cauuucta                                          28


<210> 11784
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 11784
tccaacauca aggaagaugg cauuuct                                           27


<210> 11785
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 11785
tccaacauca aggaagaugg cauutc                                            26


<210> 11786
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11786
tccaacauca aggaagaugg cautt                                             25


<210> 11787
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11787
tccaacauca aggaagaugg catt                                              24


<210> 11788
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11788
tccaacauca aggaagaugg cat                                               23


<210> 11789
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11789
tccaacauca aggaagaugg ca                                                22


<210> 11790
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11790
tccaacauca aggaagaugg c                                                 21


<210> 11791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11791
tccaacauca aggaagaugg                                                   20


<210> 11792
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11792
tccaacauca aggaagatg                                                    19


<210> 11793
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11793
tccaacauca aggaagat                                                     18


<210> 11794
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11794
tccaacauca aggaaga                                                      17


<210> 11795
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11795
tccaacauca aggaag                                                       16


<210> 11796
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 11796
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 11797
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 11797
ccaacaucaa ggaagauggc auuucta                                           27


<210> 11798
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 11798
ccaacaucaa ggaagauggc auuuct                                            26


<210> 11799
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11799
ccaacaucaa ggaagauggc auutc                                             25


<210> 11800
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11800
ccaacaucaa ggaagauggc autt                                              24


<210> 11801
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11801
ccaacaucaa ggaagauggc att                                               23


<210> 11802
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11802
ccaacaucaa ggaagauggc at                                                22


<210> 11803
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11803
ccaacaucaa ggaagauggc a                                                 21


<210> 11804
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11804
ccaacaucaa ggaagauggc                                                   20


<210> 11805
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11805
ccaacaucaa ggaagaugg                                                    19


<210> 11806
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11806
ccaacaucaa ggaagatg                                                     18


<210> 11807
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11807
ccaacaucaa ggaagat                                                      17


<210> 11808
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11808
ccaacaucaa ggaaga                                                       16


<210> 11809
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11809
ccaacaucaa ggaag                                                        15


<210> 11810
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 11810
caacaucaag gaagauggca uuucuag                                           27


<210> 11811
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 11811
caacaucaag gaagauggca uuucta                                            26


<210> 11812
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11812
caacaucaag gaagauggca uuuct                                             25


<210> 11813
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11813
caacaucaag gaagauggca uutc                                              24


<210> 11814
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11814
caacaucaag gaagauggca utt                                               23


<210> 11815
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11815
caacaucaag gaagauggca tt                                                22


<210> 11816
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11816
caacaucaag gaagauggca t                                                 21


<210> 11817
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11817
caacaucaag gaagauggca                                                   20


<210> 11818
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11818
caacaucaag gaagauggc                                                    19


<210> 11819
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11819
caacaucaag gaagaugg                                                     18


<210> 11820
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11820
caacaucaag gaagatg                                                      17


<210> 11821
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11821
caacaucaag gaagat                                                       16


<210> 11822
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11822
caacaucaag gaaga                                                        15


<210> 11823
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11823
caacaucaag gaag                                                         14


<210> 11824
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 11824
aacaucaagg aagauggcau uucuag                                            26


<210> 11825
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11825
aacaucaagg aagauggcau uucta                                             25


<210> 11826
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11826
aacaucaagg aagauggcau uuct                                              24


<210> 11827
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11827
aacaucaagg aagauggcau utc                                               23


<210> 11828
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11828
aacaucaagg aagauggcau tt                                                22


<210> 11829
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11829
aacaucaagg aagauggcat t                                                 21


<210> 11830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11830
aacaucaagg aagauggcat                                                   20


<210> 11831
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11831
aacaucaagg aagauggca                                                    19


<210> 11832
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11832
aacaucaagg aagauggc                                                     18


<210> 11833
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11833
aacaucaagg aagaugg                                                      17


<210> 11834
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11834
aacaucaagg aagatg                                                       16


<210> 11835
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11835
aacaucaagg aagat                                                        15


<210> 11836
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11836
aacaucaagg aaga                                                         14


<210> 11837
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11837
aacaucaagg aag                                                          13


<210> 11838
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 11838
acaucaagga agauggcauu ucuag                                             25


<210> 11839
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11839
acaucaagga agauggcauu ucta                                              24


<210> 11840
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11840
acaucaagga agauggcauu uct                                               23


<210> 11841
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11841
acaucaagga agauggcauu tc                                                22


<210> 11842
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11842
acaucaagga agauggcaut t                                                 21


<210> 11843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11843
acaucaagga agauggcatt                                                   20


<210> 11844
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11844
acaucaagga agauggcat                                                    19


<210> 11845
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11845
acaucaagga agauggca                                                     18


<210> 11846
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11846
acaucaagga agauggc                                                      17


<210> 11847
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11847
acaucaagga agaugg                                                       16


<210> 11848
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11848
acaucaagga agatg                                                        15


<210> 11849
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11849
acaucaagga agat                                                         14


<210> 11850
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11850
acaucaagga aga                                                          13


<210> 11851
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11851
acaucaagga ag                                                           12


<210> 11852
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 11852
caucaaggaa gauggcauuu cuag                                              24


<210> 11853
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11853
caucaaggaa gauggcauuu cta                                               23


<210> 11854
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11854
caucaaggaa gauggcauuu ct                                                22


<210> 11855
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11855
caucaaggaa gauggcauut c                                                 21


<210> 11856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11856
caucaaggaa gauggcautt                                                   20


<210> 11857
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11857
caucaaggaa gauggcatt                                                    19


<210> 11858
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11858
caucaaggaa gauggcat                                                     18


<210> 11859
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11859
caucaaggaa gauggca                                                      17


<210> 11860
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11860
caucaaggaa gauggc                                                       16


<210> 11861
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11861
caucaaggaa gaugg                                                        15


<210> 11862
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11862
caucaaggaa gatg                                                         14


<210> 11863
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11863
caucaaggaa gat                                                          13


<210> 11864
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11864
caucaaggaa ga                                                           12


<210> 11865
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11865
caucaaggaa g                                                            11


<210> 11866
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11866
atcaaggaag auggcauuuc uag                                               23


<210> 11867
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11867
atcaaggaag auggcauuuc ta                                                22


<210> 11868
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 11868
atcaaggaag auggcauuuc t                                                 21


<210> 11869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11869
atcaaggaag auggcauutc                                                   20


<210> 11870
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11870
atcaaggaag auggcautt                                                    19


<210> 11871
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11871
atcaaggaag auggcatt                                                     18


<210> 11872
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11872
atcaaggaag auggcat                                                      17


<210> 11873
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 11873
atcaaggaag auggca                                                       16


<210> 11874
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 11874
atcaaggaag auggc                                                        15


<210> 11875
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 11875
atcaaggaag augg                                                         14


<210> 11876
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 11876
atcaaggaag atg                                                          13


<210> 11877
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 11877
atcaaggaag at                                                           12


<210> 11878
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 11878
atcaaggaag a                                                            11


<210> 11879
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 11879
atcaaggaag                                                              10


<210> 11880
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11880
ccagagcagg uaccuccaac atc                                               23


<210> 11881
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11881
ccagagcagg uaccucca                                                     18


<210> 11882
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 11882
ccucugugau uuuauaacuu gat                                               23


<210> 11883
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11883
tcacccacca ucaccct                                                      17


<210> 11884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 11884
tgauauccuc aaggucaccc                                                   20


<210> 11885
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 11885
ctgcuugaug aucaucucgu tg                                                22


<210> 11886
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 11886
ctgcuugaug aucauctc                                                     18


<210> 11887
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 11887
gtuuccuuag uaaccacag                                                    19


<210> 11888
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 11888
gtuuccuuag uaaccac                                                      17


<210> 11889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11889
tcaaggaaga uggcauuuct                                                   20


<210> 11890
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11890
tcaaggaaga uggcauuucu ag                                                22


<210> 11891
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11891
gguaaguucu guccaagc                                                     18


<210> 11892
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11892
gtaaguucug uccaagcc                                                     18


<210> 11893
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11893
agucgguaag uucugucc                                                     18


<210> 11894
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11894
ctguccaagc ccgguuga                                                     18


<210> 11895
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11895
taaguucugu ccaag                                                        15


<210> 11896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11896
ttcuguccaa gcccgguuga                                                   20


<210> 11897
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11897
ttcuguccaa gcccggutg                                                    19


<210> 11898
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11898
ttcuguccaa gcccggtt                                                     18


<210> 11899
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11899
ttcuguccaa gcccggt                                                      17


<210> 11900
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11900
ttcuguccaa gcccgg                                                       16


<210> 11901
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11901
ttcuguccaa gcccg                                                        15


<210> 11902
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11902
ttcuguccaa gccc                                                         14


<210> 11903
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11903
ttcuguccaa gcc                                                          13


<210> 11904
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11904
ttcuguccaa gc                                                           12


<210> 11905
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11905
ttcuguccaa g                                                            11


<210> 11906
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11906
ttcuguccaa                                                              10


<210> 11907
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11907
ttcugucca                                                                9


<210> 11908
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11908
ttcugucc                                                                 8


<210> 11909
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11909
tcuguccaag cccgguuga                                                    19


<210> 11910
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11910
tcuguccaag cccggutg                                                     18


<210> 11911
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11911
tcuguccaag cccggtt                                                      17


<210> 11912
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11912
tcuguccaag cccggt                                                       16


<210> 11913
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11913
tcuguccaag cccgg                                                        15


<210> 11914
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11914
tcuguccaag cccg                                                         14


<210> 11915
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11915
tcuguccaag ccc                                                          13


<210> 11916
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11916
tcuguccaag cc                                                           12


<210> 11917
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11917
tcuguccaag c                                                            11


<210> 11918
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11918
tcuguccaag                                                              10


<210> 11919
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11919
tcuguccaa                                                                9


<210> 11920
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11920
tcugucca                                                                 8


<210> 11921
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11921
ctguccaagc ccggutg                                                      17


<210> 11922
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11922
ctguccaagc ccggtt                                                       16


<210> 11923
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11923
ctguccaagc ccggt                                                        15


<210> 11924
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11924
ctguccaagc ccgg                                                         14


<210> 11925
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11925
ctguccaagc ccg                                                          13


<210> 11926
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11926
ctguccaagc cc                                                           12


<210> 11927
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11927
ctguccaagc c                                                            11


<210> 11928
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11928
ctguccaagc                                                              10


<210> 11929
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11929
ctguccaag                                                                9


<210> 11930
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11930
ctguccaa                                                                 8


<210> 11931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11931
gtucugucca agcccggutg                                                   20


<210> 11932
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11932
gtucugucca agcccggtt                                                    19


<210> 11933
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11933
gtucugucca agcccggt                                                     18


<210> 11934
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11934
gtucugucca agcccgg                                                      17


<210> 11935
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11935
gtucugucca agcccg                                                       16


<210> 11936
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11936
gtucugucca agccc                                                        15


<210> 11937
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11937
gtucugucca agcc                                                         14


<210> 11938
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11938
gtucugucca agc                                                          13


<210> 11939
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11939
gtucugucca ag                                                           12


<210> 11940
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11940
gtucugucca a                                                            11


<210> 11941
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11941
gtucugucca                                                              10


<210> 11942
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11942
gtucugucc                                                                9


<210> 11943
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11943
gtucugtc                                                                 8


<210> 11944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11944
aguucugucc aagcccggtt                                                   20


<210> 11945
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11945
aguucugucc aagcccggt                                                    19


<210> 11946
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11946
aguucugucc aagcccgg                                                     18


<210> 11947
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11947
aguucugucc aagcccg                                                      17


<210> 11948
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11948
aguucugucc aagccc                                                       16


<210> 11949
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11949
aguucugucc aagcc                                                        15


<210> 11950
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11950
aguucugucc aagc                                                         14


<210> 11951
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11951
aguucugucc aag                                                          13


<210> 11952
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11952
aguucugucc aa                                                           12


<210> 11953
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11953
aguucugucc a                                                            11


<210> 11954
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11954
aguucugucc                                                              10


<210> 11955
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11955
aguucugtc                                                                9


<210> 11956
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11956
aguucugt                                                                 8


<210> 11957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11957
aaguucuguc caagcccggt                                                   20


<210> 11958
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11958
aaguucuguc caagcccgg                                                    19


<210> 11959
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11959
aaguucuguc caagcccg                                                     18


<210> 11960
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11960
aaguucuguc caagccc                                                      17


<210> 11961
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11961
aaguucuguc caagcc                                                       16


<210> 11962
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11962
aaguucuguc caagc                                                        15


<210> 11963
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11963
aaguucuguc caag                                                         14


<210> 11964
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11964
aaguucuguc caa                                                          13


<210> 11965
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11965
aaguucuguc ca                                                           12


<210> 11966
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11966
aaguucuguc c                                                            11


<210> 11967
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11967
aaguucugtc                                                              10


<210> 11968
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11968
aaguucugt                                                                9


<210> 11969
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11969
aaguuctg                                                                 8


<210> 11970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11970
taaguucugu ccaagcccgg                                                   20


<210> 11971
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11971
taaguucugu ccaagcccg                                                    19


<210> 11972
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11972
taaguucugu ccaagccc                                                     18


<210> 11973
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11973
taaguucugu ccaagcc                                                      17


<210> 11974
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11974
taaguucugu ccaagc                                                       16


<210> 11975
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11975
taaguucugu ccaa                                                         14


<210> 11976
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11976
taaguucugu cca                                                          13


<210> 11977
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11977
taaguucugu cc                                                           12


<210> 11978
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11978
taaguucugt c                                                            11


<210> 11979
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11979
taaguucugt                                                              10


<210> 11980
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11980
taaguuctg                                                                9


<210> 11981
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11981
taaguuct                                                                 8


<210> 11982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11982
gtaaguucug uccaagcccg                                                   20


<210> 11983
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11983
gtaaguucug uccaagccc                                                    19


<210> 11984
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11984
gtaaguucug uccaagc                                                      17


<210> 11985
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11985
gtaaguucug uccaag                                                       16


<210> 11986
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11986
gtaaguucug uccaa                                                        15


<210> 11987
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11987
gtaaguucug ucca                                                         14


<210> 11988
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11988
gtaaguucug ucc                                                          13


<210> 11989
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11989
gtaaguucug tc                                                           12


<210> 11990
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11990
gtaaguucug t                                                            11


<210> 11991
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11991
gtaaguuctg                                                              10


<210> 11992
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11992
gtaaguuct                                                                9


<210> 11993
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11993
gtaagutc                                                                 8


<210> 11994
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11994
gguaaguucu guccaagccc                                                   20


<210> 11995
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11995
gguaaguucu guccaagcc                                                    19


<210> 11996
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11996
gguaaguucu guccaag                                                      17


<210> 11997
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11997
gguaaguucu guccaa                                                       16


<210> 11998
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11998
gguaaguucu gucca                                                        15


<210> 11999
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 11999
gguaaguucu gucc                                                         14


<210> 12000
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12000
gguaaguucu gtc                                                          13


<210> 12001
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12001
gguaaguucu gt                                                           12


<210> 12002
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12002
gguaaguuct g                                                            11


<210> 12003
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12003
gguaaguuct                                                              10


<210> 12004
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12004
gguaagutc                                                                9


<210> 12005
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12005
gguaagtt                                                                 8


<210> 12006
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12006
cgguaaguuc uguccaagcc                                                   20


<210> 12007
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12007
cgguaaguuc uguccaagc                                                    19


<210> 12008
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12008
cgguaaguuc uguccaag                                                     18


<210> 12009
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12009
cgguaaguuc uguccaa                                                      17


<210> 12010
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12010
cgguaaguuc ugucca                                                       16


<210> 12011
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12011
cgguaaguuc ugucc                                                        15


<210> 12012
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12012
cgguaaguuc ugtc                                                         14


<210> 12013
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12013
cgguaaguuc ugt                                                          13


<210> 12014
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12014
cgguaaguuc tg                                                           12


<210> 12015
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12015
cgguaaguuc t                                                            11


<210> 12016
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12016
cgguaagutc                                                              10


<210> 12017
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12017
cgguaagtt                                                                9


<210> 12018
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12018
cgguaagt                                                                 8


<210> 12019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12019
tcgguaaguu cuguccaagc                                                   20


<210> 12020
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12020
tcgguaaguu cuguccaag                                                    19


<210> 12021
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12021
tcgguaaguu cuguccaa                                                     18


<210> 12022
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12022
tcgguaaguu cugucca                                                      17


<210> 12023
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12023
tcgguaaguu cugucc                                                       16


<210> 12024
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12024
tcgguaaguu cugtc                                                        15


<210> 12025
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12025
tcgguaaguu cugt                                                         14


<210> 12026
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12026
tcgguaaguu ctg                                                          13


<210> 12027
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12027
tcgguaaguu ct                                                           12


<210> 12028
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12028
tcgguaagut c                                                            11


<210> 12029
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12029
tcgguaagtt                                                              10


<210> 12030
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12030
tcgguaagt                                                                9


<210> 12031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12031
gtcgguaagu ucuguccaag                                                   20


<210> 12032
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12032
gtcgguaagu ucuguccaa                                                    19


<210> 12033
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12033
gtcgguaagu ucugucca                                                     18


<210> 12034
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12034
gtcgguaagu ucugucc                                                      17


<210> 12035
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12035
gtcgguaagu ucugtc                                                       16


<210> 12036
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12036
gtcgguaagu ucugt                                                        15


<210> 12037
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12037
gtcgguaagu uctg                                                         14


<210> 12038
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12038
gtcgguaagu uct                                                          13


<210> 12039
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12039
gtcgguaagu tc                                                           12


<210> 12040
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12040
gtcgguaagt t                                                            11


<210> 12041
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12041
gtcgguaagt                                                              10


<210> 12042
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12042
agucgguaag uucuguccaa                                                   20


<210> 12043
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12043
agucgguaag uucugucca                                                    19


<210> 12044
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12044
agucgguaag uucugtc                                                      17


<210> 12045
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12045
agucgguaag uucugt                                                       16


<210> 12046
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12046
agucgguaag uuctg                                                        15


<210> 12047
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12047
agucgguaag uuct                                                         14


<210> 12048
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12048
agucgguaag utc                                                          13


<210> 12049
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12049
agucgguaag tt                                                           12


<210> 12050
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12050
agucgguaag t                                                            11


<210> 12051
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12051
cagucgguaa guucugucca                                                   20


<210> 12052
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12052
cagucgguaa guucugucc                                                    19


<210> 12053
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12053
cagucgguaa guucugtc                                                     18


<210> 12054
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12054
cagucgguaa guucugt                                                      17


<210> 12055
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12055
cagucgguaa guuctg                                                       16


<210> 12056
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12056
cagucgguaa guuct                                                        15


<210> 12057
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12057
cagucgguaa gutc                                                         14


<210> 12058
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12058
cagucgguaa gtt                                                          13


<210> 12059
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12059
cagucgguaa gt                                                           12


<210> 12060
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12060
ccagucggua aguucugucc                                                   20


<210> 12061
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12061
ccagucggua aguucugtc                                                    19


<210> 12062
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12062
ccagucggua aguucugt                                                     18


<210> 12063
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12063
ccagucggua aguuctg                                                      17


<210> 12064
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12064
ccagucggua aguuct                                                       16


<210> 12065
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12065
ccagucggua agutc                                                        15


<210> 12066
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12066
ccagucggua agtt                                                         14


<210> 12067
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12067
ccagucggua agt                                                          13


<210> 12068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12068
gccagucggu aaguucugtc                                                   20


<210> 12069
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12069
gccagucggu aaguucugt                                                    19


<210> 12070
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12070
gccagucggu aaguuctg                                                     18


<210> 12071
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12071
gccagucggu aaguuct                                                      17


<210> 12072
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12072
gccagucggu aagutc                                                       16


<210> 12073
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12073
gccagucggu aagtt                                                        15


<210> 12074
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12074
gccagucggu aagt                                                         14


<210> 12075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12075
tcaaggaaga uggcauuuct                                                   20


<210> 12076
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12076
tcaaggaaga uggcauuucu ag                                                22


<210> 12077
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12077
tcaaggaaga uggcat                                                       16


<210> 12078
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12078
gaagauggca uuuct                                                        15


<210> 12079
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12079
tcaaggaaga uggcauuuct a                                                 21


<210> 12080
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12080
tcaaggaaga uggcauutc                                                    19


<210> 12081
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12081
tcaaggaaga uggcautt                                                     18


<210> 12082
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12082
tcaaggaaga uggcatt                                                      17


<210> 12083
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12083
tcaaggaaga uggca                                                        15


<210> 12084
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12084
tcaaggaaga uggc                                                         14


<210> 12085
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12085
tcaaggaaga ugg                                                          13


<210> 12086
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12086
tcaaggaaga tg                                                           12


<210> 12087
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12087
tcaaggaaga t                                                            11


<210> 12088
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12088
tcaaggaaga                                                              10


<210> 12089
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12089
tcaaggaag                                                                9


<210> 12090
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12090
caaggaagau ggcauuucua g                                                 21


<210> 12091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12091
caaggaagau ggcauuucta                                                   20


<210> 12092
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12092
caaggaagau ggcauuuct                                                    19


<210> 12093
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12093
caaggaagau ggcauutc                                                     18


<210> 12094
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12094
caaggaagau ggcautt                                                      17


<210> 12095
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12095
caaggaagau ggcatt                                                       16


<210> 12096
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12096
caaggaagau ggcat                                                        15


<210> 12097
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12097
caaggaagau ggca                                                         14


<210> 12098
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12098
caaggaagau ggc                                                          13


<210> 12099
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12099
caaggaagau gg                                                           12


<210> 12100
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12100
caaggaagat g                                                            11


<210> 12101
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12101
caaggaagat                                                              10


<210> 12102
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12102
caaggaaga                                                                9


<210> 12103
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12103
caaggaag                                                                 8


<210> 12104
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12104
aaggaagaug gcauuucuag                                                   20


<210> 12105
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12105
aaggaagaug gcauuucta                                                    19


<210> 12106
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12106
aaggaagaug gcauuuct                                                     18


<210> 12107
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12107
aaggaagaug gcauutc                                                      17


<210> 12108
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12108
aaggaagaug gcautt                                                       16


<210> 12109
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12109
aaggaagaug gcatt                                                        15


<210> 12110
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12110
aaggaagaug gcat                                                         14


<210> 12111
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12111
aaggaagaug gca                                                          13


<210> 12112
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12112
aaggaagaug gc                                                           12


<210> 12113
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12113
aaggaagaug g                                                            11


<210> 12114
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12114
aaggaagatg                                                              10


<210> 12115
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12115
aaggaagat                                                                9


<210> 12116
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12116
aaggaaga                                                                 8


<210> 12117
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12117
aggaagaugg cauuucuag                                                    19


<210> 12118
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12118
aggaagaugg cauuucta                                                     18


<210> 12119
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12119
aggaagaugg cauuuct                                                      17


<210> 12120
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12120
aggaagaugg cauutc                                                       16


<210> 12121
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12121
aggaagaugg cautt                                                        15


<210> 12122
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12122
aggaagaugg catt                                                         14


<210> 12123
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12123
aggaagaugg cat                                                          13


<210> 12124
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12124
aggaagaugg ca                                                           12


<210> 12125
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12125
aggaagaugg                                                              10


<210> 12126
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12126
aggaagatg                                                                9


<210> 12127
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12127
aggaagat                                                                 8


<210> 12128
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12128
ggaagauggc auuucuag                                                     18


<210> 12129
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12129
ggaagauggc auuucta                                                      17


<210> 12130
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12130
ggaagauggc auuuct                                                       16


<210> 12131
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12131
ggaagauggc auutc                                                        15


<210> 12132
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12132
ggaagauggc autt                                                         14


<210> 12133
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12133
ggaagauggc att                                                          13


<210> 12134
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12134
ggaagauggc at                                                           12


<210> 12135
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12135
ggaagauggc a                                                            11


<210> 12136
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12136
ggaagauggc                                                              10


<210> 12137
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12137
ggaagatg                                                                 8


<210> 12138
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12138
gaagauggca uuucuag                                                      17


<210> 12139
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12139
gaagauggca uuucta                                                       16


<210> 12140
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12140
gaagauggca uutc                                                         14


<210> 12141
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12141
gaagauggca utt                                                          13


<210> 12142
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12142
gaagauggca tt                                                           12


<210> 12143
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12143
gaagauggca t                                                            11


<210> 12144
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12144
gaagauggca                                                              10


<210> 12145
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12145
gaagauggc                                                                9


<210> 12146
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12146
gaagaugg                                                                 8


<210> 12147
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12147
aagauggcau uucuag                                                       16


<210> 12148
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12148
aagauggcau uucta                                                        15


<210> 12149
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12149
aagauggcau uuct                                                         14


<210> 12150
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12150
aagauggcau utc                                                          13


<210> 12151
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12151
aagauggcau tt                                                           12


<210> 12152
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12152
aagauggcat t                                                            11


<210> 12153
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12153
aagauggcat                                                              10


<210> 12154
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12154
aagauggca                                                                9


<210> 12155
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12155
aagauggc                                                                 8


<210> 12156
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12156
agauggcauu ucuag                                                        15


<210> 12157
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12157
agauggcauu ucta                                                         14


<210> 12158
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12158
agauggcauu uct                                                          13


<210> 12159
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12159
agauggcauu tc                                                           12


<210> 12160
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12160
agauggcaut t                                                            11


<210> 12161
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12161
agauggcatt                                                              10


<210> 12162
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12162
agauggcat                                                                9


<210> 12163
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12163
agauggca                                                                 8


<210> 12164
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12164
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 12165
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12165
ctccaacauc aaggaagaug gcauuucta                                         29


<210> 12166
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12166
ctccaacauc aaggaagaug gcauuuct                                          28


<210> 12167
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12167
ctccaacauc aaggaagaug gcauutc                                           27


<210> 12168
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12168
ctccaacauc aaggaagaug gcautt                                            26


<210> 12169
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12169
ctccaacauc aaggaagaug gcatt                                             25


<210> 12170
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12170
ctccaacauc aaggaagaug gcat                                              24


<210> 12171
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12171
ctccaacauc aaggaagaug gca                                               23


<210> 12172
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12172
ctccaacauc aaggaagaug gc                                                22


<210> 12173
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12173
ctccaacauc aaggaagaug g                                                 21


<210> 12174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12174
ctccaacauc aaggaagatg                                                   20


<210> 12175
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12175
ctccaacauc aaggaagat                                                    19


<210> 12176
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12176
ctccaacauc aaggaaga                                                     18


<210> 12177
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12177
ctccaacauc aaggaag                                                      17


<210> 12178
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12178
tccaacauca aggaagaugg cauuucuag                                         29


<210> 12179
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12179
tccaacauca aggaagaugg cauuucta                                          28


<210> 12180
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12180
tccaacauca aggaagaugg cauuuct                                           27


<210> 12181
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12181
tccaacauca aggaagaugg cauutc                                            26


<210> 12182
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12182
tccaacauca aggaagaugg cautt                                             25


<210> 12183
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12183
tccaacauca aggaagaugg catt                                              24


<210> 12184
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12184
tccaacauca aggaagaugg cat                                               23


<210> 12185
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12185
tccaacauca aggaagaugg ca                                                22


<210> 12186
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12186
tccaacauca aggaagaugg c                                                 21


<210> 12187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12187
tccaacauca aggaagaugg                                                   20


<210> 12188
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12188
tccaacauca aggaagatg                                                    19


<210> 12189
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12189
tccaacauca aggaagat                                                     18


<210> 12190
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12190
tccaacauca aggaaga                                                      17


<210> 12191
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12191
tccaacauca aggaag                                                       16


<210> 12192
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12192
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 12193
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12193
ccaacaucaa ggaagauggc auuucta                                           27


<210> 12194
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12194
ccaacaucaa ggaagauggc auuuct                                            26


<210> 12195
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12195
ccaacaucaa ggaagauggc auutc                                             25


<210> 12196
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12196
ccaacaucaa ggaagauggc autt                                              24


<210> 12197
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12197
ccaacaucaa ggaagauggc att                                               23


<210> 12198
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12198
ccaacaucaa ggaagauggc at                                                22


<210> 12199
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12199
ccaacaucaa ggaagauggc a                                                 21


<210> 12200
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12200
ccaacaucaa ggaagauggc                                                   20


<210> 12201
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12201
ccaacaucaa ggaagaugg                                                    19


<210> 12202
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12202
ccaacaucaa ggaagatg                                                     18


<210> 12203
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12203
ccaacaucaa ggaagat                                                      17


<210> 12204
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12204
ccaacaucaa ggaaga                                                       16


<210> 12205
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12205
ccaacaucaa ggaag                                                        15


<210> 12206
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12206
caacaucaag gaagauggca uuucuag                                           27


<210> 12207
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12207
caacaucaag gaagauggca uuucta                                            26


<210> 12208
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12208
caacaucaag gaagauggca uuuct                                             25


<210> 12209
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12209
caacaucaag gaagauggca uutc                                              24


<210> 12210
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12210
caacaucaag gaagauggca utt                                               23


<210> 12211
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12211
caacaucaag gaagauggca tt                                                22


<210> 12212
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12212
caacaucaag gaagauggca t                                                 21


<210> 12213
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12213
caacaucaag gaagauggca                                                   20


<210> 12214
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12214
caacaucaag gaagauggc                                                    19


<210> 12215
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12215
caacaucaag gaagaugg                                                     18


<210> 12216
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12216
caacaucaag gaagatg                                                      17


<210> 12217
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12217
caacaucaag gaagat                                                       16


<210> 12218
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12218
caacaucaag gaaga                                                        15


<210> 12219
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12219
caacaucaag gaag                                                         14


<210> 12220
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12220
aacaucaagg aagauggcau uucuag                                            26


<210> 12221
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12221
aacaucaagg aagauggcau uucta                                             25


<210> 12222
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12222
aacaucaagg aagauggcau uuct                                              24


<210> 12223
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12223
aacaucaagg aagauggcau utc                                               23


<210> 12224
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12224
aacaucaagg aagauggcau tt                                                22


<210> 12225
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12225
aacaucaagg aagauggcat t                                                 21


<210> 12226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12226
aacaucaagg aagauggcat                                                   20


<210> 12227
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12227
aacaucaagg aagauggca                                                    19


<210> 12228
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12228
aacaucaagg aagauggc                                                     18


<210> 12229
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12229
aacaucaagg aagaugg                                                      17


<210> 12230
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12230
aacaucaagg aagatg                                                       16


<210> 12231
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12231
aacaucaagg aagat                                                        15


<210> 12232
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12232
aacaucaagg aaga                                                         14


<210> 12233
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12233
aacaucaagg aag                                                          13


<210> 12234
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12234
acaucaagga agauggcauu ucuag                                             25


<210> 12235
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12235
acaucaagga agauggcauu ucta                                              24


<210> 12236
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12236
acaucaagga agauggcauu uct                                               23


<210> 12237
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12237
acaucaagga agauggcauu tc                                                22


<210> 12238
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12238
acaucaagga agauggcaut t                                                 21


<210> 12239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12239
acaucaagga agauggcatt                                                   20


<210> 12240
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12240
acaucaagga agauggcat                                                    19


<210> 12241
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12241
acaucaagga agauggca                                                     18


<210> 12242
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12242
acaucaagga agauggc                                                      17


<210> 12243
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12243
acaucaagga agaugg                                                       16


<210> 12244
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12244
acaucaagga agatg                                                        15


<210> 12245
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12245
acaucaagga agat                                                         14


<210> 12246
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12246
acaucaagga aga                                                          13


<210> 12247
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12247
acaucaagga ag                                                           12


<210> 12248
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12248
caucaaggaa gauggcauuu cuag                                              24


<210> 12249
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12249
caucaaggaa gauggcauuu cta                                               23


<210> 12250
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12250
caucaaggaa gauggcauuu ct                                                22


<210> 12251
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12251
caucaaggaa gauggcauut c                                                 21


<210> 12252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12252
caucaaggaa gauggcautt                                                   20


<210> 12253
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12253
caucaaggaa gauggcatt                                                    19


<210> 12254
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12254
caucaaggaa gauggcat                                                     18


<210> 12255
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12255
caucaaggaa gauggca                                                      17


<210> 12256
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12256
caucaaggaa gauggc                                                       16


<210> 12257
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12257
caucaaggaa gaugg                                                        15


<210> 12258
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12258
caucaaggaa gatg                                                         14


<210> 12259
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12259
caucaaggaa gat                                                          13


<210> 12260
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12260
caucaaggaa ga                                                           12


<210> 12261
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12261
caucaaggaa g                                                            11


<210> 12262
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12262
atcaaggaag auggcauuuc uag                                               23


<210> 12263
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12263
atcaaggaag auggcauuuc ta                                                22


<210> 12264
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12264
atcaaggaag auggcauuuc t                                                 21


<210> 12265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12265
atcaaggaag auggcauutc                                                   20


<210> 12266
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12266
atcaaggaag auggcautt                                                    19


<210> 12267
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12267
atcaaggaag auggcatt                                                     18


<210> 12268
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12268
atcaaggaag auggcat                                                      17


<210> 12269
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12269
atcaaggaag auggca                                                       16


<210> 12270
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12270
atcaaggaag auggc                                                        15


<210> 12271
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12271
atcaaggaag augg                                                         14


<210> 12272
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12272
atcaaggaag atg                                                          13


<210> 12273
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12273
atcaaggaag at                                                           12


<210> 12274
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12274
atcaaggaag a                                                            11


<210> 12275
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12275
atcaaggaag                                                              10


<210> 12276
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12276
ccagagcagg uaccuccaac atc                                               23


<210> 12277
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12277
ccagagcagg uaccucca                                                     18


<210> 12278
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12278
ccucugugau uuuauaacuu gat                                               23


<210> 12279
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12279
tcacccacca ucaccct                                                      17


<210> 12280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12280
tgauauccuc aaggucaccc                                                   20


<210> 12281
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12281
ctgcuugaug aucaucucgu tg                                                22


<210> 12282
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12282
ctgcuugaug aucauctc                                                     18


<210> 12283
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12283
gtuuccuuag uaaccacag                                                    19


<210> 12284
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12284
gtuuccuuag uaaccac                                                      17


<210> 12285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12285
tcaaggaaga uggcauuuct                                                   20


<210> 12286
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12286
tcaaggaaga uggcauuucu ag                                                22


<210> 12287
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12287
gguaaguucu guccaagc                                                     18


<210> 12288
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12288
gtaaguucug uccaagcc                                                     18


<210> 12289
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12289
agucgguaag uucugucc                                                     18


<210> 12290
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12290
ctguccaagc ccgguuga                                                     18


<210> 12291
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12291
taaguucugu ccaag                                                        15


<210> 12292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12292
ttcuguccaa gcccgguuga                                                   20


<210> 12293
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12293
ttcuguccaa gcccggutg                                                    19


<210> 12294
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12294
ttcuguccaa gcccggtt                                                     18


<210> 12295
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12295
ttcuguccaa gcccggt                                                      17


<210> 12296
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12296
ttcuguccaa gcccgg                                                       16


<210> 12297
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12297
ttcuguccaa gcccg                                                        15


<210> 12298
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12298
ttcuguccaa gccc                                                         14


<210> 12299
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12299
ttcuguccaa gcc                                                          13


<210> 12300
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12300
ttcuguccaa gc                                                           12


<210> 12301
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12301
ttcuguccaa g                                                            11


<210> 12302
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12302
ttcuguccaa                                                              10


<210> 12303
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12303
ttcugucca                                                                9


<210> 12304
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12304
ttcugucc                                                                 8


<210> 12305
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12305
tcuguccaag cccgguuga                                                    19


<210> 12306
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12306
tcuguccaag cccggutg                                                     18


<210> 12307
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12307
tcuguccaag cccggtt                                                      17


<210> 12308
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12308
tcuguccaag cccggt                                                       16


<210> 12309
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12309
tcuguccaag cccgg                                                        15


<210> 12310
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12310
tcuguccaag cccg                                                         14


<210> 12311
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12311
tcuguccaag ccc                                                          13


<210> 12312
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12312
tcuguccaag cc                                                           12


<210> 12313
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12313
tcuguccaag c                                                            11


<210> 12314
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12314
tcuguccaag                                                              10


<210> 12315
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12315
tcuguccaa                                                                9


<210> 12316
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12316
tcugucca                                                                 8


<210> 12317
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12317
ctguccaagc ccggutg                                                      17


<210> 12318
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12318
ctguccaagc ccggtt                                                       16


<210> 12319
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12319
ctguccaagc ccggt                                                        15


<210> 12320
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12320
ctguccaagc ccgg                                                         14


<210> 12321
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12321
ctguccaagc ccg                                                          13


<210> 12322
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12322
ctguccaagc cc                                                           12


<210> 12323
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12323
ctguccaagc c                                                            11


<210> 12324
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12324
ctguccaagc                                                              10


<210> 12325
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12325
ctguccaag                                                                9


<210> 12326
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12326
ctguccaa                                                                 8


<210> 12327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12327
gtucugucca agcccggutg                                                   20


<210> 12328
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12328
gtucugucca agcccggtt                                                    19


<210> 12329
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12329
gtucugucca agcccggt                                                     18


<210> 12330
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12330
gtucugucca agcccgg                                                      17


<210> 12331
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12331
gtucugucca agcccg                                                       16


<210> 12332
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12332
gtucugucca agccc                                                        15


<210> 12333
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12333
gtucugucca agcc                                                         14


<210> 12334
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12334
gtucugucca agc                                                          13


<210> 12335
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12335
gtucugucca ag                                                           12


<210> 12336
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12336
gtucugucca a                                                            11


<210> 12337
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12337
gtucugucca                                                              10


<210> 12338
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12338
gtucugucc                                                                9


<210> 12339
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12339
gtucugtc                                                                 8


<210> 12340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12340
aguucugucc aagcccggtt                                                   20


<210> 12341
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12341
aguucugucc aagcccggt                                                    19


<210> 12342
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12342
aguucugucc aagcccgg                                                     18


<210> 12343
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12343
aguucugucc aagcccg                                                      17


<210> 12344
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12344
aguucugucc aagccc                                                       16


<210> 12345
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12345
aguucugucc aagcc                                                        15


<210> 12346
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12346
aguucugucc aagc                                                         14


<210> 12347
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12347
aguucugucc aag                                                          13


<210> 12348
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12348
aguucugucc aa                                                           12


<210> 12349
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12349
aguucugucc a                                                            11


<210> 12350
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12350
aguucugucc                                                              10


<210> 12351
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12351
aguucugtc                                                                9


<210> 12352
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12352
aguucugt                                                                 8


<210> 12353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12353
aaguucuguc caagcccggt                                                   20


<210> 12354
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12354
aaguucuguc caagcccgg                                                    19


<210> 12355
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12355
aaguucuguc caagcccg                                                     18


<210> 12356
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12356
aaguucuguc caagccc                                                      17


<210> 12357
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12357
aaguucuguc caagcc                                                       16


<210> 12358
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12358
aaguucuguc caagc                                                        15


<210> 12359
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12359
aaguucuguc caag                                                         14


<210> 12360
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12360
aaguucuguc caa                                                          13


<210> 12361
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12361
aaguucuguc ca                                                           12


<210> 12362
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12362
aaguucuguc c                                                            11


<210> 12363
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12363
aaguucugtc                                                              10


<210> 12364
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12364
aaguucugt                                                                9


<210> 12365
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12365
aaguuctg                                                                 8


<210> 12366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12366
taaguucugu ccaagcccgg                                                   20


<210> 12367
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12367
taaguucugu ccaagcccg                                                    19


<210> 12368
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12368
taaguucugu ccaagccc                                                     18


<210> 12369
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12369
taaguucugu ccaagcc                                                      17


<210> 12370
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12370
taaguucugu ccaagc                                                       16


<210> 12371
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12371
taaguucugu ccaa                                                         14


<210> 12372
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12372
taaguucugu cca                                                          13


<210> 12373
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12373
taaguucugu cc                                                           12


<210> 12374
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12374
taaguucugt c                                                            11


<210> 12375
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12375
taaguucugt                                                              10


<210> 12376
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12376
taaguuctg                                                                9


<210> 12377
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12377
taaguuct                                                                 8


<210> 12378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12378
gtaaguucug uccaagcccg                                                   20


<210> 12379
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12379
gtaaguucug uccaagccc                                                    19


<210> 12380
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12380
gtaaguucug uccaagc                                                      17


<210> 12381
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12381
gtaaguucug uccaag                                                       16


<210> 12382
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12382
gtaaguucug uccaa                                                        15


<210> 12383
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12383
gtaaguucug ucca                                                         14


<210> 12384
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12384
gtaaguucug ucc                                                          13


<210> 12385
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12385
gtaaguucug tc                                                           12


<210> 12386
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12386
gtaaguucug t                                                            11


<210> 12387
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12387
gtaaguuctg                                                              10


<210> 12388
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12388
gtaaguuct                                                                9


<210> 12389
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12389
gtaagutc                                                                 8


<210> 12390
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12390
gguaaguucu guccaagccc                                                   20


<210> 12391
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12391
gguaaguucu guccaagcc                                                    19


<210> 12392
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12392
gguaaguucu guccaag                                                      17


<210> 12393
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12393
gguaaguucu guccaa                                                       16


<210> 12394
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12394
gguaaguucu gucca                                                        15


<210> 12395
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12395
gguaaguucu gucc                                                         14


<210> 12396
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12396
gguaaguucu gtc                                                          13


<210> 12397
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12397
gguaaguucu gt                                                           12


<210> 12398
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12398
gguaaguuct g                                                            11


<210> 12399
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12399
gguaaguuct                                                              10


<210> 12400
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12400
gguaagutc                                                                9


<210> 12401
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12401
gguaagtt                                                                 8


<210> 12402
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12402
cgguaaguuc uguccaagcc                                                   20


<210> 12403
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12403
cgguaaguuc uguccaagc                                                    19


<210> 12404
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12404
cgguaaguuc uguccaag                                                     18


<210> 12405
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12405
cgguaaguuc uguccaa                                                      17


<210> 12406
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12406
cgguaaguuc ugucca                                                       16


<210> 12407
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12407
cgguaaguuc ugucc                                                        15


<210> 12408
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12408
cgguaaguuc ugtc                                                         14


<210> 12409
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12409
cgguaaguuc ugt                                                          13


<210> 12410
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12410
cgguaaguuc tg                                                           12


<210> 12411
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12411
cgguaaguuc t                                                            11


<210> 12412
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12412
cgguaagutc                                                              10


<210> 12413
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12413
cgguaagtt                                                                9


<210> 12414
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12414
cgguaagt                                                                 8


<210> 12415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12415
tcgguaaguu cuguccaagc                                                   20


<210> 12416
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12416
tcgguaaguu cuguccaag                                                    19


<210> 12417
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12417
tcgguaaguu cuguccaa                                                     18


<210> 12418
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12418
tcgguaaguu cugucca                                                      17


<210> 12419
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12419
tcgguaaguu cugucc                                                       16


<210> 12420
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12420
tcgguaaguu cugtc                                                        15


<210> 12421
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12421
tcgguaaguu cugt                                                         14


<210> 12422
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12422
tcgguaaguu ctg                                                          13


<210> 12423
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12423
tcgguaaguu ct                                                           12


<210> 12424
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12424
tcgguaagut c                                                            11


<210> 12425
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12425
tcgguaagtt                                                              10


<210> 12426
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12426
tcgguaagt                                                                9


<210> 12427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12427
gtcgguaagu ucuguccaag                                                   20


<210> 12428
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12428
gtcgguaagu ucuguccaa                                                    19


<210> 12429
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12429
gtcgguaagu ucugucca                                                     18


<210> 12430
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12430
gtcgguaagu ucugucc                                                      17


<210> 12431
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12431
gtcgguaagu ucugtc                                                       16


<210> 12432
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12432
gtcgguaagu ucugt                                                        15


<210> 12433
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12433
gtcgguaagu uctg                                                         14


<210> 12434
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12434
gtcgguaagu uct                                                          13


<210> 12435
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12435
gtcgguaagu tc                                                           12


<210> 12436
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12436
gtcgguaagt t                                                            11


<210> 12437
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12437
gtcgguaagt                                                              10


<210> 12438
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12438
agucgguaag uucuguccaa                                                   20


<210> 12439
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12439
agucgguaag uucugucca                                                    19


<210> 12440
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12440
agucgguaag uucugtc                                                      17


<210> 12441
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12441
agucgguaag uucugt                                                       16


<210> 12442
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12442
agucgguaag uuctg                                                        15


<210> 12443
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12443
agucgguaag uuct                                                         14


<210> 12444
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12444
agucgguaag utc                                                          13


<210> 12445
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12445
agucgguaag tt                                                           12


<210> 12446
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12446
agucgguaag t                                                            11


<210> 12447
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12447
cagucgguaa guucugucca                                                   20


<210> 12448
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12448
cagucgguaa guucugucc                                                    19


<210> 12449
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12449
cagucgguaa guucugtc                                                     18


<210> 12450
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12450
cagucgguaa guucugt                                                      17


<210> 12451
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12451
cagucgguaa guuctg                                                       16


<210> 12452
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12452
cagucgguaa guuct                                                        15


<210> 12453
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12453
cagucgguaa gutc                                                         14


<210> 12454
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12454
cagucgguaa gtt                                                          13


<210> 12455
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12455
cagucgguaa gt                                                           12


<210> 12456
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12456
ccagucggua aguucugucc                                                   20


<210> 12457
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12457
ccagucggua aguucugtc                                                    19


<210> 12458
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12458
ccagucggua aguucugt                                                     18


<210> 12459
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12459
ccagucggua aguuctg                                                      17


<210> 12460
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12460
ccagucggua aguuct                                                       16


<210> 12461
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12461
ccagucggua agutc                                                        15


<210> 12462
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12462
ccagucggua agtt                                                         14


<210> 12463
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12463
ccagucggua agt                                                          13


<210> 12464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12464
gccagucggu aaguucugtc                                                   20


<210> 12465
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12465
gccagucggu aaguucugt                                                    19


<210> 12466
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12466
gccagucggu aaguuctg                                                     18


<210> 12467
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12467
gccagucggu aaguuct                                                      17


<210> 12468
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12468
gccagucggu aagutc                                                       16


<210> 12469
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12469
gccagucggu aagtt                                                        15


<210> 12470
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12470
gccagucggu aagt                                                         14


<210> 12471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12471
tcaaggaaga uggcauuuct                                                   20


<210> 12472
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12472
tcaaggaaga uggcauuucu ag                                                22


<210> 12473
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12473
tcaaggaaga uggcat                                                       16


<210> 12474
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12474
gaagauggca uuuct                                                        15


<210> 12475
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12475
tcaaggaaga uggcauuuct a                                                 21


<210> 12476
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12476
tcaaggaaga uggcauutc                                                    19


<210> 12477
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12477
tcaaggaaga uggcautt                                                     18


<210> 12478
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12478
tcaaggaaga uggcatt                                                      17


<210> 12479
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12479
tcaaggaaga uggca                                                        15


<210> 12480
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12480
tcaaggaaga uggc                                                         14


<210> 12481
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12481
tcaaggaaga ugg                                                          13


<210> 12482
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12482
tcaaggaaga tg                                                           12


<210> 12483
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12483
tcaaggaaga t                                                            11


<210> 12484
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12484
tcaaggaaga                                                              10


<210> 12485
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12485
tcaaggaag                                                                9


<210> 12486
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12486
caaggaagau ggcauuucua g                                                 21


<210> 12487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12487
caaggaagau ggcauuucta                                                   20


<210> 12488
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12488
caaggaagau ggcauuuct                                                    19


<210> 12489
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12489
caaggaagau ggcauutc                                                     18


<210> 12490
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12490
caaggaagau ggcautt                                                      17


<210> 12491
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12491
caaggaagau ggcatt                                                       16


<210> 12492
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12492
caaggaagau ggcat                                                        15


<210> 12493
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12493
caaggaagau ggca                                                         14


<210> 12494
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12494
caaggaagau ggc                                                          13


<210> 12495
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12495
caaggaagau gg                                                           12


<210> 12496
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12496
caaggaagat g                                                            11


<210> 12497
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12497
caaggaagat                                                              10


<210> 12498
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12498
caaggaaga                                                                9


<210> 12499
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12499
caaggaag                                                                 8


<210> 12500
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12500
aaggaagaug gcauuucuag                                                   20


<210> 12501
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12501
aaggaagaug gcauuucta                                                    19


<210> 12502
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12502
aaggaagaug gcauuuct                                                     18


<210> 12503
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12503
aaggaagaug gcauutc                                                      17


<210> 12504
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12504
aaggaagaug gcautt                                                       16


<210> 12505
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12505
aaggaagaug gcatt                                                        15


<210> 12506
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12506
aaggaagaug gcat                                                         14


<210> 12507
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12507
aaggaagaug gca                                                          13


<210> 12508
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12508
aaggaagaug gc                                                           12


<210> 12509
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12509
aaggaagaug g                                                            11


<210> 12510
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12510
aaggaagatg                                                              10


<210> 12511
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12511
aaggaagat                                                                9


<210> 12512
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12512
aaggaaga                                                                 8


<210> 12513
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12513
aggaagaugg cauuucuag                                                    19


<210> 12514
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12514
aggaagaugg cauuucta                                                     18


<210> 12515
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12515
aggaagaugg cauuuct                                                      17


<210> 12516
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12516
aggaagaugg cauutc                                                       16


<210> 12517
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12517
aggaagaugg cautt                                                        15


<210> 12518
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12518
aggaagaugg catt                                                         14


<210> 12519
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12519
aggaagaugg cat                                                          13


<210> 12520
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12520
aggaagaugg ca                                                           12


<210> 12521
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12521
aggaagaugg                                                              10


<210> 12522
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12522
aggaagatg                                                                9


<210> 12523
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12523
aggaagat                                                                 8


<210> 12524
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12524
ggaagauggc auuucuag                                                     18


<210> 12525
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12525
ggaagauggc auuucta                                                      17


<210> 12526
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12526
ggaagauggc auuuct                                                       16


<210> 12527
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12527
ggaagauggc auutc                                                        15


<210> 12528
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12528
ggaagauggc autt                                                         14


<210> 12529
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12529
ggaagauggc att                                                          13


<210> 12530
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12530
ggaagauggc at                                                           12


<210> 12531
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12531
ggaagauggc a                                                            11


<210> 12532
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12532
ggaagauggc                                                              10


<210> 12533
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12533
ggaagatg                                                                 8


<210> 12534
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12534
gaagauggca uuucuag                                                      17


<210> 12535
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12535
gaagauggca uuucta                                                       16


<210> 12536
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12536
gaagauggca uutc                                                         14


<210> 12537
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12537
gaagauggca utt                                                          13


<210> 12538
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12538
gaagauggca tt                                                           12


<210> 12539
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12539
gaagauggca t                                                            11


<210> 12540
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12540
gaagauggca                                                              10


<210> 12541
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12541
gaagauggc                                                                9


<210> 12542
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12542
gaagaugg                                                                 8


<210> 12543
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12543
aagauggcau uucuag                                                       16


<210> 12544
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12544
aagauggcau uucta                                                        15


<210> 12545
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12545
aagauggcau uuct                                                         14


<210> 12546
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12546
aagauggcau utc                                                          13


<210> 12547
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12547
aagauggcau tt                                                           12


<210> 12548
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12548
aagauggcat t                                                            11


<210> 12549
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12549
aagauggcat                                                              10


<210> 12550
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12550
aagauggca                                                                9


<210> 12551
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12551
aagauggc                                                                 8


<210> 12552
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12552
agauggcauu ucuag                                                        15


<210> 12553
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12553
agauggcauu ucta                                                         14


<210> 12554
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12554
agauggcauu uct                                                          13


<210> 12555
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12555
agauggcauu tc                                                           12


<210> 12556
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12556
agauggcaut t                                                            11


<210> 12557
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12557
agauggcatt                                                              10


<210> 12558
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12558
agauggcat                                                                9


<210> 12559
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12559
agauggca                                                                 8


<210> 12560
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12560
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 12561
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12561
ctccaacauc aaggaagaug gcauuucta                                         29


<210> 12562
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12562
ctccaacauc aaggaagaug gcauuuct                                          28


<210> 12563
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12563
ctccaacauc aaggaagaug gcauutc                                           27


<210> 12564
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12564
ctccaacauc aaggaagaug gcautt                                            26


<210> 12565
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12565
ctccaacauc aaggaagaug gcatt                                             25


<210> 12566
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12566
ctccaacauc aaggaagaug gcat                                              24


<210> 12567
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12567
ctccaacauc aaggaagaug gca                                               23


<210> 12568
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12568
ctccaacauc aaggaagaug gc                                                22


<210> 12569
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12569
ctccaacauc aaggaagaug g                                                 21


<210> 12570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12570
ctccaacauc aaggaagatg                                                   20


<210> 12571
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12571
ctccaacauc aaggaagat                                                    19


<210> 12572
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12572
ctccaacauc aaggaaga                                                     18


<210> 12573
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12573
ctccaacauc aaggaag                                                      17


<210> 12574
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12574
tccaacauca aggaagaugg cauuucuag                                         29


<210> 12575
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12575
tccaacauca aggaagaugg cauuucta                                          28


<210> 12576
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12576
tccaacauca aggaagaugg cauuuct                                           27


<210> 12577
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12577
tccaacauca aggaagaugg cauutc                                            26


<210> 12578
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12578
tccaacauca aggaagaugg cautt                                             25


<210> 12579
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12579
tccaacauca aggaagaugg catt                                              24


<210> 12580
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12580
tccaacauca aggaagaugg cat                                               23


<210> 12581
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12581
tccaacauca aggaagaugg ca                                                22


<210> 12582
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12582
tccaacauca aggaagaugg c                                                 21


<210> 12583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12583
tccaacauca aggaagaugg                                                   20


<210> 12584
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12584
tccaacauca aggaagatg                                                    19


<210> 12585
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12585
tccaacauca aggaagat                                                     18


<210> 12586
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12586
tccaacauca aggaaga                                                      17


<210> 12587
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12587
tccaacauca aggaag                                                       16


<210> 12588
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12588
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 12589
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12589
ccaacaucaa ggaagauggc auuucta                                           27


<210> 12590
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12590
ccaacaucaa ggaagauggc auuuct                                            26


<210> 12591
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12591
ccaacaucaa ggaagauggc auutc                                             25


<210> 12592
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12592
ccaacaucaa ggaagauggc autt                                              24


<210> 12593
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12593
ccaacaucaa ggaagauggc att                                               23


<210> 12594
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12594
ccaacaucaa ggaagauggc at                                                22


<210> 12595
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12595
ccaacaucaa ggaagauggc a                                                 21


<210> 12596
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12596
ccaacaucaa ggaagauggc                                                   20


<210> 12597
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12597
ccaacaucaa ggaagaugg                                                    19


<210> 12598
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12598
ccaacaucaa ggaagatg                                                     18


<210> 12599
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12599
ccaacaucaa ggaagat                                                      17


<210> 12600
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12600
ccaacaucaa ggaaga                                                       16


<210> 12601
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12601
ccaacaucaa ggaag                                                        15


<210> 12602
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12602
caacaucaag gaagauggca uuucuag                                           27


<210> 12603
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12603
caacaucaag gaagauggca uuucta                                            26


<210> 12604
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12604
caacaucaag gaagauggca uuuct                                             25


<210> 12605
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12605
caacaucaag gaagauggca uutc                                              24


<210> 12606
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12606
caacaucaag gaagauggca utt                                               23


<210> 12607
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12607
caacaucaag gaagauggca tt                                                22


<210> 12608
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12608
caacaucaag gaagauggca t                                                 21


<210> 12609
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12609
caacaucaag gaagauggca                                                   20


<210> 12610
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12610
caacaucaag gaagauggc                                                    19


<210> 12611
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12611
caacaucaag gaagaugg                                                     18


<210> 12612
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12612
caacaucaag gaagatg                                                      17


<210> 12613
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12613
caacaucaag gaagat                                                       16


<210> 12614
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12614
caacaucaag gaaga                                                        15


<210> 12615
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12615
caacaucaag gaag                                                         14


<210> 12616
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12616
aacaucaagg aagauggcau uucuag                                            26


<210> 12617
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12617
aacaucaagg aagauggcau uucta                                             25


<210> 12618
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12618
aacaucaagg aagauggcau uuct                                              24


<210> 12619
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12619
aacaucaagg aagauggcau utc                                               23


<210> 12620
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12620
aacaucaagg aagauggcau tt                                                22


<210> 12621
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12621
aacaucaagg aagauggcat t                                                 21


<210> 12622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12622
aacaucaagg aagauggcat                                                   20


<210> 12623
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12623
aacaucaagg aagauggca                                                    19


<210> 12624
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12624
aacaucaagg aagauggc                                                     18


<210> 12625
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12625
aacaucaagg aagaugg                                                      17


<210> 12626
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12626
aacaucaagg aagatg                                                       16


<210> 12627
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12627
aacaucaagg aagat                                                        15


<210> 12628
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12628
aacaucaagg aaga                                                         14


<210> 12629
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12629
aacaucaagg aag                                                          13


<210> 12630
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12630
acaucaagga agauggcauu ucuag                                             25


<210> 12631
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12631
acaucaagga agauggcauu ucta                                              24


<210> 12632
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12632
acaucaagga agauggcauu uct                                               23


<210> 12633
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12633
acaucaagga agauggcauu tc                                                22


<210> 12634
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12634
acaucaagga agauggcaut t                                                 21


<210> 12635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12635
acaucaagga agauggcatt                                                   20


<210> 12636
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12636
acaucaagga agauggcat                                                    19


<210> 12637
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12637
acaucaagga agauggca                                                     18


<210> 12638
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12638
acaucaagga agauggc                                                      17


<210> 12639
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12639
acaucaagga agaugg                                                       16


<210> 12640
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12640
acaucaagga agatg                                                        15


<210> 12641
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12641
acaucaagga agat                                                         14


<210> 12642
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12642
acaucaagga aga                                                          13


<210> 12643
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12643
acaucaagga ag                                                           12


<210> 12644
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12644
caucaaggaa gauggcauuu cuag                                              24


<210> 12645
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12645
caucaaggaa gauggcauuu cta                                               23


<210> 12646
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12646
caucaaggaa gauggcauuu ct                                                22


<210> 12647
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12647
caucaaggaa gauggcauut c                                                 21


<210> 12648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12648
caucaaggaa gauggcautt                                                   20


<210> 12649
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12649
caucaaggaa gauggcatt                                                    19


<210> 12650
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12650
caucaaggaa gauggcat                                                     18


<210> 12651
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12651
caucaaggaa gauggca                                                      17


<210> 12652
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12652
caucaaggaa gauggc                                                       16


<210> 12653
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12653
caucaaggaa gaugg                                                        15


<210> 12654
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12654
caucaaggaa gatg                                                         14


<210> 12655
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12655
caucaaggaa gat                                                          13


<210> 12656
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12656
caucaaggaa ga                                                           12


<210> 12657
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12657
caucaaggaa g                                                            11


<210> 12658
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12658
atcaaggaag auggcauuuc uag                                               23


<210> 12659
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12659
atcaaggaag auggcauuuc ta                                                22


<210> 12660
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12660
atcaaggaag auggcauuuc t                                                 21


<210> 12661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12661
atcaaggaag auggcauutc                                                   20


<210> 12662
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12662
atcaaggaag auggcautt                                                    19


<210> 12663
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12663
atcaaggaag auggcatt                                                     18


<210> 12664
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12664
atcaaggaag auggcat                                                      17


<210> 12665
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12665
atcaaggaag auggca                                                       16


<210> 12666
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12666
atcaaggaag auggc                                                        15


<210> 12667
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12667
atcaaggaag augg                                                         14


<210> 12668
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12668
atcaaggaag atg                                                          13


<210> 12669
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12669
atcaaggaag at                                                           12


<210> 12670
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12670
atcaaggaag a                                                            11


<210> 12671
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12671
atcaaggaag                                                              10


<210> 12672
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12672
ccagagcagg uaccuccaac atc                                               23


<210> 12673
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12673
ccagagcagg uaccucca                                                     18


<210> 12674
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12674
ccucugugau uuuauaacuu gat                                               23


<210> 12675
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12675
tcacccacca ucaccct                                                      17


<210> 12676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12676
tgauauccuc aaggucaccc                                                   20


<210> 12677
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12677
ctgcuugaug aucaucucgu tg                                                22


<210> 12678
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12678
ctgcuugaug aucauctc                                                     18


<210> 12679
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12679
gtuuccuuag uaaccacag                                                    19


<210> 12680
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 12680
gtuuccuuag uaaccac                                                      17


<210> 12681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12681
tcaaggaaga uggcauuucu                                                   20


<210> 12682
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12682
tcaaggaaga uggcauuucu ag                                                22


<210> 12683
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12683
gguaaguucu guccaagc                                                     18


<210> 12684
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12684
guaaguucug uccaagcc                                                     18


<210> 12685
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12685
agucgguaag uucugucc                                                     18


<210> 12686
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12686
cuguccaagc ccgguuga                                                     18


<210> 12687
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12687
taaguucugu ccaag                                                        15


<210> 12688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12688
tucuguccaa gcccgguuga                                                   20


<210> 12689
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12689
tucuguccaa gcccgguug                                                    19


<210> 12690
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12690
tucuguccaa gcccgguu                                                     18


<210> 12691
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12691
tucuguccaa gcccggu                                                      17


<210> 12692
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12692
tucuguccaa gcccgg                                                       16


<210> 12693
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12693
tucuguccaa gcccg                                                        15


<210> 12694
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12694
tucuguccaa gccc                                                         14


<210> 12695
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12695
tucuguccaa gcc                                                          13


<210> 12696
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12696
tucuguccaa gc                                                           12


<210> 12697
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12697
tucuguccaa g                                                            11


<210> 12698
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12698
tucuguccaa                                                              10


<210> 12699
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12699
tucugucca                                                                9


<210> 12700
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12700
tucugucc                                                                 8


<210> 12701
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12701
tcuguccaag cccgguuga                                                    19


<210> 12702
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12702
tcuguccaag cccgguug                                                     18


<210> 12703
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12703
tcuguccaag cccgguu                                                      17


<210> 12704
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12704
tcuguccaag cccggu                                                       16


<210> 12705
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12705
tcuguccaag cccgg                                                        15


<210> 12706
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12706
tcuguccaag cccg                                                         14


<210> 12707
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12707
tcuguccaag ccc                                                          13


<210> 12708
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12708
tcuguccaag cc                                                           12


<210> 12709
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12709
tcuguccaag c                                                            11


<210> 12710
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12710
tcuguccaag                                                              10


<210> 12711
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12711
tcuguccaa                                                                9


<210> 12712
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12712
tcugucca                                                                 8


<210> 12713
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12713
cuguccaagc ccgguug                                                      17


<210> 12714
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12714
cuguccaagc ccgguu                                                       16


<210> 12715
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12715
cuguccaagc ccggu                                                        15


<210> 12716
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12716
cuguccaagc ccgg                                                         14


<210> 12717
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12717
cuguccaagc ccg                                                          13


<210> 12718
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12718
cuguccaagc cc                                                           12


<210> 12719
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12719
cuguccaagc c                                                            11


<210> 12720
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12720
cuguccaagc                                                              10


<210> 12721
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 12721
cuguccaag                                                                9


<210> 12722
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 12722
cuguccaa                                                                 8


<210> 12723
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12723
guucugucca agcccgguug                                                   20


<210> 12724
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12724
guucugucca agcccgguu                                                    19


<210> 12725
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12725
guucugucca agcccggu                                                     18


<210> 12726
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12726
guucugucca agcccgg                                                      17


<210> 12727
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12727
guucugucca agcccg                                                       16


<210> 12728
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12728
guucugucca agccc                                                        15


<210> 12729
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12729
guucugucca agcc                                                         14


<210> 12730
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12730
guucugucca agc                                                          13


<210> 12731
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12731
guucugucca ag                                                           12


<210> 12732
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12732
guucugucca a                                                            11


<210> 12733
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12733
guucugucca                                                              10


<210> 12734
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12734
guucugucc                                                                9


<210> 12735
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12735
guucuguc                                                                 8


<210> 12736
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12736
aguucugucc aagcccgguu                                                   20


<210> 12737
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12737
aguucugucc aagcccggu                                                    19


<210> 12738
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12738
aguucugucc aagcccgg                                                     18


<210> 12739
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12739
aguucugucc aagcccg                                                      17


<210> 12740
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12740
aguucugucc aagccc                                                       16


<210> 12741
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12741
aguucugucc aagcc                                                        15


<210> 12742
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12742
aguucugucc aagc                                                         14


<210> 12743
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12743
aguucugucc aag                                                          13


<210> 12744
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12744
aguucugucc aa                                                           12


<210> 12745
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12745
aguucugucc a                                                            11


<210> 12746
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12746
aguucugucc                                                              10


<210> 12747
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12747
aguucuguc                                                                9


<210> 12748
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 12748
aguucugu                                                                 8


<210> 12749
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12749
aaguucuguc caagcccggu                                                   20


<210> 12750
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12750
aaguucuguc caagcccgg                                                    19


<210> 12751
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12751
aaguucuguc caagcccg                                                     18


<210> 12752
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12752
aaguucuguc caagccc                                                      17


<210> 12753
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12753
aaguucuguc caagcc                                                       16


<210> 12754
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12754
aaguucuguc caagc                                                        15


<210> 12755
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12755
aaguucuguc caag                                                         14


<210> 12756
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12756
aaguucuguc caa                                                          13


<210> 12757
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12757
aaguucuguc ca                                                           12


<210> 12758
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12758
aaguucuguc c                                                            11


<210> 12759
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12759
aaguucuguc                                                              10


<210> 12760
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 12760
aaguucugu                                                                9


<210> 12761
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 12761
aaguucug                                                                 8


<210> 12762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12762
taaguucugu ccaagcccgg                                                   20


<210> 12763
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12763
taaguucugu ccaagcccg                                                    19


<210> 12764
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12764
taaguucugu ccaagccc                                                     18


<210> 12765
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12765
taaguucugu ccaagcc                                                      17


<210> 12766
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12766
taaguucugu ccaagc                                                       16


<210> 12767
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12767
taaguucugu ccaa                                                         14


<210> 12768
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12768
taaguucugu cca                                                          13


<210> 12769
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12769
taaguucugu cc                                                           12


<210> 12770
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12770
taaguucugu c                                                            11


<210> 12771
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12771
taaguucugu                                                              10


<210> 12772
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12772
taaguucug                                                                9


<210> 12773
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12773
taaguucu                                                                 8


<210> 12774
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12774
guaaguucug uccaagcccg                                                   20


<210> 12775
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12775
guaaguucug uccaagccc                                                    19


<210> 12776
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12776
guaaguucug uccaagc                                                      17


<210> 12777
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12777
guaaguucug uccaag                                                       16


<210> 12778
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12778
guaaguucug uccaa                                                        15


<210> 12779
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12779
guaaguucug ucca                                                         14


<210> 12780
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12780
guaaguucug ucc                                                          13


<210> 12781
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12781
guaaguucug uc                                                           12


<210> 12782
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12782
guaaguucug u                                                            11


<210> 12783
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12783
guaaguucug                                                              10


<210> 12784
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12784
guaaguucu                                                                9


<210> 12785
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12785
guaaguuc                                                                 8


<210> 12786
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 12786
gguaaguucu guccaagccc                                                   20


<210> 12787
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12787
gguaaguucu guccaagcc                                                    19


<210> 12788
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12788
gguaaguucu guccaag                                                      17


<210> 12789
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12789
gguaaguucu guccaa                                                       16


<210> 12790
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12790
gguaaguucu gucca                                                        15


<210> 12791
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12791
gguaaguucu gucc                                                         14


<210> 12792
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12792
gguaaguucu guc                                                          13


<210> 12793
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12793
gguaaguucu gu                                                           12


<210> 12794
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12794
gguaaguucu g                                                            11


<210> 12795
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12795
gguaaguucu                                                              10


<210> 12796
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12796
gguaaguuc                                                                9


<210> 12797
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 12797
gguaaguu                                                                 8


<210> 12798
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 12798
cgguaaguuc uguccaagcc                                                   20


<210> 12799
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12799
cgguaaguuc uguccaagc                                                    19


<210> 12800
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12800
cgguaaguuc uguccaag                                                     18


<210> 12801
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12801
cgguaaguuc uguccaa                                                      17


<210> 12802
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12802
cgguaaguuc ugucca                                                       16


<210> 12803
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12803
cgguaaguuc ugucc                                                        15


<210> 12804
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12804
cgguaaguuc uguc                                                         14


<210> 12805
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12805
cgguaaguuc ugu                                                          13


<210> 12806
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12806
cgguaaguuc ug                                                           12


<210> 12807
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12807
cgguaaguuc u                                                            11


<210> 12808
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12808
cgguaaguuc                                                              10


<210> 12809
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 12809
cgguaaguu                                                                9


<210> 12810
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 12810
cgguaagu                                                                 8


<210> 12811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 12811
tcgguaaguu cuguccaagc                                                   20


<210> 12812
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12812
tcgguaaguu cuguccaag                                                    19


<210> 12813
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12813
tcgguaaguu cuguccaa                                                     18


<210> 12814
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12814
tcgguaaguu cugucca                                                      17


<210> 12815
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12815
tcgguaaguu cugucc                                                       16


<210> 12816
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12816
tcgguaaguu cuguc                                                        15


<210> 12817
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12817
tcgguaaguu cugu                                                         14


<210> 12818
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12818
tcgguaaguu cug                                                          13


<210> 12819
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12819
tcgguaaguu cu                                                           12


<210> 12820
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12820
tcgguaaguu c                                                            11


<210> 12821
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 12821
tcgguaaguu                                                              10


<210> 12822
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 12822
tcgguaagu                                                                9


<210> 12823
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12823
gucgguaagu ucuguccaag                                                   20


<210> 12824
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12824
gucgguaagu ucuguccaa                                                    19


<210> 12825
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12825
gucgguaagu ucugucca                                                     18


<210> 12826
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12826
gucgguaagu ucugucc                                                      17


<210> 12827
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12827
gucgguaagu ucuguc                                                       16


<210> 12828
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12828
gucgguaagu ucugu                                                        15


<210> 12829
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12829
gucgguaagu ucug                                                         14


<210> 12830
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12830
gucgguaagu ucu                                                          13


<210> 12831
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12831
gucgguaagu uc                                                           12


<210> 12832
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 12832
gucgguaagu u                                                            11


<210> 12833
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 12833
gucgguaagu                                                              10


<210> 12834
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12834
agucgguaag uucuguccaa                                                   20


<210> 12835
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12835
agucgguaag uucugucca                                                    19


<210> 12836
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12836
agucgguaag uucuguc                                                      17


<210> 12837
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12837
agucgguaag uucugu                                                       16


<210> 12838
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12838
agucgguaag uucug                                                        15


<210> 12839
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12839
agucgguaag uucu                                                         14


<210> 12840
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12840
agucgguaag uuc                                                          13


<210> 12841
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 12841
agucgguaag uu                                                           12


<210> 12842
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 12842
agucgguaag u                                                            11


<210> 12843
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12843
cagucgguaa guucugucca                                                   20


<210> 12844
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12844
cagucgguaa guucugucc                                                    19


<210> 12845
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12845
cagucgguaa guucuguc                                                     18


<210> 12846
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12846
cagucgguaa guucugu                                                      17


<210> 12847
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12847
cagucgguaa guucug                                                       16


<210> 12848
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12848
cagucgguaa guucu                                                        15


<210> 12849
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12849
cagucgguaa guuc                                                         14


<210> 12850
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 12850
cagucgguaa guu                                                          13


<210> 12851
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 12851
cagucgguaa gu                                                           12


<210> 12852
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 12852
ccagucggua aguucugucc                                                   20


<210> 12853
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12853
ccagucggua aguucuguc                                                    19


<210> 12854
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12854
ccagucggua aguucugu                                                     18


<210> 12855
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12855
ccagucggua aguucug                                                      17


<210> 12856
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12856
ccagucggua aguucu                                                       16


<210> 12857
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12857
ccagucggua aguuc                                                        15


<210> 12858
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 12858
ccagucggua aguu                                                         14


<210> 12859
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 12859
ccagucggua agu                                                          13


<210> 12860
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 12860
gccagucggu aaguucuguc                                                   20


<210> 12861
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12861
gccagucggu aaguucugu                                                    19


<210> 12862
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12862
gccagucggu aaguucug                                                     18


<210> 12863
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12863
gccagucggu aaguucu                                                      17


<210> 12864
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12864
gccagucggu aaguuc                                                       16


<210> 12865
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12865
gccagucggu aaguu                                                        15


<210> 12866
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12866
gccagucggu aagu                                                         14


<210> 12867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12867
tcaaggaaga uggcauuucu                                                   20


<210> 12868
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12868
tcaaggaaga uggcauuucu ag                                                22


<210> 12869
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12869
tcaaggaaga uggcau                                                       16


<210> 12870
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12870
gaagauggca uuucu                                                        15


<210> 12871
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12871
tcaaggaaga uggcauuucu a                                                 21


<210> 12872
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 12872
tcaaggaaga uggcauuuc                                                    19


<210> 12873
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12873
tcaaggaaga uggcauuu                                                     18


<210> 12874
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12874
tcaaggaaga uggcauu                                                      17


<210> 12875
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12875
tcaaggaaga uggca                                                        15


<210> 12876
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12876
tcaaggaaga uggc                                                         14


<210> 12877
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 12877
tcaaggaaga ugg                                                          13


<210> 12878
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 12878
tcaaggaaga ug                                                           12


<210> 12879
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 12879
tcaaggaaga u                                                            11


<210> 12880
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 12880
tcaaggaaga                                                              10


<210> 12881
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 12881
tcaaggaag                                                                9


<210> 12882
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12882
caaggaagau ggcauuucua g                                                 21


<210> 12883
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12883
caaggaagau ggcauuucua                                                   20


<210> 12884
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12884
caaggaagau ggcauuucu                                                    19


<210> 12885
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 12885
caaggaagau ggcauuuc                                                     18


<210> 12886
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12886
caaggaagau ggcauuu                                                      17


<210> 12887
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12887
caaggaagau ggcauu                                                       16


<210> 12888
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12888
caaggaagau ggcau                                                        15


<210> 12889
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12889
caaggaagau ggca                                                         14


<210> 12890
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12890
caaggaagau ggc                                                          13


<210> 12891
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 12891
caaggaagau gg                                                           12


<210> 12892
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 12892
caaggaagau g                                                            11


<210> 12893
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 12893
caaggaagau                                                              10


<210> 12894
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 12894
caaggaaga                                                                9


<210> 12895
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 12895
caaggaag                                                                 8


<210> 12896
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12896
aaggaagaug gcauuucuag                                                   20


<210> 12897
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12897
aaggaagaug gcauuucua                                                    19


<210> 12898
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12898
aaggaagaug gcauuucu                                                     18


<210> 12899
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 12899
aaggaagaug gcauuuc                                                      17


<210> 12900
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12900
aaggaagaug gcauuu                                                       16


<210> 12901
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12901
aaggaagaug gcauu                                                        15


<210> 12902
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12902
aaggaagaug gcau                                                         14


<210> 12903
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12903
aaggaagaug gca                                                          13


<210> 12904
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12904
aaggaagaug gc                                                           12


<210> 12905
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 12905
aaggaagaug g                                                            11


<210> 12906
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 12906
aaggaagaug                                                              10


<210> 12907
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 12907
aaggaagau                                                                9


<210> 12908
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 12908
aaggaaga                                                                 8


<210> 12909
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12909
aggaagaugg cauuucuag                                                    19


<210> 12910
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12910
aggaagaugg cauuucua                                                     18


<210> 12911
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12911
aggaagaugg cauuucu                                                      17


<210> 12912
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 12912
aggaagaugg cauuuc                                                       16


<210> 12913
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12913
aggaagaugg cauuu                                                        15


<210> 12914
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12914
aggaagaugg cauu                                                         14


<210> 12915
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12915
aggaagaugg cau                                                          13


<210> 12916
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 12916
aggaagaugg ca                                                           12


<210> 12917
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 12917
aggaagaugg                                                              10


<210> 12918
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 12918
aggaagaug                                                                9


<210> 12919
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 12919
aggaagau                                                                 8


<210> 12920
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12920
ggaagauggc auuucuag                                                     18


<210> 12921
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12921
ggaagauggc auuucua                                                      17


<210> 12922
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12922
ggaagauggc auuucu                                                       16


<210> 12923
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 12923
ggaagauggc auuuc                                                        15


<210> 12924
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12924
ggaagauggc auuu                                                         14


<210> 12925
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12925
ggaagauggc auu                                                          13


<210> 12926
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12926
ggaagauggc au                                                           12


<210> 12927
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12927
ggaagauggc a                                                            11


<210> 12928
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12928
ggaagauggc                                                              10


<210> 12929
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 12929
ggaagaug                                                                 8


<210> 12930
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12930
gaagauggca uuucuag                                                      17


<210> 12931
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12931
gaagauggca uuucua                                                       16


<210> 12932
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 12932
gaagauggca uuuc                                                         14


<210> 12933
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12933
gaagauggca uuu                                                          13


<210> 12934
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12934
gaagauggca uu                                                           12


<210> 12935
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12935
gaagauggca u                                                            11


<210> 12936
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12936
gaagauggca                                                              10


<210> 12937
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12937
gaagauggc                                                                9


<210> 12938
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 12938
gaagaugg                                                                 8


<210> 12939
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12939
aagauggcau uucuag                                                       16


<210> 12940
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12940
aagauggcau uucua                                                        15


<210> 12941
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12941
aagauggcau uucu                                                         14


<210> 12942
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 12942
aagauggcau uuc                                                          13


<210> 12943
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12943
aagauggcau uu                                                           12


<210> 12944
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12944
aagauggcau u                                                            11


<210> 12945
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12945
aagauggcau                                                              10


<210> 12946
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12946
aagauggca                                                                9


<210> 12947
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12947
aagauggc                                                                 8


<210> 12948
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12948
agauggcauu ucuag                                                        15


<210> 12949
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12949
agauggcauu ucua                                                         14


<210> 12950
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12950
agauggcauu ucu                                                          13


<210> 12951
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 12951
agauggcauu uc                                                           12


<210> 12952
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12952
agauggcauu u                                                            11


<210> 12953
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12953
agauggcauu                                                              10


<210> 12954
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12954
agauggcau                                                                9


<210> 12955
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 12955
agauggca                                                                 8


<210> 12956
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 12956
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 12957
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 12957
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 12958
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 12958
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 12959
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 12959
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 12960
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 12960
cuccaacauc aaggaagaug gcauuu                                            26


<210> 12961
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 12961
cuccaacauc aaggaagaug gcauu                                             25


<210> 12962
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 12962
cuccaacauc aaggaagaug gcau                                              24


<210> 12963
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 12963
cuccaacauc aaggaagaug gca                                               23


<210> 12964
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 12964
cuccaacauc aaggaagaug gc                                                22


<210> 12965
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12965
cuccaacauc aaggaagaug g                                                 21


<210> 12966
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12966
cuccaacauc aaggaagaug                                                   20


<210> 12967
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12967
cuccaacauc aaggaagau                                                    19


<210> 12968
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12968
cuccaacauc aaggaaga                                                     18


<210> 12969
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 12969
cuccaacauc aaggaag                                                      17


<210> 12970
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 12970
tccaacauca aggaagaugg cauuucuag                                         29


<210> 12971
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 12971
tccaacauca aggaagaugg cauuucua                                          28


<210> 12972
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 12972
tccaacauca aggaagaugg cauuucu                                           27


<210> 12973
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 12973
tccaacauca aggaagaugg cauuuc                                            26


<210> 12974
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 12974
tccaacauca aggaagaugg cauuu                                             25


<210> 12975
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 12975
tccaacauca aggaagaugg cauu                                              24


<210> 12976
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 12976
tccaacauca aggaagaugg cau                                               23


<210> 12977
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 12977
tccaacauca aggaagaugg ca                                                22


<210> 12978
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 12978
tccaacauca aggaagaugg c                                                 21


<210> 12979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12979
tccaacauca aggaagaugg                                                   20


<210> 12980
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12980
tccaacauca aggaagaug                                                    19


<210> 12981
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12981
tccaacauca aggaagau                                                     18


<210> 12982
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12982
tccaacauca aggaaga                                                      17


<210> 12983
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 12983
tccaacauca aggaag                                                       16


<210> 12984
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 12984
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 12985
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 12985
ccaacaucaa ggaagauggc auuucua                                           27


<210> 12986
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 12986
ccaacaucaa ggaagauggc auuucu                                            26


<210> 12987
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 12987
ccaacaucaa ggaagauggc auuuc                                             25


<210> 12988
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 12988
ccaacaucaa ggaagauggc auuu                                              24


<210> 12989
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 12989
ccaacaucaa ggaagauggc auu                                               23


<210> 12990
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 12990
ccaacaucaa ggaagauggc au                                                22


<210> 12991
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 12991
ccaacaucaa ggaagauggc a                                                 21


<210> 12992
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 12992
ccaacaucaa ggaagauggc                                                   20


<210> 12993
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12993
ccaacaucaa ggaagaugg                                                    19


<210> 12994
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12994
ccaacaucaa ggaagaug                                                     18


<210> 12995
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12995
ccaacaucaa ggaagau                                                      17


<210> 12996
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12996
ccaacaucaa ggaaga                                                       16


<210> 12997
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 12997
ccaacaucaa ggaag                                                        15


<210> 12998
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 12998
caacaucaag gaagauggca uuucuag                                           27


<210> 12999
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 12999
caacaucaag gaagauggca uuucua                                            26


<210> 13000
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 13000
caacaucaag gaagauggca uuucu                                             25


<210> 13001
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 13001
caacaucaag gaagauggca uuuc                                              24


<210> 13002
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13002
caacaucaag gaagauggca uuu                                               23


<210> 13003
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13003
caacaucaag gaagauggca uu                                                22


<210> 13004
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13004
caacaucaag gaagauggca u                                                 21


<210> 13005
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13005
caacaucaag gaagauggca                                                   20


<210> 13006
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13006
caacaucaag gaagauggc                                                    19


<210> 13007
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13007
caacaucaag gaagaugg                                                     18


<210> 13008
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13008
caacaucaag gaagaug                                                      17


<210> 13009
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13009
caacaucaag gaagau                                                       16


<210> 13010
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13010
caacaucaag gaaga                                                        15


<210> 13011
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13011
caacaucaag gaag                                                         14


<210> 13012
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 13012
aacaucaagg aagauggcau uucuag                                            26


<210> 13013
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 13013
aacaucaagg aagauggcau uucua                                             25


<210> 13014
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 13014
aacaucaagg aagauggcau uucu                                              24


<210> 13015
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 13015
aacaucaagg aagauggcau uuc                                               23


<210> 13016
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13016
aacaucaagg aagauggcau uu                                                22


<210> 13017
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13017
aacaucaagg aagauggcau u                                                 21


<210> 13018
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13018
aacaucaagg aagauggcau                                                   20


<210> 13019
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13019
aacaucaagg aagauggca                                                    19


<210> 13020
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13020
aacaucaagg aagauggc                                                     18


<210> 13021
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13021
aacaucaagg aagaugg                                                      17


<210> 13022
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13022
aacaucaagg aagaug                                                       16


<210> 13023
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13023
aacaucaagg aagau                                                        15


<210> 13024
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13024
aacaucaagg aaga                                                         14


<210> 13025
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13025
aacaucaagg aag                                                          13


<210> 13026
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13026
acaucaagga agauggcauu ucuag                                             25


<210> 13027
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13027
acaucaagga agauggcauu ucua                                              24


<210> 13028
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13028
acaucaagga agauggcauu ucu                                               23


<210> 13029
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13029
acaucaagga agauggcauu uc                                                22


<210> 13030
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13030
acaucaagga agauggcauu u                                                 21


<210> 13031
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13031
acaucaagga agauggcauu                                                   20


<210> 13032
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13032
acaucaagga agauggcau                                                    19


<210> 13033
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13033
acaucaagga agauggca                                                     18


<210> 13034
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13034
acaucaagga agauggc                                                      17


<210> 13035
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13035
acaucaagga agaugg                                                       16


<210> 13036
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13036
acaucaagga agaug                                                        15


<210> 13037
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13037
acaucaagga agau                                                         14


<210> 13038
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13038
acaucaagga aga                                                          13


<210> 13039
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13039
acaucaagga ag                                                           12


<210> 13040
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13040
caucaaggaa gauggcauuu cuag                                              24


<210> 13041
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13041
caucaaggaa gauggcauuu cua                                               23


<210> 13042
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13042
caucaaggaa gauggcauuu cu                                                22


<210> 13043
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13043
caucaaggaa gauggcauuu c                                                 21


<210> 13044
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13044
caucaaggaa gauggcauuu                                                   20


<210> 13045
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13045
caucaaggaa gauggcauu                                                    19


<210> 13046
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13046
caucaaggaa gauggcau                                                     18


<210> 13047
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13047
caucaaggaa gauggca                                                      17


<210> 13048
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13048
caucaaggaa gauggc                                                       16


<210> 13049
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13049
caucaaggaa gaugg                                                        15


<210> 13050
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13050
caucaaggaa gaug                                                         14


<210> 13051
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13051
caucaaggaa gau                                                          13


<210> 13052
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13052
caucaaggaa ga                                                           12


<210> 13053
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13053
caucaaggaa g                                                            11


<210> 13054
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13054
aucaaggaag auggcauuuc uag                                               23


<210> 13055
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13055
aucaaggaag auggcauuuc ua                                                22


<210> 13056
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13056
aucaaggaag auggcauuuc u                                                 21


<210> 13057
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13057
aucaaggaag auggcauuuc                                                   20


<210> 13058
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13058
aucaaggaag auggcauuu                                                    19


<210> 13059
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13059
aucaaggaag auggcauu                                                     18


<210> 13060
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13060
aucaaggaag auggcau                                                      17


<210> 13061
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13061
aucaaggaag auggca                                                       16


<210> 13062
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13062
aucaaggaag auggc                                                        15


<210> 13063
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13063
aucaaggaag augg                                                         14


<210> 13064
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13064
aucaaggaag aug                                                          13


<210> 13065
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13065
aucaaggaag au                                                           12


<210> 13066
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13066
aucaaggaag a                                                            11


<210> 13067
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13067
aucaaggaag                                                              10


<210> 13068
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 13068
ccagagcagg uaccuccaac auc                                               23


<210> 13069
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13069
ccagagcagg uaccucca                                                     18


<210> 13070
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13070
ccucugugau uuuauaacuu gau                                               23


<210> 13071
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13071
tcacccacca ucacccu                                                      17


<210> 13072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13072
tgauauccuc aaggucaccc                                                   20


<210> 13073
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13073
cugcuugaug aucaucucgu ug                                                22


<210> 13074
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13074
cugcuugaug aucaucuc                                                     18


<210> 13075
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13075
guuuccuuag uaaccacag                                                    19


<210> 13076
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13076
guuuccuuag uaaccac                                                      17


<210> 13077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13077
tcaaggaaga uggcauuucu                                                   20


<210> 13078
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13078
tcaaggaaga uggcauuucu ag                                                22


<210> 13079
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13079
gguaaguucu guccaagc                                                     18


<210> 13080
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13080
guaaguucug uccaagcc                                                     18


<210> 13081
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13081
agucgguaag uucugucc                                                     18


<210> 13082
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13082
cuguccaagc ccgguuga                                                     18


<210> 13083
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13083
taaguucugu ccaag                                                        15


<210> 13084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13084
tucuguccaa gcccgguuga                                                   20


<210> 13085
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13085
tucuguccaa gcccgguug                                                    19


<210> 13086
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13086
tucuguccaa gcccgguu                                                     18


<210> 13087
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13087
tucuguccaa gcccggu                                                      17


<210> 13088
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13088
tucuguccaa gcccgg                                                       16


<210> 13089
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13089
tucuguccaa gcccg                                                        15


<210> 13090
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13090
tucuguccaa gccc                                                         14


<210> 13091
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13091
tucuguccaa gcc                                                          13


<210> 13092
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13092
tucuguccaa gc                                                           12


<210> 13093
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13093
tucuguccaa g                                                            11


<210> 13094
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13094
tucuguccaa                                                              10


<210> 13095
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13095
tucugucca                                                                9


<210> 13096
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13096
tucugucc                                                                 8


<210> 13097
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13097
tcuguccaag cccgguuga                                                    19


<210> 13098
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13098
tcuguccaag cccgguug                                                     18


<210> 13099
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13099
tcuguccaag cccgguu                                                      17


<210> 13100
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13100
tcuguccaag cccggu                                                       16


<210> 13101
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13101
tcuguccaag cccgg                                                        15


<210> 13102
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13102
tcuguccaag cccg                                                         14


<210> 13103
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13103
tcuguccaag ccc                                                          13


<210> 13104
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13104
tcuguccaag cc                                                           12


<210> 13105
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13105
tcuguccaag c                                                            11


<210> 13106
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13106
tcuguccaag                                                              10


<210> 13107
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13107
tcuguccaa                                                                9


<210> 13108
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13108
tcugucca                                                                 8


<210> 13109
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13109
cuguccaagc ccgguug                                                      17


<210> 13110
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13110
cuguccaagc ccgguu                                                       16


<210> 13111
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13111
cuguccaagc ccggu                                                        15


<210> 13112
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13112
cuguccaagc ccgg                                                         14


<210> 13113
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13113
cuguccaagc ccg                                                          13


<210> 13114
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13114
cuguccaagc cc                                                           12


<210> 13115
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13115
cuguccaagc c                                                            11


<210> 13116
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13116
cuguccaagc                                                              10


<210> 13117
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13117
cuguccaag                                                                9


<210> 13118
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13118
cuguccaa                                                                 8


<210> 13119
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13119
guucugucca agcccgguug                                                   20


<210> 13120
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13120
guucugucca agcccgguu                                                    19


<210> 13121
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13121
guucugucca agcccggu                                                     18


<210> 13122
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13122
guucugucca agcccgg                                                      17


<210> 13123
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13123
guucugucca agcccg                                                       16


<210> 13124
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13124
guucugucca agccc                                                        15


<210> 13125
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13125
guucugucca agcc                                                         14


<210> 13126
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13126
guucugucca agc                                                          13


<210> 13127
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13127
guucugucca ag                                                           12


<210> 13128
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13128
guucugucca a                                                            11


<210> 13129
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13129
guucugucca                                                              10


<210> 13130
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13130
guucugucc                                                                9


<210> 13131
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13131
guucuguc                                                                 8


<210> 13132
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13132
aguucugucc aagcccgguu                                                   20


<210> 13133
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13133
aguucugucc aagcccggu                                                    19


<210> 13134
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13134
aguucugucc aagcccgg                                                     18


<210> 13135
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13135
aguucugucc aagcccg                                                      17


<210> 13136
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13136
aguucugucc aagccc                                                       16


<210> 13137
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13137
aguucugucc aagcc                                                        15


<210> 13138
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13138
aguucugucc aagc                                                         14


<210> 13139
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13139
aguucugucc aag                                                          13


<210> 13140
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13140
aguucugucc aa                                                           12


<210> 13141
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13141
aguucugucc a                                                            11


<210> 13142
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13142
aguucugucc                                                              10


<210> 13143
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13143
aguucuguc                                                                9


<210> 13144
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13144
aguucugu                                                                 8


<210> 13145
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13145
aaguucuguc caagcccggu                                                   20


<210> 13146
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13146
aaguucuguc caagcccgg                                                    19


<210> 13147
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13147
aaguucuguc caagcccg                                                     18


<210> 13148
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13148
aaguucuguc caagccc                                                      17


<210> 13149
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13149
aaguucuguc caagcc                                                       16


<210> 13150
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13150
aaguucuguc caagc                                                        15


<210> 13151
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13151
aaguucuguc caag                                                         14


<210> 13152
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13152
aaguucuguc caa                                                          13


<210> 13153
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13153
aaguucuguc ca                                                           12


<210> 13154
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13154
aaguucuguc c                                                            11


<210> 13155
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13155
aaguucuguc                                                              10


<210> 13156
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13156
aaguucugu                                                                9


<210> 13157
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13157
aaguucug                                                                 8


<210> 13158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13158
taaguucugu ccaagcccgg                                                   20


<210> 13159
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13159
taaguucugu ccaagcccg                                                    19


<210> 13160
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13160
taaguucugu ccaagccc                                                     18


<210> 13161
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13161
taaguucugu ccaagcc                                                      17


<210> 13162
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13162
taaguucugu ccaagc                                                       16


<210> 13163
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13163
taaguucugu ccaa                                                         14


<210> 13164
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13164
taaguucugu cca                                                          13


<210> 13165
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13165
taaguucugu cc                                                           12


<210> 13166
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13166
taaguucugu c                                                            11


<210> 13167
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13167
taaguucugu                                                              10


<210> 13168
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13168
taaguucug                                                                9


<210> 13169
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13169
taaguucu                                                                 8


<210> 13170
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13170
guaaguucug uccaagcccg                                                   20


<210> 13171
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13171
guaaguucug uccaagccc                                                    19


<210> 13172
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13172
guaaguucug uccaagc                                                      17


<210> 13173
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13173
guaaguucug uccaag                                                       16


<210> 13174
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13174
guaaguucug uccaa                                                        15


<210> 13175
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13175
guaaguucug ucca                                                         14


<210> 13176
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13176
guaaguucug ucc                                                          13


<210> 13177
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13177
guaaguucug uc                                                           12


<210> 13178
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13178
guaaguucug u                                                            11


<210> 13179
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13179
guaaguucug                                                              10


<210> 13180
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13180
guaaguucu                                                                9


<210> 13181
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13181
guaaguuc                                                                 8


<210> 13182
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13182
gguaaguucu guccaagccc                                                   20


<210> 13183
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13183
gguaaguucu guccaagcc                                                    19


<210> 13184
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13184
gguaaguucu guccaag                                                      17


<210> 13185
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13185
gguaaguucu guccaa                                                       16


<210> 13186
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13186
gguaaguucu gucca                                                        15


<210> 13187
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13187
gguaaguucu gucc                                                         14


<210> 13188
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13188
gguaaguucu guc                                                          13


<210> 13189
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13189
gguaaguucu gu                                                           12


<210> 13190
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13190
gguaaguucu g                                                            11


<210> 13191
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13191
gguaaguucu                                                              10


<210> 13192
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13192
gguaaguuc                                                                9


<210> 13193
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 13193
gguaaguu                                                                 8


<210> 13194
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13194
cgguaaguuc uguccaagcc                                                   20


<210> 13195
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13195
cgguaaguuc uguccaagc                                                    19


<210> 13196
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13196
cgguaaguuc uguccaag                                                     18


<210> 13197
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13197
cgguaaguuc uguccaa                                                      17


<210> 13198
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13198
cgguaaguuc ugucca                                                       16


<210> 13199
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13199
cgguaaguuc ugucc                                                        15


<210> 13200
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13200
cgguaaguuc uguc                                                         14


<210> 13201
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13201
cgguaaguuc ugu                                                          13


<210> 13202
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13202
cgguaaguuc ug                                                           12


<210> 13203
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13203
cgguaaguuc u                                                            11


<210> 13204
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13204
cgguaaguuc                                                              10


<210> 13205
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 13205
cgguaaguu                                                                9


<210> 13206
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 13206
cgguaagu                                                                 8


<210> 13207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13207
tcgguaaguu cuguccaagc                                                   20


<210> 13208
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13208
tcgguaaguu cuguccaag                                                    19


<210> 13209
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13209
tcgguaaguu cuguccaa                                                     18


<210> 13210
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13210
tcgguaaguu cugucca                                                      17


<210> 13211
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13211
tcgguaaguu cugucc                                                       16


<210> 13212
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13212
tcgguaaguu cuguc                                                        15


<210> 13213
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13213
tcgguaaguu cugu                                                         14


<210> 13214
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13214
tcgguaaguu cug                                                          13


<210> 13215
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13215
tcgguaaguu cu                                                           12


<210> 13216
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13216
tcgguaaguu c                                                            11


<210> 13217
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 13217
tcgguaaguu                                                              10


<210> 13218
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 13218
tcgguaagu                                                                9


<210> 13219
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13219
gucgguaagu ucuguccaag                                                   20


<210> 13220
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13220
gucgguaagu ucuguccaa                                                    19


<210> 13221
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13221
gucgguaagu ucugucca                                                     18


<210> 13222
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13222
gucgguaagu ucugucc                                                      17


<210> 13223
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13223
gucgguaagu ucuguc                                                       16


<210> 13224
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13224
gucgguaagu ucugu                                                        15


<210> 13225
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13225
gucgguaagu ucug                                                         14


<210> 13226
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13226
gucgguaagu ucu                                                          13


<210> 13227
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13227
gucgguaagu uc                                                           12


<210> 13228
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13228
gucgguaagu u                                                            11


<210> 13229
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13229
gucgguaagu                                                              10


<210> 13230
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13230
agucgguaag uucuguccaa                                                   20


<210> 13231
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13231
agucgguaag uucugucca                                                    19


<210> 13232
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13232
agucgguaag uucuguc                                                      17


<210> 13233
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13233
agucgguaag uucugu                                                       16


<210> 13234
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13234
agucgguaag uucug                                                        15


<210> 13235
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13235
agucgguaag uucu                                                         14


<210> 13236
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13236
agucgguaag uuc                                                          13


<210> 13237
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13237
agucgguaag uu                                                           12


<210> 13238
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13238
agucgguaag u                                                            11


<210> 13239
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13239
cagucgguaa guucugucca                                                   20


<210> 13240
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13240
cagucgguaa guucugucc                                                    19


<210> 13241
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13241
cagucgguaa guucuguc                                                     18


<210> 13242
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13242
cagucgguaa guucugu                                                      17


<210> 13243
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13243
cagucgguaa guucug                                                       16


<210> 13244
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13244
cagucgguaa guucu                                                        15


<210> 13245
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13245
cagucgguaa guuc                                                         14


<210> 13246
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13246
cagucgguaa guu                                                          13


<210> 13247
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13247
cagucgguaa gu                                                           12


<210> 13248
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13248
ccagucggua aguucugucc                                                   20


<210> 13249
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13249
ccagucggua aguucuguc                                                    19


<210> 13250
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13250
ccagucggua aguucugu                                                     18


<210> 13251
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13251
ccagucggua aguucug                                                      17


<210> 13252
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13252
ccagucggua aguucu                                                       16


<210> 13253
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13253
ccagucggua aguuc                                                        15


<210> 13254
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13254
ccagucggua aguu                                                         14


<210> 13255
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13255
ccagucggua agu                                                          13


<210> 13256
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13256
gccagucggu aaguucuguc                                                   20


<210> 13257
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13257
gccagucggu aaguucugu                                                    19


<210> 13258
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13258
gccagucggu aaguucug                                                     18


<210> 13259
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13259
gccagucggu aaguucu                                                      17


<210> 13260
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13260
gccagucggu aaguuc                                                       16


<210> 13261
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13261
gccagucggu aaguu                                                        15


<210> 13262
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13262
gccagucggu aagu                                                         14


<210> 13263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13263
tcaaggaaga uggcauuucu                                                   20


<210> 13264
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13264
tcaaggaaga uggcauuucu ag                                                22


<210> 13265
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13265
tcaaggaaga uggcau                                                       16


<210> 13266
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13266
gaagauggca uuucu                                                        15


<210> 13267
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13267
tcaaggaaga uggcauuucu a                                                 21


<210> 13268
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13268
tcaaggaaga uggcauuuc                                                    19


<210> 13269
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13269
tcaaggaaga uggcauuu                                                     18


<210> 13270
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13270
tcaaggaaga uggcauu                                                      17


<210> 13271
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13271
tcaaggaaga uggca                                                        15


<210> 13272
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13272
tcaaggaaga uggc                                                         14


<210> 13273
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 13273
tcaaggaaga ugg                                                          13


<210> 13274
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 13274
tcaaggaaga ug                                                           12


<210> 13275
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 13275
tcaaggaaga u                                                            11


<210> 13276
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 13276
tcaaggaaga                                                              10


<210> 13277
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<400> 13277
tcaaggaag                                                                9


<210> 13278
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13278
caaggaagau ggcauuucua g                                                 21


<210> 13279
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13279
caaggaagau ggcauuucua                                                   20


<210> 13280
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13280
caaggaagau ggcauuucu                                                    19


<210> 13281
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13281
caaggaagau ggcauuuc                                                     18


<210> 13282
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13282
caaggaagau ggcauuu                                                      17


<210> 13283
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13283
caaggaagau ggcauu                                                       16


<210> 13284
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13284
caaggaagau ggcau                                                        15


<210> 13285
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13285
caaggaagau ggca                                                         14


<210> 13286
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13286
caaggaagau ggc                                                          13


<210> 13287
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 13287
caaggaagau gg                                                           12


<210> 13288
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 13288
caaggaagau g                                                            11


<210> 13289
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 13289
caaggaagau                                                              10


<210> 13290
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 13290
caaggaaga                                                                9


<210> 13291
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<400> 13291
caaggaag                                                                 8


<210> 13292
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13292
aaggaagaug gcauuucuag                                                   20


<210> 13293
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13293
aaggaagaug gcauuucua                                                    19


<210> 13294
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13294
aaggaagaug gcauuucu                                                     18


<210> 13295
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13295
aaggaagaug gcauuuc                                                      17


<210> 13296
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13296
aaggaagaug gcauuu                                                       16


<210> 13297
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13297
aaggaagaug gcauu                                                        15


<210> 13298
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13298
aaggaagaug gcau                                                         14


<210> 13299
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13299
aaggaagaug gca                                                          13


<210> 13300
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13300
aaggaagaug gc                                                           12


<210> 13301
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 13301
aaggaagaug g                                                            11


<210> 13302
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 13302
aaggaagaug                                                              10


<210> 13303
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 13303
aaggaagau                                                                9


<210> 13304
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 13304
aaggaaga                                                                 8


<210> 13305
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13305
aggaagaugg cauuucuag                                                    19


<210> 13306
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13306
aggaagaugg cauuucua                                                     18


<210> 13307
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13307
aggaagaugg cauuucu                                                      17


<210> 13308
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13308
aggaagaugg cauuuc                                                       16


<210> 13309
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13309
aggaagaugg cauuu                                                        15


<210> 13310
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13310
aggaagaugg cauu                                                         14


<210> 13311
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13311
aggaagaugg cau                                                          13


<210> 13312
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 13312
aggaagaugg ca                                                           12


<210> 13313
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 13313
aggaagaugg                                                              10


<210> 13314
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 13314
aggaagaug                                                                9


<210> 13315
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 13315
aggaagau                                                                 8


<210> 13316
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13316
ggaagauggc auuucuag                                                     18


<210> 13317
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13317
ggaagauggc auuucua                                                      17


<210> 13318
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13318
ggaagauggc auuucu                                                       16


<210> 13319
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13319
ggaagauggc auuuc                                                        15


<210> 13320
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13320
ggaagauggc auuu                                                         14


<210> 13321
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13321
ggaagauggc auu                                                          13


<210> 13322
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13322
ggaagauggc au                                                           12


<210> 13323
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13323
ggaagauggc a                                                            11


<210> 13324
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13324
ggaagauggc                                                              10


<210> 13325
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 13325
ggaagaug                                                                 8


<210> 13326
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13326
gaagauggca uuucuag                                                      17


<210> 13327
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13327
gaagauggca uuucua                                                       16


<210> 13328
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 13328
gaagauggca uuuc                                                         14


<210> 13329
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13329
gaagauggca uuu                                                          13


<210> 13330
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13330
gaagauggca uu                                                           12


<210> 13331
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13331
gaagauggca u                                                            11


<210> 13332
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13332
gaagauggca                                                              10


<210> 13333
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13333
gaagauggc                                                                9


<210> 13334
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 13334
gaagaugg                                                                 8


<210> 13335
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13335
aagauggcau uucuag                                                       16


<210> 13336
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13336
aagauggcau uucua                                                        15


<210> 13337
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13337
aagauggcau uucu                                                         14


<210> 13338
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 13338
aagauggcau uuc                                                          13


<210> 13339
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13339
aagauggcau uu                                                           12


<210> 13340
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13340
aagauggcau u                                                            11


<210> 13341
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13341
aagauggcau                                                              10


<210> 13342
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13342
aagauggca                                                                9


<210> 13343
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13343
aagauggc                                                                 8


<210> 13344
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13344
agauggcauu ucuag                                                        15


<210> 13345
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13345
agauggcauu ucua                                                         14


<210> 13346
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13346
agauggcauu ucu                                                          13


<210> 13347
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 13347
agauggcauu uc                                                           12


<210> 13348
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13348
agauggcauu u                                                            11


<210> 13349
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13349
agauggcauu                                                              10


<210> 13350
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13350
agauggcau                                                                9


<210> 13351
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13351
agauggca                                                                 8


<210> 13352
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 13352
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 13353
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 13353
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 13354
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 13354
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 13355
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 13355
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 13356
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13356
cuccaacauc aaggaagaug gcauuu                                            26


<210> 13357
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13357
cuccaacauc aaggaagaug gcauu                                             25


<210> 13358
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13358
cuccaacauc aaggaagaug gcau                                              24


<210> 13359
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13359
cuccaacauc aaggaagaug gca                                               23


<210> 13360
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13360
cuccaacauc aaggaagaug gc                                                22


<210> 13361
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13361
cuccaacauc aaggaagaug g                                                 21


<210> 13362
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13362
cuccaacauc aaggaagaug                                                   20


<210> 13363
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13363
cuccaacauc aaggaagau                                                    19


<210> 13364
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13364
cuccaacauc aaggaaga                                                     18


<210> 13365
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 13365
cuccaacauc aaggaag                                                      17


<210> 13366
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 13366
tccaacauca aggaagaugg cauuucuag                                         29


<210> 13367
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 13367
tccaacauca aggaagaugg cauuucua                                          28


<210> 13368
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 13368
tccaacauca aggaagaugg cauuucu                                           27


<210> 13369
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 13369
tccaacauca aggaagaugg cauuuc                                            26


<210> 13370
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13370
tccaacauca aggaagaugg cauuu                                             25


<210> 13371
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13371
tccaacauca aggaagaugg cauu                                              24


<210> 13372
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13372
tccaacauca aggaagaugg cau                                               23


<210> 13373
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13373
tccaacauca aggaagaugg ca                                                22


<210> 13374
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13374
tccaacauca aggaagaugg c                                                 21


<210> 13375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13375
tccaacauca aggaagaugg                                                   20


<210> 13376
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13376
tccaacauca aggaagaug                                                    19


<210> 13377
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13377
tccaacauca aggaagau                                                     18


<210> 13378
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13378
tccaacauca aggaaga                                                      17


<210> 13379
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 13379
tccaacauca aggaag                                                       16


<210> 13380
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 13380
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 13381
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 13381
ccaacaucaa ggaagauggc auuucua                                           27


<210> 13382
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 13382
ccaacaucaa ggaagauggc auuucu                                            26


<210> 13383
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 13383
ccaacaucaa ggaagauggc auuuc                                             25


<210> 13384
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13384
ccaacaucaa ggaagauggc auuu                                              24


<210> 13385
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13385
ccaacaucaa ggaagauggc auu                                               23


<210> 13386
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13386
ccaacaucaa ggaagauggc au                                                22


<210> 13387
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13387
ccaacaucaa ggaagauggc a                                                 21


<210> 13388
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13388
ccaacaucaa ggaagauggc                                                   20


<210> 13389
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13389
ccaacaucaa ggaagaugg                                                    19


<210> 13390
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13390
ccaacaucaa ggaagaug                                                     18


<210> 13391
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13391
ccaacaucaa ggaagau                                                      17


<210> 13392
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13392
ccaacaucaa ggaaga                                                       16


<210> 13393
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 13393
ccaacaucaa ggaag                                                        15


<210> 13394
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 13394
caacaucaag gaagauggca uuucuag                                           27


<210> 13395
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 13395
caacaucaag gaagauggca uuucua                                            26


<210> 13396
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 13396
caacaucaag gaagauggca uuucu                                             25


<210> 13397
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 13397
caacaucaag gaagauggca uuuc                                              24


<210> 13398
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13398
caacaucaag gaagauggca uuu                                               23


<210> 13399
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13399
caacaucaag gaagauggca uu                                                22


<210> 13400
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13400
caacaucaag gaagauggca u                                                 21


<210> 13401
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13401
caacaucaag gaagauggca                                                   20


<210> 13402
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 13402
caacaucaag gaagauggc                                                    19


<210> 13403
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13403
caacaucaag gaagaugg                                                     18


<210> 13404
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13404
caacaucaag gaagaug                                                      17


<210> 13405
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13405
caacaucaag gaagau                                                       16


<210> 13406
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13406
caacaucaag gaaga                                                        15


<210> 13407
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 13407
caacaucaag gaag                                                         14


<210> 13408
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 13408
aacaucaagg aagauggcau uucuag                                            26


<210> 13409
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 13409
aacaucaagg aagauggcau uucua                                             25


<210> 13410
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 13410
aacaucaagg aagauggcau uucu                                              24


<210> 13411
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 13411
aacaucaagg aagauggcau uuc                                               23


<210> 13412
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13412
aacaucaagg aagauggcau uu                                                22


<210> 13413
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13413
aacaucaagg aagauggcau u                                                 21


<210> 13414
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13414
aacaucaagg aagauggcau                                                   20


<210> 13415
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13415
aacaucaagg aagauggca                                                    19


<210> 13416
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13416
aacaucaagg aagauggc                                                     18


<210> 13417
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13417
aacaucaagg aagaugg                                                      17


<210> 13418
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13418
aacaucaagg aagaug                                                       16


<210> 13419
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13419
aacaucaagg aagau                                                        15


<210> 13420
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13420
aacaucaagg aaga                                                         14


<210> 13421
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 13421
aacaucaagg aag                                                          13


<210> 13422
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13422
acaucaagga agauggcauu ucuag                                             25


<210> 13423
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13423
acaucaagga agauggcauu ucua                                              24


<210> 13424
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13424
acaucaagga agauggcauu ucu                                               23


<210> 13425
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 13425
acaucaagga agauggcauu uc                                                22


<210> 13426
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13426
acaucaagga agauggcauu u                                                 21


<210> 13427
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13427
acaucaagga agauggcauu                                                   20


<210> 13428
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13428
acaucaagga agauggcau                                                    19


<210> 13429
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13429
acaucaagga agauggca                                                     18


<210> 13430
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13430
acaucaagga agauggc                                                      17


<210> 13431
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13431
acaucaagga agaugg                                                       16


<210> 13432
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13432
acaucaagga agaug                                                        15


<210> 13433
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13433
acaucaagga agau                                                         14


<210> 13434
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13434
acaucaagga aga                                                          13


<210> 13435
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 13435
acaucaagga ag                                                           12


<210> 13436
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13436
caucaaggaa gauggcauuu cuag                                              24


<210> 13437
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13437
caucaaggaa gauggcauuu cua                                               23


<210> 13438
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13438
caucaaggaa gauggcauuu cu                                                22


<210> 13439
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 13439
caucaaggaa gauggcauuu c                                                 21


<210> 13440
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13440
caucaaggaa gauggcauuu                                                   20


<210> 13441
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13441
caucaaggaa gauggcauu                                                    19


<210> 13442
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13442
caucaaggaa gauggcau                                                     18


<210> 13443
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13443
caucaaggaa gauggca                                                      17


<210> 13444
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13444
caucaaggaa gauggc                                                       16


<210> 13445
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13445
caucaaggaa gaugg                                                        15


<210> 13446
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13446
caucaaggaa gaug                                                         14


<210> 13447
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13447
caucaaggaa gau                                                          13


<210> 13448
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13448
caucaaggaa ga                                                           12


<210> 13449
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 13449
caucaaggaa g                                                            11


<210> 13450
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13450
aucaaggaag auggcauuuc uag                                               23


<210> 13451
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13451
aucaaggaag auggcauuuc ua                                                22


<210> 13452
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13452
aucaaggaag auggcauuuc u                                                 21


<210> 13453
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13453
aucaaggaag auggcauuuc                                                   20


<210> 13454
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13454
aucaaggaag auggcauuu                                                    19


<210> 13455
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13455
aucaaggaag auggcauu                                                     18


<210> 13456
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13456
aucaaggaag auggcau                                                      17


<210> 13457
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13457
aucaaggaag auggca                                                       16


<210> 13458
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 13458
aucaaggaag auggc                                                        15


<210> 13459
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13459
aucaaggaag augg                                                         14


<210> 13460
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13460
aucaaggaag aug                                                          13


<210> 13461
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13461
aucaaggaag au                                                           12


<210> 13462
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13462
aucaaggaag a                                                            11


<210> 13463
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 13463
aucaaggaag                                                              10


<210> 13464
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 13464
ccagagcagg uaccuccaac auc                                               23


<210> 13465
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13465
ccagagcagg uaccucca                                                     18


<210> 13466
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13466
ccucugugau uuuauaacuu gau                                               23


<210> 13467
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 13467
tcacccacca ucacccu                                                      17


<210> 13468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 13468
tgauauccuc aaggucaccc                                                   20


<210> 13469
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13469
cugcuugaug aucaucucgu ug                                                22


<210> 13470
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 13470
cugcuugaug aucaucuc                                                     18


<210> 13471
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13471
guuuccuuag uaaccacag                                                    19


<210> 13472
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 13472
guuuccuuag uaaccac                                                      17


<210> 13473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13473
tcaaggaaga uggcauuucu                                                   20


<210> 13474
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13474
tcaaggaaga uggcauuucu ag                                                22


<210> 13475
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13475
gguaaguucu guccaagc                                                     18


<210> 13476
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13476
guaaguucug uccaagcc                                                     18


<210> 13477
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13477
agucgguaag uucugucc                                                     18


<210> 13478
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13478
cuguccaagc ccgguuga                                                     18


<210> 13479
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13479
taaguucugu ccaag                                                        15


<210> 13480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13480
tucuguccaa gcccgguuga                                                   20


<210> 13481
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13481
tucuguccaa gcccgguug                                                    19


<210> 13482
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13482
tucuguccaa gcccgguu                                                     18


<210> 13483
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13483
tucuguccaa gcccggu                                                      17


<210> 13484
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13484
tucuguccaa gcccgg                                                       16


<210> 13485
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13485
tucuguccaa gcccg                                                        15


<210> 13486
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13486
tucuguccaa gccc                                                         14


<210> 13487
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13487
tucuguccaa gcc                                                          13


<210> 13488
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13488
tucuguccaa gc                                                           12


<210> 13489
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13489
tucuguccaa g                                                            11


<210> 13490
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13490
tucuguccaa                                                              10


<210> 13491
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13491
tucugucca                                                                9


<210> 13492
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13492
tucugucc                                                                 8


<210> 13493
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13493
tcuguccaag cccgguuga                                                    19


<210> 13494
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13494
tcuguccaag cccgguug                                                     18


<210> 13495
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13495
tcuguccaag cccgguu                                                      17


<210> 13496
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13496
tcuguccaag cccggu                                                       16


<210> 13497
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13497
tcuguccaag cccgg                                                        15


<210> 13498
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13498
tcuguccaag cccg                                                         14


<210> 13499
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13499
tcuguccaag ccc                                                          13


<210> 13500
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13500
tcuguccaag cc                                                           12


<210> 13501
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13501
tcuguccaag c                                                            11


<210> 13502
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13502
tcuguccaag                                                              10


<210> 13503
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13503
tcuguccaa                                                                9


<210> 13504
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13504
tcugucca                                                                 8


<210> 13505
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13505
cuguccaagc ccgguug                                                      17


<210> 13506
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13506
cuguccaagc ccgguu                                                       16


<210> 13507
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13507
cuguccaagc ccggu                                                        15


<210> 13508
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13508
cuguccaagc ccgg                                                         14


<210> 13509
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13509
cuguccaagc ccg                                                          13


<210> 13510
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13510
cuguccaagc cc                                                           12


<210> 13511
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13511
cuguccaagc c                                                            11


<210> 13512
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13512
cuguccaagc                                                              10


<210> 13513
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13513
cuguccaag                                                                9


<210> 13514
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13514
cuguccaa                                                                 8


<210> 13515
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13515
guucugucca agcccgguug                                                   20


<210> 13516
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13516
guucugucca agcccgguu                                                    19


<210> 13517
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13517
guucugucca agcccggu                                                     18


<210> 13518
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13518
guucugucca agcccgg                                                      17


<210> 13519
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13519
guucugucca agcccg                                                       16


<210> 13520
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13520
guucugucca agccc                                                        15


<210> 13521
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13521
guucugucca agcc                                                         14


<210> 13522
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13522
guucugucca agc                                                          13


<210> 13523
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13523
guucugucca ag                                                           12


<210> 13524
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13524
guucugucca a                                                            11


<210> 13525
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13525
guucugucca                                                              10


<210> 13526
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13526
guucugucc                                                                9


<210> 13527
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13527
guucuguc                                                                 8


<210> 13528
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13528
aguucugucc aagcccgguu                                                   20


<210> 13529
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13529
aguucugucc aagcccggu                                                    19


<210> 13530
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13530
aguucugucc aagcccgg                                                     18


<210> 13531
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13531
aguucugucc aagcccg                                                      17


<210> 13532
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13532
aguucugucc aagccc                                                       16


<210> 13533
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13533
aguucugucc aagcc                                                        15


<210> 13534
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13534
aguucugucc aagc                                                         14


<210> 13535
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13535
aguucugucc aag                                                          13


<210> 13536
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13536
aguucugucc aa                                                           12


<210> 13537
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13537
aguucugucc a                                                            11


<210> 13538
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13538
aguucugucc                                                              10


<210> 13539
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13539
aguucuguc                                                                9


<210> 13540
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13540
aguucugu                                                                 8


<210> 13541
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13541
aaguucuguc caagcccggu                                                   20


<210> 13542
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13542
aaguucuguc caagcccgg                                                    19


<210> 13543
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13543
aaguucuguc caagcccg                                                     18


<210> 13544
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13544
aaguucuguc caagccc                                                      17


<210> 13545
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13545
aaguucuguc caagcc                                                       16


<210> 13546
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13546
aaguucuguc caagc                                                        15


<210> 13547
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13547
aaguucuguc caag                                                         14


<210> 13548
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13548
aaguucuguc caa                                                          13


<210> 13549
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13549
aaguucuguc ca                                                           12


<210> 13550
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13550
aaguucuguc c                                                            11


<210> 13551
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13551
aaguucuguc                                                              10


<210> 13552
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13552
aaguucugu                                                                9


<210> 13553
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13553
aaguucug                                                                 8


<210> 13554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13554
taaguucugu ccaagcccgg                                                   20


<210> 13555
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13555
taaguucugu ccaagcccg                                                    19


<210> 13556
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13556
taaguucugu ccaagccc                                                     18


<210> 13557
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13557
taaguucugu ccaagcc                                                      17


<210> 13558
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13558
taaguucugu ccaagc                                                       16


<210> 13559
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13559
taaguucugu ccaa                                                         14


<210> 13560
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13560
taaguucugu cca                                                          13


<210> 13561
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13561
taaguucugu cc                                                           12


<210> 13562
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13562
taaguucugu c                                                            11


<210> 13563
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13563
taaguucugu                                                              10


<210> 13564
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13564
taaguucug                                                                9


<210> 13565
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13565
taaguucu                                                                 8


<210> 13566
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13566
guaaguucug uccaagcccg                                                   20


<210> 13567
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13567
guaaguucug uccaagccc                                                    19


<210> 13568
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13568
guaaguucug uccaagc                                                      17


<210> 13569
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13569
guaaguucug uccaag                                                       16


<210> 13570
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13570
guaaguucug uccaa                                                        15


<210> 13571
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13571
guaaguucug ucca                                                         14


<210> 13572
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13572
guaaguucug ucc                                                          13


<210> 13573
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13573
guaaguucug uc                                                           12


<210> 13574
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13574
guaaguucug u                                                            11


<210> 13575
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13575
guaaguucug                                                              10


<210> 13576
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13576
guaaguucu                                                                9


<210> 13577
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13577
guaaguuc                                                                 8


<210> 13578
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13578
gguaaguucu guccaagccc                                                   20


<210> 13579
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13579
gguaaguucu guccaagcc                                                    19


<210> 13580
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13580
gguaaguucu guccaag                                                      17


<210> 13581
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13581
gguaaguucu guccaa                                                       16


<210> 13582
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13582
gguaaguucu gucca                                                        15


<210> 13583
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13583
gguaaguucu gucc                                                         14


<210> 13584
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13584
gguaaguucu guc                                                          13


<210> 13585
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13585
gguaaguucu gu                                                           12


<210> 13586
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13586
gguaaguucu g                                                            11


<210> 13587
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13587
gguaaguucu                                                              10


<210> 13588
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13588
gguaaguuc                                                                9


<210> 13589
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13589
gguaaguu                                                                 8


<210> 13590
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13590
cgguaaguuc uguccaagcc                                                   20


<210> 13591
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13591
cgguaaguuc uguccaagc                                                    19


<210> 13592
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13592
cgguaaguuc uguccaag                                                     18


<210> 13593
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13593
cgguaaguuc uguccaa                                                      17


<210> 13594
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13594
cgguaaguuc ugucca                                                       16


<210> 13595
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13595
cgguaaguuc ugucc                                                        15


<210> 13596
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13596
cgguaaguuc uguc                                                         14


<210> 13597
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13597
cgguaaguuc ugu                                                          13


<210> 13598
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13598
cgguaaguuc ug                                                           12


<210> 13599
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13599
cgguaaguuc u                                                            11


<210> 13600
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13600
cgguaaguuc                                                              10


<210> 13601
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13601
cgguaaguu                                                                9


<210> 13602
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13602
cgguaagu                                                                 8


<210> 13603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13603
tcgguaaguu cuguccaagc                                                   20


<210> 13604
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13604
tcgguaaguu cuguccaag                                                    19


<210> 13605
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13605
tcgguaaguu cuguccaa                                                     18


<210> 13606
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13606
tcgguaaguu cugucca                                                      17


<210> 13607
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13607
tcgguaaguu cugucc                                                       16


<210> 13608
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13608
tcgguaaguu cuguc                                                        15


<210> 13609
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13609
tcgguaaguu cugu                                                         14


<210> 13610
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13610
tcgguaaguu cug                                                          13


<210> 13611
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13611
tcgguaaguu cu                                                           12


<210> 13612
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13612
tcgguaaguu c                                                            11


<210> 13613
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13613
tcgguaaguu                                                              10


<210> 13614
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13614
tcgguaagu                                                                9


<210> 13615
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13615
gucgguaagu ucuguccaag                                                   20


<210> 13616
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13616
gucgguaagu ucuguccaa                                                    19


<210> 13617
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13617
gucgguaagu ucugucca                                                     18


<210> 13618
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13618
gucgguaagu ucugucc                                                      17


<210> 13619
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13619
gucgguaagu ucuguc                                                       16


<210> 13620
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13620
gucgguaagu ucugu                                                        15


<210> 13621
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13621
gucgguaagu ucug                                                         14


<210> 13622
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13622
gucgguaagu ucu                                                          13


<210> 13623
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13623
gucgguaagu uc                                                           12


<210> 13624
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13624
gucgguaagu u                                                            11


<210> 13625
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13625
gucgguaagu                                                              10


<210> 13626
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13626
agucgguaag uucuguccaa                                                   20


<210> 13627
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13627
agucgguaag uucugucca                                                    19


<210> 13628
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13628
agucgguaag uucuguc                                                      17


<210> 13629
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13629
agucgguaag uucugu                                                       16


<210> 13630
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13630
agucgguaag uucug                                                        15


<210> 13631
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13631
agucgguaag uucu                                                         14


<210> 13632
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13632
agucgguaag uuc                                                          13


<210> 13633
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13633
agucgguaag uu                                                           12


<210> 13634
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13634
agucgguaag u                                                            11


<210> 13635
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13635
cagucgguaa guucugucca                                                   20


<210> 13636
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13636
cagucgguaa guucugucc                                                    19


<210> 13637
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13637
cagucgguaa guucuguc                                                     18


<210> 13638
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13638
cagucgguaa guucugu                                                      17


<210> 13639
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13639
cagucgguaa guucug                                                       16


<210> 13640
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13640
cagucgguaa guucu                                                        15


<210> 13641
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13641
cagucgguaa guuc                                                         14


<210> 13642
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13642
cagucgguaa guu                                                          13


<210> 13643
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13643
cagucgguaa gu                                                           12


<210> 13644
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13644
ccagucggua aguucugucc                                                   20


<210> 13645
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13645
ccagucggua aguucuguc                                                    19


<210> 13646
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13646
ccagucggua aguucugu                                                     18


<210> 13647
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13647
ccagucggua aguucug                                                      17


<210> 13648
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13648
ccagucggua aguucu                                                       16


<210> 13649
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13649
ccagucggua aguuc                                                        15


<210> 13650
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13650
ccagucggua aguu                                                         14


<210> 13651
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13651
ccagucggua agu                                                          13


<210> 13652
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13652
gccagucggu aaguucuguc                                                   20


<210> 13653
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13653
gccagucggu aaguucugu                                                    19


<210> 13654
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13654
gccagucggu aaguucug                                                     18


<210> 13655
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13655
gccagucggu aaguucu                                                      17


<210> 13656
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13656
gccagucggu aaguuc                                                       16


<210> 13657
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13657
gccagucggu aaguu                                                        15


<210> 13658
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13658
gccagucggu aagu                                                         14


<210> 13659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13659
tcaaggaaga uggcauuucu                                                   20


<210> 13660
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13660
tcaaggaaga uggcauuucu ag                                                22


<210> 13661
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13661
tcaaggaaga uggcau                                                       16


<210> 13662
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13662
gaagauggca uuucu                                                        15


<210> 13663
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13663
tcaaggaaga uggcauuucu a                                                 21


<210> 13664
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13664
tcaaggaaga uggcauuuc                                                    19


<210> 13665
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13665
tcaaggaaga uggcauuu                                                     18


<210> 13666
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13666
tcaaggaaga uggcauu                                                      17


<210> 13667
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13667
tcaaggaaga uggca                                                        15


<210> 13668
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13668
tcaaggaaga uggc                                                         14


<210> 13669
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13669
tcaaggaaga ugg                                                          13


<210> 13670
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13670
tcaaggaaga ug                                                           12


<210> 13671
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13671
tcaaggaaga u                                                            11


<210> 13672
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13672
tcaaggaaga                                                              10


<210> 13673
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13673
tcaaggaag                                                                9


<210> 13674
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13674
caaggaagau ggcauuucua g                                                 21


<210> 13675
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13675
caaggaagau ggcauuucua                                                   20


<210> 13676
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13676
caaggaagau ggcauuucu                                                    19


<210> 13677
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13677
caaggaagau ggcauuuc                                                     18


<210> 13678
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13678
caaggaagau ggcauuu                                                      17


<210> 13679
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13679
caaggaagau ggcauu                                                       16


<210> 13680
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13680
caaggaagau ggcau                                                        15


<210> 13681
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13681
caaggaagau ggca                                                         14


<210> 13682
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13682
caaggaagau ggc                                                          13


<210> 13683
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13683
caaggaagau gg                                                           12


<210> 13684
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13684
caaggaagau g                                                            11


<210> 13685
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13685
caaggaagau                                                              10


<210> 13686
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13686
caaggaaga                                                                9


<210> 13687
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13687
caaggaag                                                                 8


<210> 13688
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13688
aaggaagaug gcauuucuag                                                   20


<210> 13689
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13689
aaggaagaug gcauuucua                                                    19


<210> 13690
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13690
aaggaagaug gcauuucu                                                     18


<210> 13691
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13691
aaggaagaug gcauuuc                                                      17


<210> 13692
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13692
aaggaagaug gcauuu                                                       16


<210> 13693
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13693
aaggaagaug gcauu                                                        15


<210> 13694
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13694
aaggaagaug gcau                                                         14


<210> 13695
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13695
aaggaagaug gca                                                          13


<210> 13696
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13696
aaggaagaug gc                                                           12


<210> 13697
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13697
aaggaagaug g                                                            11


<210> 13698
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13698
aaggaagaug                                                              10


<210> 13699
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13699
aaggaagau                                                                9


<210> 13700
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13700
aaggaaga                                                                 8


<210> 13701
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13701
aggaagaugg cauuucuag                                                    19


<210> 13702
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13702
aggaagaugg cauuucua                                                     18


<210> 13703
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13703
aggaagaugg cauuucu                                                      17


<210> 13704
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13704
aggaagaugg cauuuc                                                       16


<210> 13705
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13705
aggaagaugg cauuu                                                        15


<210> 13706
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13706
aggaagaugg cauu                                                         14


<210> 13707
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13707
aggaagaugg cau                                                          13


<210> 13708
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13708
aggaagaugg ca                                                           12


<210> 13709
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13709
aggaagaugg                                                              10


<210> 13710
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13710
aggaagaug                                                                9


<210> 13711
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13711
aggaagau                                                                 8


<210> 13712
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13712
ggaagauggc auuucuag                                                     18


<210> 13713
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13713
ggaagauggc auuucua                                                      17


<210> 13714
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13714
ggaagauggc auuucu                                                       16


<210> 13715
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13715
ggaagauggc auuuc                                                        15


<210> 13716
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13716
ggaagauggc auuu                                                         14


<210> 13717
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13717
ggaagauggc auu                                                          13


<210> 13718
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13718
ggaagauggc au                                                           12


<210> 13719
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13719
ggaagauggc a                                                            11


<210> 13720
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13720
ggaagauggc                                                              10


<210> 13721
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13721
ggaagaug                                                                 8


<210> 13722
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13722
gaagauggca uuucuag                                                      17


<210> 13723
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13723
gaagauggca uuucua                                                       16


<210> 13724
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13724
gaagauggca uuuc                                                         14


<210> 13725
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13725
gaagauggca uuu                                                          13


<210> 13726
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13726
gaagauggca uu                                                           12


<210> 13727
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13727
gaagauggca u                                                            11


<210> 13728
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13728
gaagauggca                                                              10


<210> 13729
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13729
gaagauggc                                                                9


<210> 13730
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13730
gaagaugg                                                                 8


<210> 13731
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13731
aagauggcau uucuag                                                       16


<210> 13732
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13732
aagauggcau uucua                                                        15


<210> 13733
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13733
aagauggcau uucu                                                         14


<210> 13734
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13734
aagauggcau uuc                                                          13


<210> 13735
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13735
aagauggcau uu                                                           12


<210> 13736
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13736
aagauggcau u                                                            11


<210> 13737
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13737
aagauggcau                                                              10


<210> 13738
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13738
aagauggca                                                                9


<210> 13739
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13739
aagauggc                                                                 8


<210> 13740
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13740
agauggcauu ucuag                                                        15


<210> 13741
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13741
agauggcauu ucua                                                         14


<210> 13742
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13742
agauggcauu ucu                                                          13


<210> 13743
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13743
agauggcauu uc                                                           12


<210> 13744
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13744
agauggcauu u                                                            11


<210> 13745
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13745
agauggcauu                                                              10


<210> 13746
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13746
agauggcau                                                                9


<210> 13747
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13747
agauggca                                                                 8


<210> 13748
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13748
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 13749
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13749
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 13750
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13750
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 13751
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13751
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 13752
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13752
cuccaacauc aaggaagaug gcauuu                                            26


<210> 13753
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13753
cuccaacauc aaggaagaug gcauu                                             25


<210> 13754
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13754
cuccaacauc aaggaagaug gcau                                              24


<210> 13755
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13755
cuccaacauc aaggaagaug gca                                               23


<210> 13756
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13756
cuccaacauc aaggaagaug gc                                                22


<210> 13757
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13757
cuccaacauc aaggaagaug g                                                 21


<210> 13758
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13758
cuccaacauc aaggaagaug                                                   20


<210> 13759
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13759
cuccaacauc aaggaagau                                                    19


<210> 13760
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13760
cuccaacauc aaggaaga                                                     18


<210> 13761
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13761
cuccaacauc aaggaag                                                      17


<210> 13762
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13762
tccaacauca aggaagaugg cauuucuag                                         29


<210> 13763
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13763
tccaacauca aggaagaugg cauuucua                                          28


<210> 13764
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13764
tccaacauca aggaagaugg cauuucu                                           27


<210> 13765
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13765
tccaacauca aggaagaugg cauuuc                                            26


<210> 13766
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13766
tccaacauca aggaagaugg cauuu                                             25


<210> 13767
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13767
tccaacauca aggaagaugg cauu                                              24


<210> 13768
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13768
tccaacauca aggaagaugg cau                                               23


<210> 13769
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13769
tccaacauca aggaagaugg ca                                                22


<210> 13770
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13770
tccaacauca aggaagaugg c                                                 21


<210> 13771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13771
tccaacauca aggaagaugg                                                   20


<210> 13772
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13772
tccaacauca aggaagaug                                                    19


<210> 13773
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13773
tccaacauca aggaagau                                                     18


<210> 13774
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13774
tccaacauca aggaaga                                                      17


<210> 13775
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13775
tccaacauca aggaag                                                       16


<210> 13776
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13776
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 13777
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13777
ccaacaucaa ggaagauggc auuucua                                           27


<210> 13778
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13778
ccaacaucaa ggaagauggc auuucu                                            26


<210> 13779
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13779
ccaacaucaa ggaagauggc auuuc                                             25


<210> 13780
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13780
ccaacaucaa ggaagauggc auuu                                              24


<210> 13781
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13781
ccaacaucaa ggaagauggc auu                                               23


<210> 13782
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13782
ccaacaucaa ggaagauggc au                                                22


<210> 13783
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13783
ccaacaucaa ggaagauggc a                                                 21


<210> 13784
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13784
ccaacaucaa ggaagauggc                                                   20


<210> 13785
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13785
ccaacaucaa ggaagaugg                                                    19


<210> 13786
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13786
ccaacaucaa ggaagaug                                                     18


<210> 13787
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13787
ccaacaucaa ggaagau                                                      17


<210> 13788
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13788
ccaacaucaa ggaaga                                                       16


<210> 13789
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13789
ccaacaucaa ggaag                                                        15


<210> 13790
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13790
caacaucaag gaagauggca uuucuag                                           27


<210> 13791
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13791
caacaucaag gaagauggca uuucua                                            26


<210> 13792
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13792
caacaucaag gaagauggca uuucu                                             25


<210> 13793
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13793
caacaucaag gaagauggca uuuc                                              24


<210> 13794
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13794
caacaucaag gaagauggca uuu                                               23


<210> 13795
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13795
caacaucaag gaagauggca uu                                                22


<210> 13796
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13796
caacaucaag gaagauggca u                                                 21


<210> 13797
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13797
caacaucaag gaagauggca                                                   20


<210> 13798
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13798
caacaucaag gaagauggc                                                    19


<210> 13799
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13799
caacaucaag gaagaugg                                                     18


<210> 13800
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13800
caacaucaag gaagaug                                                      17


<210> 13801
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13801
caacaucaag gaagau                                                       16


<210> 13802
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13802
caacaucaag gaaga                                                        15


<210> 13803
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13803
caacaucaag gaag                                                         14


<210> 13804
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13804
aacaucaagg aagauggcau uucuag                                            26


<210> 13805
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13805
aacaucaagg aagauggcau uucua                                             25


<210> 13806
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13806
aacaucaagg aagauggcau uucu                                              24


<210> 13807
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13807
aacaucaagg aagauggcau uuc                                               23


<210> 13808
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13808
aacaucaagg aagauggcau uu                                                22


<210> 13809
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13809
aacaucaagg aagauggcau u                                                 21


<210> 13810
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13810
aacaucaagg aagauggcau                                                   20


<210> 13811
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13811
aacaucaagg aagauggca                                                    19


<210> 13812
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13812
aacaucaagg aagauggc                                                     18


<210> 13813
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13813
aacaucaagg aagaugg                                                      17


<210> 13814
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13814
aacaucaagg aagaug                                                       16


<210> 13815
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13815
aacaucaagg aagau                                                        15


<210> 13816
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13816
aacaucaagg aaga                                                         14


<210> 13817
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13817
aacaucaagg aag                                                          13


<210> 13818
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13818
acaucaagga agauggcauu ucuag                                             25


<210> 13819
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13819
acaucaagga agauggcauu ucua                                              24


<210> 13820
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13820
acaucaagga agauggcauu ucu                                               23


<210> 13821
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13821
acaucaagga agauggcauu uc                                                22


<210> 13822
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13822
acaucaagga agauggcauu u                                                 21


<210> 13823
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13823
acaucaagga agauggcauu                                                   20


<210> 13824
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13824
acaucaagga agauggcau                                                    19


<210> 13825
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13825
acaucaagga agauggca                                                     18


<210> 13826
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13826
acaucaagga agauggc                                                      17


<210> 13827
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13827
acaucaagga agaugg                                                       16


<210> 13828
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13828
acaucaagga agaug                                                        15


<210> 13829
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13829
acaucaagga agau                                                         14


<210> 13830
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13830
acaucaagga aga                                                          13


<210> 13831
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13831
acaucaagga ag                                                           12


<210> 13832
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13832
caucaaggaa gauggcauuu cuag                                              24


<210> 13833
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13833
caucaaggaa gauggcauuu cua                                               23


<210> 13834
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13834
caucaaggaa gauggcauuu cu                                                22


<210> 13835
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13835
caucaaggaa gauggcauuu c                                                 21


<210> 13836
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13836
caucaaggaa gauggcauuu                                                   20


<210> 13837
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13837
caucaaggaa gauggcauu                                                    19


<210> 13838
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13838
caucaaggaa gauggcau                                                     18


<210> 13839
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13839
caucaaggaa gauggca                                                      17


<210> 13840
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13840
caucaaggaa gauggc                                                       16


<210> 13841
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13841
caucaaggaa gaugg                                                        15


<210> 13842
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13842
caucaaggaa gaug                                                         14


<210> 13843
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13843
caucaaggaa gau                                                          13


<210> 13844
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13844
caucaaggaa ga                                                           12


<210> 13845
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13845
caucaaggaa g                                                            11


<210> 13846
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13846
aucaaggaag auggcauuuc uag                                               23


<210> 13847
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13847
aucaaggaag auggcauuuc ua                                                22


<210> 13848
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13848
aucaaggaag auggcauuuc u                                                 21


<210> 13849
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13849
aucaaggaag auggcauuuc                                                   20


<210> 13850
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13850
aucaaggaag auggcauuu                                                    19


<210> 13851
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13851
aucaaggaag auggcauu                                                     18


<210> 13852
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13852
aucaaggaag auggcau                                                      17


<210> 13853
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13853
aucaaggaag auggca                                                       16


<210> 13854
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13854
aucaaggaag auggc                                                        15


<210> 13855
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13855
aucaaggaag augg                                                         14


<210> 13856
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13856
aucaaggaag aug                                                          13


<210> 13857
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13857
aucaaggaag au                                                           12


<210> 13858
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13858
aucaaggaag a                                                            11


<210> 13859
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13859
aucaaggaag                                                              10


<210> 13860
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13860
ccagagcagg uaccuccaac auc                                               23


<210> 13861
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13861
ccagagcagg uaccucca                                                     18


<210> 13862
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13862
ccucugugau uuuauaacuu gau                                               23


<210> 13863
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13863
tcacccacca ucacccu                                                      17


<210> 13864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13864
tgauauccuc aaggucaccc                                                   20


<210> 13865
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13865
cugcuugaug aucaucucgu ug                                                22


<210> 13866
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13866
cugcuugaug aucaucuc                                                     18


<210> 13867
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13867
guuuccuuag uaaccacag                                                    19


<210> 13868
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13868
guuuccuuag uaaccac                                                      17


<210> 13869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13869
tcaaggaaga uggcauuucu                                                   20


<210> 13870
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13870
tcaaggaaga uggcauuucu ag                                                22


<210> 13871
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13871
gguaaguucu guccaagc                                                     18


<210> 13872
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13872
guaaguucug uccaagcc                                                     18


<210> 13873
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13873
agucgguaag uucugucc                                                     18


<210> 13874
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13874
cuguccaagc ccgguuga                                                     18


<210> 13875
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13875
taaguucugu ccaag                                                        15


<210> 13876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13876
tucuguccaa gcccgguuga                                                   20


<210> 13877
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13877
tucuguccaa gcccgguug                                                    19


<210> 13878
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13878
tucuguccaa gcccgguu                                                     18


<210> 13879
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13879
tucuguccaa gcccggu                                                      17


<210> 13880
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13880
tucuguccaa gcccgg                                                       16


<210> 13881
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13881
tucuguccaa gcccg                                                        15


<210> 13882
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13882
tucuguccaa gccc                                                         14


<210> 13883
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13883
tucuguccaa gcc                                                          13


<210> 13884
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13884
tucuguccaa gc                                                           12


<210> 13885
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13885
tucuguccaa g                                                            11


<210> 13886
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13886
tucuguccaa                                                              10


<210> 13887
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13887
tucugucca                                                                9


<210> 13888
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13888
tucugucc                                                                 8


<210> 13889
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13889
tcuguccaag cccgguuga                                                    19


<210> 13890
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13890
tcuguccaag cccgguug                                                     18


<210> 13891
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13891
tcuguccaag cccgguu                                                      17


<210> 13892
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13892
tcuguccaag cccggu                                                       16


<210> 13893
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13893
tcuguccaag cccgg                                                        15


<210> 13894
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13894
tcuguccaag cccg                                                         14


<210> 13895
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13895
tcuguccaag ccc                                                          13


<210> 13896
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13896
tcuguccaag cc                                                           12


<210> 13897
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13897
tcuguccaag c                                                            11


<210> 13898
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13898
tcuguccaag                                                              10


<210> 13899
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13899
tcuguccaa                                                                9


<210> 13900
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13900
tcugucca                                                                 8


<210> 13901
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13901
cuguccaagc ccgguug                                                      17


<210> 13902
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13902
cuguccaagc ccgguu                                                       16


<210> 13903
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13903
cuguccaagc ccggu                                                        15


<210> 13904
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13904
cuguccaagc ccgg                                                         14


<210> 13905
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13905
cuguccaagc ccg                                                          13


<210> 13906
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13906
cuguccaagc cc                                                           12


<210> 13907
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13907
cuguccaagc c                                                            11


<210> 13908
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13908
cuguccaagc                                                              10


<210> 13909
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13909
cuguccaag                                                                9


<210> 13910
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13910
cuguccaa                                                                 8


<210> 13911
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13911
guucugucca agcccgguug                                                   20


<210> 13912
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13912
guucugucca agcccgguu                                                    19


<210> 13913
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13913
guucugucca agcccggu                                                     18


<210> 13914
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13914
guucugucca agcccgg                                                      17


<210> 13915
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13915
guucugucca agcccg                                                       16


<210> 13916
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13916
guucugucca agccc                                                        15


<210> 13917
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13917
guucugucca agcc                                                         14


<210> 13918
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13918
guucugucca agc                                                          13


<210> 13919
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13919
guucugucca ag                                                           12


<210> 13920
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13920
guucugucca a                                                            11


<210> 13921
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13921
guucugucca                                                              10


<210> 13922
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13922
guucugucc                                                                9


<210> 13923
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13923
guucuguc                                                                 8


<210> 13924
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13924
aguucugucc aagcccgguu                                                   20


<210> 13925
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13925
aguucugucc aagcccggu                                                    19


<210> 13926
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13926
aguucugucc aagcccgg                                                     18


<210> 13927
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13927
aguucugucc aagcccg                                                      17


<210> 13928
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13928
aguucugucc aagccc                                                       16


<210> 13929
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13929
aguucugucc aagcc                                                        15


<210> 13930
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13930
aguucugucc aagc                                                         14


<210> 13931
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13931
aguucugucc aag                                                          13


<210> 13932
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13932
aguucugucc aa                                                           12


<210> 13933
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13933
aguucugucc a                                                            11


<210> 13934
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13934
aguucugucc                                                              10


<210> 13935
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13935
aguucuguc                                                                9


<210> 13936
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13936
aguucugu                                                                 8


<210> 13937
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13937
aaguucuguc caagcccggu                                                   20


<210> 13938
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13938
aaguucuguc caagcccgg                                                    19


<210> 13939
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13939
aaguucuguc caagcccg                                                     18


<210> 13940
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13940
aaguucuguc caagccc                                                      17


<210> 13941
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13941
aaguucuguc caagcc                                                       16


<210> 13942
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13942
aaguucuguc caagc                                                        15


<210> 13943
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13943
aaguucuguc caag                                                         14


<210> 13944
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13944
aaguucuguc caa                                                          13


<210> 13945
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13945
aaguucuguc ca                                                           12


<210> 13946
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13946
aaguucuguc c                                                            11


<210> 13947
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13947
aaguucuguc                                                              10


<210> 13948
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13948
aaguucugu                                                                9


<210> 13949
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13949
aaguucug                                                                 8


<210> 13950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13950
taaguucugu ccaagcccgg                                                   20


<210> 13951
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13951
taaguucugu ccaagcccg                                                    19


<210> 13952
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13952
taaguucugu ccaagccc                                                     18


<210> 13953
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13953
taaguucugu ccaagcc                                                      17


<210> 13954
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13954
taaguucugu ccaagc                                                       16


<210> 13955
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13955
taaguucugu ccaa                                                         14


<210> 13956
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13956
taaguucugu cca                                                          13


<210> 13957
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13957
taaguucugu cc                                                           12


<210> 13958
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13958
taaguucugu c                                                            11


<210> 13959
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13959
taaguucugu                                                              10


<210> 13960
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13960
taaguucug                                                                9


<210> 13961
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13961
taaguucu                                                                 8


<210> 13962
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13962
guaaguucug uccaagcccg                                                   20


<210> 13963
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13963
guaaguucug uccaagccc                                                    19


<210> 13964
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13964
guaaguucug uccaagc                                                      17


<210> 13965
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13965
guaaguucug uccaag                                                       16


<210> 13966
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13966
guaaguucug uccaa                                                        15


<210> 13967
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13967
guaaguucug ucca                                                         14


<210> 13968
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13968
guaaguucug ucc                                                          13


<210> 13969
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13969
guaaguucug uc                                                           12


<210> 13970
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13970
guaaguucug u                                                            11


<210> 13971
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13971
guaaguucug                                                              10


<210> 13972
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13972
guaaguucu                                                                9


<210> 13973
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13973
guaaguuc                                                                 8


<210> 13974
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13974
gguaaguucu guccaagccc                                                   20


<210> 13975
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13975
gguaaguucu guccaagcc                                                    19


<210> 13976
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13976
gguaaguucu guccaag                                                      17


<210> 13977
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13977
gguaaguucu guccaa                                                       16


<210> 13978
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13978
gguaaguucu gucca                                                        15


<210> 13979
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13979
gguaaguucu gucc                                                         14


<210> 13980
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13980
gguaaguucu guc                                                          13


<210> 13981
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13981
gguaaguucu gu                                                           12


<210> 13982
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13982
gguaaguucu g                                                            11


<210> 13983
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13983
gguaaguucu                                                              10


<210> 13984
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13984
gguaaguuc                                                                9


<210> 13985
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13985
gguaaguu                                                                 8


<210> 13986
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13986
cgguaaguuc uguccaagcc                                                   20


<210> 13987
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13987
cgguaaguuc uguccaagc                                                    19


<210> 13988
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13988
cgguaaguuc uguccaag                                                     18


<210> 13989
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13989
cgguaaguuc uguccaa                                                      17


<210> 13990
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13990
cgguaaguuc ugucca                                                       16


<210> 13991
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13991
cgguaaguuc ugucc                                                        15


<210> 13992
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13992
cgguaaguuc uguc                                                         14


<210> 13993
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13993
cgguaaguuc ugu                                                          13


<210> 13994
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13994
cgguaaguuc ug                                                           12


<210> 13995
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13995
cgguaaguuc u                                                            11


<210> 13996
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13996
cgguaaguuc                                                              10


<210> 13997
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13997
cgguaaguu                                                                9


<210> 13998
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13998
cgguaagu                                                                 8


<210> 13999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 13999
tcgguaaguu cuguccaagc                                                   20


<210> 14000
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14000
tcgguaaguu cuguccaag                                                    19


<210> 14001
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14001
tcgguaaguu cuguccaa                                                     18


<210> 14002
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14002
tcgguaaguu cugucca                                                      17


<210> 14003
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14003
tcgguaaguu cugucc                                                       16


<210> 14004
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14004
tcgguaaguu cuguc                                                        15


<210> 14005
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14005
tcgguaaguu cugu                                                         14


<210> 14006
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14006
tcgguaaguu cug                                                          13


<210> 14007
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14007
tcgguaaguu cu                                                           12


<210> 14008
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14008
tcgguaaguu c                                                            11


<210> 14009
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14009
tcgguaaguu                                                              10


<210> 14010
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14010
tcgguaagu                                                                9


<210> 14011
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14011
gucgguaagu ucuguccaag                                                   20


<210> 14012
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14012
gucgguaagu ucuguccaa                                                    19


<210> 14013
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14013
gucgguaagu ucugucca                                                     18


<210> 14014
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14014
gucgguaagu ucugucc                                                      17


<210> 14015
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14015
gucgguaagu ucuguc                                                       16


<210> 14016
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14016
gucgguaagu ucugu                                                        15


<210> 14017
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14017
gucgguaagu ucug                                                         14


<210> 14018
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14018
gucgguaagu ucu                                                          13


<210> 14019
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14019
gucgguaagu uc                                                           12


<210> 14020
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14020
gucgguaagu u                                                            11


<210> 14021
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14021
gucgguaagu                                                              10


<210> 14022
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14022
agucgguaag uucuguccaa                                                   20


<210> 14023
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14023
agucgguaag uucugucca                                                    19


<210> 14024
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14024
agucgguaag uucuguc                                                      17


<210> 14025
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14025
agucgguaag uucugu                                                       16


<210> 14026
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14026
agucgguaag uucug                                                        15


<210> 14027
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14027
agucgguaag uucu                                                         14


<210> 14028
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14028
agucgguaag uuc                                                          13


<210> 14029
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14029
agucgguaag uu                                                           12


<210> 14030
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14030
agucgguaag u                                                            11


<210> 14031
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14031
cagucgguaa guucugucca                                                   20


<210> 14032
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14032
cagucgguaa guucugucc                                                    19


<210> 14033
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14033
cagucgguaa guucuguc                                                     18


<210> 14034
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14034
cagucgguaa guucugu                                                      17


<210> 14035
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14035
cagucgguaa guucug                                                       16


<210> 14036
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14036
cagucgguaa guucu                                                        15


<210> 14037
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14037
cagucgguaa guuc                                                         14


<210> 14038
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14038
cagucgguaa guu                                                          13


<210> 14039
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14039
cagucgguaa gu                                                           12


<210> 14040
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14040
ccagucggua aguucugucc                                                   20


<210> 14041
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14041
ccagucggua aguucuguc                                                    19


<210> 14042
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14042
ccagucggua aguucugu                                                     18


<210> 14043
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14043
ccagucggua aguucug                                                      17


<210> 14044
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14044
ccagucggua aguucu                                                       16


<210> 14045
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14045
ccagucggua aguuc                                                        15


<210> 14046
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14046
ccagucggua aguu                                                         14


<210> 14047
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14047
ccagucggua agu                                                          13


<210> 14048
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14048
gccagucggu aaguucuguc                                                   20


<210> 14049
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14049
gccagucggu aaguucugu                                                    19


<210> 14050
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14050
gccagucggu aaguucug                                                     18


<210> 14051
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14051
gccagucggu aaguucu                                                      17


<210> 14052
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14052
gccagucggu aaguuc                                                       16


<210> 14053
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14053
gccagucggu aaguu                                                        15


<210> 14054
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14054
gccagucggu aagu                                                         14


<210> 14055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14055
tcaaggaaga uggcauuucu                                                   20


<210> 14056
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14056
tcaaggaaga uggcauuucu ag                                                22


<210> 14057
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14057
tcaaggaaga uggcau                                                       16


<210> 14058
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14058
gaagauggca uuucu                                                        15


<210> 14059
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14059
tcaaggaaga uggcauuucu a                                                 21


<210> 14060
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14060
tcaaggaaga uggcauuuc                                                    19


<210> 14061
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14061
tcaaggaaga uggcauuu                                                     18


<210> 14062
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14062
tcaaggaaga uggcauu                                                      17


<210> 14063
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14063
tcaaggaaga uggca                                                        15


<210> 14064
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14064
tcaaggaaga uggc                                                         14


<210> 14065
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14065
tcaaggaaga ugg                                                          13


<210> 14066
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14066
tcaaggaaga ug                                                           12


<210> 14067
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14067
tcaaggaaga u                                                            11


<210> 14068
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14068
tcaaggaaga                                                              10


<210> 14069
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14069
tcaaggaag                                                                9


<210> 14070
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14070
caaggaagau ggcauuucua g                                                 21


<210> 14071
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14071
caaggaagau ggcauuucua                                                   20


<210> 14072
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14072
caaggaagau ggcauuucu                                                    19


<210> 14073
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14073
caaggaagau ggcauuuc                                                     18


<210> 14074
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14074
caaggaagau ggcauuu                                                      17


<210> 14075
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14075
caaggaagau ggcauu                                                       16


<210> 14076
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14076
caaggaagau ggcau                                                        15


<210> 14077
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14077
caaggaagau ggca                                                         14


<210> 14078
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14078
caaggaagau ggc                                                          13


<210> 14079
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14079
caaggaagau gg                                                           12


<210> 14080
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14080
caaggaagau g                                                            11


<210> 14081
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14081
caaggaagau                                                              10


<210> 14082
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14082
caaggaaga                                                                9


<210> 14083
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14083
caaggaag                                                                 8


<210> 14084
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14084
aaggaagaug gcauuucuag                                                   20


<210> 14085
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14085
aaggaagaug gcauuucua                                                    19


<210> 14086
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14086
aaggaagaug gcauuucu                                                     18


<210> 14087
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14087
aaggaagaug gcauuuc                                                      17


<210> 14088
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14088
aaggaagaug gcauuu                                                       16


<210> 14089
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14089
aaggaagaug gcauu                                                        15


<210> 14090
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14090
aaggaagaug gcau                                                         14


<210> 14091
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14091
aaggaagaug gca                                                          13


<210> 14092
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14092
aaggaagaug gc                                                           12


<210> 14093
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14093
aaggaagaug g                                                            11


<210> 14094
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14094
aaggaagaug                                                              10


<210> 14095
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14095
aaggaagau                                                                9


<210> 14096
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14096
aaggaaga                                                                 8


<210> 14097
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14097
aggaagaugg cauuucuag                                                    19


<210> 14098
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14098
aggaagaugg cauuucua                                                     18


<210> 14099
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14099
aggaagaugg cauuucu                                                      17


<210> 14100
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14100
aggaagaugg cauuuc                                                       16


<210> 14101
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14101
aggaagaugg cauuu                                                        15


<210> 14102
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14102
aggaagaugg cauu                                                         14


<210> 14103
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14103
aggaagaugg cau                                                          13


<210> 14104
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14104
aggaagaugg ca                                                           12


<210> 14105
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14105
aggaagaugg                                                              10


<210> 14106
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14106
aggaagaug                                                                9


<210> 14107
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14107
aggaagau                                                                 8


<210> 14108
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14108
ggaagauggc auuucuag                                                     18


<210> 14109
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14109
ggaagauggc auuucua                                                      17


<210> 14110
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14110
ggaagauggc auuucu                                                       16


<210> 14111
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14111
ggaagauggc auuuc                                                        15


<210> 14112
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14112
ggaagauggc auuu                                                         14


<210> 14113
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14113
ggaagauggc auu                                                          13


<210> 14114
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14114
ggaagauggc au                                                           12


<210> 14115
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14115
ggaagauggc a                                                            11


<210> 14116
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14116
ggaagauggc                                                              10


<210> 14117
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14117
ggaagaug                                                                 8


<210> 14118
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14118
gaagauggca uuucuag                                                      17


<210> 14119
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14119
gaagauggca uuucua                                                       16


<210> 14120
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14120
gaagauggca uuuc                                                         14


<210> 14121
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14121
gaagauggca uuu                                                          13


<210> 14122
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14122
gaagauggca uu                                                           12


<210> 14123
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14123
gaagauggca u                                                            11


<210> 14124
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14124
gaagauggca                                                              10


<210> 14125
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14125
gaagauggc                                                                9


<210> 14126
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14126
gaagaugg                                                                 8


<210> 14127
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14127
aagauggcau uucuag                                                       16


<210> 14128
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14128
aagauggcau uucua                                                        15


<210> 14129
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14129
aagauggcau uucu                                                         14


<210> 14130
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14130
aagauggcau uuc                                                          13


<210> 14131
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14131
aagauggcau uu                                                           12


<210> 14132
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14132
aagauggcau u                                                            11


<210> 14133
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14133
aagauggcau                                                              10


<210> 14134
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14134
aagauggca                                                                9


<210> 14135
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14135
aagauggc                                                                 8


<210> 14136
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14136
agauggcauu ucuag                                                        15


<210> 14137
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14137
agauggcauu ucua                                                         14


<210> 14138
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14138
agauggcauu ucu                                                          13


<210> 14139
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14139
agauggcauu uc                                                           12


<210> 14140
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14140
agauggcauu u                                                            11


<210> 14141
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14141
agauggcauu                                                              10


<210> 14142
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14142
agauggcau                                                                9


<210> 14143
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14143
agauggca                                                                 8


<210> 14144
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14144
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 14145
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14145
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 14146
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14146
cuccaacauc aaggaagaug gcauuucu                                          28


<210> 14147
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14147
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 14148
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14148
cuccaacauc aaggaagaug gcauuu                                            26


<210> 14149
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14149
cuccaacauc aaggaagaug gcauu                                             25


<210> 14150
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14150
cuccaacauc aaggaagaug gcau                                              24


<210> 14151
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14151
cuccaacauc aaggaagaug gca                                               23


<210> 14152
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14152
cuccaacauc aaggaagaug gc                                                22


<210> 14153
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14153
cuccaacauc aaggaagaug g                                                 21


<210> 14154
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14154
cuccaacauc aaggaagaug                                                   20


<210> 14155
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14155
cuccaacauc aaggaagau                                                    19


<210> 14156
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14156
cuccaacauc aaggaaga                                                     18


<210> 14157
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14157
cuccaacauc aaggaag                                                      17


<210> 14158
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14158
tccaacauca aggaagaugg cauuucuag                                         29


<210> 14159
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14159
tccaacauca aggaagaugg cauuucua                                          28


<210> 14160
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14160
tccaacauca aggaagaugg cauuucu                                           27


<210> 14161
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14161
tccaacauca aggaagaugg cauuuc                                            26


<210> 14162
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14162
tccaacauca aggaagaugg cauuu                                             25


<210> 14163
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14163
tccaacauca aggaagaugg cauu                                              24


<210> 14164
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14164
tccaacauca aggaagaugg cau                                               23


<210> 14165
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14165
tccaacauca aggaagaugg ca                                                22


<210> 14166
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14166
tccaacauca aggaagaugg c                                                 21


<210> 14167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14167
tccaacauca aggaagaugg                                                   20


<210> 14168
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14168
tccaacauca aggaagaug                                                    19


<210> 14169
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14169
tccaacauca aggaagau                                                     18


<210> 14170
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14170
tccaacauca aggaaga                                                      17


<210> 14171
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14171
tccaacauca aggaag                                                       16


<210> 14172
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14172
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 14173
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14173
ccaacaucaa ggaagauggc auuucua                                           27


<210> 14174
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14174
ccaacaucaa ggaagauggc auuucu                                            26


<210> 14175
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14175
ccaacaucaa ggaagauggc auuuc                                             25


<210> 14176
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14176
ccaacaucaa ggaagauggc auuu                                              24


<210> 14177
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14177
ccaacaucaa ggaagauggc auu                                               23


<210> 14178
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14178
ccaacaucaa ggaagauggc au                                                22


<210> 14179
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14179
ccaacaucaa ggaagauggc a                                                 21


<210> 14180
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14180
ccaacaucaa ggaagauggc                                                   20


<210> 14181
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14181
ccaacaucaa ggaagaugg                                                    19


<210> 14182
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14182
ccaacaucaa ggaagaug                                                     18


<210> 14183
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14183
ccaacaucaa ggaagau                                                      17


<210> 14184
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14184
ccaacaucaa ggaaga                                                       16


<210> 14185
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14185
ccaacaucaa ggaag                                                        15


<210> 14186
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14186
caacaucaag gaagauggca uuucuag                                           27


<210> 14187
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14187
caacaucaag gaagauggca uuucua                                            26


<210> 14188
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14188
caacaucaag gaagauggca uuucu                                             25


<210> 14189
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14189
caacaucaag gaagauggca uuuc                                              24


<210> 14190
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14190
caacaucaag gaagauggca uuu                                               23


<210> 14191
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14191
caacaucaag gaagauggca uu                                                22


<210> 14192
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14192
caacaucaag gaagauggca u                                                 21


<210> 14193
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14193
caacaucaag gaagauggca                                                   20


<210> 14194
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14194
caacaucaag gaagauggc                                                    19


<210> 14195
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14195
caacaucaag gaagaugg                                                     18


<210> 14196
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14196
caacaucaag gaagaug                                                      17


<210> 14197
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14197
caacaucaag gaagau                                                       16


<210> 14198
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14198
caacaucaag gaaga                                                        15


<210> 14199
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14199
caacaucaag gaag                                                         14


<210> 14200
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14200
aacaucaagg aagauggcau uucuag                                            26


<210> 14201
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14201
aacaucaagg aagauggcau uucua                                             25


<210> 14202
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14202
aacaucaagg aagauggcau uucu                                              24


<210> 14203
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14203
aacaucaagg aagauggcau uuc                                               23


<210> 14204
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14204
aacaucaagg aagauggcau uu                                                22


<210> 14205
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14205
aacaucaagg aagauggcau u                                                 21


<210> 14206
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14206
aacaucaagg aagauggcau                                                   20


<210> 14207
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14207
aacaucaagg aagauggca                                                    19


<210> 14208
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14208
aacaucaagg aagauggc                                                     18


<210> 14209
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14209
aacaucaagg aagaugg                                                      17


<210> 14210
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14210
aacaucaagg aagaug                                                       16


<210> 14211
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14211
aacaucaagg aagau                                                        15


<210> 14212
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14212
aacaucaagg aaga                                                         14


<210> 14213
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14213
aacaucaagg aag                                                          13


<210> 14214
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14214
acaucaagga agauggcauu ucuag                                             25


<210> 14215
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14215
acaucaagga agauggcauu ucua                                              24


<210> 14216
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14216
acaucaagga agauggcauu ucu                                               23


<210> 14217
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14217
acaucaagga agauggcauu uc                                                22


<210> 14218
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14218
acaucaagga agauggcauu u                                                 21


<210> 14219
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14219
acaucaagga agauggcauu                                                   20


<210> 14220
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14220
acaucaagga agauggcau                                                    19


<210> 14221
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14221
acaucaagga agauggca                                                     18


<210> 14222
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14222
acaucaagga agauggc                                                      17


<210> 14223
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14223
acaucaagga agaugg                                                       16


<210> 14224
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14224
acaucaagga agaug                                                        15


<210> 14225
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14225
acaucaagga agau                                                         14


<210> 14226
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14226
acaucaagga aga                                                          13


<210> 14227
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14227
acaucaagga ag                                                           12


<210> 14228
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14228
caucaaggaa gauggcauuu cuag                                              24


<210> 14229
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14229
caucaaggaa gauggcauuu cua                                               23


<210> 14230
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14230
caucaaggaa gauggcauuu cu                                                22


<210> 14231
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14231
caucaaggaa gauggcauuu c                                                 21


<210> 14232
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14232
caucaaggaa gauggcauuu                                                   20


<210> 14233
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14233
caucaaggaa gauggcauu                                                    19


<210> 14234
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14234
caucaaggaa gauggcau                                                     18


<210> 14235
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14235
caucaaggaa gauggca                                                      17


<210> 14236
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14236
caucaaggaa gauggc                                                       16


<210> 14237
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14237
caucaaggaa gaugg                                                        15


<210> 14238
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14238
caucaaggaa gaug                                                         14


<210> 14239
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14239
caucaaggaa gau                                                          13


<210> 14240
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14240
caucaaggaa ga                                                           12


<210> 14241
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14241
caucaaggaa g                                                            11


<210> 14242
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14242
aucaaggaag auggcauuuc uag                                               23


<210> 14243
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14243
aucaaggaag auggcauuuc ua                                                22


<210> 14244
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14244
aucaaggaag auggcauuuc u                                                 21


<210> 14245
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14245
aucaaggaag auggcauuuc                                                   20


<210> 14246
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14246
aucaaggaag auggcauuu                                                    19


<210> 14247
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14247
aucaaggaag auggcauu                                                     18


<210> 14248
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14248
aucaaggaag auggcau                                                      17


<210> 14249
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14249
aucaaggaag auggca                                                       16


<210> 14250
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14250
aucaaggaag auggc                                                        15


<210> 14251
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14251
aucaaggaag augg                                                         14


<210> 14252
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14252
aucaaggaag aug                                                          13


<210> 14253
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14253
aucaaggaag au                                                           12


<210> 14254
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14254
aucaaggaag a                                                            11


<210> 14255
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14255
aucaaggaag                                                              10


<210> 14256
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14256
ccagagcagg uaccuccaac auc                                               23


<210> 14257
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14257
ccagagcagg uaccucca                                                     18


<210> 14258
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14258
ccucugugau uuuauaacuu gau                                               23


<210> 14259
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14259
tcacccacca ucacccu                                                      17


<210> 14260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14260
tgauauccuc aaggucaccc                                                   20


<210> 14261
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14261
cugcuugaug aucaucucgu ug                                                22


<210> 14262
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14262
cugcuugaug aucaucuc                                                     18


<210> 14263
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14263
guuuccuuag uaaccacag                                                    19


<210> 14264
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 14264
guuuccuuag uaaccac                                                      17


<210> 14265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14265
ucaaggaaga uggcauuuct                                                   20


<210> 14266
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14266
ucaaggaaga uggcauuucu ag                                                22


<210> 14267
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14267
gguaaguucu guccaagc                                                     18


<210> 14268
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14268
guaaguucug uccaagcc                                                     18


<210> 14269
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14269
agucgguaag uucugucc                                                     18


<210> 14270
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14270
cuguccaagc ccgguuga                                                     18


<210> 14271
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14271
uaaguucugu ccaag                                                        15


<210> 14272
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14272
uucuguccaa gcccgguuga                                                   20


<210> 14273
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14273
uucuguccaa gcccgguug                                                    19


<210> 14274
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14274
uucuguccaa gcccggut                                                     18


<210> 14275
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14275
uucuguccaa gcccggt                                                      17


<210> 14276
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14276
uucuguccaa gcccgg                                                       16


<210> 14277
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14277
uucuguccaa gcccg                                                        15


<210> 14278
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14278
uucuguccaa gccc                                                         14


<210> 14279
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14279
uucuguccaa gcc                                                          13


<210> 14280
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14280
uucuguccaa gc                                                           12


<210> 14281
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14281
uucuguccaa g                                                            11


<210> 14282
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14282
uucuguccaa                                                              10


<210> 14283
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14283
uucugucca                                                                9


<210> 14284
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 14284
uucugucc                                                                 8


<210> 14285
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14285
ucuguccaag cccgguuga                                                    19


<210> 14286
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14286
ucuguccaag cccgguug                                                     18


<210> 14287
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14287
ucuguccaag cccggut                                                      17


<210> 14288
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14288
ucuguccaag cccggt                                                       16


<210> 14289
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14289
ucuguccaag cccgg                                                        15


<210> 14290
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14290
ucuguccaag cccg                                                         14


<210> 14291
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14291
ucuguccaag ccc                                                          13


<210> 14292
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14292
ucuguccaag cc                                                           12


<210> 14293
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 14293
ucuguccaag c                                                            11


<210> 14294
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14294
ucuguccaag                                                              10


<210> 14295
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14295
ucuguccaa                                                                9


<210> 14296
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14296
ucugucca                                                                 8


<210> 14297
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14297
cuguccaagc ccgguug                                                      17


<210> 14298
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14298
cuguccaagc ccggut                                                       16


<210> 14299
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14299
cuguccaagc ccggt                                                        15


<210> 14300
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14300
cuguccaagc ccgg                                                         14


<210> 14301
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14301
cuguccaagc ccg                                                          13


<210> 14302
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14302
cuguccaagc cc                                                           12


<210> 14303
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 14303
cuguccaagc c                                                            11


<210> 14304
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 14304
cuguccaagc                                                              10


<210> 14305
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14305
cuguccaag                                                                9


<210> 14306
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14306
cuguccaa                                                                 8


<210> 14307
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14307
guucugucca agcccgguug                                                   20


<210> 14308
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14308
guucugucca agcccggut                                                    19


<210> 14309
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14309
guucugucca agcccggt                                                     18


<210> 14310
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14310
guucugucca agcccgg                                                      17


<210> 14311
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14311
guucugucca agcccg                                                       16


<210> 14312
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14312
guucugucca agccc                                                        15


<210> 14313
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14313
guucugucca agcc                                                         14


<210> 14314
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14314
guucugucca agc                                                          13


<210> 14315
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14315
guucugucca ag                                                           12


<210> 14316
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14316
guucugucca a                                                            11


<210> 14317
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14317
guucugucca                                                              10


<210> 14318
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 14318
guucugucc                                                                9


<210> 14319
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 14319
guucuguc                                                                 8


<210> 14320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14320
aguucugucc aagcccggut                                                   20


<210> 14321
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14321
aguucugucc aagcccggt                                                    19


<210> 14322
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14322
aguucugucc aagcccgg                                                     18


<210> 14323
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14323
aguucugucc aagcccg                                                      17


<210> 14324
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14324
aguucugucc aagccc                                                       16


<210> 14325
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14325
aguucugucc aagcc                                                        15


<210> 14326
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14326
aguucugucc aagc                                                         14


<210> 14327
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14327
aguucugucc aag                                                          13


<210> 14328
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14328
aguucugucc aa                                                           12


<210> 14329
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14329
aguucugucc a                                                            11


<210> 14330
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 14330
aguucugucc                                                              10


<210> 14331
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 14331
aguucuguc                                                                9


<210> 14332
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14332
aguucugt                                                                 8


<210> 14333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14333
aaguucuguc caagcccggt                                                   20


<210> 14334
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14334
aaguucuguc caagcccgg                                                    19


<210> 14335
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14335
aaguucuguc caagcccg                                                     18


<210> 14336
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14336
aaguucuguc caagccc                                                      17


<210> 14337
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14337
aaguucuguc caagcc                                                       16


<210> 14338
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14338
aaguucuguc caagc                                                        15


<210> 14339
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14339
aaguucuguc caag                                                         14


<210> 14340
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14340
aaguucuguc caa                                                          13


<210> 14341
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14341
aaguucuguc ca                                                           12


<210> 14342
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 14342
aaguucuguc c                                                            11


<210> 14343
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 14343
aaguucuguc                                                              10


<210> 14344
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14344
aaguucugt                                                                9


<210> 14345
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14345
aaguucug                                                                 8


<210> 14346
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14346
uaaguucugu ccaagcccgg                                                   20


<210> 14347
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14347
uaaguucugu ccaagcccg                                                    19


<210> 14348
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14348
uaaguucugu ccaagccc                                                     18


<210> 14349
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14349
uaaguucugu ccaagcc                                                      17


<210> 14350
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14350
uaaguucugu ccaagc                                                       16


<210> 14351
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14351
uaaguucugu ccaa                                                         14


<210> 14352
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14352
uaaguucugu cca                                                          13


<210> 14353
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14353
uaaguucugu cc                                                           12


<210> 14354
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 14354
uaaguucugu c                                                            11


<210> 14355
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14355
uaaguucugt                                                              10


<210> 14356
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14356
uaaguucug                                                                9


<210> 14357
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14357
uaaguuct                                                                 8


<210> 14358
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14358
guaaguucug uccaagcccg                                                   20


<210> 14359
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14359
guaaguucug uccaagccc                                                    19


<210> 14360
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14360
guaaguucug uccaagc                                                      17


<210> 14361
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14361
guaaguucug uccaag                                                       16


<210> 14362
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14362
guaaguucug uccaa                                                        15


<210> 14363
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14363
guaaguucug ucca                                                         14


<210> 14364
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14364
guaaguucug ucc                                                          13


<210> 14365
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14365
guaaguucug uc                                                           12


<210> 14366
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14366
guaaguucug t                                                            11


<210> 14367
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14367
guaaguucug                                                              10


<210> 14368
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14368
guaaguuct                                                                9


<210> 14369
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 14369
guaaguuc                                                                 8


<210> 14370
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14370
gguaaguucu guccaagccc                                                   20


<210> 14371
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14371
gguaaguucu guccaagcc                                                    19


<210> 14372
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14372
gguaaguucu guccaag                                                      17


<210> 14373
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14373
gguaaguucu guccaa                                                       16


<210> 14374
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14374
gguaaguucu gucca                                                        15


<210> 14375
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14375
gguaaguucu gucc                                                         14


<210> 14376
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14376
gguaaguucu guc                                                          13


<210> 14377
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14377
gguaaguucu gt                                                           12


<210> 14378
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14378
gguaaguucu g                                                            11


<210> 14379
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14379
gguaaguuct                                                              10


<210> 14380
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 14380
gguaaguuc                                                                9


<210> 14381
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14381
gguaagut                                                                 8


<210> 14382
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14382
cgguaaguuc uguccaagcc                                                   20


<210> 14383
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14383
cgguaaguuc uguccaagc                                                    19


<210> 14384
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14384
cgguaaguuc uguccaag                                                     18


<210> 14385
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14385
cgguaaguuc uguccaa                                                      17


<210> 14386
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14386
cgguaaguuc ugucca                                                       16


<210> 14387
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14387
cgguaaguuc ugucc                                                        15


<210> 14388
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14388
cgguaaguuc uguc                                                         14


<210> 14389
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14389
cgguaaguuc ugt                                                          13


<210> 14390
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14390
cgguaaguuc ug                                                           12


<210> 14391
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14391
cgguaaguuc t                                                            11


<210> 14392
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 14392
cgguaaguuc                                                              10


<210> 14393
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14393
cgguaagut                                                                9


<210> 14394
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14394
cgguaagt                                                                 8


<210> 14395
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14395
ucgguaaguu cuguccaagc                                                   20


<210> 14396
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14396
ucgguaaguu cuguccaag                                                    19


<210> 14397
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14397
ucgguaaguu cuguccaa                                                     18


<210> 14398
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14398
ucgguaaguu cugucca                                                      17


<210> 14399
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14399
ucgguaaguu cugucc                                                       16


<210> 14400
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14400
ucgguaaguu cuguc                                                        15


<210> 14401
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14401
ucgguaaguu cugt                                                         14


<210> 14402
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14402
ucgguaaguu cug                                                          13


<210> 14403
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14403
ucgguaaguu ct                                                           12


<210> 14404
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 14404
ucgguaaguu c                                                            11


<210> 14405
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14405
ucgguaagut                                                              10


<210> 14406
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14406
ucgguaagt                                                                9


<210> 14407
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14407
gucgguaagu ucuguccaag                                                   20


<210> 14408
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14408
gucgguaagu ucuguccaa                                                    19


<210> 14409
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14409
gucgguaagu ucugucca                                                     18


<210> 14410
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14410
gucgguaagu ucugucc                                                      17


<210> 14411
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14411
gucgguaagu ucuguc                                                       16


<210> 14412
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14412
gucgguaagu ucugt                                                        15


<210> 14413
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14413
gucgguaagu ucug                                                         14


<210> 14414
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14414
gucgguaagu uct                                                          13


<210> 14415
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14415
gucgguaagu uc                                                           12


<210> 14416
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14416
gucgguaagu t                                                            11


<210> 14417
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14417
gucgguaagt                                                              10


<210> 14418
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14418
agucgguaag uucuguccaa                                                   20


<210> 14419
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14419
agucgguaag uucugucca                                                    19


<210> 14420
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14420
agucgguaag uucuguc                                                      17


<210> 14421
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14421
agucgguaag uucugt                                                       16


<210> 14422
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14422
agucgguaag uucug                                                        15


<210> 14423
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14423
agucgguaag uuct                                                         14


<210> 14424
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14424
agucgguaag uuc                                                          13


<210> 14425
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14425
agucgguaag ut                                                           12


<210> 14426
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14426
agucgguaag t                                                            11


<210> 14427
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14427
cagucgguaa guucugucca                                                   20


<210> 14428
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14428
cagucgguaa guucugucc                                                    19


<210> 14429
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14429
cagucgguaa guucuguc                                                     18


<210> 14430
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14430
cagucgguaa guucugt                                                      17


<210> 14431
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14431
cagucgguaa guucug                                                       16


<210> 14432
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14432
cagucgguaa guuct                                                        15


<210> 14433
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14433
cagucgguaa guuc                                                         14


<210> 14434
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14434
cagucgguaa gut                                                          13


<210> 14435
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14435
cagucgguaa gt                                                           12


<210> 14436
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14436
ccagucggua aguucugucc                                                   20


<210> 14437
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14437
ccagucggua aguucuguc                                                    19


<210> 14438
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14438
ccagucggua aguucugt                                                     18


<210> 14439
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14439
ccagucggua aguucug                                                      17


<210> 14440
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14440
ccagucggua aguuct                                                       16


<210> 14441
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14441
ccagucggua aguuc                                                        15


<210> 14442
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14442
ccagucggua agut                                                         14


<210> 14443
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14443
ccagucggua agt                                                          13


<210> 14444
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14444
gccagucggu aaguucuguc                                                   20


<210> 14445
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14445
gccagucggu aaguucugt                                                    19


<210> 14446
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14446
gccagucggu aaguucug                                                     18


<210> 14447
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14447
gccagucggu aaguuct                                                      17


<210> 14448
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14448
gccagucggu aaguuc                                                       16


<210> 14449
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14449
gccagucggu aagut                                                        15


<210> 14450
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14450
gccagucggu aagt                                                         14


<210> 14451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14451
ucaaggaaga uggcauuuct                                                   20


<210> 14452
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14452
ucaaggaaga uggcauuucu ag                                                22


<210> 14453
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14453
ucaaggaaga uggcat                                                       16


<210> 14454
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14454
gaagauggca uuuct                                                        15


<210> 14455
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14455
ucaaggaaga uggcauuucu a                                                 21


<210> 14456
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14456
ucaaggaaga uggcauuuc                                                    19


<210> 14457
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14457
ucaaggaaga uggcauut                                                     18


<210> 14458
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14458
ucaaggaaga uggcaut                                                      17


<210> 14459
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14459
ucaaggaaga uggca                                                        15


<210> 14460
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14460
ucaaggaaga uggc                                                         14


<210> 14461
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14461
ucaaggaaga ugg                                                          13


<210> 14462
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14462
ucaaggaaga ug                                                           12


<210> 14463
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14463
ucaaggaaga t                                                            11


<210> 14464
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14464
ucaaggaaga                                                              10


<210> 14465
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14465
ucaaggaag                                                                9


<210> 14466
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14466
caaggaagau ggcauuucua g                                                 21


<210> 14467
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14467
caaggaagau ggcauuucua                                                   20


<210> 14468
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14468
caaggaagau ggcauuuct                                                    19


<210> 14469
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14469
caaggaagau ggcauuuc                                                     18


<210> 14470
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14470
caaggaagau ggcauut                                                      17


<210> 14471
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14471
caaggaagau ggcaut                                                       16


<210> 14472
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14472
caaggaagau ggcat                                                        15


<210> 14473
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14473
caaggaagau ggca                                                         14


<210> 14474
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14474
caaggaagau ggc                                                          13


<210> 14475
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14475
caaggaagau gg                                                           12


<210> 14476
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14476
caaggaagau g                                                            11


<210> 14477
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14477
caaggaagat                                                              10


<210> 14478
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14478
caaggaaga                                                                9


<210> 14479
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14479
caaggaag                                                                 8


<210> 14480
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14480
aaggaagaug gcauuucuag                                                   20


<210> 14481
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14481
aaggaagaug gcauuucua                                                    19


<210> 14482
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14482
aaggaagaug gcauuuct                                                     18


<210> 14483
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14483
aaggaagaug gcauuuc                                                      17


<210> 14484
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14484
aaggaagaug gcauut                                                       16


<210> 14485
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14485
aaggaagaug gcaut                                                        15


<210> 14486
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14486
aaggaagaug gcat                                                         14


<210> 14487
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14487
aaggaagaug gca                                                          13


<210> 14488
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14488
aaggaagaug gc                                                           12


<210> 14489
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14489
aaggaagaug g                                                            11


<210> 14490
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14490
aaggaagaug                                                              10


<210> 14491
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14491
aaggaagat                                                                9


<210> 14492
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14492
aaggaaga                                                                 8


<210> 14493
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14493
aggaagaugg cauuucuag                                                    19


<210> 14494
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14494
aggaagaugg cauuucua                                                     18


<210> 14495
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14495
aggaagaugg cauuuct                                                      17


<210> 14496
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14496
aggaagaugg cauuuc                                                       16


<210> 14497
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14497
aggaagaugg cauut                                                        15


<210> 14498
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14498
aggaagaugg caut                                                         14


<210> 14499
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14499
aggaagaugg cat                                                          13


<210> 14500
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14500
aggaagaugg ca                                                           12


<210> 14501
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14501
aggaagaugg                                                              10


<210> 14502
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14502
aggaagaug                                                                9


<210> 14503
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14503
aggaagat                                                                 8


<210> 14504
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14504
ggaagauggc auuucuag                                                     18


<210> 14505
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14505
ggaagauggc auuucua                                                      17


<210> 14506
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14506
ggaagauggc auuuct                                                       16


<210> 14507
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14507
ggaagauggc auuuc                                                        15


<210> 14508
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14508
ggaagauggc auut                                                         14


<210> 14509
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14509
ggaagauggc aut                                                          13


<210> 14510
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14510
ggaagauggc at                                                           12


<210> 14511
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14511
ggaagauggc a                                                            11


<210> 14512
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 14512
ggaagauggc                                                              10


<210> 14513
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14513
ggaagaug                                                                 8


<210> 14514
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14514
gaagauggca uuucuag                                                      17


<210> 14515
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14515
gaagauggca uuucua                                                       16


<210> 14516
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14516
gaagauggca uuuc                                                         14


<210> 14517
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14517
gaagauggca uut                                                          13


<210> 14518
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14518
gaagauggca ut                                                           12


<210> 14519
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14519
gaagauggca t                                                            11


<210> 14520
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14520
gaagauggca                                                              10


<210> 14521
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 14521
gaagauggc                                                                9


<210> 14522
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14522
gaagaugg                                                                 8


<210> 14523
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14523
aagauggcau uucuag                                                       16


<210> 14524
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14524
aagauggcau uucua                                                        15


<210> 14525
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14525
aagauggcau uuct                                                         14


<210> 14526
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14526
aagauggcau uuc                                                          13


<210> 14527
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14527
aagauggcau ut                                                           12


<210> 14528
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14528
aagauggcau t                                                            11


<210> 14529
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14529
aagauggcat                                                              10


<210> 14530
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14530
aagauggca                                                                9


<210> 14531
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 14531
aagauggc                                                                 8


<210> 14532
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14532
agauggcauu ucuag                                                        15


<210> 14533
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14533
agauggcauu ucua                                                         14


<210> 14534
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14534
agauggcauu uct                                                          13


<210> 14535
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14535
agauggcauu uc                                                           12


<210> 14536
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14536
agauggcauu t                                                            11


<210> 14537
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14537
agauggcaut                                                              10


<210> 14538
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14538
agauggcat                                                                9


<210> 14539
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14539
agauggca                                                                 8


<210> 14540
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 14540
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 14541
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 14541
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 14542
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 14542
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 14543
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<400> 14543
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 14544
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 14544
cuccaacauc aaggaagaug gcauut                                            26


<210> 14545
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 14545
cuccaacauc aaggaagaug gcaut                                             25


<210> 14546
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 14546
cuccaacauc aaggaagaug gcat                                              24


<210> 14547
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14547
cuccaacauc aaggaagaug gca                                               23


<210> 14548
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 14548
cuccaacauc aaggaagaug gc                                                22


<210> 14549
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14549
cuccaacauc aaggaagaug g                                                 21


<210> 14550
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14550
cuccaacauc aaggaagaug                                                   20


<210> 14551
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14551
cuccaacauc aaggaagat                                                    19


<210> 14552
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14552
cuccaacauc aaggaaga                                                     18


<210> 14553
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14553
cuccaacauc aaggaag                                                      17


<210> 14554
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 14554
uccaacauca aggaagaugg cauuucuag                                         29


<210> 14555
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 14555
uccaacauca aggaagaugg cauuucua                                          28


<210> 14556
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 14556
uccaacauca aggaagaugg cauuuct                                           27


<210> 14557
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<400> 14557
uccaacauca aggaagaugg cauuuc                                            26


<210> 14558
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 14558
uccaacauca aggaagaugg cauut                                             25


<210> 14559
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 14559
uccaacauca aggaagaugg caut                                              24


<210> 14560
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14560
uccaacauca aggaagaugg cat                                               23


<210> 14561
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14561
uccaacauca aggaagaugg ca                                                22


<210> 14562
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 14562
uccaacauca aggaagaugg c                                                 21


<210> 14563
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14563
uccaacauca aggaagaugg                                                   20


<210> 14564
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14564
uccaacauca aggaagaug                                                    19


<210> 14565
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14565
uccaacauca aggaagat                                                     18


<210> 14566
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14566
uccaacauca aggaaga                                                      17


<210> 14567
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14567
uccaacauca aggaag                                                       16


<210> 14568
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 14568
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 14569
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 14569
ccaacaucaa ggaagauggc auuucua                                           27


<210> 14570
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 14570
ccaacaucaa ggaagauggc auuuct                                            26


<210> 14571
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<400> 14571
ccaacaucaa ggaagauggc auuuc                                             25


<210> 14572
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 14572
ccaacaucaa ggaagauggc auut                                              24


<210> 14573
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14573
ccaacaucaa ggaagauggc aut                                               23


<210> 14574
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14574
ccaacaucaa ggaagauggc at                                                22


<210> 14575
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14575
ccaacaucaa ggaagauggc a                                                 21


<210> 14576
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14576
ccaacaucaa ggaagauggc                                                   20


<210> 14577
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14577
ccaacaucaa ggaagaugg                                                    19


<210> 14578
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14578
ccaacaucaa ggaagaug                                                     18


<210> 14579
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14579
ccaacaucaa ggaagat                                                      17


<210> 14580
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14580
ccaacaucaa ggaaga                                                       16


<210> 14581
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14581
ccaacaucaa ggaag                                                        15


<210> 14582
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 14582
caacaucaag gaagauggca uuucuag                                           27


<210> 14583
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 14583
caacaucaag gaagauggca uuucua                                            26


<210> 14584
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 14584
caacaucaag gaagauggca uuuct                                             25


<210> 14585
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<400> 14585
caacaucaag gaagauggca uuuc                                              24


<210> 14586
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14586
caacaucaag gaagauggca uut                                               23


<210> 14587
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14587
caacaucaag gaagauggca ut                                                22


<210> 14588
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14588
caacaucaag gaagauggca t                                                 21


<210> 14589
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14589
caacaucaag gaagauggca                                                   20


<210> 14590
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14590
caacaucaag gaagauggc                                                    19


<210> 14591
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14591
caacaucaag gaagaugg                                                     18


<210> 14592
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14592
caacaucaag gaagaug                                                      17


<210> 14593
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14593
caacaucaag gaagat                                                       16


<210> 14594
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14594
caacaucaag gaaga                                                        15


<210> 14595
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14595
caacaucaag gaag                                                         14


<210> 14596
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 14596
aacaucaagg aagauggcau uucuag                                            26


<210> 14597
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 14597
aacaucaagg aagauggcau uucua                                             25


<210> 14598
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 14598
aacaucaagg aagauggcau uuct                                              24


<210> 14599
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 14599
aacaucaagg aagauggcau uuc                                               23


<210> 14600
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14600
aacaucaagg aagauggcau ut                                                22


<210> 14601
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14601
aacaucaagg aagauggcau t                                                 21


<210> 14602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14602
aacaucaagg aagauggcat                                                   20


<210> 14603
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14603
aacaucaagg aagauggca                                                    19


<210> 14604
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14604
aacaucaagg aagauggc                                                     18


<210> 14605
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14605
aacaucaagg aagaugg                                                      17


<210> 14606
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14606
aacaucaagg aagaug                                                       16


<210> 14607
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14607
aacaucaagg aagat                                                        15


<210> 14608
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14608
aacaucaagg aaga                                                         14


<210> 14609
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14609
aacaucaagg aag                                                          13


<210> 14610
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 14610
acaucaagga agauggcauu ucuag                                             25


<210> 14611
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 14611
acaucaagga agauggcauu ucua                                              24


<210> 14612
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14612
acaucaagga agauggcauu uct                                               23


<210> 14613
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 14613
acaucaagga agauggcauu uc                                                22


<210> 14614
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14614
acaucaagga agauggcauu t                                                 21


<210> 14615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14615
acaucaagga agauggcaut                                                   20


<210> 14616
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14616
acaucaagga agauggcat                                                    19


<210> 14617
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14617
acaucaagga agauggca                                                     18


<210> 14618
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14618
acaucaagga agauggc                                                      17


<210> 14619
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14619
acaucaagga agaugg                                                       16


<210> 14620
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14620
acaucaagga agaug                                                        15


<210> 14621
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14621
acaucaagga agat                                                         14


<210> 14622
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14622
acaucaagga aga                                                          13


<210> 14623
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14623
acaucaagga ag                                                           12


<210> 14624
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 14624
caucaaggaa gauggcauuu cuag                                              24


<210> 14625
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14625
caucaaggaa gauggcauuu cua                                               23


<210> 14626
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14626
caucaaggaa gauggcauuu ct                                                22


<210> 14627
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 14627
caucaaggaa gauggcauuu c                                                 21


<210> 14628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14628
caucaaggaa gauggcauut                                                   20


<210> 14629
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14629
caucaaggaa gauggcaut                                                    19


<210> 14630
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14630
caucaaggaa gauggcat                                                     18


<210> 14631
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14631
caucaaggaa gauggca                                                      17


<210> 14632
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14632
caucaaggaa gauggc                                                       16


<210> 14633
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14633
caucaaggaa gaugg                                                        15


<210> 14634
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14634
caucaaggaa gaug                                                         14


<210> 14635
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14635
caucaaggaa gat                                                          13


<210> 14636
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14636
caucaaggaa ga                                                           12


<210> 14637
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14637
caucaaggaa g                                                            11


<210> 14638
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14638
aucaaggaag auggcauuuc uag                                               23


<210> 14639
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14639
aucaaggaag auggcauuuc ua                                                22


<210> 14640
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14640
aucaaggaag auggcauuuc t                                                 21


<210> 14641
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14641
aucaaggaag auggcauuuc                                                   20


<210> 14642
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14642
aucaaggaag auggcauut                                                    19


<210> 14643
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14643
aucaaggaag auggcaut                                                     18


<210> 14644
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14644
aucaaggaag auggcat                                                      17


<210> 14645
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14645
aucaaggaag auggca                                                       16


<210> 14646
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14646
aucaaggaag auggc                                                        15


<210> 14647
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14647
aucaaggaag augg                                                         14


<210> 14648
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14648
aucaaggaag aug                                                          13


<210> 14649
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14649
aucaaggaag at                                                           12


<210> 14650
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14650
aucaaggaag a                                                            11


<210> 14651
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14651
aucaaggaag                                                              10


<210> 14652
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 14652
ccagagcagg uaccuccaac auc                                               23


<210> 14653
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14653
ccagagcagg uaccucca                                                     18


<210> 14654
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14654
ccucugugau uuuauaacuu gat                                               23


<210> 14655
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14655
ucacccacca ucaccct                                                      17


<210> 14656
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14656
ugauauccuc aaggucaccc                                                   20


<210> 14657
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14657
cugcuugaug aucaucucgu ug                                                22


<210> 14658
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14658
cugcuugaug aucaucuc                                                     18


<210> 14659
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14659
guuuccuuag uaaccacag                                                    19


<210> 14660
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14660
guuuccuuag uaaccac                                                      17


<210> 14661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14661
ucaaggaaga uggcauuuct                                                   20


<210> 14662
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14662
ucaaggaaga uggcauuucu ag                                                22


<210> 14663
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14663
gguaaguucu guccaagc                                                     18


<210> 14664
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14664
guaaguucug uccaagcc                                                     18


<210> 14665
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14665
agucgguaag uucugucc                                                     18


<210> 14666
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14666
cuguccaagc ccgguuga                                                     18


<210> 14667
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14667
uaaguucugu ccaag                                                        15


<210> 14668
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14668
uucuguccaa gcccgguuga                                                   20


<210> 14669
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14669
uucuguccaa gcccgguug                                                    19


<210> 14670
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14670
uucuguccaa gcccggut                                                     18


<210> 14671
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14671
uucuguccaa gcccggt                                                      17


<210> 14672
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14672
uucuguccaa gcccgg                                                       16


<210> 14673
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14673
uucuguccaa gcccg                                                        15


<210> 14674
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14674
uucuguccaa gccc                                                         14


<210> 14675
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14675
uucuguccaa gcc                                                          13


<210> 14676
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14676
uucuguccaa gc                                                           12


<210> 14677
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14677
uucuguccaa g                                                            11


<210> 14678
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14678
uucuguccaa                                                              10


<210> 14679
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14679
uucugucca                                                                9


<210> 14680
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 14680
uucugucc                                                                 8


<210> 14681
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14681
ucuguccaag cccgguuga                                                    19


<210> 14682
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14682
ucuguccaag cccgguug                                                     18


<210> 14683
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14683
ucuguccaag cccggut                                                      17


<210> 14684
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14684
ucuguccaag cccggt                                                       16


<210> 14685
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14685
ucuguccaag cccgg                                                        15


<210> 14686
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14686
ucuguccaag cccg                                                         14


<210> 14687
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14687
ucuguccaag ccc                                                          13


<210> 14688
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14688
ucuguccaag cc                                                           12


<210> 14689
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 14689
ucuguccaag c                                                            11


<210> 14690
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14690
ucuguccaag                                                              10


<210> 14691
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14691
ucuguccaa                                                                9


<210> 14692
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14692
ucugucca                                                                 8


<210> 14693
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14693
cuguccaagc ccgguug                                                      17


<210> 14694
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14694
cuguccaagc ccggut                                                       16


<210> 14695
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14695
cuguccaagc ccggt                                                        15


<210> 14696
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14696
cuguccaagc ccgg                                                         14


<210> 14697
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14697
cuguccaagc ccg                                                          13


<210> 14698
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14698
cuguccaagc cc                                                           12


<210> 14699
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 14699
cuguccaagc c                                                            11


<210> 14700
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 14700
cuguccaagc                                                              10


<210> 14701
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14701
cuguccaag                                                                9


<210> 14702
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14702
cuguccaa                                                                 8


<210> 14703
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14703
guucugucca agcccgguug                                                   20


<210> 14704
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14704
guucugucca agcccggut                                                    19


<210> 14705
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14705
guucugucca agcccggt                                                     18


<210> 14706
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14706
guucugucca agcccgg                                                      17


<210> 14707
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14707
guucugucca agcccg                                                       16


<210> 14708
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14708
guucugucca agccc                                                        15


<210> 14709
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14709
guucugucca agcc                                                         14


<210> 14710
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14710
guucugucca agc                                                          13


<210> 14711
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14711
guucugucca ag                                                           12


<210> 14712
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14712
guucugucca a                                                            11


<210> 14713
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14713
guucugucca                                                              10


<210> 14714
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 14714
guucugucc                                                                9


<210> 14715
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 14715
guucuguc                                                                 8


<210> 14716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14716
aguucugucc aagcccggut                                                   20


<210> 14717
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14717
aguucugucc aagcccggt                                                    19


<210> 14718
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14718
aguucugucc aagcccgg                                                     18


<210> 14719
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14719
aguucugucc aagcccg                                                      17


<210> 14720
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14720
aguucugucc aagccc                                                       16


<210> 14721
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14721
aguucugucc aagcc                                                        15


<210> 14722
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14722
aguucugucc aagc                                                         14


<210> 14723
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14723
aguucugucc aag                                                          13


<210> 14724
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14724
aguucugucc aa                                                           12


<210> 14725
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14725
aguucugucc a                                                            11


<210> 14726
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 14726
aguucugucc                                                              10


<210> 14727
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 14727
aguucuguc                                                                9


<210> 14728
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14728
aguucugt                                                                 8


<210> 14729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14729
aaguucuguc caagcccggt                                                   20


<210> 14730
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14730
aaguucuguc caagcccgg                                                    19


<210> 14731
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14731
aaguucuguc caagcccg                                                     18


<210> 14732
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14732
aaguucuguc caagccc                                                      17


<210> 14733
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14733
aaguucuguc caagcc                                                       16


<210> 14734
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14734
aaguucuguc caagc                                                        15


<210> 14735
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14735
aaguucuguc caag                                                         14


<210> 14736
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14736
aaguucuguc caa                                                          13


<210> 14737
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14737
aaguucuguc ca                                                           12


<210> 14738
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 14738
aaguucuguc c                                                            11


<210> 14739
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 14739
aaguucuguc                                                              10


<210> 14740
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14740
aaguucugt                                                                9


<210> 14741
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14741
aaguucug                                                                 8


<210> 14742
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14742
uaaguucugu ccaagcccgg                                                   20


<210> 14743
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14743
uaaguucugu ccaagcccg                                                    19


<210> 14744
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14744
uaaguucugu ccaagccc                                                     18


<210> 14745
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14745
uaaguucugu ccaagcc                                                      17


<210> 14746
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14746
uaaguucugu ccaagc                                                       16


<210> 14747
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14747
uaaguucugu ccaa                                                         14


<210> 14748
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14748
uaaguucugu cca                                                          13


<210> 14749
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14749
uaaguucugu cc                                                           12


<210> 14750
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 14750
uaaguucugu c                                                            11


<210> 14751
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14751
uaaguucugt                                                              10


<210> 14752
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14752
uaaguucug                                                                9


<210> 14753
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14753
uaaguuct                                                                 8


<210> 14754
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14754
guaaguucug uccaagcccg                                                   20


<210> 14755
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14755
guaaguucug uccaagccc                                                    19


<210> 14756
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14756
guaaguucug uccaagc                                                      17


<210> 14757
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14757
guaaguucug uccaag                                                       16


<210> 14758
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14758
guaaguucug uccaa                                                        15


<210> 14759
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14759
guaaguucug ucca                                                         14


<210> 14760
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14760
guaaguucug ucc                                                          13


<210> 14761
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14761
guaaguucug uc                                                           12


<210> 14762
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14762
guaaguucug t                                                            11


<210> 14763
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14763
guaaguucug                                                              10


<210> 14764
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14764
guaaguuct                                                                9


<210> 14765
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 14765
guaaguuc                                                                 8


<210> 14766
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14766
gguaaguucu guccaagccc                                                   20


<210> 14767
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14767
gguaaguucu guccaagcc                                                    19


<210> 14768
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14768
gguaaguucu guccaag                                                      17


<210> 14769
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14769
gguaaguucu guccaa                                                       16


<210> 14770
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14770
gguaaguucu gucca                                                        15


<210> 14771
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14771
gguaaguucu gucc                                                         14


<210> 14772
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14772
gguaaguucu guc                                                          13


<210> 14773
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14773
gguaaguucu gt                                                           12


<210> 14774
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14774
gguaaguucu g                                                            11


<210> 14775
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14775
gguaaguuct                                                              10


<210> 14776
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 14776
gguaaguuc                                                                9


<210> 14777
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14777
gguaagut                                                                 8


<210> 14778
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14778
cgguaaguuc uguccaagcc                                                   20


<210> 14779
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14779
cgguaaguuc uguccaagc                                                    19


<210> 14780
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14780
cgguaaguuc uguccaag                                                     18


<210> 14781
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14781
cgguaaguuc uguccaa                                                      17


<210> 14782
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14782
cgguaaguuc ugucca                                                       16


<210> 14783
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14783
cgguaaguuc ugucc                                                        15


<210> 14784
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14784
cgguaaguuc uguc                                                         14


<210> 14785
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14785
cgguaaguuc ugt                                                          13


<210> 14786
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14786
cgguaaguuc ug                                                           12


<210> 14787
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14787
cgguaaguuc t                                                            11


<210> 14788
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 14788
cgguaaguuc                                                              10


<210> 14789
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14789
cgguaagut                                                                9


<210> 14790
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14790
cgguaagt                                                                 8


<210> 14791
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14791
ucgguaaguu cuguccaagc                                                   20


<210> 14792
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14792
ucgguaaguu cuguccaag                                                    19


<210> 14793
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14793
ucgguaaguu cuguccaa                                                     18


<210> 14794
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14794
ucgguaaguu cugucca                                                      17


<210> 14795
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14795
ucgguaaguu cugucc                                                       16


<210> 14796
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14796
ucgguaaguu cuguc                                                        15


<210> 14797
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14797
ucgguaaguu cugt                                                         14


<210> 14798
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14798
ucgguaaguu cug                                                          13


<210> 14799
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14799
ucgguaaguu ct                                                           12


<210> 14800
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 14800
ucgguaaguu c                                                            11


<210> 14801
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14801
ucgguaagut                                                              10


<210> 14802
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14802
ucgguaagt                                                                9


<210> 14803
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14803
gucgguaagu ucuguccaag                                                   20


<210> 14804
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14804
gucgguaagu ucuguccaa                                                    19


<210> 14805
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14805
gucgguaagu ucugucca                                                     18


<210> 14806
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14806
gucgguaagu ucugucc                                                      17


<210> 14807
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14807
gucgguaagu ucuguc                                                       16


<210> 14808
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14808
gucgguaagu ucugt                                                        15


<210> 14809
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14809
gucgguaagu ucug                                                         14


<210> 14810
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14810
gucgguaagu uct                                                          13


<210> 14811
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14811
gucgguaagu uc                                                           12


<210> 14812
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14812
gucgguaagu t                                                            11


<210> 14813
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14813
gucgguaagt                                                              10


<210> 14814
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14814
agucgguaag uucuguccaa                                                   20


<210> 14815
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14815
agucgguaag uucugucca                                                    19


<210> 14816
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14816
agucgguaag uucuguc                                                      17


<210> 14817
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14817
agucgguaag uucugt                                                       16


<210> 14818
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14818
agucgguaag uucug                                                        15


<210> 14819
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14819
agucgguaag uuct                                                         14


<210> 14820
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14820
agucgguaag uuc                                                          13


<210> 14821
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14821
agucgguaag ut                                                           12


<210> 14822
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14822
agucgguaag t                                                            11


<210> 14823
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14823
cagucgguaa guucugucca                                                   20


<210> 14824
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14824
cagucgguaa guucugucc                                                    19


<210> 14825
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14825
cagucgguaa guucuguc                                                     18


<210> 14826
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14826
cagucgguaa guucugt                                                      17


<210> 14827
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14827
cagucgguaa guucug                                                       16


<210> 14828
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14828
cagucgguaa guuct                                                        15


<210> 14829
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14829
cagucgguaa guuc                                                         14


<210> 14830
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14830
cagucgguaa gut                                                          13


<210> 14831
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14831
cagucgguaa gt                                                           12


<210> 14832
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14832
ccagucggua aguucugucc                                                   20


<210> 14833
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14833
ccagucggua aguucuguc                                                    19


<210> 14834
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14834
ccagucggua aguucugt                                                     18


<210> 14835
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14835
ccagucggua aguucug                                                      17


<210> 14836
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14836
ccagucggua aguuct                                                       16


<210> 14837
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14837
ccagucggua aguuc                                                        15


<210> 14838
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14838
ccagucggua agut                                                         14


<210> 14839
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14839
ccagucggua agt                                                          13


<210> 14840
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14840
gccagucggu aaguucuguc                                                   20


<210> 14841
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14841
gccagucggu aaguucugt                                                    19


<210> 14842
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14842
gccagucggu aaguucug                                                     18


<210> 14843
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14843
gccagucggu aaguuct                                                      17


<210> 14844
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14844
gccagucggu aaguuc                                                       16


<210> 14845
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14845
gccagucggu aagut                                                        15


<210> 14846
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14846
gccagucggu aagt                                                         14


<210> 14847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14847
ucaaggaaga uggcauuuct                                                   20


<210> 14848
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14848
ucaaggaaga uggcauuucu ag                                                22


<210> 14849
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14849
ucaaggaaga uggcat                                                       16


<210> 14850
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14850
gaagauggca uuuct                                                        15


<210> 14851
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14851
ucaaggaaga uggcauuucu a                                                 21


<210> 14852
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14852
ucaaggaaga uggcauuuc                                                    19


<210> 14853
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14853
ucaaggaaga uggcauut                                                     18


<210> 14854
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14854
ucaaggaaga uggcaut                                                      17


<210> 14855
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14855
ucaaggaaga uggca                                                        15


<210> 14856
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14856
ucaaggaaga uggc                                                         14


<210> 14857
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14857
ucaaggaaga ugg                                                          13


<210> 14858
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14858
ucaaggaaga ug                                                           12


<210> 14859
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14859
ucaaggaaga t                                                            11


<210> 14860
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14860
ucaaggaaga                                                              10


<210> 14861
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14861
ucaaggaag                                                                9


<210> 14862
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14862
caaggaagau ggcauuucua g                                                 21


<210> 14863
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14863
caaggaagau ggcauuucua                                                   20


<210> 14864
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14864
caaggaagau ggcauuuct                                                    19


<210> 14865
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 14865
caaggaagau ggcauuuc                                                     18


<210> 14866
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14866
caaggaagau ggcauut                                                      17


<210> 14867
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14867
caaggaagau ggcaut                                                       16


<210> 14868
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14868
caaggaagau ggcat                                                        15


<210> 14869
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14869
caaggaagau ggca                                                         14


<210> 14870
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14870
caaggaagau ggc                                                          13


<210> 14871
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14871
caaggaagau gg                                                           12


<210> 14872
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14872
caaggaagau g                                                            11


<210> 14873
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14873
caaggaagat                                                              10


<210> 14874
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14874
caaggaaga                                                                9


<210> 14875
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14875
caaggaag                                                                 8


<210> 14876
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14876
aaggaagaug gcauuucuag                                                   20


<210> 14877
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14877
aaggaagaug gcauuucua                                                    19


<210> 14878
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14878
aaggaagaug gcauuuct                                                     18


<210> 14879
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 14879
aaggaagaug gcauuuc                                                      17


<210> 14880
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14880
aaggaagaug gcauut                                                       16


<210> 14881
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14881
aaggaagaug gcaut                                                        15


<210> 14882
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14882
aaggaagaug gcat                                                         14


<210> 14883
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14883
aaggaagaug gca                                                          13


<210> 14884
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14884
aaggaagaug gc                                                           12


<210> 14885
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14885
aaggaagaug g                                                            11


<210> 14886
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14886
aaggaagaug                                                              10


<210> 14887
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14887
aaggaagat                                                                9


<210> 14888
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14888
aaggaaga                                                                 8


<210> 14889
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14889
aggaagaugg cauuucuag                                                    19


<210> 14890
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14890
aggaagaugg cauuucua                                                     18


<210> 14891
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14891
aggaagaugg cauuuct                                                      17


<210> 14892
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 14892
aggaagaugg cauuuc                                                       16


<210> 14893
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14893
aggaagaugg cauut                                                        15


<210> 14894
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14894
aggaagaugg caut                                                         14


<210> 14895
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14895
aggaagaugg cat                                                          13


<210> 14896
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14896
aggaagaugg ca                                                           12


<210> 14897
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14897
aggaagaugg                                                              10


<210> 14898
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14898
aggaagaug                                                                9


<210> 14899
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14899
aggaagat                                                                 8


<210> 14900
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14900
ggaagauggc auuucuag                                                     18


<210> 14901
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14901
ggaagauggc auuucua                                                      17


<210> 14902
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14902
ggaagauggc auuuct                                                       16


<210> 14903
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 14903
ggaagauggc auuuc                                                        15


<210> 14904
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14904
ggaagauggc auut                                                         14


<210> 14905
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14905
ggaagauggc aut                                                          13


<210> 14906
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14906
ggaagauggc at                                                           12


<210> 14907
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14907
ggaagauggc a                                                            11


<210> 14908
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 14908
ggaagauggc                                                              10


<210> 14909
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14909
ggaagaug                                                                 8


<210> 14910
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14910
gaagauggca uuucuag                                                      17


<210> 14911
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14911
gaagauggca uuucua                                                       16


<210> 14912
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 14912
gaagauggca uuuc                                                         14


<210> 14913
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14913
gaagauggca uut                                                          13


<210> 14914
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14914
gaagauggca ut                                                           12


<210> 14915
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14915
gaagauggca t                                                            11


<210> 14916
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14916
gaagauggca                                                              10


<210> 14917
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 14917
gaagauggc                                                                9


<210> 14918
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14918
gaagaugg                                                                 8


<210> 14919
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14919
aagauggcau uucuag                                                       16


<210> 14920
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14920
aagauggcau uucua                                                        15


<210> 14921
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14921
aagauggcau uuct                                                         14


<210> 14922
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 14922
aagauggcau uuc                                                          13


<210> 14923
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 14923
aagauggcau ut                                                           12


<210> 14924
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14924
aagauggcau t                                                            11


<210> 14925
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14925
aagauggcat                                                              10


<210> 14926
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14926
aagauggca                                                                9


<210> 14927
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 14927
aagauggc                                                                 8


<210> 14928
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14928
agauggcauu ucuag                                                        15


<210> 14929
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14929
agauggcauu ucua                                                         14


<210> 14930
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 14930
agauggcauu uct                                                          13


<210> 14931
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 14931
agauggcauu uc                                                           12


<210> 14932
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 14932
agauggcauu t                                                            11


<210> 14933
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 14933
agauggcaut                                                              10


<210> 14934
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 14934
agauggcat                                                                9


<210> 14935
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 14935
agauggca                                                                 8


<210> 14936
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 14936
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 14937
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 14937
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 14938
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 14938
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 14939
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<400> 14939
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 14940
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 14940
cuccaacauc aaggaagaug gcauut                                            26


<210> 14941
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 14941
cuccaacauc aaggaagaug gcaut                                             25


<210> 14942
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 14942
cuccaacauc aaggaagaug gcat                                              24


<210> 14943
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14943
cuccaacauc aaggaagaug gca                                               23


<210> 14944
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 14944
cuccaacauc aaggaagaug gc                                                22


<210> 14945
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14945
cuccaacauc aaggaagaug g                                                 21


<210> 14946
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14946
cuccaacauc aaggaagaug                                                   20


<210> 14947
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14947
cuccaacauc aaggaagat                                                    19


<210> 14948
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14948
cuccaacauc aaggaaga                                                     18


<210> 14949
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14949
cuccaacauc aaggaag                                                      17


<210> 14950
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 14950
uccaacauca aggaagaugg cauuucuag                                         29


<210> 14951
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 14951
uccaacauca aggaagaugg cauuucua                                          28


<210> 14952
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 14952
uccaacauca aggaagaugg cauuuct                                           27


<210> 14953
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<400> 14953
uccaacauca aggaagaugg cauuuc                                            26


<210> 14954
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 14954
uccaacauca aggaagaugg cauut                                             25


<210> 14955
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 14955
uccaacauca aggaagaugg caut                                              24


<210> 14956
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14956
uccaacauca aggaagaugg cat                                               23


<210> 14957
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14957
uccaacauca aggaagaugg ca                                                22


<210> 14958
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 14958
uccaacauca aggaagaugg c                                                 21


<210> 14959
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14959
uccaacauca aggaagaugg                                                   20


<210> 14960
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14960
uccaacauca aggaagaug                                                    19


<210> 14961
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14961
uccaacauca aggaagat                                                     18


<210> 14962
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14962
uccaacauca aggaaga                                                      17


<210> 14963
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14963
uccaacauca aggaag                                                       16


<210> 14964
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 14964
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 14965
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 14965
ccaacaucaa ggaagauggc auuucua                                           27


<210> 14966
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 14966
ccaacaucaa ggaagauggc auuuct                                            26


<210> 14967
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<400> 14967
ccaacaucaa ggaagauggc auuuc                                             25


<210> 14968
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 14968
ccaacaucaa ggaagauggc auut                                              24


<210> 14969
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14969
ccaacaucaa ggaagauggc aut                                               23


<210> 14970
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14970
ccaacaucaa ggaagauggc at                                                22


<210> 14971
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14971
ccaacaucaa ggaagauggc a                                                 21


<210> 14972
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 14972
ccaacaucaa ggaagauggc                                                   20


<210> 14973
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14973
ccaacaucaa ggaagaugg                                                    19


<210> 14974
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14974
ccaacaucaa ggaagaug                                                     18


<210> 14975
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14975
ccaacaucaa ggaagat                                                      17


<210> 14976
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14976
ccaacaucaa ggaaga                                                       16


<210> 14977
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14977
ccaacaucaa ggaag                                                        15


<210> 14978
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 14978
caacaucaag gaagauggca uuucuag                                           27


<210> 14979
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 14979
caacaucaag gaagauggca uuucua                                            26


<210> 14980
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 14980
caacaucaag gaagauggca uuuct                                             25


<210> 14981
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<400> 14981
caacaucaag gaagauggca uuuc                                              24


<210> 14982
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 14982
caacaucaag gaagauggca uut                                               23


<210> 14983
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14983
caacaucaag gaagauggca ut                                                22


<210> 14984
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14984
caacaucaag gaagauggca t                                                 21


<210> 14985
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14985
caacaucaag gaagauggca                                                   20


<210> 14986
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 14986
caacaucaag gaagauggc                                                    19


<210> 14987
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 14987
caacaucaag gaagaugg                                                     18


<210> 14988
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 14988
caacaucaag gaagaug                                                      17


<210> 14989
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 14989
caacaucaag gaagat                                                       16


<210> 14990
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 14990
caacaucaag gaaga                                                        15


<210> 14991
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 14991
caacaucaag gaag                                                         14


<210> 14992
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 14992
aacaucaagg aagauggcau uucuag                                            26


<210> 14993
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 14993
aacaucaagg aagauggcau uucua                                             25


<210> 14994
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 14994
aacaucaagg aagauggcau uuct                                              24


<210> 14995
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 14995
aacaucaagg aagauggcau uuc                                               23


<210> 14996
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 14996
aacaucaagg aagauggcau ut                                                22


<210> 14997
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 14997
aacaucaagg aagauggcau t                                                 21


<210> 14998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 14998
aacaucaagg aagauggcat                                                   20


<210> 14999
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 14999
aacaucaagg aagauggca                                                    19


<210> 15000
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 15000
aacaucaagg aagauggc                                                     18


<210> 15001
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15001
aacaucaagg aagaugg                                                      17


<210> 15002
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 15002
aacaucaagg aagaug                                                       16


<210> 15003
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 15003
aacaucaagg aagat                                                        15


<210> 15004
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 15004
aacaucaagg aaga                                                         14


<210> 15005
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 15005
aacaucaagg aag                                                          13


<210> 15006
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 15006
acaucaagga agauggcauu ucuag                                             25


<210> 15007
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 15007
acaucaagga agauggcauu ucua                                              24


<210> 15008
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 15008
acaucaagga agauggcauu uct                                               23


<210> 15009
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 15009
acaucaagga agauggcauu uc                                                22


<210> 15010
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 15010
acaucaagga agauggcauu t                                                 21


<210> 15011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 15011
acaucaagga agauggcaut                                                   20


<210> 15012
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15012
acaucaagga agauggcat                                                    19


<210> 15013
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15013
acaucaagga agauggca                                                     18


<210> 15014
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 15014
acaucaagga agauggc                                                      17


<210> 15015
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 15015
acaucaagga agaugg                                                       16


<210> 15016
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 15016
acaucaagga agaug                                                        15


<210> 15017
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 15017
acaucaagga agat                                                         14


<210> 15018
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 15018
acaucaagga aga                                                          13


<210> 15019
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 15019
acaucaagga ag                                                           12


<210> 15020
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 15020
caucaaggaa gauggcauuu cuag                                              24


<210> 15021
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 15021
caucaaggaa gauggcauuu cua                                               23


<210> 15022
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 15022
caucaaggaa gauggcauuu ct                                                22


<210> 15023
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 15023
caucaaggaa gauggcauuu c                                                 21


<210> 15024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 15024
caucaaggaa gauggcauut                                                   20


<210> 15025
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15025
caucaaggaa gauggcaut                                                    19


<210> 15026
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15026
caucaaggaa gauggcat                                                     18


<210> 15027
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15027
caucaaggaa gauggca                                                      17


<210> 15028
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 15028
caucaaggaa gauggc                                                       16


<210> 15029
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 15029
caucaaggaa gaugg                                                        15


<210> 15030
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 15030
caucaaggaa gaug                                                         14


<210> 15031
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 15031
caucaaggaa gat                                                          13


<210> 15032
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 15032
caucaaggaa ga                                                           12


<210> 15033
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 15033
caucaaggaa g                                                            11


<210> 15034
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 15034
aucaaggaag auggcauuuc uag                                               23


<210> 15035
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 15035
aucaaggaag auggcauuuc ua                                                22


<210> 15036
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 15036
aucaaggaag auggcauuuc t                                                 21


<210> 15037
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 15037
aucaaggaag auggcauuuc                                                   20


<210> 15038
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15038
aucaaggaag auggcauut                                                    19


<210> 15039
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15039
aucaaggaag auggcaut                                                     18


<210> 15040
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15040
aucaaggaag auggcat                                                      17


<210> 15041
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 15041
aucaaggaag auggca                                                       16


<210> 15042
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 15042
aucaaggaag auggc                                                        15


<210> 15043
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 15043
aucaaggaag augg                                                         14


<210> 15044
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 15044
aucaaggaag aug                                                          13


<210> 15045
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 15045
aucaaggaag at                                                           12


<210> 15046
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 15046
aucaaggaag a                                                            11


<210> 15047
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 15047
aucaaggaag                                                              10


<210> 15048
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 15048
ccagagcagg uaccuccaac auc                                               23


<210> 15049
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15049
ccagagcagg uaccucca                                                     18


<210> 15050
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 15050
ccucugugau uuuauaacuu gat                                               23


<210> 15051
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15051
ucacccacca ucaccct                                                      17


<210> 15052
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 15052
ugauauccuc aaggucaccc                                                   20


<210> 15053
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 15053
cugcuugaug aucaucucgu ug                                                22


<210> 15054
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 15054
cugcuugaug aucaucuc                                                     18


<210> 15055
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15055
guuuccuuag uaaccacag                                                    19


<210> 15056
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 15056
guuuccuuag uaaccac                                                      17


<210> 15057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15057
ucaaggaaga uggcauuuct                                                   20


<210> 15058
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15058
ucaaggaaga uggcauuucu ag                                                22


<210> 15059
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15059
gguaaguucu guccaagc                                                     18


<210> 15060
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15060
guaaguucug uccaagcc                                                     18


<210> 15061
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15061
agucgguaag uucugucc                                                     18


<210> 15062
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15062
cuguccaagc ccgguuga                                                     18


<210> 15063
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15063
uaaguucugu ccaag                                                        15


<210> 15064
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15064
uucuguccaa gcccgguuga                                                   20


<210> 15065
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15065
uucuguccaa gcccgguug                                                    19


<210> 15066
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15066
uucuguccaa gcccggut                                                     18


<210> 15067
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15067
uucuguccaa gcccggt                                                      17


<210> 15068
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15068
uucuguccaa gcccgg                                                       16


<210> 15069
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15069
uucuguccaa gcccg                                                        15


<210> 15070
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15070
uucuguccaa gccc                                                         14


<210> 15071
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15071
uucuguccaa gcc                                                          13


<210> 15072
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15072
uucuguccaa gc                                                           12


<210> 15073
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15073
uucuguccaa g                                                            11


<210> 15074
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15074
uucuguccaa                                                              10


<210> 15075
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15075
uucugucca                                                                9


<210> 15076
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15076
uucugucc                                                                 8


<210> 15077
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15077
ucuguccaag cccgguuga                                                    19


<210> 15078
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15078
ucuguccaag cccgguug                                                     18


<210> 15079
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15079
ucuguccaag cccggut                                                      17


<210> 15080
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15080
ucuguccaag cccggt                                                       16


<210> 15081
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15081
ucuguccaag cccgg                                                        15


<210> 15082
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15082
ucuguccaag cccg                                                         14


<210> 15083
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15083
ucuguccaag ccc                                                          13


<210> 15084
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15084
ucuguccaag cc                                                           12


<210> 15085
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15085
ucuguccaag c                                                            11


<210> 15086
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15086
ucuguccaag                                                              10


<210> 15087
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15087
ucuguccaa                                                                9


<210> 15088
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15088
ucugucca                                                                 8


<210> 15089
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15089
cuguccaagc ccgguug                                                      17


<210> 15090
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15090
cuguccaagc ccggut                                                       16


<210> 15091
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15091
cuguccaagc ccggt                                                        15


<210> 15092
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15092
cuguccaagc ccgg                                                         14


<210> 15093
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15093
cuguccaagc ccg                                                          13


<210> 15094
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15094
cuguccaagc cc                                                           12


<210> 15095
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15095
cuguccaagc c                                                            11


<210> 15096
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15096
cuguccaagc                                                              10


<210> 15097
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15097
cuguccaag                                                                9


<210> 15098
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15098
cuguccaa                                                                 8


<210> 15099
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15099
guucugucca agcccgguug                                                   20


<210> 15100
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15100
guucugucca agcccggut                                                    19


<210> 15101
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15101
guucugucca agcccggt                                                     18


<210> 15102
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15102
guucugucca agcccgg                                                      17


<210> 15103
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15103
guucugucca agcccg                                                       16


<210> 15104
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15104
guucugucca agccc                                                        15


<210> 15105
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15105
guucugucca agcc                                                         14


<210> 15106
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15106
guucugucca agc                                                          13


<210> 15107
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15107
guucugucca ag                                                           12


<210> 15108
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15108
guucugucca a                                                            11


<210> 15109
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15109
guucugucca                                                              10


<210> 15110
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15110
guucugucc                                                                9


<210> 15111
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15111
guucuguc                                                                 8


<210> 15112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15112
aguucugucc aagcccggut                                                   20


<210> 15113
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15113
aguucugucc aagcccggt                                                    19


<210> 15114
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15114
aguucugucc aagcccgg                                                     18


<210> 15115
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15115
aguucugucc aagcccg                                                      17


<210> 15116
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15116
aguucugucc aagccc                                                       16


<210> 15117
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15117
aguucugucc aagcc                                                        15


<210> 15118
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15118
aguucugucc aagc                                                         14


<210> 15119
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15119
aguucugucc aag                                                          13


<210> 15120
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15120
aguucugucc aa                                                           12


<210> 15121
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15121
aguucugucc a                                                            11


<210> 15122
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15122
aguucugucc                                                              10


<210> 15123
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15123
aguucuguc                                                                9


<210> 15124
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15124
aguucugt                                                                 8


<210> 15125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15125
aaguucuguc caagcccggt                                                   20


<210> 15126
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15126
aaguucuguc caagcccgg                                                    19


<210> 15127
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15127
aaguucuguc caagcccg                                                     18


<210> 15128
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15128
aaguucuguc caagccc                                                      17


<210> 15129
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15129
aaguucuguc caagcc                                                       16


<210> 15130
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15130
aaguucuguc caagc                                                        15


<210> 15131
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15131
aaguucuguc caag                                                         14


<210> 15132
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15132
aaguucuguc caa                                                          13


<210> 15133
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15133
aaguucuguc ca                                                           12


<210> 15134
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15134
aaguucuguc c                                                            11


<210> 15135
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15135
aaguucuguc                                                              10


<210> 15136
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15136
aaguucugt                                                                9


<210> 15137
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15137
aaguucug                                                                 8


<210> 15138
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15138
uaaguucugu ccaagcccgg                                                   20


<210> 15139
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15139
uaaguucugu ccaagcccg                                                    19


<210> 15140
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15140
uaaguucugu ccaagccc                                                     18


<210> 15141
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15141
uaaguucugu ccaagcc                                                      17


<210> 15142
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15142
uaaguucugu ccaagc                                                       16


<210> 15143
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15143
uaaguucugu ccaa                                                         14


<210> 15144
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15144
uaaguucugu cca                                                          13


<210> 15145
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15145
uaaguucugu cc                                                           12


<210> 15146
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15146
uaaguucugu c                                                            11


<210> 15147
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15147
uaaguucugt                                                              10


<210> 15148
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15148
uaaguucug                                                                9


<210> 15149
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15149
uaaguuct                                                                 8


<210> 15150
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15150
guaaguucug uccaagcccg                                                   20


<210> 15151
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15151
guaaguucug uccaagccc                                                    19


<210> 15152
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15152
guaaguucug uccaagc                                                      17


<210> 15153
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15153
guaaguucug uccaag                                                       16


<210> 15154
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15154
guaaguucug uccaa                                                        15


<210> 15155
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15155
guaaguucug ucca                                                         14


<210> 15156
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15156
guaaguucug ucc                                                          13


<210> 15157
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15157
guaaguucug uc                                                           12


<210> 15158
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15158
guaaguucug t                                                            11


<210> 15159
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15159
guaaguucug                                                              10


<210> 15160
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15160
guaaguuct                                                                9


<210> 15161
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15161
guaaguuc                                                                 8


<210> 15162
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15162
gguaaguucu guccaagccc                                                   20


<210> 15163
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15163
gguaaguucu guccaagcc                                                    19


<210> 15164
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15164
gguaaguucu guccaag                                                      17


<210> 15165
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15165
gguaaguucu guccaa                                                       16


<210> 15166
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15166
gguaaguucu gucca                                                        15


<210> 15167
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15167
gguaaguucu gucc                                                         14


<210> 15168
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15168
gguaaguucu guc                                                          13


<210> 15169
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15169
gguaaguucu gt                                                           12


<210> 15170
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15170
gguaaguucu g                                                            11


<210> 15171
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15171
gguaaguuct                                                              10


<210> 15172
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15172
gguaaguuc                                                                9


<210> 15173
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15173
gguaagut                                                                 8


<210> 15174
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15174
cgguaaguuc uguccaagcc                                                   20


<210> 15175
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15175
cgguaaguuc uguccaagc                                                    19


<210> 15176
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15176
cgguaaguuc uguccaag                                                     18


<210> 15177
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15177
cgguaaguuc uguccaa                                                      17


<210> 15178
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15178
cgguaaguuc ugucca                                                       16


<210> 15179
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15179
cgguaaguuc ugucc                                                        15


<210> 15180
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15180
cgguaaguuc uguc                                                         14


<210> 15181
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15181
cgguaaguuc ugt                                                          13


<210> 15182
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15182
cgguaaguuc ug                                                           12


<210> 15183
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15183
cgguaaguuc t                                                            11


<210> 15184
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15184
cgguaaguuc                                                              10


<210> 15185
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15185
cgguaagut                                                                9


<210> 15186
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15186
cgguaagt                                                                 8


<210> 15187
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15187
ucgguaaguu cuguccaagc                                                   20


<210> 15188
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15188
ucgguaaguu cuguccaag                                                    19


<210> 15189
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15189
ucgguaaguu cuguccaa                                                     18


<210> 15190
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15190
ucgguaaguu cugucca                                                      17


<210> 15191
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15191
ucgguaaguu cugucc                                                       16


<210> 15192
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15192
ucgguaaguu cuguc                                                        15


<210> 15193
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15193
ucgguaaguu cugt                                                         14


<210> 15194
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15194
ucgguaaguu cug                                                          13


<210> 15195
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15195
ucgguaaguu ct                                                           12


<210> 15196
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15196
ucgguaaguu c                                                            11


<210> 15197
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15197
ucgguaagut                                                              10


<210> 15198
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15198
ucgguaagt                                                                9


<210> 15199
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15199
gucgguaagu ucuguccaag                                                   20


<210> 15200
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15200
gucgguaagu ucuguccaa                                                    19


<210> 15201
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15201
gucgguaagu ucugucca                                                     18


<210> 15202
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15202
gucgguaagu ucugucc                                                      17


<210> 15203
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15203
gucgguaagu ucuguc                                                       16


<210> 15204
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15204
gucgguaagu ucugt                                                        15


<210> 15205
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15205
gucgguaagu ucug                                                         14


<210> 15206
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15206
gucgguaagu uct                                                          13


<210> 15207
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15207
gucgguaagu uc                                                           12


<210> 15208
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15208
gucgguaagu t                                                            11


<210> 15209
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15209
gucgguaagt                                                              10


<210> 15210
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15210
agucgguaag uucuguccaa                                                   20


<210> 15211
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15211
agucgguaag uucugucca                                                    19


<210> 15212
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15212
agucgguaag uucuguc                                                      17


<210> 15213
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15213
agucgguaag uucugt                                                       16


<210> 15214
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15214
agucgguaag uucug                                                        15


<210> 15215
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15215
agucgguaag uuct                                                         14


<210> 15216
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15216
agucgguaag uuc                                                          13


<210> 15217
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15217
agucgguaag ut                                                           12


<210> 15218
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15218
agucgguaag t                                                            11


<210> 15219
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15219
cagucgguaa guucugucca                                                   20


<210> 15220
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15220
cagucgguaa guucugucc                                                    19


<210> 15221
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15221
cagucgguaa guucuguc                                                     18


<210> 15222
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15222
cagucgguaa guucugt                                                      17


<210> 15223
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15223
cagucgguaa guucug                                                       16


<210> 15224
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15224
cagucgguaa guuct                                                        15


<210> 15225
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15225
cagucgguaa guuc                                                         14


<210> 15226
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15226
cagucgguaa gut                                                          13


<210> 15227
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15227
cagucgguaa gt                                                           12


<210> 15228
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15228
ccagucggua aguucugucc                                                   20


<210> 15229
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15229
ccagucggua aguucuguc                                                    19


<210> 15230
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15230
ccagucggua aguucugt                                                     18


<210> 15231
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15231
ccagucggua aguucug                                                      17


<210> 15232
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15232
ccagucggua aguuct                                                       16


<210> 15233
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15233
ccagucggua aguuc                                                        15


<210> 15234
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15234
ccagucggua agut                                                         14


<210> 15235
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15235
ccagucggua agt                                                          13


<210> 15236
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15236
gccagucggu aaguucuguc                                                   20


<210> 15237
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15237
gccagucggu aaguucugt                                                    19


<210> 15238
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15238
gccagucggu aaguucug                                                     18


<210> 15239
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15239
gccagucggu aaguuct                                                      17


<210> 15240
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15240
gccagucggu aaguuc                                                       16


<210> 15241
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15241
gccagucggu aagut                                                        15


<210> 15242
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15242
gccagucggu aagt                                                         14


<210> 15243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15243
ucaaggaaga uggcauuuct                                                   20


<210> 15244
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15244
ucaaggaaga uggcauuucu ag                                                22


<210> 15245
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15245
ucaaggaaga uggcat                                                       16


<210> 15246
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15246
gaagauggca uuuct                                                        15


<210> 15247
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15247
ucaaggaaga uggcauuucu a                                                 21


<210> 15248
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15248
ucaaggaaga uggcauuuc                                                    19


<210> 15249
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15249
ucaaggaaga uggcauut                                                     18


<210> 15250
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15250
ucaaggaaga uggcaut                                                      17


<210> 15251
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15251
ucaaggaaga uggca                                                        15


<210> 15252
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15252
ucaaggaaga uggc                                                         14


<210> 15253
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15253
ucaaggaaga ugg                                                          13


<210> 15254
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15254
ucaaggaaga ug                                                           12


<210> 15255
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15255
ucaaggaaga t                                                            11


<210> 15256
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15256
ucaaggaaga                                                              10


<210> 15257
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15257
ucaaggaag                                                                9


<210> 15258
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15258
caaggaagau ggcauuucua g                                                 21


<210> 15259
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15259
caaggaagau ggcauuucua                                                   20


<210> 15260
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15260
caaggaagau ggcauuuct                                                    19


<210> 15261
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15261
caaggaagau ggcauuuc                                                     18


<210> 15262
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15262
caaggaagau ggcauut                                                      17


<210> 15263
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15263
caaggaagau ggcaut                                                       16


<210> 15264
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15264
caaggaagau ggcat                                                        15


<210> 15265
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15265
caaggaagau ggca                                                         14


<210> 15266
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15266
caaggaagau ggc                                                          13


<210> 15267
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15267
caaggaagau gg                                                           12


<210> 15268
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15268
caaggaagau g                                                            11


<210> 15269
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15269
caaggaagat                                                              10


<210> 15270
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15270
caaggaaga                                                                9


<210> 15271
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15271
caaggaag                                                                 8


<210> 15272
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15272
aaggaagaug gcauuucuag                                                   20


<210> 15273
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15273
aaggaagaug gcauuucua                                                    19


<210> 15274
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15274
aaggaagaug gcauuuct                                                     18


<210> 15275
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15275
aaggaagaug gcauuuc                                                      17


<210> 15276
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15276
aaggaagaug gcauut                                                       16


<210> 15277
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15277
aaggaagaug gcaut                                                        15


<210> 15278
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15278
aaggaagaug gcat                                                         14


<210> 15279
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15279
aaggaagaug gca                                                          13


<210> 15280
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15280
aaggaagaug gc                                                           12


<210> 15281
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15281
aaggaagaug g                                                            11


<210> 15282
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15282
aaggaagaug                                                              10


<210> 15283
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15283
aaggaagat                                                                9


<210> 15284
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15284
aaggaaga                                                                 8


<210> 15285
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15285
aggaagaugg cauuucuag                                                    19


<210> 15286
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15286
aggaagaugg cauuucua                                                     18


<210> 15287
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15287
aggaagaugg cauuuct                                                      17


<210> 15288
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15288
aggaagaugg cauuuc                                                       16


<210> 15289
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15289
aggaagaugg cauut                                                        15


<210> 15290
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15290
aggaagaugg caut                                                         14


<210> 15291
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15291
aggaagaugg cat                                                          13


<210> 15292
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15292
aggaagaugg ca                                                           12


<210> 15293
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15293
aggaagaugg                                                              10


<210> 15294
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15294
aggaagaug                                                                9


<210> 15295
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15295
aggaagat                                                                 8


<210> 15296
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15296
ggaagauggc auuucuag                                                     18


<210> 15297
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15297
ggaagauggc auuucua                                                      17


<210> 15298
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15298
ggaagauggc auuuct                                                       16


<210> 15299
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15299
ggaagauggc auuuc                                                        15


<210> 15300
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15300
ggaagauggc auut                                                         14


<210> 15301
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15301
ggaagauggc aut                                                          13


<210> 15302
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15302
ggaagauggc at                                                           12


<210> 15303
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15303
ggaagauggc a                                                            11


<210> 15304
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15304
ggaagauggc                                                              10


<210> 15305
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15305
ggaagaug                                                                 8


<210> 15306
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15306
gaagauggca uuucuag                                                      17


<210> 15307
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15307
gaagauggca uuucua                                                       16


<210> 15308
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15308
gaagauggca uuuc                                                         14


<210> 15309
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15309
gaagauggca uut                                                          13


<210> 15310
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15310
gaagauggca ut                                                           12


<210> 15311
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15311
gaagauggca t                                                            11


<210> 15312
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15312
gaagauggca                                                              10


<210> 15313
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15313
gaagauggc                                                                9


<210> 15314
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15314
gaagaugg                                                                 8


<210> 15315
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15315
aagauggcau uucuag                                                       16


<210> 15316
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15316
aagauggcau uucua                                                        15


<210> 15317
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15317
aagauggcau uuct                                                         14


<210> 15318
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15318
aagauggcau uuc                                                          13


<210> 15319
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15319
aagauggcau ut                                                           12


<210> 15320
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15320
aagauggcau t                                                            11


<210> 15321
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15321
aagauggcat                                                              10


<210> 15322
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15322
aagauggca                                                                9


<210> 15323
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15323
aagauggc                                                                 8


<210> 15324
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15324
agauggcauu ucuag                                                        15


<210> 15325
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15325
agauggcauu ucua                                                         14


<210> 15326
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15326
agauggcauu uct                                                          13


<210> 15327
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15327
agauggcauu uc                                                           12


<210> 15328
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15328
agauggcauu t                                                            11


<210> 15329
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15329
agauggcaut                                                              10


<210> 15330
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15330
agauggcat                                                                9


<210> 15331
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15331
agauggca                                                                 8


<210> 15332
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15332
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 15333
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15333
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 15334
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15334
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 15335
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15335
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 15336
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15336
cuccaacauc aaggaagaug gcauut                                            26


<210> 15337
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15337
cuccaacauc aaggaagaug gcaut                                             25


<210> 15338
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15338
cuccaacauc aaggaagaug gcat                                              24


<210> 15339
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15339
cuccaacauc aaggaagaug gca                                               23


<210> 15340
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15340
cuccaacauc aaggaagaug gc                                                22


<210> 15341
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15341
cuccaacauc aaggaagaug g                                                 21


<210> 15342
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15342
cuccaacauc aaggaagaug                                                   20


<210> 15343
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15343
cuccaacauc aaggaagat                                                    19


<210> 15344
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15344
cuccaacauc aaggaaga                                                     18


<210> 15345
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15345
cuccaacauc aaggaag                                                      17


<210> 15346
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15346
uccaacauca aggaagaugg cauuucuag                                         29


<210> 15347
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15347
uccaacauca aggaagaugg cauuucua                                          28


<210> 15348
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15348
uccaacauca aggaagaugg cauuuct                                           27


<210> 15349
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15349
uccaacauca aggaagaugg cauuuc                                            26


<210> 15350
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15350
uccaacauca aggaagaugg cauut                                             25


<210> 15351
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15351
uccaacauca aggaagaugg caut                                              24


<210> 15352
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15352
uccaacauca aggaagaugg cat                                               23


<210> 15353
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15353
uccaacauca aggaagaugg ca                                                22


<210> 15354
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15354
uccaacauca aggaagaugg c                                                 21


<210> 15355
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15355
uccaacauca aggaagaugg                                                   20


<210> 15356
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15356
uccaacauca aggaagaug                                                    19


<210> 15357
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15357
uccaacauca aggaagat                                                     18


<210> 15358
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15358
uccaacauca aggaaga                                                      17


<210> 15359
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15359
uccaacauca aggaag                                                       16


<210> 15360
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15360
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 15361
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15361
ccaacaucaa ggaagauggc auuucua                                           27


<210> 15362
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15362
ccaacaucaa ggaagauggc auuuct                                            26


<210> 15363
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15363
ccaacaucaa ggaagauggc auuuc                                             25


<210> 15364
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15364
ccaacaucaa ggaagauggc auut                                              24


<210> 15365
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15365
ccaacaucaa ggaagauggc aut                                               23


<210> 15366
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15366
ccaacaucaa ggaagauggc at                                                22


<210> 15367
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15367
ccaacaucaa ggaagauggc a                                                 21


<210> 15368
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15368
ccaacaucaa ggaagauggc                                                   20


<210> 15369
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15369
ccaacaucaa ggaagaugg                                                    19


<210> 15370
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15370
ccaacaucaa ggaagaug                                                     18


<210> 15371
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15371
ccaacaucaa ggaagat                                                      17


<210> 15372
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15372
ccaacaucaa ggaaga                                                       16


<210> 15373
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15373
ccaacaucaa ggaag                                                        15


<210> 15374
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15374
caacaucaag gaagauggca uuucuag                                           27


<210> 15375
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15375
caacaucaag gaagauggca uuucua                                            26


<210> 15376
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15376
caacaucaag gaagauggca uuuct                                             25


<210> 15377
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15377
caacaucaag gaagauggca uuuc                                              24


<210> 15378
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15378
caacaucaag gaagauggca uut                                               23


<210> 15379
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15379
caacaucaag gaagauggca ut                                                22


<210> 15380
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15380
caacaucaag gaagauggca t                                                 21


<210> 15381
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15381
caacaucaag gaagauggca                                                   20


<210> 15382
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15382
caacaucaag gaagauggc                                                    19


<210> 15383
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15383
caacaucaag gaagaugg                                                     18


<210> 15384
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15384
caacaucaag gaagaug                                                      17


<210> 15385
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15385
caacaucaag gaagat                                                       16


<210> 15386
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15386
caacaucaag gaaga                                                        15


<210> 15387
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15387
caacaucaag gaag                                                         14


<210> 15388
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15388
aacaucaagg aagauggcau uucuag                                            26


<210> 15389
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15389
aacaucaagg aagauggcau uucua                                             25


<210> 15390
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15390
aacaucaagg aagauggcau uuct                                              24


<210> 15391
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15391
aacaucaagg aagauggcau uuc                                               23


<210> 15392
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15392
aacaucaagg aagauggcau ut                                                22


<210> 15393
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15393
aacaucaagg aagauggcau t                                                 21


<210> 15394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15394
aacaucaagg aagauggcat                                                   20


<210> 15395
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15395
aacaucaagg aagauggca                                                    19


<210> 15396
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15396
aacaucaagg aagauggc                                                     18


<210> 15397
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15397
aacaucaagg aagaugg                                                      17


<210> 15398
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15398
aacaucaagg aagaug                                                       16


<210> 15399
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15399
aacaucaagg aagat                                                        15


<210> 15400
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15400
aacaucaagg aaga                                                         14


<210> 15401
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15401
aacaucaagg aag                                                          13


<210> 15402
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15402
acaucaagga agauggcauu ucuag                                             25


<210> 15403
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15403
acaucaagga agauggcauu ucua                                              24


<210> 15404
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15404
acaucaagga agauggcauu uct                                               23


<210> 15405
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15405
acaucaagga agauggcauu uc                                                22


<210> 15406
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15406
acaucaagga agauggcauu t                                                 21


<210> 15407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15407
acaucaagga agauggcaut                                                   20


<210> 15408
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15408
acaucaagga agauggcat                                                    19


<210> 15409
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15409
acaucaagga agauggca                                                     18


<210> 15410
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15410
acaucaagga agauggc                                                      17


<210> 15411
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15411
acaucaagga agaugg                                                       16


<210> 15412
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15412
acaucaagga agaug                                                        15


<210> 15413
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15413
acaucaagga agat                                                         14


<210> 15414
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15414
acaucaagga aga                                                          13


<210> 15415
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15415
acaucaagga ag                                                           12


<210> 15416
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15416
caucaaggaa gauggcauuu cuag                                              24


<210> 15417
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15417
caucaaggaa gauggcauuu cua                                               23


<210> 15418
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15418
caucaaggaa gauggcauuu ct                                                22


<210> 15419
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15419
caucaaggaa gauggcauuu c                                                 21


<210> 15420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15420
caucaaggaa gauggcauut                                                   20


<210> 15421
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15421
caucaaggaa gauggcaut                                                    19


<210> 15422
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15422
caucaaggaa gauggcat                                                     18


<210> 15423
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15423
caucaaggaa gauggca                                                      17


<210> 15424
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15424
caucaaggaa gauggc                                                       16


<210> 15425
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15425
caucaaggaa gaugg                                                        15


<210> 15426
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15426
caucaaggaa gaug                                                         14


<210> 15427
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15427
caucaaggaa gat                                                          13


<210> 15428
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15428
caucaaggaa ga                                                           12


<210> 15429
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15429
caucaaggaa g                                                            11


<210> 15430
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15430
aucaaggaag auggcauuuc uag                                               23


<210> 15431
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15431
aucaaggaag auggcauuuc ua                                                22


<210> 15432
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15432
aucaaggaag auggcauuuc t                                                 21


<210> 15433
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15433
aucaaggaag auggcauuuc                                                   20


<210> 15434
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15434
aucaaggaag auggcauut                                                    19


<210> 15435
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15435
aucaaggaag auggcaut                                                     18


<210> 15436
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15436
aucaaggaag auggcat                                                      17


<210> 15437
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15437
aucaaggaag auggca                                                       16


<210> 15438
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15438
aucaaggaag auggc                                                        15


<210> 15439
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15439
aucaaggaag augg                                                         14


<210> 15440
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15440
aucaaggaag aug                                                          13


<210> 15441
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15441
aucaaggaag at                                                           12


<210> 15442
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15442
aucaaggaag a                                                            11


<210> 15443
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15443
aucaaggaag                                                              10


<210> 15444
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15444
ccagagcagg uaccuccaac auc                                               23


<210> 15445
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15445
ccagagcagg uaccucca                                                     18


<210> 15446
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15446
ccucugugau uuuauaacuu gat                                               23


<210> 15447
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15447
ucacccacca ucaccct                                                      17


<210> 15448
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15448
ugauauccuc aaggucaccc                                                   20


<210> 15449
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15449
cugcuugaug aucaucucgu ug                                                22


<210> 15450
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15450
cugcuugaug aucaucuc                                                     18


<210> 15451
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15451
guuuccuuag uaaccacag                                                    19


<210> 15452
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15452
guuuccuuag uaaccac                                                      17


<210> 15453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15453
ucaaggaaga uggcauuuct                                                   20


<210> 15454
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15454
ucaaggaaga uggcauuucu ag                                                22


<210> 15455
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15455
gguaaguucu guccaagc                                                     18


<210> 15456
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15456
guaaguucug uccaagcc                                                     18


<210> 15457
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15457
agucgguaag uucugucc                                                     18


<210> 15458
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15458
cuguccaagc ccgguuga                                                     18


<210> 15459
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15459
uaaguucugu ccaag                                                        15


<210> 15460
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15460
uucuguccaa gcccgguuga                                                   20


<210> 15461
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15461
uucuguccaa gcccgguug                                                    19


<210> 15462
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15462
uucuguccaa gcccggut                                                     18


<210> 15463
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15463
uucuguccaa gcccggt                                                      17


<210> 15464
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15464
uucuguccaa gcccgg                                                       16


<210> 15465
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15465
uucuguccaa gcccg                                                        15


<210> 15466
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15466
uucuguccaa gccc                                                         14


<210> 15467
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15467
uucuguccaa gcc                                                          13


<210> 15468
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15468
uucuguccaa gc                                                           12


<210> 15469
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15469
uucuguccaa g                                                            11


<210> 15470
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15470
uucuguccaa                                                              10


<210> 15471
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15471
uucugucca                                                                9


<210> 15472
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15472
uucugucc                                                                 8


<210> 15473
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15473
ucuguccaag cccgguuga                                                    19


<210> 15474
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15474
ucuguccaag cccgguug                                                     18


<210> 15475
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15475
ucuguccaag cccggut                                                      17


<210> 15476
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15476
ucuguccaag cccggt                                                       16


<210> 15477
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15477
ucuguccaag cccgg                                                        15


<210> 15478
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15478
ucuguccaag cccg                                                         14


<210> 15479
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15479
ucuguccaag ccc                                                          13


<210> 15480
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15480
ucuguccaag cc                                                           12


<210> 15481
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15481
ucuguccaag c                                                            11


<210> 15482
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15482
ucuguccaag                                                              10


<210> 15483
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15483
ucuguccaa                                                                9


<210> 15484
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15484
ucugucca                                                                 8


<210> 15485
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15485
cuguccaagc ccgguug                                                      17


<210> 15486
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15486
cuguccaagc ccggut                                                       16


<210> 15487
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15487
cuguccaagc ccggt                                                        15


<210> 15488
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15488
cuguccaagc ccgg                                                         14


<210> 15489
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15489
cuguccaagc ccg                                                          13


<210> 15490
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15490
cuguccaagc cc                                                           12


<210> 15491
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15491
cuguccaagc c                                                            11


<210> 15492
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15492
cuguccaagc                                                              10


<210> 15493
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15493
cuguccaag                                                                9


<210> 15494
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15494
cuguccaa                                                                 8


<210> 15495
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15495
guucugucca agcccgguug                                                   20


<210> 15496
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15496
guucugucca agcccggut                                                    19


<210> 15497
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15497
guucugucca agcccggt                                                     18


<210> 15498
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15498
guucugucca agcccgg                                                      17


<210> 15499
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15499
guucugucca agcccg                                                       16


<210> 15500
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15500
guucugucca agccc                                                        15


<210> 15501
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15501
guucugucca agcc                                                         14


<210> 15502
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15502
guucugucca agc                                                          13


<210> 15503
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15503
guucugucca ag                                                           12


<210> 15504
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15504
guucugucca a                                                            11


<210> 15505
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15505
guucugucca                                                              10


<210> 15506
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15506
guucugucc                                                                9


<210> 15507
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15507
guucuguc                                                                 8


<210> 15508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15508
aguucugucc aagcccggut                                                   20


<210> 15509
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15509
aguucugucc aagcccggt                                                    19


<210> 15510
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15510
aguucugucc aagcccgg                                                     18


<210> 15511
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15511
aguucugucc aagcccg                                                      17


<210> 15512
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15512
aguucugucc aagccc                                                       16


<210> 15513
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15513
aguucugucc aagcc                                                        15


<210> 15514
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15514
aguucugucc aagc                                                         14


<210> 15515
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15515
aguucugucc aag                                                          13


<210> 15516
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15516
aguucugucc aa                                                           12


<210> 15517
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15517
aguucugucc a                                                            11


<210> 15518
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15518
aguucugucc                                                              10


<210> 15519
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15519
aguucuguc                                                                9


<210> 15520
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15520
aguucugt                                                                 8


<210> 15521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15521
aaguucuguc caagcccggt                                                   20


<210> 15522
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15522
aaguucuguc caagcccgg                                                    19


<210> 15523
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15523
aaguucuguc caagcccg                                                     18


<210> 15524
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15524
aaguucuguc caagccc                                                      17


<210> 15525
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15525
aaguucuguc caagcc                                                       16


<210> 15526
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15526
aaguucuguc caagc                                                        15


<210> 15527
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15527
aaguucuguc caag                                                         14


<210> 15528
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15528
aaguucuguc caa                                                          13


<210> 15529
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15529
aaguucuguc ca                                                           12


<210> 15530
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15530
aaguucuguc c                                                            11


<210> 15531
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15531
aaguucuguc                                                              10


<210> 15532
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15532
aaguucugt                                                                9


<210> 15533
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15533
aaguucug                                                                 8


<210> 15534
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15534
uaaguucugu ccaagcccgg                                                   20


<210> 15535
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15535
uaaguucugu ccaagcccg                                                    19


<210> 15536
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15536
uaaguucugu ccaagccc                                                     18


<210> 15537
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15537
uaaguucugu ccaagcc                                                      17


<210> 15538
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15538
uaaguucugu ccaagc                                                       16


<210> 15539
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15539
uaaguucugu ccaa                                                         14


<210> 15540
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15540
uaaguucugu cca                                                          13


<210> 15541
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15541
uaaguucugu cc                                                           12


<210> 15542
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15542
uaaguucugu c                                                            11


<210> 15543
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15543
uaaguucugt                                                              10


<210> 15544
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15544
uaaguucug                                                                9


<210> 15545
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15545
uaaguuct                                                                 8


<210> 15546
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15546
guaaguucug uccaagcccg                                                   20


<210> 15547
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15547
guaaguucug uccaagccc                                                    19


<210> 15548
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15548
guaaguucug uccaagc                                                      17


<210> 15549
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15549
guaaguucug uccaag                                                       16


<210> 15550
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15550
guaaguucug uccaa                                                        15


<210> 15551
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15551
guaaguucug ucca                                                         14


<210> 15552
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15552
guaaguucug ucc                                                          13


<210> 15553
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15553
guaaguucug uc                                                           12


<210> 15554
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15554
guaaguucug t                                                            11


<210> 15555
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15555
guaaguucug                                                              10


<210> 15556
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15556
guaaguuct                                                                9


<210> 15557
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15557
guaaguuc                                                                 8


<210> 15558
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15558
gguaaguucu guccaagccc                                                   20


<210> 15559
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15559
gguaaguucu guccaagcc                                                    19


<210> 15560
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15560
gguaaguucu guccaag                                                      17


<210> 15561
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15561
gguaaguucu guccaa                                                       16


<210> 15562
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15562
gguaaguucu gucca                                                        15


<210> 15563
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15563
gguaaguucu gucc                                                         14


<210> 15564
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15564
gguaaguucu guc                                                          13


<210> 15565
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15565
gguaaguucu gt                                                           12


<210> 15566
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15566
gguaaguucu g                                                            11


<210> 15567
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15567
gguaaguuct                                                              10


<210> 15568
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15568
gguaaguuc                                                                9


<210> 15569
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15569
gguaagut                                                                 8


<210> 15570
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15570
cgguaaguuc uguccaagcc                                                   20


<210> 15571
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15571
cgguaaguuc uguccaagc                                                    19


<210> 15572
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15572
cgguaaguuc uguccaag                                                     18


<210> 15573
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15573
cgguaaguuc uguccaa                                                      17


<210> 15574
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15574
cgguaaguuc ugucca                                                       16


<210> 15575
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15575
cgguaaguuc ugucc                                                        15


<210> 15576
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15576
cgguaaguuc uguc                                                         14


<210> 15577
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15577
cgguaaguuc ugt                                                          13


<210> 15578
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15578
cgguaaguuc ug                                                           12


<210> 15579
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15579
cgguaaguuc t                                                            11


<210> 15580
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15580
cgguaaguuc                                                              10


<210> 15581
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15581
cgguaagut                                                                9


<210> 15582
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15582
cgguaagt                                                                 8


<210> 15583
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15583
ucgguaaguu cuguccaagc                                                   20


<210> 15584
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15584
ucgguaaguu cuguccaag                                                    19


<210> 15585
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15585
ucgguaaguu cuguccaa                                                     18


<210> 15586
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15586
ucgguaaguu cugucca                                                      17


<210> 15587
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15587
ucgguaaguu cugucc                                                       16


<210> 15588
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15588
ucgguaaguu cuguc                                                        15


<210> 15589
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15589
ucgguaaguu cugt                                                         14


<210> 15590
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15590
ucgguaaguu cug                                                          13


<210> 15591
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15591
ucgguaaguu ct                                                           12


<210> 15592
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15592
ucgguaaguu c                                                            11


<210> 15593
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15593
ucgguaagut                                                              10


<210> 15594
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15594
ucgguaagt                                                                9


<210> 15595
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15595
gucgguaagu ucuguccaag                                                   20


<210> 15596
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15596
gucgguaagu ucuguccaa                                                    19


<210> 15597
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15597
gucgguaagu ucugucca                                                     18


<210> 15598
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15598
gucgguaagu ucugucc                                                      17


<210> 15599
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15599
gucgguaagu ucuguc                                                       16


<210> 15600
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15600
gucgguaagu ucugt                                                        15


<210> 15601
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15601
gucgguaagu ucug                                                         14


<210> 15602
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15602
gucgguaagu uct                                                          13


<210> 15603
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15603
gucgguaagu uc                                                           12


<210> 15604
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15604
gucgguaagu t                                                            11


<210> 15605
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15605
gucgguaagt                                                              10


<210> 15606
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15606
agucgguaag uucuguccaa                                                   20


<210> 15607
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15607
agucgguaag uucugucca                                                    19


<210> 15608
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15608
agucgguaag uucuguc                                                      17


<210> 15609
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15609
agucgguaag uucugt                                                       16


<210> 15610
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15610
agucgguaag uucug                                                        15


<210> 15611
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15611
agucgguaag uuct                                                         14


<210> 15612
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15612
agucgguaag uuc                                                          13


<210> 15613
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15613
agucgguaag ut                                                           12


<210> 15614
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15614
agucgguaag t                                                            11


<210> 15615
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15615
cagucgguaa guucugucca                                                   20


<210> 15616
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15616
cagucgguaa guucugucc                                                    19


<210> 15617
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15617
cagucgguaa guucuguc                                                     18


<210> 15618
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15618
cagucgguaa guucugt                                                      17


<210> 15619
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15619
cagucgguaa guucug                                                       16


<210> 15620
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15620
cagucgguaa guuct                                                        15


<210> 15621
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15621
cagucgguaa guuc                                                         14


<210> 15622
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15622
cagucgguaa gut                                                          13


<210> 15623
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15623
cagucgguaa gt                                                           12


<210> 15624
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15624
ccagucggua aguucugucc                                                   20


<210> 15625
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15625
ccagucggua aguucuguc                                                    19


<210> 15626
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15626
ccagucggua aguucugt                                                     18


<210> 15627
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15627
ccagucggua aguucug                                                      17


<210> 15628
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15628
ccagucggua aguuct                                                       16


<210> 15629
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15629
ccagucggua aguuc                                                        15


<210> 15630
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15630
ccagucggua agut                                                         14


<210> 15631
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15631
ccagucggua agt                                                          13


<210> 15632
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15632
gccagucggu aaguucuguc                                                   20


<210> 15633
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15633
gccagucggu aaguucugt                                                    19


<210> 15634
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15634
gccagucggu aaguucug                                                     18


<210> 15635
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15635
gccagucggu aaguuct                                                      17


<210> 15636
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15636
gccagucggu aaguuc                                                       16


<210> 15637
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15637
gccagucggu aagut                                                        15


<210> 15638
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15638
gccagucggu aagt                                                         14


<210> 15639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15639
ucaaggaaga uggcauuuct                                                   20


<210> 15640
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15640
ucaaggaaga uggcauuucu ag                                                22


<210> 15641
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15641
ucaaggaaga uggcat                                                       16


<210> 15642
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15642
gaagauggca uuuct                                                        15


<210> 15643
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15643
ucaaggaaga uggcauuucu a                                                 21


<210> 15644
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15644
ucaaggaaga uggcauuuc                                                    19


<210> 15645
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15645
ucaaggaaga uggcauut                                                     18


<210> 15646
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15646
ucaaggaaga uggcaut                                                      17


<210> 15647
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15647
ucaaggaaga uggca                                                        15


<210> 15648
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15648
ucaaggaaga uggc                                                         14


<210> 15649
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15649
ucaaggaaga ugg                                                          13


<210> 15650
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15650
ucaaggaaga ug                                                           12


<210> 15651
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15651
ucaaggaaga t                                                            11


<210> 15652
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15652
ucaaggaaga                                                              10


<210> 15653
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15653
ucaaggaag                                                                9


<210> 15654
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15654
caaggaagau ggcauuucua g                                                 21


<210> 15655
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15655
caaggaagau ggcauuucua                                                   20


<210> 15656
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15656
caaggaagau ggcauuuct                                                    19


<210> 15657
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15657
caaggaagau ggcauuuc                                                     18


<210> 15658
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15658
caaggaagau ggcauut                                                      17


<210> 15659
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15659
caaggaagau ggcaut                                                       16


<210> 15660
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15660
caaggaagau ggcat                                                        15


<210> 15661
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15661
caaggaagau ggca                                                         14


<210> 15662
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15662
caaggaagau ggc                                                          13


<210> 15663
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15663
caaggaagau gg                                                           12


<210> 15664
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15664
caaggaagau g                                                            11


<210> 15665
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15665
caaggaagat                                                              10


<210> 15666
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15666
caaggaaga                                                                9


<210> 15667
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15667
caaggaag                                                                 8


<210> 15668
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15668
aaggaagaug gcauuucuag                                                   20


<210> 15669
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15669
aaggaagaug gcauuucua                                                    19


<210> 15670
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15670
aaggaagaug gcauuuct                                                     18


<210> 15671
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15671
aaggaagaug gcauuuc                                                      17


<210> 15672
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15672
aaggaagaug gcauut                                                       16


<210> 15673
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15673
aaggaagaug gcaut                                                        15


<210> 15674
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15674
aaggaagaug gcat                                                         14


<210> 15675
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15675
aaggaagaug gca                                                          13


<210> 15676
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15676
aaggaagaug gc                                                           12


<210> 15677
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15677
aaggaagaug g                                                            11


<210> 15678
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15678
aaggaagaug                                                              10


<210> 15679
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15679
aaggaagat                                                                9


<210> 15680
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15680
aaggaaga                                                                 8


<210> 15681
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15681
aggaagaugg cauuucuag                                                    19


<210> 15682
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15682
aggaagaugg cauuucua                                                     18


<210> 15683
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15683
aggaagaugg cauuuct                                                      17


<210> 15684
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15684
aggaagaugg cauuuc                                                       16


<210> 15685
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15685
aggaagaugg cauut                                                        15


<210> 15686
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15686
aggaagaugg caut                                                         14


<210> 15687
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15687
aggaagaugg cat                                                          13


<210> 15688
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15688
aggaagaugg ca                                                           12


<210> 15689
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15689
aggaagaugg                                                              10


<210> 15690
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15690
aggaagaug                                                                9


<210> 15691
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15691
aggaagat                                                                 8


<210> 15692
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15692
ggaagauggc auuucuag                                                     18


<210> 15693
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15693
ggaagauggc auuucua                                                      17


<210> 15694
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15694
ggaagauggc auuuct                                                       16


<210> 15695
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15695
ggaagauggc auuuc                                                        15


<210> 15696
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15696
ggaagauggc auut                                                         14


<210> 15697
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15697
ggaagauggc aut                                                          13


<210> 15698
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15698
ggaagauggc at                                                           12


<210> 15699
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15699
ggaagauggc a                                                            11


<210> 15700
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15700
ggaagauggc                                                              10


<210> 15701
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15701
ggaagaug                                                                 8


<210> 15702
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15702
gaagauggca uuucuag                                                      17


<210> 15703
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15703
gaagauggca uuucua                                                       16


<210> 15704
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15704
gaagauggca uuuc                                                         14


<210> 15705
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15705
gaagauggca uut                                                          13


<210> 15706
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15706
gaagauggca ut                                                           12


<210> 15707
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15707
gaagauggca t                                                            11


<210> 15708
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15708
gaagauggca                                                              10


<210> 15709
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15709
gaagauggc                                                                9


<210> 15710
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15710
gaagaugg                                                                 8


<210> 15711
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15711
aagauggcau uucuag                                                       16


<210> 15712
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15712
aagauggcau uucua                                                        15


<210> 15713
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15713
aagauggcau uuct                                                         14


<210> 15714
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15714
aagauggcau uuc                                                          13


<210> 15715
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15715
aagauggcau ut                                                           12


<210> 15716
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15716
aagauggcau t                                                            11


<210> 15717
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15717
aagauggcat                                                              10


<210> 15718
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15718
aagauggca                                                                9


<210> 15719
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15719
aagauggc                                                                 8


<210> 15720
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15720
agauggcauu ucuag                                                        15


<210> 15721
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15721
agauggcauu ucua                                                         14


<210> 15722
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15722
agauggcauu uct                                                          13


<210> 15723
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15723
agauggcauu uc                                                           12


<210> 15724
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15724
agauggcauu t                                                            11


<210> 15725
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15725
agauggcaut                                                              10


<210> 15726
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15726
agauggcat                                                                9


<210> 15727
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15727
agauggca                                                                 8


<210> 15728
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15728
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 15729
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15729
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 15730
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15730
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 15731
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15731
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 15732
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15732
cuccaacauc aaggaagaug gcauut                                            26


<210> 15733
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15733
cuccaacauc aaggaagaug gcaut                                             25


<210> 15734
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15734
cuccaacauc aaggaagaug gcat                                              24


<210> 15735
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15735
cuccaacauc aaggaagaug gca                                               23


<210> 15736
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15736
cuccaacauc aaggaagaug gc                                                22


<210> 15737
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15737
cuccaacauc aaggaagaug g                                                 21


<210> 15738
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15738
cuccaacauc aaggaagaug                                                   20


<210> 15739
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15739
cuccaacauc aaggaagat                                                    19


<210> 15740
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15740
cuccaacauc aaggaaga                                                     18


<210> 15741
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15741
cuccaacauc aaggaag                                                      17


<210> 15742
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15742
uccaacauca aggaagaugg cauuucuag                                         29


<210> 15743
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15743
uccaacauca aggaagaugg cauuucua                                          28


<210> 15744
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15744
uccaacauca aggaagaugg cauuuct                                           27


<210> 15745
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15745
uccaacauca aggaagaugg cauuuc                                            26


<210> 15746
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15746
uccaacauca aggaagaugg cauut                                             25


<210> 15747
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15747
uccaacauca aggaagaugg caut                                              24


<210> 15748
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15748
uccaacauca aggaagaugg cat                                               23


<210> 15749
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15749
uccaacauca aggaagaugg ca                                                22


<210> 15750
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15750
uccaacauca aggaagaugg c                                                 21


<210> 15751
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15751
uccaacauca aggaagaugg                                                   20


<210> 15752
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15752
uccaacauca aggaagaug                                                    19


<210> 15753
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15753
uccaacauca aggaagat                                                     18


<210> 15754
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15754
uccaacauca aggaaga                                                      17


<210> 15755
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15755
uccaacauca aggaag                                                       16


<210> 15756
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15756
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 15757
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15757
ccaacaucaa ggaagauggc auuucua                                           27


<210> 15758
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15758
ccaacaucaa ggaagauggc auuuct                                            26


<210> 15759
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15759
ccaacaucaa ggaagauggc auuuc                                             25


<210> 15760
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15760
ccaacaucaa ggaagauggc auut                                              24


<210> 15761
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15761
ccaacaucaa ggaagauggc aut                                               23


<210> 15762
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15762
ccaacaucaa ggaagauggc at                                                22


<210> 15763
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15763
ccaacaucaa ggaagauggc a                                                 21


<210> 15764
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15764
ccaacaucaa ggaagauggc                                                   20


<210> 15765
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15765
ccaacaucaa ggaagaugg                                                    19


<210> 15766
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15766
ccaacaucaa ggaagaug                                                     18


<210> 15767
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15767
ccaacaucaa ggaagat                                                      17


<210> 15768
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15768
ccaacaucaa ggaaga                                                       16


<210> 15769
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15769
ccaacaucaa ggaag                                                        15


<210> 15770
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15770
caacaucaag gaagauggca uuucuag                                           27


<210> 15771
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15771
caacaucaag gaagauggca uuucua                                            26


<210> 15772
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15772
caacaucaag gaagauggca uuuct                                             25


<210> 15773
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15773
caacaucaag gaagauggca uuuc                                              24


<210> 15774
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15774
caacaucaag gaagauggca uut                                               23


<210> 15775
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15775
caacaucaag gaagauggca ut                                                22


<210> 15776
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15776
caacaucaag gaagauggca t                                                 21


<210> 15777
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15777
caacaucaag gaagauggca                                                   20


<210> 15778
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15778
caacaucaag gaagauggc                                                    19


<210> 15779
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15779
caacaucaag gaagaugg                                                     18


<210> 15780
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15780
caacaucaag gaagaug                                                      17


<210> 15781
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15781
caacaucaag gaagat                                                       16


<210> 15782
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15782
caacaucaag gaaga                                                        15


<210> 15783
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15783
caacaucaag gaag                                                         14


<210> 15784
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15784
aacaucaagg aagauggcau uucuag                                            26


<210> 15785
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15785
aacaucaagg aagauggcau uucua                                             25


<210> 15786
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15786
aacaucaagg aagauggcau uuct                                              24


<210> 15787
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15787
aacaucaagg aagauggcau uuc                                               23


<210> 15788
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15788
aacaucaagg aagauggcau ut                                                22


<210> 15789
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15789
aacaucaagg aagauggcau t                                                 21


<210> 15790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15790
aacaucaagg aagauggcat                                                   20


<210> 15791
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15791
aacaucaagg aagauggca                                                    19


<210> 15792
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15792
aacaucaagg aagauggc                                                     18


<210> 15793
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15793
aacaucaagg aagaugg                                                      17


<210> 15794
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15794
aacaucaagg aagaug                                                       16


<210> 15795
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15795
aacaucaagg aagat                                                        15


<210> 15796
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15796
aacaucaagg aaga                                                         14


<210> 15797
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15797
aacaucaagg aag                                                          13


<210> 15798
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15798
acaucaagga agauggcauu ucuag                                             25


<210> 15799
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15799
acaucaagga agauggcauu ucua                                              24


<210> 15800
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15800
acaucaagga agauggcauu uct                                               23


<210> 15801
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15801
acaucaagga agauggcauu uc                                                22


<210> 15802
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15802
acaucaagga agauggcauu t                                                 21


<210> 15803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15803
acaucaagga agauggcaut                                                   20


<210> 15804
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15804
acaucaagga agauggcat                                                    19


<210> 15805
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15805
acaucaagga agauggca                                                     18


<210> 15806
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15806
acaucaagga agauggc                                                      17


<210> 15807
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15807
acaucaagga agaugg                                                       16


<210> 15808
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15808
acaucaagga agaug                                                        15


<210> 15809
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15809
acaucaagga agat                                                         14


<210> 15810
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15810
acaucaagga aga                                                          13


<210> 15811
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15811
acaucaagga ag                                                           12


<210> 15812
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15812
caucaaggaa gauggcauuu cuag                                              24


<210> 15813
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15813
caucaaggaa gauggcauuu cua                                               23


<210> 15814
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15814
caucaaggaa gauggcauuu ct                                                22


<210> 15815
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15815
caucaaggaa gauggcauuu c                                                 21


<210> 15816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15816
caucaaggaa gauggcauut                                                   20


<210> 15817
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15817
caucaaggaa gauggcaut                                                    19


<210> 15818
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15818
caucaaggaa gauggcat                                                     18


<210> 15819
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15819
caucaaggaa gauggca                                                      17


<210> 15820
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15820
caucaaggaa gauggc                                                       16


<210> 15821
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15821
caucaaggaa gaugg                                                        15


<210> 15822
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15822
caucaaggaa gaug                                                         14


<210> 15823
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15823
caucaaggaa gat                                                          13


<210> 15824
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15824
caucaaggaa ga                                                           12


<210> 15825
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15825
caucaaggaa g                                                            11


<210> 15826
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15826
aucaaggaag auggcauuuc uag                                               23


<210> 15827
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15827
aucaaggaag auggcauuuc ua                                                22


<210> 15828
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15828
aucaaggaag auggcauuuc t                                                 21


<210> 15829
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15829
aucaaggaag auggcauuuc                                                   20


<210> 15830
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15830
aucaaggaag auggcauut                                                    19


<210> 15831
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15831
aucaaggaag auggcaut                                                     18


<210> 15832
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15832
aucaaggaag auggcat                                                      17


<210> 15833
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15833
aucaaggaag auggca                                                       16


<210> 15834
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15834
aucaaggaag auggc                                                        15


<210> 15835
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15835
aucaaggaag augg                                                         14


<210> 15836
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15836
aucaaggaag aug                                                          13


<210> 15837
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15837
aucaaggaag at                                                           12


<210> 15838
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15838
aucaaggaag a                                                            11


<210> 15839
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15839
aucaaggaag                                                              10


<210> 15840
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15840
ccagagcagg uaccuccaac auc                                               23


<210> 15841
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15841
ccagagcagg uaccucca                                                     18


<210> 15842
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15842
ccucugugau uuuauaacuu gat                                               23


<210> 15843
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15843
ucacccacca ucaccct                                                      17


<210> 15844
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15844
ugauauccuc aaggucaccc                                                   20


<210> 15845
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15845
cugcuugaug aucaucucgu ug                                                22


<210> 15846
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15846
cugcuugaug aucaucuc                                                     18


<210> 15847
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15847
guuuccuuag uaaccacag                                                    19


<210> 15848
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 15848
guuuccuuag uaaccac                                                      17


<210> 15849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 15849
tcaaggaaga uggcauuuct                                                   20


<210> 15850
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 15850
tcaaggaaga uggcauuucu ag                                                22


<210> 15851
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 15851
gguaaguucu guccaagc                                                     18


<210> 15852
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 15852
guaaguucug uccaagcc                                                     18


<210> 15853
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 15853
agucgguaag uucugucc                                                     18


<210> 15854
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15854
cuguccaagc ccgguuga                                                     18


<210> 15855
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 15855
taaguucugu ccaag                                                        15


<210> 15856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 15856
tucuguccaa gcccgguuga                                                   20


<210> 15857
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15857
tucuguccaa gcccgguug                                                    19


<210> 15858
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15858
tucuguccaa gcccggut                                                     18


<210> 15859
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15859
tucuguccaa gcccggt                                                      17


<210> 15860
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 15860
tucuguccaa gcccgg                                                       16


<210> 15861
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 15861
tucuguccaa gcccg                                                        15


<210> 15862
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 15862
tucuguccaa gccc                                                         14


<210> 15863
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 15863
tucuguccaa gcc                                                          13


<210> 15864
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 15864
tucuguccaa gc                                                           12


<210> 15865
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 15865
tucuguccaa g                                                            11


<210> 15866
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 15866
tucuguccaa                                                              10


<210> 15867
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 15867
tucugucca                                                                9


<210> 15868
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 15868
tucugucc                                                                 8


<210> 15869
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15869
tcuguccaag cccgguuga                                                    19


<210> 15870
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15870
tcuguccaag cccgguug                                                     18


<210> 15871
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15871
tcuguccaag cccggut                                                      17


<210> 15872
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 15872
tcuguccaag cccggt                                                       16


<210> 15873
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 15873
tcuguccaag cccgg                                                        15


<210> 15874
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 15874
tcuguccaag cccg                                                         14


<210> 15875
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 15875
tcuguccaag ccc                                                          13


<210> 15876
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 15876
tcuguccaag cc                                                           12


<210> 15877
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 15877
tcuguccaag c                                                            11


<210> 15878
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 15878
tcuguccaag                                                              10


<210> 15879
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 15879
tcuguccaa                                                                9


<210> 15880
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 15880
tcugucca                                                                 8


<210> 15881
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15881
cuguccaagc ccgguug                                                      17


<210> 15882
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 15882
cuguccaagc ccggut                                                       16


<210> 15883
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 15883
cuguccaagc ccggt                                                        15


<210> 15884
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 15884
cuguccaagc ccgg                                                         14


<210> 15885
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 15885
cuguccaagc ccg                                                          13


<210> 15886
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 15886
cuguccaagc cc                                                           12


<210> 15887
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 15887
cuguccaagc c                                                            11


<210> 15888
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 15888
cuguccaagc                                                              10


<210> 15889
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 15889
cuguccaag                                                                9


<210> 15890
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 15890
cuguccaa                                                                 8


<210> 15891
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 15891
guucugucca agcccgguug                                                   20


<210> 15892
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15892
guucugucca agcccggut                                                    19


<210> 15893
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15893
guucugucca agcccggt                                                     18


<210> 15894
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15894
guucugucca agcccgg                                                      17


<210> 15895
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 15895
guucugucca agcccg                                                       16


<210> 15896
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 15896
guucugucca agccc                                                        15


<210> 15897
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 15897
guucugucca agcc                                                         14


<210> 15898
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 15898
guucugucca agc                                                          13


<210> 15899
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 15899
guucugucca ag                                                           12


<210> 15900
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 15900
guucugucca a                                                            11


<210> 15901
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 15901
guucugucca                                                              10


<210> 15902
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 15902
guucugucc                                                                9


<210> 15903
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 15903
guucuguc                                                                 8


<210> 15904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 15904
aguucugucc aagcccggut                                                   20


<210> 15905
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15905
aguucugucc aagcccggt                                                    19


<210> 15906
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15906
aguucugucc aagcccgg                                                     18


<210> 15907
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15907
aguucugucc aagcccg                                                      17


<210> 15908
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 15908
aguucugucc aagccc                                                       16


<210> 15909
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 15909
aguucugucc aagcc                                                        15


<210> 15910
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 15910
aguucugucc aagc                                                         14


<210> 15911
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 15911
aguucugucc aag                                                          13


<210> 15912
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 15912
aguucugucc aa                                                           12


<210> 15913
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 15913
aguucugucc a                                                            11


<210> 15914
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 15914
aguucugucc                                                              10


<210> 15915
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 15915
aguucuguc                                                                9


<210> 15916
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 15916
aguucugt                                                                 8


<210> 15917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 15917
aaguucuguc caagcccggt                                                   20


<210> 15918
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15918
aaguucuguc caagcccgg                                                    19


<210> 15919
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15919
aaguucuguc caagcccg                                                     18


<210> 15920
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 15920
aaguucuguc caagccc                                                      17


<210> 15921
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 15921
aaguucuguc caagcc                                                       16


<210> 15922
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 15922
aaguucuguc caagc                                                        15


<210> 15923
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 15923
aaguucuguc caag                                                         14


<210> 15924
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 15924
aaguucuguc caa                                                          13


<210> 15925
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 15925
aaguucuguc ca                                                           12


<210> 15926
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 15926
aaguucuguc c                                                            11


<210> 15927
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 15927
aaguucuguc                                                              10


<210> 15928
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 15928
aaguucugt                                                                9


<210> 15929
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 15929
aaguucug                                                                 8


<210> 15930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 15930
taaguucugu ccaagcccgg                                                   20


<210> 15931
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15931
taaguucugu ccaagcccg                                                    19


<210> 15932
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 15932
taaguucugu ccaagccc                                                     18


<210> 15933
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 15933
taaguucugu ccaagcc                                                      17


<210> 15934
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 15934
taaguucugu ccaagc                                                       16


<210> 15935
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 15935
taaguucugu ccaa                                                         14


<210> 15936
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 15936
taaguucugu cca                                                          13


<210> 15937
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 15937
taaguucugu cc                                                           12


<210> 15938
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 15938
taaguucugu c                                                            11


<210> 15939
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 15939
taaguucugt                                                              10


<210> 15940
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 15940
taaguucug                                                                9


<210> 15941
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 15941
taaguuct                                                                 8


<210> 15942
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 15942
guaaguucug uccaagcccg                                                   20


<210> 15943
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 15943
guaaguucug uccaagccc                                                    19


<210> 15944
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 15944
guaaguucug uccaagc                                                      17


<210> 15945
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 15945
guaaguucug uccaag                                                       16


<210> 15946
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 15946
guaaguucug uccaa                                                        15


<210> 15947
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 15947
guaaguucug ucca                                                         14


<210> 15948
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 15948
guaaguucug ucc                                                          13


<210> 15949
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 15949
guaaguucug uc                                                           12


<210> 15950
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 15950
guaaguucug t                                                            11


<210> 15951
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 15951
guaaguucug                                                              10


<210> 15952
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 15952
guaaguuct                                                                9


<210> 15953
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 15953
guaaguuc                                                                 8


<210> 15954
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 15954
gguaaguucu guccaagccc                                                   20


<210> 15955
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 15955
gguaaguucu guccaagcc                                                    19


<210> 15956
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15956
gguaaguucu guccaag                                                      17


<210> 15957
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 15957
gguaaguucu guccaa                                                       16


<210> 15958
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 15958
gguaaguucu gucca                                                        15


<210> 15959
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 15959
gguaaguucu gucc                                                         14


<210> 15960
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 15960
gguaaguucu guc                                                          13


<210> 15961
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 15961
gguaaguucu gt                                                           12


<210> 15962
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 15962
gguaaguucu g                                                            11


<210> 15963
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 15963
gguaaguuct                                                              10


<210> 15964
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 15964
gguaaguuc                                                                9


<210> 15965
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 15965
gguaagut                                                                 8


<210> 15966
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 15966
cgguaaguuc uguccaagcc                                                   20


<210> 15967
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 15967
cgguaaguuc uguccaagc                                                    19


<210> 15968
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15968
cgguaaguuc uguccaag                                                     18


<210> 15969
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15969
cgguaaguuc uguccaa                                                      17


<210> 15970
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 15970
cgguaaguuc ugucca                                                       16


<210> 15971
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 15971
cgguaaguuc ugucc                                                        15


<210> 15972
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 15972
cgguaaguuc uguc                                                         14


<210> 15973
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 15973
cgguaaguuc ugt                                                          13


<210> 15974
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 15974
cgguaaguuc ug                                                           12


<210> 15975
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 15975
cgguaaguuc t                                                            11


<210> 15976
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 15976
cgguaaguuc                                                              10


<210> 15977
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 15977
cgguaagut                                                                9


<210> 15978
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 15978
cgguaagt                                                                 8


<210> 15979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 15979
tcgguaaguu cuguccaagc                                                   20


<210> 15980
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15980
tcgguaaguu cuguccaag                                                    19


<210> 15981
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15981
tcgguaaguu cuguccaa                                                     18


<210> 15982
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 15982
tcgguaaguu cugucca                                                      17


<210> 15983
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 15983
tcgguaaguu cugucc                                                       16


<210> 15984
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 15984
tcgguaaguu cuguc                                                        15


<210> 15985
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 15985
tcgguaaguu cugt                                                         14


<210> 15986
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 15986
tcgguaaguu cug                                                          13


<210> 15987
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 15987
tcgguaaguu ct                                                           12


<210> 15988
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 15988
tcgguaaguu c                                                            11


<210> 15989
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 15989
tcgguaagut                                                              10


<210> 15990
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 15990
tcgguaagt                                                                9


<210> 15991
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 15991
gucgguaagu ucuguccaag                                                   20


<210> 15992
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 15992
gucgguaagu ucuguccaa                                                    19


<210> 15993
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 15993
gucgguaagu ucugucca                                                     18


<210> 15994
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 15994
gucgguaagu ucugucc                                                      17


<210> 15995
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 15995
gucgguaagu ucuguc                                                       16


<210> 15996
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 15996
gucgguaagu ucugt                                                        15


<210> 15997
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 15997
gucgguaagu ucug                                                         14


<210> 15998
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 15998
gucgguaagu uct                                                          13


<210> 15999
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 15999
gucgguaagu uc                                                           12


<210> 16000
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16000
gucgguaagu t                                                            11


<210> 16001
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16001
gucgguaagt                                                              10


<210> 16002
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16002
agucgguaag uucuguccaa                                                   20


<210> 16003
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16003
agucgguaag uucugucca                                                    19


<210> 16004
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16004
agucgguaag uucuguc                                                      17


<210> 16005
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16005
agucgguaag uucugt                                                       16


<210> 16006
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16006
agucgguaag uucug                                                        15


<210> 16007
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16007
agucgguaag uuct                                                         14


<210> 16008
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 16008
agucgguaag uuc                                                          13


<210> 16009
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16009
agucgguaag ut                                                           12


<210> 16010
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16010
agucgguaag t                                                            11


<210> 16011
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16011
cagucgguaa guucugucca                                                   20


<210> 16012
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 16012
cagucgguaa guucugucc                                                    19


<210> 16013
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16013
cagucgguaa guucuguc                                                     18


<210> 16014
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16014
cagucgguaa guucugt                                                      17


<210> 16015
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16015
cagucgguaa guucug                                                       16


<210> 16016
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16016
cagucgguaa guuct                                                        15


<210> 16017
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 16017
cagucgguaa guuc                                                         14


<210> 16018
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16018
cagucgguaa gut                                                          13


<210> 16019
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16019
cagucgguaa gt                                                           12


<210> 16020
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16020
ccagucggua aguucugucc                                                   20


<210> 16021
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 16021
ccagucggua aguucuguc                                                    19


<210> 16022
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16022
ccagucggua aguucugt                                                     18


<210> 16023
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16023
ccagucggua aguucug                                                      17


<210> 16024
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16024
ccagucggua aguuct                                                       16


<210> 16025
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 16025
ccagucggua aguuc                                                        15


<210> 16026
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16026
ccagucggua agut                                                         14


<210> 16027
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16027
ccagucggua agt                                                          13


<210> 16028
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16028
gccagucggu aaguucuguc                                                   20


<210> 16029
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16029
gccagucggu aaguucugt                                                    19


<210> 16030
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16030
gccagucggu aaguucug                                                     18


<210> 16031
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16031
gccagucggu aaguuct                                                      17


<210> 16032
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 16032
gccagucggu aaguuc                                                       16


<210> 16033
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16033
gccagucggu aagut                                                        15


<210> 16034
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16034
gccagucggu aagt                                                         14


<210> 16035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16035
tcaaggaaga uggcauuuct                                                   20


<210> 16036
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16036
tcaaggaaga uggcauuucu ag                                                22


<210> 16037
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16037
tcaaggaaga uggcat                                                       16


<210> 16038
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16038
gaagauggca uuuct                                                        15


<210> 16039
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16039
tcaaggaaga uggcauuucu a                                                 21


<210> 16040
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 16040
tcaaggaaga uggcauuuc                                                    19


<210> 16041
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16041
tcaaggaaga uggcauut                                                     18


<210> 16042
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16042
tcaaggaaga uggcaut                                                      17


<210> 16043
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16043
tcaaggaaga uggca                                                        15


<210> 16044
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 16044
tcaaggaaga uggc                                                         14


<210> 16045
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16045
tcaaggaaga ugg                                                          13


<210> 16046
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16046
tcaaggaaga ug                                                           12


<210> 16047
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16047
tcaaggaaga t                                                            11


<210> 16048
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16048
tcaaggaaga                                                              10


<210> 16049
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16049
tcaaggaag                                                                9


<210> 16050
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16050
caaggaagau ggcauuucua g                                                 21


<210> 16051
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16051
caaggaagau ggcauuucua                                                   20


<210> 16052
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16052
caaggaagau ggcauuuct                                                    19


<210> 16053
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16053
caaggaagau ggcauuuc                                                     18


<210> 16054
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16054
caaggaagau ggcauut                                                      17


<210> 16055
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16055
caaggaagau ggcaut                                                       16


<210> 16056
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16056
caaggaagau ggcat                                                        15


<210> 16057
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16057
caaggaagau ggca                                                         14


<210> 16058
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 16058
caaggaagau ggc                                                          13


<210> 16059
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16059
caaggaagau gg                                                           12


<210> 16060
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16060
caaggaagau g                                                            11


<210> 16061
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16061
caaggaagat                                                              10


<210> 16062
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16062
caaggaaga                                                                9


<210> 16063
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16063
caaggaag                                                                 8


<210> 16064
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16064
aaggaagaug gcauuucuag                                                   20


<210> 16065
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16065
aaggaagaug gcauuucua                                                    19


<210> 16066
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16066
aaggaagaug gcauuuct                                                     18


<210> 16067
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16067
aaggaagaug gcauuuc                                                      17


<210> 16068
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16068
aaggaagaug gcauut                                                       16


<210> 16069
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16069
aaggaagaug gcaut                                                        15


<210> 16070
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16070
aaggaagaug gcat                                                         14


<210> 16071
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16071
aaggaagaug gca                                                          13


<210> 16072
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 16072
aaggaagaug gc                                                           12


<210> 16073
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16073
aaggaagaug g                                                            11


<210> 16074
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16074
aaggaagaug                                                              10


<210> 16075
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16075
aaggaagat                                                                9


<210> 16076
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16076
aaggaaga                                                                 8


<210> 16077
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16077
aggaagaugg cauuucuag                                                    19


<210> 16078
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16078
aggaagaugg cauuucua                                                     18


<210> 16079
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16079
aggaagaugg cauuuct                                                      17


<210> 16080
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 16080
aggaagaugg cauuuc                                                       16


<210> 16081
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16081
aggaagaugg cauut                                                        15


<210> 16082
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16082
aggaagaugg caut                                                         14


<210> 16083
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16083
aggaagaugg cat                                                          13


<210> 16084
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16084
aggaagaugg ca                                                           12


<210> 16085
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16085
aggaagaugg                                                              10


<210> 16086
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16086
aggaagaug                                                                9


<210> 16087
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16087
aggaagat                                                                 8


<210> 16088
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16088
ggaagauggc auuucuag                                                     18


<210> 16089
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16089
ggaagauggc auuucua                                                      17


<210> 16090
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16090
ggaagauggc auuuct                                                       16


<210> 16091
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 16091
ggaagauggc auuuc                                                        15


<210> 16092
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16092
ggaagauggc auut                                                         14


<210> 16093
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16093
ggaagauggc aut                                                          13


<210> 16094
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16094
ggaagauggc at                                                           12


<210> 16095
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16095
ggaagauggc a                                                            11


<210> 16096
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 16096
ggaagauggc                                                              10


<210> 16097
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16097
ggaagaug                                                                 8


<210> 16098
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16098
gaagauggca uuucuag                                                      17


<210> 16099
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16099
gaagauggca uuucua                                                       16


<210> 16100
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 16100
gaagauggca uuuc                                                         14


<210> 16101
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16101
gaagauggca uut                                                          13


<210> 16102
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16102
gaagauggca ut                                                           12


<210> 16103
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16103
gaagauggca t                                                            11


<210> 16104
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16104
gaagauggca                                                              10


<210> 16105
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 16105
gaagauggc                                                                9


<210> 16106
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16106
gaagaugg                                                                 8


<210> 16107
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16107
aagauggcau uucuag                                                       16


<210> 16108
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16108
aagauggcau uucua                                                        15


<210> 16109
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16109
aagauggcau uuct                                                         14


<210> 16110
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 16110
aagauggcau uuc                                                          13


<210> 16111
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16111
aagauggcau ut                                                           12


<210> 16112
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16112
aagauggcau t                                                            11


<210> 16113
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16113
aagauggcat                                                              10


<210> 16114
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16114
aagauggca                                                                9


<210> 16115
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 16115
aagauggc                                                                 8


<210> 16116
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16116
agauggcauu ucuag                                                        15


<210> 16117
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16117
agauggcauu ucua                                                         14


<210> 16118
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16118
agauggcauu uct                                                          13


<210> 16119
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 16119
agauggcauu uc                                                           12


<210> 16120
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16120
agauggcauu t                                                            11


<210> 16121
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16121
agauggcaut                                                              10


<210> 16122
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16122
agauggcat                                                                9


<210> 16123
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16123
agauggca                                                                 8


<210> 16124
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 16124
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 16125
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 16125
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 16126
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 16126
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 16127
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<400> 16127
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 16128
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 16128
cuccaacauc aaggaagaug gcauut                                            26


<210> 16129
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 16129
cuccaacauc aaggaagaug gcaut                                             25


<210> 16130
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16130
cuccaacauc aaggaagaug gcat                                              24


<210> 16131
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16131
cuccaacauc aaggaagaug gca                                               23


<210> 16132
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 16132
cuccaacauc aaggaagaug gc                                                22


<210> 16133
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16133
cuccaacauc aaggaagaug g                                                 21


<210> 16134
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16134
cuccaacauc aaggaagaug                                                   20


<210> 16135
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16135
cuccaacauc aaggaagat                                                    19


<210> 16136
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16136
cuccaacauc aaggaaga                                                     18


<210> 16137
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16137
cuccaacauc aaggaag                                                      17


<210> 16138
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 16138
tccaacauca aggaagaugg cauuucuag                                         29


<210> 16139
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 16139
tccaacauca aggaagaugg cauuucua                                          28


<210> 16140
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 16140
tccaacauca aggaagaugg cauuuct                                           27


<210> 16141
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<400> 16141
tccaacauca aggaagaugg cauuuc                                            26


<210> 16142
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 16142
tccaacauca aggaagaugg cauut                                             25


<210> 16143
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16143
tccaacauca aggaagaugg caut                                              24


<210> 16144
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16144
tccaacauca aggaagaugg cat                                               23


<210> 16145
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16145
tccaacauca aggaagaugg ca                                                22


<210> 16146
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 16146
tccaacauca aggaagaugg c                                                 21


<210> 16147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16147
tccaacauca aggaagaugg                                                   20


<210> 16148
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16148
tccaacauca aggaagaug                                                    19


<210> 16149
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16149
tccaacauca aggaagat                                                     18


<210> 16150
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16150
tccaacauca aggaaga                                                      17


<210> 16151
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16151
tccaacauca aggaag                                                       16


<210> 16152
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 16152
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 16153
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 16153
ccaacaucaa ggaagauggc auuucua                                           27


<210> 16154
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 16154
ccaacaucaa ggaagauggc auuuct                                            26


<210> 16155
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<400> 16155
ccaacaucaa ggaagauggc auuuc                                             25


<210> 16156
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16156
ccaacaucaa ggaagauggc auut                                              24


<210> 16157
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16157
ccaacaucaa ggaagauggc aut                                               23


<210> 16158
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16158
ccaacaucaa ggaagauggc at                                                22


<210> 16159
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16159
ccaacaucaa ggaagauggc a                                                 21


<210> 16160
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16160
ccaacaucaa ggaagauggc                                                   20


<210> 16161
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16161
ccaacaucaa ggaagaugg                                                    19


<210> 16162
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16162
ccaacaucaa ggaagaug                                                     18


<210> 16163
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16163
ccaacaucaa ggaagat                                                      17


<210> 16164
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16164
ccaacaucaa ggaaga                                                       16


<210> 16165
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16165
ccaacaucaa ggaag                                                        15


<210> 16166
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 16166
caacaucaag gaagauggca uuucuag                                           27


<210> 16167
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 16167
caacaucaag gaagauggca uuucua                                            26


<210> 16168
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 16168
caacaucaag gaagauggca uuuct                                             25


<210> 16169
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<400> 16169
caacaucaag gaagauggca uuuc                                              24


<210> 16170
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16170
caacaucaag gaagauggca uut                                               23


<210> 16171
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16171
caacaucaag gaagauggca ut                                                22


<210> 16172
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16172
caacaucaag gaagauggca t                                                 21


<210> 16173
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16173
caacaucaag gaagauggca                                                   20


<210> 16174
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 16174
caacaucaag gaagauggc                                                    19


<210> 16175
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16175
caacaucaag gaagaugg                                                     18


<210> 16176
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16176
caacaucaag gaagaug                                                      17


<210> 16177
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16177
caacaucaag gaagat                                                       16


<210> 16178
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16178
caacaucaag gaaga                                                        15


<210> 16179
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16179
caacaucaag gaag                                                         14


<210> 16180
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 16180
aacaucaagg aagauggcau uucuag                                            26


<210> 16181
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 16181
aacaucaagg aagauggcau uucua                                             25


<210> 16182
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16182
aacaucaagg aagauggcau uuct                                              24


<210> 16183
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 16183
aacaucaagg aagauggcau uuc                                               23


<210> 16184
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16184
aacaucaagg aagauggcau ut                                                22


<210> 16185
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16185
aacaucaagg aagauggcau t                                                 21


<210> 16186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16186
aacaucaagg aagauggcat                                                   20


<210> 16187
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16187
aacaucaagg aagauggca                                                    19


<210> 16188
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16188
aacaucaagg aagauggc                                                     18


<210> 16189
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16189
aacaucaagg aagaugg                                                      17


<210> 16190
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16190
aacaucaagg aagaug                                                       16


<210> 16191
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16191
aacaucaagg aagat                                                        15


<210> 16192
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16192
aacaucaagg aaga                                                         14


<210> 16193
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16193
aacaucaagg aag                                                          13


<210> 16194
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 16194
acaucaagga agauggcauu ucuag                                             25


<210> 16195
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16195
acaucaagga agauggcauu ucua                                              24


<210> 16196
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16196
acaucaagga agauggcauu uct                                               23


<210> 16197
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 16197
acaucaagga agauggcauu uc                                                22


<210> 16198
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16198
acaucaagga agauggcauu t                                                 21


<210> 16199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16199
acaucaagga agauggcaut                                                   20


<210> 16200
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16200
acaucaagga agauggcat                                                    19


<210> 16201
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16201
acaucaagga agauggca                                                     18


<210> 16202
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16202
acaucaagga agauggc                                                      17


<210> 16203
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16203
acaucaagga agaugg                                                       16


<210> 16204
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16204
acaucaagga agaug                                                        15


<210> 16205
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16205
acaucaagga agat                                                         14


<210> 16206
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16206
acaucaagga aga                                                          13


<210> 16207
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16207
acaucaagga ag                                                           12


<210> 16208
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16208
caucaaggaa gauggcauuu cuag                                              24


<210> 16209
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16209
caucaaggaa gauggcauuu cua                                               23


<210> 16210
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16210
caucaaggaa gauggcauuu ct                                                22


<210> 16211
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 16211
caucaaggaa gauggcauuu c                                                 21


<210> 16212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16212
caucaaggaa gauggcauut                                                   20


<210> 16213
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16213
caucaaggaa gauggcaut                                                    19


<210> 16214
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16214
caucaaggaa gauggcat                                                     18


<210> 16215
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16215
caucaaggaa gauggca                                                      17


<210> 16216
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 16216
caucaaggaa gauggc                                                       16


<210> 16217
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16217
caucaaggaa gaugg                                                        15


<210> 16218
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16218
caucaaggaa gaug                                                         14


<210> 16219
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16219
caucaaggaa gat                                                          13


<210> 16220
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16220
caucaaggaa ga                                                           12


<210> 16221
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16221
caucaaggaa g                                                            11


<210> 16222
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16222
aucaaggaag auggcauuuc uag                                               23


<210> 16223
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16223
aucaaggaag auggcauuuc ua                                                22


<210> 16224
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16224
aucaaggaag auggcauuuc t                                                 21


<210> 16225
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16225
aucaaggaag auggcauuuc                                                   20


<210> 16226
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16226
aucaaggaag auggcauut                                                    19


<210> 16227
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16227
aucaaggaag auggcaut                                                     18


<210> 16228
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16228
aucaaggaag auggcat                                                      17


<210> 16229
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16229
aucaaggaag auggca                                                       16


<210> 16230
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 16230
aucaaggaag auggc                                                        15


<210> 16231
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16231
aucaaggaag augg                                                         14


<210> 16232
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16232
aucaaggaag aug                                                          13


<210> 16233
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16233
aucaaggaag at                                                           12


<210> 16234
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16234
aucaaggaag a                                                            11


<210> 16235
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16235
aucaaggaag                                                              10


<210> 16236
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 16236
ccagagcagg uaccuccaac auc                                               23


<210> 16237
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16237
ccagagcagg uaccucca                                                     18


<210> 16238
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16238
ccucugugau uuuauaacuu gat                                               23


<210> 16239
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16239
tcacccacca ucaccct                                                      17


<210> 16240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16240
tgauauccuc aaggucaccc                                                   20


<210> 16241
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16241
cugcuugaug aucaucucgu ug                                                22


<210> 16242
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16242
cugcuugaug aucaucuc                                                     18


<210> 16243
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16243
guuuccuuag uaaccacag                                                    19


<210> 16244
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16244
guuuccuuag uaaccac                                                      17


<210> 16245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16245
tcaaggaaga uggcauuuct                                                   20


<210> 16246
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16246
tcaaggaaga uggcauuucu ag                                                22


<210> 16247
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16247
gguaaguucu guccaagc                                                     18


<210> 16248
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16248
guaaguucug uccaagcc                                                     18


<210> 16249
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16249
agucgguaag uucugucc                                                     18


<210> 16250
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16250
cuguccaagc ccgguuga                                                     18


<210> 16251
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16251
taaguucugu ccaag                                                        15


<210> 16252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16252
tucuguccaa gcccgguuga                                                   20


<210> 16253
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16253
tucuguccaa gcccgguug                                                    19


<210> 16254
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16254
tucuguccaa gcccggut                                                     18


<210> 16255
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16255
tucuguccaa gcccggt                                                      17


<210> 16256
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16256
tucuguccaa gcccgg                                                       16


<210> 16257
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16257
tucuguccaa gcccg                                                        15


<210> 16258
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 16258
tucuguccaa gccc                                                         14


<210> 16259
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 16259
tucuguccaa gcc                                                          13


<210> 16260
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 16260
tucuguccaa gc                                                           12


<210> 16261
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16261
tucuguccaa g                                                            11


<210> 16262
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16262
tucuguccaa                                                              10


<210> 16263
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16263
tucugucca                                                                9


<210> 16264
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 16264
tucugucc                                                                 8


<210> 16265
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16265
tcuguccaag cccgguuga                                                    19


<210> 16266
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16266
tcuguccaag cccgguug                                                     18


<210> 16267
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16267
tcuguccaag cccggut                                                      17


<210> 16268
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16268
tcuguccaag cccggt                                                       16


<210> 16269
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16269
tcuguccaag cccgg                                                        15


<210> 16270
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16270
tcuguccaag cccg                                                         14


<210> 16271
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 16271
tcuguccaag ccc                                                          13


<210> 16272
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 16272
tcuguccaag cc                                                           12


<210> 16273
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 16273
tcuguccaag c                                                            11


<210> 16274
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16274
tcuguccaag                                                              10


<210> 16275
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16275
tcuguccaa                                                                9


<210> 16276
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16276
tcugucca                                                                 8


<210> 16277
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16277
cuguccaagc ccgguug                                                      17


<210> 16278
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16278
cuguccaagc ccggut                                                       16


<210> 16279
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16279
cuguccaagc ccggt                                                        15


<210> 16280
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16280
cuguccaagc ccgg                                                         14


<210> 16281
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16281
cuguccaagc ccg                                                          13


<210> 16282
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 16282
cuguccaagc cc                                                           12


<210> 16283
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 16283
cuguccaagc c                                                            11


<210> 16284
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 16284
cuguccaagc                                                              10


<210> 16285
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16285
cuguccaag                                                                9


<210> 16286
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16286
cuguccaa                                                                 8


<210> 16287
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16287
guucugucca agcccgguug                                                   20


<210> 16288
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16288
guucugucca agcccggut                                                    19


<210> 16289
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16289
guucugucca agcccggt                                                     18


<210> 16290
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16290
guucugucca agcccgg                                                      17


<210> 16291
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16291
guucugucca agcccg                                                       16


<210> 16292
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 16292
guucugucca agccc                                                        15


<210> 16293
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 16293
guucugucca agcc                                                         14


<210> 16294
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 16294
guucugucca agc                                                          13


<210> 16295
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16295
guucugucca ag                                                           12


<210> 16296
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16296
guucugucca a                                                            11


<210> 16297
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16297
guucugucca                                                              10


<210> 16298
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 16298
guucugucc                                                                9


<210> 16299
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 16299
guucuguc                                                                 8


<210> 16300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16300
aguucugucc aagcccggut                                                   20


<210> 16301
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16301
aguucugucc aagcccggt                                                    19


<210> 16302
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16302
aguucugucc aagcccgg                                                     18


<210> 16303
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16303
aguucugucc aagcccg                                                      17


<210> 16304
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 16304
aguucugucc aagccc                                                       16


<210> 16305
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 16305
aguucugucc aagcc                                                        15


<210> 16306
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 16306
aguucugucc aagc                                                         14


<210> 16307
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16307
aguucugucc aag                                                          13


<210> 16308
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16308
aguucugucc aa                                                           12


<210> 16309
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16309
aguucugucc a                                                            11


<210> 16310
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 16310
aguucugucc                                                              10


<210> 16311
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 16311
aguucuguc                                                                9


<210> 16312
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16312
aguucugt                                                                 8


<210> 16313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16313
aaguucuguc caagcccggt                                                   20


<210> 16314
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16314
aaguucuguc caagcccgg                                                    19


<210> 16315
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16315
aaguucuguc caagcccg                                                     18


<210> 16316
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16316
aaguucuguc caagccc                                                      17


<210> 16317
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 16317
aaguucuguc caagcc                                                       16


<210> 16318
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 16318
aaguucuguc caagc                                                        15


<210> 16319
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16319
aaguucuguc caag                                                         14


<210> 16320
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16320
aaguucuguc caa                                                          13


<210> 16321
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16321
aaguucuguc ca                                                           12


<210> 16322
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 16322
aaguucuguc c                                                            11


<210> 16323
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 16323
aaguucuguc                                                              10


<210> 16324
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16324
aaguucugt                                                                9


<210> 16325
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16325
aaguucug                                                                 8


<210> 16326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16326
taaguucugu ccaagcccgg                                                   20


<210> 16327
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16327
taaguucugu ccaagcccg                                                    19


<210> 16328
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16328
taaguucugu ccaagccc                                                     18


<210> 16329
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16329
taaguucugu ccaagcc                                                      17


<210> 16330
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 16330
taaguucugu ccaagc                                                       16


<210> 16331
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16331
taaguucugu ccaa                                                         14


<210> 16332
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16332
taaguucugu cca                                                          13


<210> 16333
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 16333
taaguucugu cc                                                           12


<210> 16334
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 16334
taaguucugu c                                                            11


<210> 16335
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16335
taaguucugt                                                              10


<210> 16336
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16336
taaguucug                                                                9


<210> 16337
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16337
taaguuct                                                                 8


<210> 16338
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16338
guaaguucug uccaagcccg                                                   20


<210> 16339
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 16339
guaaguucug uccaagccc                                                    19


<210> 16340
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16340
guaaguucug uccaagc                                                      17


<210> 16341
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16341
guaaguucug uccaag                                                       16


<210> 16342
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16342
guaaguucug uccaa                                                        15


<210> 16343
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16343
guaaguucug ucca                                                         14


<210> 16344
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 16344
guaaguucug ucc                                                          13


<210> 16345
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 16345
guaaguucug uc                                                           12


<210> 16346
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16346
guaaguucug t                                                            11


<210> 16347
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16347
guaaguucug                                                              10


<210> 16348
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16348
guaaguuct                                                                9


<210> 16349
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 16349
guaaguuc                                                                 8


<210> 16350
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16350
gguaaguucu guccaagccc                                                   20


<210> 16351
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 16351
gguaaguucu guccaagcc                                                    19


<210> 16352
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16352
gguaaguucu guccaag                                                      17


<210> 16353
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16353
gguaaguucu guccaa                                                       16


<210> 16354
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16354
gguaaguucu gucca                                                        15


<210> 16355
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 16355
gguaaguucu gucc                                                         14


<210> 16356
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 16356
gguaaguucu guc                                                          13


<210> 16357
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16357
gguaaguucu gt                                                           12


<210> 16358
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16358
gguaaguucu g                                                            11


<210> 16359
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16359
gguaaguuct                                                              10


<210> 16360
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 16360
gguaaguuc                                                                9


<210> 16361
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16361
gguaagut                                                                 8


<210> 16362
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16362
cgguaaguuc uguccaagcc                                                   20


<210> 16363
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 16363
cgguaaguuc uguccaagc                                                    19


<210> 16364
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16364
cgguaaguuc uguccaag                                                     18


<210> 16365
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16365
cgguaaguuc uguccaa                                                      17


<210> 16366
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16366
cgguaaguuc ugucca                                                       16


<210> 16367
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 16367
cgguaaguuc ugucc                                                        15


<210> 16368
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 16368
cgguaaguuc uguc                                                         14


<210> 16369
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16369
cgguaaguuc ugt                                                          13


<210> 16370
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16370
cgguaaguuc ug                                                           12


<210> 16371
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16371
cgguaaguuc t                                                            11


<210> 16372
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 16372
cgguaaguuc                                                              10


<210> 16373
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16373
cgguaagut                                                                9


<210> 16374
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16374
cgguaagt                                                                 8


<210> 16375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16375
tcgguaaguu cuguccaagc                                                   20


<210> 16376
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16376
tcgguaaguu cuguccaag                                                    19


<210> 16377
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16377
tcgguaaguu cuguccaa                                                     18


<210> 16378
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16378
tcgguaaguu cugucca                                                      17


<210> 16379
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 16379
tcgguaaguu cugucc                                                       16


<210> 16380
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 16380
tcgguaaguu cuguc                                                        15


<210> 16381
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16381
tcgguaaguu cugt                                                         14


<210> 16382
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16382
tcgguaaguu cug                                                          13


<210> 16383
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16383
tcgguaaguu ct                                                           12


<210> 16384
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 16384
tcgguaaguu c                                                            11


<210> 16385
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16385
tcgguaagut                                                              10


<210> 16386
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16386
tcgguaagt                                                                9


<210> 16387
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16387
gucgguaagu ucuguccaag                                                   20


<210> 16388
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16388
gucgguaagu ucuguccaa                                                    19


<210> 16389
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16389
gucgguaagu ucugucca                                                     18


<210> 16390
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16390
gucgguaagu ucugucc                                                      17


<210> 16391
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 16391
gucgguaagu ucuguc                                                       16


<210> 16392
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16392
gucgguaagu ucugt                                                        15


<210> 16393
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16393
gucgguaagu ucug                                                         14


<210> 16394
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16394
gucgguaagu uct                                                          13


<210> 16395
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 16395
gucgguaagu uc                                                           12


<210> 16396
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16396
gucgguaagu t                                                            11


<210> 16397
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16397
gucgguaagt                                                              10


<210> 16398
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16398
agucgguaag uucuguccaa                                                   20


<210> 16399
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16399
agucgguaag uucugucca                                                    19


<210> 16400
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16400
agucgguaag uucuguc                                                      17


<210> 16401
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16401
agucgguaag uucugt                                                       16


<210> 16402
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16402
agucgguaag uucug                                                        15


<210> 16403
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16403
agucgguaag uuct                                                         14


<210> 16404
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 16404
agucgguaag uuc                                                          13


<210> 16405
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16405
agucgguaag ut                                                           12


<210> 16406
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16406
agucgguaag t                                                            11


<210> 16407
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16407
cagucgguaa guucugucca                                                   20


<210> 16408
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 16408
cagucgguaa guucugucc                                                    19


<210> 16409
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16409
cagucgguaa guucuguc                                                     18


<210> 16410
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16410
cagucgguaa guucugt                                                      17


<210> 16411
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16411
cagucgguaa guucug                                                       16


<210> 16412
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16412
cagucgguaa guuct                                                        15


<210> 16413
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 16413
cagucgguaa guuc                                                         14


<210> 16414
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16414
cagucgguaa gut                                                          13


<210> 16415
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16415
cagucgguaa gt                                                           12


<210> 16416
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16416
ccagucggua aguucugucc                                                   20


<210> 16417
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 16417
ccagucggua aguucuguc                                                    19


<210> 16418
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16418
ccagucggua aguucugt                                                     18


<210> 16419
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16419
ccagucggua aguucug                                                      17


<210> 16420
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16420
ccagucggua aguuct                                                       16


<210> 16421
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 16421
ccagucggua aguuc                                                        15


<210> 16422
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16422
ccagucggua agut                                                         14


<210> 16423
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16423
ccagucggua agt                                                          13


<210> 16424
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16424
gccagucggu aaguucuguc                                                   20


<210> 16425
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16425
gccagucggu aaguucugt                                                    19


<210> 16426
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16426
gccagucggu aaguucug                                                     18


<210> 16427
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16427
gccagucggu aaguuct                                                      17


<210> 16428
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 16428
gccagucggu aaguuc                                                       16


<210> 16429
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16429
gccagucggu aagut                                                        15


<210> 16430
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16430
gccagucggu aagt                                                         14


<210> 16431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16431
tcaaggaaga uggcauuuct                                                   20


<210> 16432
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16432
tcaaggaaga uggcauuucu ag                                                22


<210> 16433
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16433
tcaaggaaga uggcat                                                       16


<210> 16434
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16434
gaagauggca uuuct                                                        15


<210> 16435
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16435
tcaaggaaga uggcauuucu a                                                 21


<210> 16436
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 16436
tcaaggaaga uggcauuuc                                                    19


<210> 16437
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16437
tcaaggaaga uggcauut                                                     18


<210> 16438
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16438
tcaaggaaga uggcaut                                                      17


<210> 16439
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16439
tcaaggaaga uggca                                                        15


<210> 16440
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 16440
tcaaggaaga uggc                                                         14


<210> 16441
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16441
tcaaggaaga ugg                                                          13


<210> 16442
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16442
tcaaggaaga ug                                                           12


<210> 16443
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16443
tcaaggaaga t                                                            11


<210> 16444
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16444
tcaaggaaga                                                              10


<210> 16445
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16445
tcaaggaag                                                                9


<210> 16446
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16446
caaggaagau ggcauuucua g                                                 21


<210> 16447
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16447
caaggaagau ggcauuucua                                                   20


<210> 16448
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16448
caaggaagau ggcauuuct                                                    19


<210> 16449
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16449
caaggaagau ggcauuuc                                                     18


<210> 16450
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16450
caaggaagau ggcauut                                                      17


<210> 16451
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16451
caaggaagau ggcaut                                                       16


<210> 16452
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16452
caaggaagau ggcat                                                        15


<210> 16453
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16453
caaggaagau ggca                                                         14


<210> 16454
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 16454
caaggaagau ggc                                                          13


<210> 16455
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16455
caaggaagau gg                                                           12


<210> 16456
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16456
caaggaagau g                                                            11


<210> 16457
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16457
caaggaagat                                                              10


<210> 16458
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16458
caaggaaga                                                                9


<210> 16459
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16459
caaggaag                                                                 8


<210> 16460
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16460
aaggaagaug gcauuucuag                                                   20


<210> 16461
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16461
aaggaagaug gcauuucua                                                    19


<210> 16462
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16462
aaggaagaug gcauuuct                                                     18


<210> 16463
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16463
aaggaagaug gcauuuc                                                      17


<210> 16464
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16464
aaggaagaug gcauut                                                       16


<210> 16465
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16465
aaggaagaug gcaut                                                        15


<210> 16466
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16466
aaggaagaug gcat                                                         14


<210> 16467
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16467
aaggaagaug gca                                                          13


<210> 16468
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 16468
aaggaagaug gc                                                           12


<210> 16469
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16469
aaggaagaug g                                                            11


<210> 16470
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16470
aaggaagaug                                                              10


<210> 16471
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16471
aaggaagat                                                                9


<210> 16472
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16472
aaggaaga                                                                 8


<210> 16473
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16473
aggaagaugg cauuucuag                                                    19


<210> 16474
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16474
aggaagaugg cauuucua                                                     18


<210> 16475
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16475
aggaagaugg cauuuct                                                      17


<210> 16476
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 16476
aggaagaugg cauuuc                                                       16


<210> 16477
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16477
aggaagaugg cauut                                                        15


<210> 16478
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16478
aggaagaugg caut                                                         14


<210> 16479
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16479
aggaagaugg cat                                                          13


<210> 16480
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16480
aggaagaugg ca                                                           12


<210> 16481
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16481
aggaagaugg                                                              10


<210> 16482
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16482
aggaagaug                                                                9


<210> 16483
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16483
aggaagat                                                                 8


<210> 16484
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16484
ggaagauggc auuucuag                                                     18


<210> 16485
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16485
ggaagauggc auuucua                                                      17


<210> 16486
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16486
ggaagauggc auuuct                                                       16


<210> 16487
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 16487
ggaagauggc auuuc                                                        15


<210> 16488
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16488
ggaagauggc auut                                                         14


<210> 16489
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16489
ggaagauggc aut                                                          13


<210> 16490
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16490
ggaagauggc at                                                           12


<210> 16491
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16491
ggaagauggc a                                                            11


<210> 16492
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 16492
ggaagauggc                                                              10


<210> 16493
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16493
ggaagaug                                                                 8


<210> 16494
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16494
gaagauggca uuucuag                                                      17


<210> 16495
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16495
gaagauggca uuucua                                                       16


<210> 16496
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 16496
gaagauggca uuuc                                                         14


<210> 16497
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16497
gaagauggca uut                                                          13


<210> 16498
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16498
gaagauggca ut                                                           12


<210> 16499
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16499
gaagauggca t                                                            11


<210> 16500
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16500
gaagauggca                                                              10


<210> 16501
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 16501
gaagauggc                                                                9


<210> 16502
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16502
gaagaugg                                                                 8


<210> 16503
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16503
aagauggcau uucuag                                                       16


<210> 16504
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16504
aagauggcau uucua                                                        15


<210> 16505
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16505
aagauggcau uuct                                                         14


<210> 16506
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 16506
aagauggcau uuc                                                          13


<210> 16507
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16507
aagauggcau ut                                                           12


<210> 16508
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16508
aagauggcau t                                                            11


<210> 16509
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16509
aagauggcat                                                              10


<210> 16510
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16510
aagauggca                                                                9


<210> 16511
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 16511
aagauggc                                                                 8


<210> 16512
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16512
agauggcauu ucuag                                                        15


<210> 16513
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16513
agauggcauu ucua                                                         14


<210> 16514
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16514
agauggcauu uct                                                          13


<210> 16515
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 16515
agauggcauu uc                                                           12


<210> 16516
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16516
agauggcauu t                                                            11


<210> 16517
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16517
agauggcaut                                                              10


<210> 16518
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 16518
agauggcat                                                                9


<210> 16519
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 16519
agauggca                                                                 8


<210> 16520
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 16520
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 16521
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 16521
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 16522
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 16522
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 16523
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<400> 16523
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 16524
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 16524
cuccaacauc aaggaagaug gcauut                                            26


<210> 16525
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 16525
cuccaacauc aaggaagaug gcaut                                             25


<210> 16526
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16526
cuccaacauc aaggaagaug gcat                                              24


<210> 16527
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16527
cuccaacauc aaggaagaug gca                                               23


<210> 16528
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 16528
cuccaacauc aaggaagaug gc                                                22


<210> 16529
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16529
cuccaacauc aaggaagaug g                                                 21


<210> 16530
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16530
cuccaacauc aaggaagaug                                                   20


<210> 16531
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16531
cuccaacauc aaggaagat                                                    19


<210> 16532
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16532
cuccaacauc aaggaaga                                                     18


<210> 16533
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16533
cuccaacauc aaggaag                                                      17


<210> 16534
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 16534
tccaacauca aggaagaugg cauuucuag                                         29


<210> 16535
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 16535
tccaacauca aggaagaugg cauuucua                                          28


<210> 16536
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 16536
tccaacauca aggaagaugg cauuuct                                           27


<210> 16537
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<400> 16537
tccaacauca aggaagaugg cauuuc                                            26


<210> 16538
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 16538
tccaacauca aggaagaugg cauut                                             25


<210> 16539
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16539
tccaacauca aggaagaugg caut                                              24


<210> 16540
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16540
tccaacauca aggaagaugg cat                                               23


<210> 16541
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16541
tccaacauca aggaagaugg ca                                                22


<210> 16542
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 16542
tccaacauca aggaagaugg c                                                 21


<210> 16543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16543
tccaacauca aggaagaugg                                                   20


<210> 16544
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16544
tccaacauca aggaagaug                                                    19


<210> 16545
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16545
tccaacauca aggaagat                                                     18


<210> 16546
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16546
tccaacauca aggaaga                                                      17


<210> 16547
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16547
tccaacauca aggaag                                                       16


<210> 16548
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 16548
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 16549
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 16549
ccaacaucaa ggaagauggc auuucua                                           27


<210> 16550
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 16550
ccaacaucaa ggaagauggc auuuct                                            26


<210> 16551
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<400> 16551
ccaacaucaa ggaagauggc auuuc                                             25


<210> 16552
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16552
ccaacaucaa ggaagauggc auut                                              24


<210> 16553
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16553
ccaacaucaa ggaagauggc aut                                               23


<210> 16554
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16554
ccaacaucaa ggaagauggc at                                                22


<210> 16555
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16555
ccaacaucaa ggaagauggc a                                                 21


<210> 16556
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16556
ccaacaucaa ggaagauggc                                                   20


<210> 16557
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16557
ccaacaucaa ggaagaugg                                                    19


<210> 16558
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16558
ccaacaucaa ggaagaug                                                     18


<210> 16559
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16559
ccaacaucaa ggaagat                                                      17


<210> 16560
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16560
ccaacaucaa ggaaga                                                       16


<210> 16561
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16561
ccaacaucaa ggaag                                                        15


<210> 16562
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 16562
caacaucaag gaagauggca uuucuag                                           27


<210> 16563
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 16563
caacaucaag gaagauggca uuucua                                            26


<210> 16564
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 16564
caacaucaag gaagauggca uuuct                                             25


<210> 16565
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<400> 16565
caacaucaag gaagauggca uuuc                                              24


<210> 16566
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16566
caacaucaag gaagauggca uut                                               23


<210> 16567
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16567
caacaucaag gaagauggca ut                                                22


<210> 16568
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16568
caacaucaag gaagauggca t                                                 21


<210> 16569
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16569
caacaucaag gaagauggca                                                   20


<210> 16570
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 16570
caacaucaag gaagauggc                                                    19


<210> 16571
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16571
caacaucaag gaagaugg                                                     18


<210> 16572
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16572
caacaucaag gaagaug                                                      17


<210> 16573
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16573
caacaucaag gaagat                                                       16


<210> 16574
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16574
caacaucaag gaaga                                                        15


<210> 16575
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16575
caacaucaag gaag                                                         14


<210> 16576
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 16576
aacaucaagg aagauggcau uucuag                                            26


<210> 16577
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 16577
aacaucaagg aagauggcau uucua                                             25


<210> 16578
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16578
aacaucaagg aagauggcau uuct                                              24


<210> 16579
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 16579
aacaucaagg aagauggcau uuc                                               23


<210> 16580
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16580
aacaucaagg aagauggcau ut                                                22


<210> 16581
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16581
aacaucaagg aagauggcau t                                                 21


<210> 16582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16582
aacaucaagg aagauggcat                                                   20


<210> 16583
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16583
aacaucaagg aagauggca                                                    19


<210> 16584
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16584
aacaucaagg aagauggc                                                     18


<210> 16585
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16585
aacaucaagg aagaugg                                                      17


<210> 16586
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16586
aacaucaagg aagaug                                                       16


<210> 16587
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16587
aacaucaagg aagat                                                        15


<210> 16588
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16588
aacaucaagg aaga                                                         14


<210> 16589
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16589
aacaucaagg aag                                                          13


<210> 16590
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 16590
acaucaagga agauggcauu ucuag                                             25


<210> 16591
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16591
acaucaagga agauggcauu ucua                                              24


<210> 16592
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16592
acaucaagga agauggcauu uct                                               23


<210> 16593
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 16593
acaucaagga agauggcauu uc                                                22


<210> 16594
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16594
acaucaagga agauggcauu t                                                 21


<210> 16595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16595
acaucaagga agauggcaut                                                   20


<210> 16596
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16596
acaucaagga agauggcat                                                    19


<210> 16597
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16597
acaucaagga agauggca                                                     18


<210> 16598
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16598
acaucaagga agauggc                                                      17


<210> 16599
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16599
acaucaagga agaugg                                                       16


<210> 16600
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16600
acaucaagga agaug                                                        15


<210> 16601
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16601
acaucaagga agat                                                         14


<210> 16602
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16602
acaucaagga aga                                                          13


<210> 16603
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16603
acaucaagga ag                                                           12


<210> 16604
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 16604
caucaaggaa gauggcauuu cuag                                              24


<210> 16605
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16605
caucaaggaa gauggcauuu cua                                               23


<210> 16606
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16606
caucaaggaa gauggcauuu ct                                                22


<210> 16607
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 16607
caucaaggaa gauggcauuu c                                                 21


<210> 16608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 16608
caucaaggaa gauggcauut                                                   20


<210> 16609
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16609
caucaaggaa gauggcaut                                                    19


<210> 16610
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16610
caucaaggaa gauggcat                                                     18


<210> 16611
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16611
caucaaggaa gauggca                                                      17


<210> 16612
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 16612
caucaaggaa gauggc                                                       16


<210> 16613
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 16613
caucaaggaa gaugg                                                        15


<210> 16614
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16614
caucaaggaa gaug                                                         14


<210> 16615
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16615
caucaaggaa gat                                                          13


<210> 16616
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16616
caucaaggaa ga                                                           12


<210> 16617
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16617
caucaaggaa g                                                            11


<210> 16618
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16618
aucaaggaag auggcauuuc uag                                               23


<210> 16619
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16619
aucaaggaag auggcauuuc ua                                                22


<210> 16620
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 16620
aucaaggaag auggcauuuc t                                                 21


<210> 16621
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16621
aucaaggaag auggcauuuc                                                   20


<210> 16622
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16622
aucaaggaag auggcauut                                                    19


<210> 16623
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16623
aucaaggaag auggcaut                                                     18


<210> 16624
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16624
aucaaggaag auggcat                                                      17


<210> 16625
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 16625
aucaaggaag auggca                                                       16


<210> 16626
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 16626
aucaaggaag auggc                                                        15


<210> 16627
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 16627
aucaaggaag augg                                                         14


<210> 16628
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 16628
aucaaggaag aug                                                          13


<210> 16629
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 16629
aucaaggaag at                                                           12


<210> 16630
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 16630
aucaaggaag a                                                            11


<210> 16631
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 16631
aucaaggaag                                                              10


<210> 16632
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 16632
ccagagcagg uaccuccaac auc                                               23


<210> 16633
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 16633
ccagagcagg uaccucca                                                     18


<210> 16634
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 16634
ccucugugau uuuauaacuu gat                                               23


<210> 16635
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 16635
tcacccacca ucaccct                                                      17


<210> 16636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 16636
tgauauccuc aaggucaccc                                                   20


<210> 16637
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 16637
cugcuugaug aucaucucgu ug                                                22


<210> 16638
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 16638
cugcuugaug aucaucuc                                                     18


<210> 16639
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 16639
guuuccuuag uaaccacag                                                    19


<210> 16640
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 16640
guuuccuuag uaaccac                                                      17


<210> 16641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16641
tcaaggaaga uggcauuuct                                                   20


<210> 16642
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16642
tcaaggaaga uggcauuucu ag                                                22


<210> 16643
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16643
gguaaguucu guccaagc                                                     18


<210> 16644
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16644
guaaguucug uccaagcc                                                     18


<210> 16645
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16645
agucgguaag uucugucc                                                     18


<210> 16646
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16646
cuguccaagc ccgguuga                                                     18


<210> 16647
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16647
taaguucugu ccaag                                                        15


<210> 16648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16648
tucuguccaa gcccgguuga                                                   20


<210> 16649
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16649
tucuguccaa gcccgguug                                                    19


<210> 16650
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16650
tucuguccaa gcccggut                                                     18


<210> 16651
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16651
tucuguccaa gcccggt                                                      17


<210> 16652
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16652
tucuguccaa gcccgg                                                       16


<210> 16653
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16653
tucuguccaa gcccg                                                        15


<210> 16654
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16654
tucuguccaa gccc                                                         14


<210> 16655
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16655
tucuguccaa gcc                                                          13


<210> 16656
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16656
tucuguccaa gc                                                           12


<210> 16657
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16657
tucuguccaa g                                                            11


<210> 16658
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16658
tucuguccaa                                                              10


<210> 16659
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16659
tucugucca                                                                9


<210> 16660
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16660
tucugucc                                                                 8


<210> 16661
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16661
tcuguccaag cccgguuga                                                    19


<210> 16662
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16662
tcuguccaag cccgguug                                                     18


<210> 16663
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16663
tcuguccaag cccggut                                                      17


<210> 16664
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16664
tcuguccaag cccggt                                                       16


<210> 16665
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16665
tcuguccaag cccgg                                                        15


<210> 16666
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16666
tcuguccaag cccg                                                         14


<210> 16667
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16667
tcuguccaag ccc                                                          13


<210> 16668
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16668
tcuguccaag cc                                                           12


<210> 16669
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16669
tcuguccaag c                                                            11


<210> 16670
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16670
tcuguccaag                                                              10


<210> 16671
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16671
tcuguccaa                                                                9


<210> 16672
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16672
tcugucca                                                                 8


<210> 16673
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16673
cuguccaagc ccgguug                                                      17


<210> 16674
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16674
cuguccaagc ccggut                                                       16


<210> 16675
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16675
cuguccaagc ccggt                                                        15


<210> 16676
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16676
cuguccaagc ccgg                                                         14


<210> 16677
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16677
cuguccaagc ccg                                                          13


<210> 16678
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16678
cuguccaagc cc                                                           12


<210> 16679
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16679
cuguccaagc c                                                            11


<210> 16680
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16680
cuguccaagc                                                              10


<210> 16681
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16681
cuguccaag                                                                9


<210> 16682
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16682
cuguccaa                                                                 8


<210> 16683
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16683
guucugucca agcccgguug                                                   20


<210> 16684
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16684
guucugucca agcccggut                                                    19


<210> 16685
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16685
guucugucca agcccggt                                                     18


<210> 16686
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16686
guucugucca agcccgg                                                      17


<210> 16687
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16687
guucugucca agcccg                                                       16


<210> 16688
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16688
guucugucca agccc                                                        15


<210> 16689
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16689
guucugucca agcc                                                         14


<210> 16690
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16690
guucugucca agc                                                          13


<210> 16691
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16691
guucugucca ag                                                           12


<210> 16692
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16692
guucugucca a                                                            11


<210> 16693
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16693
guucugucca                                                              10


<210> 16694
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16694
guucugucc                                                                9


<210> 16695
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16695
guucuguc                                                                 8


<210> 16696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16696
aguucugucc aagcccggut                                                   20


<210> 16697
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16697
aguucugucc aagcccggt                                                    19


<210> 16698
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16698
aguucugucc aagcccgg                                                     18


<210> 16699
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16699
aguucugucc aagcccg                                                      17


<210> 16700
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16700
aguucugucc aagccc                                                       16


<210> 16701
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16701
aguucugucc aagcc                                                        15


<210> 16702
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16702
aguucugucc aagc                                                         14


<210> 16703
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16703
aguucugucc aag                                                          13


<210> 16704
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16704
aguucugucc aa                                                           12


<210> 16705
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16705
aguucugucc a                                                            11


<210> 16706
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16706
aguucugucc                                                              10


<210> 16707
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16707
aguucuguc                                                                9


<210> 16708
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16708
aguucugt                                                                 8


<210> 16709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16709
aaguucuguc caagcccggt                                                   20


<210> 16710
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16710
aaguucuguc caagcccgg                                                    19


<210> 16711
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16711
aaguucuguc caagcccg                                                     18


<210> 16712
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16712
aaguucuguc caagccc                                                      17


<210> 16713
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16713
aaguucuguc caagcc                                                       16


<210> 16714
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16714
aaguucuguc caagc                                                        15


<210> 16715
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16715
aaguucuguc caag                                                         14


<210> 16716
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16716
aaguucuguc caa                                                          13


<210> 16717
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16717
aaguucuguc ca                                                           12


<210> 16718
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16718
aaguucuguc c                                                            11


<210> 16719
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16719
aaguucuguc                                                              10


<210> 16720
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16720
aaguucugt                                                                9


<210> 16721
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16721
aaguucug                                                                 8


<210> 16722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16722
taaguucugu ccaagcccgg                                                   20


<210> 16723
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16723
taaguucugu ccaagcccg                                                    19


<210> 16724
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16724
taaguucugu ccaagccc                                                     18


<210> 16725
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16725
taaguucugu ccaagcc                                                      17


<210> 16726
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16726
taaguucugu ccaagc                                                       16


<210> 16727
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16727
taaguucugu ccaa                                                         14


<210> 16728
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16728
taaguucugu cca                                                          13


<210> 16729
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16729
taaguucugu cc                                                           12


<210> 16730
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16730
taaguucugu c                                                            11


<210> 16731
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16731
taaguucugt                                                              10


<210> 16732
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16732
taaguucug                                                                9


<210> 16733
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16733
taaguuct                                                                 8


<210> 16734
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16734
guaaguucug uccaagcccg                                                   20


<210> 16735
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16735
guaaguucug uccaagccc                                                    19


<210> 16736
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16736
guaaguucug uccaagc                                                      17


<210> 16737
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16737
guaaguucug uccaag                                                       16


<210> 16738
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16738
guaaguucug uccaa                                                        15


<210> 16739
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16739
guaaguucug ucca                                                         14


<210> 16740
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16740
guaaguucug ucc                                                          13


<210> 16741
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16741
guaaguucug uc                                                           12


<210> 16742
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16742
guaaguucug t                                                            11


<210> 16743
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16743
guaaguucug                                                              10


<210> 16744
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16744
guaaguuct                                                                9


<210> 16745
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16745
guaaguuc                                                                 8


<210> 16746
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16746
gguaaguucu guccaagccc                                                   20


<210> 16747
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16747
gguaaguucu guccaagcc                                                    19


<210> 16748
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16748
gguaaguucu guccaag                                                      17


<210> 16749
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16749
gguaaguucu guccaa                                                       16


<210> 16750
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16750
gguaaguucu gucca                                                        15


<210> 16751
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16751
gguaaguucu gucc                                                         14


<210> 16752
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16752
gguaaguucu guc                                                          13


<210> 16753
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16753
gguaaguucu gt                                                           12


<210> 16754
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16754
gguaaguucu g                                                            11


<210> 16755
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16755
gguaaguuct                                                              10


<210> 16756
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16756
gguaaguuc                                                                9


<210> 16757
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16757
gguaagut                                                                 8


<210> 16758
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16758
cgguaaguuc uguccaagcc                                                   20


<210> 16759
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16759
cgguaaguuc uguccaagc                                                    19


<210> 16760
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16760
cgguaaguuc uguccaag                                                     18


<210> 16761
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16761
cgguaaguuc uguccaa                                                      17


<210> 16762
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16762
cgguaaguuc ugucca                                                       16


<210> 16763
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16763
cgguaaguuc ugucc                                                        15


<210> 16764
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16764
cgguaaguuc uguc                                                         14


<210> 16765
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16765
cgguaaguuc ugt                                                          13


<210> 16766
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16766
cgguaaguuc ug                                                           12


<210> 16767
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16767
cgguaaguuc t                                                            11


<210> 16768
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16768
cgguaaguuc                                                              10


<210> 16769
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16769
cgguaagut                                                                9


<210> 16770
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16770
cgguaagt                                                                 8


<210> 16771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16771
tcgguaaguu cuguccaagc                                                   20


<210> 16772
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16772
tcgguaaguu cuguccaag                                                    19


<210> 16773
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16773
tcgguaaguu cuguccaa                                                     18


<210> 16774
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16774
tcgguaaguu cugucca                                                      17


<210> 16775
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16775
tcgguaaguu cugucc                                                       16


<210> 16776
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16776
tcgguaaguu cuguc                                                        15


<210> 16777
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16777
tcgguaaguu cugt                                                         14


<210> 16778
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16778
tcgguaaguu cug                                                          13


<210> 16779
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16779
tcgguaaguu ct                                                           12


<210> 16780
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16780
tcgguaaguu c                                                            11


<210> 16781
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16781
tcgguaagut                                                              10


<210> 16782
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16782
tcgguaagt                                                                9


<210> 16783
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16783
gucgguaagu ucuguccaag                                                   20


<210> 16784
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16784
gucgguaagu ucuguccaa                                                    19


<210> 16785
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16785
gucgguaagu ucugucca                                                     18


<210> 16786
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16786
gucgguaagu ucugucc                                                      17


<210> 16787
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16787
gucgguaagu ucuguc                                                       16


<210> 16788
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16788
gucgguaagu ucugt                                                        15


<210> 16789
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16789
gucgguaagu ucug                                                         14


<210> 16790
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16790
gucgguaagu uct                                                          13


<210> 16791
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16791
gucgguaagu uc                                                           12


<210> 16792
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16792
gucgguaagu t                                                            11


<210> 16793
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16793
gucgguaagt                                                              10


<210> 16794
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16794
agucgguaag uucuguccaa                                                   20


<210> 16795
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16795
agucgguaag uucugucca                                                    19


<210> 16796
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16796
agucgguaag uucuguc                                                      17


<210> 16797
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16797
agucgguaag uucugt                                                       16


<210> 16798
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16798
agucgguaag uucug                                                        15


<210> 16799
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16799
agucgguaag uuct                                                         14


<210> 16800
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16800
agucgguaag uuc                                                          13


<210> 16801
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16801
agucgguaag ut                                                           12


<210> 16802
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16802
agucgguaag t                                                            11


<210> 16803
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16803
cagucgguaa guucugucca                                                   20


<210> 16804
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16804
cagucgguaa guucugucc                                                    19


<210> 16805
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16805
cagucgguaa guucuguc                                                     18


<210> 16806
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16806
cagucgguaa guucugt                                                      17


<210> 16807
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16807
cagucgguaa guucug                                                       16


<210> 16808
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16808
cagucgguaa guuct                                                        15


<210> 16809
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16809
cagucgguaa guuc                                                         14


<210> 16810
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16810
cagucgguaa gut                                                          13


<210> 16811
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16811
cagucgguaa gt                                                           12


<210> 16812
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16812
ccagucggua aguucugucc                                                   20


<210> 16813
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16813
ccagucggua aguucuguc                                                    19


<210> 16814
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16814
ccagucggua aguucugt                                                     18


<210> 16815
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16815
ccagucggua aguucug                                                      17


<210> 16816
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16816
ccagucggua aguuct                                                       16


<210> 16817
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16817
ccagucggua aguuc                                                        15


<210> 16818
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16818
ccagucggua agut                                                         14


<210> 16819
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16819
ccagucggua agt                                                          13


<210> 16820
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16820
gccagucggu aaguucuguc                                                   20


<210> 16821
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16821
gccagucggu aaguucugt                                                    19


<210> 16822
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16822
gccagucggu aaguucug                                                     18


<210> 16823
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16823
gccagucggu aaguuct                                                      17


<210> 16824
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16824
gccagucggu aaguuc                                                       16


<210> 16825
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16825
gccagucggu aagut                                                        15


<210> 16826
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16826
gccagucggu aagt                                                         14


<210> 16827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16827
tcaaggaaga uggcauuuct                                                   20


<210> 16828
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16828
tcaaggaaga uggcauuucu ag                                                22


<210> 16829
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16829
tcaaggaaga uggcat                                                       16


<210> 16830
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16830
gaagauggca uuuct                                                        15


<210> 16831
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16831
tcaaggaaga uggcauuucu a                                                 21


<210> 16832
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16832
tcaaggaaga uggcauuuc                                                    19


<210> 16833
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16833
tcaaggaaga uggcauut                                                     18


<210> 16834
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16834
tcaaggaaga uggcaut                                                      17


<210> 16835
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16835
tcaaggaaga uggca                                                        15


<210> 16836
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16836
tcaaggaaga uggc                                                         14


<210> 16837
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16837
tcaaggaaga ugg                                                          13


<210> 16838
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16838
tcaaggaaga ug                                                           12


<210> 16839
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16839
tcaaggaaga t                                                            11


<210> 16840
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16840
tcaaggaaga                                                              10


<210> 16841
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16841
tcaaggaag                                                                9


<210> 16842
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16842
caaggaagau ggcauuucua g                                                 21


<210> 16843
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16843
caaggaagau ggcauuucua                                                   20


<210> 16844
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16844
caaggaagau ggcauuuct                                                    19


<210> 16845
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16845
caaggaagau ggcauuuc                                                     18


<210> 16846
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16846
caaggaagau ggcauut                                                      17


<210> 16847
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16847
caaggaagau ggcaut                                                       16


<210> 16848
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16848
caaggaagau ggcat                                                        15


<210> 16849
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16849
caaggaagau ggca                                                         14


<210> 16850
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16850
caaggaagau ggc                                                          13


<210> 16851
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16851
caaggaagau gg                                                           12


<210> 16852
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16852
caaggaagau g                                                            11


<210> 16853
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16853
caaggaagat                                                              10


<210> 16854
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16854
caaggaaga                                                                9


<210> 16855
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16855
caaggaag                                                                 8


<210> 16856
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16856
aaggaagaug gcauuucuag                                                   20


<210> 16857
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16857
aaggaagaug gcauuucua                                                    19


<210> 16858
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16858
aaggaagaug gcauuuct                                                     18


<210> 16859
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16859
aaggaagaug gcauuuc                                                      17


<210> 16860
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16860
aaggaagaug gcauut                                                       16


<210> 16861
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16861
aaggaagaug gcaut                                                        15


<210> 16862
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16862
aaggaagaug gcat                                                         14


<210> 16863
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16863
aaggaagaug gca                                                          13


<210> 16864
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16864
aaggaagaug gc                                                           12


<210> 16865
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16865
aaggaagaug g                                                            11


<210> 16866
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16866
aaggaagaug                                                              10


<210> 16867
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16867
aaggaagat                                                                9


<210> 16868
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16868
aaggaaga                                                                 8


<210> 16869
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16869
aggaagaugg cauuucuag                                                    19


<210> 16870
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16870
aggaagaugg cauuucua                                                     18


<210> 16871
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16871
aggaagaugg cauuuct                                                      17


<210> 16872
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16872
aggaagaugg cauuuc                                                       16


<210> 16873
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16873
aggaagaugg cauut                                                        15


<210> 16874
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16874
aggaagaugg caut                                                         14


<210> 16875
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16875
aggaagaugg cat                                                          13


<210> 16876
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16876
aggaagaugg ca                                                           12


<210> 16877
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16877
aggaagaugg                                                              10


<210> 16878
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16878
aggaagaug                                                                9


<210> 16879
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16879
aggaagat                                                                 8


<210> 16880
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16880
ggaagauggc auuucuag                                                     18


<210> 16881
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16881
ggaagauggc auuucua                                                      17


<210> 16882
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16882
ggaagauggc auuuct                                                       16


<210> 16883
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16883
ggaagauggc auuuc                                                        15


<210> 16884
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16884
ggaagauggc auut                                                         14


<210> 16885
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16885
ggaagauggc aut                                                          13


<210> 16886
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16886
ggaagauggc at                                                           12


<210> 16887
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16887
ggaagauggc a                                                            11


<210> 16888
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16888
ggaagauggc                                                              10


<210> 16889
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16889
ggaagaug                                                                 8


<210> 16890
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16890
gaagauggca uuucuag                                                      17


<210> 16891
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16891
gaagauggca uuucua                                                       16


<210> 16892
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16892
gaagauggca uuuc                                                         14


<210> 16893
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16893
gaagauggca uut                                                          13


<210> 16894
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16894
gaagauggca ut                                                           12


<210> 16895
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16895
gaagauggca t                                                            11


<210> 16896
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16896
gaagauggca                                                              10


<210> 16897
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16897
gaagauggc                                                                9


<210> 16898
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16898
gaagaugg                                                                 8


<210> 16899
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16899
aagauggcau uucuag                                                       16


<210> 16900
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16900
aagauggcau uucua                                                        15


<210> 16901
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16901
aagauggcau uuct                                                         14


<210> 16902
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16902
aagauggcau uuc                                                          13


<210> 16903
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16903
aagauggcau ut                                                           12


<210> 16904
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16904
aagauggcau t                                                            11


<210> 16905
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16905
aagauggcat                                                              10


<210> 16906
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16906
aagauggca                                                                9


<210> 16907
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16907
aagauggc                                                                 8


<210> 16908
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16908
agauggcauu ucuag                                                        15


<210> 16909
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16909
agauggcauu ucua                                                         14


<210> 16910
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16910
agauggcauu uct                                                          13


<210> 16911
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16911
agauggcauu uc                                                           12


<210> 16912
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16912
agauggcauu t                                                            11


<210> 16913
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16913
agauggcaut                                                              10


<210> 16914
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16914
agauggcat                                                                9


<210> 16915
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16915
agauggca                                                                 8


<210> 16916
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16916
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 16917
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16917
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 16918
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16918
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 16919
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16919
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 16920
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16920
cuccaacauc aaggaagaug gcauut                                            26


<210> 16921
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16921
cuccaacauc aaggaagaug gcaut                                             25


<210> 16922
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16922
cuccaacauc aaggaagaug gcat                                              24


<210> 16923
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16923
cuccaacauc aaggaagaug gca                                               23


<210> 16924
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16924
cuccaacauc aaggaagaug gc                                                22


<210> 16925
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16925
cuccaacauc aaggaagaug g                                                 21


<210> 16926
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16926
cuccaacauc aaggaagaug                                                   20


<210> 16927
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16927
cuccaacauc aaggaagat                                                    19


<210> 16928
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16928
cuccaacauc aaggaaga                                                     18


<210> 16929
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16929
cuccaacauc aaggaag                                                      17


<210> 16930
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16930
tccaacauca aggaagaugg cauuucuag                                         29


<210> 16931
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16931
tccaacauca aggaagaugg cauuucua                                          28


<210> 16932
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16932
tccaacauca aggaagaugg cauuuct                                           27


<210> 16933
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16933
tccaacauca aggaagaugg cauuuc                                            26


<210> 16934
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16934
tccaacauca aggaagaugg cauut                                             25


<210> 16935
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16935
tccaacauca aggaagaugg caut                                              24


<210> 16936
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16936
tccaacauca aggaagaugg cat                                               23


<210> 16937
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16937
tccaacauca aggaagaugg ca                                                22


<210> 16938
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16938
tccaacauca aggaagaugg c                                                 21


<210> 16939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16939
tccaacauca aggaagaugg                                                   20


<210> 16940
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16940
tccaacauca aggaagaug                                                    19


<210> 16941
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16941
tccaacauca aggaagat                                                     18


<210> 16942
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16942
tccaacauca aggaaga                                                      17


<210> 16943
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16943
tccaacauca aggaag                                                       16


<210> 16944
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16944
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 16945
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16945
ccaacaucaa ggaagauggc auuucua                                           27


<210> 16946
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16946
ccaacaucaa ggaagauggc auuuct                                            26


<210> 16947
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16947
ccaacaucaa ggaagauggc auuuc                                             25


<210> 16948
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16948
ccaacaucaa ggaagauggc auut                                              24


<210> 16949
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16949
ccaacaucaa ggaagauggc aut                                               23


<210> 16950
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16950
ccaacaucaa ggaagauggc at                                                22


<210> 16951
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16951
ccaacaucaa ggaagauggc a                                                 21


<210> 16952
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16952
ccaacaucaa ggaagauggc                                                   20


<210> 16953
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16953
ccaacaucaa ggaagaugg                                                    19


<210> 16954
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16954
ccaacaucaa ggaagaug                                                     18


<210> 16955
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16955
ccaacaucaa ggaagat                                                      17


<210> 16956
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16956
ccaacaucaa ggaaga                                                       16


<210> 16957
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16957
ccaacaucaa ggaag                                                        15


<210> 16958
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16958
caacaucaag gaagauggca uuucuag                                           27


<210> 16959
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16959
caacaucaag gaagauggca uuucua                                            26


<210> 16960
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16960
caacaucaag gaagauggca uuuct                                             25


<210> 16961
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16961
caacaucaag gaagauggca uuuc                                              24


<210> 16962
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16962
caacaucaag gaagauggca uut                                               23


<210> 16963
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16963
caacaucaag gaagauggca ut                                                22


<210> 16964
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16964
caacaucaag gaagauggca t                                                 21


<210> 16965
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16965
caacaucaag gaagauggca                                                   20


<210> 16966
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16966
caacaucaag gaagauggc                                                    19


<210> 16967
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16967
caacaucaag gaagaugg                                                     18


<210> 16968
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16968
caacaucaag gaagaug                                                      17


<210> 16969
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16969
caacaucaag gaagat                                                       16


<210> 16970
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16970
caacaucaag gaaga                                                        15


<210> 16971
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16971
caacaucaag gaag                                                         14


<210> 16972
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16972
aacaucaagg aagauggcau uucuag                                            26


<210> 16973
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16973
aacaucaagg aagauggcau uucua                                             25


<210> 16974
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16974
aacaucaagg aagauggcau uuct                                              24


<210> 16975
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16975
aacaucaagg aagauggcau uuc                                               23


<210> 16976
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16976
aacaucaagg aagauggcau ut                                                22


<210> 16977
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16977
aacaucaagg aagauggcau t                                                 21


<210> 16978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16978
aacaucaagg aagauggcat                                                   20


<210> 16979
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16979
aacaucaagg aagauggca                                                    19


<210> 16980
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16980
aacaucaagg aagauggc                                                     18


<210> 16981
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16981
aacaucaagg aagaugg                                                      17


<210> 16982
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16982
aacaucaagg aagaug                                                       16


<210> 16983
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16983
aacaucaagg aagat                                                        15


<210> 16984
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16984
aacaucaagg aaga                                                         14


<210> 16985
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16985
aacaucaagg aag                                                          13


<210> 16986
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16986
acaucaagga agauggcauu ucuag                                             25


<210> 16987
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16987
acaucaagga agauggcauu ucua                                              24


<210> 16988
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16988
acaucaagga agauggcauu uct                                               23


<210> 16989
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16989
acaucaagga agauggcauu uc                                                22


<210> 16990
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16990
acaucaagga agauggcauu t                                                 21


<210> 16991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16991
acaucaagga agauggcaut                                                   20


<210> 16992
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16992
acaucaagga agauggcat                                                    19


<210> 16993
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16993
acaucaagga agauggca                                                     18


<210> 16994
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16994
acaucaagga agauggc                                                      17


<210> 16995
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16995
acaucaagga agaugg                                                       16


<210> 16996
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16996
acaucaagga agaug                                                        15


<210> 16997
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16997
acaucaagga agat                                                         14


<210> 16998
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16998
acaucaagga aga                                                          13


<210> 16999
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 16999
acaucaagga ag                                                           12


<210> 17000
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17000
caucaaggaa gauggcauuu cuag                                              24


<210> 17001
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17001
caucaaggaa gauggcauuu cua                                               23


<210> 17002
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17002
caucaaggaa gauggcauuu ct                                                22


<210> 17003
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17003
caucaaggaa gauggcauuu c                                                 21


<210> 17004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17004
caucaaggaa gauggcauut                                                   20


<210> 17005
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17005
caucaaggaa gauggcaut                                                    19


<210> 17006
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17006
caucaaggaa gauggcat                                                     18


<210> 17007
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17007
caucaaggaa gauggca                                                      17


<210> 17008
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17008
caucaaggaa gauggc                                                       16


<210> 17009
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17009
caucaaggaa gaugg                                                        15


<210> 17010
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17010
caucaaggaa gaug                                                         14


<210> 17011
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17011
caucaaggaa gat                                                          13


<210> 17012
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17012
caucaaggaa ga                                                           12


<210> 17013
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17013
caucaaggaa g                                                            11


<210> 17014
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17014
aucaaggaag auggcauuuc uag                                               23


<210> 17015
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17015
aucaaggaag auggcauuuc ua                                                22


<210> 17016
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17016
aucaaggaag auggcauuuc t                                                 21


<210> 17017
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17017
aucaaggaag auggcauuuc                                                   20


<210> 17018
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17018
aucaaggaag auggcauut                                                    19


<210> 17019
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17019
aucaaggaag auggcaut                                                     18


<210> 17020
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17020
aucaaggaag auggcat                                                      17


<210> 17021
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17021
aucaaggaag auggca                                                       16


<210> 17022
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17022
aucaaggaag auggc                                                        15


<210> 17023
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17023
aucaaggaag augg                                                         14


<210> 17024
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17024
aucaaggaag aug                                                          13


<210> 17025
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17025
aucaaggaag at                                                           12


<210> 17026
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17026
aucaaggaag a                                                            11


<210> 17027
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17027
aucaaggaag                                                              10


<210> 17028
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17028
ccagagcagg uaccuccaac auc                                               23


<210> 17029
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17029
ccagagcagg uaccucca                                                     18


<210> 17030
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17030
ccucugugau uuuauaacuu gat                                               23


<210> 17031
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17031
tcacccacca ucaccct                                                      17


<210> 17032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17032
tgauauccuc aaggucaccc                                                   20


<210> 17033
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17033
cugcuugaug aucaucucgu ug                                                22


<210> 17034
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17034
cugcuugaug aucaucuc                                                     18


<210> 17035
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17035
guuuccuuag uaaccacag                                                    19


<210> 17036
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17036
guuuccuuag uaaccac                                                      17


<210> 17037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17037
tcaaggaaga uggcauuuct                                                   20


<210> 17038
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17038
tcaaggaaga uggcauuucu ag                                                22


<210> 17039
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17039
gguaaguucu guccaagc                                                     18


<210> 17040
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17040
guaaguucug uccaagcc                                                     18


<210> 17041
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17041
agucgguaag uucugucc                                                     18


<210> 17042
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17042
cuguccaagc ccgguuga                                                     18


<210> 17043
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17043
taaguucugu ccaag                                                        15


<210> 17044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17044
tucuguccaa gcccgguuga                                                   20


<210> 17045
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17045
tucuguccaa gcccgguug                                                    19


<210> 17046
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17046
tucuguccaa gcccggut                                                     18


<210> 17047
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17047
tucuguccaa gcccggt                                                      17


<210> 17048
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17048
tucuguccaa gcccgg                                                       16


<210> 17049
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17049
tucuguccaa gcccg                                                        15


<210> 17050
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17050
tucuguccaa gccc                                                         14


<210> 17051
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17051
tucuguccaa gcc                                                          13


<210> 17052
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17052
tucuguccaa gc                                                           12


<210> 17053
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17053
tucuguccaa g                                                            11


<210> 17054
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17054
tucuguccaa                                                              10


<210> 17055
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17055
tucugucca                                                                9


<210> 17056
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17056
tucugucc                                                                 8


<210> 17057
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17057
tcuguccaag cccgguuga                                                    19


<210> 17058
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17058
tcuguccaag cccgguug                                                     18


<210> 17059
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17059
tcuguccaag cccggut                                                      17


<210> 17060
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17060
tcuguccaag cccggt                                                       16


<210> 17061
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17061
tcuguccaag cccgg                                                        15


<210> 17062
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17062
tcuguccaag cccg                                                         14


<210> 17063
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17063
tcuguccaag ccc                                                          13


<210> 17064
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17064
tcuguccaag cc                                                           12


<210> 17065
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17065
tcuguccaag c                                                            11


<210> 17066
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17066
tcuguccaag                                                              10


<210> 17067
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17067
tcuguccaa                                                                9


<210> 17068
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17068
tcugucca                                                                 8


<210> 17069
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17069
cuguccaagc ccgguug                                                      17


<210> 17070
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17070
cuguccaagc ccggut                                                       16


<210> 17071
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17071
cuguccaagc ccggt                                                        15


<210> 17072
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17072
cuguccaagc ccgg                                                         14


<210> 17073
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17073
cuguccaagc ccg                                                          13


<210> 17074
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17074
cuguccaagc cc                                                           12


<210> 17075
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17075
cuguccaagc c                                                            11


<210> 17076
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17076
cuguccaagc                                                              10


<210> 17077
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17077
cuguccaag                                                                9


<210> 17078
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17078
cuguccaa                                                                 8


<210> 17079
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17079
guucugucca agcccgguug                                                   20


<210> 17080
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17080
guucugucca agcccggut                                                    19


<210> 17081
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17081
guucugucca agcccggt                                                     18


<210> 17082
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17082
guucugucca agcccgg                                                      17


<210> 17083
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17083
guucugucca agcccg                                                       16


<210> 17084
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17084
guucugucca agccc                                                        15


<210> 17085
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17085
guucugucca agcc                                                         14


<210> 17086
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17086
guucugucca agc                                                          13


<210> 17087
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17087
guucugucca ag                                                           12


<210> 17088
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17088
guucugucca a                                                            11


<210> 17089
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17089
guucugucca                                                              10


<210> 17090
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17090
guucugucc                                                                9


<210> 17091
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17091
guucuguc                                                                 8


<210> 17092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17092
aguucugucc aagcccggut                                                   20


<210> 17093
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17093
aguucugucc aagcccggt                                                    19


<210> 17094
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17094
aguucugucc aagcccgg                                                     18


<210> 17095
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17095
aguucugucc aagcccg                                                      17


<210> 17096
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17096
aguucugucc aagccc                                                       16


<210> 17097
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17097
aguucugucc aagcc                                                        15


<210> 17098
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17098
aguucugucc aagc                                                         14


<210> 17099
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17099
aguucugucc aag                                                          13


<210> 17100
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17100
aguucugucc aa                                                           12


<210> 17101
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17101
aguucugucc a                                                            11


<210> 17102
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17102
aguucugucc                                                              10


<210> 17103
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17103
aguucuguc                                                                9


<210> 17104
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17104
aguucugt                                                                 8


<210> 17105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17105
aaguucuguc caagcccggt                                                   20


<210> 17106
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17106
aaguucuguc caagcccgg                                                    19


<210> 17107
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17107
aaguucuguc caagcccg                                                     18


<210> 17108
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17108
aaguucuguc caagccc                                                      17


<210> 17109
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17109
aaguucuguc caagcc                                                       16


<210> 17110
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17110
aaguucuguc caagc                                                        15


<210> 17111
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17111
aaguucuguc caag                                                         14


<210> 17112
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17112
aaguucuguc caa                                                          13


<210> 17113
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17113
aaguucuguc ca                                                           12


<210> 17114
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17114
aaguucuguc c                                                            11


<210> 17115
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17115
aaguucuguc                                                              10


<210> 17116
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17116
aaguucugt                                                                9


<210> 17117
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17117
aaguucug                                                                 8


<210> 17118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17118
taaguucugu ccaagcccgg                                                   20


<210> 17119
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17119
taaguucugu ccaagcccg                                                    19


<210> 17120
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17120
taaguucugu ccaagccc                                                     18


<210> 17121
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17121
taaguucugu ccaagcc                                                      17


<210> 17122
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17122
taaguucugu ccaagc                                                       16


<210> 17123
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17123
taaguucugu ccaa                                                         14


<210> 17124
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17124
taaguucugu cca                                                          13


<210> 17125
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17125
taaguucugu cc                                                           12


<210> 17126
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17126
taaguucugu c                                                            11


<210> 17127
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17127
taaguucugt                                                              10


<210> 17128
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17128
taaguucug                                                                9


<210> 17129
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17129
taaguuct                                                                 8


<210> 17130
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17130
guaaguucug uccaagcccg                                                   20


<210> 17131
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17131
guaaguucug uccaagccc                                                    19


<210> 17132
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17132
guaaguucug uccaagc                                                      17


<210> 17133
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17133
guaaguucug uccaag                                                       16


<210> 17134
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17134
guaaguucug uccaa                                                        15


<210> 17135
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17135
guaaguucug ucca                                                         14


<210> 17136
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17136
guaaguucug ucc                                                          13


<210> 17137
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17137
guaaguucug uc                                                           12


<210> 17138
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17138
guaaguucug t                                                            11


<210> 17139
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17139
guaaguucug                                                              10


<210> 17140
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17140
guaaguuct                                                                9


<210> 17141
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17141
guaaguuc                                                                 8


<210> 17142
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17142
gguaaguucu guccaagccc                                                   20


<210> 17143
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17143
gguaaguucu guccaagcc                                                    19


<210> 17144
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17144
gguaaguucu guccaag                                                      17


<210> 17145
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17145
gguaaguucu guccaa                                                       16


<210> 17146
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17146
gguaaguucu gucca                                                        15


<210> 17147
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17147
gguaaguucu gucc                                                         14


<210> 17148
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17148
gguaaguucu guc                                                          13


<210> 17149
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17149
gguaaguucu gt                                                           12


<210> 17150
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17150
gguaaguucu g                                                            11


<210> 17151
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17151
gguaaguuct                                                              10


<210> 17152
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17152
gguaaguuc                                                                9


<210> 17153
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17153
gguaagut                                                                 8


<210> 17154
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17154
cgguaaguuc uguccaagcc                                                   20


<210> 17155
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17155
cgguaaguuc uguccaagc                                                    19


<210> 17156
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17156
cgguaaguuc uguccaag                                                     18


<210> 17157
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17157
cgguaaguuc uguccaa                                                      17


<210> 17158
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17158
cgguaaguuc ugucca                                                       16


<210> 17159
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17159
cgguaaguuc ugucc                                                        15


<210> 17160
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17160
cgguaaguuc uguc                                                         14


<210> 17161
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17161
cgguaaguuc ugt                                                          13


<210> 17162
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17162
cgguaaguuc ug                                                           12


<210> 17163
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17163
cgguaaguuc t                                                            11


<210> 17164
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17164
cgguaaguuc                                                              10


<210> 17165
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17165
cgguaagut                                                                9


<210> 17166
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17166
cgguaagt                                                                 8


<210> 17167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17167
tcgguaaguu cuguccaagc                                                   20


<210> 17168
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17168
tcgguaaguu cuguccaag                                                    19


<210> 17169
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17169
tcgguaaguu cuguccaa                                                     18


<210> 17170
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17170
tcgguaaguu cugucca                                                      17


<210> 17171
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17171
tcgguaaguu cugucc                                                       16


<210> 17172
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17172
tcgguaaguu cuguc                                                        15


<210> 17173
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17173
tcgguaaguu cugt                                                         14


<210> 17174
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17174
tcgguaaguu cug                                                          13


<210> 17175
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17175
tcgguaaguu ct                                                           12


<210> 17176
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17176
tcgguaaguu c                                                            11


<210> 17177
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17177
tcgguaagut                                                              10


<210> 17178
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17178
tcgguaagt                                                                9


<210> 17179
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17179
gucgguaagu ucuguccaag                                                   20


<210> 17180
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17180
gucgguaagu ucuguccaa                                                    19


<210> 17181
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17181
gucgguaagu ucugucca                                                     18


<210> 17182
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17182
gucgguaagu ucugucc                                                      17


<210> 17183
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17183
gucgguaagu ucuguc                                                       16


<210> 17184
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17184
gucgguaagu ucugt                                                        15


<210> 17185
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17185
gucgguaagu ucug                                                         14


<210> 17186
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17186
gucgguaagu uct                                                          13


<210> 17187
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17187
gucgguaagu uc                                                           12


<210> 17188
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17188
gucgguaagu t                                                            11


<210> 17189
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17189
gucgguaagt                                                              10


<210> 17190
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17190
agucgguaag uucuguccaa                                                   20


<210> 17191
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17191
agucgguaag uucugucca                                                    19


<210> 17192
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17192
agucgguaag uucuguc                                                      17


<210> 17193
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17193
agucgguaag uucugt                                                       16


<210> 17194
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17194
agucgguaag uucug                                                        15


<210> 17195
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17195
agucgguaag uuct                                                         14


<210> 17196
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17196
agucgguaag uuc                                                          13


<210> 17197
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17197
agucgguaag ut                                                           12


<210> 17198
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17198
agucgguaag t                                                            11


<210> 17199
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17199
cagucgguaa guucugucca                                                   20


<210> 17200
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17200
cagucgguaa guucugucc                                                    19


<210> 17201
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17201
cagucgguaa guucuguc                                                     18


<210> 17202
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17202
cagucgguaa guucugt                                                      17


<210> 17203
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17203
cagucgguaa guucug                                                       16


<210> 17204
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17204
cagucgguaa guuct                                                        15


<210> 17205
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17205
cagucgguaa guuc                                                         14


<210> 17206
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17206
cagucgguaa gut                                                          13


<210> 17207
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17207
cagucgguaa gt                                                           12


<210> 17208
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17208
ccagucggua aguucugucc                                                   20


<210> 17209
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17209
ccagucggua aguucuguc                                                    19


<210> 17210
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17210
ccagucggua aguucugt                                                     18


<210> 17211
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17211
ccagucggua aguucug                                                      17


<210> 17212
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17212
ccagucggua aguuct                                                       16


<210> 17213
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17213
ccagucggua aguuc                                                        15


<210> 17214
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17214
ccagucggua agut                                                         14


<210> 17215
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17215
ccagucggua agt                                                          13


<210> 17216
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17216
gccagucggu aaguucuguc                                                   20


<210> 17217
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17217
gccagucggu aaguucugt                                                    19


<210> 17218
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17218
gccagucggu aaguucug                                                     18


<210> 17219
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17219
gccagucggu aaguuct                                                      17


<210> 17220
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17220
gccagucggu aaguuc                                                       16


<210> 17221
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17221
gccagucggu aagut                                                        15


<210> 17222
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17222
gccagucggu aagt                                                         14


<210> 17223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17223
tcaaggaaga uggcauuuct                                                   20


<210> 17224
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17224
tcaaggaaga uggcauuucu ag                                                22


<210> 17225
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17225
tcaaggaaga uggcat                                                       16


<210> 17226
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17226
gaagauggca uuuct                                                        15


<210> 17227
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17227
tcaaggaaga uggcauuucu a                                                 21


<210> 17228
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17228
tcaaggaaga uggcauuuc                                                    19


<210> 17229
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17229
tcaaggaaga uggcauut                                                     18


<210> 17230
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17230
tcaaggaaga uggcaut                                                      17


<210> 17231
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17231
tcaaggaaga uggca                                                        15


<210> 17232
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17232
tcaaggaaga uggc                                                         14


<210> 17233
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17233
tcaaggaaga ugg                                                          13


<210> 17234
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17234
tcaaggaaga ug                                                           12


<210> 17235
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17235
tcaaggaaga t                                                            11


<210> 17236
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17236
tcaaggaaga                                                              10


<210> 17237
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17237
tcaaggaag                                                                9


<210> 17238
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17238
caaggaagau ggcauuucua g                                                 21


<210> 17239
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17239
caaggaagau ggcauuucua                                                   20


<210> 17240
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17240
caaggaagau ggcauuuct                                                    19


<210> 17241
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17241
caaggaagau ggcauuuc                                                     18


<210> 17242
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17242
caaggaagau ggcauut                                                      17


<210> 17243
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17243
caaggaagau ggcaut                                                       16


<210> 17244
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17244
caaggaagau ggcat                                                        15


<210> 17245
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17245
caaggaagau ggca                                                         14


<210> 17246
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17246
caaggaagau ggc                                                          13


<210> 17247
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17247
caaggaagau gg                                                           12


<210> 17248
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17248
caaggaagau g                                                            11


<210> 17249
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17249
caaggaagat                                                              10


<210> 17250
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17250
caaggaaga                                                                9


<210> 17251
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17251
caaggaag                                                                 8


<210> 17252
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17252
aaggaagaug gcauuucuag                                                   20


<210> 17253
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17253
aaggaagaug gcauuucua                                                    19


<210> 17254
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17254
aaggaagaug gcauuuct                                                     18


<210> 17255
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17255
aaggaagaug gcauuuc                                                      17


<210> 17256
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17256
aaggaagaug gcauut                                                       16


<210> 17257
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17257
aaggaagaug gcaut                                                        15


<210> 17258
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17258
aaggaagaug gcat                                                         14


<210> 17259
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17259
aaggaagaug gca                                                          13


<210> 17260
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17260
aaggaagaug gc                                                           12


<210> 17261
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17261
aaggaagaug g                                                            11


<210> 17262
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17262
aaggaagaug                                                              10


<210> 17263
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17263
aaggaagat                                                                9


<210> 17264
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17264
aaggaaga                                                                 8


<210> 17265
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17265
aggaagaugg cauuucuag                                                    19


<210> 17266
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17266
aggaagaugg cauuucua                                                     18


<210> 17267
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17267
aggaagaugg cauuuct                                                      17


<210> 17268
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17268
aggaagaugg cauuuc                                                       16


<210> 17269
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17269
aggaagaugg cauut                                                        15


<210> 17270
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17270
aggaagaugg caut                                                         14


<210> 17271
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17271
aggaagaugg cat                                                          13


<210> 17272
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17272
aggaagaugg ca                                                           12


<210> 17273
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17273
aggaagaugg                                                              10


<210> 17274
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17274
aggaagaug                                                                9


<210> 17275
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17275
aggaagat                                                                 8


<210> 17276
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17276
ggaagauggc auuucuag                                                     18


<210> 17277
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17277
ggaagauggc auuucua                                                      17


<210> 17278
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17278
ggaagauggc auuuct                                                       16


<210> 17279
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17279
ggaagauggc auuuc                                                        15


<210> 17280
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17280
ggaagauggc auut                                                         14


<210> 17281
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17281
ggaagauggc aut                                                          13


<210> 17282
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17282
ggaagauggc at                                                           12


<210> 17283
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17283
ggaagauggc a                                                            11


<210> 17284
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17284
ggaagauggc                                                              10


<210> 17285
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17285
ggaagaug                                                                 8


<210> 17286
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17286
gaagauggca uuucuag                                                      17


<210> 17287
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17287
gaagauggca uuucua                                                       16


<210> 17288
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17288
gaagauggca uuuc                                                         14


<210> 17289
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17289
gaagauggca uut                                                          13


<210> 17290
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17290
gaagauggca ut                                                           12


<210> 17291
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17291
gaagauggca t                                                            11


<210> 17292
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17292
gaagauggca                                                              10


<210> 17293
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17293
gaagauggc                                                                9


<210> 17294
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17294
gaagaugg                                                                 8


<210> 17295
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17295
aagauggcau uucuag                                                       16


<210> 17296
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17296
aagauggcau uucua                                                        15


<210> 17297
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17297
aagauggcau uuct                                                         14


<210> 17298
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17298
aagauggcau uuc                                                          13


<210> 17299
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17299
aagauggcau ut                                                           12


<210> 17300
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17300
aagauggcau t                                                            11


<210> 17301
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17301
aagauggcat                                                              10


<210> 17302
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17302
aagauggca                                                                9


<210> 17303
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17303
aagauggc                                                                 8


<210> 17304
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17304
agauggcauu ucuag                                                        15


<210> 17305
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17305
agauggcauu ucua                                                         14


<210> 17306
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17306
agauggcauu uct                                                          13


<210> 17307
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17307
agauggcauu uc                                                           12


<210> 17308
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17308
agauggcauu t                                                            11


<210> 17309
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17309
agauggcaut                                                              10


<210> 17310
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17310
agauggcat                                                                9


<210> 17311
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17311
agauggca                                                                 8


<210> 17312
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17312
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 17313
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17313
cuccaacauc aaggaagaug gcauuucua                                         29


<210> 17314
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17314
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 17315
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17315
cuccaacauc aaggaagaug gcauuuc                                           27


<210> 17316
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17316
cuccaacauc aaggaagaug gcauut                                            26


<210> 17317
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17317
cuccaacauc aaggaagaug gcaut                                             25


<210> 17318
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17318
cuccaacauc aaggaagaug gcat                                              24


<210> 17319
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17319
cuccaacauc aaggaagaug gca                                               23


<210> 17320
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17320
cuccaacauc aaggaagaug gc                                                22


<210> 17321
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17321
cuccaacauc aaggaagaug g                                                 21


<210> 17322
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17322
cuccaacauc aaggaagaug                                                   20


<210> 17323
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17323
cuccaacauc aaggaagat                                                    19


<210> 17324
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17324
cuccaacauc aaggaaga                                                     18


<210> 17325
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17325
cuccaacauc aaggaag                                                      17


<210> 17326
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17326
tccaacauca aggaagaugg cauuucuag                                         29


<210> 17327
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17327
tccaacauca aggaagaugg cauuucua                                          28


<210> 17328
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17328
tccaacauca aggaagaugg cauuuct                                           27


<210> 17329
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17329
tccaacauca aggaagaugg cauuuc                                            26


<210> 17330
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17330
tccaacauca aggaagaugg cauut                                             25


<210> 17331
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17331
tccaacauca aggaagaugg caut                                              24


<210> 17332
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17332
tccaacauca aggaagaugg cat                                               23


<210> 17333
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17333
tccaacauca aggaagaugg ca                                                22


<210> 17334
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17334
tccaacauca aggaagaugg c                                                 21


<210> 17335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17335
tccaacauca aggaagaugg                                                   20


<210> 17336
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17336
tccaacauca aggaagaug                                                    19


<210> 17337
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17337
tccaacauca aggaagat                                                     18


<210> 17338
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17338
tccaacauca aggaaga                                                      17


<210> 17339
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17339
tccaacauca aggaag                                                       16


<210> 17340
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17340
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 17341
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17341
ccaacaucaa ggaagauggc auuucua                                           27


<210> 17342
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17342
ccaacaucaa ggaagauggc auuuct                                            26


<210> 17343
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17343
ccaacaucaa ggaagauggc auuuc                                             25


<210> 17344
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17344
ccaacaucaa ggaagauggc auut                                              24


<210> 17345
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17345
ccaacaucaa ggaagauggc aut                                               23


<210> 17346
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17346
ccaacaucaa ggaagauggc at                                                22


<210> 17347
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17347
ccaacaucaa ggaagauggc a                                                 21


<210> 17348
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17348
ccaacaucaa ggaagauggc                                                   20


<210> 17349
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17349
ccaacaucaa ggaagaugg                                                    19


<210> 17350
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17350
ccaacaucaa ggaagaug                                                     18


<210> 17351
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17351
ccaacaucaa ggaagat                                                      17


<210> 17352
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17352
ccaacaucaa ggaaga                                                       16


<210> 17353
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17353
ccaacaucaa ggaag                                                        15


<210> 17354
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17354
caacaucaag gaagauggca uuucuag                                           27


<210> 17355
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17355
caacaucaag gaagauggca uuucua                                            26


<210> 17356
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17356
caacaucaag gaagauggca uuuct                                             25


<210> 17357
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17357
caacaucaag gaagauggca uuuc                                              24


<210> 17358
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17358
caacaucaag gaagauggca uut                                               23


<210> 17359
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17359
caacaucaag gaagauggca ut                                                22


<210> 17360
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17360
caacaucaag gaagauggca t                                                 21


<210> 17361
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17361
caacaucaag gaagauggca                                                   20


<210> 17362
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17362
caacaucaag gaagauggc                                                    19


<210> 17363
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17363
caacaucaag gaagaugg                                                     18


<210> 17364
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17364
caacaucaag gaagaug                                                      17


<210> 17365
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17365
caacaucaag gaagat                                                       16


<210> 17366
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17366
caacaucaag gaaga                                                        15


<210> 17367
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17367
caacaucaag gaag                                                         14


<210> 17368
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17368
aacaucaagg aagauggcau uucuag                                            26


<210> 17369
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17369
aacaucaagg aagauggcau uucua                                             25


<210> 17370
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17370
aacaucaagg aagauggcau uuct                                              24


<210> 17371
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17371
aacaucaagg aagauggcau uuc                                               23


<210> 17372
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17372
aacaucaagg aagauggcau ut                                                22


<210> 17373
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17373
aacaucaagg aagauggcau t                                                 21


<210> 17374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17374
aacaucaagg aagauggcat                                                   20


<210> 17375
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17375
aacaucaagg aagauggca                                                    19


<210> 17376
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17376
aacaucaagg aagauggc                                                     18


<210> 17377
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17377
aacaucaagg aagaugg                                                      17


<210> 17378
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17378
aacaucaagg aagaug                                                       16


<210> 17379
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17379
aacaucaagg aagat                                                        15


<210> 17380
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17380
aacaucaagg aaga                                                         14


<210> 17381
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17381
aacaucaagg aag                                                          13


<210> 17382
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17382
acaucaagga agauggcauu ucuag                                             25


<210> 17383
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17383
acaucaagga agauggcauu ucua                                              24


<210> 17384
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17384
acaucaagga agauggcauu uct                                               23


<210> 17385
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17385
acaucaagga agauggcauu uc                                                22


<210> 17386
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17386
acaucaagga agauggcauu t                                                 21


<210> 17387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17387
acaucaagga agauggcaut                                                   20


<210> 17388
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17388
acaucaagga agauggcat                                                    19


<210> 17389
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17389
acaucaagga agauggca                                                     18


<210> 17390
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17390
acaucaagga agauggc                                                      17


<210> 17391
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17391
acaucaagga agaugg                                                       16


<210> 17392
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17392
acaucaagga agaug                                                        15


<210> 17393
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17393
acaucaagga agat                                                         14


<210> 17394
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17394
acaucaagga aga                                                          13


<210> 17395
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17395
acaucaagga ag                                                           12


<210> 17396
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17396
caucaaggaa gauggcauuu cuag                                              24


<210> 17397
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17397
caucaaggaa gauggcauuu cua                                               23


<210> 17398
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17398
caucaaggaa gauggcauuu ct                                                22


<210> 17399
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17399
caucaaggaa gauggcauuu c                                                 21


<210> 17400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17400
caucaaggaa gauggcauut                                                   20


<210> 17401
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17401
caucaaggaa gauggcaut                                                    19


<210> 17402
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17402
caucaaggaa gauggcat                                                     18


<210> 17403
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17403
caucaaggaa gauggca                                                      17


<210> 17404
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17404
caucaaggaa gauggc                                                       16


<210> 17405
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17405
caucaaggaa gaugg                                                        15


<210> 17406
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17406
caucaaggaa gaug                                                         14


<210> 17407
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17407
caucaaggaa gat                                                          13


<210> 17408
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17408
caucaaggaa ga                                                           12


<210> 17409
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17409
caucaaggaa g                                                            11


<210> 17410
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17410
aucaaggaag auggcauuuc uag                                               23


<210> 17411
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17411
aucaaggaag auggcauuuc ua                                                22


<210> 17412
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17412
aucaaggaag auggcauuuc t                                                 21


<210> 17413
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17413
aucaaggaag auggcauuuc                                                   20


<210> 17414
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17414
aucaaggaag auggcauut                                                    19


<210> 17415
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17415
aucaaggaag auggcaut                                                     18


<210> 17416
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17416
aucaaggaag auggcat                                                      17


<210> 17417
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17417
aucaaggaag auggca                                                       16


<210> 17418
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17418
aucaaggaag auggc                                                        15


<210> 17419
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17419
aucaaggaag augg                                                         14


<210> 17420
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17420
aucaaggaag aug                                                          13


<210> 17421
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17421
aucaaggaag at                                                           12


<210> 17422
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17422
aucaaggaag a                                                            11


<210> 17423
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17423
aucaaggaag                                                              10


<210> 17424
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17424
ccagagcagg uaccuccaac auc                                               23


<210> 17425
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17425
ccagagcagg uaccucca                                                     18


<210> 17426
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17426
ccucugugau uuuauaacuu gat                                               23


<210> 17427
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17427
tcacccacca ucaccct                                                      17


<210> 17428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17428
tgauauccuc aaggucaccc                                                   20


<210> 17429
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17429
cugcuugaug aucaucucgu ug                                                22


<210> 17430
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17430
cugcuugaug aucaucuc                                                     18


<210> 17431
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17431
guuuccuuag uaaccacag                                                    19


<210> 17432
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 17432
guuuccuuag uaaccac                                                      17


<210> 17433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17433
tcaaggaaga uggcauuucu                                                   20


<210> 17434
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17434
tcaaggaaga uggcauuucu ag                                                22


<210> 17435
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17435
gguaaguucu guccaagc                                                     18


<210> 17436
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17436
gtaaguucug uccaagcc                                                     18


<210> 17437
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17437
agucgguaag uucugucc                                                     18


<210> 17438
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17438
ctguccaagc ccgguuga                                                     18


<210> 17439
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17439
taaguucugu ccaag                                                        15


<210> 17440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17440
ttcuguccaa gcccgguuga                                                   20


<210> 17441
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17441
ttcuguccaa gcccgguug                                                    19


<210> 17442
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17442
ttcuguccaa gcccgguu                                                     18


<210> 17443
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17443
ttcuguccaa gcccggu                                                      17


<210> 17444
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17444
ttcuguccaa gcccgg                                                       16


<210> 17445
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17445
ttcuguccaa gcccg                                                        15


<210> 17446
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17446
ttcuguccaa gccc                                                         14


<210> 17447
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17447
ttcuguccaa gcc                                                          13


<210> 17448
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17448
ttcuguccaa gc                                                           12


<210> 17449
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17449
ttcuguccaa g                                                            11


<210> 17450
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17450
ttcuguccaa                                                              10


<210> 17451
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17451
ttcugucca                                                                9


<210> 17452
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17452
ttcugucc                                                                 8


<210> 17453
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17453
tcuguccaag cccgguuga                                                    19


<210> 17454
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17454
tcuguccaag cccgguug                                                     18


<210> 17455
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17455
tcuguccaag cccgguu                                                      17


<210> 17456
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17456
tcuguccaag cccggu                                                       16


<210> 17457
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17457
tcuguccaag cccgg                                                        15


<210> 17458
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17458
tcuguccaag cccg                                                         14


<210> 17459
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17459
tcuguccaag ccc                                                          13


<210> 17460
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17460
tcuguccaag cc                                                           12


<210> 17461
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17461
tcuguccaag c                                                            11


<210> 17462
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17462
tcuguccaag                                                              10


<210> 17463
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17463
tcuguccaa                                                                9


<210> 17464
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17464
tcugucca                                                                 8


<210> 17465
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17465
ctguccaagc ccgguug                                                      17


<210> 17466
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17466
ctguccaagc ccgguu                                                       16


<210> 17467
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17467
ctguccaagc ccggu                                                        15


<210> 17468
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17468
ctguccaagc ccgg                                                         14


<210> 17469
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17469
ctguccaagc ccg                                                          13


<210> 17470
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17470
ctguccaagc cc                                                           12


<210> 17471
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17471
ctguccaagc c                                                            11


<210> 17472
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17472
ctguccaagc                                                              10


<210> 17473
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17473
ctguccaag                                                                9


<210> 17474
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17474
ctguccaa                                                                 8


<210> 17475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17475
gtucugucca agcccgguug                                                   20


<210> 17476
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17476
gtucugucca agcccgguu                                                    19


<210> 17477
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17477
gtucugucca agcccggu                                                     18


<210> 17478
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17478
gtucugucca agcccgg                                                      17


<210> 17479
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17479
gtucugucca agcccg                                                       16


<210> 17480
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17480
gtucugucca agccc                                                        15


<210> 17481
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17481
gtucugucca agcc                                                         14


<210> 17482
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17482
gtucugucca agc                                                          13


<210> 17483
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17483
gtucugucca ag                                                           12


<210> 17484
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17484
gtucugucca a                                                            11


<210> 17485
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17485
gtucugucca                                                              10


<210> 17486
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17486
gtucugucc                                                                9


<210> 17487
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17487
gtucuguc                                                                 8


<210> 17488
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17488
aguucugucc aagcccgguu                                                   20


<210> 17489
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17489
aguucugucc aagcccggu                                                    19


<210> 17490
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17490
aguucugucc aagcccgg                                                     18


<210> 17491
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17491
aguucugucc aagcccg                                                      17


<210> 17492
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17492
aguucugucc aagccc                                                       16


<210> 17493
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17493
aguucugucc aagcc                                                        15


<210> 17494
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17494
aguucugucc aagc                                                         14


<210> 17495
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17495
aguucugucc aag                                                          13


<210> 17496
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17496
aguucugucc aa                                                           12


<210> 17497
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17497
aguucugucc a                                                            11


<210> 17498
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17498
aguucugucc                                                              10


<210> 17499
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17499
aguucuguc                                                                9


<210> 17500
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 17500
aguucugu                                                                 8


<210> 17501
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17501
aaguucuguc caagcccggu                                                   20


<210> 17502
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17502
aaguucuguc caagcccgg                                                    19


<210> 17503
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17503
aaguucuguc caagcccg                                                     18


<210> 17504
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17504
aaguucuguc caagccc                                                      17


<210> 17505
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17505
aaguucuguc caagcc                                                       16


<210> 17506
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17506
aaguucuguc caagc                                                        15


<210> 17507
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17507
aaguucuguc caag                                                         14


<210> 17508
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17508
aaguucuguc caa                                                          13


<210> 17509
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17509
aaguucuguc ca                                                           12


<210> 17510
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17510
aaguucuguc c                                                            11


<210> 17511
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17511
aaguucuguc                                                              10


<210> 17512
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17512
aaguucugu                                                                9


<210> 17513
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17513
aaguucug                                                                 8


<210> 17514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17514
taaguucugu ccaagcccgg                                                   20


<210> 17515
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17515
taaguucugu ccaagcccg                                                    19


<210> 17516
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17516
taaguucugu ccaagccc                                                     18


<210> 17517
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17517
taaguucugu ccaagcc                                                      17


<210> 17518
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17518
taaguucugu ccaagc                                                       16


<210> 17519
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17519
taaguucugu ccaa                                                         14


<210> 17520
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17520
taaguucugu cca                                                          13


<210> 17521
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17521
taaguucugu cc                                                           12


<210> 17522
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17522
taaguucugu c                                                            11


<210> 17523
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17523
taaguucugu                                                              10


<210> 17524
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17524
taaguucug                                                                9


<210> 17525
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17525
taaguucu                                                                 8


<210> 17526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17526
gtaaguucug uccaagcccg                                                   20


<210> 17527
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17527
gtaaguucug uccaagccc                                                    19


<210> 17528
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17528
gtaaguucug uccaagc                                                      17


<210> 17529
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17529
gtaaguucug uccaag                                                       16


<210> 17530
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17530
gtaaguucug uccaa                                                        15


<210> 17531
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17531
gtaaguucug ucca                                                         14


<210> 17532
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17532
gtaaguucug ucc                                                          13


<210> 17533
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17533
gtaaguucug uc                                                           12


<210> 17534
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17534
gtaaguucug u                                                            11


<210> 17535
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17535
gtaaguucug                                                              10


<210> 17536
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17536
gtaaguucu                                                                9


<210> 17537
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17537
gtaaguuc                                                                 8


<210> 17538
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17538
gguaaguucu guccaagccc                                                   20


<210> 17539
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17539
gguaaguucu guccaagcc                                                    19


<210> 17540
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17540
gguaaguucu guccaag                                                      17


<210> 17541
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17541
gguaaguucu guccaa                                                       16


<210> 17542
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17542
gguaaguucu gucca                                                        15


<210> 17543
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17543
gguaaguucu gucc                                                         14


<210> 17544
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17544
gguaaguucu guc                                                          13


<210> 17545
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17545
gguaaguucu gu                                                           12


<210> 17546
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17546
gguaaguucu g                                                            11


<210> 17547
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17547
gguaaguucu                                                              10


<210> 17548
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17548
gguaaguuc                                                                9


<210> 17549
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17549
gguaaguu                                                                 8


<210> 17550
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17550
cgguaaguuc uguccaagcc                                                   20


<210> 17551
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17551
cgguaaguuc uguccaagc                                                    19


<210> 17552
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17552
cgguaaguuc uguccaag                                                     18


<210> 17553
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17553
cgguaaguuc uguccaa                                                      17


<210> 17554
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17554
cgguaaguuc ugucca                                                       16


<210> 17555
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17555
cgguaaguuc ugucc                                                        15


<210> 17556
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17556
cgguaaguuc uguc                                                         14


<210> 17557
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17557
cgguaaguuc ugu                                                          13


<210> 17558
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17558
cgguaaguuc ug                                                           12


<210> 17559
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17559
cgguaaguuc u                                                            11


<210> 17560
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17560
cgguaaguuc                                                              10


<210> 17561
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17561
cgguaaguu                                                                9


<210> 17562
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17562
cgguaagu                                                                 8


<210> 17563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17563
tcgguaaguu cuguccaagc                                                   20


<210> 17564
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17564
tcgguaaguu cuguccaag                                                    19


<210> 17565
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17565
tcgguaaguu cuguccaa                                                     18


<210> 17566
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17566
tcgguaaguu cugucca                                                      17


<210> 17567
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17567
tcgguaaguu cugucc                                                       16


<210> 17568
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17568
tcgguaaguu cuguc                                                        15


<210> 17569
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17569
tcgguaaguu cugu                                                         14


<210> 17570
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17570
tcgguaaguu cug                                                          13


<210> 17571
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17571
tcgguaaguu cu                                                           12


<210> 17572
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17572
tcgguaaguu c                                                            11


<210> 17573
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 17573
tcgguaaguu                                                              10


<210> 17574
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 17574
tcgguaagu                                                                9


<210> 17575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17575
gtcgguaagu ucuguccaag                                                   20


<210> 17576
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17576
gtcgguaagu ucuguccaa                                                    19


<210> 17577
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17577
gtcgguaagu ucugucca                                                     18


<210> 17578
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17578
gtcgguaagu ucugucc                                                      17


<210> 17579
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17579
gtcgguaagu ucuguc                                                       16


<210> 17580
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17580
gtcgguaagu ucugu                                                        15


<210> 17581
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17581
gtcgguaagu ucug                                                         14


<210> 17582
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17582
gtcgguaagu ucu                                                          13


<210> 17583
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17583
gtcgguaagu uc                                                           12


<210> 17584
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 17584
gtcgguaagu u                                                            11


<210> 17585
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 17585
gtcgguaagu                                                              10


<210> 17586
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17586
agucgguaag uucuguccaa                                                   20


<210> 17587
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17587
agucgguaag uucugucca                                                    19


<210> 17588
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17588
agucgguaag uucuguc                                                      17


<210> 17589
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17589
agucgguaag uucugu                                                       16


<210> 17590
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17590
agucgguaag uucug                                                        15


<210> 17591
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17591
agucgguaag uucu                                                         14


<210> 17592
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17592
agucgguaag uuc                                                          13


<210> 17593
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 17593
agucgguaag uu                                                           12


<210> 17594
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 17594
agucgguaag u                                                            11


<210> 17595
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17595
cagucgguaa guucugucca                                                   20


<210> 17596
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17596
cagucgguaa guucugucc                                                    19


<210> 17597
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17597
cagucgguaa guucuguc                                                     18


<210> 17598
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17598
cagucgguaa guucugu                                                      17


<210> 17599
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17599
cagucgguaa guucug                                                       16


<210> 17600
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17600
cagucgguaa guucu                                                        15


<210> 17601
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17601
cagucgguaa guuc                                                         14


<210> 17602
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 17602
cagucgguaa guu                                                          13


<210> 17603
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 17603
cagucgguaa gu                                                           12


<210> 17604
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17604
ccagucggua aguucugucc                                                   20


<210> 17605
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17605
ccagucggua aguucuguc                                                    19


<210> 17606
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17606
ccagucggua aguucugu                                                     18


<210> 17607
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17607
ccagucggua aguucug                                                      17


<210> 17608
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17608
ccagucggua aguucu                                                       16


<210> 17609
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17609
ccagucggua aguuc                                                        15


<210> 17610
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17610
ccagucggua aguu                                                         14


<210> 17611
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17611
ccagucggua agu                                                          13


<210> 17612
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17612
gccagucggu aaguucuguc                                                   20


<210> 17613
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17613
gccagucggu aaguucugu                                                    19


<210> 17614
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17614
gccagucggu aaguucug                                                     18


<210> 17615
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17615
gccagucggu aaguucu                                                      17


<210> 17616
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17616
gccagucggu aaguuc                                                       16


<210> 17617
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17617
gccagucggu aaguu                                                        15


<210> 17618
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17618
gccagucggu aagu                                                         14


<210> 17619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17619
tcaaggaaga uggcauuucu                                                   20


<210> 17620
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17620
tcaaggaaga uggcauuucu ag                                                22


<210> 17621
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17621
tcaaggaaga uggcau                                                       16


<210> 17622
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17622
gaagauggca uuucu                                                        15


<210> 17623
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17623
tcaaggaaga uggcauuucu a                                                 21


<210> 17624
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17624
tcaaggaaga uggcauuuc                                                    19


<210> 17625
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17625
tcaaggaaga uggcauuu                                                     18


<210> 17626
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17626
tcaaggaaga uggcauu                                                      17


<210> 17627
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17627
tcaaggaaga uggca                                                        15


<210> 17628
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17628
tcaaggaaga uggc                                                         14


<210> 17629
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 17629
tcaaggaaga ugg                                                          13


<210> 17630
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 17630
tcaaggaaga ug                                                           12


<210> 17631
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 17631
tcaaggaaga u                                                            11


<210> 17632
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 17632
tcaaggaaga                                                              10


<210> 17633
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 17633
tcaaggaag                                                                9


<210> 17634
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17634
caaggaagau ggcauuucua g                                                 21


<210> 17635
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17635
caaggaagau ggcauuucua                                                   20


<210> 17636
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17636
caaggaagau ggcauuucu                                                    19


<210> 17637
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17637
caaggaagau ggcauuuc                                                     18


<210> 17638
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17638
caaggaagau ggcauuu                                                      17


<210> 17639
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17639
caaggaagau ggcauu                                                       16


<210> 17640
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17640
caaggaagau ggcau                                                        15


<210> 17641
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17641
caaggaagau ggca                                                         14


<210> 17642
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17642
caaggaagau ggc                                                          13


<210> 17643
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17643
caaggaagau gg                                                           12


<210> 17644
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17644
caaggaagau g                                                            11


<210> 17645
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17645
caaggaagau                                                              10


<210> 17646
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17646
caaggaaga                                                                9


<210> 17647
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17647
caaggaag                                                                 8


<210> 17648
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17648
aaggaagaug gcauuucuag                                                   20


<210> 17649
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17649
aaggaagaug gcauuucua                                                    19


<210> 17650
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17650
aaggaagaug gcauuucu                                                     18


<210> 17651
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17651
aaggaagaug gcauuuc                                                      17


<210> 17652
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17652
aaggaagaug gcauuu                                                       16


<210> 17653
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17653
aaggaagaug gcauu                                                        15


<210> 17654
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17654
aaggaagaug gcau                                                         14


<210> 17655
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17655
aaggaagaug gca                                                          13


<210> 17656
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17656
aaggaagaug gc                                                           12


<210> 17657
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17657
aaggaagaug g                                                            11


<210> 17658
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17658
aaggaagaug                                                              10


<210> 17659
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17659
aaggaagau                                                                9


<210> 17660
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17660
aaggaaga                                                                 8


<210> 17661
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17661
aggaagaugg cauuucuag                                                    19


<210> 17662
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17662
aggaagaugg cauuucua                                                     18


<210> 17663
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17663
aggaagaugg cauuucu                                                      17


<210> 17664
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17664
aggaagaugg cauuuc                                                       16


<210> 17665
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17665
aggaagaugg cauuu                                                        15


<210> 17666
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17666
aggaagaugg cauu                                                         14


<210> 17667
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17667
aggaagaugg cau                                                          13


<210> 17668
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17668
aggaagaugg ca                                                           12


<210> 17669
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17669
aggaagaugg                                                              10


<210> 17670
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17670
aggaagaug                                                                9


<210> 17671
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17671
aggaagau                                                                 8


<210> 17672
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17672
ggaagauggc auuucuag                                                     18


<210> 17673
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17673
ggaagauggc auuucua                                                      17


<210> 17674
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17674
ggaagauggc auuucu                                                       16


<210> 17675
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17675
ggaagauggc auuuc                                                        15


<210> 17676
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17676
ggaagauggc auuu                                                         14


<210> 17677
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17677
ggaagauggc auu                                                          13


<210> 17678
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17678
ggaagauggc au                                                           12


<210> 17679
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17679
ggaagauggc a                                                            11


<210> 17680
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17680
ggaagauggc                                                              10


<210> 17681
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17681
ggaagaug                                                                 8


<210> 17682
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17682
gaagauggca uuucuag                                                      17


<210> 17683
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17683
gaagauggca uuucua                                                       16


<210> 17684
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17684
gaagauggca uuuc                                                         14


<210> 17685
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17685
gaagauggca uuu                                                          13


<210> 17686
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17686
gaagauggca uu                                                           12


<210> 17687
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17687
gaagauggca u                                                            11


<210> 17688
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17688
gaagauggca                                                              10


<210> 17689
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17689
gaagauggc                                                                9


<210> 17690
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17690
gaagaugg                                                                 8


<210> 17691
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17691
aagauggcau uucuag                                                       16


<210> 17692
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17692
aagauggcau uucua                                                        15


<210> 17693
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17693
aagauggcau uucu                                                         14


<210> 17694
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17694
aagauggcau uuc                                                          13


<210> 17695
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17695
aagauggcau uu                                                           12


<210> 17696
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17696
aagauggcau u                                                            11


<210> 17697
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17697
aagauggcau                                                              10


<210> 17698
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17698
aagauggca                                                                9


<210> 17699
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17699
aagauggc                                                                 8


<210> 17700
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17700
agauggcauu ucuag                                                        15


<210> 17701
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17701
agauggcauu ucua                                                         14


<210> 17702
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17702
agauggcauu ucu                                                          13


<210> 17703
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17703
agauggcauu uc                                                           12


<210> 17704
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17704
agauggcauu u                                                            11


<210> 17705
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17705
agauggcauu                                                              10


<210> 17706
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17706
agauggcau                                                                9


<210> 17707
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17707
agauggca                                                                 8


<210> 17708
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 17708
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 17709
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 17709
ctccaacauc aaggaagaug gcauuucua                                         29


<210> 17710
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 17710
ctccaacauc aaggaagaug gcauuucu                                          28


<210> 17711
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 17711
ctccaacauc aaggaagaug gcauuuc                                           27


<210> 17712
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 17712
ctccaacauc aaggaagaug gcauuu                                            26


<210> 17713
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 17713
ctccaacauc aaggaagaug gcauu                                             25


<210> 17714
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 17714
ctccaacauc aaggaagaug gcau                                              24


<210> 17715
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 17715
ctccaacauc aaggaagaug gca                                               23


<210> 17716
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 17716
ctccaacauc aaggaagaug gc                                                22


<210> 17717
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17717
ctccaacauc aaggaagaug g                                                 21


<210> 17718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17718
ctccaacauc aaggaagaug                                                   20


<210> 17719
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17719
ctccaacauc aaggaagau                                                    19


<210> 17720
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17720
ctccaacauc aaggaaga                                                     18


<210> 17721
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17721
ctccaacauc aaggaag                                                      17


<210> 17722
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 17722
tccaacauca aggaagaugg cauuucuag                                         29


<210> 17723
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 17723
tccaacauca aggaagaugg cauuucua                                          28


<210> 17724
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 17724
tccaacauca aggaagaugg cauuucu                                           27


<210> 17725
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 17725
tccaacauca aggaagaugg cauuuc                                            26


<210> 17726
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 17726
tccaacauca aggaagaugg cauuu                                             25


<210> 17727
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 17727
tccaacauca aggaagaugg cauu                                              24


<210> 17728
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 17728
tccaacauca aggaagaugg cau                                               23


<210> 17729
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 17729
tccaacauca aggaagaugg ca                                                22


<210> 17730
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 17730
tccaacauca aggaagaugg c                                                 21


<210> 17731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17731
tccaacauca aggaagaugg                                                   20


<210> 17732
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17732
tccaacauca aggaagaug                                                    19


<210> 17733
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17733
tccaacauca aggaagau                                                     18


<210> 17734
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17734
tccaacauca aggaaga                                                      17


<210> 17735
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17735
tccaacauca aggaag                                                       16


<210> 17736
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 17736
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 17737
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 17737
ccaacaucaa ggaagauggc auuucua                                           27


<210> 17738
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 17738
ccaacaucaa ggaagauggc auuucu                                            26


<210> 17739
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 17739
ccaacaucaa ggaagauggc auuuc                                             25


<210> 17740
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17740
ccaacaucaa ggaagauggc auuu                                              24


<210> 17741
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17741
ccaacaucaa ggaagauggc auu                                               23


<210> 17742
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17742
ccaacaucaa ggaagauggc au                                                22


<210> 17743
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17743
ccaacaucaa ggaagauggc a                                                 21


<210> 17744
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17744
ccaacaucaa ggaagauggc                                                   20


<210> 17745
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17745
ccaacaucaa ggaagaugg                                                    19


<210> 17746
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17746
ccaacaucaa ggaagaug                                                     18


<210> 17747
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17747
ccaacaucaa ggaagau                                                      17


<210> 17748
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17748
ccaacaucaa ggaaga                                                       16


<210> 17749
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17749
ccaacaucaa ggaag                                                        15


<210> 17750
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 17750
caacaucaag gaagauggca uuucuag                                           27


<210> 17751
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 17751
caacaucaag gaagauggca uuucua                                            26


<210> 17752
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 17752
caacaucaag gaagauggca uuucu                                             25


<210> 17753
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 17753
caacaucaag gaagauggca uuuc                                              24


<210> 17754
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17754
caacaucaag gaagauggca uuu                                               23


<210> 17755
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17755
caacaucaag gaagauggca uu                                                22


<210> 17756
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17756
caacaucaag gaagauggca u                                                 21


<210> 17757
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17757
caacaucaag gaagauggca                                                   20


<210> 17758
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17758
caacaucaag gaagauggc                                                    19


<210> 17759
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17759
caacaucaag gaagaugg                                                     18


<210> 17760
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17760
caacaucaag gaagaug                                                      17


<210> 17761
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17761
caacaucaag gaagau                                                       16


<210> 17762
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17762
caacaucaag gaaga                                                        15


<210> 17763
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17763
caacaucaag gaag                                                         14


<210> 17764
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 17764
aacaucaagg aagauggcau uucuag                                            26


<210> 17765
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 17765
aacaucaagg aagauggcau uucua                                             25


<210> 17766
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 17766
aacaucaagg aagauggcau uucu                                              24


<210> 17767
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 17767
aacaucaagg aagauggcau uuc                                               23


<210> 17768
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17768
aacaucaagg aagauggcau uu                                                22


<210> 17769
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17769
aacaucaagg aagauggcau u                                                 21


<210> 17770
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17770
aacaucaagg aagauggcau                                                   20


<210> 17771
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17771
aacaucaagg aagauggca                                                    19


<210> 17772
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17772
aacaucaagg aagauggc                                                     18


<210> 17773
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17773
aacaucaagg aagaugg                                                      17


<210> 17774
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17774
aacaucaagg aagaug                                                       16


<210> 17775
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17775
aacaucaagg aagau                                                        15


<210> 17776
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17776
aacaucaagg aaga                                                         14


<210> 17777
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17777
aacaucaagg aag                                                          13


<210> 17778
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 17778
acaucaagga agauggcauu ucuag                                             25


<210> 17779
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 17779
acaucaagga agauggcauu ucua                                              24


<210> 17780
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 17780
acaucaagga agauggcauu ucu                                               23


<210> 17781
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 17781
acaucaagga agauggcauu uc                                                22


<210> 17782
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17782
acaucaagga agauggcauu u                                                 21


<210> 17783
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17783
acaucaagga agauggcauu                                                   20


<210> 17784
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17784
acaucaagga agauggcau                                                    19


<210> 17785
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17785
acaucaagga agauggca                                                     18


<210> 17786
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17786
acaucaagga agauggc                                                      17


<210> 17787
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 17787
acaucaagga agaugg                                                       16


<210> 17788
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 17788
acaucaagga agaug                                                        15


<210> 17789
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 17789
acaucaagga agau                                                         14


<210> 17790
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 17790
acaucaagga aga                                                          13


<210> 17791
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 17791
acaucaagga ag                                                           12


<210> 17792
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 17792
caucaaggaa gauggcauuu cuag                                              24


<210> 17793
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 17793
caucaaggaa gauggcauuu cua                                               23


<210> 17794
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 17794
caucaaggaa gauggcauuu cu                                                22


<210> 17795
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 17795
caucaaggaa gauggcauuu c                                                 21


<210> 17796
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17796
caucaaggaa gauggcauuu                                                   20


<210> 17797
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17797
caucaaggaa gauggcauu                                                    19


<210> 17798
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17798
caucaaggaa gauggcau                                                     18


<210> 17799
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17799
caucaaggaa gauggca                                                      17


<210> 17800
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17800
caucaaggaa gauggc                                                       16


<210> 17801
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 17801
caucaaggaa gaugg                                                        15


<210> 17802
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 17802
caucaaggaa gaug                                                         14


<210> 17803
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 17803
caucaaggaa gau                                                          13


<210> 17804
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 17804
caucaaggaa ga                                                           12


<210> 17805
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 17805
caucaaggaa g                                                            11


<210> 17806
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17806
atcaaggaag auggcauuuc uag                                               23


<210> 17807
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17807
atcaaggaag auggcauuuc ua                                                22


<210> 17808
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17808
atcaaggaag auggcauuuc u                                                 21


<210> 17809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17809
atcaaggaag auggcauuuc                                                   20


<210> 17810
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17810
atcaaggaag auggcauuu                                                    19


<210> 17811
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17811
atcaaggaag auggcauu                                                     18


<210> 17812
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17812
atcaaggaag auggcau                                                      17


<210> 17813
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17813
atcaaggaag auggca                                                       16


<210> 17814
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17814
atcaaggaag auggc                                                        15


<210> 17815
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 17815
atcaaggaag augg                                                         14


<210> 17816
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 17816
atcaaggaag aug                                                          13


<210> 17817
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 17817
atcaaggaag au                                                           12


<210> 17818
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 17818
atcaaggaag a                                                            11


<210> 17819
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 17819
atcaaggaag                                                              10


<210> 17820
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 17820
ccagagcagg uaccuccaac auc                                               23


<210> 17821
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17821
ccagagcagg uaccucca                                                     18


<210> 17822
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17822
ccucugugau uuuauaacuu gau                                               23


<210> 17823
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17823
tcacccacca ucacccu                                                      17


<210> 17824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17824
tgauauccuc aaggucaccc                                                   20


<210> 17825
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17825
ctgcuugaug aucaucucgu ug                                                22


<210> 17826
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17826
ctgcuugaug aucaucuc                                                     18


<210> 17827
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17827
gtuuccuuag uaaccacag                                                    19


<210> 17828
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17828
gtuuccuuag uaaccac                                                      17


<210> 17829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17829
tcaaggaaga uggcauuucu                                                   20


<210> 17830
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17830
tcaaggaaga uggcauuucu ag                                                22


<210> 17831
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17831
gguaaguucu guccaagc                                                     18


<210> 17832
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17832
gtaaguucug uccaagcc                                                     18


<210> 17833
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17833
agucgguaag uucugucc                                                     18


<210> 17834
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17834
ctguccaagc ccgguuga                                                     18


<210> 17835
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17835
taaguucugu ccaag                                                        15


<210> 17836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17836
ttcuguccaa gcccgguuga                                                   20


<210> 17837
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17837
ttcuguccaa gcccgguug                                                    19


<210> 17838
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17838
ttcuguccaa gcccgguu                                                     18


<210> 17839
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17839
ttcuguccaa gcccggu                                                      17


<210> 17840
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17840
ttcuguccaa gcccgg                                                       16


<210> 17841
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17841
ttcuguccaa gcccg                                                        15


<210> 17842
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17842
ttcuguccaa gccc                                                         14


<210> 17843
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17843
ttcuguccaa gcc                                                          13


<210> 17844
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17844
ttcuguccaa gc                                                           12


<210> 17845
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17845
ttcuguccaa g                                                            11


<210> 17846
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17846
ttcuguccaa                                                              10


<210> 17847
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17847
ttcugucca                                                                9


<210> 17848
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17848
ttcugucc                                                                 8


<210> 17849
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17849
tcuguccaag cccgguuga                                                    19


<210> 17850
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17850
tcuguccaag cccgguug                                                     18


<210> 17851
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17851
tcuguccaag cccgguu                                                      17


<210> 17852
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17852
tcuguccaag cccggu                                                       16


<210> 17853
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17853
tcuguccaag cccgg                                                        15


<210> 17854
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17854
tcuguccaag cccg                                                         14


<210> 17855
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17855
tcuguccaag ccc                                                          13


<210> 17856
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17856
tcuguccaag cc                                                           12


<210> 17857
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17857
tcuguccaag c                                                            11


<210> 17858
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17858
tcuguccaag                                                              10


<210> 17859
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17859
tcuguccaa                                                                9


<210> 17860
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17860
tcugucca                                                                 8


<210> 17861
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17861
ctguccaagc ccgguug                                                      17


<210> 17862
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17862
ctguccaagc ccgguu                                                       16


<210> 17863
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17863
ctguccaagc ccggu                                                        15


<210> 17864
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17864
ctguccaagc ccgg                                                         14


<210> 17865
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17865
ctguccaagc ccg                                                          13


<210> 17866
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17866
ctguccaagc cc                                                           12


<210> 17867
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17867
ctguccaagc c                                                            11


<210> 17868
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17868
ctguccaagc                                                              10


<210> 17869
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17869
ctguccaag                                                                9


<210> 17870
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17870
ctguccaa                                                                 8


<210> 17871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17871
gtucugucca agcccgguug                                                   20


<210> 17872
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17872
gtucugucca agcccgguu                                                    19


<210> 17873
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17873
gtucugucca agcccggu                                                     18


<210> 17874
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17874
gtucugucca agcccgg                                                      17


<210> 17875
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17875
gtucugucca agcccg                                                       16


<210> 17876
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17876
gtucugucca agccc                                                        15


<210> 17877
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17877
gtucugucca agcc                                                         14


<210> 17878
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17878
gtucugucca agc                                                          13


<210> 17879
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17879
gtucugucca ag                                                           12


<210> 17880
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17880
gtucugucca a                                                            11


<210> 17881
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17881
gtucugucca                                                              10


<210> 17882
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17882
gtucugucc                                                                9


<210> 17883
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17883
gtucuguc                                                                 8


<210> 17884
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17884
aguucugucc aagcccgguu                                                   20


<210> 17885
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17885
aguucugucc aagcccggu                                                    19


<210> 17886
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17886
aguucugucc aagcccgg                                                     18


<210> 17887
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17887
aguucugucc aagcccg                                                      17


<210> 17888
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17888
aguucugucc aagccc                                                       16


<210> 17889
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17889
aguucugucc aagcc                                                        15


<210> 17890
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17890
aguucugucc aagc                                                         14


<210> 17891
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17891
aguucugucc aag                                                          13


<210> 17892
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17892
aguucugucc aa                                                           12


<210> 17893
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17893
aguucugucc a                                                            11


<210> 17894
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17894
aguucugucc                                                              10


<210> 17895
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17895
aguucuguc                                                                9


<210> 17896
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 17896
aguucugu                                                                 8


<210> 17897
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17897
aaguucuguc caagcccggu                                                   20


<210> 17898
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17898
aaguucuguc caagcccgg                                                    19


<210> 17899
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17899
aaguucuguc caagcccg                                                     18


<210> 17900
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17900
aaguucuguc caagccc                                                      17


<210> 17901
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17901
aaguucuguc caagcc                                                       16


<210> 17902
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17902
aaguucuguc caagc                                                        15


<210> 17903
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17903
aaguucuguc caag                                                         14


<210> 17904
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17904
aaguucuguc caa                                                          13


<210> 17905
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17905
aaguucuguc ca                                                           12


<210> 17906
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17906
aaguucuguc c                                                            11


<210> 17907
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17907
aaguucuguc                                                              10


<210> 17908
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17908
aaguucugu                                                                9


<210> 17909
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 17909
aaguucug                                                                 8


<210> 17910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17910
taaguucugu ccaagcccgg                                                   20


<210> 17911
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17911
taaguucugu ccaagcccg                                                    19


<210> 17912
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17912
taaguucugu ccaagccc                                                     18


<210> 17913
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17913
taaguucugu ccaagcc                                                      17


<210> 17914
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17914
taaguucugu ccaagc                                                       16


<210> 17915
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17915
taaguucugu ccaa                                                         14


<210> 17916
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17916
taaguucugu cca                                                          13


<210> 17917
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17917
taaguucugu cc                                                           12


<210> 17918
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17918
taaguucugu c                                                            11


<210> 17919
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17919
taaguucugu                                                              10


<210> 17920
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17920
taaguucug                                                                9


<210> 17921
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 17921
taaguucu                                                                 8


<210> 17922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17922
gtaaguucug uccaagcccg                                                   20


<210> 17923
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17923
gtaaguucug uccaagccc                                                    19


<210> 17924
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17924
gtaaguucug uccaagc                                                      17


<210> 17925
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17925
gtaaguucug uccaag                                                       16


<210> 17926
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17926
gtaaguucug uccaa                                                        15


<210> 17927
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17927
gtaaguucug ucca                                                         14


<210> 17928
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17928
gtaaguucug ucc                                                          13


<210> 17929
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17929
gtaaguucug uc                                                           12


<210> 17930
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17930
gtaaguucug u                                                            11


<210> 17931
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17931
gtaaguucug                                                              10


<210> 17932
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17932
gtaaguucu                                                                9


<210> 17933
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 17933
gtaaguuc                                                                 8


<210> 17934
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17934
gguaaguucu guccaagccc                                                   20


<210> 17935
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17935
gguaaguucu guccaagcc                                                    19


<210> 17936
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17936
gguaaguucu guccaag                                                      17


<210> 17937
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17937
gguaaguucu guccaa                                                       16


<210> 17938
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17938
gguaaguucu gucca                                                        15


<210> 17939
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17939
gguaaguucu gucc                                                         14


<210> 17940
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17940
gguaaguucu guc                                                          13


<210> 17941
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17941
gguaaguucu gu                                                           12


<210> 17942
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17942
gguaaguucu g                                                            11


<210> 17943
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17943
gguaaguucu                                                              10


<210> 17944
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 17944
gguaaguuc                                                                9


<210> 17945
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17945
gguaaguu                                                                 8


<210> 17946
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17946
cgguaaguuc uguccaagcc                                                   20


<210> 17947
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17947
cgguaaguuc uguccaagc                                                    19


<210> 17948
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17948
cgguaaguuc uguccaag                                                     18


<210> 17949
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17949
cgguaaguuc uguccaa                                                      17


<210> 17950
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17950
cgguaaguuc ugucca                                                       16


<210> 17951
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17951
cgguaaguuc ugucc                                                        15


<210> 17952
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17952
cgguaaguuc uguc                                                         14


<210> 17953
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17953
cgguaaguuc ugu                                                          13


<210> 17954
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17954
cgguaaguuc ug                                                           12


<210> 17955
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17955
cgguaaguuc u                                                            11


<210> 17956
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 17956
cgguaaguuc                                                              10


<210> 17957
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17957
cgguaaguu                                                                9


<210> 17958
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 17958
cgguaagu                                                                 8


<210> 17959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 17959
tcgguaaguu cuguccaagc                                                   20


<210> 17960
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17960
tcgguaaguu cuguccaag                                                    19


<210> 17961
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17961
tcgguaaguu cuguccaa                                                     18


<210> 17962
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17962
tcgguaaguu cugucca                                                      17


<210> 17963
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17963
tcgguaaguu cugucc                                                       16


<210> 17964
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 17964
tcgguaaguu cuguc                                                        15


<210> 17965
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17965
tcgguaaguu cugu                                                         14


<210> 17966
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17966
tcgguaaguu cug                                                          13


<210> 17967
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17967
tcgguaaguu cu                                                           12


<210> 17968
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 17968
tcgguaaguu c                                                            11


<210> 17969
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 17969
tcgguaaguu                                                              10


<210> 17970
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 17970
tcgguaagu                                                                9


<210> 17971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17971
gtcgguaagu ucuguccaag                                                   20


<210> 17972
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17972
gtcgguaagu ucuguccaa                                                    19


<210> 17973
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17973
gtcgguaagu ucugucca                                                     18


<210> 17974
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17974
gtcgguaagu ucugucc                                                      17


<210> 17975
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 17975
gtcgguaagu ucuguc                                                       16


<210> 17976
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17976
gtcgguaagu ucugu                                                        15


<210> 17977
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17977
gtcgguaagu ucug                                                         14


<210> 17978
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17978
gtcgguaagu ucu                                                          13


<210> 17979
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 17979
gtcgguaagu uc                                                           12


<210> 17980
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 17980
gtcgguaagu u                                                            11


<210> 17981
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 17981
gtcgguaagu                                                              10


<210> 17982
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17982
agucgguaag uucuguccaa                                                   20


<210> 17983
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17983
agucgguaag uucugucca                                                    19


<210> 17984
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 17984
agucgguaag uucuguc                                                      17


<210> 17985
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17985
agucgguaag uucugu                                                       16


<210> 17986
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17986
agucgguaag uucug                                                        15


<210> 17987
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17987
agucgguaag uucu                                                         14


<210> 17988
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 17988
agucgguaag uuc                                                          13


<210> 17989
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 17989
agucgguaag uu                                                           12


<210> 17990
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 17990
agucgguaag u                                                            11


<210> 17991
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17991
cagucgguaa guucugucca                                                   20


<210> 17992
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 17992
cagucgguaa guucugucc                                                    19


<210> 17993
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 17993
cagucgguaa guucuguc                                                     18


<210> 17994
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17994
cagucgguaa guucugu                                                      17


<210> 17995
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17995
cagucgguaa guucug                                                       16


<210> 17996
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17996
cagucgguaa guucu                                                        15


<210> 17997
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 17997
cagucgguaa guuc                                                         14


<210> 17998
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 17998
cagucgguaa guu                                                          13


<210> 17999
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 17999
cagucgguaa gu                                                           12


<210> 18000
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18000
ccagucggua aguucugucc                                                   20


<210> 18001
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 18001
ccagucggua aguucuguc                                                    19


<210> 18002
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18002
ccagucggua aguucugu                                                     18


<210> 18003
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18003
ccagucggua aguucug                                                      17


<210> 18004
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18004
ccagucggua aguucu                                                       16


<210> 18005
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18005
ccagucggua aguuc                                                        15


<210> 18006
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 18006
ccagucggua aguu                                                         14


<210> 18007
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 18007
ccagucggua agu                                                          13


<210> 18008
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18008
gccagucggu aaguucuguc                                                   20


<210> 18009
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18009
gccagucggu aaguucugu                                                    19


<210> 18010
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18010
gccagucggu aaguucug                                                     18


<210> 18011
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18011
gccagucggu aaguucu                                                      17


<210> 18012
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18012
gccagucggu aaguuc                                                       16


<210> 18013
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 18013
gccagucggu aaguu                                                        15


<210> 18014
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 18014
gccagucggu aagu                                                         14


<210> 18015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 18015
tcaaggaaga uggcauuucu                                                   20


<210> 18016
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 18016
tcaaggaaga uggcauuucu ag                                                22


<210> 18017
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 18017
tcaaggaaga uggcau                                                       16


<210> 18018
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 18018
gaagauggca uuucu                                                        15


<210> 18019
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 18019
tcaaggaaga uggcauuucu a                                                 21


<210> 18020
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 18020
tcaaggaaga uggcauuuc                                                    19


<210> 18021
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 18021
tcaaggaaga uggcauuu                                                     18


<210> 18022
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 18022
tcaaggaaga uggcauu                                                      17


<210> 18023
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 18023
tcaaggaaga uggca                                                        15


<210> 18024
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 18024
tcaaggaaga uggc                                                         14


<210> 18025
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 18025
tcaaggaaga ugg                                                          13


<210> 18026
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 18026
tcaaggaaga ug                                                           12


<210> 18027
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 18027
tcaaggaaga u                                                            11


<210> 18028
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 18028
tcaaggaaga                                                              10


<210> 18029
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<400> 18029
tcaaggaag                                                                9


<210> 18030
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18030
caaggaagau ggcauuucua g                                                 21


<210> 18031
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18031
caaggaagau ggcauuucua                                                   20


<210> 18032
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18032
caaggaagau ggcauuucu                                                    19


<210> 18033
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18033
caaggaagau ggcauuuc                                                     18


<210> 18034
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 18034
caaggaagau ggcauuu                                                      17


<210> 18035
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 18035
caaggaagau ggcauu                                                       16


<210> 18036
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 18036
caaggaagau ggcau                                                        15


<210> 18037
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 18037
caaggaagau ggca                                                         14


<210> 18038
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 18038
caaggaagau ggc                                                          13


<210> 18039
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18039
caaggaagau gg                                                           12


<210> 18040
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18040
caaggaagau g                                                            11


<210> 18041
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18041
caaggaagau                                                              10


<210> 18042
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18042
caaggaaga                                                                9


<210> 18043
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18043
caaggaag                                                                 8


<210> 18044
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18044
aaggaagaug gcauuucuag                                                   20


<210> 18045
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18045
aaggaagaug gcauuucua                                                    19


<210> 18046
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18046
aaggaagaug gcauuucu                                                     18


<210> 18047
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18047
aaggaagaug gcauuuc                                                      17


<210> 18048
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 18048
aaggaagaug gcauuu                                                       16


<210> 18049
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 18049
aaggaagaug gcauu                                                        15


<210> 18050
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 18050
aaggaagaug gcau                                                         14


<210> 18051
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 18051
aaggaagaug gca                                                          13


<210> 18052
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 18052
aaggaagaug gc                                                           12


<210> 18053
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18053
aaggaagaug g                                                            11


<210> 18054
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18054
aaggaagaug                                                              10


<210> 18055
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18055
aaggaagau                                                                9


<210> 18056
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18056
aaggaaga                                                                 8


<210> 18057
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18057
aggaagaugg cauuucuag                                                    19


<210> 18058
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18058
aggaagaugg cauuucua                                                     18


<210> 18059
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18059
aggaagaugg cauuucu                                                      17


<210> 18060
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18060
aggaagaugg cauuuc                                                       16


<210> 18061
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 18061
aggaagaugg cauuu                                                        15


<210> 18062
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 18062
aggaagaugg cauu                                                         14


<210> 18063
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 18063
aggaagaugg cau                                                          13


<210> 18064
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<400> 18064
aggaagaugg ca                                                           12


<210> 18065
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18065
aggaagaugg                                                              10


<210> 18066
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18066
aggaagaug                                                                9


<210> 18067
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18067
aggaagau                                                                 8


<210> 18068
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18068
ggaagauggc auuucuag                                                     18


<210> 18069
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18069
ggaagauggc auuucua                                                      17


<210> 18070
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18070
ggaagauggc auuucu                                                       16


<210> 18071
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18071
ggaagauggc auuuc                                                        15


<210> 18072
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 18072
ggaagauggc auuu                                                         14


<210> 18073
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 18073
ggaagauggc auu                                                          13


<210> 18074
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 18074
ggaagauggc au                                                           12


<210> 18075
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 18075
ggaagauggc a                                                            11


<210> 18076
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 18076
ggaagauggc                                                              10


<210> 18077
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18077
ggaagaug                                                                 8


<210> 18078
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 18078
gaagauggca uuucuag                                                      17


<210> 18079
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 18079
gaagauggca uuucua                                                       16


<210> 18080
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 18080
gaagauggca uuuc                                                         14


<210> 18081
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 18081
gaagauggca uuu                                                          13


<210> 18082
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 18082
gaagauggca uu                                                           12


<210> 18083
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 18083
gaagauggca u                                                            11


<210> 18084
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 18084
gaagauggca                                                              10


<210> 18085
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 18085
gaagauggc                                                                9


<210> 18086
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 18086
gaagaugg                                                                 8


<210> 18087
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 18087
aagauggcau uucuag                                                       16


<210> 18088
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 18088
aagauggcau uucua                                                        15


<210> 18089
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 18089
aagauggcau uucu                                                         14


<210> 18090
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<400> 18090
aagauggcau uuc                                                          13


<210> 18091
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 18091
aagauggcau uu                                                           12


<210> 18092
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 18092
aagauggcau u                                                            11


<210> 18093
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 18093
aagauggcau                                                              10


<210> 18094
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 18094
aagauggca                                                                9


<210> 18095
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 18095
aagauggc                                                                 8


<210> 18096
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 18096
agauggcauu ucuag                                                        15


<210> 18097
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 18097
agauggcauu ucua                                                         14


<210> 18098
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 18098
agauggcauu ucu                                                          13


<210> 18099
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<400> 18099
agauggcauu uc                                                           12


<210> 18100
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 18100
agauggcauu u                                                            11


<210> 18101
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 18101
agauggcauu                                                              10


<210> 18102
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 18102
agauggcau                                                                9


<210> 18103
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 18103
agauggca                                                                 8


<210> 18104
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 18104
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 18105
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 18105
ctccaacauc aaggaagaug gcauuucua                                         29


<210> 18106
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 18106
ctccaacauc aaggaagaug gcauuucu                                          28


<210> 18107
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<400> 18107
ctccaacauc aaggaagaug gcauuuc                                           27


<210> 18108
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 18108
ctccaacauc aaggaagaug gcauuu                                            26


<210> 18109
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 18109
ctccaacauc aaggaagaug gcauu                                             25


<210> 18110
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 18110
ctccaacauc aaggaagaug gcau                                              24


<210> 18111
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 18111
ctccaacauc aaggaagaug gca                                               23


<210> 18112
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 18112
ctccaacauc aaggaagaug gc                                                22


<210> 18113
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 18113
ctccaacauc aaggaagaug g                                                 21


<210> 18114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 18114
ctccaacauc aaggaagaug                                                   20


<210> 18115
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 18115
ctccaacauc aaggaagau                                                    19


<210> 18116
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 18116
ctccaacauc aaggaaga                                                     18


<210> 18117
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<400> 18117
ctccaacauc aaggaag                                                      17


<210> 18118
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 18118
tccaacauca aggaagaugg cauuucuag                                         29


<210> 18119
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 18119
tccaacauca aggaagaugg cauuucua                                          28


<210> 18120
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 18120
tccaacauca aggaagaugg cauuucu                                           27


<210> 18121
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<400> 18121
tccaacauca aggaagaugg cauuuc                                            26


<210> 18122
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 18122
tccaacauca aggaagaugg cauuu                                             25


<210> 18123
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 18123
tccaacauca aggaagaugg cauu                                              24


<210> 18124
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 18124
tccaacauca aggaagaugg cau                                               23


<210> 18125
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 18125
tccaacauca aggaagaugg ca                                                22


<210> 18126
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 18126
tccaacauca aggaagaugg c                                                 21


<210> 18127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 18127
tccaacauca aggaagaugg                                                   20


<210> 18128
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 18128
tccaacauca aggaagaug                                                    19


<210> 18129
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 18129
tccaacauca aggaagau                                                     18


<210> 18130
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 18130
tccaacauca aggaaga                                                      17


<210> 18131
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<400> 18131
tccaacauca aggaag                                                       16


<210> 18132
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 18132
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 18133
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 18133
ccaacaucaa ggaagauggc auuucua                                           27


<210> 18134
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 18134
ccaacaucaa ggaagauggc auuucu                                            26


<210> 18135
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<400> 18135
ccaacaucaa ggaagauggc auuuc                                             25


<210> 18136
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18136
ccaacaucaa ggaagauggc auuu                                              24


<210> 18137
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18137
ccaacaucaa ggaagauggc auu                                               23


<210> 18138
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18138
ccaacaucaa ggaagauggc au                                                22


<210> 18139
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18139
ccaacaucaa ggaagauggc a                                                 21


<210> 18140
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18140
ccaacaucaa ggaagauggc                                                   20


<210> 18141
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 18141
ccaacaucaa ggaagaugg                                                    19


<210> 18142
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 18142
ccaacaucaa ggaagaug                                                     18


<210> 18143
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 18143
ccaacaucaa ggaagau                                                      17


<210> 18144
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 18144
ccaacaucaa ggaaga                                                       16


<210> 18145
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<400> 18145
ccaacaucaa ggaag                                                        15


<210> 18146
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 18146
caacaucaag gaagauggca uuucuag                                           27


<210> 18147
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 18147
caacaucaag gaagauggca uuucua                                            26


<210> 18148
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 18148
caacaucaag gaagauggca uuucu                                             25


<210> 18149
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<400> 18149
caacaucaag gaagauggca uuuc                                              24


<210> 18150
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 18150
caacaucaag gaagauggca uuu                                               23


<210> 18151
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 18151
caacaucaag gaagauggca uu                                                22


<210> 18152
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 18152
caacaucaag gaagauggca u                                                 21


<210> 18153
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 18153
caacaucaag gaagauggca                                                   20


<210> 18154
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 18154
caacaucaag gaagauggc                                                    19


<210> 18155
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 18155
caacaucaag gaagaugg                                                     18


<210> 18156
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 18156
caacaucaag gaagaug                                                      17


<210> 18157
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 18157
caacaucaag gaagau                                                       16


<210> 18158
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 18158
caacaucaag gaaga                                                        15


<210> 18159
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<400> 18159
caacaucaag gaag                                                         14


<210> 18160
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 18160
aacaucaagg aagauggcau uucuag                                            26


<210> 18161
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 18161
aacaucaagg aagauggcau uucua                                             25


<210> 18162
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 18162
aacaucaagg aagauggcau uucu                                              24


<210> 18163
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 18163
aacaucaagg aagauggcau uuc                                               23


<210> 18164
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18164
aacaucaagg aagauggcau uu                                                22


<210> 18165
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18165
aacaucaagg aagauggcau u                                                 21


<210> 18166
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18166
aacaucaagg aagauggcau                                                   20


<210> 18167
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18167
aacaucaagg aagauggca                                                    19


<210> 18168
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18168
aacaucaagg aagauggc                                                     18


<210> 18169
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 18169
aacaucaagg aagaugg                                                      17


<210> 18170
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 18170
aacaucaagg aagaug                                                       16


<210> 18171
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 18171
aacaucaagg aagau                                                        15


<210> 18172
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 18172
aacaucaagg aaga                                                         14


<210> 18173
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<400> 18173
aacaucaagg aag                                                          13


<210> 18174
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 18174
acaucaagga agauggcauu ucuag                                             25


<210> 18175
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 18175
acaucaagga agauggcauu ucua                                              24


<210> 18176
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 18176
acaucaagga agauggcauu ucu                                               23


<210> 18177
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<400> 18177
acaucaagga agauggcauu uc                                                22


<210> 18178
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18178
acaucaagga agauggcauu u                                                 21


<210> 18179
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18179
acaucaagga agauggcauu                                                   20


<210> 18180
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18180
acaucaagga agauggcau                                                    19


<210> 18181
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18181
acaucaagga agauggca                                                     18


<210> 18182
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18182
acaucaagga agauggc                                                      17


<210> 18183
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 18183
acaucaagga agaugg                                                       16


<210> 18184
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 18184
acaucaagga agaug                                                        15


<210> 18185
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 18185
acaucaagga agau                                                         14


<210> 18186
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 18186
acaucaagga aga                                                          13


<210> 18187
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<400> 18187
acaucaagga ag                                                           12


<210> 18188
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 18188
caucaaggaa gauggcauuu cuag                                              24


<210> 18189
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 18189
caucaaggaa gauggcauuu cua                                               23


<210> 18190
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 18190
caucaaggaa gauggcauuu cu                                                22


<210> 18191
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<400> 18191
caucaaggaa gauggcauuu c                                                 21


<210> 18192
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18192
caucaaggaa gauggcauuu                                                   20


<210> 18193
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18193
caucaaggaa gauggcauu                                                    19


<210> 18194
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18194
caucaaggaa gauggcau                                                     18


<210> 18195
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18195
caucaaggaa gauggca                                                      17


<210> 18196
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18196
caucaaggaa gauggc                                                       16


<210> 18197
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 18197
caucaaggaa gaugg                                                        15


<210> 18198
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 18198
caucaaggaa gaug                                                         14


<210> 18199
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 18199
caucaaggaa gau                                                          13


<210> 18200
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 18200
caucaaggaa ga                                                           12


<210> 18201
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<400> 18201
caucaaggaa g                                                            11


<210> 18202
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18202
atcaaggaag auggcauuuc uag                                               23


<210> 18203
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18203
atcaaggaag auggcauuuc ua                                                22


<210> 18204
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18204
atcaaggaag auggcauuuc u                                                 21


<210> 18205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18205
atcaaggaag auggcauuuc                                                   20


<210> 18206
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18206
atcaaggaag auggcauuu                                                    19


<210> 18207
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18207
atcaaggaag auggcauu                                                     18


<210> 18208
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18208
atcaaggaag auggcau                                                      17


<210> 18209
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18209
atcaaggaag auggca                                                       16


<210> 18210
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<400> 18210
atcaaggaag auggc                                                        15


<210> 18211
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 18211
atcaaggaag augg                                                         14


<210> 18212
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 18212
atcaaggaag aug                                                          13


<210> 18213
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 18213
atcaaggaag au                                                           12


<210> 18214
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 18214
atcaaggaag a                                                            11


<210> 18215
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<400> 18215
atcaaggaag                                                              10


<210> 18216
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<400> 18216
ccagagcagg uaccuccaac auc                                               23


<210> 18217
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18217
ccagagcagg uaccucca                                                     18


<210> 18218
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18218
ccucugugau uuuauaacuu gau                                               23


<210> 18219
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<400> 18219
tcacccacca ucacccu                                                      17


<210> 18220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<400> 18220
tgauauccuc aaggucaccc                                                   20


<210> 18221
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18221
ctgcuugaug aucaucucgu ug                                                22


<210> 18222
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<400> 18222
ctgcuugaug aucaucuc                                                     18


<210> 18223
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18223
gtuuccuuag uaaccacag                                                    19


<210> 18224
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<400> 18224
gtuuccuuag uaaccac                                                      17


<210> 18225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18225
tcaaggaaga uggcauuucu                                                   20


<210> 18226
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18226
tcaaggaaga uggcauuucu ag                                                22


<210> 18227
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18227
gguaaguucu guccaagc                                                     18


<210> 18228
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18228
gtaaguucug uccaagcc                                                     18


<210> 18229
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18229
agucgguaag uucugucc                                                     18


<210> 18230
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18230
ctguccaagc ccgguuga                                                     18


<210> 18231
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18231
taaguucugu ccaag                                                        15


<210> 18232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18232
ttcuguccaa gcccgguuga                                                   20


<210> 18233
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18233
ttcuguccaa gcccgguug                                                    19


<210> 18234
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18234
ttcuguccaa gcccgguu                                                     18


<210> 18235
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18235
ttcuguccaa gcccggu                                                      17


<210> 18236
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18236
ttcuguccaa gcccgg                                                       16


<210> 18237
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18237
ttcuguccaa gcccg                                                        15


<210> 18238
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18238
ttcuguccaa gccc                                                         14


<210> 18239
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18239
ttcuguccaa gcc                                                          13


<210> 18240
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18240
ttcuguccaa gc                                                           12


<210> 18241
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18241
ttcuguccaa g                                                            11


<210> 18242
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18242
ttcuguccaa                                                              10


<210> 18243
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18243
ttcugucca                                                                9


<210> 18244
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18244
ttcugucc                                                                 8


<210> 18245
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18245
tcuguccaag cccgguuga                                                    19


<210> 18246
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18246
tcuguccaag cccgguug                                                     18


<210> 18247
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18247
tcuguccaag cccgguu                                                      17


<210> 18248
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18248
tcuguccaag cccggu                                                       16


<210> 18249
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18249
tcuguccaag cccgg                                                        15


<210> 18250
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18250
tcuguccaag cccg                                                         14


<210> 18251
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18251
tcuguccaag ccc                                                          13


<210> 18252
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18252
tcuguccaag cc                                                           12


<210> 18253
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18253
tcuguccaag c                                                            11


<210> 18254
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18254
tcuguccaag                                                              10


<210> 18255
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18255
tcuguccaa                                                                9


<210> 18256
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18256
tcugucca                                                                 8


<210> 18257
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18257
ctguccaagc ccgguug                                                      17


<210> 18258
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18258
ctguccaagc ccgguu                                                       16


<210> 18259
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18259
ctguccaagc ccggu                                                        15


<210> 18260
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18260
ctguccaagc ccgg                                                         14


<210> 18261
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18261
ctguccaagc ccg                                                          13


<210> 18262
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18262
ctguccaagc cc                                                           12


<210> 18263
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18263
ctguccaagc c                                                            11


<210> 18264
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18264
ctguccaagc                                                              10


<210> 18265
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18265
ctguccaag                                                                9


<210> 18266
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18266
ctguccaa                                                                 8


<210> 18267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18267
gtucugucca agcccgguug                                                   20


<210> 18268
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18268
gtucugucca agcccgguu                                                    19


<210> 18269
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18269
gtucugucca agcccggu                                                     18


<210> 18270
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18270
gtucugucca agcccgg                                                      17


<210> 18271
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18271
gtucugucca agcccg                                                       16


<210> 18272
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18272
gtucugucca agccc                                                        15


<210> 18273
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18273
gtucugucca agcc                                                         14


<210> 18274
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18274
gtucugucca agc                                                          13


<210> 18275
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18275
gtucugucca ag                                                           12


<210> 18276
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18276
gtucugucca a                                                            11


<210> 18277
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18277
gtucugucca                                                              10


<210> 18278
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18278
gtucugucc                                                                9


<210> 18279
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18279
gtucuguc                                                                 8


<210> 18280
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18280
aguucugucc aagcccgguu                                                   20


<210> 18281
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18281
aguucugucc aagcccggu                                                    19


<210> 18282
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18282
aguucugucc aagcccgg                                                     18


<210> 18283
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18283
aguucugucc aagcccg                                                      17


<210> 18284
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18284
aguucugucc aagccc                                                       16


<210> 18285
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18285
aguucugucc aagcc                                                        15


<210> 18286
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18286
aguucugucc aagc                                                         14


<210> 18287
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18287
aguucugucc aag                                                          13


<210> 18288
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18288
aguucugucc aa                                                           12


<210> 18289
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18289
aguucugucc a                                                            11


<210> 18290
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18290
aguucugucc                                                              10


<210> 18291
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18291
aguucuguc                                                                9


<210> 18292
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18292
aguucugu                                                                 8


<210> 18293
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18293
aaguucuguc caagcccggu                                                   20


<210> 18294
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18294
aaguucuguc caagcccgg                                                    19


<210> 18295
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18295
aaguucuguc caagcccg                                                     18


<210> 18296
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18296
aaguucuguc caagccc                                                      17


<210> 18297
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18297
aaguucuguc caagcc                                                       16


<210> 18298
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18298
aaguucuguc caagc                                                        15


<210> 18299
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18299
aaguucuguc caag                                                         14


<210> 18300
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18300
aaguucuguc caa                                                          13


<210> 18301
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18301
aaguucuguc ca                                                           12


<210> 18302
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18302
aaguucuguc c                                                            11


<210> 18303
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18303
aaguucuguc                                                              10


<210> 18304
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18304
aaguucugu                                                                9


<210> 18305
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18305
aaguucug                                                                 8


<210> 18306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18306
taaguucugu ccaagcccgg                                                   20


<210> 18307
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18307
taaguucugu ccaagcccg                                                    19


<210> 18308
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18308
taaguucugu ccaagccc                                                     18


<210> 18309
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18309
taaguucugu ccaagcc                                                      17


<210> 18310
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18310
taaguucugu ccaagc                                                       16


<210> 18311
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18311
taaguucugu ccaa                                                         14


<210> 18312
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18312
taaguucugu cca                                                          13


<210> 18313
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18313
taaguucugu cc                                                           12


<210> 18314
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18314
taaguucugu c                                                            11


<210> 18315
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18315
taaguucugu                                                              10


<210> 18316
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18316
taaguucug                                                                9


<210> 18317
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18317
taaguucu                                                                 8


<210> 18318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18318
gtaaguucug uccaagcccg                                                   20


<210> 18319
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18319
gtaaguucug uccaagccc                                                    19


<210> 18320
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18320
gtaaguucug uccaagc                                                      17


<210> 18321
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18321
gtaaguucug uccaag                                                       16


<210> 18322
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18322
gtaaguucug uccaa                                                        15


<210> 18323
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18323
gtaaguucug ucca                                                         14


<210> 18324
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18324
gtaaguucug ucc                                                          13


<210> 18325
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18325
gtaaguucug uc                                                           12


<210> 18326
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18326
gtaaguucug u                                                            11


<210> 18327
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18327
gtaaguucug                                                              10


<210> 18328
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18328
gtaaguucu                                                                9


<210> 18329
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18329
gtaaguuc                                                                 8


<210> 18330
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18330
gguaaguucu guccaagccc                                                   20


<210> 18331
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18331
gguaaguucu guccaagcc                                                    19


<210> 18332
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18332
gguaaguucu guccaag                                                      17


<210> 18333
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18333
gguaaguucu guccaa                                                       16


<210> 18334
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18334
gguaaguucu gucca                                                        15


<210> 18335
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18335
gguaaguucu gucc                                                         14


<210> 18336
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18336
gguaaguucu guc                                                          13


<210> 18337
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18337
gguaaguucu gu                                                           12


<210> 18338
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18338
gguaaguucu g                                                            11


<210> 18339
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18339
gguaaguucu                                                              10


<210> 18340
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18340
gguaaguuc                                                                9


<210> 18341
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18341
gguaaguu                                                                 8


<210> 18342
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18342
cgguaaguuc uguccaagcc                                                   20


<210> 18343
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18343
cgguaaguuc uguccaagc                                                    19


<210> 18344
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18344
cgguaaguuc uguccaag                                                     18


<210> 18345
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18345
cgguaaguuc uguccaa                                                      17


<210> 18346
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18346
cgguaaguuc ugucca                                                       16


<210> 18347
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18347
cgguaaguuc ugucc                                                        15


<210> 18348
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18348
cgguaaguuc uguc                                                         14


<210> 18349
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18349
cgguaaguuc ugu                                                          13


<210> 18350
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18350
cgguaaguuc ug                                                           12


<210> 18351
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18351
cgguaaguuc u                                                            11


<210> 18352
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18352
cgguaaguuc                                                              10


<210> 18353
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18353
cgguaaguu                                                                9


<210> 18354
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18354
cgguaagu                                                                 8


<210> 18355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18355
tcgguaaguu cuguccaagc                                                   20


<210> 18356
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18356
tcgguaaguu cuguccaag                                                    19


<210> 18357
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18357
tcgguaaguu cuguccaa                                                     18


<210> 18358
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18358
tcgguaaguu cugucca                                                      17


<210> 18359
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18359
tcgguaaguu cugucc                                                       16


<210> 18360
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18360
tcgguaaguu cuguc                                                        15


<210> 18361
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18361
tcgguaaguu cugu                                                         14


<210> 18362
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18362
tcgguaaguu cug                                                          13


<210> 18363
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18363
tcgguaaguu cu                                                           12


<210> 18364
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18364
tcgguaaguu c                                                            11


<210> 18365
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18365
tcgguaaguu                                                              10


<210> 18366
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18366
tcgguaagu                                                                9


<210> 18367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18367
gtcgguaagu ucuguccaag                                                   20


<210> 18368
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18368
gtcgguaagu ucuguccaa                                                    19


<210> 18369
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18369
gtcgguaagu ucugucca                                                     18


<210> 18370
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18370
gtcgguaagu ucugucc                                                      17


<210> 18371
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18371
gtcgguaagu ucuguc                                                       16


<210> 18372
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18372
gtcgguaagu ucugu                                                        15


<210> 18373
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18373
gtcgguaagu ucug                                                         14


<210> 18374
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18374
gtcgguaagu ucu                                                          13


<210> 18375
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18375
gtcgguaagu uc                                                           12


<210> 18376
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18376
gtcgguaagu u                                                            11


<210> 18377
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18377
gtcgguaagu                                                              10


<210> 18378
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18378
agucgguaag uucuguccaa                                                   20


<210> 18379
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18379
agucgguaag uucugucca                                                    19


<210> 18380
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18380
agucgguaag uucuguc                                                      17


<210> 18381
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18381
agucgguaag uucugu                                                       16


<210> 18382
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18382
agucgguaag uucug                                                        15


<210> 18383
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18383
agucgguaag uucu                                                         14


<210> 18384
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18384
agucgguaag uuc                                                          13


<210> 18385
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18385
agucgguaag uu                                                           12


<210> 18386
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18386
agucgguaag u                                                            11


<210> 18387
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18387
cagucgguaa guucugucca                                                   20


<210> 18388
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18388
cagucgguaa guucugucc                                                    19


<210> 18389
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18389
cagucgguaa guucuguc                                                     18


<210> 18390
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18390
cagucgguaa guucugu                                                      17


<210> 18391
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18391
cagucgguaa guucug                                                       16


<210> 18392
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18392
cagucgguaa guucu                                                        15


<210> 18393
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18393
cagucgguaa guuc                                                         14


<210> 18394
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18394
cagucgguaa guu                                                          13


<210> 18395
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18395
cagucgguaa gu                                                           12


<210> 18396
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18396
ccagucggua aguucugucc                                                   20


<210> 18397
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18397
ccagucggua aguucuguc                                                    19


<210> 18398
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18398
ccagucggua aguucugu                                                     18


<210> 18399
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18399
ccagucggua aguucug                                                      17


<210> 18400
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18400
ccagucggua aguucu                                                       16


<210> 18401
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18401
ccagucggua aguuc                                                        15


<210> 18402
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18402
ccagucggua aguu                                                         14


<210> 18403
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18403
ccagucggua agu                                                          13


<210> 18404
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18404
gccagucggu aaguucuguc                                                   20


<210> 18405
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18405
gccagucggu aaguucugu                                                    19


<210> 18406
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18406
gccagucggu aaguucug                                                     18


<210> 18407
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18407
gccagucggu aaguucu                                                      17


<210> 18408
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18408
gccagucggu aaguuc                                                       16


<210> 18409
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18409
gccagucggu aaguu                                                        15


<210> 18410
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18410
gccagucggu aagu                                                         14


<210> 18411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18411
tcaaggaaga uggcauuucu                                                   20


<210> 18412
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18412
tcaaggaaga uggcauuucu ag                                                22


<210> 18413
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18413
tcaaggaaga uggcau                                                       16


<210> 18414
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18414
gaagauggca uuucu                                                        15


<210> 18415
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18415
tcaaggaaga uggcauuucu a                                                 21


<210> 18416
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18416
tcaaggaaga uggcauuuc                                                    19


<210> 18417
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18417
tcaaggaaga uggcauuu                                                     18


<210> 18418
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18418
tcaaggaaga uggcauu                                                      17


<210> 18419
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18419
tcaaggaaga uggca                                                        15


<210> 18420
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18420
tcaaggaaga uggc                                                         14


<210> 18421
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18421
tcaaggaaga ugg                                                          13


<210> 18422
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18422
tcaaggaaga ug                                                           12


<210> 18423
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18423
tcaaggaaga u                                                            11


<210> 18424
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18424
tcaaggaaga                                                              10


<210> 18425
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18425
tcaaggaag                                                                9


<210> 18426
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18426
caaggaagau ggcauuucua g                                                 21


<210> 18427
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18427
caaggaagau ggcauuucua                                                   20


<210> 18428
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18428
caaggaagau ggcauuucu                                                    19


<210> 18429
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18429
caaggaagau ggcauuuc                                                     18


<210> 18430
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18430
caaggaagau ggcauuu                                                      17


<210> 18431
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18431
caaggaagau ggcauu                                                       16


<210> 18432
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18432
caaggaagau ggcau                                                        15


<210> 18433
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18433
caaggaagau ggca                                                         14


<210> 18434
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18434
caaggaagau ggc                                                          13


<210> 18435
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18435
caaggaagau gg                                                           12


<210> 18436
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18436
caaggaagau g                                                            11


<210> 18437
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18437
caaggaagau                                                              10


<210> 18438
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18438
caaggaaga                                                                9


<210> 18439
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18439
caaggaag                                                                 8


<210> 18440
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18440
aaggaagaug gcauuucuag                                                   20


<210> 18441
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18441
aaggaagaug gcauuucua                                                    19


<210> 18442
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18442
aaggaagaug gcauuucu                                                     18


<210> 18443
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18443
aaggaagaug gcauuuc                                                      17


<210> 18444
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18444
aaggaagaug gcauuu                                                       16


<210> 18445
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18445
aaggaagaug gcauu                                                        15


<210> 18446
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18446
aaggaagaug gcau                                                         14


<210> 18447
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18447
aaggaagaug gca                                                          13


<210> 18448
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18448
aaggaagaug gc                                                           12


<210> 18449
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18449
aaggaagaug g                                                            11


<210> 18450
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18450
aaggaagaug                                                              10


<210> 18451
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18451
aaggaagau                                                                9


<210> 18452
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18452
aaggaaga                                                                 8


<210> 18453
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18453
aggaagaugg cauuucuag                                                    19


<210> 18454
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18454
aggaagaugg cauuucua                                                     18


<210> 18455
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18455
aggaagaugg cauuucu                                                      17


<210> 18456
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18456
aggaagaugg cauuuc                                                       16


<210> 18457
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18457
aggaagaugg cauuu                                                        15


<210> 18458
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18458
aggaagaugg cauu                                                         14


<210> 18459
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18459
aggaagaugg cau                                                          13


<210> 18460
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18460
aggaagaugg ca                                                           12


<210> 18461
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18461
aggaagaugg                                                              10


<210> 18462
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18462
aggaagaug                                                                9


<210> 18463
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18463
aggaagau                                                                 8


<210> 18464
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18464
ggaagauggc auuucuag                                                     18


<210> 18465
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18465
ggaagauggc auuucua                                                      17


<210> 18466
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18466
ggaagauggc auuucu                                                       16


<210> 18467
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18467
ggaagauggc auuuc                                                        15


<210> 18468
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18468
ggaagauggc auuu                                                         14


<210> 18469
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18469
ggaagauggc auu                                                          13


<210> 18470
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18470
ggaagauggc au                                                           12


<210> 18471
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18471
ggaagauggc a                                                            11


<210> 18472
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18472
ggaagauggc                                                              10


<210> 18473
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18473
ggaagaug                                                                 8


<210> 18474
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18474
gaagauggca uuucuag                                                      17


<210> 18475
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18475
gaagauggca uuucua                                                       16


<210> 18476
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18476
gaagauggca uuuc                                                         14


<210> 18477
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18477
gaagauggca uuu                                                          13


<210> 18478
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18478
gaagauggca uu                                                           12


<210> 18479
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18479
gaagauggca u                                                            11


<210> 18480
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18480
gaagauggca                                                              10


<210> 18481
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18481
gaagauggc                                                                9


<210> 18482
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18482
gaagaugg                                                                 8


<210> 18483
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18483
aagauggcau uucuag                                                       16


<210> 18484
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18484
aagauggcau uucua                                                        15


<210> 18485
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18485
aagauggcau uucu                                                         14


<210> 18486
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18486
aagauggcau uuc                                                          13


<210> 18487
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18487
aagauggcau uu                                                           12


<210> 18488
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18488
aagauggcau u                                                            11


<210> 18489
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18489
aagauggcau                                                              10


<210> 18490
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18490
aagauggca                                                                9


<210> 18491
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18491
aagauggc                                                                 8


<210> 18492
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18492
agauggcauu ucuag                                                        15


<210> 18493
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18493
agauggcauu ucua                                                         14


<210> 18494
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18494
agauggcauu ucu                                                          13


<210> 18495
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18495
agauggcauu uc                                                           12


<210> 18496
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18496
agauggcauu u                                                            11


<210> 18497
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18497
agauggcauu                                                              10


<210> 18498
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18498
agauggcau                                                                9


<210> 18499
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18499
agauggca                                                                 8


<210> 18500
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18500
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 18501
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18501
ctccaacauc aaggaagaug gcauuucua                                         29


<210> 18502
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18502
ctccaacauc aaggaagaug gcauuucu                                          28


<210> 18503
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18503
ctccaacauc aaggaagaug gcauuuc                                           27


<210> 18504
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18504
ctccaacauc aaggaagaug gcauuu                                            26


<210> 18505
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18505
ctccaacauc aaggaagaug gcauu                                             25


<210> 18506
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18506
ctccaacauc aaggaagaug gcau                                              24


<210> 18507
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18507
ctccaacauc aaggaagaug gca                                               23


<210> 18508
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18508
ctccaacauc aaggaagaug gc                                                22


<210> 18509
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18509
ctccaacauc aaggaagaug g                                                 21


<210> 18510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18510
ctccaacauc aaggaagaug                                                   20


<210> 18511
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18511
ctccaacauc aaggaagau                                                    19


<210> 18512
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18512
ctccaacauc aaggaaga                                                     18


<210> 18513
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18513
ctccaacauc aaggaag                                                      17


<210> 18514
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18514
tccaacauca aggaagaugg cauuucuag                                         29


<210> 18515
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18515
tccaacauca aggaagaugg cauuucua                                          28


<210> 18516
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18516
tccaacauca aggaagaugg cauuucu                                           27


<210> 18517
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18517
tccaacauca aggaagaugg cauuuc                                            26


<210> 18518
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18518
tccaacauca aggaagaugg cauuu                                             25


<210> 18519
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18519
tccaacauca aggaagaugg cauu                                              24


<210> 18520
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18520
tccaacauca aggaagaugg cau                                               23


<210> 18521
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18521
tccaacauca aggaagaugg ca                                                22


<210> 18522
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18522
tccaacauca aggaagaugg c                                                 21


<210> 18523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18523
tccaacauca aggaagaugg                                                   20


<210> 18524
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18524
tccaacauca aggaagaug                                                    19


<210> 18525
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18525
tccaacauca aggaagau                                                     18


<210> 18526
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18526
tccaacauca aggaaga                                                      17


<210> 18527
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18527
tccaacauca aggaag                                                       16


<210> 18528
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18528
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 18529
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18529
ccaacaucaa ggaagauggc auuucua                                           27


<210> 18530
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18530
ccaacaucaa ggaagauggc auuucu                                            26


<210> 18531
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18531
ccaacaucaa ggaagauggc auuuc                                             25


<210> 18532
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18532
ccaacaucaa ggaagauggc auuu                                              24


<210> 18533
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18533
ccaacaucaa ggaagauggc auu                                               23


<210> 18534
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18534
ccaacaucaa ggaagauggc au                                                22


<210> 18535
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18535
ccaacaucaa ggaagauggc a                                                 21


<210> 18536
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18536
ccaacaucaa ggaagauggc                                                   20


<210> 18537
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18537
ccaacaucaa ggaagaugg                                                    19


<210> 18538
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18538
ccaacaucaa ggaagaug                                                     18


<210> 18539
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18539
ccaacaucaa ggaagau                                                      17


<210> 18540
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18540
ccaacaucaa ggaaga                                                       16


<210> 18541
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18541
ccaacaucaa ggaag                                                        15


<210> 18542
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18542
caacaucaag gaagauggca uuucuag                                           27


<210> 18543
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18543
caacaucaag gaagauggca uuucua                                            26


<210> 18544
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18544
caacaucaag gaagauggca uuucu                                             25


<210> 18545
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18545
caacaucaag gaagauggca uuuc                                              24


<210> 18546
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18546
caacaucaag gaagauggca uuu                                               23


<210> 18547
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18547
caacaucaag gaagauggca uu                                                22


<210> 18548
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18548
caacaucaag gaagauggca u                                                 21


<210> 18549
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18549
caacaucaag gaagauggca                                                   20


<210> 18550
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18550
caacaucaag gaagauggc                                                    19


<210> 18551
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18551
caacaucaag gaagaugg                                                     18


<210> 18552
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18552
caacaucaag gaagaug                                                      17


<210> 18553
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18553
caacaucaag gaagau                                                       16


<210> 18554
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18554
caacaucaag gaaga                                                        15


<210> 18555
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18555
caacaucaag gaag                                                         14


<210> 18556
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18556
aacaucaagg aagauggcau uucuag                                            26


<210> 18557
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18557
aacaucaagg aagauggcau uucua                                             25


<210> 18558
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18558
aacaucaagg aagauggcau uucu                                              24


<210> 18559
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18559
aacaucaagg aagauggcau uuc                                               23


<210> 18560
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18560
aacaucaagg aagauggcau uu                                                22


<210> 18561
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18561
aacaucaagg aagauggcau u                                                 21


<210> 18562
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18562
aacaucaagg aagauggcau                                                   20


<210> 18563
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18563
aacaucaagg aagauggca                                                    19


<210> 18564
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18564
aacaucaagg aagauggc                                                     18


<210> 18565
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18565
aacaucaagg aagaugg                                                      17


<210> 18566
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18566
aacaucaagg aagaug                                                       16


<210> 18567
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18567
aacaucaagg aagau                                                        15


<210> 18568
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18568
aacaucaagg aaga                                                         14


<210> 18569
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18569
aacaucaagg aag                                                          13


<210> 18570
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18570
acaucaagga agauggcauu ucuag                                             25


<210> 18571
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18571
acaucaagga agauggcauu ucua                                              24


<210> 18572
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18572
acaucaagga agauggcauu ucu                                               23


<210> 18573
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18573
acaucaagga agauggcauu uc                                                22


<210> 18574
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18574
acaucaagga agauggcauu u                                                 21


<210> 18575
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18575
acaucaagga agauggcauu                                                   20


<210> 18576
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18576
acaucaagga agauggcau                                                    19


<210> 18577
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18577
acaucaagga agauggca                                                     18


<210> 18578
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18578
acaucaagga agauggc                                                      17


<210> 18579
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18579
acaucaagga agaugg                                                       16


<210> 18580
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18580
acaucaagga agaug                                                        15


<210> 18581
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18581
acaucaagga agau                                                         14


<210> 18582
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18582
acaucaagga aga                                                          13


<210> 18583
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18583
acaucaagga ag                                                           12


<210> 18584
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18584
caucaaggaa gauggcauuu cuag                                              24


<210> 18585
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18585
caucaaggaa gauggcauuu cua                                               23


<210> 18586
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18586
caucaaggaa gauggcauuu cu                                                22


<210> 18587
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18587
caucaaggaa gauggcauuu c                                                 21


<210> 18588
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18588
caucaaggaa gauggcauuu                                                   20


<210> 18589
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18589
caucaaggaa gauggcauu                                                    19


<210> 18590
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18590
caucaaggaa gauggcau                                                     18


<210> 18591
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18591
caucaaggaa gauggca                                                      17


<210> 18592
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18592
caucaaggaa gauggc                                                       16


<210> 18593
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18593
caucaaggaa gaugg                                                        15


<210> 18594
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18594
caucaaggaa gaug                                                         14


<210> 18595
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18595
caucaaggaa gau                                                          13


<210> 18596
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18596
caucaaggaa ga                                                           12


<210> 18597
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18597
caucaaggaa g                                                            11


<210> 18598
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18598
atcaaggaag auggcauuuc uag                                               23


<210> 18599
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18599
atcaaggaag auggcauuuc ua                                                22


<210> 18600
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18600
atcaaggaag auggcauuuc u                                                 21


<210> 18601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18601
atcaaggaag auggcauuuc                                                   20


<210> 18602
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18602
atcaaggaag auggcauuu                                                    19


<210> 18603
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18603
atcaaggaag auggcauu                                                     18


<210> 18604
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18604
atcaaggaag auggcau                                                      17


<210> 18605
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18605
atcaaggaag auggca                                                       16


<210> 18606
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18606
atcaaggaag auggc                                                        15


<210> 18607
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18607
atcaaggaag augg                                                         14


<210> 18608
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18608
atcaaggaag aug                                                          13


<210> 18609
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18609
atcaaggaag au                                                           12


<210> 18610
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18610
atcaaggaag a                                                            11


<210> 18611
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18611
atcaaggaag                                                              10


<210> 18612
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18612
ccagagcagg uaccuccaac auc                                               23


<210> 18613
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18613
ccagagcagg uaccucca                                                     18


<210> 18614
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18614
ccucugugau uuuauaacuu gau                                               23


<210> 18615
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18615
tcacccacca ucacccu                                                      17


<210> 18616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18616
tgauauccuc aaggucaccc                                                   20


<210> 18617
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18617
ctgcuugaug aucaucucgu ug                                                22


<210> 18618
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18618
ctgcuugaug aucaucuc                                                     18


<210> 18619
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18619
gtuuccuuag uaaccacag                                                    19


<210> 18620
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18620
gtuuccuuag uaaccac                                                      17


<210> 18621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18621
tcaaggaaga uggcauuucu                                                   20


<210> 18622
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18622
tcaaggaaga uggcauuucu ag                                                22


<210> 18623
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18623
gguaaguucu guccaagc                                                     18


<210> 18624
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18624
gtaaguucug uccaagcc                                                     18


<210> 18625
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18625
agucgguaag uucugucc                                                     18


<210> 18626
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18626
ctguccaagc ccgguuga                                                     18


<210> 18627
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18627
taaguucugu ccaag                                                        15


<210> 18628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18628
ttcuguccaa gcccgguuga                                                   20


<210> 18629
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18629
ttcuguccaa gcccgguug                                                    19


<210> 18630
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18630
ttcuguccaa gcccgguu                                                     18


<210> 18631
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18631
ttcuguccaa gcccggu                                                      17


<210> 18632
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18632
ttcuguccaa gcccgg                                                       16


<210> 18633
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18633
ttcuguccaa gcccg                                                        15


<210> 18634
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18634
ttcuguccaa gccc                                                         14


<210> 18635
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18635
ttcuguccaa gcc                                                          13


<210> 18636
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18636
ttcuguccaa gc                                                           12


<210> 18637
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18637
ttcuguccaa g                                                            11


<210> 18638
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18638
ttcuguccaa                                                              10


<210> 18639
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18639
ttcugucca                                                                9


<210> 18640
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18640
ttcugucc                                                                 8


<210> 18641
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18641
tcuguccaag cccgguuga                                                    19


<210> 18642
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18642
tcuguccaag cccgguug                                                     18


<210> 18643
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18643
tcuguccaag cccgguu                                                      17


<210> 18644
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18644
tcuguccaag cccggu                                                       16


<210> 18645
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18645
tcuguccaag cccgg                                                        15


<210> 18646
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18646
tcuguccaag cccg                                                         14


<210> 18647
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18647
tcuguccaag ccc                                                          13


<210> 18648
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18648
tcuguccaag cc                                                           12


<210> 18649
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18649
tcuguccaag c                                                            11


<210> 18650
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18650
tcuguccaag                                                              10


<210> 18651
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18651
tcuguccaa                                                                9


<210> 18652
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18652
tcugucca                                                                 8


<210> 18653
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18653
ctguccaagc ccgguug                                                      17


<210> 18654
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18654
ctguccaagc ccgguu                                                       16


<210> 18655
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18655
ctguccaagc ccggu                                                        15


<210> 18656
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18656
ctguccaagc ccgg                                                         14


<210> 18657
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18657
ctguccaagc ccg                                                          13


<210> 18658
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18658
ctguccaagc cc                                                           12


<210> 18659
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18659
ctguccaagc c                                                            11


<210> 18660
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18660
ctguccaagc                                                              10


<210> 18661
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18661
ctguccaag                                                                9


<210> 18662
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18662
ctguccaa                                                                 8


<210> 18663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18663
gtucugucca agcccgguug                                                   20


<210> 18664
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18664
gtucugucca agcccgguu                                                    19


<210> 18665
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18665
gtucugucca agcccggu                                                     18


<210> 18666
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18666
gtucugucca agcccgg                                                      17


<210> 18667
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18667
gtucugucca agcccg                                                       16


<210> 18668
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18668
gtucugucca agccc                                                        15


<210> 18669
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18669
gtucugucca agcc                                                         14


<210> 18670
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18670
gtucugucca agc                                                          13


<210> 18671
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18671
gtucugucca ag                                                           12


<210> 18672
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18672
gtucugucca a                                                            11


<210> 18673
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18673
gtucugucca                                                              10


<210> 18674
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18674
gtucugucc                                                                9


<210> 18675
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18675
gtucuguc                                                                 8


<210> 18676
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18676
aguucugucc aagcccgguu                                                   20


<210> 18677
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18677
aguucugucc aagcccggu                                                    19


<210> 18678
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18678
aguucugucc aagcccgg                                                     18


<210> 18679
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18679
aguucugucc aagcccg                                                      17


<210> 18680
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18680
aguucugucc aagccc                                                       16


<210> 18681
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18681
aguucugucc aagcc                                                        15


<210> 18682
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18682
aguucugucc aagc                                                         14


<210> 18683
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18683
aguucugucc aag                                                          13


<210> 18684
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18684
aguucugucc aa                                                           12


<210> 18685
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18685
aguucugucc a                                                            11


<210> 18686
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18686
aguucugucc                                                              10


<210> 18687
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18687
aguucuguc                                                                9


<210> 18688
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18688
aguucugu                                                                 8


<210> 18689
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18689
aaguucuguc caagcccggu                                                   20


<210> 18690
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18690
aaguucuguc caagcccgg                                                    19


<210> 18691
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18691
aaguucuguc caagcccg                                                     18


<210> 18692
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18692
aaguucuguc caagccc                                                      17


<210> 18693
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18693
aaguucuguc caagcc                                                       16


<210> 18694
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18694
aaguucuguc caagc                                                        15


<210> 18695
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18695
aaguucuguc caag                                                         14


<210> 18696
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18696
aaguucuguc caa                                                          13


<210> 18697
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18697
aaguucuguc ca                                                           12


<210> 18698
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18698
aaguucuguc c                                                            11


<210> 18699
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18699
aaguucuguc                                                              10


<210> 18700
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18700
aaguucugu                                                                9


<210> 18701
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18701
aaguucug                                                                 8


<210> 18702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18702
taaguucugu ccaagcccgg                                                   20


<210> 18703
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18703
taaguucugu ccaagcccg                                                    19


<210> 18704
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18704
taaguucugu ccaagccc                                                     18


<210> 18705
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18705
taaguucugu ccaagcc                                                      17


<210> 18706
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18706
taaguucugu ccaagc                                                       16


<210> 18707
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18707
taaguucugu ccaa                                                         14


<210> 18708
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18708
taaguucugu cca                                                          13


<210> 18709
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18709
taaguucugu cc                                                           12


<210> 18710
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18710
taaguucugu c                                                            11


<210> 18711
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18711
taaguucugu                                                              10


<210> 18712
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18712
taaguucug                                                                9


<210> 18713
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18713
taaguucu                                                                 8


<210> 18714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18714
gtaaguucug uccaagcccg                                                   20


<210> 18715
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18715
gtaaguucug uccaagccc                                                    19


<210> 18716
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18716
gtaaguucug uccaagc                                                      17


<210> 18717
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18717
gtaaguucug uccaag                                                       16


<210> 18718
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18718
gtaaguucug uccaa                                                        15


<210> 18719
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18719
gtaaguucug ucca                                                         14


<210> 18720
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18720
gtaaguucug ucc                                                          13


<210> 18721
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18721
gtaaguucug uc                                                           12


<210> 18722
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18722
gtaaguucug u                                                            11


<210> 18723
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18723
gtaaguucug                                                              10


<210> 18724
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18724
gtaaguucu                                                                9


<210> 18725
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18725
gtaaguuc                                                                 8


<210> 18726
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18726
gguaaguucu guccaagccc                                                   20


<210> 18727
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18727
gguaaguucu guccaagcc                                                    19


<210> 18728
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18728
gguaaguucu guccaag                                                      17


<210> 18729
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18729
gguaaguucu guccaa                                                       16


<210> 18730
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18730
gguaaguucu gucca                                                        15


<210> 18731
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18731
gguaaguucu gucc                                                         14


<210> 18732
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18732
gguaaguucu guc                                                          13


<210> 18733
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18733
gguaaguucu gu                                                           12


<210> 18734
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18734
gguaaguucu g                                                            11


<210> 18735
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18735
gguaaguucu                                                              10


<210> 18736
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18736
gguaaguuc                                                                9


<210> 18737
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18737
gguaaguu                                                                 8


<210> 18738
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18738
cgguaaguuc uguccaagcc                                                   20


<210> 18739
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18739
cgguaaguuc uguccaagc                                                    19


<210> 18740
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18740
cgguaaguuc uguccaag                                                     18


<210> 18741
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18741
cgguaaguuc uguccaa                                                      17


<210> 18742
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18742
cgguaaguuc ugucca                                                       16


<210> 18743
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18743
cgguaaguuc ugucc                                                        15


<210> 18744
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18744
cgguaaguuc uguc                                                         14


<210> 18745
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18745
cgguaaguuc ugu                                                          13


<210> 18746
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18746
cgguaaguuc ug                                                           12


<210> 18747
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18747
cgguaaguuc u                                                            11


<210> 18748
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18748
cgguaaguuc                                                              10


<210> 18749
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18749
cgguaaguu                                                                9


<210> 18750
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18750
cgguaagu                                                                 8


<210> 18751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18751
tcgguaaguu cuguccaagc                                                   20


<210> 18752
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18752
tcgguaaguu cuguccaag                                                    19


<210> 18753
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18753
tcgguaaguu cuguccaa                                                     18


<210> 18754
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18754
tcgguaaguu cugucca                                                      17


<210> 18755
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18755
tcgguaaguu cugucc                                                       16


<210> 18756
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18756
tcgguaaguu cuguc                                                        15


<210> 18757
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18757
tcgguaaguu cugu                                                         14


<210> 18758
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18758
tcgguaaguu cug                                                          13


<210> 18759
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18759
tcgguaaguu cu                                                           12


<210> 18760
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18760
tcgguaaguu c                                                            11


<210> 18761
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18761
tcgguaaguu                                                              10


<210> 18762
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18762
tcgguaagu                                                                9


<210> 18763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18763
gtcgguaagu ucuguccaag                                                   20


<210> 18764
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18764
gtcgguaagu ucuguccaa                                                    19


<210> 18765
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18765
gtcgguaagu ucugucca                                                     18


<210> 18766
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18766
gtcgguaagu ucugucc                                                      17


<210> 18767
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18767
gtcgguaagu ucuguc                                                       16


<210> 18768
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18768
gtcgguaagu ucugu                                                        15


<210> 18769
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18769
gtcgguaagu ucug                                                         14


<210> 18770
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18770
gtcgguaagu ucu                                                          13


<210> 18771
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18771
gtcgguaagu uc                                                           12


<210> 18772
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18772
gtcgguaagu u                                                            11


<210> 18773
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18773
gtcgguaagu                                                              10


<210> 18774
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18774
agucgguaag uucuguccaa                                                   20


<210> 18775
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18775
agucgguaag uucugucca                                                    19


<210> 18776
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18776
agucgguaag uucuguc                                                      17


<210> 18777
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18777
agucgguaag uucugu                                                       16


<210> 18778
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18778
agucgguaag uucug                                                        15


<210> 18779
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18779
agucgguaag uucu                                                         14


<210> 18780
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18780
agucgguaag uuc                                                          13


<210> 18781
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18781
agucgguaag uu                                                           12


<210> 18782
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18782
agucgguaag u                                                            11


<210> 18783
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18783
cagucgguaa guucugucca                                                   20


<210> 18784
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18784
cagucgguaa guucugucc                                                    19


<210> 18785
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18785
cagucgguaa guucuguc                                                     18


<210> 18786
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18786
cagucgguaa guucugu                                                      17


<210> 18787
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18787
cagucgguaa guucug                                                       16


<210> 18788
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18788
cagucgguaa guucu                                                        15


<210> 18789
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18789
cagucgguaa guuc                                                         14


<210> 18790
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18790
cagucgguaa guu                                                          13


<210> 18791
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18791
cagucgguaa gu                                                           12


<210> 18792
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18792
ccagucggua aguucugucc                                                   20


<210> 18793
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18793
ccagucggua aguucuguc                                                    19


<210> 18794
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18794
ccagucggua aguucugu                                                     18


<210> 18795
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18795
ccagucggua aguucug                                                      17


<210> 18796
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18796
ccagucggua aguucu                                                       16


<210> 18797
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18797
ccagucggua aguuc                                                        15


<210> 18798
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18798
ccagucggua aguu                                                         14


<210> 18799
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18799
ccagucggua agu                                                          13


<210> 18800
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18800
gccagucggu aaguucuguc                                                   20


<210> 18801
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18801
gccagucggu aaguucugu                                                    19


<210> 18802
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18802
gccagucggu aaguucug                                                     18


<210> 18803
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18803
gccagucggu aaguucu                                                      17


<210> 18804
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18804
gccagucggu aaguuc                                                       16


<210> 18805
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18805
gccagucggu aaguu                                                        15


<210> 18806
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18806
gccagucggu aagu                                                         14


<210> 18807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18807
tcaaggaaga uggcauuucu                                                   20


<210> 18808
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18808
tcaaggaaga uggcauuucu ag                                                22


<210> 18809
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18809
tcaaggaaga uggcau                                                       16


<210> 18810
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18810
gaagauggca uuucu                                                        15


<210> 18811
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18811
tcaaggaaga uggcauuucu a                                                 21


<210> 18812
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18812
tcaaggaaga uggcauuuc                                                    19


<210> 18813
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18813
tcaaggaaga uggcauuu                                                     18


<210> 18814
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18814
tcaaggaaga uggcauu                                                      17


<210> 18815
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18815
tcaaggaaga uggca                                                        15


<210> 18816
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18816
tcaaggaaga uggc                                                         14


<210> 18817
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18817
tcaaggaaga ugg                                                          13


<210> 18818
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18818
tcaaggaaga ug                                                           12


<210> 18819
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18819
tcaaggaaga u                                                            11


<210> 18820
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18820
tcaaggaaga                                                              10


<210> 18821
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18821
tcaaggaag                                                                9


<210> 18822
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18822
caaggaagau ggcauuucua g                                                 21


<210> 18823
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18823
caaggaagau ggcauuucua                                                   20


<210> 18824
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18824
caaggaagau ggcauuucu                                                    19


<210> 18825
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18825
caaggaagau ggcauuuc                                                     18


<210> 18826
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18826
caaggaagau ggcauuu                                                      17


<210> 18827
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18827
caaggaagau ggcauu                                                       16


<210> 18828
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18828
caaggaagau ggcau                                                        15


<210> 18829
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18829
caaggaagau ggca                                                         14


<210> 18830
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18830
caaggaagau ggc                                                          13


<210> 18831
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18831
caaggaagau gg                                                           12


<210> 18832
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18832
caaggaagau g                                                            11


<210> 18833
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18833
caaggaagau                                                              10


<210> 18834
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18834
caaggaaga                                                                9


<210> 18835
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18835
caaggaag                                                                 8


<210> 18836
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18836
aaggaagaug gcauuucuag                                                   20


<210> 18837
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18837
aaggaagaug gcauuucua                                                    19


<210> 18838
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18838
aaggaagaug gcauuucu                                                     18


<210> 18839
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18839
aaggaagaug gcauuuc                                                      17


<210> 18840
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18840
aaggaagaug gcauuu                                                       16


<210> 18841
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18841
aaggaagaug gcauu                                                        15


<210> 18842
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18842
aaggaagaug gcau                                                         14


<210> 18843
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18843
aaggaagaug gca                                                          13


<210> 18844
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18844
aaggaagaug gc                                                           12


<210> 18845
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18845
aaggaagaug g                                                            11


<210> 18846
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18846
aaggaagaug                                                              10


<210> 18847
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18847
aaggaagau                                                                9


<210> 18848
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18848
aaggaaga                                                                 8


<210> 18849
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18849
aggaagaugg cauuucuag                                                    19


<210> 18850
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18850
aggaagaugg cauuucua                                                     18


<210> 18851
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18851
aggaagaugg cauuucu                                                      17


<210> 18852
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18852
aggaagaugg cauuuc                                                       16


<210> 18853
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18853
aggaagaugg cauuu                                                        15


<210> 18854
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18854
aggaagaugg cauu                                                         14


<210> 18855
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18855
aggaagaugg cau                                                          13


<210> 18856
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18856
aggaagaugg ca                                                           12


<210> 18857
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18857
aggaagaugg                                                              10


<210> 18858
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18858
aggaagaug                                                                9


<210> 18859
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18859
aggaagau                                                                 8


<210> 18860
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18860
ggaagauggc auuucuag                                                     18


<210> 18861
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18861
ggaagauggc auuucua                                                      17


<210> 18862
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18862
ggaagauggc auuucu                                                       16


<210> 18863
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18863
ggaagauggc auuuc                                                        15


<210> 18864
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18864
ggaagauggc auuu                                                         14


<210> 18865
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18865
ggaagauggc auu                                                          13


<210> 18866
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18866
ggaagauggc au                                                           12


<210> 18867
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18867
ggaagauggc a                                                            11


<210> 18868
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18868
ggaagauggc                                                              10


<210> 18869
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18869
ggaagaug                                                                 8


<210> 18870
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18870
gaagauggca uuucuag                                                      17


<210> 18871
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18871
gaagauggca uuucua                                                       16


<210> 18872
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18872
gaagauggca uuuc                                                         14


<210> 18873
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18873
gaagauggca uuu                                                          13


<210> 18874
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18874
gaagauggca uu                                                           12


<210> 18875
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18875
gaagauggca u                                                            11


<210> 18876
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18876
gaagauggca                                                              10


<210> 18877
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18877
gaagauggc                                                                9


<210> 18878
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18878
gaagaugg                                                                 8


<210> 18879
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18879
aagauggcau uucuag                                                       16


<210> 18880
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18880
aagauggcau uucua                                                        15


<210> 18881
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18881
aagauggcau uucu                                                         14


<210> 18882
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18882
aagauggcau uuc                                                          13


<210> 18883
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18883
aagauggcau uu                                                           12


<210> 18884
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18884
aagauggcau u                                                            11


<210> 18885
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18885
aagauggcau                                                              10


<210> 18886
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18886
aagauggca                                                                9


<210> 18887
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18887
aagauggc                                                                 8


<210> 18888
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18888
agauggcauu ucuag                                                        15


<210> 18889
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18889
agauggcauu ucua                                                         14


<210> 18890
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18890
agauggcauu ucu                                                          13


<210> 18891
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18891
agauggcauu uc                                                           12


<210> 18892
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18892
agauggcauu u                                                            11


<210> 18893
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18893
agauggcauu                                                              10


<210> 18894
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18894
agauggcau                                                                9


<210> 18895
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18895
agauggca                                                                 8


<210> 18896
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18896
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 18897
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18897
ctccaacauc aaggaagaug gcauuucua                                         29


<210> 18898
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18898
ctccaacauc aaggaagaug gcauuucu                                          28


<210> 18899
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18899
ctccaacauc aaggaagaug gcauuuc                                           27


<210> 18900
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18900
ctccaacauc aaggaagaug gcauuu                                            26


<210> 18901
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18901
ctccaacauc aaggaagaug gcauu                                             25


<210> 18902
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18902
ctccaacauc aaggaagaug gcau                                              24


<210> 18903
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18903
ctccaacauc aaggaagaug gca                                               23


<210> 18904
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18904
ctccaacauc aaggaagaug gc                                                22


<210> 18905
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18905
ctccaacauc aaggaagaug g                                                 21


<210> 18906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18906
ctccaacauc aaggaagaug                                                   20


<210> 18907
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18907
ctccaacauc aaggaagau                                                    19


<210> 18908
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18908
ctccaacauc aaggaaga                                                     18


<210> 18909
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18909
ctccaacauc aaggaag                                                      17


<210> 18910
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18910
tccaacauca aggaagaugg cauuucuag                                         29


<210> 18911
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18911
tccaacauca aggaagaugg cauuucua                                          28


<210> 18912
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18912
tccaacauca aggaagaugg cauuucu                                           27


<210> 18913
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18913
tccaacauca aggaagaugg cauuuc                                            26


<210> 18914
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18914
tccaacauca aggaagaugg cauuu                                             25


<210> 18915
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18915
tccaacauca aggaagaugg cauu                                              24


<210> 18916
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18916
tccaacauca aggaagaugg cau                                               23


<210> 18917
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18917
tccaacauca aggaagaugg ca                                                22


<210> 18918
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18918
tccaacauca aggaagaugg c                                                 21


<210> 18919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18919
tccaacauca aggaagaugg                                                   20


<210> 18920
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18920
tccaacauca aggaagaug                                                    19


<210> 18921
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18921
tccaacauca aggaagau                                                     18


<210> 18922
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18922
tccaacauca aggaaga                                                      17


<210> 18923
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18923
tccaacauca aggaag                                                       16


<210> 18924
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18924
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 18925
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18925
ccaacaucaa ggaagauggc auuucua                                           27


<210> 18926
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18926
ccaacaucaa ggaagauggc auuucu                                            26


<210> 18927
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18927
ccaacaucaa ggaagauggc auuuc                                             25


<210> 18928
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18928
ccaacaucaa ggaagauggc auuu                                              24


<210> 18929
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18929
ccaacaucaa ggaagauggc auu                                               23


<210> 18930
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18930
ccaacaucaa ggaagauggc au                                                22


<210> 18931
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18931
ccaacaucaa ggaagauggc a                                                 21


<210> 18932
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18932
ccaacaucaa ggaagauggc                                                   20


<210> 18933
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18933
ccaacaucaa ggaagaugg                                                    19


<210> 18934
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18934
ccaacaucaa ggaagaug                                                     18


<210> 18935
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18935
ccaacaucaa ggaagau                                                      17


<210> 18936
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18936
ccaacaucaa ggaaga                                                       16


<210> 18937
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18937
ccaacaucaa ggaag                                                        15


<210> 18938
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18938
caacaucaag gaagauggca uuucuag                                           27


<210> 18939
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18939
caacaucaag gaagauggca uuucua                                            26


<210> 18940
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18940
caacaucaag gaagauggca uuucu                                             25


<210> 18941
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18941
caacaucaag gaagauggca uuuc                                              24


<210> 18942
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18942
caacaucaag gaagauggca uuu                                               23


<210> 18943
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18943
caacaucaag gaagauggca uu                                                22


<210> 18944
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18944
caacaucaag gaagauggca u                                                 21


<210> 18945
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18945
caacaucaag gaagauggca                                                   20


<210> 18946
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18946
caacaucaag gaagauggc                                                    19


<210> 18947
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18947
caacaucaag gaagaugg                                                     18


<210> 18948
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18948
caacaucaag gaagaug                                                      17


<210> 18949
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18949
caacaucaag gaagau                                                       16


<210> 18950
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18950
caacaucaag gaaga                                                        15


<210> 18951
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18951
caacaucaag gaag                                                         14


<210> 18952
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18952
aacaucaagg aagauggcau uucuag                                            26


<210> 18953
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18953
aacaucaagg aagauggcau uucua                                             25


<210> 18954
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18954
aacaucaagg aagauggcau uucu                                              24


<210> 18955
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18955
aacaucaagg aagauggcau uuc                                               23


<210> 18956
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18956
aacaucaagg aagauggcau uu                                                22


<210> 18957
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18957
aacaucaagg aagauggcau u                                                 21


<210> 18958
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18958
aacaucaagg aagauggcau                                                   20


<210> 18959
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18959
aacaucaagg aagauggca                                                    19


<210> 18960
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18960
aacaucaagg aagauggc                                                     18


<210> 18961
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18961
aacaucaagg aagaugg                                                      17


<210> 18962
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18962
aacaucaagg aagaug                                                       16


<210> 18963
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18963
aacaucaagg aagau                                                        15


<210> 18964
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18964
aacaucaagg aaga                                                         14


<210> 18965
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18965
aacaucaagg aag                                                          13


<210> 18966
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18966
acaucaagga agauggcauu ucuag                                             25


<210> 18967
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18967
acaucaagga agauggcauu ucua                                              24


<210> 18968
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18968
acaucaagga agauggcauu ucu                                               23


<210> 18969
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18969
acaucaagga agauggcauu uc                                                22


<210> 18970
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18970
acaucaagga agauggcauu u                                                 21


<210> 18971
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18971
acaucaagga agauggcauu                                                   20


<210> 18972
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18972
acaucaagga agauggcau                                                    19


<210> 18973
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18973
acaucaagga agauggca                                                     18


<210> 18974
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18974
acaucaagga agauggc                                                      17


<210> 18975
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18975
acaucaagga agaugg                                                       16


<210> 18976
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18976
acaucaagga agaug                                                        15


<210> 18977
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18977
acaucaagga agau                                                         14


<210> 18978
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18978
acaucaagga aga                                                          13


<210> 18979
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18979
acaucaagga ag                                                           12


<210> 18980
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18980
caucaaggaa gauggcauuu cuag                                              24


<210> 18981
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18981
caucaaggaa gauggcauuu cua                                               23


<210> 18982
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18982
caucaaggaa gauggcauuu cu                                                22


<210> 18983
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18983
caucaaggaa gauggcauuu c                                                 21


<210> 18984
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18984
caucaaggaa gauggcauuu                                                   20


<210> 18985
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18985
caucaaggaa gauggcauu                                                    19


<210> 18986
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18986
caucaaggaa gauggcau                                                     18


<210> 18987
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18987
caucaaggaa gauggca                                                      17


<210> 18988
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18988
caucaaggaa gauggc                                                       16


<210> 18989
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18989
caucaaggaa gaugg                                                        15


<210> 18990
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18990
caucaaggaa gaug                                                         14


<210> 18991
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18991
caucaaggaa gau                                                          13


<210> 18992
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18992
caucaaggaa ga                                                           12


<210> 18993
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18993
caucaaggaa g                                                            11


<210> 18994
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18994
atcaaggaag auggcauuuc uag                                               23


<210> 18995
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18995
atcaaggaag auggcauuuc ua                                                22


<210> 18996
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18996
atcaaggaag auggcauuuc u                                                 21


<210> 18997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18997
atcaaggaag auggcauuuc                                                   20


<210> 18998
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18998
atcaaggaag auggcauuu                                                    19


<210> 18999
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 18999
atcaaggaag auggcauu                                                     18


<210> 19000
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19000
atcaaggaag auggcau                                                      17


<210> 19001
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19001
atcaaggaag auggca                                                       16


<210> 19002
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19002
atcaaggaag auggc                                                        15


<210> 19003
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19003
atcaaggaag augg                                                         14


<210> 19004
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19004
atcaaggaag aug                                                          13


<210> 19005
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19005
atcaaggaag au                                                           12


<210> 19006
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19006
atcaaggaag a                                                            11


<210> 19007
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19007
atcaaggaag                                                              10


<210> 19008
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19008
ccagagcagg uaccuccaac auc                                               23


<210> 19009
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19009
ccagagcagg uaccucca                                                     18


<210> 19010
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19010
ccucugugau uuuauaacuu gau                                               23


<210> 19011
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19011
tcacccacca ucacccu                                                      17


<210> 19012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19012
tgauauccuc aaggucaccc                                                   20


<210> 19013
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19013
ctgcuugaug aucaucucgu ug                                                22


<210> 19014
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19014
ctgcuugaug aucaucuc                                                     18


<210> 19015
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19015
gtuuccuuag uaaccacag                                                    19


<210> 19016
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19016
gtuuccuuag uaaccac                                                      17


<210> 19017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19017
ucaaggaaga uggcauuuct                                                   20


<210> 19018
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19018
ucaaggaaga uggcauuucu ag                                                22


<210> 19019
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19019
gguaaguucu guccaagc                                                     18


<210> 19020
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19020
guaaguucug uccaagcc                                                     18


<210> 19021
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19021
agucgguaag uucugucc                                                     18


<210> 19022
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19022
cuguccaagc ccgguuga                                                     18


<210> 19023
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19023
uaaguucugu ccaag                                                        15


<210> 19024
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19024
uucuguccaa gcccgguuga                                                   20


<210> 19025
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19025
uucuguccaa gcccggutg                                                    19


<210> 19026
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19026
uucuguccaa gcccggtt                                                     18


<210> 19027
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19027
uucuguccaa gcccggt                                                      17


<210> 19028
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19028
uucuguccaa gcccgg                                                       16


<210> 19029
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19029
uucuguccaa gcccg                                                        15


<210> 19030
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19030
uucuguccaa gccc                                                         14


<210> 19031
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19031
uucuguccaa gcc                                                          13


<210> 19032
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19032
uucuguccaa gc                                                           12


<210> 19033
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19033
uucuguccaa g                                                            11


<210> 19034
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19034
uucuguccaa                                                              10


<210> 19035
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19035
uucugucca                                                                9


<210> 19036
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 19036
uucugucc                                                                 8


<210> 19037
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19037
ucuguccaag cccgguuga                                                    19


<210> 19038
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19038
ucuguccaag cccggutg                                                     18


<210> 19039
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19039
ucuguccaag cccggtt                                                      17


<210> 19040
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19040
ucuguccaag cccggt                                                       16


<210> 19041
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19041
ucuguccaag cccgg                                                        15


<210> 19042
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19042
ucuguccaag cccg                                                         14


<210> 19043
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19043
ucuguccaag ccc                                                          13


<210> 19044
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19044
ucuguccaag cc                                                           12


<210> 19045
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 19045
ucuguccaag c                                                            11


<210> 19046
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19046
ucuguccaag                                                              10


<210> 19047
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19047
ucuguccaa                                                                9


<210> 19048
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19048
ucugucca                                                                 8


<210> 19049
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19049
cuguccaagc ccggutg                                                      17


<210> 19050
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19050
cuguccaagc ccggtt                                                       16


<210> 19051
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19051
cuguccaagc ccggt                                                        15


<210> 19052
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19052
cuguccaagc ccgg                                                         14


<210> 19053
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19053
cuguccaagc ccg                                                          13


<210> 19054
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19054
cuguccaagc cc                                                           12


<210> 19055
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 19055
cuguccaagc c                                                            11


<210> 19056
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 19056
cuguccaagc                                                              10


<210> 19057
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19057
cuguccaag                                                                9


<210> 19058
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19058
cuguccaa                                                                 8


<210> 19059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19059
guucugucca agcccggutg                                                   20


<210> 19060
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19060
guucugucca agcccggtt                                                    19


<210> 19061
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19061
guucugucca agcccggt                                                     18


<210> 19062
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19062
guucugucca agcccgg                                                      17


<210> 19063
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19063
guucugucca agcccg                                                       16


<210> 19064
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19064
guucugucca agccc                                                        15


<210> 19065
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19065
guucugucca agcc                                                         14


<210> 19066
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19066
guucugucca agc                                                          13


<210> 19067
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19067
guucugucca ag                                                           12


<210> 19068
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19068
guucugucca a                                                            11


<210> 19069
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19069
guucugucca                                                              10


<210> 19070
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 19070
guucugucc                                                                9


<210> 19071
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 19071
guucugtc                                                                 8


<210> 19072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19072
aguucugucc aagcccggtt                                                   20


<210> 19073
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19073
aguucugucc aagcccggt                                                    19


<210> 19074
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19074
aguucugucc aagcccgg                                                     18


<210> 19075
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19075
aguucugucc aagcccg                                                      17


<210> 19076
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19076
aguucugucc aagccc                                                       16


<210> 19077
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19077
aguucugucc aagcc                                                        15


<210> 19078
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19078
aguucugucc aagc                                                         14


<210> 19079
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19079
aguucugucc aag                                                          13


<210> 19080
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19080
aguucugucc aa                                                           12


<210> 19081
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19081
aguucugucc a                                                            11


<210> 19082
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 19082
aguucugucc                                                              10


<210> 19083
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 19083
aguucugtc                                                                9


<210> 19084
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19084
aguucugt                                                                 8


<210> 19085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19085
aaguucuguc caagcccggt                                                   20


<210> 19086
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19086
aaguucuguc caagcccgg                                                    19


<210> 19087
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19087
aaguucuguc caagcccg                                                     18


<210> 19088
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19088
aaguucuguc caagccc                                                      17


<210> 19089
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19089
aaguucuguc caagcc                                                       16


<210> 19090
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19090
aaguucuguc caagc                                                        15


<210> 19091
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19091
aaguucuguc caag                                                         14


<210> 19092
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19092
aaguucuguc caa                                                          13


<210> 19093
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19093
aaguucuguc ca                                                           12


<210> 19094
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 19094
aaguucuguc c                                                            11


<210> 19095
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 19095
aaguucugtc                                                              10


<210> 19096
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19096
aaguucugt                                                                9


<210> 19097
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19097
aaguuctg                                                                 8


<210> 19098
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19098
uaaguucugu ccaagcccgg                                                   20


<210> 19099
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19099
uaaguucugu ccaagcccg                                                    19


<210> 19100
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19100
uaaguucugu ccaagccc                                                     18


<210> 19101
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19101
uaaguucugu ccaagcc                                                      17


<210> 19102
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19102
uaaguucugu ccaagc                                                       16


<210> 19103
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19103
uaaguucugu ccaa                                                         14


<210> 19104
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19104
uaaguucugu cca                                                          13


<210> 19105
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19105
uaaguucugu cc                                                           12


<210> 19106
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 19106
uaaguucugt c                                                            11


<210> 19107
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19107
uaaguucugt                                                              10


<210> 19108
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19108
uaaguuctg                                                                9


<210> 19109
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19109
uaaguuct                                                                 8


<210> 19110
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19110
guaaguucug uccaagcccg                                                   20


<210> 19111
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19111
guaaguucug uccaagccc                                                    19


<210> 19112
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19112
guaaguucug uccaagc                                                      17


<210> 19113
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19113
guaaguucug uccaag                                                       16


<210> 19114
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19114
guaaguucug uccaa                                                        15


<210> 19115
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19115
guaaguucug ucca                                                         14


<210> 19116
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19116
guaaguucug ucc                                                          13


<210> 19117
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19117
guaaguucug tc                                                           12


<210> 19118
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19118
guaaguucug t                                                            11


<210> 19119
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19119
guaaguuctg                                                              10


<210> 19120
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19120
guaaguuct                                                                9


<210> 19121
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 19121
guaagutc                                                                 8


<210> 19122
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19122
gguaaguucu guccaagccc                                                   20


<210> 19123
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19123
gguaaguucu guccaagcc                                                    19


<210> 19124
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19124
gguaaguucu guccaag                                                      17


<210> 19125
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19125
gguaaguucu guccaa                                                       16


<210> 19126
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19126
gguaaguucu gucca                                                        15


<210> 19127
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19127
gguaaguucu gucc                                                         14


<210> 19128
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19128
gguaaguucu gtc                                                          13


<210> 19129
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19129
gguaaguucu gt                                                           12


<210> 19130
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19130
gguaaguuct g                                                            11


<210> 19131
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19131
gguaaguuct                                                              10


<210> 19132
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 19132
gguaagutc                                                                9


<210> 19133
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19133
gguaagtt                                                                 8


<210> 19134
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19134
cgguaaguuc uguccaagcc                                                   20


<210> 19135
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19135
cgguaaguuc uguccaagc                                                    19


<210> 19136
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19136
cgguaaguuc uguccaag                                                     18


<210> 19137
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19137
cgguaaguuc uguccaa                                                      17


<210> 19138
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19138
cgguaaguuc ugucca                                                       16


<210> 19139
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19139
cgguaaguuc ugucc                                                        15


<210> 19140
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19140
cgguaaguuc ugtc                                                         14


<210> 19141
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19141
cgguaaguuc ugt                                                          13


<210> 19142
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19142
cgguaaguuc tg                                                           12


<210> 19143
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19143
cgguaaguuc t                                                            11


<210> 19144
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 19144
cgguaagutc                                                              10


<210> 19145
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19145
cgguaagtt                                                                9


<210> 19146
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19146
cgguaagt                                                                 8


<210> 19147
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19147
ucgguaaguu cuguccaagc                                                   20


<210> 19148
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19148
ucgguaaguu cuguccaag                                                    19


<210> 19149
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19149
ucgguaaguu cuguccaa                                                     18


<210> 19150
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19150
ucgguaaguu cugucca                                                      17


<210> 19151
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19151
ucgguaaguu cugucc                                                       16


<210> 19152
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19152
ucgguaaguu cugtc                                                        15


<210> 19153
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19153
ucgguaaguu cugt                                                         14


<210> 19154
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19154
ucgguaaguu ctg                                                          13


<210> 19155
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19155
ucgguaaguu ct                                                           12


<210> 19156
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 19156
ucgguaagut c                                                            11


<210> 19157
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19157
ucgguaagtt                                                              10


<210> 19158
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19158
ucgguaagt                                                                9


<210> 19159
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19159
gucgguaagu ucuguccaag                                                   20


<210> 19160
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19160
gucgguaagu ucuguccaa                                                    19


<210> 19161
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19161
gucgguaagu ucugucca                                                     18


<210> 19162
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19162
gucgguaagu ucugucc                                                      17


<210> 19163
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19163
gucgguaagu ucugtc                                                       16


<210> 19164
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19164
gucgguaagu ucugt                                                        15


<210> 19165
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19165
gucgguaagu uctg                                                         14


<210> 19166
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19166
gucgguaagu uct                                                          13


<210> 19167
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19167
gucgguaagu tc                                                           12


<210> 19168
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19168
gucgguaagt t                                                            11


<210> 19169
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19169
gucgguaagt                                                              10


<210> 19170
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19170
agucgguaag uucuguccaa                                                   20


<210> 19171
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19171
agucgguaag uucugucca                                                    19


<210> 19172
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19172
agucgguaag uucugtc                                                      17


<210> 19173
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19173
agucgguaag uucugt                                                       16


<210> 19174
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19174
agucgguaag uuctg                                                        15


<210> 19175
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19175
agucgguaag uuct                                                         14


<210> 19176
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19176
agucgguaag utc                                                          13


<210> 19177
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19177
agucgguaag tt                                                           12


<210> 19178
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19178
agucgguaag t                                                            11


<210> 19179
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19179
cagucgguaa guucugucca                                                   20


<210> 19180
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19180
cagucgguaa guucugucc                                                    19


<210> 19181
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19181
cagucgguaa guucugtc                                                     18


<210> 19182
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19182
cagucgguaa guucugt                                                      17


<210> 19183
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19183
cagucgguaa guuctg                                                       16


<210> 19184
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19184
cagucgguaa guuct                                                        15


<210> 19185
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19185
cagucgguaa gutc                                                         14


<210> 19186
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19186
cagucgguaa gtt                                                          13


<210> 19187
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19187
cagucgguaa gt                                                           12


<210> 19188
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19188
ccagucggua aguucugucc                                                   20


<210> 19189
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19189
ccagucggua aguucugtc                                                    19


<210> 19190
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19190
ccagucggua aguucugt                                                     18


<210> 19191
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19191
ccagucggua aguuctg                                                      17


<210> 19192
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19192
ccagucggua aguuct                                                       16


<210> 19193
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19193
ccagucggua agutc                                                        15


<210> 19194
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19194
ccagucggua agtt                                                         14


<210> 19195
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19195
ccagucggua agt                                                          13


<210> 19196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19196
gccagucggu aaguucugtc                                                   20


<210> 19197
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19197
gccagucggu aaguucugt                                                    19


<210> 19198
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19198
gccagucggu aaguuctg                                                     18


<210> 19199
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19199
gccagucggu aaguuct                                                      17


<210> 19200
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19200
gccagucggu aagutc                                                       16


<210> 19201
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19201
gccagucggu aagtt                                                        15


<210> 19202
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19202
gccagucggu aagt                                                         14


<210> 19203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19203
ucaaggaaga uggcauuuct                                                   20


<210> 19204
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19204
ucaaggaaga uggcauuucu ag                                                22


<210> 19205
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19205
ucaaggaaga uggcat                                                       16


<210> 19206
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19206
gaagauggca uuuct                                                        15


<210> 19207
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19207
ucaaggaaga uggcauuuct a                                                 21


<210> 19208
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19208
ucaaggaaga uggcauutc                                                    19


<210> 19209
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19209
ucaaggaaga uggcautt                                                     18


<210> 19210
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19210
ucaaggaaga uggcatt                                                      17


<210> 19211
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19211
ucaaggaaga uggca                                                        15


<210> 19212
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19212
ucaaggaaga uggc                                                         14


<210> 19213
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19213
ucaaggaaga ugg                                                          13


<210> 19214
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19214
ucaaggaaga tg                                                           12


<210> 19215
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19215
ucaaggaaga t                                                            11


<210> 19216
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19216
ucaaggaaga                                                              10


<210> 19217
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19217
ucaaggaag                                                                9


<210> 19218
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19218
caaggaagau ggcauuucua g                                                 21


<210> 19219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19219
caaggaagau ggcauuucta                                                   20


<210> 19220
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19220
caaggaagau ggcauuuct                                                    19


<210> 19221
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19221
caaggaagau ggcauutc                                                     18


<210> 19222
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19222
caaggaagau ggcautt                                                      17


<210> 19223
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19223
caaggaagau ggcatt                                                       16


<210> 19224
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19224
caaggaagau ggcat                                                        15


<210> 19225
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19225
caaggaagau ggca                                                         14


<210> 19226
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19226
caaggaagau ggc                                                          13


<210> 19227
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19227
caaggaagau gg                                                           12


<210> 19228
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19228
caaggaagat g                                                            11


<210> 19229
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19229
caaggaagat                                                              10


<210> 19230
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19230
caaggaaga                                                                9


<210> 19231
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19231
caaggaag                                                                 8


<210> 19232
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19232
aaggaagaug gcauuucuag                                                   20


<210> 19233
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19233
aaggaagaug gcauuucta                                                    19


<210> 19234
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19234
aaggaagaug gcauuuct                                                     18


<210> 19235
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19235
aaggaagaug gcauutc                                                      17


<210> 19236
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19236
aaggaagaug gcautt                                                       16


<210> 19237
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19237
aaggaagaug gcatt                                                        15


<210> 19238
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19238
aaggaagaug gcat                                                         14


<210> 19239
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19239
aaggaagaug gca                                                          13


<210> 19240
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19240
aaggaagaug gc                                                           12


<210> 19241
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19241
aaggaagaug g                                                            11


<210> 19242
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19242
aaggaagatg                                                              10


<210> 19243
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19243
aaggaagat                                                                9


<210> 19244
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19244
aaggaaga                                                                 8


<210> 19245
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19245
aggaagaugg cauuucuag                                                    19


<210> 19246
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19246
aggaagaugg cauuucta                                                     18


<210> 19247
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19247
aggaagaugg cauuuct                                                      17


<210> 19248
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19248
aggaagaugg cauutc                                                       16


<210> 19249
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19249
aggaagaugg cautt                                                        15


<210> 19250
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19250
aggaagaugg catt                                                         14


<210> 19251
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19251
aggaagaugg cat                                                          13


<210> 19252
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19252
aggaagaugg ca                                                           12


<210> 19253
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19253
aggaagaugg                                                              10


<210> 19254
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19254
aggaagatg                                                                9


<210> 19255
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19255
aggaagat                                                                 8


<210> 19256
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19256
ggaagauggc auuucuag                                                     18


<210> 19257
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19257
ggaagauggc auuucta                                                      17


<210> 19258
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19258
ggaagauggc auuuct                                                       16


<210> 19259
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19259
ggaagauggc auutc                                                        15


<210> 19260
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19260
ggaagauggc autt                                                         14


<210> 19261
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19261
ggaagauggc att                                                          13


<210> 19262
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19262
ggaagauggc at                                                           12


<210> 19263
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19263
ggaagauggc a                                                            11


<210> 19264
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 19264
ggaagauggc                                                              10


<210> 19265
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19265
ggaagatg                                                                 8


<210> 19266
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19266
gaagauggca uuucuag                                                      17


<210> 19267
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19267
gaagauggca uuucta                                                       16


<210> 19268
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19268
gaagauggca uutc                                                         14


<210> 19269
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19269
gaagauggca utt                                                          13


<210> 19270
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19270
gaagauggca tt                                                           12


<210> 19271
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19271
gaagauggca t                                                            11


<210> 19272
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19272
gaagauggca                                                              10


<210> 19273
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 19273
gaagauggc                                                                9


<210> 19274
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19274
gaagaugg                                                                 8


<210> 19275
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19275
aagauggcau uucuag                                                       16


<210> 19276
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19276
aagauggcau uucta                                                        15


<210> 19277
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19277
aagauggcau uuct                                                         14


<210> 19278
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19278
aagauggcau utc                                                          13


<210> 19279
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19279
aagauggcau tt                                                           12


<210> 19280
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19280
aagauggcat t                                                            11


<210> 19281
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19281
aagauggcat                                                              10


<210> 19282
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19282
aagauggca                                                                9


<210> 19283
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 19283
aagauggc                                                                 8


<210> 19284
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19284
agauggcauu ucuag                                                        15


<210> 19285
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19285
agauggcauu ucta                                                         14


<210> 19286
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19286
agauggcauu uct                                                          13


<210> 19287
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19287
agauggcauu tc                                                           12


<210> 19288
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19288
agauggcaut t                                                            11


<210> 19289
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19289
agauggcatt                                                              10


<210> 19290
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19290
agauggcat                                                                9


<210> 19291
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19291
agauggca                                                                 8


<210> 19292
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 19292
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 19293
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 19293
cuccaacauc aaggaagaug gcauuucta                                         29


<210> 19294
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 19294
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 19295
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<400> 19295
cuccaacauc aaggaagaug gcauutc                                           27


<210> 19296
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 19296
cuccaacauc aaggaagaug gcautt                                            26


<210> 19297
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 19297
cuccaacauc aaggaagaug gcatt                                             25


<210> 19298
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19298
cuccaacauc aaggaagaug gcat                                              24


<210> 19299
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19299
cuccaacauc aaggaagaug gca                                               23


<210> 19300
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 19300
cuccaacauc aaggaagaug gc                                                22


<210> 19301
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19301
cuccaacauc aaggaagaug g                                                 21


<210> 19302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19302
cuccaacauc aaggaagatg                                                   20


<210> 19303
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19303
cuccaacauc aaggaagat                                                    19


<210> 19304
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19304
cuccaacauc aaggaaga                                                     18


<210> 19305
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19305
cuccaacauc aaggaag                                                      17


<210> 19306
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 19306
uccaacauca aggaagaugg cauuucuag                                         29


<210> 19307
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 19307
uccaacauca aggaagaugg cauuucta                                          28


<210> 19308
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 19308
uccaacauca aggaagaugg cauuuct                                           27


<210> 19309
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<400> 19309
uccaacauca aggaagaugg cauutc                                            26


<210> 19310
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 19310
uccaacauca aggaagaugg cautt                                             25


<210> 19311
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19311
uccaacauca aggaagaugg catt                                              24


<210> 19312
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19312
uccaacauca aggaagaugg cat                                               23


<210> 19313
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19313
uccaacauca aggaagaugg ca                                                22


<210> 19314
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 19314
uccaacauca aggaagaugg c                                                 21


<210> 19315
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19315
uccaacauca aggaagaugg                                                   20


<210> 19316
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19316
uccaacauca aggaagatg                                                    19


<210> 19317
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19317
uccaacauca aggaagat                                                     18


<210> 19318
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19318
uccaacauca aggaaga                                                      17


<210> 19319
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19319
uccaacauca aggaag                                                       16


<210> 19320
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 19320
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 19321
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 19321
ccaacaucaa ggaagauggc auuucta                                           27


<210> 19322
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 19322
ccaacaucaa ggaagauggc auuuct                                            26


<210> 19323
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<400> 19323
ccaacaucaa ggaagauggc auutc                                             25


<210> 19324
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19324
ccaacaucaa ggaagauggc autt                                              24


<210> 19325
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19325
ccaacaucaa ggaagauggc att                                               23


<210> 19326
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19326
ccaacaucaa ggaagauggc at                                                22


<210> 19327
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19327
ccaacaucaa ggaagauggc a                                                 21


<210> 19328
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19328
ccaacaucaa ggaagauggc                                                   20


<210> 19329
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19329
ccaacaucaa ggaagaugg                                                    19


<210> 19330
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19330
ccaacaucaa ggaagatg                                                     18


<210> 19331
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19331
ccaacaucaa ggaagat                                                      17


<210> 19332
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19332
ccaacaucaa ggaaga                                                       16


<210> 19333
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19333
ccaacaucaa ggaag                                                        15


<210> 19334
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 19334
caacaucaag gaagauggca uuucuag                                           27


<210> 19335
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 19335
caacaucaag gaagauggca uuucta                                            26


<210> 19336
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 19336
caacaucaag gaagauggca uuuct                                             25


<210> 19337
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<400> 19337
caacaucaag gaagauggca uutc                                              24


<210> 19338
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19338
caacaucaag gaagauggca utt                                               23


<210> 19339
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19339
caacaucaag gaagauggca tt                                                22


<210> 19340
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19340
caacaucaag gaagauggca t                                                 21


<210> 19341
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19341
caacaucaag gaagauggca                                                   20


<210> 19342
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19342
caacaucaag gaagauggc                                                    19


<210> 19343
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19343
caacaucaag gaagaugg                                                     18


<210> 19344
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19344
caacaucaag gaagatg                                                      17


<210> 19345
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19345
caacaucaag gaagat                                                       16


<210> 19346
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19346
caacaucaag gaaga                                                        15


<210> 19347
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19347
caacaucaag gaag                                                         14


<210> 19348
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 19348
aacaucaagg aagauggcau uucuag                                            26


<210> 19349
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 19349
aacaucaagg aagauggcau uucta                                             25


<210> 19350
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19350
aacaucaagg aagauggcau uuct                                              24


<210> 19351
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 19351
aacaucaagg aagauggcau utc                                               23


<210> 19352
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19352
aacaucaagg aagauggcau tt                                                22


<210> 19353
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19353
aacaucaagg aagauggcat t                                                 21


<210> 19354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19354
aacaucaagg aagauggcat                                                   20


<210> 19355
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19355
aacaucaagg aagauggca                                                    19


<210> 19356
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19356
aacaucaagg aagauggc                                                     18


<210> 19357
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19357
aacaucaagg aagaugg                                                      17


<210> 19358
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19358
aacaucaagg aagatg                                                       16


<210> 19359
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19359
aacaucaagg aagat                                                        15


<210> 19360
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19360
aacaucaagg aaga                                                         14


<210> 19361
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19361
aacaucaagg aag                                                          13


<210> 19362
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 19362
acaucaagga agauggcauu ucuag                                             25


<210> 19363
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19363
acaucaagga agauggcauu ucta                                              24


<210> 19364
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19364
acaucaagga agauggcauu uct                                               23


<210> 19365
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 19365
acaucaagga agauggcauu tc                                                22


<210> 19366
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19366
acaucaagga agauggcaut t                                                 21


<210> 19367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19367
acaucaagga agauggcatt                                                   20


<210> 19368
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19368
acaucaagga agauggcat                                                    19


<210> 19369
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19369
acaucaagga agauggca                                                     18


<210> 19370
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19370
acaucaagga agauggc                                                      17


<210> 19371
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19371
acaucaagga agaugg                                                       16


<210> 19372
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19372
acaucaagga agatg                                                        15


<210> 19373
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19373
acaucaagga agat                                                         14


<210> 19374
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19374
acaucaagga aga                                                          13


<210> 19375
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19375
acaucaagga ag                                                           12


<210> 19376
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19376
caucaaggaa gauggcauuu cuag                                              24


<210> 19377
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19377
caucaaggaa gauggcauuu cta                                               23


<210> 19378
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19378
caucaaggaa gauggcauuu ct                                                22


<210> 19379
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 19379
caucaaggaa gauggcauut c                                                 21


<210> 19380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19380
caucaaggaa gauggcautt                                                   20


<210> 19381
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19381
caucaaggaa gauggcatt                                                    19


<210> 19382
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19382
caucaaggaa gauggcat                                                     18


<210> 19383
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19383
caucaaggaa gauggca                                                      17


<210> 19384
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19384
caucaaggaa gauggc                                                       16


<210> 19385
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19385
caucaaggaa gaugg                                                        15


<210> 19386
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19386
caucaaggaa gatg                                                         14


<210> 19387
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19387
caucaaggaa gat                                                          13


<210> 19388
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19388
caucaaggaa ga                                                           12


<210> 19389
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19389
caucaaggaa g                                                            11


<210> 19390
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19390
aucaaggaag auggcauuuc uag                                               23


<210> 19391
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19391
aucaaggaag auggcauuuc ta                                                22


<210> 19392
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19392
aucaaggaag auggcauuuc t                                                 21


<210> 19393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19393
aucaaggaag auggcauutc                                                   20


<210> 19394
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19394
aucaaggaag auggcautt                                                    19


<210> 19395
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19395
aucaaggaag auggcatt                                                     18


<210> 19396
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19396
aucaaggaag auggcat                                                      17


<210> 19397
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19397
aucaaggaag auggca                                                       16


<210> 19398
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19398
aucaaggaag auggc                                                        15


<210> 19399
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19399
aucaaggaag augg                                                         14


<210> 19400
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19400
aucaaggaag atg                                                          13


<210> 19401
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19401
aucaaggaag at                                                           12


<210> 19402
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19402
aucaaggaag a                                                            11


<210> 19403
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19403
aucaaggaag                                                              10


<210> 19404
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 19404
ccagagcagg uaccuccaac atc                                               23


<210> 19405
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19405
ccagagcagg uaccucca                                                     18


<210> 19406
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19406
ccucugugau uuuauaacuu gat                                               23


<210> 19407
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19407
ucacccacca ucaccct                                                      17


<210> 19408
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19408
ugauauccuc aaggucaccc                                                   20


<210> 19409
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19409
cugcuugaug aucaucucgu tg                                                22


<210> 19410
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19410
cugcuugaug aucauctc                                                     18


<210> 19411
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19411
guuuccuuag uaaccacag                                                    19


<210> 19412
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19412
guuuccuuag uaaccac                                                      17


<210> 19413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19413
ucaaggaaga uggcauuuct                                                   20


<210> 19414
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19414
ucaaggaaga uggcauuucu ag                                                22


<210> 19415
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19415
gguaaguucu guccaagc                                                     18


<210> 19416
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19416
guaaguucug uccaagcc                                                     18


<210> 19417
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19417
agucgguaag uucugucc                                                     18


<210> 19418
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19418
cuguccaagc ccgguuga                                                     18


<210> 19419
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19419
uaaguucugu ccaag                                                        15


<210> 19420
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19420
uucuguccaa gcccgguuga                                                   20


<210> 19421
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19421
uucuguccaa gcccggutg                                                    19


<210> 19422
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19422
uucuguccaa gcccggtt                                                     18


<210> 19423
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19423
uucuguccaa gcccggt                                                      17


<210> 19424
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19424
uucuguccaa gcccgg                                                       16


<210> 19425
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19425
uucuguccaa gcccg                                                        15


<210> 19426
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19426
uucuguccaa gccc                                                         14


<210> 19427
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19427
uucuguccaa gcc                                                          13


<210> 19428
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19428
uucuguccaa gc                                                           12


<210> 19429
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19429
uucuguccaa g                                                            11


<210> 19430
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19430
uucuguccaa                                                              10


<210> 19431
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19431
uucugucca                                                                9


<210> 19432
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 19432
uucugucc                                                                 8


<210> 19433
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19433
ucuguccaag cccgguuga                                                    19


<210> 19434
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19434
ucuguccaag cccggutg                                                     18


<210> 19435
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19435
ucuguccaag cccggtt                                                      17


<210> 19436
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19436
ucuguccaag cccggt                                                       16


<210> 19437
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19437
ucuguccaag cccgg                                                        15


<210> 19438
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19438
ucuguccaag cccg                                                         14


<210> 19439
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19439
ucuguccaag ccc                                                          13


<210> 19440
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19440
ucuguccaag cc                                                           12


<210> 19441
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 19441
ucuguccaag c                                                            11


<210> 19442
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19442
ucuguccaag                                                              10


<210> 19443
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19443
ucuguccaa                                                                9


<210> 19444
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19444
ucugucca                                                                 8


<210> 19445
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19445
cuguccaagc ccggutg                                                      17


<210> 19446
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19446
cuguccaagc ccggtt                                                       16


<210> 19447
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19447
cuguccaagc ccggt                                                        15


<210> 19448
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19448
cuguccaagc ccgg                                                         14


<210> 19449
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19449
cuguccaagc ccg                                                          13


<210> 19450
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19450
cuguccaagc cc                                                           12


<210> 19451
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 19451
cuguccaagc c                                                            11


<210> 19452
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 19452
cuguccaagc                                                              10


<210> 19453
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19453
cuguccaag                                                                9


<210> 19454
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19454
cuguccaa                                                                 8


<210> 19455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19455
guucugucca agcccggutg                                                   20


<210> 19456
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19456
guucugucca agcccggtt                                                    19


<210> 19457
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19457
guucugucca agcccggt                                                     18


<210> 19458
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19458
guucugucca agcccgg                                                      17


<210> 19459
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19459
guucugucca agcccg                                                       16


<210> 19460
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19460
guucugucca agccc                                                        15


<210> 19461
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19461
guucugucca agcc                                                         14


<210> 19462
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19462
guucugucca agc                                                          13


<210> 19463
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19463
guucugucca ag                                                           12


<210> 19464
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19464
guucugucca a                                                            11


<210> 19465
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19465
guucugucca                                                              10


<210> 19466
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 19466
guucugucc                                                                9


<210> 19467
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 19467
guucugtc                                                                 8


<210> 19468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19468
aguucugucc aagcccggtt                                                   20


<210> 19469
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19469
aguucugucc aagcccggt                                                    19


<210> 19470
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19470
aguucugucc aagcccgg                                                     18


<210> 19471
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19471
aguucugucc aagcccg                                                      17


<210> 19472
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19472
aguucugucc aagccc                                                       16


<210> 19473
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19473
aguucugucc aagcc                                                        15


<210> 19474
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19474
aguucugucc aagc                                                         14


<210> 19475
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19475
aguucugucc aag                                                          13


<210> 19476
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19476
aguucugucc aa                                                           12


<210> 19477
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19477
aguucugucc a                                                            11


<210> 19478
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 19478
aguucugucc                                                              10


<210> 19479
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 19479
aguucugtc                                                                9


<210> 19480
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19480
aguucugt                                                                 8


<210> 19481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19481
aaguucuguc caagcccggt                                                   20


<210> 19482
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19482
aaguucuguc caagcccgg                                                    19


<210> 19483
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19483
aaguucuguc caagcccg                                                     18


<210> 19484
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19484
aaguucuguc caagccc                                                      17


<210> 19485
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19485
aaguucuguc caagcc                                                       16


<210> 19486
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19486
aaguucuguc caagc                                                        15


<210> 19487
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19487
aaguucuguc caag                                                         14


<210> 19488
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19488
aaguucuguc caa                                                          13


<210> 19489
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19489
aaguucuguc ca                                                           12


<210> 19490
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 19490
aaguucuguc c                                                            11


<210> 19491
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 19491
aaguucugtc                                                              10


<210> 19492
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19492
aaguucugt                                                                9


<210> 19493
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19493
aaguuctg                                                                 8


<210> 19494
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19494
uaaguucugu ccaagcccgg                                                   20


<210> 19495
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19495
uaaguucugu ccaagcccg                                                    19


<210> 19496
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19496
uaaguucugu ccaagccc                                                     18


<210> 19497
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19497
uaaguucugu ccaagcc                                                      17


<210> 19498
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19498
uaaguucugu ccaagc                                                       16


<210> 19499
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19499
uaaguucugu ccaa                                                         14


<210> 19500
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19500
uaaguucugu cca                                                          13


<210> 19501
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19501
uaaguucugu cc                                                           12


<210> 19502
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 19502
uaaguucugt c                                                            11


<210> 19503
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19503
uaaguucugt                                                              10


<210> 19504
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19504
uaaguuctg                                                                9


<210> 19505
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19505
uaaguuct                                                                 8


<210> 19506
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19506
guaaguucug uccaagcccg                                                   20


<210> 19507
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19507
guaaguucug uccaagccc                                                    19


<210> 19508
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19508
guaaguucug uccaagc                                                      17


<210> 19509
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19509
guaaguucug uccaag                                                       16


<210> 19510
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19510
guaaguucug uccaa                                                        15


<210> 19511
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19511
guaaguucug ucca                                                         14


<210> 19512
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19512
guaaguucug ucc                                                          13


<210> 19513
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19513
guaaguucug tc                                                           12


<210> 19514
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19514
guaaguucug t                                                            11


<210> 19515
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19515
guaaguuctg                                                              10


<210> 19516
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19516
guaaguuct                                                                9


<210> 19517
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 19517
guaagutc                                                                 8


<210> 19518
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19518
gguaaguucu guccaagccc                                                   20


<210> 19519
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19519
gguaaguucu guccaagcc                                                    19


<210> 19520
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19520
gguaaguucu guccaag                                                      17


<210> 19521
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19521
gguaaguucu guccaa                                                       16


<210> 19522
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19522
gguaaguucu gucca                                                        15


<210> 19523
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19523
gguaaguucu gucc                                                         14


<210> 19524
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19524
gguaaguucu gtc                                                          13


<210> 19525
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19525
gguaaguucu gt                                                           12


<210> 19526
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19526
gguaaguuct g                                                            11


<210> 19527
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19527
gguaaguuct                                                              10


<210> 19528
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 19528
gguaagutc                                                                9


<210> 19529
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19529
gguaagtt                                                                 8


<210> 19530
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19530
cgguaaguuc uguccaagcc                                                   20


<210> 19531
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19531
cgguaaguuc uguccaagc                                                    19


<210> 19532
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19532
cgguaaguuc uguccaag                                                     18


<210> 19533
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19533
cgguaaguuc uguccaa                                                      17


<210> 19534
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19534
cgguaaguuc ugucca                                                       16


<210> 19535
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19535
cgguaaguuc ugucc                                                        15


<210> 19536
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19536
cgguaaguuc ugtc                                                         14


<210> 19537
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19537
cgguaaguuc ugt                                                          13


<210> 19538
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19538
cgguaaguuc tg                                                           12


<210> 19539
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19539
cgguaaguuc t                                                            11


<210> 19540
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 19540
cgguaagutc                                                              10


<210> 19541
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19541
cgguaagtt                                                                9


<210> 19542
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19542
cgguaagt                                                                 8


<210> 19543
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19543
ucgguaaguu cuguccaagc                                                   20


<210> 19544
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19544
ucgguaaguu cuguccaag                                                    19


<210> 19545
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19545
ucgguaaguu cuguccaa                                                     18


<210> 19546
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19546
ucgguaaguu cugucca                                                      17


<210> 19547
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19547
ucgguaaguu cugucc                                                       16


<210> 19548
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19548
ucgguaaguu cugtc                                                        15


<210> 19549
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19549
ucgguaaguu cugt                                                         14


<210> 19550
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19550
ucgguaaguu ctg                                                          13


<210> 19551
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19551
ucgguaaguu ct                                                           12


<210> 19552
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 19552
ucgguaagut c                                                            11


<210> 19553
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19553
ucgguaagtt                                                              10


<210> 19554
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19554
ucgguaagt                                                                9


<210> 19555
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19555
gucgguaagu ucuguccaag                                                   20


<210> 19556
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19556
gucgguaagu ucuguccaa                                                    19


<210> 19557
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19557
gucgguaagu ucugucca                                                     18


<210> 19558
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19558
gucgguaagu ucugucc                                                      17


<210> 19559
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19559
gucgguaagu ucugtc                                                       16


<210> 19560
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19560
gucgguaagu ucugt                                                        15


<210> 19561
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19561
gucgguaagu uctg                                                         14


<210> 19562
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19562
gucgguaagu uct                                                          13


<210> 19563
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19563
gucgguaagu tc                                                           12


<210> 19564
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19564
gucgguaagt t                                                            11


<210> 19565
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19565
gucgguaagt                                                              10


<210> 19566
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19566
agucgguaag uucuguccaa                                                   20


<210> 19567
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19567
agucgguaag uucugucca                                                    19


<210> 19568
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19568
agucgguaag uucugtc                                                      17


<210> 19569
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19569
agucgguaag uucugt                                                       16


<210> 19570
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19570
agucgguaag uuctg                                                        15


<210> 19571
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19571
agucgguaag uuct                                                         14


<210> 19572
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19572
agucgguaag utc                                                          13


<210> 19573
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19573
agucgguaag tt                                                           12


<210> 19574
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19574
agucgguaag t                                                            11


<210> 19575
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19575
cagucgguaa guucugucca                                                   20


<210> 19576
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19576
cagucgguaa guucugucc                                                    19


<210> 19577
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19577
cagucgguaa guucugtc                                                     18


<210> 19578
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19578
cagucgguaa guucugt                                                      17


<210> 19579
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19579
cagucgguaa guuctg                                                       16


<210> 19580
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19580
cagucgguaa guuct                                                        15


<210> 19581
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19581
cagucgguaa gutc                                                         14


<210> 19582
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19582
cagucgguaa gtt                                                          13


<210> 19583
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19583
cagucgguaa gt                                                           12


<210> 19584
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19584
ccagucggua aguucugucc                                                   20


<210> 19585
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19585
ccagucggua aguucugtc                                                    19


<210> 19586
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19586
ccagucggua aguucugt                                                     18


<210> 19587
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19587
ccagucggua aguuctg                                                      17


<210> 19588
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19588
ccagucggua aguuct                                                       16


<210> 19589
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19589
ccagucggua agutc                                                        15


<210> 19590
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19590
ccagucggua agtt                                                         14


<210> 19591
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19591
ccagucggua agt                                                          13


<210> 19592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19592
gccagucggu aaguucugtc                                                   20


<210> 19593
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19593
gccagucggu aaguucugt                                                    19


<210> 19594
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19594
gccagucggu aaguuctg                                                     18


<210> 19595
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19595
gccagucggu aaguuct                                                      17


<210> 19596
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19596
gccagucggu aagutc                                                       16


<210> 19597
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19597
gccagucggu aagtt                                                        15


<210> 19598
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19598
gccagucggu aagt                                                         14


<210> 19599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19599
ucaaggaaga uggcauuuct                                                   20


<210> 19600
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19600
ucaaggaaga uggcauuucu ag                                                22


<210> 19601
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19601
ucaaggaaga uggcat                                                       16


<210> 19602
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19602
gaagauggca uuuct                                                        15


<210> 19603
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19603
ucaaggaaga uggcauuuct a                                                 21


<210> 19604
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19604
ucaaggaaga uggcauutc                                                    19


<210> 19605
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19605
ucaaggaaga uggcautt                                                     18


<210> 19606
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19606
ucaaggaaga uggcatt                                                      17


<210> 19607
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19607
ucaaggaaga uggca                                                        15


<210> 19608
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19608
ucaaggaaga uggc                                                         14


<210> 19609
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19609
ucaaggaaga ugg                                                          13


<210> 19610
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19610
ucaaggaaga tg                                                           12


<210> 19611
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19611
ucaaggaaga t                                                            11


<210> 19612
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19612
ucaaggaaga                                                              10


<210> 19613
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19613
ucaaggaag                                                                9


<210> 19614
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19614
caaggaagau ggcauuucua g                                                 21


<210> 19615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19615
caaggaagau ggcauuucta                                                   20


<210> 19616
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19616
caaggaagau ggcauuuct                                                    19


<210> 19617
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19617
caaggaagau ggcauutc                                                     18


<210> 19618
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19618
caaggaagau ggcautt                                                      17


<210> 19619
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19619
caaggaagau ggcatt                                                       16


<210> 19620
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19620
caaggaagau ggcat                                                        15


<210> 19621
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19621
caaggaagau ggca                                                         14


<210> 19622
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19622
caaggaagau ggc                                                          13


<210> 19623
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19623
caaggaagau gg                                                           12


<210> 19624
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19624
caaggaagat g                                                            11


<210> 19625
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19625
caaggaagat                                                              10


<210> 19626
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19626
caaggaaga                                                                9


<210> 19627
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19627
caaggaag                                                                 8


<210> 19628
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19628
aaggaagaug gcauuucuag                                                   20


<210> 19629
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19629
aaggaagaug gcauuucta                                                    19


<210> 19630
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19630
aaggaagaug gcauuuct                                                     18


<210> 19631
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19631
aaggaagaug gcauutc                                                      17


<210> 19632
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19632
aaggaagaug gcautt                                                       16


<210> 19633
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19633
aaggaagaug gcatt                                                        15


<210> 19634
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19634
aaggaagaug gcat                                                         14


<210> 19635
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19635
aaggaagaug gca                                                          13


<210> 19636
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19636
aaggaagaug gc                                                           12


<210> 19637
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19637
aaggaagaug g                                                            11


<210> 19638
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19638
aaggaagatg                                                              10


<210> 19639
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19639
aaggaagat                                                                9


<210> 19640
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19640
aaggaaga                                                                 8


<210> 19641
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19641
aggaagaugg cauuucuag                                                    19


<210> 19642
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19642
aggaagaugg cauuucta                                                     18


<210> 19643
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19643
aggaagaugg cauuuct                                                      17


<210> 19644
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19644
aggaagaugg cauutc                                                       16


<210> 19645
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19645
aggaagaugg cautt                                                        15


<210> 19646
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19646
aggaagaugg catt                                                         14


<210> 19647
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19647
aggaagaugg cat                                                          13


<210> 19648
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19648
aggaagaugg ca                                                           12


<210> 19649
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19649
aggaagaugg                                                              10


<210> 19650
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19650
aggaagatg                                                                9


<210> 19651
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19651
aggaagat                                                                 8


<210> 19652
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19652
ggaagauggc auuucuag                                                     18


<210> 19653
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19653
ggaagauggc auuucta                                                      17


<210> 19654
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19654
ggaagauggc auuuct                                                       16


<210> 19655
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19655
ggaagauggc auutc                                                        15


<210> 19656
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19656
ggaagauggc autt                                                         14


<210> 19657
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19657
ggaagauggc att                                                          13


<210> 19658
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19658
ggaagauggc at                                                           12


<210> 19659
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19659
ggaagauggc a                                                            11


<210> 19660
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 19660
ggaagauggc                                                              10


<210> 19661
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19661
ggaagatg                                                                 8


<210> 19662
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19662
gaagauggca uuucuag                                                      17


<210> 19663
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19663
gaagauggca uuucta                                                       16


<210> 19664
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 19664
gaagauggca uutc                                                         14


<210> 19665
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19665
gaagauggca utt                                                          13


<210> 19666
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19666
gaagauggca tt                                                           12


<210> 19667
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19667
gaagauggca t                                                            11


<210> 19668
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19668
gaagauggca                                                              10


<210> 19669
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 19669
gaagauggc                                                                9


<210> 19670
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19670
gaagaugg                                                                 8


<210> 19671
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19671
aagauggcau uucuag                                                       16


<210> 19672
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19672
aagauggcau uucta                                                        15


<210> 19673
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19673
aagauggcau uuct                                                         14


<210> 19674
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 19674
aagauggcau utc                                                          13


<210> 19675
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19675
aagauggcau tt                                                           12


<210> 19676
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19676
aagauggcat t                                                            11


<210> 19677
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19677
aagauggcat                                                              10


<210> 19678
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19678
aagauggca                                                                9


<210> 19679
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 19679
aagauggc                                                                 8


<210> 19680
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19680
agauggcauu ucuag                                                        15


<210> 19681
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19681
agauggcauu ucta                                                         14


<210> 19682
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19682
agauggcauu uct                                                          13


<210> 19683
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 19683
agauggcauu tc                                                           12


<210> 19684
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19684
agauggcaut t                                                            11


<210> 19685
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19685
agauggcatt                                                              10


<210> 19686
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 19686
agauggcat                                                                9


<210> 19687
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 19687
agauggca                                                                 8


<210> 19688
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 19688
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 19689
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 19689
cuccaacauc aaggaagaug gcauuucta                                         29


<210> 19690
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 19690
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 19691
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<400> 19691
cuccaacauc aaggaagaug gcauutc                                           27


<210> 19692
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 19692
cuccaacauc aaggaagaug gcautt                                            26


<210> 19693
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 19693
cuccaacauc aaggaagaug gcatt                                             25


<210> 19694
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19694
cuccaacauc aaggaagaug gcat                                              24


<210> 19695
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19695
cuccaacauc aaggaagaug gca                                               23


<210> 19696
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 19696
cuccaacauc aaggaagaug gc                                                22


<210> 19697
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19697
cuccaacauc aaggaagaug g                                                 21


<210> 19698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19698
cuccaacauc aaggaagatg                                                   20


<210> 19699
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19699
cuccaacauc aaggaagat                                                    19


<210> 19700
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19700
cuccaacauc aaggaaga                                                     18


<210> 19701
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19701
cuccaacauc aaggaag                                                      17


<210> 19702
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 19702
uccaacauca aggaagaugg cauuucuag                                         29


<210> 19703
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 19703
uccaacauca aggaagaugg cauuucta                                          28


<210> 19704
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 19704
uccaacauca aggaagaugg cauuuct                                           27


<210> 19705
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<400> 19705
uccaacauca aggaagaugg cauutc                                            26


<210> 19706
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 19706
uccaacauca aggaagaugg cautt                                             25


<210> 19707
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19707
uccaacauca aggaagaugg catt                                              24


<210> 19708
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19708
uccaacauca aggaagaugg cat                                               23


<210> 19709
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19709
uccaacauca aggaagaugg ca                                                22


<210> 19710
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 19710
uccaacauca aggaagaugg c                                                 21


<210> 19711
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19711
uccaacauca aggaagaugg                                                   20


<210> 19712
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19712
uccaacauca aggaagatg                                                    19


<210> 19713
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19713
uccaacauca aggaagat                                                     18


<210> 19714
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19714
uccaacauca aggaaga                                                      17


<210> 19715
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19715
uccaacauca aggaag                                                       16


<210> 19716
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 19716
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 19717
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 19717
ccaacaucaa ggaagauggc auuucta                                           27


<210> 19718
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 19718
ccaacaucaa ggaagauggc auuuct                                            26


<210> 19719
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<400> 19719
ccaacaucaa ggaagauggc auutc                                             25


<210> 19720
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19720
ccaacaucaa ggaagauggc autt                                              24


<210> 19721
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19721
ccaacaucaa ggaagauggc att                                               23


<210> 19722
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19722
ccaacaucaa ggaagauggc at                                                22


<210> 19723
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19723
ccaacaucaa ggaagauggc a                                                 21


<210> 19724
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19724
ccaacaucaa ggaagauggc                                                   20


<210> 19725
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19725
ccaacaucaa ggaagaugg                                                    19


<210> 19726
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19726
ccaacaucaa ggaagatg                                                     18


<210> 19727
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19727
ccaacaucaa ggaagat                                                      17


<210> 19728
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19728
ccaacaucaa ggaaga                                                       16


<210> 19729
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19729
ccaacaucaa ggaag                                                        15


<210> 19730
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 19730
caacaucaag gaagauggca uuucuag                                           27


<210> 19731
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 19731
caacaucaag gaagauggca uuucta                                            26


<210> 19732
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 19732
caacaucaag gaagauggca uuuct                                             25


<210> 19733
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<400> 19733
caacaucaag gaagauggca uutc                                              24


<210> 19734
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19734
caacaucaag gaagauggca utt                                               23


<210> 19735
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19735
caacaucaag gaagauggca tt                                                22


<210> 19736
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19736
caacaucaag gaagauggca t                                                 21


<210> 19737
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19737
caacaucaag gaagauggca                                                   20


<210> 19738
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 19738
caacaucaag gaagauggc                                                    19


<210> 19739
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19739
caacaucaag gaagaugg                                                     18


<210> 19740
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19740
caacaucaag gaagatg                                                      17


<210> 19741
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19741
caacaucaag gaagat                                                       16


<210> 19742
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19742
caacaucaag gaaga                                                        15


<210> 19743
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19743
caacaucaag gaag                                                         14


<210> 19744
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 19744
aacaucaagg aagauggcau uucuag                                            26


<210> 19745
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 19745
aacaucaagg aagauggcau uucta                                             25


<210> 19746
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19746
aacaucaagg aagauggcau uuct                                              24


<210> 19747
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 19747
aacaucaagg aagauggcau utc                                               23


<210> 19748
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19748
aacaucaagg aagauggcau tt                                                22


<210> 19749
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19749
aacaucaagg aagauggcat t                                                 21


<210> 19750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19750
aacaucaagg aagauggcat                                                   20


<210> 19751
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19751
aacaucaagg aagauggca                                                    19


<210> 19752
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19752
aacaucaagg aagauggc                                                     18


<210> 19753
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19753
aacaucaagg aagaugg                                                      17


<210> 19754
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19754
aacaucaagg aagatg                                                       16


<210> 19755
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19755
aacaucaagg aagat                                                        15


<210> 19756
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19756
aacaucaagg aaga                                                         14


<210> 19757
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19757
aacaucaagg aag                                                          13


<210> 19758
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 19758
acaucaagga agauggcauu ucuag                                             25


<210> 19759
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19759
acaucaagga agauggcauu ucta                                              24


<210> 19760
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19760
acaucaagga agauggcauu uct                                               23


<210> 19761
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 19761
acaucaagga agauggcauu tc                                                22


<210> 19762
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19762
acaucaagga agauggcaut t                                                 21


<210> 19763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19763
acaucaagga agauggcatt                                                   20


<210> 19764
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19764
acaucaagga agauggcat                                                    19


<210> 19765
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19765
acaucaagga agauggca                                                     18


<210> 19766
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19766
acaucaagga agauggc                                                      17


<210> 19767
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19767
acaucaagga agaugg                                                       16


<210> 19768
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19768
acaucaagga agatg                                                        15


<210> 19769
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19769
acaucaagga agat                                                         14


<210> 19770
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19770
acaucaagga aga                                                          13


<210> 19771
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19771
acaucaagga ag                                                           12


<210> 19772
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 19772
caucaaggaa gauggcauuu cuag                                              24


<210> 19773
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19773
caucaaggaa gauggcauuu cta                                               23


<210> 19774
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19774
caucaaggaa gauggcauuu ct                                                22


<210> 19775
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 19775
caucaaggaa gauggcauut c                                                 21


<210> 19776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 19776
caucaaggaa gauggcautt                                                   20


<210> 19777
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19777
caucaaggaa gauggcatt                                                    19


<210> 19778
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19778
caucaaggaa gauggcat                                                     18


<210> 19779
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19779
caucaaggaa gauggca                                                      17


<210> 19780
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 19780
caucaaggaa gauggc                                                       16


<210> 19781
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 19781
caucaaggaa gaugg                                                        15


<210> 19782
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19782
caucaaggaa gatg                                                         14


<210> 19783
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19783
caucaaggaa gat                                                          13


<210> 19784
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19784
caucaaggaa ga                                                           12


<210> 19785
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19785
caucaaggaa g                                                            11


<210> 19786
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19786
aucaaggaag auggcauuuc uag                                               23


<210> 19787
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19787
aucaaggaag auggcauuuc ta                                                22


<210> 19788
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 19788
aucaaggaag auggcauuuc t                                                 21


<210> 19789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19789
aucaaggaag auggcauutc                                                   20


<210> 19790
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19790
aucaaggaag auggcautt                                                    19


<210> 19791
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19791
aucaaggaag auggcatt                                                     18


<210> 19792
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19792
aucaaggaag auggcat                                                      17


<210> 19793
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 19793
aucaaggaag auggca                                                       16


<210> 19794
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 19794
aucaaggaag auggc                                                        15


<210> 19795
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 19795
aucaaggaag augg                                                         14


<210> 19796
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 19796
aucaaggaag atg                                                          13


<210> 19797
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 19797
aucaaggaag at                                                           12


<210> 19798
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 19798
aucaaggaag a                                                            11


<210> 19799
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 19799
aucaaggaag                                                              10


<210> 19800
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 19800
ccagagcagg uaccuccaac atc                                               23


<210> 19801
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 19801
ccagagcagg uaccucca                                                     18


<210> 19802
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 19802
ccucugugau uuuauaacuu gat                                               23


<210> 19803
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 19803
ucacccacca ucaccct                                                      17


<210> 19804
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 19804
ugauauccuc aaggucaccc                                                   20


<210> 19805
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 19805
cugcuugaug aucaucucgu tg                                                22


<210> 19806
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 19806
cugcuugaug aucauctc                                                     18


<210> 19807
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 19807
guuuccuuag uaaccacag                                                    19


<210> 19808
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 19808
guuuccuuag uaaccac                                                      17


<210> 19809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19809
ucaaggaaga uggcauuuct                                                   20


<210> 19810
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19810
ucaaggaaga uggcauuucu ag                                                22


<210> 19811
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19811
gguaaguucu guccaagc                                                     18


<210> 19812
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19812
guaaguucug uccaagcc                                                     18


<210> 19813
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19813
agucgguaag uucugucc                                                     18


<210> 19814
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19814
cuguccaagc ccgguuga                                                     18


<210> 19815
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19815
uaaguucugu ccaag                                                        15


<210> 19816
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19816
uucuguccaa gcccgguuga                                                   20


<210> 19817
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19817
uucuguccaa gcccggutg                                                    19


<210> 19818
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19818
uucuguccaa gcccggtt                                                     18


<210> 19819
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19819
uucuguccaa gcccggt                                                      17


<210> 19820
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19820
uucuguccaa gcccgg                                                       16


<210> 19821
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19821
uucuguccaa gcccg                                                        15


<210> 19822
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19822
uucuguccaa gccc                                                         14


<210> 19823
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19823
uucuguccaa gcc                                                          13


<210> 19824
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19824
uucuguccaa gc                                                           12


<210> 19825
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19825
uucuguccaa g                                                            11


<210> 19826
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19826
uucuguccaa                                                              10


<210> 19827
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19827
uucugucca                                                                9


<210> 19828
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19828
uucugucc                                                                 8


<210> 19829
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19829
ucuguccaag cccgguuga                                                    19


<210> 19830
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19830
ucuguccaag cccggutg                                                     18


<210> 19831
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19831
ucuguccaag cccggtt                                                      17


<210> 19832
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19832
ucuguccaag cccggt                                                       16


<210> 19833
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19833
ucuguccaag cccgg                                                        15


<210> 19834
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19834
ucuguccaag cccg                                                         14


<210> 19835
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19835
ucuguccaag ccc                                                          13


<210> 19836
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19836
ucuguccaag cc                                                           12


<210> 19837
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19837
ucuguccaag c                                                            11


<210> 19838
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19838
ucuguccaag                                                              10


<210> 19839
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19839
ucuguccaa                                                                9


<210> 19840
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19840
ucugucca                                                                 8


<210> 19841
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19841
cuguccaagc ccggutg                                                      17


<210> 19842
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19842
cuguccaagc ccggtt                                                       16


<210> 19843
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19843
cuguccaagc ccggt                                                        15


<210> 19844
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19844
cuguccaagc ccgg                                                         14


<210> 19845
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19845
cuguccaagc ccg                                                          13


<210> 19846
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19846
cuguccaagc cc                                                           12


<210> 19847
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19847
cuguccaagc c                                                            11


<210> 19848
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19848
cuguccaagc                                                              10


<210> 19849
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19849
cuguccaag                                                                9


<210> 19850
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19850
cuguccaa                                                                 8


<210> 19851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19851
guucugucca agcccggutg                                                   20


<210> 19852
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19852
guucugucca agcccggtt                                                    19


<210> 19853
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19853
guucugucca agcccggt                                                     18


<210> 19854
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19854
guucugucca agcccgg                                                      17


<210> 19855
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19855
guucugucca agcccg                                                       16


<210> 19856
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19856
guucugucca agccc                                                        15


<210> 19857
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19857
guucugucca agcc                                                         14


<210> 19858
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19858
guucugucca agc                                                          13


<210> 19859
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19859
guucugucca ag                                                           12


<210> 19860
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19860
guucugucca a                                                            11


<210> 19861
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19861
guucugucca                                                              10


<210> 19862
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19862
guucugucc                                                                9


<210> 19863
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19863
guucugtc                                                                 8


<210> 19864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19864
aguucugucc aagcccggtt                                                   20


<210> 19865
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19865
aguucugucc aagcccggt                                                    19


<210> 19866
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19866
aguucugucc aagcccgg                                                     18


<210> 19867
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19867
aguucugucc aagcccg                                                      17


<210> 19868
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19868
aguucugucc aagccc                                                       16


<210> 19869
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19869
aguucugucc aagcc                                                        15


<210> 19870
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19870
aguucugucc aagc                                                         14


<210> 19871
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19871
aguucugucc aag                                                          13


<210> 19872
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19872
aguucugucc aa                                                           12


<210> 19873
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19873
aguucugucc a                                                            11


<210> 19874
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19874
aguucugucc                                                              10


<210> 19875
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19875
aguucugtc                                                                9


<210> 19876
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19876
aguucugt                                                                 8


<210> 19877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19877
aaguucuguc caagcccggt                                                   20


<210> 19878
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19878
aaguucuguc caagcccgg                                                    19


<210> 19879
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19879
aaguucuguc caagcccg                                                     18


<210> 19880
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19880
aaguucuguc caagccc                                                      17


<210> 19881
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19881
aaguucuguc caagcc                                                       16


<210> 19882
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19882
aaguucuguc caagc                                                        15


<210> 19883
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19883
aaguucuguc caag                                                         14


<210> 19884
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19884
aaguucuguc caa                                                          13


<210> 19885
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19885
aaguucuguc ca                                                           12


<210> 19886
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19886
aaguucuguc c                                                            11


<210> 19887
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19887
aaguucugtc                                                              10


<210> 19888
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19888
aaguucugt                                                                9


<210> 19889
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19889
aaguuctg                                                                 8


<210> 19890
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19890
uaaguucugu ccaagcccgg                                                   20


<210> 19891
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19891
uaaguucugu ccaagcccg                                                    19


<210> 19892
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19892
uaaguucugu ccaagccc                                                     18


<210> 19893
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19893
uaaguucugu ccaagcc                                                      17


<210> 19894
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19894
uaaguucugu ccaagc                                                       16


<210> 19895
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19895
uaaguucugu ccaa                                                         14


<210> 19896
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19896
uaaguucugu cca                                                          13


<210> 19897
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19897
uaaguucugu cc                                                           12


<210> 19898
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19898
uaaguucugt c                                                            11


<210> 19899
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19899
uaaguucugt                                                              10


<210> 19900
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19900
uaaguuctg                                                                9


<210> 19901
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19901
uaaguuct                                                                 8


<210> 19902
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19902
guaaguucug uccaagcccg                                                   20


<210> 19903
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19903
guaaguucug uccaagccc                                                    19


<210> 19904
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19904
guaaguucug uccaagc                                                      17


<210> 19905
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19905
guaaguucug uccaag                                                       16


<210> 19906
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19906
guaaguucug uccaa                                                        15


<210> 19907
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19907
guaaguucug ucca                                                         14


<210> 19908
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19908
guaaguucug ucc                                                          13


<210> 19909
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19909
guaaguucug tc                                                           12


<210> 19910
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19910
guaaguucug t                                                            11


<210> 19911
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19911
guaaguuctg                                                              10


<210> 19912
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19912
guaaguuct                                                                9


<210> 19913
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19913
guaagutc                                                                 8


<210> 19914
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19914
gguaaguucu guccaagccc                                                   20


<210> 19915
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19915
gguaaguucu guccaagcc                                                    19


<210> 19916
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19916
gguaaguucu guccaag                                                      17


<210> 19917
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19917
gguaaguucu guccaa                                                       16


<210> 19918
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19918
gguaaguucu gucca                                                        15


<210> 19919
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19919
gguaaguucu gucc                                                         14


<210> 19920
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19920
gguaaguucu gtc                                                          13


<210> 19921
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19921
gguaaguucu gt                                                           12


<210> 19922
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19922
gguaaguuct g                                                            11


<210> 19923
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19923
gguaaguuct                                                              10


<210> 19924
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19924
gguaagutc                                                                9


<210> 19925
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19925
gguaagtt                                                                 8


<210> 19926
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19926
cgguaaguuc uguccaagcc                                                   20


<210> 19927
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19927
cgguaaguuc uguccaagc                                                    19


<210> 19928
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19928
cgguaaguuc uguccaag                                                     18


<210> 19929
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19929
cgguaaguuc uguccaa                                                      17


<210> 19930
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19930
cgguaaguuc ugucca                                                       16


<210> 19931
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19931
cgguaaguuc ugucc                                                        15


<210> 19932
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19932
cgguaaguuc ugtc                                                         14


<210> 19933
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19933
cgguaaguuc ugt                                                          13


<210> 19934
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19934
cgguaaguuc tg                                                           12


<210> 19935
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19935
cgguaaguuc t                                                            11


<210> 19936
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19936
cgguaagutc                                                              10


<210> 19937
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19937
cgguaagtt                                                                9


<210> 19938
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19938
cgguaagt                                                                 8


<210> 19939
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19939
ucgguaaguu cuguccaagc                                                   20


<210> 19940
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19940
ucgguaaguu cuguccaag                                                    19


<210> 19941
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19941
ucgguaaguu cuguccaa                                                     18


<210> 19942
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19942
ucgguaaguu cugucca                                                      17


<210> 19943
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19943
ucgguaaguu cugucc                                                       16


<210> 19944
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19944
ucgguaaguu cugtc                                                        15


<210> 19945
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19945
ucgguaaguu cugt                                                         14


<210> 19946
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19946
ucgguaaguu ctg                                                          13


<210> 19947
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19947
ucgguaaguu ct                                                           12


<210> 19948
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19948
ucgguaagut c                                                            11


<210> 19949
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19949
ucgguaagtt                                                              10


<210> 19950
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19950
ucgguaagt                                                                9


<210> 19951
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19951
gucgguaagu ucuguccaag                                                   20


<210> 19952
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19952
gucgguaagu ucuguccaa                                                    19


<210> 19953
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19953
gucgguaagu ucugucca                                                     18


<210> 19954
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19954
gucgguaagu ucugucc                                                      17


<210> 19955
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19955
gucgguaagu ucugtc                                                       16


<210> 19956
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19956
gucgguaagu ucugt                                                        15


<210> 19957
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19957
gucgguaagu uctg                                                         14


<210> 19958
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19958
gucgguaagu uct                                                          13


<210> 19959
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19959
gucgguaagu tc                                                           12


<210> 19960
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19960
gucgguaagt t                                                            11


<210> 19961
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19961
gucgguaagt                                                              10


<210> 19962
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19962
agucgguaag uucuguccaa                                                   20


<210> 19963
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19963
agucgguaag uucugucca                                                    19


<210> 19964
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19964
agucgguaag uucugtc                                                      17


<210> 19965
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19965
agucgguaag uucugt                                                       16


<210> 19966
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19966
agucgguaag uuctg                                                        15


<210> 19967
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19967
agucgguaag uuct                                                         14


<210> 19968
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19968
agucgguaag utc                                                          13


<210> 19969
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19969
agucgguaag tt                                                           12


<210> 19970
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19970
agucgguaag t                                                            11


<210> 19971
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19971
cagucgguaa guucugucca                                                   20


<210> 19972
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19972
cagucgguaa guucugucc                                                    19


<210> 19973
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19973
cagucgguaa guucugtc                                                     18


<210> 19974
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19974
cagucgguaa guucugt                                                      17


<210> 19975
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19975
cagucgguaa guuctg                                                       16


<210> 19976
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19976
cagucgguaa guuct                                                        15


<210> 19977
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19977
cagucgguaa gutc                                                         14


<210> 19978
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19978
cagucgguaa gtt                                                          13


<210> 19979
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19979
cagucgguaa gt                                                           12


<210> 19980
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19980
ccagucggua aguucugucc                                                   20


<210> 19981
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19981
ccagucggua aguucugtc                                                    19


<210> 19982
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19982
ccagucggua aguucugt                                                     18


<210> 19983
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19983
ccagucggua aguuctg                                                      17


<210> 19984
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19984
ccagucggua aguuct                                                       16


<210> 19985
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19985
ccagucggua agutc                                                        15


<210> 19986
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19986
ccagucggua agtt                                                         14


<210> 19987
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19987
ccagucggua agt                                                          13


<210> 19988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19988
gccagucggu aaguucugtc                                                   20


<210> 19989
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19989
gccagucggu aaguucugt                                                    19


<210> 19990
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19990
gccagucggu aaguuctg                                                     18


<210> 19991
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19991
gccagucggu aaguuct                                                      17


<210> 19992
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19992
gccagucggu aagutc                                                       16


<210> 19993
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19993
gccagucggu aagtt                                                        15


<210> 19994
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19994
gccagucggu aagt                                                         14


<210> 19995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19995
ucaaggaaga uggcauuuct                                                   20


<210> 19996
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19996
ucaaggaaga uggcauuucu ag                                                22


<210> 19997
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19997
ucaaggaaga uggcat                                                       16


<210> 19998
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19998
gaagauggca uuuct                                                        15


<210> 19999
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 19999
ucaaggaaga uggcauuuct a                                                 21


<210> 20000
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20000
ucaaggaaga uggcauutc                                                    19


<210> 20001
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20001
ucaaggaaga uggcautt                                                     18


<210> 20002
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20002
ucaaggaaga uggcatt                                                      17


<210> 20003
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20003
ucaaggaaga uggca                                                        15


<210> 20004
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20004
ucaaggaaga uggc                                                         14


<210> 20005
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20005
ucaaggaaga ugg                                                          13


<210> 20006
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20006
ucaaggaaga tg                                                           12


<210> 20007
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20007
ucaaggaaga t                                                            11


<210> 20008
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20008
ucaaggaaga                                                              10


<210> 20009
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20009
ucaaggaag                                                                9


<210> 20010
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20010
caaggaagau ggcauuucua g                                                 21


<210> 20011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20011
caaggaagau ggcauuucta                                                   20


<210> 20012
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20012
caaggaagau ggcauuuct                                                    19


<210> 20013
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20013
caaggaagau ggcauutc                                                     18


<210> 20014
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20014
caaggaagau ggcautt                                                      17


<210> 20015
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20015
caaggaagau ggcatt                                                       16


<210> 20016
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20016
caaggaagau ggcat                                                        15


<210> 20017
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20017
caaggaagau ggca                                                         14


<210> 20018
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20018
caaggaagau ggc                                                          13


<210> 20019
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20019
caaggaagau gg                                                           12


<210> 20020
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20020
caaggaagat g                                                            11


<210> 20021
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20021
caaggaagat                                                              10


<210> 20022
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20022
caaggaaga                                                                9


<210> 20023
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20023
caaggaag                                                                 8


<210> 20024
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20024
aaggaagaug gcauuucuag                                                   20


<210> 20025
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20025
aaggaagaug gcauuucta                                                    19


<210> 20026
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20026
aaggaagaug gcauuuct                                                     18


<210> 20027
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20027
aaggaagaug gcauutc                                                      17


<210> 20028
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20028
aaggaagaug gcautt                                                       16


<210> 20029
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20029
aaggaagaug gcatt                                                        15


<210> 20030
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20030
aaggaagaug gcat                                                         14


<210> 20031
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20031
aaggaagaug gca                                                          13


<210> 20032
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20032
aaggaagaug gc                                                           12


<210> 20033
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20033
aaggaagaug g                                                            11


<210> 20034
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20034
aaggaagatg                                                              10


<210> 20035
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20035
aaggaagat                                                                9


<210> 20036
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20036
aaggaaga                                                                 8


<210> 20037
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20037
aggaagaugg cauuucuag                                                    19


<210> 20038
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20038
aggaagaugg cauuucta                                                     18


<210> 20039
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20039
aggaagaugg cauuuct                                                      17


<210> 20040
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20040
aggaagaugg cauutc                                                       16


<210> 20041
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20041
aggaagaugg cautt                                                        15


<210> 20042
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20042
aggaagaugg catt                                                         14


<210> 20043
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20043
aggaagaugg cat                                                          13


<210> 20044
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20044
aggaagaugg ca                                                           12


<210> 20045
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20045
aggaagaugg                                                              10


<210> 20046
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20046
aggaagatg                                                                9


<210> 20047
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20047
aggaagat                                                                 8


<210> 20048
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20048
ggaagauggc auuucuag                                                     18


<210> 20049
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20049
ggaagauggc auuucta                                                      17


<210> 20050
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20050
ggaagauggc auuuct                                                       16


<210> 20051
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20051
ggaagauggc auutc                                                        15


<210> 20052
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20052
ggaagauggc autt                                                         14


<210> 20053
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20053
ggaagauggc att                                                          13


<210> 20054
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20054
ggaagauggc at                                                           12


<210> 20055
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20055
ggaagauggc a                                                            11


<210> 20056
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20056
ggaagauggc                                                              10


<210> 20057
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20057
ggaagatg                                                                 8


<210> 20058
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20058
gaagauggca uuucuag                                                      17


<210> 20059
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20059
gaagauggca uuucta                                                       16


<210> 20060
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20060
gaagauggca uutc                                                         14


<210> 20061
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20061
gaagauggca utt                                                          13


<210> 20062
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20062
gaagauggca tt                                                           12


<210> 20063
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20063
gaagauggca t                                                            11


<210> 20064
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20064
gaagauggca                                                              10


<210> 20065
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20065
gaagauggc                                                                9


<210> 20066
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20066
gaagaugg                                                                 8


<210> 20067
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20067
aagauggcau uucuag                                                       16


<210> 20068
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20068
aagauggcau uucta                                                        15


<210> 20069
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20069
aagauggcau uuct                                                         14


<210> 20070
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20070
aagauggcau utc                                                          13


<210> 20071
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20071
aagauggcau tt                                                           12


<210> 20072
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20072
aagauggcat t                                                            11


<210> 20073
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20073
aagauggcat                                                              10


<210> 20074
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20074
aagauggca                                                                9


<210> 20075
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20075
aagauggc                                                                 8


<210> 20076
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20076
agauggcauu ucuag                                                        15


<210> 20077
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20077
agauggcauu ucta                                                         14


<210> 20078
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20078
agauggcauu uct                                                          13


<210> 20079
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20079
agauggcauu tc                                                           12


<210> 20080
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20080
agauggcaut t                                                            11


<210> 20081
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20081
agauggcatt                                                              10


<210> 20082
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20082
agauggcat                                                                9


<210> 20083
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20083
agauggca                                                                 8


<210> 20084
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20084
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 20085
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20085
cuccaacauc aaggaagaug gcauuucta                                         29


<210> 20086
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20086
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 20087
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20087
cuccaacauc aaggaagaug gcauutc                                           27


<210> 20088
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20088
cuccaacauc aaggaagaug gcautt                                            26


<210> 20089
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20089
cuccaacauc aaggaagaug gcatt                                             25


<210> 20090
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20090
cuccaacauc aaggaagaug gcat                                              24


<210> 20091
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20091
cuccaacauc aaggaagaug gca                                               23


<210> 20092
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20092
cuccaacauc aaggaagaug gc                                                22


<210> 20093
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20093
cuccaacauc aaggaagaug g                                                 21


<210> 20094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20094
cuccaacauc aaggaagatg                                                   20


<210> 20095
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20095
cuccaacauc aaggaagat                                                    19


<210> 20096
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20096
cuccaacauc aaggaaga                                                     18


<210> 20097
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20097
cuccaacauc aaggaag                                                      17


<210> 20098
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20098
uccaacauca aggaagaugg cauuucuag                                         29


<210> 20099
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20099
uccaacauca aggaagaugg cauuucta                                          28


<210> 20100
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20100
uccaacauca aggaagaugg cauuuct                                           27


<210> 20101
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20101
uccaacauca aggaagaugg cauutc                                            26


<210> 20102
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20102
uccaacauca aggaagaugg cautt                                             25


<210> 20103
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20103
uccaacauca aggaagaugg catt                                              24


<210> 20104
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20104
uccaacauca aggaagaugg cat                                               23


<210> 20105
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20105
uccaacauca aggaagaugg ca                                                22


<210> 20106
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20106
uccaacauca aggaagaugg c                                                 21


<210> 20107
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20107
uccaacauca aggaagaugg                                                   20


<210> 20108
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20108
uccaacauca aggaagatg                                                    19


<210> 20109
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20109
uccaacauca aggaagat                                                     18


<210> 20110
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20110
uccaacauca aggaaga                                                      17


<210> 20111
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20111
uccaacauca aggaag                                                       16


<210> 20112
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20112
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 20113
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20113
ccaacaucaa ggaagauggc auuucta                                           27


<210> 20114
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20114
ccaacaucaa ggaagauggc auuuct                                            26


<210> 20115
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20115
ccaacaucaa ggaagauggc auutc                                             25


<210> 20116
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20116
ccaacaucaa ggaagauggc autt                                              24


<210> 20117
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20117
ccaacaucaa ggaagauggc att                                               23


<210> 20118
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20118
ccaacaucaa ggaagauggc at                                                22


<210> 20119
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20119
ccaacaucaa ggaagauggc a                                                 21


<210> 20120
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20120
ccaacaucaa ggaagauggc                                                   20


<210> 20121
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20121
ccaacaucaa ggaagaugg                                                    19


<210> 20122
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20122
ccaacaucaa ggaagatg                                                     18


<210> 20123
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20123
ccaacaucaa ggaagat                                                      17


<210> 20124
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20124
ccaacaucaa ggaaga                                                       16


<210> 20125
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20125
ccaacaucaa ggaag                                                        15


<210> 20126
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20126
caacaucaag gaagauggca uuucuag                                           27


<210> 20127
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20127
caacaucaag gaagauggca uuucta                                            26


<210> 20128
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20128
caacaucaag gaagauggca uuuct                                             25


<210> 20129
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20129
caacaucaag gaagauggca uutc                                              24


<210> 20130
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20130
caacaucaag gaagauggca utt                                               23


<210> 20131
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20131
caacaucaag gaagauggca tt                                                22


<210> 20132
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20132
caacaucaag gaagauggca t                                                 21


<210> 20133
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20133
caacaucaag gaagauggca                                                   20


<210> 20134
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20134
caacaucaag gaagauggc                                                    19


<210> 20135
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20135
caacaucaag gaagaugg                                                     18


<210> 20136
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20136
caacaucaag gaagatg                                                      17


<210> 20137
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20137
caacaucaag gaagat                                                       16


<210> 20138
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20138
caacaucaag gaaga                                                        15


<210> 20139
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20139
caacaucaag gaag                                                         14


<210> 20140
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20140
aacaucaagg aagauggcau uucuag                                            26


<210> 20141
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20141
aacaucaagg aagauggcau uucta                                             25


<210> 20142
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20142
aacaucaagg aagauggcau uuct                                              24


<210> 20143
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20143
aacaucaagg aagauggcau utc                                               23


<210> 20144
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20144
aacaucaagg aagauggcau tt                                                22


<210> 20145
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20145
aacaucaagg aagauggcat t                                                 21


<210> 20146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20146
aacaucaagg aagauggcat                                                   20


<210> 20147
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20147
aacaucaagg aagauggca                                                    19


<210> 20148
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20148
aacaucaagg aagauggc                                                     18


<210> 20149
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20149
aacaucaagg aagaugg                                                      17


<210> 20150
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20150
aacaucaagg aagatg                                                       16


<210> 20151
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20151
aacaucaagg aagat                                                        15


<210> 20152
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20152
aacaucaagg aaga                                                         14


<210> 20153
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20153
aacaucaagg aag                                                          13


<210> 20154
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20154
acaucaagga agauggcauu ucuag                                             25


<210> 20155
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20155
acaucaagga agauggcauu ucta                                              24


<210> 20156
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20156
acaucaagga agauggcauu uct                                               23


<210> 20157
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20157
acaucaagga agauggcauu tc                                                22


<210> 20158
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20158
acaucaagga agauggcaut t                                                 21


<210> 20159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20159
acaucaagga agauggcatt                                                   20


<210> 20160
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20160
acaucaagga agauggcat                                                    19


<210> 20161
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20161
acaucaagga agauggca                                                     18


<210> 20162
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20162
acaucaagga agauggc                                                      17


<210> 20163
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20163
acaucaagga agaugg                                                       16


<210> 20164
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20164
acaucaagga agatg                                                        15


<210> 20165
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20165
acaucaagga agat                                                         14


<210> 20166
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20166
acaucaagga aga                                                          13


<210> 20167
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20167
acaucaagga ag                                                           12


<210> 20168
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20168
caucaaggaa gauggcauuu cuag                                              24


<210> 20169
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20169
caucaaggaa gauggcauuu cta                                               23


<210> 20170
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20170
caucaaggaa gauggcauuu ct                                                22


<210> 20171
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20171
caucaaggaa gauggcauut c                                                 21


<210> 20172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20172
caucaaggaa gauggcautt                                                   20


<210> 20173
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20173
caucaaggaa gauggcatt                                                    19


<210> 20174
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20174
caucaaggaa gauggcat                                                     18


<210> 20175
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20175
caucaaggaa gauggca                                                      17


<210> 20176
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20176
caucaaggaa gauggc                                                       16


<210> 20177
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20177
caucaaggaa gaugg                                                        15


<210> 20178
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20178
caucaaggaa gatg                                                         14


<210> 20179
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20179
caucaaggaa gat                                                          13


<210> 20180
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20180
caucaaggaa ga                                                           12


<210> 20181
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20181
caucaaggaa g                                                            11


<210> 20182
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20182
aucaaggaag auggcauuuc uag                                               23


<210> 20183
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20183
aucaaggaag auggcauuuc ta                                                22


<210> 20184
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20184
aucaaggaag auggcauuuc t                                                 21


<210> 20185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20185
aucaaggaag auggcauutc                                                   20


<210> 20186
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20186
aucaaggaag auggcautt                                                    19


<210> 20187
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20187
aucaaggaag auggcatt                                                     18


<210> 20188
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20188
aucaaggaag auggcat                                                      17


<210> 20189
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20189
aucaaggaag auggca                                                       16


<210> 20190
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20190
aucaaggaag auggc                                                        15


<210> 20191
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20191
aucaaggaag augg                                                         14


<210> 20192
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20192
aucaaggaag atg                                                          13


<210> 20193
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20193
aucaaggaag at                                                           12


<210> 20194
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20194
aucaaggaag a                                                            11


<210> 20195
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20195
aucaaggaag                                                              10


<210> 20196
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20196
ccagagcagg uaccuccaac atc                                               23


<210> 20197
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20197
ccagagcagg uaccucca                                                     18


<210> 20198
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20198
ccucugugau uuuauaacuu gat                                               23


<210> 20199
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20199
ucacccacca ucaccct                                                      17


<210> 20200
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20200
ugauauccuc aaggucaccc                                                   20


<210> 20201
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20201
cugcuugaug aucaucucgu tg                                                22


<210> 20202
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20202
cugcuugaug aucauctc                                                     18


<210> 20203
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20203
guuuccuuag uaaccacag                                                    19


<210> 20204
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20204
guuuccuuag uaaccac                                                      17


<210> 20205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20205
ucaaggaaga uggcauuuct                                                   20


<210> 20206
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20206
ucaaggaaga uggcauuucu ag                                                22


<210> 20207
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20207
gguaaguucu guccaagc                                                     18


<210> 20208
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20208
guaaguucug uccaagcc                                                     18


<210> 20209
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20209
agucgguaag uucugucc                                                     18


<210> 20210
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20210
cuguccaagc ccgguuga                                                     18


<210> 20211
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20211
uaaguucugu ccaag                                                        15


<210> 20212
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20212
uucuguccaa gcccgguuga                                                   20


<210> 20213
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20213
uucuguccaa gcccggutg                                                    19


<210> 20214
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20214
uucuguccaa gcccggtt                                                     18


<210> 20215
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20215
uucuguccaa gcccggt                                                      17


<210> 20216
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20216
uucuguccaa gcccgg                                                       16


<210> 20217
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20217
uucuguccaa gcccg                                                        15


<210> 20218
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20218
uucuguccaa gccc                                                         14


<210> 20219
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20219
uucuguccaa gcc                                                          13


<210> 20220
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20220
uucuguccaa gc                                                           12


<210> 20221
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20221
uucuguccaa g                                                            11


<210> 20222
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20222
uucuguccaa                                                              10


<210> 20223
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20223
uucugucca                                                                9


<210> 20224
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20224
uucugucc                                                                 8


<210> 20225
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20225
ucuguccaag cccgguuga                                                    19


<210> 20226
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20226
ucuguccaag cccggutg                                                     18


<210> 20227
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20227
ucuguccaag cccggtt                                                      17


<210> 20228
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20228
ucuguccaag cccggt                                                       16


<210> 20229
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20229
ucuguccaag cccgg                                                        15


<210> 20230
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20230
ucuguccaag cccg                                                         14


<210> 20231
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20231
ucuguccaag ccc                                                          13


<210> 20232
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20232
ucuguccaag cc                                                           12


<210> 20233
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20233
ucuguccaag c                                                            11


<210> 20234
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20234
ucuguccaag                                                              10


<210> 20235
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20235
ucuguccaa                                                                9


<210> 20236
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20236
ucugucca                                                                 8


<210> 20237
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20237
cuguccaagc ccggutg                                                      17


<210> 20238
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20238
cuguccaagc ccggtt                                                       16


<210> 20239
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20239
cuguccaagc ccggt                                                        15


<210> 20240
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20240
cuguccaagc ccgg                                                         14


<210> 20241
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20241
cuguccaagc ccg                                                          13


<210> 20242
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20242
cuguccaagc cc                                                           12


<210> 20243
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20243
cuguccaagc c                                                            11


<210> 20244
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20244
cuguccaagc                                                              10


<210> 20245
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20245
cuguccaag                                                                9


<210> 20246
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20246
cuguccaa                                                                 8


<210> 20247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20247
guucugucca agcccggutg                                                   20


<210> 20248
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20248
guucugucca agcccggtt                                                    19


<210> 20249
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20249
guucugucca agcccggt                                                     18


<210> 20250
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20250
guucugucca agcccgg                                                      17


<210> 20251
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20251
guucugucca agcccg                                                       16


<210> 20252
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20252
guucugucca agccc                                                        15


<210> 20253
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20253
guucugucca agcc                                                         14


<210> 20254
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20254
guucugucca agc                                                          13


<210> 20255
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20255
guucugucca ag                                                           12


<210> 20256
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20256
guucugucca a                                                            11


<210> 20257
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20257
guucugucca                                                              10


<210> 20258
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20258
guucugucc                                                                9


<210> 20259
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20259
guucugtc                                                                 8


<210> 20260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20260
aguucugucc aagcccggtt                                                   20


<210> 20261
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20261
aguucugucc aagcccggt                                                    19


<210> 20262
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20262
aguucugucc aagcccgg                                                     18


<210> 20263
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20263
aguucugucc aagcccg                                                      17


<210> 20264
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20264
aguucugucc aagccc                                                       16


<210> 20265
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20265
aguucugucc aagcc                                                        15


<210> 20266
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20266
aguucugucc aagc                                                         14


<210> 20267
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20267
aguucugucc aag                                                          13


<210> 20268
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20268
aguucugucc aa                                                           12


<210> 20269
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20269
aguucugucc a                                                            11


<210> 20270
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20270
aguucugucc                                                              10


<210> 20271
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20271
aguucugtc                                                                9


<210> 20272
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20272
aguucugt                                                                 8


<210> 20273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20273
aaguucuguc caagcccggt                                                   20


<210> 20274
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20274
aaguucuguc caagcccgg                                                    19


<210> 20275
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20275
aaguucuguc caagcccg                                                     18


<210> 20276
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20276
aaguucuguc caagccc                                                      17


<210> 20277
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20277
aaguucuguc caagcc                                                       16


<210> 20278
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20278
aaguucuguc caagc                                                        15


<210> 20279
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20279
aaguucuguc caag                                                         14


<210> 20280
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20280
aaguucuguc caa                                                          13


<210> 20281
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20281
aaguucuguc ca                                                           12


<210> 20282
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20282
aaguucuguc c                                                            11


<210> 20283
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20283
aaguucugtc                                                              10


<210> 20284
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20284
aaguucugt                                                                9


<210> 20285
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20285
aaguuctg                                                                 8


<210> 20286
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20286
uaaguucugu ccaagcccgg                                                   20


<210> 20287
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20287
uaaguucugu ccaagcccg                                                    19


<210> 20288
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20288
uaaguucugu ccaagccc                                                     18


<210> 20289
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20289
uaaguucugu ccaagcc                                                      17


<210> 20290
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20290
uaaguucugu ccaagc                                                       16


<210> 20291
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20291
uaaguucugu ccaa                                                         14


<210> 20292
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20292
uaaguucugu cca                                                          13


<210> 20293
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20293
uaaguucugu cc                                                           12


<210> 20294
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20294
uaaguucugt c                                                            11


<210> 20295
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20295
uaaguucugt                                                              10


<210> 20296
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20296
uaaguuctg                                                                9


<210> 20297
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20297
uaaguuct                                                                 8


<210> 20298
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20298
guaaguucug uccaagcccg                                                   20


<210> 20299
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20299
guaaguucug uccaagccc                                                    19


<210> 20300
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20300
guaaguucug uccaagc                                                      17


<210> 20301
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20301
guaaguucug uccaag                                                       16


<210> 20302
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20302
guaaguucug uccaa                                                        15


<210> 20303
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20303
guaaguucug ucca                                                         14


<210> 20304
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20304
guaaguucug ucc                                                          13


<210> 20305
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20305
guaaguucug tc                                                           12


<210> 20306
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20306
guaaguucug t                                                            11


<210> 20307
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20307
guaaguuctg                                                              10


<210> 20308
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20308
guaaguuct                                                                9


<210> 20309
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20309
guaagutc                                                                 8


<210> 20310
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20310
gguaaguucu guccaagccc                                                   20


<210> 20311
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20311
gguaaguucu guccaagcc                                                    19


<210> 20312
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20312
gguaaguucu guccaag                                                      17


<210> 20313
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20313
gguaaguucu guccaa                                                       16


<210> 20314
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20314
gguaaguucu gucca                                                        15


<210> 20315
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20315
gguaaguucu gucc                                                         14


<210> 20316
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20316
gguaaguucu gtc                                                          13


<210> 20317
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20317
gguaaguucu gt                                                           12


<210> 20318
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20318
gguaaguuct g                                                            11


<210> 20319
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20319
gguaaguuct                                                              10


<210> 20320
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20320
gguaagutc                                                                9


<210> 20321
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20321
gguaagtt                                                                 8


<210> 20322
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20322
cgguaaguuc uguccaagcc                                                   20


<210> 20323
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20323
cgguaaguuc uguccaagc                                                    19


<210> 20324
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20324
cgguaaguuc uguccaag                                                     18


<210> 20325
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20325
cgguaaguuc uguccaa                                                      17


<210> 20326
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20326
cgguaaguuc ugucca                                                       16


<210> 20327
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20327
cgguaaguuc ugucc                                                        15


<210> 20328
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20328
cgguaaguuc ugtc                                                         14


<210> 20329
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20329
cgguaaguuc ugt                                                          13


<210> 20330
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20330
cgguaaguuc tg                                                           12


<210> 20331
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20331
cgguaaguuc t                                                            11


<210> 20332
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20332
cgguaagutc                                                              10


<210> 20333
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20333
cgguaagtt                                                                9


<210> 20334
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20334
cgguaagt                                                                 8


<210> 20335
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20335
ucgguaaguu cuguccaagc                                                   20


<210> 20336
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20336
ucgguaaguu cuguccaag                                                    19


<210> 20337
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20337
ucgguaaguu cuguccaa                                                     18


<210> 20338
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20338
ucgguaaguu cugucca                                                      17


<210> 20339
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20339
ucgguaaguu cugucc                                                       16


<210> 20340
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20340
ucgguaaguu cugtc                                                        15


<210> 20341
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20341
ucgguaaguu cugt                                                         14


<210> 20342
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20342
ucgguaaguu ctg                                                          13


<210> 20343
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20343
ucgguaaguu ct                                                           12


<210> 20344
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20344
ucgguaagut c                                                            11


<210> 20345
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20345
ucgguaagtt                                                              10


<210> 20346
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20346
ucgguaagt                                                                9


<210> 20347
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20347
gucgguaagu ucuguccaag                                                   20


<210> 20348
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20348
gucgguaagu ucuguccaa                                                    19


<210> 20349
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20349
gucgguaagu ucugucca                                                     18


<210> 20350
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20350
gucgguaagu ucugucc                                                      17


<210> 20351
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20351
gucgguaagu ucugtc                                                       16


<210> 20352
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20352
gucgguaagu ucugt                                                        15


<210> 20353
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20353
gucgguaagu uctg                                                         14


<210> 20354
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20354
gucgguaagu uct                                                          13


<210> 20355
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20355
gucgguaagu tc                                                           12


<210> 20356
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20356
gucgguaagt t                                                            11


<210> 20357
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20357
gucgguaagt                                                              10


<210> 20358
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20358
agucgguaag uucuguccaa                                                   20


<210> 20359
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20359
agucgguaag uucugucca                                                    19


<210> 20360
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20360
agucgguaag uucugtc                                                      17


<210> 20361
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20361
agucgguaag uucugt                                                       16


<210> 20362
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20362
agucgguaag uuctg                                                        15


<210> 20363
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20363
agucgguaag uuct                                                         14


<210> 20364
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20364
agucgguaag utc                                                          13


<210> 20365
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20365
agucgguaag tt                                                           12


<210> 20366
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20366
agucgguaag t                                                            11


<210> 20367
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20367
cagucgguaa guucugucca                                                   20


<210> 20368
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20368
cagucgguaa guucugucc                                                    19


<210> 20369
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20369
cagucgguaa guucugtc                                                     18


<210> 20370
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20370
cagucgguaa guucugt                                                      17


<210> 20371
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20371
cagucgguaa guuctg                                                       16


<210> 20372
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20372
cagucgguaa guuct                                                        15


<210> 20373
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20373
cagucgguaa gutc                                                         14


<210> 20374
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20374
cagucgguaa gtt                                                          13


<210> 20375
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20375
cagucgguaa gt                                                           12


<210> 20376
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20376
ccagucggua aguucugucc                                                   20


<210> 20377
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20377
ccagucggua aguucugtc                                                    19


<210> 20378
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20378
ccagucggua aguucugt                                                     18


<210> 20379
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20379
ccagucggua aguuctg                                                      17


<210> 20380
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20380
ccagucggua aguuct                                                       16


<210> 20381
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20381
ccagucggua agutc                                                        15


<210> 20382
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20382
ccagucggua agtt                                                         14


<210> 20383
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20383
ccagucggua agt                                                          13


<210> 20384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20384
gccagucggu aaguucugtc                                                   20


<210> 20385
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20385
gccagucggu aaguucugt                                                    19


<210> 20386
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20386
gccagucggu aaguuctg                                                     18


<210> 20387
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20387
gccagucggu aaguuct                                                      17


<210> 20388
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20388
gccagucggu aagutc                                                       16


<210> 20389
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20389
gccagucggu aagtt                                                        15


<210> 20390
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20390
gccagucggu aagt                                                         14


<210> 20391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20391
ucaaggaaga uggcauuuct                                                   20


<210> 20392
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20392
ucaaggaaga uggcauuucu ag                                                22


<210> 20393
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20393
ucaaggaaga uggcat                                                       16


<210> 20394
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20394
gaagauggca uuuct                                                        15


<210> 20395
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20395
ucaaggaaga uggcauuuct a                                                 21


<210> 20396
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20396
ucaaggaaga uggcauutc                                                    19


<210> 20397
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20397
ucaaggaaga uggcautt                                                     18


<210> 20398
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20398
ucaaggaaga uggcatt                                                      17


<210> 20399
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20399
ucaaggaaga uggca                                                        15


<210> 20400
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20400
ucaaggaaga uggc                                                         14


<210> 20401
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20401
ucaaggaaga ugg                                                          13


<210> 20402
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20402
ucaaggaaga tg                                                           12


<210> 20403
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20403
ucaaggaaga t                                                            11


<210> 20404
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20404
ucaaggaaga                                                              10


<210> 20405
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20405
ucaaggaag                                                                9


<210> 20406
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20406
caaggaagau ggcauuucua g                                                 21


<210> 20407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20407
caaggaagau ggcauuucta                                                   20


<210> 20408
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20408
caaggaagau ggcauuuct                                                    19


<210> 20409
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20409
caaggaagau ggcauutc                                                     18


<210> 20410
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20410
caaggaagau ggcautt                                                      17


<210> 20411
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20411
caaggaagau ggcatt                                                       16


<210> 20412
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20412
caaggaagau ggcat                                                        15


<210> 20413
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20413
caaggaagau ggca                                                         14


<210> 20414
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20414
caaggaagau ggc                                                          13


<210> 20415
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20415
caaggaagau gg                                                           12


<210> 20416
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20416
caaggaagat g                                                            11


<210> 20417
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20417
caaggaagat                                                              10


<210> 20418
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20418
caaggaaga                                                                9


<210> 20419
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20419
caaggaag                                                                 8


<210> 20420
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20420
aaggaagaug gcauuucuag                                                   20


<210> 20421
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20421
aaggaagaug gcauuucta                                                    19


<210> 20422
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20422
aaggaagaug gcauuuct                                                     18


<210> 20423
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20423
aaggaagaug gcauutc                                                      17


<210> 20424
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20424
aaggaagaug gcautt                                                       16


<210> 20425
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20425
aaggaagaug gcatt                                                        15


<210> 20426
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20426
aaggaagaug gcat                                                         14


<210> 20427
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20427
aaggaagaug gca                                                          13


<210> 20428
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20428
aaggaagaug gc                                                           12


<210> 20429
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20429
aaggaagaug g                                                            11


<210> 20430
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20430
aaggaagatg                                                              10


<210> 20431
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20431
aaggaagat                                                                9


<210> 20432
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20432
aaggaaga                                                                 8


<210> 20433
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20433
aggaagaugg cauuucuag                                                    19


<210> 20434
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20434
aggaagaugg cauuucta                                                     18


<210> 20435
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20435
aggaagaugg cauuuct                                                      17


<210> 20436
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20436
aggaagaugg cauutc                                                       16


<210> 20437
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20437
aggaagaugg cautt                                                        15


<210> 20438
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20438
aggaagaugg catt                                                         14


<210> 20439
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20439
aggaagaugg cat                                                          13


<210> 20440
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20440
aggaagaugg ca                                                           12


<210> 20441
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20441
aggaagaugg                                                              10


<210> 20442
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20442
aggaagatg                                                                9


<210> 20443
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20443
aggaagat                                                                 8


<210> 20444
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20444
ggaagauggc auuucuag                                                     18


<210> 20445
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20445
ggaagauggc auuucta                                                      17


<210> 20446
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20446
ggaagauggc auuuct                                                       16


<210> 20447
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20447
ggaagauggc auutc                                                        15


<210> 20448
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20448
ggaagauggc autt                                                         14


<210> 20449
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20449
ggaagauggc att                                                          13


<210> 20450
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20450
ggaagauggc at                                                           12


<210> 20451
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20451
ggaagauggc a                                                            11


<210> 20452
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20452
ggaagauggc                                                              10


<210> 20453
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20453
ggaagatg                                                                 8


<210> 20454
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20454
gaagauggca uuucuag                                                      17


<210> 20455
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20455
gaagauggca uuucta                                                       16


<210> 20456
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20456
gaagauggca uutc                                                         14


<210> 20457
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20457
gaagauggca utt                                                          13


<210> 20458
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20458
gaagauggca tt                                                           12


<210> 20459
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20459
gaagauggca t                                                            11


<210> 20460
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20460
gaagauggca                                                              10


<210> 20461
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20461
gaagauggc                                                                9


<210> 20462
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20462
gaagaugg                                                                 8


<210> 20463
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20463
aagauggcau uucuag                                                       16


<210> 20464
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20464
aagauggcau uucta                                                        15


<210> 20465
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20465
aagauggcau uuct                                                         14


<210> 20466
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20466
aagauggcau utc                                                          13


<210> 20467
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20467
aagauggcau tt                                                           12


<210> 20468
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20468
aagauggcat t                                                            11


<210> 20469
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20469
aagauggcat                                                              10


<210> 20470
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20470
aagauggca                                                                9


<210> 20471
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20471
aagauggc                                                                 8


<210> 20472
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20472
agauggcauu ucuag                                                        15


<210> 20473
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20473
agauggcauu ucta                                                         14


<210> 20474
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20474
agauggcauu uct                                                          13


<210> 20475
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20475
agauggcauu tc                                                           12


<210> 20476
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20476
agauggcaut t                                                            11


<210> 20477
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20477
agauggcatt                                                              10


<210> 20478
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20478
agauggcat                                                                9


<210> 20479
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20479
agauggca                                                                 8


<210> 20480
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20480
cuccaacauc aaggaagaug gcauuucuag                                        30


<210> 20481
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20481
cuccaacauc aaggaagaug gcauuucta                                         29


<210> 20482
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20482
cuccaacauc aaggaagaug gcauuuct                                          28


<210> 20483
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20483
cuccaacauc aaggaagaug gcauutc                                           27


<210> 20484
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20484
cuccaacauc aaggaagaug gcautt                                            26


<210> 20485
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20485
cuccaacauc aaggaagaug gcatt                                             25


<210> 20486
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20486
cuccaacauc aaggaagaug gcat                                              24


<210> 20487
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20487
cuccaacauc aaggaagaug gca                                               23


<210> 20488
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20488
cuccaacauc aaggaagaug gc                                                22


<210> 20489
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20489
cuccaacauc aaggaagaug g                                                 21


<210> 20490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20490
cuccaacauc aaggaagatg                                                   20


<210> 20491
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20491
cuccaacauc aaggaagat                                                    19


<210> 20492
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20492
cuccaacauc aaggaaga                                                     18


<210> 20493
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20493
cuccaacauc aaggaag                                                      17


<210> 20494
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20494
uccaacauca aggaagaugg cauuucuag                                         29


<210> 20495
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20495
uccaacauca aggaagaugg cauuucta                                          28


<210> 20496
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20496
uccaacauca aggaagaugg cauuuct                                           27


<210> 20497
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20497
uccaacauca aggaagaugg cauutc                                            26


<210> 20498
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20498
uccaacauca aggaagaugg cautt                                             25


<210> 20499
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20499
uccaacauca aggaagaugg catt                                              24


<210> 20500
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20500
uccaacauca aggaagaugg cat                                               23


<210> 20501
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20501
uccaacauca aggaagaugg ca                                                22


<210> 20502
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20502
uccaacauca aggaagaugg c                                                 21


<210> 20503
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20503
uccaacauca aggaagaugg                                                   20


<210> 20504
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20504
uccaacauca aggaagatg                                                    19


<210> 20505
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20505
uccaacauca aggaagat                                                     18


<210> 20506
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20506
uccaacauca aggaaga                                                      17


<210> 20507
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20507
uccaacauca aggaag                                                       16


<210> 20508
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20508
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 20509
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20509
ccaacaucaa ggaagauggc auuucta                                           27


<210> 20510
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20510
ccaacaucaa ggaagauggc auuuct                                            26


<210> 20511
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20511
ccaacaucaa ggaagauggc auutc                                             25


<210> 20512
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20512
ccaacaucaa ggaagauggc autt                                              24


<210> 20513
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20513
ccaacaucaa ggaagauggc att                                               23


<210> 20514
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20514
ccaacaucaa ggaagauggc at                                                22


<210> 20515
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20515
ccaacaucaa ggaagauggc a                                                 21


<210> 20516
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20516
ccaacaucaa ggaagauggc                                                   20


<210> 20517
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20517
ccaacaucaa ggaagaugg                                                    19


<210> 20518
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20518
ccaacaucaa ggaagatg                                                     18


<210> 20519
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20519
ccaacaucaa ggaagat                                                      17


<210> 20520
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20520
ccaacaucaa ggaaga                                                       16


<210> 20521
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20521
ccaacaucaa ggaag                                                        15


<210> 20522
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20522
caacaucaag gaagauggca uuucuag                                           27


<210> 20523
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20523
caacaucaag gaagauggca uuucta                                            26


<210> 20524
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20524
caacaucaag gaagauggca uuuct                                             25


<210> 20525
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20525
caacaucaag gaagauggca uutc                                              24


<210> 20526
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20526
caacaucaag gaagauggca utt                                               23


<210> 20527
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20527
caacaucaag gaagauggca tt                                                22


<210> 20528
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20528
caacaucaag gaagauggca t                                                 21


<210> 20529
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20529
caacaucaag gaagauggca                                                   20


<210> 20530
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20530
caacaucaag gaagauggc                                                    19


<210> 20531
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20531
caacaucaag gaagaugg                                                     18


<210> 20532
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20532
caacaucaag gaagatg                                                      17


<210> 20533
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20533
caacaucaag gaagat                                                       16


<210> 20534
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20534
caacaucaag gaaga                                                        15


<210> 20535
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20535
caacaucaag gaag                                                         14


<210> 20536
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20536
aacaucaagg aagauggcau uucuag                                            26


<210> 20537
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20537
aacaucaagg aagauggcau uucta                                             25


<210> 20538
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20538
aacaucaagg aagauggcau uuct                                              24


<210> 20539
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20539
aacaucaagg aagauggcau utc                                               23


<210> 20540
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20540
aacaucaagg aagauggcau tt                                                22


<210> 20541
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20541
aacaucaagg aagauggcat t                                                 21


<210> 20542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20542
aacaucaagg aagauggcat                                                   20


<210> 20543
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20543
aacaucaagg aagauggca                                                    19


<210> 20544
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20544
aacaucaagg aagauggc                                                     18


<210> 20545
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20545
aacaucaagg aagaugg                                                      17


<210> 20546
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20546
aacaucaagg aagatg                                                       16


<210> 20547
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20547
aacaucaagg aagat                                                        15


<210> 20548
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20548
aacaucaagg aaga                                                         14


<210> 20549
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20549
aacaucaagg aag                                                          13


<210> 20550
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20550
acaucaagga agauggcauu ucuag                                             25


<210> 20551
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20551
acaucaagga agauggcauu ucta                                              24


<210> 20552
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20552
acaucaagga agauggcauu uct                                               23


<210> 20553
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20553
acaucaagga agauggcauu tc                                                22


<210> 20554
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20554
acaucaagga agauggcaut t                                                 21


<210> 20555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20555
acaucaagga agauggcatt                                                   20


<210> 20556
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20556
acaucaagga agauggcat                                                    19


<210> 20557
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20557
acaucaagga agauggca                                                     18


<210> 20558
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20558
acaucaagga agauggc                                                      17


<210> 20559
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20559
acaucaagga agaugg                                                       16


<210> 20560
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20560
acaucaagga agatg                                                        15


<210> 20561
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20561
acaucaagga agat                                                         14


<210> 20562
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20562
acaucaagga aga                                                          13


<210> 20563
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20563
acaucaagga ag                                                           12


<210> 20564
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20564
caucaaggaa gauggcauuu cuag                                              24


<210> 20565
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20565
caucaaggaa gauggcauuu cta                                               23


<210> 20566
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20566
caucaaggaa gauggcauuu ct                                                22


<210> 20567
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20567
caucaaggaa gauggcauut c                                                 21


<210> 20568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20568
caucaaggaa gauggcautt                                                   20


<210> 20569
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20569
caucaaggaa gauggcatt                                                    19


<210> 20570
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20570
caucaaggaa gauggcat                                                     18


<210> 20571
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20571
caucaaggaa gauggca                                                      17


<210> 20572
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20572
caucaaggaa gauggc                                                       16


<210> 20573
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20573
caucaaggaa gaugg                                                        15


<210> 20574
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20574
caucaaggaa gatg                                                         14


<210> 20575
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20575
caucaaggaa gat                                                          13


<210> 20576
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20576
caucaaggaa ga                                                           12


<210> 20577
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20577
caucaaggaa g                                                            11


<210> 20578
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20578
aucaaggaag auggcauuuc uag                                               23


<210> 20579
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20579
aucaaggaag auggcauuuc ta                                                22


<210> 20580
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20580
aucaaggaag auggcauuuc t                                                 21


<210> 20581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20581
aucaaggaag auggcauutc                                                   20


<210> 20582
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20582
aucaaggaag auggcautt                                                    19


<210> 20583
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20583
aucaaggaag auggcatt                                                     18


<210> 20584
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20584
aucaaggaag auggcat                                                      17


<210> 20585
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20585
aucaaggaag auggca                                                       16


<210> 20586
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20586
aucaaggaag auggc                                                        15


<210> 20587
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20587
aucaaggaag augg                                                         14


<210> 20588
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20588
aucaaggaag atg                                                          13


<210> 20589
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20589
aucaaggaag at                                                           12


<210> 20590
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20590
aucaaggaag a                                                            11


<210> 20591
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20591
aucaaggaag                                                              10


<210> 20592
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20592
ccagagcagg uaccuccaac atc                                               23


<210> 20593
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20593
ccagagcagg uaccucca                                                     18


<210> 20594
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20594
ccucugugau uuuauaacuu gat                                               23


<210> 20595
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20595
ucacccacca ucaccct                                                      17


<210> 20596
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20596
ugauauccuc aaggucaccc                                                   20


<210> 20597
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20597
cugcuugaug aucaucucgu tg                                                22


<210> 20598
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20598
cugcuugaug aucauctc                                                     18


<210> 20599
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20599
guuuccuuag uaaccacag                                                    19


<210> 20600
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 20600
guuuccuuag uaaccac                                                      17


<210> 20601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20601
tcaaggaaga uggcauuuct                                                   20


<210> 20602
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 20602
tcaaggaaga uggcauuucu ag                                                22


<210> 20603
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 20603
gguaaguucu guccaagc                                                     18


<210> 20604
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 20604
gtaaguucug uccaagcc                                                     18


<210> 20605
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 20605
agucgguaag uucugucc                                                     18


<210> 20606
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20606
ctguccaagc ccgguuga                                                     18


<210> 20607
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20607
taaguucugu ccaag                                                        15


<210> 20608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20608
ttcuguccaa gcccgguuga                                                   20


<210> 20609
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20609
ttcuguccaa gcccggutg                                                    19


<210> 20610
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20610
ttcuguccaa gcccggtt                                                     18


<210> 20611
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20611
ttcuguccaa gcccggt                                                      17


<210> 20612
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20612
ttcuguccaa gcccgg                                                       16


<210> 20613
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20613
ttcuguccaa gcccg                                                        15


<210> 20614
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 20614
ttcuguccaa gccc                                                         14


<210> 20615
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 20615
ttcuguccaa gcc                                                          13


<210> 20616
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 20616
ttcuguccaa gc                                                           12


<210> 20617
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20617
ttcuguccaa g                                                            11


<210> 20618
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20618
ttcuguccaa                                                              10


<210> 20619
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20619
ttcugucca                                                                9


<210> 20620
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 20620
ttcugucc                                                                 8


<210> 20621
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20621
tcuguccaag cccgguuga                                                    19


<210> 20622
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20622
tcuguccaag cccggutg                                                     18


<210> 20623
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20623
tcuguccaag cccggtt                                                      17


<210> 20624
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20624
tcuguccaag cccggt                                                       16


<210> 20625
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20625
tcuguccaag cccgg                                                        15


<210> 20626
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20626
tcuguccaag cccg                                                         14


<210> 20627
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 20627
tcuguccaag ccc                                                          13


<210> 20628
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 20628
tcuguccaag cc                                                           12


<210> 20629
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 20629
tcuguccaag c                                                            11


<210> 20630
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20630
tcuguccaag                                                              10


<210> 20631
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20631
tcuguccaa                                                                9


<210> 20632
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20632
tcugucca                                                                 8


<210> 20633
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20633
ctguccaagc ccggutg                                                      17


<210> 20634
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20634
ctguccaagc ccggtt                                                       16


<210> 20635
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20635
ctguccaagc ccggt                                                        15


<210> 20636
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20636
ctguccaagc ccgg                                                         14


<210> 20637
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20637
ctguccaagc ccg                                                          13


<210> 20638
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 20638
ctguccaagc cc                                                           12


<210> 20639
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 20639
ctguccaagc c                                                            11


<210> 20640
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 20640
ctguccaagc                                                              10


<210> 20641
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20641
ctguccaag                                                                9


<210> 20642
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20642
ctguccaa                                                                 8


<210> 20643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20643
gtucugucca agcccggutg                                                   20


<210> 20644
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20644
gtucugucca agcccggtt                                                    19


<210> 20645
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20645
gtucugucca agcccggt                                                     18


<210> 20646
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20646
gtucugucca agcccgg                                                      17


<210> 20647
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20647
gtucugucca agcccg                                                       16


<210> 20648
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 20648
gtucugucca agccc                                                        15


<210> 20649
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 20649
gtucugucca agcc                                                         14


<210> 20650
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 20650
gtucugucca agc                                                          13


<210> 20651
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20651
gtucugucca ag                                                           12


<210> 20652
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20652
gtucugucca a                                                            11


<210> 20653
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20653
gtucugucca                                                              10


<210> 20654
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 20654
gtucugucc                                                                9


<210> 20655
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 20655
gtucugtc                                                                 8


<210> 20656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20656
aguucugucc aagcccggtt                                                   20


<210> 20657
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20657
aguucugucc aagcccggt                                                    19


<210> 20658
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20658
aguucugucc aagcccgg                                                     18


<210> 20659
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20659
aguucugucc aagcccg                                                      17


<210> 20660
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 20660
aguucugucc aagccc                                                       16


<210> 20661
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 20661
aguucugucc aagcc                                                        15


<210> 20662
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 20662
aguucugucc aagc                                                         14


<210> 20663
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20663
aguucugucc aag                                                          13


<210> 20664
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20664
aguucugucc aa                                                           12


<210> 20665
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20665
aguucugucc a                                                            11


<210> 20666
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 20666
aguucugucc                                                              10


<210> 20667
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 20667
aguucugtc                                                                9


<210> 20668
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20668
aguucugt                                                                 8


<210> 20669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20669
aaguucuguc caagcccggt                                                   20


<210> 20670
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20670
aaguucuguc caagcccgg                                                    19


<210> 20671
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20671
aaguucuguc caagcccg                                                     18


<210> 20672
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 20672
aaguucuguc caagccc                                                      17


<210> 20673
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 20673
aaguucuguc caagcc                                                       16


<210> 20674
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 20674
aaguucuguc caagc                                                        15


<210> 20675
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20675
aaguucuguc caag                                                         14


<210> 20676
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20676
aaguucuguc caa                                                          13


<210> 20677
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20677
aaguucuguc ca                                                           12


<210> 20678
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 20678
aaguucuguc c                                                            11


<210> 20679
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 20679
aaguucugtc                                                              10


<210> 20680
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20680
aaguucugt                                                                9


<210> 20681
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20681
aaguuctg                                                                 8


<210> 20682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20682
taaguucugu ccaagcccgg                                                   20


<210> 20683
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20683
taaguucugu ccaagcccg                                                    19


<210> 20684
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 20684
taaguucugu ccaagccc                                                     18


<210> 20685
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 20685
taaguucugu ccaagcc                                                      17


<210> 20686
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 20686
taaguucugu ccaagc                                                       16


<210> 20687
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20687
taaguucugu ccaa                                                         14


<210> 20688
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20688
taaguucugu cca                                                          13


<210> 20689
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 20689
taaguucugu cc                                                           12


<210> 20690
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 20690
taaguucugt c                                                            11


<210> 20691
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20691
taaguucugt                                                              10


<210> 20692
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20692
taaguuctg                                                                9


<210> 20693
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20693
taaguuct                                                                 8


<210> 20694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20694
gtaaguucug uccaagcccg                                                   20


<210> 20695
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 20695
gtaaguucug uccaagccc                                                    19


<210> 20696
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 20696
gtaaguucug uccaagc                                                      17


<210> 20697
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20697
gtaaguucug uccaag                                                       16


<210> 20698
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20698
gtaaguucug uccaa                                                        15


<210> 20699
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20699
gtaaguucug ucca                                                         14


<210> 20700
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 20700
gtaaguucug ucc                                                          13


<210> 20701
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 20701
gtaaguucug tc                                                           12


<210> 20702
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20702
gtaaguucug t                                                            11


<210> 20703
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20703
gtaaguuctg                                                              10


<210> 20704
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20704
gtaaguuct                                                                9


<210> 20705
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 20705
gtaagutc                                                                 8


<210> 20706
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 20706
gguaaguucu guccaagccc                                                   20


<210> 20707
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 20707
gguaaguucu guccaagcc                                                    19


<210> 20708
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20708
gguaaguucu guccaag                                                      17


<210> 20709
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20709
gguaaguucu guccaa                                                       16


<210> 20710
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20710
gguaaguucu gucca                                                        15


<210> 20711
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 20711
gguaaguucu gucc                                                         14


<210> 20712
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 20712
gguaaguucu gtc                                                          13


<210> 20713
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20713
gguaaguucu gt                                                           12


<210> 20714
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20714
gguaaguuct g                                                            11


<210> 20715
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20715
gguaaguuct                                                              10


<210> 20716
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 20716
gguaagutc                                                                9


<210> 20717
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20717
gguaagtt                                                                 8


<210> 20718
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 20718
cgguaaguuc uguccaagcc                                                   20


<210> 20719
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 20719
cgguaaguuc uguccaagc                                                    19


<210> 20720
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20720
cgguaaguuc uguccaag                                                     18


<210> 20721
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20721
cgguaaguuc uguccaa                                                      17


<210> 20722
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20722
cgguaaguuc ugucca                                                       16


<210> 20723
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 20723
cgguaaguuc ugucc                                                        15


<210> 20724
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 20724
cgguaaguuc ugtc                                                         14


<210> 20725
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20725
cgguaaguuc ugt                                                          13


<210> 20726
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20726
cgguaaguuc tg                                                           12


<210> 20727
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20727
cgguaaguuc t                                                            11


<210> 20728
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 20728
cgguaagutc                                                              10


<210> 20729
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20729
cgguaagtt                                                                9


<210> 20730
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20730
cgguaagt                                                                 8


<210> 20731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 20731
tcgguaaguu cuguccaagc                                                   20


<210> 20732
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20732
tcgguaaguu cuguccaag                                                    19


<210> 20733
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20733
tcgguaaguu cuguccaa                                                     18


<210> 20734
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20734
tcgguaaguu cugucca                                                      17


<210> 20735
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 20735
tcgguaaguu cugucc                                                       16


<210> 20736
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 20736
tcgguaaguu cugtc                                                        15


<210> 20737
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20737
tcgguaaguu cugt                                                         14


<210> 20738
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20738
tcgguaaguu ctg                                                          13


<210> 20739
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20739
tcgguaaguu ct                                                           12


<210> 20740
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 20740
tcgguaagut c                                                            11


<210> 20741
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20741
tcgguaagtt                                                              10


<210> 20742
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20742
tcgguaagt                                                                9


<210> 20743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20743
gtcgguaagu ucuguccaag                                                   20


<210> 20744
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20744
gtcgguaagu ucuguccaa                                                    19


<210> 20745
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20745
gtcgguaagu ucugucca                                                     18


<210> 20746
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 20746
gtcgguaagu ucugucc                                                      17


<210> 20747
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 20747
gtcgguaagu ucugtc                                                       16


<210> 20748
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20748
gtcgguaagu ucugt                                                        15


<210> 20749
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20749
gtcgguaagu uctg                                                         14


<210> 20750
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20750
gtcgguaagu uct                                                          13


<210> 20751
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 20751
gtcgguaagu tc                                                           12


<210> 20752
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20752
gtcgguaagt t                                                            11


<210> 20753
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20753
gtcgguaagt                                                              10


<210> 20754
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20754
agucgguaag uucuguccaa                                                   20


<210> 20755
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20755
agucgguaag uucugucca                                                    19


<210> 20756
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 20756
agucgguaag uucugtc                                                      17


<210> 20757
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20757
agucgguaag uucugt                                                       16


<210> 20758
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20758
agucgguaag uuctg                                                        15


<210> 20759
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20759
agucgguaag uuct                                                         14


<210> 20760
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 20760
agucgguaag utc                                                          13


<210> 20761
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20761
agucgguaag tt                                                           12


<210> 20762
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20762
agucgguaag t                                                            11


<210> 20763
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20763
cagucgguaa guucugucca                                                   20


<210> 20764
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 20764
cagucgguaa guucugucc                                                    19


<210> 20765
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 20765
cagucgguaa guucugtc                                                     18


<210> 20766
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20766
cagucgguaa guucugt                                                      17


<210> 20767
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20767
cagucgguaa guuctg                                                       16


<210> 20768
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20768
cagucgguaa guuct                                                        15


<210> 20769
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 20769
cagucgguaa gutc                                                         14


<210> 20770
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20770
cagucgguaa gtt                                                          13


<210> 20771
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20771
cagucgguaa gt                                                           12


<210> 20772
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 20772
ccagucggua aguucugucc                                                   20


<210> 20773
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 20773
ccagucggua aguucugtc                                                    19


<210> 20774
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20774
ccagucggua aguucugt                                                     18


<210> 20775
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20775
ccagucggua aguuctg                                                      17


<210> 20776
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20776
ccagucggua aguuct                                                       16


<210> 20777
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 20777
ccagucggua agutc                                                        15


<210> 20778
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20778
ccagucggua agtt                                                         14


<210> 20779
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20779
ccagucggua agt                                                          13


<210> 20780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 20780
gccagucggu aaguucugtc                                                   20


<210> 20781
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20781
gccagucggu aaguucugt                                                    19


<210> 20782
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20782
gccagucggu aaguuctg                                                     18


<210> 20783
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20783
gccagucggu aaguuct                                                      17


<210> 20784
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 20784
gccagucggu aagutc                                                       16


<210> 20785
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20785
gccagucggu aagtt                                                        15


<210> 20786
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20786
gccagucggu aagt                                                         14


<210> 20787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20787
tcaaggaaga uggcauuuct                                                   20


<210> 20788
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 20788
tcaaggaaga uggcauuucu ag                                                22


<210> 20789
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20789
tcaaggaaga uggcat                                                       16


<210> 20790
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20790
gaagauggca uuuct                                                        15


<210> 20791
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 20791
tcaaggaaga uggcauuuct a                                                 21


<210> 20792
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 20792
tcaaggaaga uggcauutc                                                    19


<210> 20793
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20793
tcaaggaaga uggcautt                                                     18


<210> 20794
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20794
tcaaggaaga uggcatt                                                      17


<210> 20795
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20795
tcaaggaaga uggca                                                        15


<210> 20796
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 20796
tcaaggaaga uggc                                                         14


<210> 20797
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20797
tcaaggaaga ugg                                                          13


<210> 20798
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20798
tcaaggaaga tg                                                           12


<210> 20799
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20799
tcaaggaaga t                                                            11


<210> 20800
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20800
tcaaggaaga                                                              10


<210> 20801
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20801
tcaaggaag                                                                9


<210> 20802
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 20802
caaggaagau ggcauuucua g                                                 21


<210> 20803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20803
caaggaagau ggcauuucta                                                   20


<210> 20804
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20804
caaggaagau ggcauuuct                                                    19


<210> 20805
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 20805
caaggaagau ggcauutc                                                     18


<210> 20806
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20806
caaggaagau ggcautt                                                      17


<210> 20807
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20807
caaggaagau ggcatt                                                       16


<210> 20808
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20808
caaggaagau ggcat                                                        15


<210> 20809
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20809
caaggaagau ggca                                                         14


<210> 20810
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 20810
caaggaagau ggc                                                          13


<210> 20811
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20811
caaggaagau gg                                                           12


<210> 20812
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20812
caaggaagat g                                                            11


<210> 20813
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20813
caaggaagat                                                              10


<210> 20814
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20814
caaggaaga                                                                9


<210> 20815
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20815
caaggaag                                                                 8


<210> 20816
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20816
aaggaagaug gcauuucuag                                                   20


<210> 20817
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20817
aaggaagaug gcauuucta                                                    19


<210> 20818
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20818
aaggaagaug gcauuuct                                                     18


<210> 20819
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 20819
aaggaagaug gcauutc                                                      17


<210> 20820
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20820
aaggaagaug gcautt                                                       16


<210> 20821
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20821
aaggaagaug gcatt                                                        15


<210> 20822
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20822
aaggaagaug gcat                                                         14


<210> 20823
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20823
aaggaagaug gca                                                          13


<210> 20824
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 20824
aaggaagaug gc                                                           12


<210> 20825
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20825
aaggaagaug g                                                            11


<210> 20826
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20826
aaggaagatg                                                              10


<210> 20827
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20827
aaggaagat                                                                9


<210> 20828
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20828
aaggaaga                                                                 8


<210> 20829
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20829
aggaagaugg cauuucuag                                                    19


<210> 20830
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20830
aggaagaugg cauuucta                                                     18


<210> 20831
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20831
aggaagaugg cauuuct                                                      17


<210> 20832
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 20832
aggaagaugg cauutc                                                       16


<210> 20833
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20833
aggaagaugg cautt                                                        15


<210> 20834
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20834
aggaagaugg catt                                                         14


<210> 20835
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20835
aggaagaugg cat                                                          13


<210> 20836
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20836
aggaagaugg ca                                                           12


<210> 20837
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20837
aggaagaugg                                                              10


<210> 20838
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20838
aggaagatg                                                                9


<210> 20839
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20839
aggaagat                                                                 8


<210> 20840
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20840
ggaagauggc auuucuag                                                     18


<210> 20841
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20841
ggaagauggc auuucta                                                      17


<210> 20842
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20842
ggaagauggc auuuct                                                       16


<210> 20843
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 20843
ggaagauggc auutc                                                        15


<210> 20844
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20844
ggaagauggc autt                                                         14


<210> 20845
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20845
ggaagauggc att                                                          13


<210> 20846
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20846
ggaagauggc at                                                           12


<210> 20847
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20847
ggaagauggc a                                                            11


<210> 20848
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 20848
ggaagauggc                                                              10


<210> 20849
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20849
ggaagatg                                                                 8


<210> 20850
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20850
gaagauggca uuucuag                                                      17


<210> 20851
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20851
gaagauggca uuucta                                                       16


<210> 20852
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 20852
gaagauggca uutc                                                         14


<210> 20853
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20853
gaagauggca utt                                                          13


<210> 20854
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20854
gaagauggca tt                                                           12


<210> 20855
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20855
gaagauggca t                                                            11


<210> 20856
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20856
gaagauggca                                                              10


<210> 20857
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 20857
gaagauggc                                                                9


<210> 20858
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20858
gaagaugg                                                                 8


<210> 20859
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20859
aagauggcau uucuag                                                       16


<210> 20860
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20860
aagauggcau uucta                                                        15


<210> 20861
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20861
aagauggcau uuct                                                         14


<210> 20862
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 20862
aagauggcau utc                                                          13


<210> 20863
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20863
aagauggcau tt                                                           12


<210> 20864
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20864
aagauggcat t                                                            11


<210> 20865
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20865
aagauggcat                                                              10


<210> 20866
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20866
aagauggca                                                                9


<210> 20867
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 20867
aagauggc                                                                 8


<210> 20868
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20868
agauggcauu ucuag                                                        15


<210> 20869
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20869
agauggcauu ucta                                                         14


<210> 20870
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20870
agauggcauu uct                                                          13


<210> 20871
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 20871
agauggcauu tc                                                           12


<210> 20872
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20872
agauggcaut t                                                            11


<210> 20873
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20873
agauggcatt                                                              10


<210> 20874
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 20874
agauggcat                                                                9


<210> 20875
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 20875
agauggca                                                                 8


<210> 20876
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 20876
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 20877
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 20877
ctccaacauc aaggaagaug gcauuucta                                         29


<210> 20878
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 20878
ctccaacauc aaggaagaug gcauuuct                                          28


<210> 20879
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<400> 20879
ctccaacauc aaggaagaug gcauutc                                           27


<210> 20880
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 20880
ctccaacauc aaggaagaug gcautt                                            26


<210> 20881
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 20881
ctccaacauc aaggaagaug gcatt                                             25


<210> 20882
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 20882
ctccaacauc aaggaagaug gcat                                              24


<210> 20883
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 20883
ctccaacauc aaggaagaug gca                                               23


<210> 20884
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 20884
ctccaacauc aaggaagaug gc                                                22


<210> 20885
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 20885
ctccaacauc aaggaagaug g                                                 21


<210> 20886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20886
ctccaacauc aaggaagatg                                                   20


<210> 20887
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20887
ctccaacauc aaggaagat                                                    19


<210> 20888
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20888
ctccaacauc aaggaaga                                                     18


<210> 20889
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20889
ctccaacauc aaggaag                                                      17


<210> 20890
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 20890
tccaacauca aggaagaugg cauuucuag                                         29


<210> 20891
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 20891
tccaacauca aggaagaugg cauuucta                                          28


<210> 20892
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 20892
tccaacauca aggaagaugg cauuuct                                           27


<210> 20893
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<400> 20893
tccaacauca aggaagaugg cauutc                                            26


<210> 20894
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 20894
tccaacauca aggaagaugg cautt                                             25


<210> 20895
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 20895
tccaacauca aggaagaugg catt                                              24


<210> 20896
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 20896
tccaacauca aggaagaugg cat                                               23


<210> 20897
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 20897
tccaacauca aggaagaugg ca                                                22


<210> 20898
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 20898
tccaacauca aggaagaugg c                                                 21


<210> 20899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20899
tccaacauca aggaagaugg                                                   20


<210> 20900
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20900
tccaacauca aggaagatg                                                    19


<210> 20901
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20901
tccaacauca aggaagat                                                     18


<210> 20902
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20902
tccaacauca aggaaga                                                      17


<210> 20903
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20903
tccaacauca aggaag                                                       16


<210> 20904
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 20904
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 20905
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 20905
ccaacaucaa ggaagauggc auuucta                                           27


<210> 20906
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 20906
ccaacaucaa ggaagauggc auuuct                                            26


<210> 20907
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<400> 20907
ccaacaucaa ggaagauggc auutc                                             25


<210> 20908
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 20908
ccaacaucaa ggaagauggc autt                                              24


<210> 20909
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 20909
ccaacaucaa ggaagauggc att                                               23


<210> 20910
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 20910
ccaacaucaa ggaagauggc at                                                22


<210> 20911
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 20911
ccaacaucaa ggaagauggc a                                                 21


<210> 20912
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 20912
ccaacaucaa ggaagauggc                                                   20


<210> 20913
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20913
ccaacaucaa ggaagaugg                                                    19


<210> 20914
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20914
ccaacaucaa ggaagatg                                                     18


<210> 20915
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20915
ccaacaucaa ggaagat                                                      17


<210> 20916
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20916
ccaacaucaa ggaaga                                                       16


<210> 20917
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20917
ccaacaucaa ggaag                                                        15


<210> 20918
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 20918
caacaucaag gaagauggca uuucuag                                           27


<210> 20919
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 20919
caacaucaag gaagauggca uuucta                                            26


<210> 20920
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 20920
caacaucaag gaagauggca uuuct                                             25


<210> 20921
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<400> 20921
caacaucaag gaagauggca uutc                                              24


<210> 20922
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 20922
caacaucaag gaagauggca utt                                               23


<210> 20923
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 20923
caacaucaag gaagauggca tt                                                22


<210> 20924
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 20924
caacaucaag gaagauggca t                                                 21


<210> 20925
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20925
caacaucaag gaagauggca                                                   20


<210> 20926
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 20926
caacaucaag gaagauggc                                                    19


<210> 20927
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20927
caacaucaag gaagaugg                                                     18


<210> 20928
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20928
caacaucaag gaagatg                                                      17


<210> 20929
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20929
caacaucaag gaagat                                                       16


<210> 20930
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20930
caacaucaag gaaga                                                        15


<210> 20931
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20931
caacaucaag gaag                                                         14


<210> 20932
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 20932
aacaucaagg aagauggcau uucuag                                            26


<210> 20933
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 20933
aacaucaagg aagauggcau uucta                                             25


<210> 20934
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 20934
aacaucaagg aagauggcau uuct                                              24


<210> 20935
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 20935
aacaucaagg aagauggcau utc                                               23


<210> 20936
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 20936
aacaucaagg aagauggcau tt                                                22


<210> 20937
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 20937
aacaucaagg aagauggcat t                                                 21


<210> 20938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20938
aacaucaagg aagauggcat                                                   20


<210> 20939
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20939
aacaucaagg aagauggca                                                    19


<210> 20940
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 20940
aacaucaagg aagauggc                                                     18


<210> 20941
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20941
aacaucaagg aagaugg                                                      17


<210> 20942
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20942
aacaucaagg aagatg                                                       16


<210> 20943
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20943
aacaucaagg aagat                                                        15


<210> 20944
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20944
aacaucaagg aaga                                                         14


<210> 20945
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20945
aacaucaagg aag                                                          13


<210> 20946
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 20946
acaucaagga agauggcauu ucuag                                             25


<210> 20947
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 20947
acaucaagga agauggcauu ucta                                              24


<210> 20948
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 20948
acaucaagga agauggcauu uct                                               23


<210> 20949
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 20949
acaucaagga agauggcauu tc                                                22


<210> 20950
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 20950
acaucaagga agauggcaut t                                                 21


<210> 20951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20951
acaucaagga agauggcatt                                                   20


<210> 20952
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20952
acaucaagga agauggcat                                                    19


<210> 20953
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20953
acaucaagga agauggca                                                     18


<210> 20954
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 20954
acaucaagga agauggc                                                      17


<210> 20955
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20955
acaucaagga agaugg                                                       16


<210> 20956
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20956
acaucaagga agatg                                                        15


<210> 20957
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20957
acaucaagga agat                                                         14


<210> 20958
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20958
acaucaagga aga                                                          13


<210> 20959
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20959
acaucaagga ag                                                           12


<210> 20960
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 20960
caucaaggaa gauggcauuu cuag                                              24


<210> 20961
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 20961
caucaaggaa gauggcauuu cta                                               23


<210> 20962
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 20962
caucaaggaa gauggcauuu ct                                                22


<210> 20963
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 20963
caucaaggaa gauggcauut c                                                 21


<210> 20964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20964
caucaaggaa gauggcautt                                                   20


<210> 20965
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20965
caucaaggaa gauggcatt                                                    19


<210> 20966
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20966
caucaaggaa gauggcat                                                     18


<210> 20967
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20967
caucaaggaa gauggca                                                      17


<210> 20968
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 20968
caucaaggaa gauggc                                                       16


<210> 20969
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 20969
caucaaggaa gaugg                                                        15


<210> 20970
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20970
caucaaggaa gatg                                                         14


<210> 20971
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20971
caucaaggaa gat                                                          13


<210> 20972
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20972
caucaaggaa ga                                                           12


<210> 20973
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20973
caucaaggaa g                                                            11


<210> 20974
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 20974
atcaaggaag auggcauuuc uag                                               23


<210> 20975
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 20975
atcaaggaag auggcauuuc ta                                                22


<210> 20976
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 20976
atcaaggaag auggcauuuc t                                                 21


<210> 20977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 20977
atcaaggaag auggcauutc                                                   20


<210> 20978
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20978
atcaaggaag auggcautt                                                    19


<210> 20979
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20979
atcaaggaag auggcatt                                                     18


<210> 20980
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20980
atcaaggaag auggcat                                                      17


<210> 20981
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 20981
atcaaggaag auggca                                                       16


<210> 20982
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 20982
atcaaggaag auggc                                                        15


<210> 20983
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 20983
atcaaggaag augg                                                         14


<210> 20984
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 20984
atcaaggaag atg                                                          13


<210> 20985
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 20985
atcaaggaag at                                                           12


<210> 20986
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 20986
atcaaggaag a                                                            11


<210> 20987
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 20987
atcaaggaag                                                              10


<210> 20988
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 20988
ccagagcagg uaccuccaac atc                                               23


<210> 20989
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 20989
ccagagcagg uaccucca                                                     18


<210> 20990
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 20990
ccucugugau uuuauaacuu gat                                               23


<210> 20991
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 20991
tcacccacca ucaccct                                                      17


<210> 20992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 20992
tgauauccuc aaggucaccc                                                   20


<210> 20993
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 20993
ctgcuugaug aucaucucgu tg                                                22


<210> 20994
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 20994
ctgcuugaug aucauctc                                                     18


<210> 20995
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 20995
gtuuccuuag uaaccacag                                                    19


<210> 20996
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 20996
gtuuccuuag uaaccac                                                      17


<210> 20997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 20997
tcaaggaaga uggcauuuct                                                   20


<210> 20998
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 20998
tcaaggaaga uggcauuucu ag                                                22


<210> 20999
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 20999
gguaaguucu guccaagc                                                     18


<210> 21000
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 21000
gtaaguucug uccaagcc                                                     18


<210> 21001
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 21001
agucgguaag uucugucc                                                     18


<210> 21002
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21002
ctguccaagc ccgguuga                                                     18


<210> 21003
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21003
taaguucugu ccaag                                                        15


<210> 21004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21004
ttcuguccaa gcccgguuga                                                   20


<210> 21005
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21005
ttcuguccaa gcccggutg                                                    19


<210> 21006
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21006
ttcuguccaa gcccggtt                                                     18


<210> 21007
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21007
ttcuguccaa gcccggt                                                      17


<210> 21008
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21008
ttcuguccaa gcccgg                                                       16


<210> 21009
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21009
ttcuguccaa gcccg                                                        15


<210> 21010
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 21010
ttcuguccaa gccc                                                         14


<210> 21011
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 21011
ttcuguccaa gcc                                                          13


<210> 21012
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 21012
ttcuguccaa gc                                                           12


<210> 21013
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21013
ttcuguccaa g                                                            11


<210> 21014
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21014
ttcuguccaa                                                              10


<210> 21015
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21015
ttcugucca                                                                9


<210> 21016
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 21016
ttcugucc                                                                 8


<210> 21017
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21017
tcuguccaag cccgguuga                                                    19


<210> 21018
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21018
tcuguccaag cccggutg                                                     18


<210> 21019
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21019
tcuguccaag cccggtt                                                      17


<210> 21020
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21020
tcuguccaag cccggt                                                       16


<210> 21021
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21021
tcuguccaag cccgg                                                        15


<210> 21022
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21022
tcuguccaag cccg                                                         14


<210> 21023
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 21023
tcuguccaag ccc                                                          13


<210> 21024
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 21024
tcuguccaag cc                                                           12


<210> 21025
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 21025
tcuguccaag c                                                            11


<210> 21026
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21026
tcuguccaag                                                              10


<210> 21027
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21027
tcuguccaa                                                                9


<210> 21028
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21028
tcugucca                                                                 8


<210> 21029
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21029
ctguccaagc ccggutg                                                      17


<210> 21030
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21030
ctguccaagc ccggtt                                                       16


<210> 21031
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21031
ctguccaagc ccggt                                                        15


<210> 21032
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21032
ctguccaagc ccgg                                                         14


<210> 21033
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21033
ctguccaagc ccg                                                          13


<210> 21034
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 21034
ctguccaagc cc                                                           12


<210> 21035
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 21035
ctguccaagc c                                                            11


<210> 21036
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 21036
ctguccaagc                                                              10


<210> 21037
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21037
ctguccaag                                                                9


<210> 21038
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21038
ctguccaa                                                                 8


<210> 21039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21039
gtucugucca agcccggutg                                                   20


<210> 21040
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21040
gtucugucca agcccggtt                                                    19


<210> 21041
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21041
gtucugucca agcccggt                                                     18


<210> 21042
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21042
gtucugucca agcccgg                                                      17


<210> 21043
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21043
gtucugucca agcccg                                                       16


<210> 21044
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 21044
gtucugucca agccc                                                        15


<210> 21045
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 21045
gtucugucca agcc                                                         14


<210> 21046
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 21046
gtucugucca agc                                                          13


<210> 21047
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21047
gtucugucca ag                                                           12


<210> 21048
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21048
gtucugucca a                                                            11


<210> 21049
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21049
gtucugucca                                                              10


<210> 21050
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 21050
gtucugucc                                                                9


<210> 21051
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 21051
gtucugtc                                                                 8


<210> 21052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21052
aguucugucc aagcccggtt                                                   20


<210> 21053
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21053
aguucugucc aagcccggt                                                    19


<210> 21054
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21054
aguucugucc aagcccgg                                                     18


<210> 21055
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21055
aguucugucc aagcccg                                                      17


<210> 21056
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 21056
aguucugucc aagccc                                                       16


<210> 21057
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 21057
aguucugucc aagcc                                                        15


<210> 21058
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 21058
aguucugucc aagc                                                         14


<210> 21059
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21059
aguucugucc aag                                                          13


<210> 21060
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21060
aguucugucc aa                                                           12


<210> 21061
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21061
aguucugucc a                                                            11


<210> 21062
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 21062
aguucugucc                                                              10


<210> 21063
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 21063
aguucugtc                                                                9


<210> 21064
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21064
aguucugt                                                                 8


<210> 21065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21065
aaguucuguc caagcccggt                                                   20


<210> 21066
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21066
aaguucuguc caagcccgg                                                    19


<210> 21067
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21067
aaguucuguc caagcccg                                                     18


<210> 21068
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 21068
aaguucuguc caagccc                                                      17


<210> 21069
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 21069
aaguucuguc caagcc                                                       16


<210> 21070
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 21070
aaguucuguc caagc                                                        15


<210> 21071
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21071
aaguucuguc caag                                                         14


<210> 21072
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21072
aaguucuguc caa                                                          13


<210> 21073
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21073
aaguucuguc ca                                                           12


<210> 21074
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 21074
aaguucuguc c                                                            11


<210> 21075
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 21075
aaguucugtc                                                              10


<210> 21076
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21076
aaguucugt                                                                9


<210> 21077
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21077
aaguuctg                                                                 8


<210> 21078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21078
taaguucugu ccaagcccgg                                                   20


<210> 21079
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21079
taaguucugu ccaagcccg                                                    19


<210> 21080
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 21080
taaguucugu ccaagccc                                                     18


<210> 21081
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 21081
taaguucugu ccaagcc                                                      17


<210> 21082
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 21082
taaguucugu ccaagc                                                       16


<210> 21083
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21083
taaguucugu ccaa                                                         14


<210> 21084
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21084
taaguucugu cca                                                          13


<210> 21085
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 21085
taaguucugu cc                                                           12


<210> 21086
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 21086
taaguucugt c                                                            11


<210> 21087
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21087
taaguucugt                                                              10


<210> 21088
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21088
taaguuctg                                                                9


<210> 21089
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21089
taaguuct                                                                 8


<210> 21090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21090
gtaaguucug uccaagcccg                                                   20


<210> 21091
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 21091
gtaaguucug uccaagccc                                                    19


<210> 21092
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 21092
gtaaguucug uccaagc                                                      17


<210> 21093
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21093
gtaaguucug uccaag                                                       16


<210> 21094
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21094
gtaaguucug uccaa                                                        15


<210> 21095
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21095
gtaaguucug ucca                                                         14


<210> 21096
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 21096
gtaaguucug ucc                                                          13


<210> 21097
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 21097
gtaaguucug tc                                                           12


<210> 21098
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21098
gtaaguucug t                                                            11


<210> 21099
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21099
gtaaguuctg                                                              10


<210> 21100
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21100
gtaaguuct                                                                9


<210> 21101
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 21101
gtaagutc                                                                 8


<210> 21102
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 21102
gguaaguucu guccaagccc                                                   20


<210> 21103
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 21103
gguaaguucu guccaagcc                                                    19


<210> 21104
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21104
gguaaguucu guccaag                                                      17


<210> 21105
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21105
gguaaguucu guccaa                                                       16


<210> 21106
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21106
gguaaguucu gucca                                                        15


<210> 21107
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 21107
gguaaguucu gucc                                                         14


<210> 21108
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 21108
gguaaguucu gtc                                                          13


<210> 21109
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21109
gguaaguucu gt                                                           12


<210> 21110
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21110
gguaaguuct g                                                            11


<210> 21111
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21111
gguaaguuct                                                              10


<210> 21112
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 21112
gguaagutc                                                                9


<210> 21113
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21113
gguaagtt                                                                 8


<210> 21114
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 21114
cgguaaguuc uguccaagcc                                                   20


<210> 21115
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 21115
cgguaaguuc uguccaagc                                                    19


<210> 21116
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21116
cgguaaguuc uguccaag                                                     18


<210> 21117
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21117
cgguaaguuc uguccaa                                                      17


<210> 21118
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21118
cgguaaguuc ugucca                                                       16


<210> 21119
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 21119
cgguaaguuc ugucc                                                        15


<210> 21120
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 21120
cgguaaguuc ugtc                                                         14


<210> 21121
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21121
cgguaaguuc ugt                                                          13


<210> 21122
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21122
cgguaaguuc tg                                                           12


<210> 21123
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21123
cgguaaguuc t                                                            11


<210> 21124
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 21124
cgguaagutc                                                              10


<210> 21125
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21125
cgguaagtt                                                                9


<210> 21126
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21126
cgguaagt                                                                 8


<210> 21127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 21127
tcgguaaguu cuguccaagc                                                   20


<210> 21128
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21128
tcgguaaguu cuguccaag                                                    19


<210> 21129
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21129
tcgguaaguu cuguccaa                                                     18


<210> 21130
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21130
tcgguaaguu cugucca                                                      17


<210> 21131
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 21131
tcgguaaguu cugucc                                                       16


<210> 21132
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 21132
tcgguaaguu cugtc                                                        15


<210> 21133
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21133
tcgguaaguu cugt                                                         14


<210> 21134
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21134
tcgguaaguu ctg                                                          13


<210> 21135
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21135
tcgguaaguu ct                                                           12


<210> 21136
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<400> 21136
tcgguaagut c                                                            11


<210> 21137
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21137
tcgguaagtt                                                              10


<210> 21138
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21138
tcgguaagt                                                                9


<210> 21139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21139
gtcgguaagu ucuguccaag                                                   20


<210> 21140
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21140
gtcgguaagu ucuguccaa                                                    19


<210> 21141
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21141
gtcgguaagu ucugucca                                                     18


<210> 21142
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 21142
gtcgguaagu ucugucc                                                      17


<210> 21143
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 21143
gtcgguaagu ucugtc                                                       16


<210> 21144
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21144
gtcgguaagu ucugt                                                        15


<210> 21145
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21145
gtcgguaagu uctg                                                         14


<210> 21146
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21146
gtcgguaagu uct                                                          13


<210> 21147
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 21147
gtcgguaagu tc                                                           12


<210> 21148
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21148
gtcgguaagt t                                                            11


<210> 21149
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21149
gtcgguaagt                                                              10


<210> 21150
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21150
agucgguaag uucuguccaa                                                   20


<210> 21151
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21151
agucgguaag uucugucca                                                    19


<210> 21152
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 21152
agucgguaag uucugtc                                                      17


<210> 21153
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21153
agucgguaag uucugt                                                       16


<210> 21154
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21154
agucgguaag uuctg                                                        15


<210> 21155
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21155
agucgguaag uuct                                                         14


<210> 21156
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 21156
agucgguaag utc                                                          13


<210> 21157
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21157
agucgguaag tt                                                           12


<210> 21158
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21158
agucgguaag t                                                            11


<210> 21159
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21159
cagucgguaa guucugucca                                                   20


<210> 21160
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 21160
cagucgguaa guucugucc                                                    19


<210> 21161
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 21161
cagucgguaa guucugtc                                                     18


<210> 21162
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21162
cagucgguaa guucugt                                                      17


<210> 21163
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21163
cagucgguaa guuctg                                                       16


<210> 21164
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21164
cagucgguaa guuct                                                        15


<210> 21165
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 21165
cagucgguaa gutc                                                         14


<210> 21166
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21166
cagucgguaa gtt                                                          13


<210> 21167
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21167
cagucgguaa gt                                                           12


<210> 21168
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 21168
ccagucggua aguucugucc                                                   20


<210> 21169
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 21169
ccagucggua aguucugtc                                                    19


<210> 21170
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21170
ccagucggua aguucugt                                                     18


<210> 21171
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21171
ccagucggua aguuctg                                                      17


<210> 21172
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21172
ccagucggua aguuct                                                       16


<210> 21173
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 21173
ccagucggua agutc                                                        15


<210> 21174
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21174
ccagucggua agtt                                                         14


<210> 21175
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21175
ccagucggua agt                                                          13


<210> 21176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 21176
gccagucggu aaguucugtc                                                   20


<210> 21177
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21177
gccagucggu aaguucugt                                                    19


<210> 21178
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21178
gccagucggu aaguuctg                                                     18


<210> 21179
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21179
gccagucggu aaguuct                                                      17


<210> 21180
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 21180
gccagucggu aagutc                                                       16


<210> 21181
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21181
gccagucggu aagtt                                                        15


<210> 21182
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21182
gccagucggu aagt                                                         14


<210> 21183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21183
tcaaggaaga uggcauuuct                                                   20


<210> 21184
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 21184
tcaaggaaga uggcauuucu ag                                                22


<210> 21185
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21185
tcaaggaaga uggcat                                                       16


<210> 21186
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21186
gaagauggca uuuct                                                        15


<210> 21187
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 21187
tcaaggaaga uggcauuuct a                                                 21


<210> 21188
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 21188
tcaaggaaga uggcauutc                                                    19


<210> 21189
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21189
tcaaggaaga uggcautt                                                     18


<210> 21190
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21190
tcaaggaaga uggcatt                                                      17


<210> 21191
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21191
tcaaggaaga uggca                                                        15


<210> 21192
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 21192
tcaaggaaga uggc                                                         14


<210> 21193
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21193
tcaaggaaga ugg                                                          13


<210> 21194
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21194
tcaaggaaga tg                                                           12


<210> 21195
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21195
tcaaggaaga t                                                            11


<210> 21196
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21196
tcaaggaaga                                                              10


<210> 21197
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21197
tcaaggaag                                                                9


<210> 21198
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 21198
caaggaagau ggcauuucua g                                                 21


<210> 21199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21199
caaggaagau ggcauuucta                                                   20


<210> 21200
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21200
caaggaagau ggcauuuct                                                    19


<210> 21201
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 21201
caaggaagau ggcauutc                                                     18


<210> 21202
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21202
caaggaagau ggcautt                                                      17


<210> 21203
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21203
caaggaagau ggcatt                                                       16


<210> 21204
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21204
caaggaagau ggcat                                                        15


<210> 21205
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21205
caaggaagau ggca                                                         14


<210> 21206
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 21206
caaggaagau ggc                                                          13


<210> 21207
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21207
caaggaagau gg                                                           12


<210> 21208
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21208
caaggaagat g                                                            11


<210> 21209
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21209
caaggaagat                                                              10


<210> 21210
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21210
caaggaaga                                                                9


<210> 21211
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21211
caaggaag                                                                 8


<210> 21212
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21212
aaggaagaug gcauuucuag                                                   20


<210> 21213
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21213
aaggaagaug gcauuucta                                                    19


<210> 21214
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21214
aaggaagaug gcauuuct                                                     18


<210> 21215
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 21215
aaggaagaug gcauutc                                                      17


<210> 21216
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21216
aaggaagaug gcautt                                                       16


<210> 21217
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21217
aaggaagaug gcatt                                                        15


<210> 21218
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21218
aaggaagaug gcat                                                         14


<210> 21219
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21219
aaggaagaug gca                                                          13


<210> 21220
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 21220
aaggaagaug gc                                                           12


<210> 21221
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21221
aaggaagaug g                                                            11


<210> 21222
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21222
aaggaagatg                                                              10


<210> 21223
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21223
aaggaagat                                                                9


<210> 21224
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21224
aaggaaga                                                                 8


<210> 21225
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21225
aggaagaugg cauuucuag                                                    19


<210> 21226
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21226
aggaagaugg cauuucta                                                     18


<210> 21227
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21227
aggaagaugg cauuuct                                                      17


<210> 21228
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 21228
aggaagaugg cauutc                                                       16


<210> 21229
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21229
aggaagaugg cautt                                                        15


<210> 21230
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21230
aggaagaugg catt                                                         14


<210> 21231
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21231
aggaagaugg cat                                                          13


<210> 21232
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21232
aggaagaugg ca                                                           12


<210> 21233
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21233
aggaagaugg                                                              10


<210> 21234
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21234
aggaagatg                                                                9


<210> 21235
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21235
aggaagat                                                                 8


<210> 21236
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21236
ggaagauggc auuucuag                                                     18


<210> 21237
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21237
ggaagauggc auuucta                                                      17


<210> 21238
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21238
ggaagauggc auuuct                                                       16


<210> 21239
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 21239
ggaagauggc auutc                                                        15


<210> 21240
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21240
ggaagauggc autt                                                         14


<210> 21241
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21241
ggaagauggc att                                                          13


<210> 21242
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21242
ggaagauggc at                                                           12


<210> 21243
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21243
ggaagauggc a                                                            11


<210> 21244
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<400> 21244
ggaagauggc                                                              10


<210> 21245
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21245
ggaagatg                                                                 8


<210> 21246
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21246
gaagauggca uuucuag                                                      17


<210> 21247
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21247
gaagauggca uuucta                                                       16


<210> 21248
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<400> 21248
gaagauggca uutc                                                         14


<210> 21249
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21249
gaagauggca utt                                                          13


<210> 21250
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21250
gaagauggca tt                                                           12


<210> 21251
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21251
gaagauggca t                                                            11


<210> 21252
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21252
gaagauggca                                                              10


<210> 21253
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<400> 21253
gaagauggc                                                                9


<210> 21254
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21254
gaagaugg                                                                 8


<210> 21255
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21255
aagauggcau uucuag                                                       16


<210> 21256
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21256
aagauggcau uucta                                                        15


<210> 21257
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21257
aagauggcau uuct                                                         14


<210> 21258
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<400> 21258
aagauggcau utc                                                          13


<210> 21259
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21259
aagauggcau tt                                                           12


<210> 21260
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21260
aagauggcat t                                                            11


<210> 21261
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21261
aagauggcat                                                              10


<210> 21262
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21262
aagauggca                                                                9


<210> 21263
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<400> 21263
aagauggc                                                                 8


<210> 21264
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21264
agauggcauu ucuag                                                        15


<210> 21265
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21265
agauggcauu ucta                                                         14


<210> 21266
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21266
agauggcauu uct                                                          13


<210> 21267
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<400> 21267
agauggcauu tc                                                           12


<210> 21268
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21268
agauggcaut t                                                            11


<210> 21269
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21269
agauggcatt                                                              10


<210> 21270
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<400> 21270
agauggcat                                                                9


<210> 21271
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<400> 21271
agauggca                                                                 8


<210> 21272
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<400> 21272
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 21273
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 21273
ctccaacauc aaggaagaug gcauuucta                                         29


<210> 21274
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 21274
ctccaacauc aaggaagaug gcauuuct                                          28


<210> 21275
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<400> 21275
ctccaacauc aaggaagaug gcauutc                                           27


<210> 21276
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 21276
ctccaacauc aaggaagaug gcautt                                            26


<210> 21277
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 21277
ctccaacauc aaggaagaug gcatt                                             25


<210> 21278
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 21278
ctccaacauc aaggaagaug gcat                                              24


<210> 21279
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 21279
ctccaacauc aaggaagaug gca                                               23


<210> 21280
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 21280
ctccaacauc aaggaagaug gc                                                22


<210> 21281
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 21281
ctccaacauc aaggaagaug g                                                 21


<210> 21282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21282
ctccaacauc aaggaagatg                                                   20


<210> 21283
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21283
ctccaacauc aaggaagat                                                    19


<210> 21284
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21284
ctccaacauc aaggaaga                                                     18


<210> 21285
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21285
ctccaacauc aaggaag                                                      17


<210> 21286
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<400> 21286
tccaacauca aggaagaugg cauuucuag                                         29


<210> 21287
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 21287
tccaacauca aggaagaugg cauuucta                                          28


<210> 21288
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 21288
tccaacauca aggaagaugg cauuuct                                           27


<210> 21289
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<400> 21289
tccaacauca aggaagaugg cauutc                                            26


<210> 21290
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 21290
tccaacauca aggaagaugg cautt                                             25


<210> 21291
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 21291
tccaacauca aggaagaugg catt                                              24


<210> 21292
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 21292
tccaacauca aggaagaugg cat                                               23


<210> 21293
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 21293
tccaacauca aggaagaugg ca                                                22


<210> 21294
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 21294
tccaacauca aggaagaugg c                                                 21


<210> 21295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21295
tccaacauca aggaagaugg                                                   20


<210> 21296
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21296
tccaacauca aggaagatg                                                    19


<210> 21297
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21297
tccaacauca aggaagat                                                     18


<210> 21298
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21298
tccaacauca aggaaga                                                      17


<210> 21299
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21299
tccaacauca aggaag                                                       16


<210> 21300
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<400> 21300
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 21301
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 21301
ccaacaucaa ggaagauggc auuucta                                           27


<210> 21302
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 21302
ccaacaucaa ggaagauggc auuuct                                            26


<210> 21303
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<400> 21303
ccaacaucaa ggaagauggc auutc                                             25


<210> 21304
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 21304
ccaacaucaa ggaagauggc autt                                              24


<210> 21305
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 21305
ccaacaucaa ggaagauggc att                                               23


<210> 21306
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 21306
ccaacaucaa ggaagauggc at                                                22


<210> 21307
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 21307
ccaacaucaa ggaagauggc a                                                 21


<210> 21308
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 21308
ccaacaucaa ggaagauggc                                                   20


<210> 21309
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21309
ccaacaucaa ggaagaugg                                                    19


<210> 21310
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21310
ccaacaucaa ggaagatg                                                     18


<210> 21311
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21311
ccaacaucaa ggaagat                                                      17


<210> 21312
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21312
ccaacaucaa ggaaga                                                       16


<210> 21313
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21313
ccaacaucaa ggaag                                                        15


<210> 21314
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<400> 21314
caacaucaag gaagauggca uuucuag                                           27


<210> 21315
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 21315
caacaucaag gaagauggca uuucta                                            26


<210> 21316
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 21316
caacaucaag gaagauggca uuuct                                             25


<210> 21317
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<400> 21317
caacaucaag gaagauggca uutc                                              24


<210> 21318
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 21318
caacaucaag gaagauggca utt                                               23


<210> 21319
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 21319
caacaucaag gaagauggca tt                                                22


<210> 21320
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 21320
caacaucaag gaagauggca t                                                 21


<210> 21321
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21321
caacaucaag gaagauggca                                                   20


<210> 21322
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<400> 21322
caacaucaag gaagauggc                                                    19


<210> 21323
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21323
caacaucaag gaagaugg                                                     18


<210> 21324
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21324
caacaucaag gaagatg                                                      17


<210> 21325
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21325
caacaucaag gaagat                                                       16


<210> 21326
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21326
caacaucaag gaaga                                                        15


<210> 21327
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21327
caacaucaag gaag                                                         14


<210> 21328
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<400> 21328
aacaucaagg aagauggcau uucuag                                            26


<210> 21329
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 21329
aacaucaagg aagauggcau uucta                                             25


<210> 21330
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 21330
aacaucaagg aagauggcau uuct                                              24


<210> 21331
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 21331
aacaucaagg aagauggcau utc                                               23


<210> 21332
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 21332
aacaucaagg aagauggcau tt                                                22


<210> 21333
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 21333
aacaucaagg aagauggcat t                                                 21


<210> 21334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21334
aacaucaagg aagauggcat                                                   20


<210> 21335
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21335
aacaucaagg aagauggca                                                    19


<210> 21336
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 21336
aacaucaagg aagauggc                                                     18


<210> 21337
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21337
aacaucaagg aagaugg                                                      17


<210> 21338
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21338
aacaucaagg aagatg                                                       16


<210> 21339
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21339
aacaucaagg aagat                                                        15


<210> 21340
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21340
aacaucaagg aaga                                                         14


<210> 21341
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21341
aacaucaagg aag                                                          13


<210> 21342
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<400> 21342
acaucaagga agauggcauu ucuag                                             25


<210> 21343
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 21343
acaucaagga agauggcauu ucta                                              24


<210> 21344
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 21344
acaucaagga agauggcauu uct                                               23


<210> 21345
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<400> 21345
acaucaagga agauggcauu tc                                                22


<210> 21346
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 21346
acaucaagga agauggcaut t                                                 21


<210> 21347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21347
acaucaagga agauggcatt                                                   20


<210> 21348
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21348
acaucaagga agauggcat                                                    19


<210> 21349
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21349
acaucaagga agauggca                                                     18


<210> 21350
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 21350
acaucaagga agauggc                                                      17


<210> 21351
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21351
acaucaagga agaugg                                                       16


<210> 21352
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21352
acaucaagga agatg                                                        15


<210> 21353
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21353
acaucaagga agat                                                         14


<210> 21354
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21354
acaucaagga aga                                                          13


<210> 21355
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21355
acaucaagga ag                                                           12


<210> 21356
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<400> 21356
caucaaggaa gauggcauuu cuag                                              24


<210> 21357
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 21357
caucaaggaa gauggcauuu cta                                               23


<210> 21358
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 21358
caucaaggaa gauggcauuu ct                                                22


<210> 21359
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<400> 21359
caucaaggaa gauggcauut c                                                 21


<210> 21360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 21360
caucaaggaa gauggcautt                                                   20


<210> 21361
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21361
caucaaggaa gauggcatt                                                    19


<210> 21362
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21362
caucaaggaa gauggcat                                                     18


<210> 21363
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21363
caucaaggaa gauggca                                                      17


<210> 21364
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<400> 21364
caucaaggaa gauggc                                                       16


<210> 21365
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<400> 21365
caucaaggaa gaugg                                                        15


<210> 21366
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21366
caucaaggaa gatg                                                         14


<210> 21367
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21367
caucaaggaa gat                                                          13


<210> 21368
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21368
caucaaggaa ga                                                           12


<210> 21369
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21369
caucaaggaa g                                                            11


<210> 21370
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 21370
atcaaggaag auggcauuuc uag                                               23


<210> 21371
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 21371
atcaaggaag auggcauuuc ta                                                22


<210> 21372
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<400> 21372
atcaaggaag auggcauuuc t                                                 21


<210> 21373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 21373
atcaaggaag auggcauutc                                                   20


<210> 21374
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21374
atcaaggaag auggcautt                                                    19


<210> 21375
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21375
atcaaggaag auggcatt                                                     18


<210> 21376
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21376
atcaaggaag auggcat                                                      17


<210> 21377
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<400> 21377
atcaaggaag auggca                                                       16


<210> 21378
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<400> 21378
atcaaggaag auggc                                                        15


<210> 21379
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<400> 21379
atcaaggaag augg                                                         14


<210> 21380
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 21380
atcaaggaag atg                                                          13


<210> 21381
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<400> 21381
atcaaggaag at                                                           12


<210> 21382
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<400> 21382
atcaaggaag a                                                            11


<210> 21383
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<400> 21383
atcaaggaag                                                              10


<210> 21384
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<400> 21384
ccagagcagg uaccuccaac atc                                               23


<210> 21385
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 21385
ccagagcagg uaccucca                                                     18


<210> 21386
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<400> 21386
ccucugugau uuuauaacuu gat                                               23


<210> 21387
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<400> 21387
tcacccacca ucaccct                                                      17


<210> 21388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<400> 21388
tgauauccuc aaggucaccc                                                   20


<210> 21389
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 21389
ctgcuugaug aucaucucgu tg                                                22


<210> 21390
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 21390
ctgcuugaug aucauctc                                                     18


<210> 21391
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<400> 21391
gtuuccuuag uaaccacag                                                    19


<210> 21392
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<400> 21392
gtuuccuuag uaaccac                                                      17


<210> 21393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21393
tcaaggaaga uggcauuuct                                                   20


<210> 21394
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21394
tcaaggaaga uggcauuucu ag                                                22


<210> 21395
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21395
gguaaguucu guccaagc                                                     18


<210> 21396
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21396
gtaaguucug uccaagcc                                                     18


<210> 21397
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21397
agucgguaag uucugucc                                                     18


<210> 21398
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21398
ctguccaagc ccgguuga                                                     18


<210> 21399
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21399
taaguucugu ccaag                                                        15


<210> 21400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21400
ttcuguccaa gcccgguuga                                                   20


<210> 21401
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21401
ttcuguccaa gcccggutg                                                    19


<210> 21402
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21402
ttcuguccaa gcccggtt                                                     18


<210> 21403
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21403
ttcuguccaa gcccggt                                                      17


<210> 21404
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21404
ttcuguccaa gcccgg                                                       16


<210> 21405
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21405
ttcuguccaa gcccg                                                        15


<210> 21406
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21406
ttcuguccaa gccc                                                         14


<210> 21407
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21407
ttcuguccaa gcc                                                          13


<210> 21408
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21408
ttcuguccaa gc                                                           12


<210> 21409
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21409
ttcuguccaa g                                                            11


<210> 21410
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21410
ttcuguccaa                                                              10


<210> 21411
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21411
ttcugucca                                                                9


<210> 21412
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21412
ttcugucc                                                                 8


<210> 21413
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21413
tcuguccaag cccgguuga                                                    19


<210> 21414
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21414
tcuguccaag cccggutg                                                     18


<210> 21415
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21415
tcuguccaag cccggtt                                                      17


<210> 21416
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21416
tcuguccaag cccggt                                                       16


<210> 21417
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21417
tcuguccaag cccgg                                                        15


<210> 21418
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21418
tcuguccaag cccg                                                         14


<210> 21419
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21419
tcuguccaag ccc                                                          13


<210> 21420
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21420
tcuguccaag cc                                                           12


<210> 21421
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21421
tcuguccaag c                                                            11


<210> 21422
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21422
tcuguccaag                                                              10


<210> 21423
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21423
tcuguccaa                                                                9


<210> 21424
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21424
tcugucca                                                                 8


<210> 21425
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21425
ctguccaagc ccggutg                                                      17


<210> 21426
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21426
ctguccaagc ccggtt                                                       16


<210> 21427
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21427
ctguccaagc ccggt                                                        15


<210> 21428
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21428
ctguccaagc ccgg                                                         14


<210> 21429
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21429
ctguccaagc ccg                                                          13


<210> 21430
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21430
ctguccaagc cc                                                           12


<210> 21431
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21431
ctguccaagc c                                                            11


<210> 21432
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21432
ctguccaagc                                                              10


<210> 21433
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21433
ctguccaag                                                                9


<210> 21434
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21434
ctguccaa                                                                 8


<210> 21435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21435
gtucugucca agcccggutg                                                   20


<210> 21436
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21436
gtucugucca agcccggtt                                                    19


<210> 21437
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21437
gtucugucca agcccggt                                                     18


<210> 21438
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21438
gtucugucca agcccgg                                                      17


<210> 21439
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21439
gtucugucca agcccg                                                       16


<210> 21440
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21440
gtucugucca agccc                                                        15


<210> 21441
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21441
gtucugucca agcc                                                         14


<210> 21442
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21442
gtucugucca agc                                                          13


<210> 21443
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21443
gtucugucca ag                                                           12


<210> 21444
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21444
gtucugucca a                                                            11


<210> 21445
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21445
gtucugucca                                                              10


<210> 21446
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21446
gtucugucc                                                                9


<210> 21447
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21447
gtucugtc                                                                 8


<210> 21448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21448
aguucugucc aagcccggtt                                                   20


<210> 21449
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21449
aguucugucc aagcccggt                                                    19


<210> 21450
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21450
aguucugucc aagcccgg                                                     18


<210> 21451
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21451
aguucugucc aagcccg                                                      17


<210> 21452
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21452
aguucugucc aagccc                                                       16


<210> 21453
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21453
aguucugucc aagcc                                                        15


<210> 21454
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21454
aguucugucc aagc                                                         14


<210> 21455
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21455
aguucugucc aag                                                          13


<210> 21456
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21456
aguucugucc aa                                                           12


<210> 21457
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21457
aguucugucc a                                                            11


<210> 21458
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21458
aguucugucc                                                              10


<210> 21459
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21459
aguucugtc                                                                9


<210> 21460
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21460
aguucugt                                                                 8


<210> 21461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21461
aaguucuguc caagcccggt                                                   20


<210> 21462
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21462
aaguucuguc caagcccgg                                                    19


<210> 21463
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21463
aaguucuguc caagcccg                                                     18


<210> 21464
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21464
aaguucuguc caagccc                                                      17


<210> 21465
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21465
aaguucuguc caagcc                                                       16


<210> 21466
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21466
aaguucuguc caagc                                                        15


<210> 21467
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21467
aaguucuguc caag                                                         14


<210> 21468
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21468
aaguucuguc caa                                                          13


<210> 21469
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21469
aaguucuguc ca                                                           12


<210> 21470
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21470
aaguucuguc c                                                            11


<210> 21471
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21471
aaguucugtc                                                              10


<210> 21472
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21472
aaguucugt                                                                9


<210> 21473
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21473
aaguuctg                                                                 8


<210> 21474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21474
taaguucugu ccaagcccgg                                                   20


<210> 21475
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21475
taaguucugu ccaagcccg                                                    19


<210> 21476
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21476
taaguucugu ccaagccc                                                     18


<210> 21477
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21477
taaguucugu ccaagcc                                                      17


<210> 21478
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21478
taaguucugu ccaagc                                                       16


<210> 21479
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21479
taaguucugu ccaa                                                         14


<210> 21480
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21480
taaguucugu cca                                                          13


<210> 21481
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21481
taaguucugu cc                                                           12


<210> 21482
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21482
taaguucugt c                                                            11


<210> 21483
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21483
taaguucugt                                                              10


<210> 21484
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21484
taaguuctg                                                                9


<210> 21485
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21485
taaguuct                                                                 8


<210> 21486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21486
gtaaguucug uccaagcccg                                                   20


<210> 21487
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21487
gtaaguucug uccaagccc                                                    19


<210> 21488
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21488
gtaaguucug uccaagc                                                      17


<210> 21489
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21489
gtaaguucug uccaag                                                       16


<210> 21490
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21490
gtaaguucug uccaa                                                        15


<210> 21491
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21491
gtaaguucug ucca                                                         14


<210> 21492
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21492
gtaaguucug ucc                                                          13


<210> 21493
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21493
gtaaguucug tc                                                           12


<210> 21494
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21494
gtaaguucug t                                                            11


<210> 21495
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21495
gtaaguuctg                                                              10


<210> 21496
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21496
gtaaguuct                                                                9


<210> 21497
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21497
gtaagutc                                                                 8


<210> 21498
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21498
gguaaguucu guccaagccc                                                   20


<210> 21499
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21499
gguaaguucu guccaagcc                                                    19


<210> 21500
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21500
gguaaguucu guccaag                                                      17


<210> 21501
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21501
gguaaguucu guccaa                                                       16


<210> 21502
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21502
gguaaguucu gucca                                                        15


<210> 21503
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21503
gguaaguucu gucc                                                         14


<210> 21504
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21504
gguaaguucu gtc                                                          13


<210> 21505
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21505
gguaaguucu gt                                                           12


<210> 21506
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21506
gguaaguuct g                                                            11


<210> 21507
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21507
gguaaguuct                                                              10


<210> 21508
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21508
gguaagutc                                                                9


<210> 21509
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21509
gguaagtt                                                                 8


<210> 21510
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21510
cgguaaguuc uguccaagcc                                                   20


<210> 21511
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21511
cgguaaguuc uguccaagc                                                    19


<210> 21512
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21512
cgguaaguuc uguccaag                                                     18


<210> 21513
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21513
cgguaaguuc uguccaa                                                      17


<210> 21514
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21514
cgguaaguuc ugucca                                                       16


<210> 21515
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21515
cgguaaguuc ugucc                                                        15


<210> 21516
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21516
cgguaaguuc ugtc                                                         14


<210> 21517
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21517
cgguaaguuc ugt                                                          13


<210> 21518
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21518
cgguaaguuc tg                                                           12


<210> 21519
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21519
cgguaaguuc t                                                            11


<210> 21520
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21520
cgguaagutc                                                              10


<210> 21521
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21521
cgguaagtt                                                                9


<210> 21522
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21522
cgguaagt                                                                 8


<210> 21523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21523
tcgguaaguu cuguccaagc                                                   20


<210> 21524
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21524
tcgguaaguu cuguccaag                                                    19


<210> 21525
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21525
tcgguaaguu cuguccaa                                                     18


<210> 21526
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21526
tcgguaaguu cugucca                                                      17


<210> 21527
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21527
tcgguaaguu cugucc                                                       16


<210> 21528
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21528
tcgguaaguu cugtc                                                        15


<210> 21529
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21529
tcgguaaguu cugt                                                         14


<210> 21530
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21530
tcgguaaguu ctg                                                          13


<210> 21531
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21531
tcgguaaguu ct                                                           12


<210> 21532
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21532
tcgguaagut c                                                            11


<210> 21533
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21533
tcgguaagtt                                                              10


<210> 21534
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21534
tcgguaagt                                                                9


<210> 21535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21535
gtcgguaagu ucuguccaag                                                   20


<210> 21536
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21536
gtcgguaagu ucuguccaa                                                    19


<210> 21537
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21537
gtcgguaagu ucugucca                                                     18


<210> 21538
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21538
gtcgguaagu ucugucc                                                      17


<210> 21539
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21539
gtcgguaagu ucugtc                                                       16


<210> 21540
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21540
gtcgguaagu ucugt                                                        15


<210> 21541
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21541
gtcgguaagu uctg                                                         14


<210> 21542
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21542
gtcgguaagu uct                                                          13


<210> 21543
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21543
gtcgguaagu tc                                                           12


<210> 21544
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21544
gtcgguaagt t                                                            11


<210> 21545
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21545
gtcgguaagt                                                              10


<210> 21546
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21546
agucgguaag uucuguccaa                                                   20


<210> 21547
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21547
agucgguaag uucugucca                                                    19


<210> 21548
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21548
agucgguaag uucugtc                                                      17


<210> 21549
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21549
agucgguaag uucugt                                                       16


<210> 21550
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21550
agucgguaag uuctg                                                        15


<210> 21551
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21551
agucgguaag uuct                                                         14


<210> 21552
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21552
agucgguaag utc                                                          13


<210> 21553
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21553
agucgguaag tt                                                           12


<210> 21554
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21554
agucgguaag t                                                            11


<210> 21555
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21555
cagucgguaa guucugucca                                                   20


<210> 21556
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21556
cagucgguaa guucugucc                                                    19


<210> 21557
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21557
cagucgguaa guucugtc                                                     18


<210> 21558
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21558
cagucgguaa guucugt                                                      17


<210> 21559
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21559
cagucgguaa guuctg                                                       16


<210> 21560
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21560
cagucgguaa guuct                                                        15


<210> 21561
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21561
cagucgguaa gutc                                                         14


<210> 21562
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21562
cagucgguaa gtt                                                          13


<210> 21563
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21563
cagucgguaa gt                                                           12


<210> 21564
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21564
ccagucggua aguucugucc                                                   20


<210> 21565
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21565
ccagucggua aguucugtc                                                    19


<210> 21566
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21566
ccagucggua aguucugt                                                     18


<210> 21567
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21567
ccagucggua aguuctg                                                      17


<210> 21568
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21568
ccagucggua aguuct                                                       16


<210> 21569
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21569
ccagucggua agutc                                                        15


<210> 21570
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21570
ccagucggua agtt                                                         14


<210> 21571
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21571
ccagucggua agt                                                          13


<210> 21572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21572
gccagucggu aaguucugtc                                                   20


<210> 21573
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21573
gccagucggu aaguucugt                                                    19


<210> 21574
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21574
gccagucggu aaguuctg                                                     18


<210> 21575
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21575
gccagucggu aaguuct                                                      17


<210> 21576
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21576
gccagucggu aagutc                                                       16


<210> 21577
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21577
gccagucggu aagtt                                                        15


<210> 21578
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21578
gccagucggu aagt                                                         14


<210> 21579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21579
tcaaggaaga uggcauuuct                                                   20


<210> 21580
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21580
tcaaggaaga uggcauuucu ag                                                22


<210> 21581
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21581
tcaaggaaga uggcat                                                       16


<210> 21582
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21582
gaagauggca uuuct                                                        15


<210> 21583
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21583
tcaaggaaga uggcauuuct a                                                 21


<210> 21584
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21584
tcaaggaaga uggcauutc                                                    19


<210> 21585
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21585
tcaaggaaga uggcautt                                                     18


<210> 21586
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21586
tcaaggaaga uggcatt                                                      17


<210> 21587
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21587
tcaaggaaga uggca                                                        15


<210> 21588
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21588
tcaaggaaga uggc                                                         14


<210> 21589
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21589
tcaaggaaga ugg                                                          13


<210> 21590
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21590
tcaaggaaga tg                                                           12


<210> 21591
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21591
tcaaggaaga t                                                            11


<210> 21592
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21592
tcaaggaaga                                                              10


<210> 21593
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21593
tcaaggaag                                                                9


<210> 21594
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21594
caaggaagau ggcauuucua g                                                 21


<210> 21595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21595
caaggaagau ggcauuucta                                                   20


<210> 21596
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21596
caaggaagau ggcauuuct                                                    19


<210> 21597
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21597
caaggaagau ggcauutc                                                     18


<210> 21598
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21598
caaggaagau ggcautt                                                      17


<210> 21599
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21599
caaggaagau ggcatt                                                       16


<210> 21600
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21600
caaggaagau ggcat                                                        15


<210> 21601
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21601
caaggaagau ggca                                                         14


<210> 21602
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21602
caaggaagau ggc                                                          13


<210> 21603
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21603
caaggaagau gg                                                           12


<210> 21604
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21604
caaggaagat g                                                            11


<210> 21605
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21605
caaggaagat                                                              10


<210> 21606
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21606
caaggaaga                                                                9


<210> 21607
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21607
caaggaag                                                                 8


<210> 21608
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21608
aaggaagaug gcauuucuag                                                   20


<210> 21609
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21609
aaggaagaug gcauuucta                                                    19


<210> 21610
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21610
aaggaagaug gcauuuct                                                     18


<210> 21611
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21611
aaggaagaug gcauutc                                                      17


<210> 21612
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21612
aaggaagaug gcautt                                                       16


<210> 21613
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21613
aaggaagaug gcatt                                                        15


<210> 21614
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21614
aaggaagaug gcat                                                         14


<210> 21615
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21615
aaggaagaug gca                                                          13


<210> 21616
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21616
aaggaagaug gc                                                           12


<210> 21617
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21617
aaggaagaug g                                                            11


<210> 21618
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21618
aaggaagatg                                                              10


<210> 21619
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21619
aaggaagat                                                                9


<210> 21620
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21620
aaggaaga                                                                 8


<210> 21621
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21621
aggaagaugg cauuucuag                                                    19


<210> 21622
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21622
aggaagaugg cauuucta                                                     18


<210> 21623
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21623
aggaagaugg cauuuct                                                      17


<210> 21624
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21624
aggaagaugg cauutc                                                       16


<210> 21625
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21625
aggaagaugg cautt                                                        15


<210> 21626
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21626
aggaagaugg catt                                                         14


<210> 21627
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21627
aggaagaugg cat                                                          13


<210> 21628
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21628
aggaagaugg ca                                                           12


<210> 21629
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21629
aggaagaugg                                                              10


<210> 21630
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21630
aggaagatg                                                                9


<210> 21631
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21631
aggaagat                                                                 8


<210> 21632
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21632
ggaagauggc auuucuag                                                     18


<210> 21633
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21633
ggaagauggc auuucta                                                      17


<210> 21634
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21634
ggaagauggc auuuct                                                       16


<210> 21635
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21635
ggaagauggc auutc                                                        15


<210> 21636
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21636
ggaagauggc autt                                                         14


<210> 21637
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21637
ggaagauggc att                                                          13


<210> 21638
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21638
ggaagauggc at                                                           12


<210> 21639
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21639
ggaagauggc a                                                            11


<210> 21640
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21640
ggaagauggc                                                              10


<210> 21641
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21641
ggaagatg                                                                 8


<210> 21642
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21642
gaagauggca uuucuag                                                      17


<210> 21643
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21643
gaagauggca uuucta                                                       16


<210> 21644
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21644
gaagauggca uutc                                                         14


<210> 21645
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21645
gaagauggca utt                                                          13


<210> 21646
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21646
gaagauggca tt                                                           12


<210> 21647
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21647
gaagauggca t                                                            11


<210> 21648
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21648
gaagauggca                                                              10


<210> 21649
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21649
gaagauggc                                                                9


<210> 21650
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21650
gaagaugg                                                                 8


<210> 21651
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21651
aagauggcau uucuag                                                       16


<210> 21652
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21652
aagauggcau uucta                                                        15


<210> 21653
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21653
aagauggcau uuct                                                         14


<210> 21654
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21654
aagauggcau utc                                                          13


<210> 21655
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21655
aagauggcau tt                                                           12


<210> 21656
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21656
aagauggcat t                                                            11


<210> 21657
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21657
aagauggcat                                                              10


<210> 21658
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21658
aagauggca                                                                9


<210> 21659
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21659
aagauggc                                                                 8


<210> 21660
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21660
agauggcauu ucuag                                                        15


<210> 21661
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21661
agauggcauu ucta                                                         14


<210> 21662
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21662
agauggcauu uct                                                          13


<210> 21663
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21663
agauggcauu tc                                                           12


<210> 21664
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21664
agauggcaut t                                                            11


<210> 21665
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21665
agauggcatt                                                              10


<210> 21666
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21666
agauggcat                                                                9


<210> 21667
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21667
agauggca                                                                 8


<210> 21668
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21668
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 21669
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21669
ctccaacauc aaggaagaug gcauuucta                                         29


<210> 21670
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21670
ctccaacauc aaggaagaug gcauuuct                                          28


<210> 21671
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21671
ctccaacauc aaggaagaug gcauutc                                           27


<210> 21672
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21672
ctccaacauc aaggaagaug gcautt                                            26


<210> 21673
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21673
ctccaacauc aaggaagaug gcatt                                             25


<210> 21674
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21674
ctccaacauc aaggaagaug gcat                                              24


<210> 21675
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21675
ctccaacauc aaggaagaug gca                                               23


<210> 21676
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21676
ctccaacauc aaggaagaug gc                                                22


<210> 21677
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21677
ctccaacauc aaggaagaug g                                                 21


<210> 21678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21678
ctccaacauc aaggaagatg                                                   20


<210> 21679
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21679
ctccaacauc aaggaagat                                                    19


<210> 21680
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21680
ctccaacauc aaggaaga                                                     18


<210> 21681
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21681
ctccaacauc aaggaag                                                      17


<210> 21682
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21682
tccaacauca aggaagaugg cauuucuag                                         29


<210> 21683
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21683
tccaacauca aggaagaugg cauuucta                                          28


<210> 21684
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21684
tccaacauca aggaagaugg cauuuct                                           27


<210> 21685
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21685
tccaacauca aggaagaugg cauutc                                            26


<210> 21686
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21686
tccaacauca aggaagaugg cautt                                             25


<210> 21687
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21687
tccaacauca aggaagaugg catt                                              24


<210> 21688
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21688
tccaacauca aggaagaugg cat                                               23


<210> 21689
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21689
tccaacauca aggaagaugg ca                                                22


<210> 21690
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21690
tccaacauca aggaagaugg c                                                 21


<210> 21691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21691
tccaacauca aggaagaugg                                                   20


<210> 21692
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21692
tccaacauca aggaagatg                                                    19


<210> 21693
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21693
tccaacauca aggaagat                                                     18


<210> 21694
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21694
tccaacauca aggaaga                                                      17


<210> 21695
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21695
tccaacauca aggaag                                                       16


<210> 21696
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21696
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 21697
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21697
ccaacaucaa ggaagauggc auuucta                                           27


<210> 21698
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21698
ccaacaucaa ggaagauggc auuuct                                            26


<210> 21699
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21699
ccaacaucaa ggaagauggc auutc                                             25


<210> 21700
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21700
ccaacaucaa ggaagauggc autt                                              24


<210> 21701
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21701
ccaacaucaa ggaagauggc att                                               23


<210> 21702
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21702
ccaacaucaa ggaagauggc at                                                22


<210> 21703
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21703
ccaacaucaa ggaagauggc a                                                 21


<210> 21704
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21704
ccaacaucaa ggaagauggc                                                   20


<210> 21705
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21705
ccaacaucaa ggaagaugg                                                    19


<210> 21706
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21706
ccaacaucaa ggaagatg                                                     18


<210> 21707
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21707
ccaacaucaa ggaagat                                                      17


<210> 21708
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21708
ccaacaucaa ggaaga                                                       16


<210> 21709
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21709
ccaacaucaa ggaag                                                        15


<210> 21710
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21710
caacaucaag gaagauggca uuucuag                                           27


<210> 21711
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21711
caacaucaag gaagauggca uuucta                                            26


<210> 21712
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21712
caacaucaag gaagauggca uuuct                                             25


<210> 21713
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21713
caacaucaag gaagauggca uutc                                              24


<210> 21714
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21714
caacaucaag gaagauggca utt                                               23


<210> 21715
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21715
caacaucaag gaagauggca tt                                                22


<210> 21716
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21716
caacaucaag gaagauggca t                                                 21


<210> 21717
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21717
caacaucaag gaagauggca                                                   20


<210> 21718
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21718
caacaucaag gaagauggc                                                    19


<210> 21719
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21719
caacaucaag gaagaugg                                                     18


<210> 21720
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21720
caacaucaag gaagatg                                                      17


<210> 21721
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21721
caacaucaag gaagat                                                       16


<210> 21722
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21722
caacaucaag gaaga                                                        15


<210> 21723
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21723
caacaucaag gaag                                                         14


<210> 21724
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21724
aacaucaagg aagauggcau uucuag                                            26


<210> 21725
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21725
aacaucaagg aagauggcau uucta                                             25


<210> 21726
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21726
aacaucaagg aagauggcau uuct                                              24


<210> 21727
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21727
aacaucaagg aagauggcau utc                                               23


<210> 21728
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21728
aacaucaagg aagauggcau tt                                                22


<210> 21729
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21729
aacaucaagg aagauggcat t                                                 21


<210> 21730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21730
aacaucaagg aagauggcat                                                   20


<210> 21731
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21731
aacaucaagg aagauggca                                                    19


<210> 21732
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21732
aacaucaagg aagauggc                                                     18


<210> 21733
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21733
aacaucaagg aagaugg                                                      17


<210> 21734
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21734
aacaucaagg aagatg                                                       16


<210> 21735
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21735
aacaucaagg aagat                                                        15


<210> 21736
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21736
aacaucaagg aaga                                                         14


<210> 21737
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21737
aacaucaagg aag                                                          13


<210> 21738
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21738
acaucaagga agauggcauu ucuag                                             25


<210> 21739
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21739
acaucaagga agauggcauu ucta                                              24


<210> 21740
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21740
acaucaagga agauggcauu uct                                               23


<210> 21741
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21741
acaucaagga agauggcauu tc                                                22


<210> 21742
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21742
acaucaagga agauggcaut t                                                 21


<210> 21743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21743
acaucaagga agauggcatt                                                   20


<210> 21744
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21744
acaucaagga agauggcat                                                    19


<210> 21745
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21745
acaucaagga agauggca                                                     18


<210> 21746
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21746
acaucaagga agauggc                                                      17


<210> 21747
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21747
acaucaagga agaugg                                                       16


<210> 21748
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21748
acaucaagga agatg                                                        15


<210> 21749
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21749
acaucaagga agat                                                         14


<210> 21750
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21750
acaucaagga aga                                                          13


<210> 21751
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21751
acaucaagga ag                                                           12


<210> 21752
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21752
caucaaggaa gauggcauuu cuag                                              24


<210> 21753
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21753
caucaaggaa gauggcauuu cta                                               23


<210> 21754
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21754
caucaaggaa gauggcauuu ct                                                22


<210> 21755
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21755
caucaaggaa gauggcauut c                                                 21


<210> 21756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21756
caucaaggaa gauggcautt                                                   20


<210> 21757
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21757
caucaaggaa gauggcatt                                                    19


<210> 21758
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21758
caucaaggaa gauggcat                                                     18


<210> 21759
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21759
caucaaggaa gauggca                                                      17


<210> 21760
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21760
caucaaggaa gauggc                                                       16


<210> 21761
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21761
caucaaggaa gaugg                                                        15


<210> 21762
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21762
caucaaggaa gatg                                                         14


<210> 21763
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21763
caucaaggaa gat                                                          13


<210> 21764
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21764
caucaaggaa ga                                                           12


<210> 21765
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21765
caucaaggaa g                                                            11


<210> 21766
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21766
atcaaggaag auggcauuuc uag                                               23


<210> 21767
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21767
atcaaggaag auggcauuuc ta                                                22


<210> 21768
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21768
atcaaggaag auggcauuuc t                                                 21


<210> 21769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21769
atcaaggaag auggcauutc                                                   20


<210> 21770
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21770
atcaaggaag auggcautt                                                    19


<210> 21771
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21771
atcaaggaag auggcatt                                                     18


<210> 21772
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21772
atcaaggaag auggcat                                                      17


<210> 21773
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21773
atcaaggaag auggca                                                       16


<210> 21774
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21774
atcaaggaag auggc                                                        15


<210> 21775
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21775
atcaaggaag augg                                                         14


<210> 21776
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21776
atcaaggaag atg                                                          13


<210> 21777
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21777
atcaaggaag at                                                           12


<210> 21778
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21778
atcaaggaag a                                                            11


<210> 21779
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21779
atcaaggaag                                                              10


<210> 21780
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21780
ccagagcagg uaccuccaac atc                                               23


<210> 21781
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21781
ccagagcagg uaccucca                                                     18


<210> 21782
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21782
ccucugugau uuuauaacuu gat                                               23


<210> 21783
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21783
tcacccacca ucaccct                                                      17


<210> 21784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21784
tgauauccuc aaggucaccc                                                   20


<210> 21785
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21785
ctgcuugaug aucaucucgu tg                                                22


<210> 21786
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21786
ctgcuugaug aucauctc                                                     18


<210> 21787
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21787
gtuuccuuag uaaccacag                                                    19


<210> 21788
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21788
gtuuccuuag uaaccac                                                      17


<210> 21789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21789
tcaaggaaga uggcauuuct                                                   20


<210> 21790
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21790
tcaaggaaga uggcauuucu ag                                                22


<210> 21791
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21791
gguaaguucu guccaagc                                                     18


<210> 21792
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21792
gtaaguucug uccaagcc                                                     18


<210> 21793
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21793
agucgguaag uucugucc                                                     18


<210> 21794
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21794
ctguccaagc ccgguuga                                                     18


<210> 21795
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21795
taaguucugu ccaag                                                        15


<210> 21796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21796
ttcuguccaa gcccgguuga                                                   20


<210> 21797
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21797
ttcuguccaa gcccggutg                                                    19


<210> 21798
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21798
ttcuguccaa gcccggtt                                                     18


<210> 21799
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21799
ttcuguccaa gcccggt                                                      17


<210> 21800
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21800
ttcuguccaa gcccgg                                                       16


<210> 21801
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21801
ttcuguccaa gcccg                                                        15


<210> 21802
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21802
ttcuguccaa gccc                                                         14


<210> 21803
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21803
ttcuguccaa gcc                                                          13


<210> 21804
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21804
ttcuguccaa gc                                                           12


<210> 21805
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21805
ttcuguccaa g                                                            11


<210> 21806
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21806
ttcuguccaa                                                              10


<210> 21807
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21807
ttcugucca                                                                9


<210> 21808
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21808
ttcugucc                                                                 8


<210> 21809
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21809
tcuguccaag cccgguuga                                                    19


<210> 21810
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21810
tcuguccaag cccggutg                                                     18


<210> 21811
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21811
tcuguccaag cccggtt                                                      17


<210> 21812
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21812
tcuguccaag cccggt                                                       16


<210> 21813
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21813
tcuguccaag cccgg                                                        15


<210> 21814
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21814
tcuguccaag cccg                                                         14


<210> 21815
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21815
tcuguccaag ccc                                                          13


<210> 21816
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21816
tcuguccaag cc                                                           12


<210> 21817
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21817
tcuguccaag c                                                            11


<210> 21818
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21818
tcuguccaag                                                              10


<210> 21819
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21819
tcuguccaa                                                                9


<210> 21820
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21820
tcugucca                                                                 8


<210> 21821
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21821
ctguccaagc ccggutg                                                      17


<210> 21822
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21822
ctguccaagc ccggtt                                                       16


<210> 21823
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21823
ctguccaagc ccggt                                                        15


<210> 21824
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21824
ctguccaagc ccgg                                                         14


<210> 21825
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21825
ctguccaagc ccg                                                          13


<210> 21826
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21826
ctguccaagc cc                                                           12


<210> 21827
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21827
ctguccaagc c                                                            11


<210> 21828
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21828
ctguccaagc                                                              10


<210> 21829
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21829
ctguccaag                                                                9


<210> 21830
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21830
ctguccaa                                                                 8


<210> 21831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21831
gtucugucca agcccggutg                                                   20


<210> 21832
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21832
gtucugucca agcccggtt                                                    19


<210> 21833
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21833
gtucugucca agcccggt                                                     18


<210> 21834
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21834
gtucugucca agcccgg                                                      17


<210> 21835
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21835
gtucugucca agcccg                                                       16


<210> 21836
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21836
gtucugucca agccc                                                        15


<210> 21837
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21837
gtucugucca agcc                                                         14


<210> 21838
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21838
gtucugucca agc                                                          13


<210> 21839
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21839
gtucugucca ag                                                           12


<210> 21840
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21840
gtucugucca a                                                            11


<210> 21841
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21841
gtucugucca                                                              10


<210> 21842
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21842
gtucugucc                                                                9


<210> 21843
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21843
gtucugtc                                                                 8


<210> 21844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21844
aguucugucc aagcccggtt                                                   20


<210> 21845
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21845
aguucugucc aagcccggt                                                    19


<210> 21846
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21846
aguucugucc aagcccgg                                                     18


<210> 21847
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21847
aguucugucc aagcccg                                                      17


<210> 21848
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21848
aguucugucc aagccc                                                       16


<210> 21849
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21849
aguucugucc aagcc                                                        15


<210> 21850
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21850
aguucugucc aagc                                                         14


<210> 21851
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21851
aguucugucc aag                                                          13


<210> 21852
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21852
aguucugucc aa                                                           12


<210> 21853
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21853
aguucugucc a                                                            11


<210> 21854
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21854
aguucugucc                                                              10


<210> 21855
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21855
aguucugtc                                                                9


<210> 21856
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21856
aguucugt                                                                 8


<210> 21857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21857
aaguucuguc caagcccggt                                                   20


<210> 21858
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21858
aaguucuguc caagcccgg                                                    19


<210> 21859
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21859
aaguucuguc caagcccg                                                     18


<210> 21860
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21860
aaguucuguc caagccc                                                      17


<210> 21861
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21861
aaguucuguc caagcc                                                       16


<210> 21862
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21862
aaguucuguc caagc                                                        15


<210> 21863
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21863
aaguucuguc caag                                                         14


<210> 21864
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21864
aaguucuguc caa                                                          13


<210> 21865
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21865
aaguucuguc ca                                                           12


<210> 21866
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21866
aaguucuguc c                                                            11


<210> 21867
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21867
aaguucugtc                                                              10


<210> 21868
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21868
aaguucugt                                                                9


<210> 21869
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21869
aaguuctg                                                                 8


<210> 21870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21870
taaguucugu ccaagcccgg                                                   20


<210> 21871
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21871
taaguucugu ccaagcccg                                                    19


<210> 21872
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21872
taaguucugu ccaagccc                                                     18


<210> 21873
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21873
taaguucugu ccaagcc                                                      17


<210> 21874
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21874
taaguucugu ccaagc                                                       16


<210> 21875
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21875
taaguucugu ccaa                                                         14


<210> 21876
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21876
taaguucugu cca                                                          13


<210> 21877
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21877
taaguucugu cc                                                           12


<210> 21878
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21878
taaguucugt c                                                            11


<210> 21879
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21879
taaguucugt                                                              10


<210> 21880
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21880
taaguuctg                                                                9


<210> 21881
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21881
taaguuct                                                                 8


<210> 21882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21882
gtaaguucug uccaagcccg                                                   20


<210> 21883
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21883
gtaaguucug uccaagccc                                                    19


<210> 21884
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21884
gtaaguucug uccaagc                                                      17


<210> 21885
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21885
gtaaguucug uccaag                                                       16


<210> 21886
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21886
gtaaguucug uccaa                                                        15


<210> 21887
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21887
gtaaguucug ucca                                                         14


<210> 21888
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21888
gtaaguucug ucc                                                          13


<210> 21889
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21889
gtaaguucug tc                                                           12


<210> 21890
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21890
gtaaguucug t                                                            11


<210> 21891
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21891
gtaaguuctg                                                              10


<210> 21892
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21892
gtaaguuct                                                                9


<210> 21893
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21893
gtaagutc                                                                 8


<210> 21894
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21894
gguaaguucu guccaagccc                                                   20


<210> 21895
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21895
gguaaguucu guccaagcc                                                    19


<210> 21896
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21896
gguaaguucu guccaag                                                      17


<210> 21897
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21897
gguaaguucu guccaa                                                       16


<210> 21898
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21898
gguaaguucu gucca                                                        15


<210> 21899
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21899
gguaaguucu gucc                                                         14


<210> 21900
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21900
gguaaguucu gtc                                                          13


<210> 21901
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21901
gguaaguucu gt                                                           12


<210> 21902
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21902
gguaaguuct g                                                            11


<210> 21903
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21903
gguaaguuct                                                              10


<210> 21904
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21904
gguaagutc                                                                9


<210> 21905
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21905
gguaagtt                                                                 8


<210> 21906
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21906
cgguaaguuc uguccaagcc                                                   20


<210> 21907
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21907
cgguaaguuc uguccaagc                                                    19


<210> 21908
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21908
cgguaaguuc uguccaag                                                     18


<210> 21909
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21909
cgguaaguuc uguccaa                                                      17


<210> 21910
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21910
cgguaaguuc ugucca                                                       16


<210> 21911
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21911
cgguaaguuc ugucc                                                        15


<210> 21912
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21912
cgguaaguuc ugtc                                                         14


<210> 21913
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21913
cgguaaguuc ugt                                                          13


<210> 21914
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21914
cgguaaguuc tg                                                           12


<210> 21915
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21915
cgguaaguuc t                                                            11


<210> 21916
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21916
cgguaagutc                                                              10


<210> 21917
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21917
cgguaagtt                                                                9


<210> 21918
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21918
cgguaagt                                                                 8


<210> 21919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21919
tcgguaaguu cuguccaagc                                                   20


<210> 21920
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21920
tcgguaaguu cuguccaag                                                    19


<210> 21921
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21921
tcgguaaguu cuguccaa                                                     18


<210> 21922
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21922
tcgguaaguu cugucca                                                      17


<210> 21923
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21923
tcgguaaguu cugucc                                                       16


<210> 21924
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21924
tcgguaaguu cugtc                                                        15


<210> 21925
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21925
tcgguaaguu cugt                                                         14


<210> 21926
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21926
tcgguaaguu ctg                                                          13


<210> 21927
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21927
tcgguaaguu ct                                                           12


<210> 21928
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21928
tcgguaagut c                                                            11


<210> 21929
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21929
tcgguaagtt                                                              10


<210> 21930
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21930
tcgguaagt                                                                9


<210> 21931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21931
gtcgguaagu ucuguccaag                                                   20


<210> 21932
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21932
gtcgguaagu ucuguccaa                                                    19


<210> 21933
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21933
gtcgguaagu ucugucca                                                     18


<210> 21934
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21934
gtcgguaagu ucugucc                                                      17


<210> 21935
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21935
gtcgguaagu ucugtc                                                       16


<210> 21936
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21936
gtcgguaagu ucugt                                                        15


<210> 21937
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21937
gtcgguaagu uctg                                                         14


<210> 21938
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21938
gtcgguaagu uct                                                          13


<210> 21939
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21939
gtcgguaagu tc                                                           12


<210> 21940
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21940
gtcgguaagt t                                                            11


<210> 21941
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21941
gtcgguaagt                                                              10


<210> 21942
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21942
agucgguaag uucuguccaa                                                   20


<210> 21943
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21943
agucgguaag uucugucca                                                    19


<210> 21944
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21944
agucgguaag uucugtc                                                      17


<210> 21945
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21945
agucgguaag uucugt                                                       16


<210> 21946
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21946
agucgguaag uuctg                                                        15


<210> 21947
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21947
agucgguaag uuct                                                         14


<210> 21948
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21948
agucgguaag utc                                                          13


<210> 21949
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21949
agucgguaag tt                                                           12


<210> 21950
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21950
agucgguaag t                                                            11


<210> 21951
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21951
cagucgguaa guucugucca                                                   20


<210> 21952
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21952
cagucgguaa guucugucc                                                    19


<210> 21953
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21953
cagucgguaa guucugtc                                                     18


<210> 21954
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21954
cagucgguaa guucugt                                                      17


<210> 21955
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21955
cagucgguaa guuctg                                                       16


<210> 21956
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21956
cagucgguaa guuct                                                        15


<210> 21957
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21957
cagucgguaa gutc                                                         14


<210> 21958
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21958
cagucgguaa gtt                                                          13


<210> 21959
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21959
cagucgguaa gt                                                           12


<210> 21960
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21960
ccagucggua aguucugucc                                                   20


<210> 21961
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21961
ccagucggua aguucugtc                                                    19


<210> 21962
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21962
ccagucggua aguucugt                                                     18


<210> 21963
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21963
ccagucggua aguuctg                                                      17


<210> 21964
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21964
ccagucggua aguuct                                                       16


<210> 21965
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21965
ccagucggua agutc                                                        15


<210> 21966
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21966
ccagucggua agtt                                                         14


<210> 21967
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21967
ccagucggua agt                                                          13


<210> 21968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21968
gccagucggu aaguucugtc                                                   20


<210> 21969
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21969
gccagucggu aaguucugt                                                    19


<210> 21970
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21970
gccagucggu aaguuctg                                                     18


<210> 21971
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21971
gccagucggu aaguuct                                                      17


<210> 21972
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21972
gccagucggu aagutc                                                       16


<210> 21973
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21973
gccagucggu aagtt                                                        15


<210> 21974
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21974
gccagucggu aagt                                                         14


<210> 21975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21975
tcaaggaaga uggcauuuct                                                   20


<210> 21976
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21976
tcaaggaaga uggcauuucu ag                                                22


<210> 21977
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21977
tcaaggaaga uggcat                                                       16


<210> 21978
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21978
gaagauggca uuuct                                                        15


<210> 21979
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21979
tcaaggaaga uggcauuuct a                                                 21


<210> 21980
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21980
tcaaggaaga uggcauutc                                                    19


<210> 21981
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21981
tcaaggaaga uggcautt                                                     18


<210> 21982
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21982
tcaaggaaga uggcatt                                                      17


<210> 21983
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21983
tcaaggaaga uggca                                                        15


<210> 21984
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21984
tcaaggaaga uggc                                                         14


<210> 21985
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21985
tcaaggaaga ugg                                                          13


<210> 21986
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21986
tcaaggaaga tg                                                           12


<210> 21987
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21987
tcaaggaaga t                                                            11


<210> 21988
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21988
tcaaggaaga                                                              10


<210> 21989
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21989
tcaaggaag                                                                9


<210> 21990
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21990
caaggaagau ggcauuucua g                                                 21


<210> 21991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21991
caaggaagau ggcauuucta                                                   20


<210> 21992
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21992
caaggaagau ggcauuuct                                                    19


<210> 21993
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21993
caaggaagau ggcauutc                                                     18


<210> 21994
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21994
caaggaagau ggcautt                                                      17


<210> 21995
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21995
caaggaagau ggcatt                                                       16


<210> 21996
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21996
caaggaagau ggcat                                                        15


<210> 21997
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21997
caaggaagau ggca                                                         14


<210> 21998
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21998
caaggaagau ggc                                                          13


<210> 21999
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 21999
caaggaagau gg                                                           12


<210> 22000
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22000
caaggaagat g                                                            11


<210> 22001
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22001
caaggaagat                                                              10


<210> 22002
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22002
caaggaaga                                                                9


<210> 22003
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22003
caaggaag                                                                 8


<210> 22004
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22004
aaggaagaug gcauuucuag                                                   20


<210> 22005
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22005
aaggaagaug gcauuucta                                                    19


<210> 22006
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22006
aaggaagaug gcauuuct                                                     18


<210> 22007
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22007
aaggaagaug gcauutc                                                      17


<210> 22008
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22008
aaggaagaug gcautt                                                       16


<210> 22009
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22009
aaggaagaug gcatt                                                        15


<210> 22010
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22010
aaggaagaug gcat                                                         14


<210> 22011
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22011
aaggaagaug gca                                                          13


<210> 22012
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22012
aaggaagaug gc                                                           12


<210> 22013
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22013
aaggaagaug g                                                            11


<210> 22014
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22014
aaggaagatg                                                              10


<210> 22015
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22015
aaggaagat                                                                9


<210> 22016
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA/Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22016
aaggaaga                                                                 8


<210> 22017
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22017
aggaagaugg cauuucuag                                                    19


<210> 22018
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22018
aggaagaugg cauuucta                                                     18


<210> 22019
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22019
aggaagaugg cauuuct                                                      17


<210> 22020
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22020
aggaagaugg cauutc                                                       16


<210> 22021
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22021
aggaagaugg cautt                                                        15


<210> 22022
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22022
aggaagaugg catt                                                         14


<210> 22023
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22023
aggaagaugg cat                                                          13


<210> 22024
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22024
aggaagaugg ca                                                           12


<210> 22025
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22025
aggaagaugg                                                              10


<210> 22026
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22026
aggaagatg                                                                9


<210> 22027
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22027
aggaagat                                                                 8


<210> 22028
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22028
ggaagauggc auuucuag                                                     18


<210> 22029
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22029
ggaagauggc auuucta                                                      17


<210> 22030
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22030
ggaagauggc auuuct                                                       16


<210> 22031
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22031
ggaagauggc auutc                                                        15


<210> 22032
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22032
ggaagauggc autt                                                         14


<210> 22033
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22033
ggaagauggc att                                                          13


<210> 22034
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22034
ggaagauggc at                                                           12


<210> 22035
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22035
ggaagauggc a                                                            11


<210> 22036
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22036
ggaagauggc                                                              10


<210> 22037
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22037
ggaagatg                                                                 8


<210> 22038
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22038
gaagauggca uuucuag                                                      17


<210> 22039
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22039
gaagauggca uuucta                                                       16


<210> 22040
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22040
gaagauggca uutc                                                         14


<210> 22041
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22041
gaagauggca utt                                                          13


<210> 22042
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22042
gaagauggca tt                                                           12


<210> 22043
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22043
gaagauggca t                                                            11


<210> 22044
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22044
gaagauggca                                                              10


<210> 22045
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22045
gaagauggc                                                                9


<210> 22046
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22046
gaagaugg                                                                 8


<210> 22047
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22047
aagauggcau uucuag                                                       16


<210> 22048
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22048
aagauggcau uucta                                                        15


<210> 22049
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22049
aagauggcau uuct                                                         14


<210> 22050
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22050
aagauggcau utc                                                          13


<210> 22051
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22051
aagauggcau tt                                                           12


<210> 22052
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22052
aagauggcat t                                                            11


<210> 22053
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22053
aagauggcat                                                              10


<210> 22054
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22054
aagauggca                                                                9


<210> 22055
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22055
aagauggc                                                                 8


<210> 22056
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22056
agauggcauu ucuag                                                        15


<210> 22057
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22057
agauggcauu ucta                                                         14


<210> 22058
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22058
agauggcauu uct                                                          13


<210> 22059
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22059
agauggcauu tc                                                           12


<210> 22060
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22060
agauggcaut t                                                            11


<210> 22061
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22061
agauggcatt                                                              10


<210> 22062
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22062
agauggcat                                                                9


<210> 22063
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (8)..(8)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22063
agauggca                                                                 8


<210> 22064
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (30)..(30)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22064
ctccaacauc aaggaagaug gcauuucuag                                        30


<210> 22065
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22065
ctccaacauc aaggaagaug gcauuucta                                         29


<210> 22066
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22066
ctccaacauc aaggaagaug gcauuuct                                          28


<210> 22067
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22067
ctccaacauc aaggaagaug gcauutc                                           27


<210> 22068
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22068
ctccaacauc aaggaagaug gcautt                                            26


<210> 22069
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22069
ctccaacauc aaggaagaug gcatt                                             25


<210> 22070
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22070
ctccaacauc aaggaagaug gcat                                              24


<210> 22071
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22071
ctccaacauc aaggaagaug gca                                               23


<210> 22072
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22072
ctccaacauc aaggaagaug gc                                                22


<210> 22073
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22073
ctccaacauc aaggaagaug g                                                 21


<210> 22074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22074
ctccaacauc aaggaagatg                                                   20


<210> 22075
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22075
ctccaacauc aaggaagat                                                    19


<210> 22076
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22076
ctccaacauc aaggaaga                                                     18


<210> 22077
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22077
ctccaacauc aaggaag                                                      17


<210> 22078
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (29)..(29)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22078
tccaacauca aggaagaugg cauuucuag                                         29


<210> 22079
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22079
tccaacauca aggaagaugg cauuucta                                          28


<210> 22080
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22080
tccaacauca aggaagaugg cauuuct                                           27


<210> 22081
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22081
tccaacauca aggaagaugg cauutc                                            26


<210> 22082
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22082
tccaacauca aggaagaugg cautt                                             25


<210> 22083
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22083
tccaacauca aggaagaugg catt                                              24


<210> 22084
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22084
tccaacauca aggaagaugg cat                                               23


<210> 22085
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22085
tccaacauca aggaagaugg ca                                                22


<210> 22086
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22086
tccaacauca aggaagaugg c                                                 21


<210> 22087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22087
tccaacauca aggaagaugg                                                   20


<210> 22088
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22088
tccaacauca aggaagatg                                                    19


<210> 22089
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22089
tccaacauca aggaagat                                                     18


<210> 22090
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22090
tccaacauca aggaaga                                                      17


<210> 22091
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22091
tccaacauca aggaag                                                       16


<210> 22092
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (28)..(28)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22092
ccaacaucaa ggaagauggc auuucuag                                          28


<210> 22093
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22093
ccaacaucaa ggaagauggc auuucta                                           27


<210> 22094
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22094
ccaacaucaa ggaagauggc auuuct                                            26


<210> 22095
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22095
ccaacaucaa ggaagauggc auutc                                             25


<210> 22096
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22096
ccaacaucaa ggaagauggc autt                                              24


<210> 22097
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22097
ccaacaucaa ggaagauggc att                                               23


<210> 22098
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22098
ccaacaucaa ggaagauggc at                                                22


<210> 22099
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22099
ccaacaucaa ggaagauggc a                                                 21


<210> 22100
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22100
ccaacaucaa ggaagauggc                                                   20


<210> 22101
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22101
ccaacaucaa ggaagaugg                                                    19


<210> 22102
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22102
ccaacaucaa ggaagatg                                                     18


<210> 22103
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22103
ccaacaucaa ggaagat                                                      17


<210> 22104
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22104
ccaacaucaa ggaaga                                                       16


<210> 22105
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22105
ccaacaucaa ggaag                                                        15


<210> 22106
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (27)..(27)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22106
caacaucaag gaagauggca uuucuag                                           27


<210> 22107
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22107
caacaucaag gaagauggca uuucta                                            26


<210> 22108
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22108
caacaucaag gaagauggca uuuct                                             25


<210> 22109
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22109
caacaucaag gaagauggca uutc                                              24


<210> 22110
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22110
caacaucaag gaagauggca utt                                               23


<210> 22111
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22111
caacaucaag gaagauggca tt                                                22


<210> 22112
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22112
caacaucaag gaagauggca t                                                 21


<210> 22113
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22113
caacaucaag gaagauggca                                                   20


<210> 22114
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22114
caacaucaag gaagauggc                                                    19


<210> 22115
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22115
caacaucaag gaagaugg                                                     18


<210> 22116
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22116
caacaucaag gaagatg                                                      17


<210> 22117
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22117
caacaucaag gaagat                                                       16


<210> 22118
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22118
caacaucaag gaaga                                                        15


<210> 22119
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22119
caacaucaag gaag                                                         14


<210> 22120
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (26)..(26)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22120
aacaucaagg aagauggcau uucuag                                            26


<210> 22121
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22121
aacaucaagg aagauggcau uucta                                             25


<210> 22122
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22122
aacaucaagg aagauggcau uuct                                              24


<210> 22123
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22123
aacaucaagg aagauggcau utc                                               23


<210> 22124
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22124
aacaucaagg aagauggcau tt                                                22


<210> 22125
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22125
aacaucaagg aagauggcat t                                                 21


<210> 22126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22126
aacaucaagg aagauggcat                                                   20


<210> 22127
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22127
aacaucaagg aagauggca                                                    19


<210> 22128
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22128
aacaucaagg aagauggc                                                     18


<210> 22129
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22129
aacaucaagg aagaugg                                                      17


<210> 22130
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22130
aacaucaagg aagatg                                                       16


<210> 22131
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22131
aacaucaagg aagat                                                        15


<210> 22132
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22132
aacaucaagg aaga                                                         14


<210> 22133
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22133
aacaucaagg aag                                                          13


<210> 22134
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (25)..(25)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22134
acaucaagga agauggcauu ucuag                                             25


<210> 22135
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22135
acaucaagga agauggcauu ucta                                              24


<210> 22136
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22136
acaucaagga agauggcauu uct                                               23


<210> 22137
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22137
acaucaagga agauggcauu tc                                                22


<210> 22138
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22138
acaucaagga agauggcaut t                                                 21


<210> 22139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22139
acaucaagga agauggcatt                                                   20


<210> 22140
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22140
acaucaagga agauggcat                                                    19


<210> 22141
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22141
acaucaagga agauggca                                                     18


<210> 22142
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22142
acaucaagga agauggc                                                      17


<210> 22143
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22143
acaucaagga agaugg                                                       16


<210> 22144
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22144
acaucaagga agatg                                                        15


<210> 22145
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22145
acaucaagga agat                                                         14


<210> 22146
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22146
acaucaagga aga                                                          13


<210> 22147
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22147
acaucaagga ag                                                           12


<210> 22148
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (24)..(24)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22148
caucaaggaa gauggcauuu cuag                                              24


<210> 22149
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22149
caucaaggaa gauggcauuu cta                                               23


<210> 22150
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22150
caucaaggaa gauggcauuu ct                                                22


<210> 22151
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (21)..(21)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22151
caucaaggaa gauggcauut c                                                 21


<210> 22152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22152
caucaaggaa gauggcautt                                                   20


<210> 22153
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22153
caucaaggaa gauggcatt                                                    19


<210> 22154
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22154
caucaaggaa gauggcat                                                     18


<210> 22155
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22155
caucaaggaa gauggca                                                      17


<210> 22156
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22156
caucaaggaa gauggc                                                       16


<210> 22157
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22157
caucaaggaa gaugg                                                        15


<210> 22158
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22158
caucaaggaa gatg                                                         14


<210> 22159
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22159
caucaaggaa gat                                                          13


<210> 22160
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22160
caucaaggaa ga                                                           12


<210> 22161
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22161
caucaaggaa g                                                            11


<210> 22162
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22162
atcaaggaag auggcauuuc uag                                               23


<210> 22163
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22163
atcaaggaag auggcauuuc ta                                                22


<210> 22164
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22164
atcaaggaag auggcauuuc t                                                 21


<210> 22165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22165
atcaaggaag auggcauutc                                                   20


<210> 22166
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22166
atcaaggaag auggcautt                                                    19


<210> 22167
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22167
atcaaggaag auggcatt                                                     18


<210> 22168
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22168
atcaaggaag auggcat                                                      17


<210> 22169
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22169
atcaaggaag auggca                                                       16


<210> 22170
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22170
atcaaggaag auggc                                                        15


<210> 22171
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22171
atcaaggaag augg                                                         14


<210> 22172
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22172
atcaaggaag atg                                                          13


<210> 22173
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (12)..(12)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22173
atcaaggaag at                                                           12


<210> 22174
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22174
atcaaggaag a                                                            11


<210> 22175
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22175
atcaaggaag                                                              10


<210> 22176
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22176
ccagagcagg uaccuccaac atc                                               23


<210> 22177
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22177
ccagagcagg uaccucca                                                     18


<210> 22178
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (23)..(23)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22178
ccucugugau uuuauaacuu gat                                               23


<210> 22179
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22179
tcacccacca ucaccct                                                      17


<210> 22180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (20)..(20)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22180
tgauauccuc aaggucaccc                                                   20


<210> 22181
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22181
ctgcuugaug aucaucucgu tg                                                22


<210> 22182
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (4)..(4)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22182
ctgcuugaug aucauctc                                                     18


<210> 22183
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22183
gtuuccuuag uaaccacag                                                    19


<210> 22184
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22184
gtuuccuuag uaaccac                                                      17


<210> 22185
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22185
gguaaguucu guccaagc                                                     18


<210> 22186
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22186
gguaaguucu guccaagc                                                     18


<210> 22187
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22187
gguaaguuct guccaagc                                                     18


<210> 22188
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22188
gguaaguucu guccaagc                                                     18


<210> 22189
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22189
gguaaguucu guccaagc                                                     18


<210> 22190
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22190
gguaaguucu guccaagc                                                     18


<210> 22191
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22191
gguaaguucu guccaagc                                                     18


<210> 22192
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22192
gguaaguucu guccaagc                                                     18


<210> 22193
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22193
gguaaguucu guccaagc                                                     18


<210> 22194
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22194
gguaaguucu guccaagc                                                     18


<210> 22195
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22195
gguaaguucu guccaagc                                                     18


<210> 22196
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22196
gguaaguucu guccaagc                                                     18


<210> 22197
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22197
gguaaguucu guccaagc                                                     18


<210> 22198
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22198
gguaaguucu guccaagc                                                     18


<210> 22199
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22199
gguaaguuct guccaagc                                                     18


<210> 22200
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22200
gguaaguucu guccaagc                                                     18


<210> 22201
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22201
gguaaguucu guccaagc                                                     18


<210> 22202
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22202
gguaaguucu guccaagc                                                     18


<210> 22203
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22203
gguaaguucu guccaagc                                                     18


<210> 22204
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22204
gguaaguucu guccaagc                                                     18


<210> 22205
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22205
gguaaguucu guccaagc                                                     18


<210> 22206
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22206
gguaaguucu guccaagc                                                     18


<210> 22207
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22207
gguaaguucu guccaagc                                                     18


<210> 22208
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<400> 22208
gguaaguucu guccaagc                                                     18


<210> 22209
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22209
gguaaguucu guccaagc                                                     18


<210> 22210
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22210
gguaaguucu guccaagc                                                     18


<210> 22211
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22211
gguaaguuct guccaagc                                                     18


<210> 22212
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22212
gguaaguucu guccaagc                                                     18


<210> 22213
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22213
gguaaguucu guccaagc                                                     18


<210> 22214
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22214
gguaaguucu guccaagc                                                     18


<210> 22215
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22215
gguaaguucu guccaagc                                                     18


<210> 22216
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22216
gguaaguucu guccaagc                                                     18


<210> 22217
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22217
gguaaguucu guccaagc                                                     18


<210> 22218
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22218
gguaaguucu guccaagc                                                     18


<210> 22219
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22219
gguaaguucu guccaagc                                                     18


<210> 22220
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22220
gguaaguucu guccaagc                                                     18


<210> 22221
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22221
gguaaguucu guccaagc                                                     18


<210> 22222
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22222
gguaaguucu guccaagc                                                     18


<210> 22223
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22223
gguaaguuct guccaagc                                                     18


<210> 22224
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22224
gguaaguucu guccaagc                                                     18


<210> 22225
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22225
gguaaguucu guccaagc                                                     18


<210> 22226
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22226
gguaaguucu guccaagc                                                     18


<210> 22227
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22227
gguaaguucu guccaagc                                                     18


<210> 22228
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22228
gguaaguucu guccaagc                                                     18


<210> 22229
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22229
gguaaguucu guccaagc                                                     18


<210> 22230
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22230
gguaaguucu guccaagc                                                     18


<210> 22231
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22231
gguaaguucu guccaagc                                                     18


<210> 22232
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22232
gguaaguucu guccaagc                                                     18


<210> 22233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 22233
tcaaggaaga uggcauuucu                                                   20


<210> 22234
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<400> 22234
ucaaggaaga uggcauuucu                                                   20


<210> 22235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22235
tcaaggaaga uggcauuuct                                                   20


<210> 22236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 22236
tcaaggaaga uggcauuucu                                                   20


<210> 22237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 22237
tcaaggaaga uggcauuucu                                                   20


<210> 22238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22238
tcaaggaaga uggcauuuct                                                   20


<210> 22239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22239
tcaaggaaga uggcauuuct                                                   20


<210> 22240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22240
tcaaggaaga uggcauuuct                                                   20


<210> 22241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22241
tcaaggaaga uggcauuuct                                                   20


<210> 22242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22242
tcaaggaaga tggcauuuct                                                   20


<210> 22243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22243
tcaaggaaga uggcauuuct                                                   20


<210> 22244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22244
tcaaggaaga uggcauuuct                                                   20


<210> 22245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22245
tcaaggaaga uggcauuuct                                                   20


<210> 22246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22246
tcaaggaaga uggcauuuct                                                   20


<210> 22247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22247
tcaaggaaga uggcauuuct                                                   20


<210> 22248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 22248
tcaaggaaga uggcauuucu                                                   20


<210> 22249
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<400> 22249
ucaaggaaga uggcauuucu                                                   20


<210> 22250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22250
tcaaggaaga uggcauuuct                                                   20


<210> 22251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 22251
tcaaggaaga uggcauuucu                                                   20


<210> 22252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<400> 22252
tcaaggaaga uggcauuucu                                                   20


<210> 22253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22253
tcaaggaaga uggcauuuct                                                   20


<210> 22254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22254
tcaaggaaga uggcauuuct                                                   20


<210> 22255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22255
tcaaggaaga uggcauuuct                                                   20


<210> 22256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22256
tcaaggaaga uggcauuuct                                                   20


<210> 22257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22257
tcaaggaaga tggcauuuct                                                   20


<210> 22258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22258
tcaaggaaga uggcauuuct                                                   20


<210> 22259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22259
tcaaggaaga uggcauuuct                                                   20


<210> 22260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22260
tcaaggaaga uggcauuuct                                                   20


<210> 22261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22261
tcaaggaaga uggcauuuct                                                   20


<210> 22262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22262
tcaaggaaga uggcauuuct                                                   20


<210> 22263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22263
tcaaggaaga uggcauuucu                                                   20


<210> 22264
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22264
ucaaggaaga uggcauuucu                                                   20


<210> 22265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22265
tcaaggaaga uggcauuuct                                                   20


<210> 22266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22266
tcaaggaaga uggcauuucu                                                   20


<210> 22267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22267
tcaaggaaga uggcauuucu                                                   20


<210> 22268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22268
tcaaggaaga uggcauuuct                                                   20


<210> 22269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22269
tcaaggaaga uggcauuuct                                                   20


<210> 22270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22270
tcaaggaaga uggcauuuct                                                   20


<210> 22271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22271
tcaaggaaga uggcauuuct                                                   20


<210> 22272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22272
tcaaggaaga tggcauuuct                                                   20


<210> 22273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22273
tcaaggaaga uggcauuuct                                                   20


<210> 22274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22274
tcaaggaaga uggcauuuct                                                   20


<210> 22275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22275
tcaaggaaga uggcauuuct                                                   20


<210> 22276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22276
tcaaggaaga uggcauuuct                                                   20


<210> 22277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22277
tcaaggaaga uggcauuuct                                                   20


<210> 22278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22278
tcaaggaaga uggcauuucu                                                   20


<210> 22279
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22279
ucaaggaaga uggcauuucu                                                   20


<210> 22280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22280
tcaaggaaga uggcauuuct                                                   20


<210> 22281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22281
tcaaggaaga uggcauuucu                                                   20


<210> 22282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22282
tcaaggaaga uggcauuucu                                                   20


<210> 22283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22283
tcaaggaaga uggcauuuct                                                   20


<210> 22284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22284
tcaaggaaga uggcauuuct                                                   20


<210> 22285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22285
tcaaggaaga uggcauuuct                                                   20


<210> 22286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22286
tcaaggaaga uggcauuuct                                                   20


<210> 22287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22287
tcaaggaaga tggcauuuct                                                   20


<210> 22288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22288
tcaaggaaga uggcauuuct                                                   20


<210> 22289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22289
tcaaggaaga uggcauuuct                                                   20


<210> 22290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22290
tcaaggaaga uggcauuuct                                                   20


<210> 22291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22291
tcaaggaaga uggcauuuct                                                   20


<210> 22292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22292
tcaaggaaga uggcauuuct                                                   20


<210> 22293
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 22293
tcaaggaaga uggcauuucu ag                                                22


<210> 22294
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 22294
tcaaggaaga uggcauuucu ag                                                22


<210> 22295
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22295
tcaaggaaga uggcauuucu ag                                                22


<210> 22296
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22296
tcaaggaaga uggcauuucu ag                                                22


<210> 22297
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22297
tcaaggaaga uggcauuucu ag                                                22


<210> 22298
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22298
tcaaggaaga uggcauuucu ag                                                22


<210> 22299
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22299
tcaaggaaga uggcauuucu ag                                                22


<210> 22300
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22300
tcaaggaaga uggcauuucu ag                                                22


<210> 22301
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22301
tcaaggaaga uggcauuucu ag                                                22


<210> 22302
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22302
tcaaggaaga uggcauuucu ag                                                22


<210> 22303
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<400> 22303
tcaaggaaga uggcauuucu ag                                                22


<210> 22304
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<400> 22304
tcaaggaaga uggcauuucu ag                                                22


<210> 22305
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22305
tcaaggaaga uggcauuucu ag                                                22


<210> 22306
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22306
tcaaggaaga uggcauuucu ag                                                22


<210> 22307
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22307
tcaaggaaga uggcauuucu ag                                                22


<210> 22308
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22308
tcaaggaaga uggcauuucu ag                                                22


<210> 22309
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22309
tcaaggaaga uggcauuucu ag                                                22


<210> 22310
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22310
tcaaggaaga uggcauuucu ag                                                22


<210> 22311
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22311
tcaaggaaga uggcauuucu ag                                                22


<210> 22312
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22312
tcaaggaaga uggcauuucu ag                                                22


<210> 22313
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22313
tcaaggaaga uggcauuucu ag                                                22


<210> 22314
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22314
tcaaggaaga uggcauuucu ag                                                22


<210> 22315
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22315
tcaaggaaga uggcauuucu ag                                                22


<210> 22316
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22316
tcaaggaaga uggcauuucu ag                                                22


<210> 22317
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22317
tcaaggaaga uggcauuucu ag                                                22


<210> 22318
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22318
tcaaggaaga uggcauuucu ag                                                22


<210> 22319
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22319
tcaaggaaga uggcauuucu ag                                                22


<210> 22320
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22320
tcaaggaaga uggcauuucu ag                                                22


<210> 22321
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22321
tcaaggaaga uggcauuucu ag                                                22


<210> 22322
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22322
tcaaggaaga uggcauuucu ag                                                22


<210> 22323
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22323
tcaaggaaga uggcauuucu ag                                                22


<210> 22324
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22324
tcaaggaaga uggcauuucu ag                                                22


<210> 22325
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22325
tcaaggaaga uggcauuucu ag                                                22


<210> 22326
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22326
tcaaggaaga uggcauuucu ag                                                22


<210> 22327
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22327
tcaaggaaga uggcauuucu ag                                                22


<210> 22328
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22328
tcaaggaaga uggcauuucu ag                                                22


<210> 22329
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22329
tcaaggaaga uggcauuucu ag                                                22


<210> 22330
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22330
tcaaggaaga uggcauuucu ag                                                22


<210> 22331
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22331
tcaaggaaga uggcauuucu ag                                                22


<210> 22332
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Antisense Oligonucleotide"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22332
tcaaggaaga uggcauuucu ag                                                22


<210> 22333
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22333
gguaaguucu guccaagc                                                     18


<210> 22334
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22334
gguaaguucu guccaagc                                                     18


<210> 22335
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22335
gguaaguuct guccaagc                                                     18


<210> 22336
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22336
gguaaguucu guccaagc                                                     18


<210> 22337
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22337
gguaaguucu guccaagc                                                     18


<210> 22338
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22338
gguaaguucu guccaagc                                                     18


<210> 22339
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22339
gguaaguucu guccaagc                                                     18


<210> 22340
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22340
gguaaguucu guccaagc                                                     18


<210> 22341
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22341
gguaaguucu guccaagc                                                     18


<210> 22342
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22342
gguaaguucu guccaagc                                                     18


<210> 22343
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22343
gguaaguucu guccaagc                                                     18


<210> 22344
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22344
gguaaguucu guccaagc                                                     18


<210> 22345
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22345
gguaaguucu guccaagc                                                     18


<210> 22346
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22346
gguaaguucu guccaagc                                                     18


<210> 22347
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22347
gguaaguuct guccaagc                                                     18


<210> 22348
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22348
gguaaguucu guccaagc                                                     18


<210> 22349
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22349
gguaaguucu guccaagc                                                     18


<210> 22350
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22350
gguaaguucu guccaagc                                                     18


<210> 22351
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22351
gguaaguucu guccaagc                                                     18


<210> 22352
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22352
gguaaguucu guccaagc                                                     18


<210> 22353
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22353
gguaaguucu guccaagc                                                     18


<210> 22354
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22354
gguaaguucu guccaagc                                                     18


<210> 22355
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22355
gguaaguucu guccaagc                                                     18


<210> 22356
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22356
gguaaguucu guccaagc                                                     18


<210> 22357
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22357
gguaaguucu guccaagc                                                     18


<210> 22358
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22358
gguaaguucu guccaagc                                                     18


<210> 22359
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22359
gguaaguuct guccaagc                                                     18


<210> 22360
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22360
gguaaguucu guccaagc                                                     18


<210> 22361
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22361
gguaaguucu guccaagc                                                     18


<210> 22362
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22362
gguaaguucu guccaagc                                                     18


<210> 22363
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22363
gguaaguucu guccaagc                                                     18


<210> 22364
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22364
gguaaguucu guccaagc                                                     18


<210> 22365
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22365
gguaaguucu guccaagc                                                     18


<210> 22366
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22366
gguaaguucu guccaagc                                                     18


<210> 22367
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22367
gguaaguucu guccaagc                                                     18


<210> 22368
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22368
gguaaguucu guccaagc                                                     18


<210> 22369
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22369
gguaaguucu guccaagc                                                     18


<210> 22370
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22370
gguaaguucu guccaagc                                                     18


<210> 22371
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22371
gguaaguuct guccaagc                                                     18


<210> 22372
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22372
gguaaguucu guccaagc                                                     18


<210> 22373
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22373
gguaaguucu guccaagc                                                     18


<210> 22374
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22374
gguaaguucu guccaagc                                                     18


<210> 22375
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22375
gguaaguucu guccaagc                                                     18


<210> 22376
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22376
gguaaguucu guccaagc                                                     18


<210> 22377
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22377
gguaaguucu guccaagc                                                     18


<210> 22378
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22378
gguaaguucu guccaagc                                                     18


<210> 22379
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22379
gguaaguucu guccaagc                                                     18


<210> 22380
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22380
gguaaguucu guccaagc                                                     18


<210> 22381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22381
tcaaggaaga uggcauuucu                                                   20


<210> 22382
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22382
ucaaggaaga uggcauuucu                                                   20


<210> 22383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22383
tcaaggaaga uggcauuuct                                                   20


<210> 22384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22384
tcaaggaaga uggcauuucu                                                   20


<210> 22385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22385
tcaaggaaga uggcauuucu                                                   20


<210> 22386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22386
tcaaggaaga uggcauuuct                                                   20


<210> 22387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22387
tcaaggaaga uggcauuuct                                                   20


<210> 22388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22388
tcaaggaaga uggcauuuct                                                   20


<210> 22389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22389
tcaaggaaga uggcauuuct                                                   20


<210> 22390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22390
tcaaggaaga tggcauuuct                                                   20


<210> 22391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22391
tcaaggaaga uggcauuuct                                                   20


<210> 22392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22392
tcaaggaaga uggcauuuct                                                   20


<210> 22393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22393
tcaaggaaga uggcauuuct                                                   20


<210> 22394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22394
tcaaggaaga uggcauuuct                                                   20


<210> 22395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22395
tcaaggaaga uggcauuuct                                                   20


<210> 22396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22396
tcaaggaaga uggcauuucu                                                   20


<210> 22397
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22397
ucaaggaaga uggcauuucu                                                   20


<210> 22398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22398
tcaaggaaga uggcauuuct                                                   20


<210> 22399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22399
tcaaggaaga uggcauuucu                                                   20


<210> 22400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22400
tcaaggaaga uggcauuucu                                                   20


<210> 22401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22401
tcaaggaaga uggcauuuct                                                   20


<210> 22402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22402
tcaaggaaga uggcauuuct                                                   20


<210> 22403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22403
tcaaggaaga uggcauuuct                                                   20


<210> 22404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22404
tcaaggaaga uggcauuuct                                                   20


<210> 22405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22405
tcaaggaaga tggcauuuct                                                   20


<210> 22406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22406
tcaaggaaga uggcauuuct                                                   20


<210> 22407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22407
tcaaggaaga uggcauuuct                                                   20


<210> 22408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22408
tcaaggaaga uggcauuuct                                                   20


<210> 22409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22409
tcaaggaaga uggcauuuct                                                   20


<210> 22410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<400> 22410
tcaaggaaga uggcauuuct                                                   20


<210> 22411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22411
tcaaggaaga uggcauuucu                                                   20


<210> 22412
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22412
ucaaggaaga uggcauuucu                                                   20


<210> 22413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22413
tcaaggaaga uggcauuuct                                                   20


<210> 22414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22414
tcaaggaaga uggcauuucu                                                   20


<210> 22415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22415
tcaaggaaga uggcauuucu                                                   20


<210> 22416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22416
tcaaggaaga uggcauuuct                                                   20


<210> 22417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22417
tcaaggaaga uggcauuuct                                                   20


<210> 22418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22418
tcaaggaaga uggcauuuct                                                   20


<210> 22419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22419
tcaaggaaga uggcauuuct                                                   20


<210> 22420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22420
tcaaggaaga tggcauuuct                                                   20


<210> 22421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22421
tcaaggaaga uggcauuuct                                                   20


<210> 22422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22422
tcaaggaaga uggcauuuct                                                   20


<210> 22423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22423
tcaaggaaga uggcauuuct                                                   20


<210> 22424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22424
tcaaggaaga uggcauuuct                                                   20


<210> 22425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22425
tcaaggaaga uggcauuuct                                                   20


<210> 22426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22426
tcaaggaaga uggcauuucu                                                   20


<210> 22427
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22427
ucaaggaaga uggcauuucu                                                   20


<210> 22428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22428
tcaaggaaga uggcauuuct                                                   20


<210> 22429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22429
tcaaggaaga uggcauuucu                                                   20


<210> 22430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22430
tcaaggaaga uggcauuucu                                                   20


<210> 22431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22431
tcaaggaaga uggcauuuct                                                   20


<210> 22432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22432
tcaaggaaga uggcauuuct                                                   20


<210> 22433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22433
tcaaggaaga uggcauuuct                                                   20


<210> 22434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22434
tcaaggaaga uggcauuuct                                                   20


<210> 22435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (7)..(7)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (11)..(11)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22435
tcaaggaaga tggcauuuct                                                   20


<210> 22436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22436
tcaaggaaga uggcauuuct                                                   20


<210> 22437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22437
tcaaggaaga uggcauuuct                                                   20


<210> 22438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22438
tcaaggaaga uggcauuuct                                                   20


<210> 22439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22439
tcaaggaaga uggcauuuct                                                   20


<210> 22440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22440
tcaaggaaga uggcauuuct                                                   20


<210> 22441
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22441
tcaaggaaga uggcauuucu ag                                                22


<210> 22442
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22442
tcaaggaaga uggcauuucu ag                                                22


<210> 22443
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22443
tcaaggaaga uggcauuucu ag                                                22


<210> 22444
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22444
tcaaggaaga uggcauuucu ag                                                22


<210> 22445
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22445
tcaaggaaga uggcauuucu ag                                                22


<210> 22446
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22446
tcaaggaaga uggcauuucu ag                                                22


<210> 22447
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22447
tcaaggaaga uggcauuucu ag                                                22


<210> 22448
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22448
tcaaggaaga uggcauuucu ag                                                22


<210> 22449
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22449
tcaaggaaga uggcauuucu ag                                                22


<210> 22450
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22450
tcaaggaaga uggcauuucu ag                                                22


<210> 22451
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22451
tcaaggaaga uggcauuucu ag                                                22


<210> 22452
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<400> 22452
tcaaggaaga uggcauuucu ag                                                22


<210> 22453
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22453
tcaaggaaga uggcauuucu ag                                                22


<210> 22454
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22454
tcaaggaaga uggcauuucu ag                                                22


<210> 22455
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22455
tcaaggaaga uggcauuucu ag                                                22


<210> 22456
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22456
tcaaggaaga uggcauuucu ag                                                22


<210> 22457
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22457
tcaaggaaga uggcauuucu ag                                                22


<210> 22458
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22458
tcaaggaaga uggcauuucu ag                                                22


<210> 22459
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22459
tcaaggaaga uggcauuucu ag                                                22


<210> 22460
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<400> 22460
tcaaggaaga uggcauuucu ag                                                22


<210> 22461
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22461
tcaaggaaga uggcauuucu ag                                                22


<210> 22462
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22462
tcaaggaaga uggcauuucu ag                                                22


<210> 22463
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22463
tcaaggaaga uggcauuucu ag                                                22


<210> 22464
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22464
tcaaggaaga uggcauuucu ag                                                22


<210> 22465
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22465
tcaaggaaga uggcauuucu ag                                                22


<210> 22466
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22466
tcaaggaaga uggcauuucu ag                                                22


<210> 22467
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22467
tcaaggaaga uggcauuucu ag                                                22


<210> 22468
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22468
tcaaggaaga uggcauuucu ag                                                22


<210> 22469
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22469
tcaaggaaga uggcauuucu ag                                                22


<210> 22470
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22470
tcaaggaaga uggcauuucu ag                                                22


<210> 22471
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22471
tcaaggaaga uggcauuucu ag                                                22


<210> 22472
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22472
tcaaggaaga uggcauuucu ag                                                22


<210> 22473
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22473
tcaaggaaga uggcauuucu ag                                                22


<210> 22474
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22474
tcaaggaaga uggcauuucu ag                                                22


<210> 22475
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22475
tcaaggaaga uggcauuucu ag                                                22


<210> 22476
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (10)..(10)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22476
tcaaggaaga uggcauuucu ag                                                22


<210> 22477
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22477
tcaaggaaga uggcauuucu ag                                                22


<210> 22478
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22478
tcaaggaaga uggcauuucu ag                                                22


<210> 22479
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22479
tcaaggaaga uggcauuucu ag                                                22


<210> 22480
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNA/RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methyl bicyclic nucleic acid

<220>
<221> modified_base
<222> (5)..(5)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (13)..(13)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> bicyclic nucleic acid (BNA)

<220>
<221> source
<223> /note="3' tri-ethylene glycol (TEG)"

<400> 22480
tcaaggaaga uggcauuucu ag                                                22


<210> 22481
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="primer"

<400> 22481
tgaaaataag ctcaagcaga caaatc                                            26


<210> 22482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="primer"

<400> 22482
gacgcctctg ttccaaatcc                                                   20


<210> 22483
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="primer"

<400> 22483
cagtggataa aggcaaca                                                     18


<210> 22484
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="primer"

<400> 22484
gtgatggtgg gtgaccttga g                                                 21


<210> 22485
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="primer"

<400> 22485
caagcagaag gcaacaa                                                      17


<210> 22486
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(3)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22486
gguaaguucu guccaagc                                                     18


<210> 22487
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(8)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22487
gguaaguucu guccaagc                                                     18


<210> 22488
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 22488
gguaaguucu guccaag                                                      17


<210> 22489
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl modified nucleotide

<400> 22489
gguaaguucu guccaa                                                       16


<210> 22490
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RNA"


<220>
<221> source
<223> /note="5' tri-ethylene glycol (TEG)"

<220>
<221> modified_base
<222> (1)..(1)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (2)..(2)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-methoxyethyl modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> bicyclic nucleic acid (BNA)

<220>
<221> modified_base
<222> (7)..(8)
<223> 2'-O-methoxyethyl modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 5-methyl 2'-O-methoxyethyl modified nucleotide

<220>
<221> modified_base
<222> (10)..(12)
<223> 2'-O-methoxyethyl modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 5-methyl 2'-O-methoxyethyl modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methyl 2'-O-methoxyethyl modified nucleotide

<220>
<221> modified_base
<222> (15)..(17)
<223> 2'-O-methoxyethyl modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 5-methyl bicyclic nucleic acid

<400> 22490
gguaaguucu guccaagc                                                     18


